BMP1
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(Human) GRCh37 - chr8:22022249..22069840 (47.59 kb) View in Genome Browser
(Mouse) NCBIM37 - chr14:70874362..70920067 (45.70 kb) View in Genome Browser
(Rat) RGSC3.4 - chr15:50878144..50922313 (44.17 kb) View in Genome Browser
HaemAtlas Expression Table for BMP1:
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for BMP1:The BMP1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| BMP1 | COL1A1 | HPRD | empirical | 11283002 |
| BMP1 | COL5A1 | HPRD | empirical | 11741999 |
| BMP1 | COL5A2 | HPRD | empirical | 11741999 |
| BMP1 | COL7A1 | HPRD | empirical | 11986329 |
| BMP1 | ADRA1A | HPRD, IntAct | empirical | 15525470 |
| BMP1 | GEM | IntAct | empirical | 18624398 |
| BMP1 | HSPG2 | HPRD | empirical | 15591058 |
| BMP1 | LAMA3 | HPRD | empirical | 10806203 |
| BMP1 | LAMB3 | HPRD | empirical | 10806203 |
| BMP1 | LAMC2 | HPRD | empirical | 10806203 |
| BMP1 | YLPM1 | HPRD, IntAct | empirical | 16169070 |
| BMP1 | TWSG1 | HPRD | empirical | 11260715 |
| BMP1 | SFRP2 | BioGRID | empirical | 19079247 |
| BMP1 | TP53 | IntAct | empirical | 18624398 |
| BMP1 | CHRD | HPRD, MINT | empirical | 10479448 20043912 |
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Publications: 99
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Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3.
Kim B, Huang G, Ho WB, Greenspan DS
J Biol Chem. 2011
PubMed ID: 21697095
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A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
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BMPR1A-mediated BMP1 signalling is disrupted in the cadmium-induced omphalocele in the chick model.
Doi T, Puri P, Bannigan J, Thompson J
Pediatr Surg Int. 2011
PubMed ID: 21258932
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Bone morphogenetic protein (BMP)1-3 enhances bone repair.
Grgurevic L, Macek B, Mercep M, Jelic M, Smoljanovic T, Erjavec I, Dumic-Cule I, Prgomet S, Durdevic D, Vnuk D, Lipar M, Stejskal M, Kufner V, Brkljacic J, Maticic D, Vukicevic S
Biochem Biophys Res Commun. 2011
PubMed ID: 21453682
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Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis.
Grgurevic L, Macek B, Healy DR, Brault AL, Erjavec I, Cipcic A, Grgurevic I, Rogic D, Galesic K, Brkljacic J, Stern-Padovan R, Paralkar VM, Vukicevic S
J Am Soc Nephrol. 2011
PubMed ID: 21415150
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Interaction of TGFβ and BMP signaling pathways during chondrogenesis.
Keller B, Yang T, Chen Y, Munivez E, Bertin T, Zabel B, Lee B
PLoS One. 2011
PubMed ID: 21297990
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Somatic frameshift mutations of bone morphogenic protein receptor 2 gene in gastric and colorectal cancers with microsatellite instability.
Park SW, Hur SY, Yoo NJ, Lee SH
APMIS. 2010
PubMed ID: 20955454
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Skeletal muscle expression of bone morphogenetic protein-1 and tolloid-like-1 extracellular proteases in different fiber types and in response to unloading, food deprivation and differentiation.
Allen DL, Greybeck BJ, Greyback BJ, Hanson AM, Cleary AS, Lindsay SF
J Physiol Sci. 2010
PubMed ID: 20658214
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Genetic evidence that SOST inhibits WNT signaling in the limb.
Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG
Dev Biol. 2010
PubMed ID: 20359476
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The basic helix-loop-helix transcription factor Nato3 controls neurogenic activity in mesencephalic floor plate cells.
Ono Y, Nakatani T, Minaki Y, Kumai M
Development. 2010
PubMed ID: 20460368
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Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase.
Maruhashi T, Kii I, Saito M, Kudo A
J Biol Chem. 2010
PubMed ID: 20181949
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New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
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Decorin is processed by three isoforms of bone morphogenetic protein-1 (BMP1).
von Marschall Z, Fisher LW
Biochem Biophys Res Commun. 2010
PubMed ID: 20026052
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Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.
Ikeya M, Fukushima K, Kawada M, Onishi S, Furuta Y, Yonemura S, Kitamura T, Nosaka T, Sasai Y
Dev Biol. 2010
PubMed ID: 19914233
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Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer)
PLoS Genet. 2010
PubMed ID: 20628624
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Strong cooperativity and loose geometry between CUB domains are the basis for procollagen c-proteinase enhancer activity.
