BMI1

Summary Top Help

Gene Description:

Bmi1 polycomb ring finger oncogene; BMI1 polycomb ring finger oncogene

Synonyms:

FLVI2/BMI1, PCGF4, Pcgf4, BMI1, Bmi1, AW546694, RNF51, Bmi-1

Orthologs:

Human BMI1 (protein-coding), Mouse Bmi1 (protein-coding), Rat Bmi1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr10:22605381..22620414 (153 kb) View in Genome Browser

(Mouse) NCBIM37 - chr2:18598645..18608256 (9.61 kb) View in Genome Browser

(Rat) RGSC3.4 - chr17:92784216..92787947 (3.73 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for BMI1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
								no data	no data	no data	no data	no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for BMI1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: 1

Reactome: None available

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 32

Publications from PubMed Top Help

Type 1 Diabetes Publications: 3

Publications: 324

The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations.
Yan KS, Chia LA, Li X, Ootani A, Su J, Lee JY, Su N, Luo Y, Heilshorn SC, Amieva MR, Sangiorgi E, Capecchi MR, Kuo CJ
Proc Natl Acad Sci U S A. 2012
PubMed ID: 22190486
Single-molecule transcript counting of stem-cell markers in the mouse intestine.
Itzkovitz S, Lyubimova A, Blat IC, Maynard M, van Es J, Lees J, Jacks T, Clevers H, van Oudenaarden A
Nat Cell Biol. 2012
PubMed ID: 22119784
Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection.
Wu KJ, Yang MH
Biosci Rep. 2011
PubMed ID: 21919891
Collagen I regulates the self-renewal of mouse embryonic stem cells through α2β1 integrin- and DDR1-dependent Bmi-1.
Suh HN, Han HJ
J Cell Physiol. 2011
PubMed ID: 21344393
Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage.
Seo E, Basu-Roy U, Zavadil J, Basilico C, Mansukhani A
Mol Cell Biol. 2011
PubMed ID: 21930787
Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes.
Hyland PL, McDade SS, McCloskey R, Dickson GJ, Arthur K, McCance DJ, Patel D
J Virol. 2011
PubMed ID: 21865393
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable.
Tian H, Biehs B, Warming S, Leong KG, Rangell L, Klein OD, de Sauvage FJ
Nature. 2011
PubMed ID: 21927002
A high-resolution molecular atlas of the fetal mouse lower urogenital tract.
Abler LL, Keil KP, Mehta V, Joshi PS, Schmitz CT, Vezina CM
Dev Dyn. 2011
PubMed ID: 21905163
Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci.
Zacharek SJ, Fillmore CM, Lau AN, Gludish DW, Chou A, Ho JW, Zamponi R, Gazit R, Bock C, Jäger N, Smith ZD, Kim TM, Saunders AH, Wong J, Lee JH, Roach RR, Rossi DJ, Meissner A, Gimelbrant AA, Park PJ, Kim CF
Cell Stem Cell. 2011
PubMed ID: 21885022
Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.
Bentley ML, Corn JE, Dong KC, Phung Q, Cheung TK, Cochran AG
EMBO J. 2011
PubMed ID: 21772249
BMI1'S maintenance of the proliferative capacity of laryngeal cancer stem cells.
Chen H, Zhou L, Dou T, Wan G, Tang H, Tian J
Head Neck. 2011
PubMed ID: 21755556
Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells.
Yuan J, Takeuchi M, Negishi M, Oguro H, Ichikawa H, Iwama A
Leukemia. 2011
PubMed ID: 21527932
Bmi-1, c-myc, and Snail expression in primary breast cancers and their metastases--elevated Bmi-1 expression in late breast cancer relapses.
Joensuu K, Hagström J, Leidenius M, Haglund C, Andersson LC, Sariola H, Heikkilä P
Virchows Arch. 2011
PubMed ID: 21638011
Differentiation of postnatal cerebellar glial progenitors is controlled by Bmi1 through BMP pathway inhibition.
Zhang X, Santuccione A, Leung C, Marino S
Glia. 2011
PubMed ID: 21544870
Clinicopathological and prognostic significance of Bmi-1 expression in human cervical cancer.
