WNK1

Summary Top Help

Gene Description:

WNK lysine deficient protein kinase 1

Synonyms:

KDP, HSN2, HSAN2, PRKWNK1, p65, EG406236, Hsn2, Wnk1, WNK1, mKIAA0344, 6430573H23Rik, Prkwnk1, PSK

Orthologs:

Human WNK1 (protein-coding), Mouse Wnk1 (protein-coding), Rat Wnk1 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1 Rat: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd19	Mouse	chr6:117439553..128469043	11.03	187	2 no lod score

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm14	Rat	chr4:63276741..160891592	97.61	815

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr12:861759..1020618 (158.86 kb) View in Genome Browser

(Mouse) NCBIM37 - chr6:119873987..119988690 (114.70 kb) View in Genome Browser

(Rat) RGSC3.4 - chr4:156297841..156421820 (123.98 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for WNK1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for WNK1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 13

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 136

Hereditary sensory and autonomic neuropathy II due to novel mutation in the HSN2 gene in Mexican families.
Pacheco-Cuellar G, González-Huerta LM, Valdés-Miranda JM, Peláez-González H, Zenteno-Bacheron S, Cazarin-Barrientos J, Cuevas-Covarrubias SA
J Neurol. 2011
PubMed ID: 21625937
WNK1 regulates vasoconstriction and blood pressure response to α 1-adrenergic stimulation in mice.
Bergaya S, Faure S, Baudrie V, Rio M, Escoubet B, Bonnin P, Henrion D, Loirand G, Achard JM, Jeunemaitre X, Hadchouel J
Hypertension. 2011
PubMed ID: 21768522
WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters.
Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP
J Biol Chem. 2011
PubMed ID: 21733846
Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans.
Putku M, Kepp K, Org E, Sõber S, Comas D, Viigimaa M, Veldre G, Juhanson P, Hallast P, Tõnisson N, HYPertension in ESTonia (HYPEST), Shaw-Hawkins S, Caulfield MJ, BRItish Genetics of HyperTension (BRIGHT), Khusnutdinova E, Kožich V, Munroe PB, Laan M
Hum Mutat. 2011
PubMed ID: 21520334
Association of WNK1 exon 1 polymorphisms with essential hypertension in Hani and Yi minorities of China.
Cun Y, Li J, Tang W, Sheng X, Yu H, Zheng B, Xiao C
J Genet Genomics. 2011
PubMed ID: 21530900
Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1.
Cheng CJ, Huang CL
J Am Soc Nephrol. 2011
PubMed ID: 21355052
IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.
Yang D, Li Q, So I, Huang CL, Ando H, Mizutani A, Seki G, Mikoshiba K, Thomas PJ, Muallem S
J Clin Invest. 2011
PubMed ID: 21317537
Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models.
Liu Z, Xie J, Wu T, Truong T, Auchus RJ, Huang CL
Hum Mol Genet. 2011
PubMed ID: 21131289
WNK1 is required for mitosis and abscission.
Tu SW, Bugde A, Luby-Phelps K, Cobb MH
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21220314
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Protein kinase WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex.
Mendes AI, Matos P, Moniz S, Jordan P
J Biol Chem. 2010
PubMed ID: 20937822
Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.
Hadchouel J, Soukaseum C, Büsst C, Zhou XO, Baudrie V, Zürrer T, Cambillau M, Elghozi JL, Lifton RP, Loffing J, Jeunemaitre X
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20921400
A human MAP kinase interactome.
Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
Nat Methods. 2010
PubMed ID: 20936779
Regulation of WNK1 expression by miR-192 and aldosterone.
Elvira-Matelot E, Zhou XO, Farman N, Beaurain G, Henrion-Caude A, Hadchouel J, Jeunemaitre X
J Am Soc Nephrol. 2010
PubMed ID: 20813867
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.
Heise CJ, Xu BE, Deaton SL, Cha SK, Cheng CJ, Earnest S, Sengupta S, Juang YC, Stippec S, Xu Y, Zhao Y, Huang CL, Cobb MH
J Biol Chem. 2010
PubMed ID: 20525693
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