Kronenberg D, Vadon-Le Goff S, Bourhis JM, Font B, Eichenberger D, Hulmes DJ, Moali C
J Biol Chem. 2009
PubMed ID: 19801683
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Fibronectin binds and enhances the activity of bone morphogenetic protein 1.
Huang G, Zhang Y, Kim B, Ge G, Annis DS, Mosher DF, Greenspan DS
J Biol Chem. 2009
PubMed ID: 19617627
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Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma.
Bai Y, Zhou G, Nakamura M, Ozaki T, Mori I, Taniguchi E, Miyauchi A, Ito Y, Kakudo K
Mod Pathol. 2009
PubMed ID: 19305382
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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[Changes of mRNAs encoding alternatively spliced variants of procollagen C-endopeptidase in leiomyomas uteri depending on the phase of menstrual cycle and in postmenopausal women]
Auguściak-Duma A, Kajor M, Piwowarczyk M, Sikora J, Sieron AL
Ginekol Pol. 2009
PubMed ID: 19323056
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Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction.
Kobayashi K, Luo M, Zhang Y, Wilkes DC, Ge G, Grieskamp T, Yamada C, Liu TC, Huang G, Basson CT, Kispert A, Greenspan DS, Sato TN
Nat Cell Biol. 2009
PubMed ID: 19079247
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Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.
Mac Sweeney A, Gil-Parrado S, Vinzenz D, Bernardi A, Hein A, Bodendorf U, Erbel P, Logel C, Gerhartz B
J Mol Biol. 2008
PubMed ID: 18824173
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Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
Wang J, Yuan Y, Zhou Y, Guo L, Zhang L, Kuai X, Deng B, Pan Z, Li D, He F
J Proteome Res. 2008
PubMed ID: 18624398
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Bone morphogenetic proteins are overexpressed in the bone marrow of primary myelofibrosis and are apparently induced by fibrogenic cytokines.
Bock O, Höftmann J, Theophile K, Hussein K, Wiese B, Schlué J, Kreipe H
Am J Pathol. 2008
PubMed ID: 18349123
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GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
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Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins.
Nahar NN, Missana LR, Garimella R, Tague SE, Anderson HC
J Bone Miner Metab. 2008
PubMed ID: 18758911
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Genetic analysis of the role of proteolysis in the activation of latent myostatin.
Lee SJ
PLoS ONE. 2008
PubMed ID: 18286185
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Vascular Bmp Msx2 Wnt signaling and oxidative stress in arterial calcification.
Shao JS, Aly ZA, Lai CF, Cheng SL, Cai J, Huang E, Behrmann A, Towler DA
Ann N Y Acad Sci. 2007
PubMed ID: 18056036
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Enzymatic cleavage specificity of the proalpha1(V) chain processing analysed by site-directed mutagenesis.
Bonod-Bidaud C, Beraud M, Vaganay E, Delacoux F, Font B, Hulmes DJ, Ruggiero F
Biochem J. 2007
PubMed ID: 17407447
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Bone morphogenetic protein 1 processes prolactin to a 17-kDa antiangiogenic factor.
Ge G, Fernández CA, Moses MA, Greenspan DS
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17548836
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The protease domain of procollagen C-proteinase (BMP1) lacks substrate selectivity, which is conferred by non-proteolytic domains.
Wermter C, Höwel M, Hintze V, Bombosch B, Aufenvenne K, Yiallouros I, Stöcker W
Biol Chem. 2007
PubMed ID: 17516847
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BMP signaling mutant mice exhibit glial cell maturation defects.
See J, Mamontov P, Ahn K, Wine-Lee L, Crenshaw EB, Grinspan JB
Mol Cell Neurosci. 2007
PubMed ID: 17391983
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Bone morphogenetic protein 1 prodomain specifically binds and regulates signaling by bone morphogenetic proteins 2 and 4.
Jasuja R, Ge G, Voss NG, Lyman-Gingerich J, Branam AM, Pelegri FJ, Greenspan DS
J Biol Chem. 2007
PubMed ID: 17255107
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Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.
Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC
Atherosclerosis. 2007
PubMed ID: 16806233
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Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin.
Zhang Y, Ge G, Greenspan DS
J Biol Chem. 2006
PubMed ID: 17071617
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The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
Science. 2006
PubMed ID: 16959974
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BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein.
Ge G, Greenspan DS
J Cell Biol. 2006
PubMed ID: 17015622
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bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis.
Jasuja R, Voss N, Ge G, Hoffman GG, Lyman-Gingerich J, Pelegri F, Greenspan DS
Mech Dev. 2006
PubMed ID: 16824737
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Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains.