Min L, Dong-Xiang S, Xiao-Tong G, Ting G, Xiao-Dong C
Acta Obstet Gynecol Scand. 2011
PubMed ID: 21309753
Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells.
Smith LL, Yeung J, Zeisig BB, Popov N, Huijbers I, Barnes J, Wilson AJ, Taskesen E, Delwel R, Gil J, Van Lohuizen M, So CW
Cell Stem Cell. 2011
PubMed ID: 21624810
In search of CML stem cells' deadly weakness.
Pellicano F, Sinclair A, Holyoake TL
Curr Hematol Malig Rep. 2011
PubMed ID: 21373837
Radioprotective effects of Bmi-1 involve epigenetic silencing of oxidase genes and enhanced DNA repair in normal human keratinocytes.
Dong Q, Oh JE, Chen W, Kim R, Kim RH, Shin KH, McBride WH, Park NH, Kang MK
J Invest Dermatol. 2011
PubMed ID: 21307872
Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring.
Xu F, Li X, Wu L, Zhang Q, Yang R, Yang Y, Zhang Z, He Q, Chang C
Ann Hematol. 2011
PubMed ID: 21125401
Impaired odontogenic differentiation of senescent dental mesenchymal stem cells is associated with loss of Bmi-1 expression.
Mehrazarin S, Oh JE, Chung CL, Chen W, Kim RH, Shi S, Park NH, Kang MK
J Endod. 2011
PubMed ID: 21496667
REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elements.
Ren X, Kerppola TK
Mol Cell Biol. 2011
PubMed ID: 21402785
BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair.
Ginjala V, Nacerddine K, Kulkarni A, Oza J, Hill SJ, Yao M, Citterio E, van Lohuizen M, Ganesan S
Mol Cell Biol. 2011
PubMed ID: 21383063
Bmi1 regulates cell fate via tumor suppressor WWOX repression in small-cell lung cancer cells.
Kimura M, Takenobu H, Akita N, Nakazawa A, Ochiai H, Shimozato O, Fujimura Y, Koseki H, Yoshino I, Kimura H, Nakagawara A, Kamijo T
Cancer Sci. 2011
PubMed ID: 21276135
BMI-1 suppresses contact inhibition and stabilizes YAP in Ewing sarcoma.
Hsu JH, Lawlor ER
Oncogene. 2011
PubMed ID: 21170084
Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells.
Juan AH, Derfoul A, Feng X, Ryall JG, Dell'Orso S, Pasut A, Zare H, Simone JM, Rudnicki MA, Sartorelli V
Genes Dev. 2011
PubMed ID: 21498568
βTrCP regulates BMI1 protein turnover via ubiquitination and degradation.
Sahasrabuddhe AA, Dimri M, Bommi PV, Dimri GP
Cell Cycle. 2011
PubMed ID: 21430439
BMI1 silencing enhances docetaxel activity and impairs antioxidant response in prostate cancer.
Crea F, Duhagon Serrat MA, Hurt EM, Thomas SB, Danesi R, Farrar WL
Int J Cancer. 2011
PubMed ID: 20568112
Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells.
Guo Y, Miyazaki M, Itoi M, Satoh R, Iwama A, Amagai T, Kawamoto H, Kanno M
Eur J Immunol. 2011
PubMed ID: 21400497
Conditional activation of Bmi1 expression regulates self-renewal, apoptosis, and differentiation of neural stem/progenitor cells in vitro and in vivo.
Yadirgi G, Leinster V, Acquati S, Bhagat H, Shakhova O, Marino S
Stem Cells. 2011
PubMed ID: 21305672
Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.
Vandamme J, Völkel P, Rosnoblet C, Le Faou P, Angrand PO
Mol Cell Proteomics. 2011
PubMed ID: 21282530
Improved outcome following allogeneic stem cell transplantation in chronic myeloid leukemia is associated with higher expression of BMI-1 and immune responses to BMI-1 protein.
Yong AS, Stephens N, Weber G, Li Y, Savani BN, Eniafe R, Keyvanfar K, Kurlander R, Rezvani K, Barrett AJ
Leukemia. 2011
PubMed ID: 21252986
An anticlastogenic function for the Polycomb Group gene Bmi1.
Chagraoui J, Hébert J, Girard S, Sauvageau G
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21402923
p16Ink4a suppression of lung adenocarcinoma by Bmi-1 in the presence of p38 activation.
Lee MO, Lee HJ, Kim MA, Kim EK, Lee JH, Heo JH, Lee SH, Cho SH, Fornace AJ, Jeong HC, Cha HJ