Failure to validate association between 12p13 variants and ischemic stroke.
International Stroke Genetics Consortium, Wellcome Trust Case-Control Consortium 2
N Engl J Med. 2010
PubMed ID: 20410525
TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells.
Vanderwerf SM, Svahn J, Olson S, Rathbun RK, Harrington C, Yates J, Keeble W, Anderson DC, Anur P, Pereira NF, Pilonetto DV, Pasquini R, Bagby GC
Blood. 2009
PubMed ID: 19850743
Kinetic mechanism and inhibitor characterization of WNK1 kinase.
Yagi YI, Abe K, Ikebukuro K, Sode K
Biochemistry. 2009
PubMed ID: 19739668
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation.
Rotthier A, Baets J, De Vriendt E, Jacobs A, Auer-Grumbach M, Lévy N, Bonello-Palot N, Kilic SS, Weis J, Nascimento A, Swinkels M, Kruyt MC, Jordanova A, De Jonghe P, Timmerman V
Brain. 2009
PubMed ID: 19651702
Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice.
Xie J, Wu T, Xu K, Huang IK, Cleaver O, Huang CL
Am J Pathol. 2009
PubMed ID: 19644017
Variations in the WNK1 gene modulates the effect of dietary intake of sodium and potassium on blood pressure determination.
Osada Y, Miyauchi R, Goda T, Kasezawa N, Horiike H, Iida M, Sasaki S, Yamakawa-Kobayashi K
J Hum Genet. 2009
PubMed ID: 19609280
LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension.
Zhang Z, Xu X, Zhang Y, Zhou J, Yu Z, He C
J Biol Chem. 2009
PubMed ID: 19363035
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase.
Liu Z, Wang HR, Huang CL
J Biol Chem. 2009
PubMed ID: 19244242
Docking motif-guided mapping of the interactome of protein phosphatase-1.
Hendrickx A, Beullens M, Ceulemans H, Den Abt T, Van Eynde A, Nicolaescu E, Lesage B, Bollen M
Chem Biol. 2009
PubMed ID: 19389623
[Mutations in the HSN2 exon of WNK1 cause hereditary sensory neuropathy type II]
Rivière JB, Dion P, Shekarabi M, Girard N, Faivre L, Lafrenière RG, Samuels M, Rouleau GA
Med Sci (Paris). 2009
PubMed ID: 19361385
Carriers of recessive WNK1/HSN2 mutations for hereditary sensory and autonomic neuropathy type 2 (HSAN2) are more sensitive to thermal stimuli.
Loggia ML, Bushnell MC, Tétreault M, Thiffault I, Bhérer C, Mohammed NK, Kuchinad AA, Laferrière A, Dicaire MJ, Loisel L, Mogil JS, Brais B
J Neurosci. 2009
PubMed ID: 19228968
Regulation of a third conserved phosphorylation site in SGK1.
Chen W, Chen Y, Xu BE, Juang YC, Stippec S, Zhao Y, Cobb MH
J Biol Chem. 2009
PubMed ID: 19068477
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.
Newhouse S, Farrall M, Wallace C, Hoti M, Burke B, Howard P, Onipinla A, Lee K, Shaw-Hawkins S, Dobson R, Brown M, Samani NJ, Dominiczak AF, Connell JM, Lathrop GM, Kooner J, Chambers J, Elliott P, Clarke R, Collins R, Laan M, Org E, Juhanson P, Veldre G, Viigimaa M, Eyheramendy S, Cappuccio FP, Ji C, Iacone R, Strazzullo P, Kumari M, Marmot M, Brunner E, Caulfield M, Munroe PB
PLoS One. 2009
PubMed ID: 19347040
The phagosomal proteome in interferon-gamma-activated macrophages.
Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P
Immunity. 2009
PubMed ID: 19144319
Aldosterone, but not increased Na+ influx or NF-kappaB activation, increases kidney-specific WNK1 gene expression in renal collecting duct cells.
Vinciguerra M
Horm Metab Res. 2009
PubMed ID: 18956300
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone.
Vallon V
Kidney Int. 2008
PubMed ID: 19008908
Deletion of WNK1 first intron results in misregulation of both isoforms in renal and extrarenal tissues.
Delaloy C, Elvira-Matelot E, Clemessy M, Zhou XO, Imbert-Teboul M, Houot AM, Jeunemaitre X, Hadchouel J
Hypertension. 2008
PubMed ID: 18955660
Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children.
Tobin MD, Timpson NJ, Wain LV, Ring S, Jones LR, Emmett PM, Palmer TM, Ness AR, Samani NJ, Smith GD, Burton PR
Hypertension. 2008
PubMed ID: 18809789
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation.