Ge G, Zhang Y, Steiglitz BM, Greenspan DS
J Biol Chem. 2006
PubMed ID: 16507574
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BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
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DNA sequence and analysis of human chromosome 8.
Nusbaum C, Mikkelsen TS, Zody MC, Asakawa S, Taudien S, Garber M, Kodira CD, Schueler MG, Shimizu A, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Allen NR, Anderson S, Asakawa T, Blechschmidt K, Bloom T, Borowsky ML, Butler J, Cook A, Corum B, DeArellano K, DeCaprio D, Dooley KT, Dorris L, Engels R, Glöckner G, Hafez N, Hagopian DS, Hall JL, Ishikawa SK, Jaffe DB, Kamat A, Kudoh J, Lehmann R, Lokitsang T, Macdonald P, Major JE, Matthews CD, Mauceli E, Menzel U, Mihalev AH, Minoshima S, Murayama Y, Naylor JW, Nicol R, Nguyen C, O'Leary SB, O'Neill K, Parker SC, Polley A, Raymond CK, Reichwald K, Rodriguez J, Sasaki T, Schilhabel M, Siddiqui R, Smith CL, Sneddon TP, Talamas JA, Tenzin P, Topham K, Venkataraman V, Wen G, Yamazaki S, Young SK, Zeng Q, Zimmer AR, Rosenthal A, Birren BW, Platzer M, Shimizu N, Lander ES
Nature. 2006
PubMed ID: 16421571
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Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
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A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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The BMP signaling and in vivo bone formation.
Cao X, Chen D
Gene. 2005
PubMed ID: 16125875
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Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1).
Petropoulou V, Garrigue-Antar L, Kadler KE
J Biol Chem. 2005
PubMed ID: 15817489
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BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan.
Gonzalez EM, Reed CC, Bix G, Fu J, Zhang Y, Gopalakrishnan B, Greenspan DS, Iozzo RV
J Biol Chem. 2005
PubMed ID: 15591058
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Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability.
Williams TM, Williams ME, Heaton JH, Gelehrter TD, Innis JW
Nucleic Acids Res. 2005
PubMed ID: 16087734
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Proliferative activity of extracellular HIV-1 Tat protein in human epithelial cells: expression profile of pathogenetically relevant genes.
Bettaccini AA, Baj A, Accolla RS, Basolo F, Toniolo AQ
BMC Microbiol. 2005
PubMed ID: 15857508
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Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
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Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors.
Zhang T, Xu Q, Chen FR, Han QD, Zhang YY
Acta Pharmacol Sin. 2004
PubMed ID: 15525470
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis.
Ge G, Seo NS, Liang X, Hopkins DR, Höök M, Greenspan DS
J Biol Chem. 2004
PubMed ID: 15292192
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Molecular, histologic, and gross phenotype of skin wound healing in red Duroc pigs reveals an abnormal healing phenotype of hypercontracted, hyperpigmented scarring.
Gallant CL, Olson ME, Hart DA
Wound Repair Regen. 2004
PubMed ID: 15225209
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IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis.
Sil AK, Maeda S, Sano Y, Roop DR, Karin M
Nature. 2004
PubMed ID: 15071597
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
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An unappreciated role for RNA surveillance.
Hillman RT, Green RE, Brenner SE
Genome Biol. 2004
PubMed ID: 14759258
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
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Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases.
Pappano WN, Steiglitz BM, Scott IC, Keene DR, Greenspan DS
Mol Cell Biol. 2003
PubMed ID: 12808086
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Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network.
Leighton M, Kadler KE
J Biol Chem. 2003
PubMed ID: 12637569
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Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity.
Hartigan N, Garrigue-Antar L, Kadler KE
J Biol Chem. 2003
PubMed ID: 12637537
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1.
Steiglitz BM, Keene DR, Greenspan DS
J Biol Chem. 2002
PubMed ID: 12393877
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms.
Hoffman MP, Kidder BL, Steinberg ZL, Lakhani S, Ho S, Kleinman HK, Larsen M
Development. 2002
PubMed ID: 12421715
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Post-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the protein.
Garrigue-Antar L, Hartigan N, Kadler KE
J Biol Chem. 2002
PubMed ID: 12218058
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Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen.
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J Biol Chem. 2002
PubMed ID: 11986329
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Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases.
Unsöld C, Pappano WN, Imamura Y, Steiglitz BM, Greenspan DS
J Biol Chem. 2002
PubMed ID: 11741999
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Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity.
Garrigue-Antar L, Barker C, Kadler KE
J Biol Chem. 2001
PubMed ID: 11283002
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Genetic loci influencing natural variations in femoral bone morphometry in mice.
Drake TA, Hannani K, Kabo JM, Villa V, Krass K, Lusis AJ
J Orthop Res. 2001
PubMed ID: 11518254
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Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling.