J Thorac Oncol. 2011
PubMed ID: 21164364
Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor.
Li L, Kwon HJ, Harada H, Ohshima H, Cho SW, Jung HS
Gene Expr Patterns. 2011
PubMed ID: 21073982
Silencing of Bmi-1 gene by RNA interference enhances sensitivity to doxorubicin in breast cancer cells.
Wu X, Liu X, Sengupta J, Bu Y, Yi F, Wang C, Shi Y, Zhu Y, Jiao Q, Song F
Indian J Exp Biol. 2011
PubMed ID: 21428211
[Regulation of lineage specification of hematopoietic stem cells by polycomb group gene Bmi1].
Oguro H
Rinsho Ketsueki. 2011
PubMed ID: 21403423
Knockdown of the Bmi-1 oncogene inhibits cell proliferation and induces cell apoptosis and is involved in the decrease of Akt phosphorylation in the human breast carcinoma cell line MCF-7.
Xu Z, Liu H, Lv X, Liu Y, Li S, Li H
Oncol Rep. 2011
PubMed ID: 21152871
Stem cell-related proteins C-KIT, C-MYC and BMI-1 in juvenile nasopharyngeal angiofibroma--do they have a role?
Renkonen S, Häyry V, Heikkilä P, Leivo I, Haglund C, Mäkitie AA, Hagström J
Virchows Arch. 2011
PubMed ID: 21113618
Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA
PLoS One. 2011
PubMed ID: 21731673
DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs.
So AY, Jung JW, Lee S, Kim HS, Kang KS
PLoS One. 2011
PubMed ID: 21572997
Overexpression of BMI-1 promotes cell growth and resistance to cisplatin treatment in osteosarcoma.
Wu Z, Min L, Chen D, Hao D, Duan Y, Qiu G, Wang Y
PLoS One. 2011
PubMed ID: 21311599
p38 MAPK-Mediated Bmi-1 down-regulation and defective proliferation in ATM-deficient neural stem cells can be restored by Akt activation.
Kim J, Hwangbo J, Wong PK
PLoS One. 2011
PubMed ID: 21305053
Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer.
Guo BH, Feng Y, Zhang R, Xu LH, Li MZ, Kung HF, Song LB, Zeng MS
Mol Cancer. 2011
PubMed ID: 21276221
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Ewing tumors that do not overexpress BMI-1 are a distinct molecular subclass with variant biology: a report from the Children's Oncology Group.
Cooper A, van Doorninck J, Ji L, Russell D, Ladanyi M, Shimada H, Krailo M, Womer RB, Hsu JH, Thomas D, Triche TJ, Sposto R, Lawlor ER
Clin Cancer Res. 2011
PubMed ID: 21047978
Fibroblast growth factor 10 represses premature cell differentiation during establishment of the intestinal progenitor niche.
Nyeng P, Bjerke MA, Norgaard GA, Qu X, Kobberup S, Jensen J
Dev Biol. 2011
PubMed ID: 20883684
Polycomb genes expression as a predictor of poor clinical outcome in children with medulloblastoma.
Zakrzewska M, Zakrzewski K, Grešner SM, Piaskowski S, Zalewska-Szewczyk B, Liberski PP
Childs Nerv Syst. 2011
PubMed ID: 20717685
Transcriptional activation of polycomb-repressed genes by ZRF1.
Richly H, Rocha-Viegas L, Ribeiro JD, Demajo S, Gundem G, Lopez-Bigas N, Nakagawa T, Rospert S, Ito T, Di Croce L
Nature. 2010
PubMed ID: 21179169
Overexpression of Bmi-1 in uterine cervical cancer: correlation with clinicopathology and prognosis.
Zhang X, Wang CX, Zhu CB, Zhang J, Kan SF, Du LT, Li W, Wang LL, Wang S
Int J Gynecol Cancer. 2010
PubMed ID: 21370603
The expression of stem cell-related indicators as a prognostic factor in human lung adenocarcinoma.
Zhang XY, Dong QG, Huang JS, Huang AM, Shi CL, Jin B, Sha HF, Feng JX, Geng Q, Zhou J, Xu HL, Han BH
J Surg Oncol. 2010
PubMed ID: 20818602
Polycomb group protein Bmi1 expression in colon cancers predicts the survival.
Du J, Li Y, Li J, Zheng J
Med Oncol. 2010
PubMed ID: 19957112
BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells.
Rizo A, Horton SJ, Olthof S, Dontje B, Ausema A, van Os R, van den Boom V, Vellenga E, de Haan G, Schuringa JJ