Manunta P, Lavery G, Lanzani C, Braund PS, Simonini M, Bodycote C, Zagato L, Delli Carpini S, Tantardini C, Brioni E, Bianchi G, Samani NJ
Hypertension. 2008
PubMed ID: 18591455
Domains of WNK1 kinase in the regulation of ROMK1.
Wang HR, Liu Z, Huang CL
Am J Physiol Renal Physiol. 2008
PubMed ID: 18550644
Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II.
Shekarabi M, Girard N, Rivière JB, Dion P, Houle M, Toulouse A, Lafrenière RG, Vercauteren F, Hince P, Laganiere J, Rochefort D, Faivre L, Samuels M, Rouleau GA
J Clin Invest. 2008
PubMed ID: 18521183
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR
J Proteome Res. 2008
PubMed ID: 18220336
WNK kinases, renal ion transport and hypertension.
San-Cristobal P, de los Heros P, Ponce-Coria J, Moreno E, Gamba G
Am J Nephrol. 2008
PubMed ID: 18547946
The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.
Yang CL, Zhu X, Ellison DH
J Clin Invest. 2007
PubMed ID: 17975670
Mechanisms of disease: WNK-ing at the mechanism of salt-sensitive hypertension.
Huang CL, Kuo E
Nat Clin Pract Nephrol. 2007
PubMed ID: 17957199
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD
J Proteome Res. 2007
PubMed ID: 17924679
Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.
Tang LY, Deng N, Wang LS, Dai J, Wang ZL, Jiang XS, Li SJ, Li L, Sheng QH, Wu DQ, Li L, Zeng R
Mol Cell Proteomics. 2007
PubMed ID: 17693683
Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway.
Lee BH, Chen W, Stippec S, Cobb MH
J Biol Chem. 2007
PubMed ID: 17392271
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ
Science. 2007
PubMed ID: 17525332
Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors.
You KT, Li LS, Kim NG, Kang HJ, Koh KH, Chwae YJ, Kim KM, Kim YK, Park SM, Jang SK, Kim H
PLoS Biol. 2007
PubMed ID: 17456004
Intersectin links WNK kinases to endocytosis of ROMK1.
He G, Wang HR, Huang SK, Huang CL
J Clin Invest. 2007
PubMed ID: 17380208
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
The Krüppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway.
Kim YS, Kang HS, Jetten AM
FEBS Lett. 2007
PubMed ID: 17289029
WNK1 and WNK4 modulate CFTR activity.
Yang CL, Liu X, Paliege A, Zhu X, Bachmann S, Dawson DC, Ellison DH
Biochem Biophys Res Commun. 2007
PubMed ID: 17194447
Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress.
Zagórska A, Pozo-Guisado E, Boudeau J, Vitari AC, Rafiqi FH, Thastrup J, Deak M, Campbell DG, Morrice NA, Prescott AR, Alessi DR
J Cell Biol. 2007
PubMed ID: 17190791
Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved.
Golbang AP, Cope G, Hamad A, Murthy M, Liu CH, Cuthbert AW, O'shaughnessy KM
Am J Physiol Renal Physiol. 2006
PubMed ID: 16788137
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Down-regulation of WNK1 protein kinase in neural progenitor cells suppresses cell proliferation and migration.
Sun X, Gao L, Yu RK, Zeng G
J Neurochem. 2006
PubMed ID: 17018027
Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells.
Ohta A, Yang SS, Rai T, Chiga M, Sasaki S, Uchida S
Biochem Biophys Res Commun. 2006
PubMed ID: 16949040
The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
Science. 2006
PubMed ID: 16959974
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP
Nat Biotechnol. 2006
PubMed ID: 16964243
Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.
O'Reilly M, Marshall E, Macgillivray T, Mittal M, Xue W, Kenyon CJ, Brown RW
J Am Soc Nephrol. 2006
PubMed ID: 16899520
WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron.
Subramanya AR, Yang CL, McCormick JA, Ellison DH
Kidney Int. 2006
PubMed ID: 16820787
WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.
Anselmo AN, Earnest S, Chen W, Juang YC, Kim SC, Zhao Y, Cobb MH
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16832045
Cardiovascular expression of the mouse WNK1 gene during development and adulthood revealed by a BAC reporter assay.
Delaloy C, Hadchouel J, Imbert-Teboul M, Clemessy M, Houot AM, Jeunemaitre X
Am J Pathol. 2006