Scott IC, Blitz IL, Pappano WN, Maas SA, Cho KW, Greenspan DS
Nature. 2001
PubMed ID: 11260715
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos.
Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG
Mech Dev. 2000
PubMed ID: 11044609
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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Bone morphogenetic protein-1 processes probiglycan.
Scott IC, Imamura Y, Pappano WN, Troedel JM, Recklies AD, Roughley PJ, Greenspan DS
J Biol Chem. 2000
PubMed ID: 10896944
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Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
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Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain.
Amano S, Scott IC, Takahara K, Koch M, Champliaud MF, Gerecke DR, Keene DR, Hudson DL, Nishiyama T, Lee S, Greenspan DS, Burgeson RE
J Biol Chem. 2000
PubMed ID: 10806203
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Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.
Scott IC, Blitz IL, Pappano WN, Imamura Y, Clark TG, Steiglitz BM, Thomas CL, Maas SA, Takahara K, Cho KW, Greenspan DS
Dev Biol. 1999
PubMed ID: 10479448
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Limbiting outgrowth: BMPs as negative regulators in limb development.
Dahn RD, Fallon JF
Bioessays. 1999
PubMed ID: 10462412
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The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart.
Clark TG, Conway SJ, Scott IC, Labosky PA, Winnier G, Bundy J, Hogan BL, Greenspan DS
Development. 1999
PubMed ID: 10331975
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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Three alternatively spliced variants of the gene coding for the human bone morphogenetic protein-1.
Janitz M, Heiser V, Böttcher U, Landt O, Lauster R
J Mol Med. 1998
PubMed ID: 9500680
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Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid.
Suzuki N, Labosky PA, Furuta Y, Hargett L, Dunn R, Fogo AB, Takahara K, Peters DM, Greenspan DS, Hogan BL
Development. 1996
PubMed ID: 8951074
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Updating the metalloprotease nomenclature: bone morphogenetic protein 1 identified as procollagen C proteinase.
Hofbauer LC, Heufelder AE
Eur J Endocrinol. 1996
PubMed ID: 8765971
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Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1.
Takahara K, Brevard R, Hoffman GG, Suzuki N, Greenspan DS
Genomics. 1996
PubMed ID: 8661043
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The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1.
Li SW, Sieron AL, Fertala A, Hojima Y, Arnold WV, Prockop DJ
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8643539
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Bone morphogenetic protein-1: the type I procollagen C-proteinase.
Kessler E, Takahara K, Biniaminov L, Brusel M, Greenspan DS
Science. 1996
PubMed ID: 8553073
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Structural organization and genetic localization of the human bone morphogenetic protein 1/mammalian tolloid gene.
Takahara K, Lee S, Wood S, Greenspan DS
Genomics. 1995
PubMed ID: 8530106
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Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues.
Takahara K, Lyons GE, Greenspan DS
J Biol Chem. 1994
PubMed ID: 7798260
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Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1), which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase.
Fukagawa M, Suzuki N, Hogan BL, Jones CM
Dev Biol. 1994
PubMed ID: 8174772
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HNF-3 beta as a regulator of floor plate development.
Sasaki H, Hogan BL
Cell. 1994
PubMed ID: 8287471
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Mapping of the bone morphogenetic protein 1 gene (BMP1) to 8p21: removal of BMP1 from candidacy for the bone disorder in Langer-Giedion syndrome.
Yoshiura K, Tamura T, Hong HS, Ohta T, Soejima H, Kishino T, Jinno Y, Niikawa N
Cytogenet Cell Genet. 1993
PubMed ID: 8404039
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A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus.
Jackson IJ, Chambers DM, Tsukamoto K, Copeland NG, Gilbert DJ, Jenkins NA, Hearing V
EMBO J. 1992
PubMed ID: 1537334
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Chromosomal localization of three pulmonary surfactant protein genes in the mouse.
Moore KJ, D'Amore-Bruno MA, Korfhagen TR, Glasser SW, Whitsett JA, Jenkins NA, Copeland NG
Genomics. 1992
PubMed ID: 1346779
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Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3.
Tabas JA, Zasloff M, Wasmuth JJ, Emanuel BS, Altherr MR, McPherson JD, Wozney JM, Kaplan FS
Genomics. 1991
PubMed ID: 2004778
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An interspecific backcross linkage map of the proximal half of mouse chromosome 14.
Ceci JD, Kingsley DM, Silan CM, Copeland NG, Jenkins NA
Genomics. 1990
PubMed ID: 1971251
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Novel regulators of bone formation: molecular clones and activities.
Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA
Science. 1988
PubMed ID: 3201241
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