Blood. 2010
PubMed ID: 20724541
Increased expression of ubiquitin-specific protease 22 can promote cancer progression and predict therapy failure in human colorectal cancer.
Liu YL, Yang YM, Xu H, Dong XS
J Gastroenterol Hepatol. 2010
PubMed ID: 21039844
STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells.
Onodera A, Yamashita M, Endo Y, Kuwahara M, Tofukuji S, Hosokawa H, Kanai A, Suzuki Y, Nakayama T
J Exp Med. 2010
PubMed ID: 20956546
Identification and characterization of Bmi-1-responding element within the human p16 promoter.
Meng S, Luo M, Sun H, Yu X, Shen M, Zhang Q, Zhou R, Ju X, Tao W, Liu D, Deng H, Lu Z
J Biol Chem. 2010
PubMed ID: 20551323
BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair.
Ismail IH, Andrin C, McDonald D, Hendzel MJ
J Cell Biol. 2010
PubMed ID: 20921134
Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition.
Yang MH, Hsu DS, Wang HW, Wang HJ, Lan HY, Yang WH, Huang CH, Kao SY, Tzeng CH, Tai SK, Chang SY, Lee OK, Wu KJ
Nat Cell Biol. 2010
PubMed ID: 20818389
Bmi1 directly represses p21Waf1/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors.
Subkhankulova T, Zhang X, Leung C, Marino S
Mol Cell Neurosci. 2010
PubMed ID: 20600931
Regulation of the Polycomb protein RING1B ubiquitination by USP7.
de Bie P, Zaaroor-Regev D, Ciechanover A
Biochem Biophys Res Commun. 2010
PubMed ID: 20800574
Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex.
Pereira JD, Sansom SN, Smith J, Dobenecker MW, Tarakhovsky A, Livesey FJ
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20798045
Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.
Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A
Hepatology. 2010
PubMed ID: 20648475
Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor.
Maertens GN, El Messaoudi-Aubert S, Elderkin S, Hiom K, Peters G
EMBO J. 2010
PubMed ID: 20601937
Bmi1 distinguishes immature retinal progenitor/stem cells from the main progenitor cell population and is required for normal retinal development.
Chatoo W, Abdouh M, Duparc RH, Bernier G
Stem Cells. 2010
PubMed ID: 20549707
BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery.
Facchino S, Abdouh M, Chatoo W, Bernier G
J Neurosci. 2010
PubMed ID: 20668194
Expression of Bmi-1 gene in esophageal carcinoma cell EC9706 and its effect on cell cycle, apoptosis and migration.
Wang JF, Liu Y, Liu WJ, He SY
Chin J Cancer. 2010
PubMed ID: 20591222
The Polycomb group protein Bmi-1 is essential for the growth of multiple myeloma cells.
Jagani Z, Wiederschain D, Loo A, He D, Mosher R, Fordjour P, Monahan J, Morrissey M, Yao YM, Lengauer C, Warmuth M, Sellers WR, Dorsch M
Cancer Res. 2010
PubMed ID: 20530672
Bmi-1 is related to proliferation, survival and poor prognosis in pancreatic cancer.
Song W, Tao K, Li H, Jin C, Song Z, Li J, Shi H, Li X, Dang Z, Dou K
Cancer Sci. 2010
PubMed ID: 20426791
Role of the polycomb group gene BMI1 in normal and leukemic hematopoietic stem and progenitor cells.
Schuringa JJ, Vellenga E
Curr Opin Hematol. 2010
PubMed ID: 20308890
Expression level of Bmi-1 oncoprotein is associated with progression and prognosis in colon cancer.
Li DW, Tang HM, Fan JW, Yan DW, Zhou CZ, Li SX, Wang XL, Peng ZH
J Cancer Res Clin Oncol. 2010
PubMed ID: 20024662
Distinctive expression of the polycomb group proteins Bmi1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance.
Kikuchi J, Kinoshita I, Shimizu Y, Kikuchi E, Konishi J, Oizumi S, Kaga K, Matsuno Y, Nishimura M, Dosaka-Akita H
Cancer. 2010
PubMed ID: 20564407
Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer.