PubMed ID: 16816365
WNK1 affects surface expression of the ROMK potassium channel independent of WNK4.
Cope G, Murthy M, Golbang AP, Hamad A, Liu CH, Cuthbert AW, O'Shaughnessy KM
J Am Soc Nephrol. 2006
PubMed ID: 16775035
Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.
Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HK, Alessi DR
Biochem J. 2006
PubMed ID: 16669787
WNK kinases influence TRPV4 channel function and localization.
Fu Y, Subramanya A, Rozansky D, Cohen DM
Am J Physiol Renal Physiol. 2006
PubMed ID: 16403833
Regulation of cellular functions by the ERK5 signalling pathway.
Wang X, Tournier C
Cell Signal. 2006
PubMed ID: 16376520
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY
Cell. 2006
PubMed ID: 16713569
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
The finished DNA sequence of human chromosome 12.
Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA, Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
Nature. 2006
PubMed ID: 16541075
Novel mutations in the HSN2 gene causing hereditary sensory and autonomic neuropathy type II.
Coen K, Pareyson D, Auer-Grumbach M, Buyse G, Goemans N, Claeys KG, Verpoorten N, Laurà M, Scaioli V, Salmhofer W, Pieber TR, Nelis E, De Jonghe P, Timmerman V
Neurology. 2006
PubMed ID: 16534117
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform.
Subramanya AR, Yang CL, Zhu X, Ellison DH
Am J Physiol Renal Physiol. 2006
PubMed ID: 16204408
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.
Lazrak A, Liu Z, Huang CL
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16428287
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.
Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H
J Biol Chem. 2005
PubMed ID: 16263722
Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population.
Tobin MD, Raleigh SM, Newhouse S, Braund P, Bodycote C, Ogleby J, Cross D, Gracey J, Hayes S, Smith T, Ridge C, Caulfield M, Sheehan NA, Munroe PB, Burton PR, Samani NJ
Circulation. 2005
PubMed ID: 16301342
WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic.
Turner ST, Schwartz GL, Chapman AB, Boerwinkle E
Hypertension. 2005
PubMed ID: 16172412
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.
Vitari AC, Deak M, Morrice NA, Alessi DR
Biochem J. 2005
PubMed ID: 16083423
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Properties of WNK1 and implications for other family members.
Lenertz LY, Lee BH, Min X, Xu BE, Wedin K, Earnest S, Goldsmith EJ, Cobb MH
J Biol Chem. 2005
PubMed ID: 15883153
Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.
Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP
J Biol Chem. 2005
PubMed ID: 15799971
Two mutations in the HSN2 gene explain the high prevalence of HSAN2 in French Canadians.
Roddier K, Thomas T, Marleau G, Gagnon AM, Dicaire MJ, St-Denis A, Gosselin I, Sarrazin AM, Larbrisseau A, Lambert M, Vanasse M, Gaudet D, Rouleau GA, Brais B
Neurology. 2005
PubMed ID: 15911806
Expression of the mouse WNK1 gene in correlation with ganglioside GD3 and functional analysis of the mouse WNK1 promoter.
Zeng G, Gao L, Xia T, Gu Y, Yu RK
Gene. 2005
PubMed ID: 15656989
WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension.
Xu BE, Lee BH, Min X, Lenertz L, Heise CJ, Stippec S, Goldsmith EJ, Cobb MH
Cell Res. 2005
PubMed ID: 15686619
A neurogenomics approach to gene expression analysis in the developing brain.
Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T
Brain Res Mol Brain Res. 2004
PubMed ID: 15582152
The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport.
Náray-Fejes-Tóth A, Snyder PM, Fejes-Tóth G
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15583131
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
A mutation in the HSN2 gene causes sensory neuropathy type II in a Lebanese family.
Rivière JB, Verlaan DJ, Shekarabi M, Lafrenière RG, Bénard M, Der Kaloustian VM, Shbaklo Z, Rouleau GA
Ann Neurol. 2004
PubMed ID: 15455397
WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.
Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH
Mol Cell. 2004
PubMed ID: 15350218
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T
Curr Biol. 2004
PubMed ID: 15324660
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension.
Min X, Lee BH, Cobb MH, Goldsmith EJ
Structure. 2004
PubMed ID: 15242606
Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.
Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL
Genomics. 2004
PubMed ID: 15203218
Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Okazaki N, F-Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H, Nagase T, Ohara O, Koga H
DNA Res. 2004
PubMed ID: 15368895
Comparison of WNK4 and WNK1 kinase and inhibiting activities.
Wang Z, Yang CL, Ellison DH
Biochem Biophys Res Commun. 2004
PubMed ID: 15081430
Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates.
Lafreniere RG, MacDonald ML, Dube MP, MacFarlane J, O'Driscoll M, Brais B, Meilleur S, Brinkman RR, Dadivas O, Pape T, Platon C, Radomski C, Risler J, Thompson J, Guerra-Escobio AM, Davar G, Breakefield XO, Pimstone SN, Green R, Pryse-Phillips W, Goldberg YP, Younghusband HB, Hayden MR, Sherrington R, Rouleau GA, Samuels ME, Study of Canadian Genetic Isolates
Am J Hum Genet. 2004
PubMed ID: 15060842
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
WNK1 activates ERK5 by an MEKK2/3-dependent mechanism.
Xu BE, Stippec S, Lenertz L, Lee BH, Zhang W, Lee YK, Cobb MH
J Biol Chem. 2004
PubMed ID: 14681216
WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate.
Vitari AC, Deak M, Collins BJ, Morrice N, Prescott AR, Phelan A, Humphreys S, Alessi DR
Biochem J. 2004
PubMed ID: 14611643
Transcriptome analysis of mouse stem cells and early embryos.
Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, Falco G, Martin PR, Stagg CA, Bassey UC, Wang Y, Carter MG, Hamatani T, Aiba K, Akutsu H, Sharova L, Tanaka TS, Kimber WL, Yoshikawa T, Jaradat SA, Pantano S, Nagaraja R, Boheler KR, Taub D, Hodes RJ, Longo DL, Schlessinger D, Keller J, Klotz E, Kelsoe G, Umezawa A, Vescovi AL, Rossant J, Kunath T, Hogan BL, Curci A, D'Urso M, Kelso J, Hide W, Ko MS
PLoS Biol. 2003
PubMed ID: 14691545
Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform.
Delaloy C, Lu J, Houot AM, Disse-Nicodeme S, Gasc JM, Corvol P, Jeunemaitre X
Mol Cell Biol. 2003
PubMed ID: 14645531
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain.
O'Reilly M, Marshall E, Speirs HJ, Brown RW
J Am Soc Nephrol. 2003
PubMed ID: 14514722
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor.
Giangrande PH, Hallstrom TC, Tunyaplin C, Calame K, Nevins JR
Mol Cell Biol. 2003
PubMed ID: 12748276
WNK kinases regulate thiazide-sensitive Na-Cl cotransport.
Yang CL, Angell J, Mitchell R, Ellison DH
J Clin Invest. 2003
PubMed ID: 12671053
WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.
Choate KA, Kahle KT, Wilson FH, Nelson-Williams C, Lifton RP
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12522152
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Regulation of WNK1 by an autoinhibitory domain and autophosphorylation.
Xu BE, Min X, Stippec S, Lee BH, Goldsmith EJ, Cobb MH
J Biol Chem. 2002
PubMed ID: 12374799
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T
DNA Res. 2002
PubMed ID: 12168954
WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.
Veríssimo F, Jordan P
Oncogene. 2001
PubMed ID: 11571656
Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Piao Y, Ko NT, Lim MK, Ko MS
Genome Res. 2001
PubMed ID: 11544199
Human hypertension caused by mutations in WNK kinases.
Wilson FH, Disse-Nicodème S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP
Science. 2001
PubMed ID: 11498583
Functional annotation of a full-length mouse cDNA collection.
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Model Organism Phenotype Links from MGI Top Help