Lee KS, Lee YS, Lee JM, Ito K, Cinghu S, Kim JH, Jang JW, Li YH, Goh YM, Chi XZ, Wee H, Lee HW, Hosoya A, Chung JH, Jang JJ, Kundu JK, Surh YJ, Kim WJ, Ito Y, Jung HS, Bae SC
Oncogene. 2010
PubMed ID: 20228843
Anti-proliferation effect of BMI-1 in U937 cells with siRNA.
Zhu W, Huang L, Xu X, Qian H, Xu W
Int J Mol Med. 2010
PubMed ID: 20428793
Bmi-1 regulates self-renewal, proliferation and senescence of human fetal neural stem cells in vitro.
Wang Y, Guan Y, Wang F, Huang A, Wang S, Zhang YA
Neurosci Lett. 2010
PubMed ID: 20385206
Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T
Oncogene. 2010
PubMed ID: 20190806
Overexpression of polycomb protein BMI-1 in human specimens of breast, ovarian, endometrial and cervical cancer.
Honig A, Weidler C, Häusler S, Krockenberger M, Buchholz S, Köster F, Segerer SE, Dietl J, Engel JB
Anticancer Res. 2010
PubMed ID: 20592341
Bmi-1 reduction plays a key role in physiological and premature aging of primary human keratinocytes.
Cordisco S, Maurelli R, Bondanza S, Stefanini M, Zambruno G, Guerra L, Dellambra E
J Invest Dermatol. 2010
PubMed ID: 19907431
Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation.
Dowdy CR, Xie R, Frederick D, Hussain S, Zaidi SK, Vradii D, Javed A, Li X, Jones SN, Lian JB, van Wijnen AJ, Stein JL, Stein GS
Hum Mol Genet. 2010
PubMed ID: 20035012
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1.
Oguro H, Yuan J, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H, Nakauchi H, Iwama A
Cell Stem Cell. 2010
PubMed ID: 20207230
Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue.
Häyry V, Mäkinen LK, Atula T, Sariola H, Mäkitie A, Leivo I, Keski-Säntti H, Lundin J, Haglund C, Hagström J
Br J Cancer. 2010
PubMed ID: 20145620
The knock-down of overexpressed EZH2 and BMI-1 does not prevent osteosarcoma growth.
Sasaki H, Setoguchi T, Matsunoshita Y, Gao H, Hirotsu M, Komiya S
Oncol Rep. 2010
PubMed ID: 20127006
Bmi-1 gene is upregulated in early-stage hepatocellular carcinoma and correlates with ATP-binding cassette transporter B1 expression.
Effendi K, Mori T, Komuta M, Masugi Y, Du W, Sakamoto M
Cancer Sci. 2010
PubMed ID: 20085590
The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival.
Balasubramanian S, Adhikary G, Eckert RL
Carcinogenesis. 2010
PubMed ID: 20015867
Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice.
Zhang HW, Ding J, Jin JL, Guo J, Liu JN, Karaplis A, Goltzman D, Miao D
J Bone Miner Res. 2010
PubMed ID: 19653817
Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factor-kappaB Pathway.
Li J, Gong LY, Song LB, Jiang LL, Liu LP, Wu J, Yuan J, Cai JC, He M, Wang L, Zeng M, Cheng SY, Li M
Am J Pathol. 2010
PubMed ID: 20035051
Expression of BMI-1 and Mel-18 in breast tissue--a diagnostic marker in patients with breast cancer.
Riis ML, Lüders T, Nesbakken AJ, Vollan HS, Kristensen V, Bukholm IR
BMC Cancer. 2010
PubMed ID: 21162745
Expression and clinicopathological significance of Mel-18 and Bmi-1 mRNA in gastric carcinoma.
Lu YW, Li J, Guo WJ
J Exp Clin Cancer Res. 2010
PubMed ID: 21059209
Prognostic relevance of Bmi-1 expression and autoantibodies in esophageal squamous cell carcinoma.
Liu WL, Guo XZ, Zhang LJ, Wang JY, Zhang G, Guan S, Chen YM, Kong QL, Xu LH, Li MZ, Song LB, Zeng MS
BMC Cancer. 2010
PubMed ID: 20809956
Delta-like 4 differentially regulates murine CD4 T cell expansion via BMI1.
Schaller MA, Logue H, Mukherjee S, Lindell DM, Coelho AL, Lincoln P, Carson WF, Ito T, Cavassani KA, Chensue SW, Hogaboam CM, Lukacs NW, Kunkel SL
PLoS One. 2010
PubMed ID: 20808960
MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence.
Venkataraman S, Alimova I, Fan R, Harris P, Foreman N, Vibhakar R
PLoS One. 2010
PubMed ID: 20574517
Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain.
Yadav AK, Sahasrabuddhe AA, Dimri M, Bommi PV, Sainger R, Dimri GP
Mol Cancer. 2010
PubMed ID: 20569464
Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma.
Yang GF, He WP, Cai MY, He LR, Luo JH, Deng HX, Guan XY, Zeng MS, Zeng YX, Xie D
BMC Cancer. 2010
PubMed ID: 20377880
BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer.
Zhang XW, Sheng YP, Li Q, Qin W, Lu YW, Cheng YF, Liu BY, Zhang FC, Li J, Dimri GP, Guo WJ
Mol Cancer. 2010
PubMed ID: 20170541
Bmi1 functions as an oncogene independent of Ink4A/Arf repression in hepatic carcinogenesis.
Xu CR, Lee S, Ho C, Bommi P, Huang SA, Cheung ST, Dimri GP, Chen X
Mol Cancer Res. 2009
PubMed ID: 19934271
MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer.
Bhattacharya R, Nicoloso M, Arvizo R, Wang E, Cortez A, Rossi S, Calin GA, Mukherjee P
Cancer Res. 2009
PubMed ID: 19903841
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells.
Song LB, Li J, Liao WT, Feng Y, Yu CP, Hu LJ, Kong QL, Xu LH, Zhang X, Liu WL, Li MZ, Zhang L, Kang TB, Fu LW, Huang WL, Xia YF, Tsao SW, Li M, Band V, Band H, Shi QH, Zeng YX, Zeng MS
J Clin Invest. 2009
PubMed ID: 19884659
Polycomb group protein Bmi1 is overexpressed and essential in anchorage-independent colony formation, cell proliferation and repression of cellular senescence in cholangiocarcinoma: tissue and culture studies.
Sasaki M, Yamaguchi J, Ikeda H, Itatsu K, Nakanuma Y
Hum Pathol. 2009
PubMed ID: 19695678
Neural stem cell self-renewal requires the Mrj co-chaperone.
Watson ED, Mattar P, Schuurmans C, Cross JC
Dev Dyn. 2009
PubMed ID: 19777589
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
Markson G, Kiel C, Hyde R, Brown S, Charalabous P, Bremm A, Semple J, Woodsmith J, Duley S, Salehi-Ashtiani K, Vidal M, Komander D, Serrano L, Lehner P, Sanderson CM
Genome Res. 2009
PubMed ID: 19549727
[Association of Bmi-1 expression with clinicopathological features and prognosis of colorectal cancer].
Lin MX, Wen ZF, Feng ZY, Li ZK
Nan Fang Yi Ke Da Xue Xue Bao. 2009
PubMed ID: 19778799
Diagnostic importance of overexpression of Bmi-1 mRNA in early breast cancers.
Saeki M, Kobayashi D, Tsuji N, Kuribayashi K, Watanabe N
Int J Oncol. 2009
PubMed ID: 19639171
Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma.
Yonemitsu Y, Imazeki F, Chiba T, Fukai K, Nagai Y, Miyagi S, Arai M, Aoki R, Miyazaki M, Nakatani Y, Iwama A, Yokosuka O
Hum Pathol. 2009
PubMed ID: 19386347
Expression and distribution patterns of the stem cell marker, nestin, and the stem cell renewal factor, BMI-1, in normal human nasal mucosa and nasal polyps.
Kim TH, Lee HM, Lee SH, Choe H, Kim HK, Lee JH, Oh KH, Lee SH
Acta Otolaryngol. 2009
PubMed ID: 19012049
BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases.
Hoenerhoff MJ, Chu I, Barkan D, Liu ZY, Datta S, Dimri GP, Green JE
Oncogene. 2009
PubMed ID: 19543317
Repression of BMI1 in normal and leukemic human CD34(+) cells impairs self-renewal and induces apoptosis.
Rizo A, Olthof S, Han L, Vellenga E, de Haan G, Schuringa JJ
Blood. 2009
PubMed ID: 19556423
The polycomb group protein Bmi1 binds to the herpes simplex virus 1 latent genome and maintains repressive histone marks during latency.
Kwiatkowski DL, Thompson HW, Bloom DC
J Virol. 2009
PubMed ID: 19515780
BMI1 sustains human glioblastoma multiforme stem cell renewal.
Abdouh M, Facchino S, Chatoo W, Balasingam V, Ferreira J, Bernier G
J Neurosci. 2009
PubMed ID: 19605626
Reciprocal expression of Bmi1 and Mel-18 is associated with functioning of primitive hematopoietic cells.