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	Human	Mouse	Rat
Entrez Gene	65125	232341	116477
EnsEMBL Gene(s)	ENSG00000060237	ENSMUSG00000045962	ENSRNOG00000009956
Unigene	Hs.731621	Mm.333349	Rn.27409
Homologene	WNK1	Wnk1	Wnk1
OMIM	605232	N/A	N/A
GeneCards	WNK1	N/A	N/A
Beta Cell Genomics	DT.100044219 DT.404388 DT.87018079 DT.91975018 DT.92459672 DT.92459680	DT.101149911 DT.101270008 DT.102557034 DT.110487245 DT.532359 DT.91592618 DT.94159817 DT.94369252	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	65125	232341	116477

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Interactor	Interactor	Sources	Classification	Pubmed IDs
WNK1	CHAF1A	IntAct	empirical	20936779
WNK1	RANBP9	BioGRID	empirical	20936779
WNK1	MPHOSPH9	IntAct	empirical	20936779
WNK1	MAP3K2	HPRD	empirical	14681216
WNK1	COPS5	IntAct, BioGRID	empirical	20936779
WNK1	SYNPO	IntAct	empirical	20936779
WNK1	SYT2	HPRD, IntAct	empirical	15350218
WNK1	SYT9	IntAct	empirical	15350218
WNK1	SYNPO2	IntAct	empirical	20936779
WNK1	E2F3	BioGRID	empirical	12748276
WNK1	EPB41L2	IntAct	empirical	20936779
WNK1	AKT1	HPRD	empirical	14611643
WNK1	RAP1GAP2	IntAct	empirical	20936779
WNK1	FLNC	BioGRID	empirical	20936779
WNK1	NEDD4L	IntAct	empirical	20936779
WNK1	WWTR1	IntAct	empirical	20936779
WNK1	TNRC6A	BioGRID	empirical	20936779
WNK1	FHOD1	IntAct	empirical	20936779
WNK1	HIVEP2	IntAct	empirical	20936779
WNK1	ARAF	IntAct	empirical	21988832
WNK1	C5orf25	IntAct	empirical	20936779
WNK1	LCP2	IntAct	empirical	20936779
WNK1	LRMP	IntAct	empirical	20936779
WNK1	ME2	IntAct	empirical	17353931
WNK1	MAP3K3	HPRD	empirical	14681216
WNK1	ATP8	BioGRID	empirical	20936779
WNK1	MYH9	IntAct	empirical	20936779
WNK1	FAM13B	IntAct	empirical	20936779
WNK1	FAM53C	IntAct	empirical	20936779
WNK1	PFKP	IntAct	empirical	21988832
WNK1	PPP1CA	IntAct	empirical	19389623
WNK1	MSL2	IntAct	empirical	20936779
WNK1	FAM82A2	IntAct	empirical	20936779
WNK1	PRKAR1B	BioGRID	empirical	20936779
WNK1	ZNF839	IntAct	empirical	20936779
WNK1	CENPJ	IntAct	empirical	20936779
WNK1	MAP2K1	IntAct, BioGRID	empirical	20936779
WNK1	BAD	IntAct	empirical	20936779
WNK1	PVR	IntAct	empirical	21988832
WNK1	ATXN1	HPRD, MINT, IntAct	empirical	16713569
WNK1	RASAL3	IntAct	empirical	20936779
WNK1	WNK1	IntAct, BioGRID	empirical	20936779
WNK1	WNK2	IntAct, BioGRID	empirical	20936779
WNK1	SLC9A1	BioGRID	empirical	20936779
WNK1	SSFA2	IntAct	empirical	20936779
WNK1	SYT1	IntAct	empirical	15350218
WNK1	TNFAIP3	IntAct	empirical	20936779
WNK1	TNS1	IntAct	empirical	20936779
WNK1	UBC	BioGRID	empirical	19850743 21139048
WNK1	YWHAE	IntAct, BioGRID	empirical	20936779
WNK1	YWHAG	HPRD, IntAct, BioGRID	empirical	15324660 20936779
WNK1	YWHAZ	IntAct, BioGRID	empirical	20936779
WNK1	ZYX	BioGRID	empirical	20936779
WNK1	CSDE1	BioGRID	empirical	20936779
WNK1	SYT3	IntAct	empirical	15350218
WNK1	GLIS2	MINT, BioGRID	empirical	17289029
WNK1	CGNL1	IntAct	empirical	20936779
WNK1	MADD	IntAct	empirical	20936779
WNK1	EIF3A	IntAct	empirical	20936779
WNK1	TSC22D1	BioGRID	empirical	20936779
WNK1	BAG3	BioGRID	empirical	20936779
WNK1	HDAC9	IntAct	empirical	20936779
WNK1	FAM65B	IntAct	empirical	20936779
WNK1	KIAA0232	IntAct	empirical	20936779
WNK1	OXSR1	MINT	empirical	17721439