Kajiume T, Ohno N, Sera Y, Kawahara Y, Yuge L, Kobayashi M
Exp Hematol. 2009
PubMed ID: 19409954
Genome-wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes.
Kallin EM, Cao R, Jothi R, Xia K, Cui K, Zhao K, Zhang Y
PLoS Genet. 2009
PubMed ID: 19503595
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche.
Ootani A, Li X, Sangiorgi E, Ho QT, Ueno H, Toda S, Sugihara H, Fujimoto K, Weissman IL, Capecchi MR, Kuo CJ
Nat Med. 2009
PubMed ID: 19398967
Association between Bmi1 and clinicopathological status of esophageal squamous cell carcinoma.
He XT, Cao XF, Ji L, Zhu B, Lv J, Wang DD, Lu PH, Cui HG
World J Gastroenterol. 2009
PubMed ID: 19452584
Bmi1 regulates mitochondrial function and the DNA damage response pathway.
Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, Ahn BH, Kumar NG, Rovira II, Xu XL, van Lohuizen M, Motoyama N, Deng CX, Finkel T
Nature. 2009
PubMed ID: 19404261
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Bmi1 deficient neural stem cells have increased integrin dependent adhesion to self-secreted matrix.
Bruggeman SW, Hulsman D, van Lohuizen M
Biochim Biophys Acta. 2009
PubMed ID: 19298843
Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis.
Sangiorgi E, Capecchi MR
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19372370
Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo.
He S, Iwashita T, Buchstaller J, Molofsky AV, Thomas D, Morrison SJ
Dev Biol. 2009
PubMed ID: 19389366
[Effect of silencing bmi-1 by RNA interference on function of K562 cell line].
Chen XL, Ren Q, Chen ZP, Zhou ZP, Zhao QJ, Qiu ZY, Dong CL, Han ZC
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009
PubMed ID: 19379548
Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses.
Chan JA, Balasubramanian S, Witt RM, Nazemi KJ, Choi Y, Pazyra-Murphy MF, Walsh CO, Thompson M, Segal RA
Nat Neurosci. 2009
PubMed ID: 19287388
Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory.
Nakayama T, Yamashita M
Semin Immunol. 2009
PubMed ID: 19269851
BMI-1 expression is enhanced through transcriptional and posttranscriptional regulation during the progression of chronic myeloid leukemia.
Bhattacharyya J, Mihara K, Yasunaga S, Tanaka H, Hoshi M, Takihara Y, Kimura A
Ann Hematol. 2009
PubMed ID: 18781299
Identification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitin-proteasome system.
Zhang J, Sarge KD
FEBS Lett. 2009
PubMed ID: 19233177
Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain.
Fasano CA, Phoenix TN, Kokovay E, Lowry N, Elkabetz Y, Dimos JT, Lemischka IR, Studer L, Temple S
Genes Dev. 2009
PubMed ID: 19270157
The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity.
Chatoo W, Abdouh M, David J, Champagne MP, Ferreira J, Rodier F, Bernier G
J Neurosci. 2009
PubMed ID: 19144853
The E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex - a potentially new drug target.
Alchanati I, Teicher C, Cohen G, Shemesh V, Barr HM, Nakache P, Ben-Avraham D, Idelevich A, Angel I, Livnah N, Tuvia S, Reiss Y, Taglicht D, Erez O
PLoS One. 2009
PubMed ID: 19956605
Isolation and characterization of spheroid cells from human malignant melanoma cell line WM-266-4.
Na YR, Seok SH, Kim DJ, Han JH, Kim TH, Jung H, Lee BH, Park JH
Tumour Biol. 2009
PubMed ID: 19940551
PTEN inhibits BMI1 function independently of its phosphatase activity.
Fan C, He L, Kapoor A, Rybak AP, De Melo J, Cutz JC, Tang D
Mol Cancer. 2009
PubMed ID: 19903340
Knockdown of Bmi-1 impairs growth and invasiveness of human gastric carcinoma cells.
Xiao J, Deng C
Oncol Res. 2009
PubMed ID: 19806792
Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.
Maertens GN, El Messaoudi-Aubert S, Racek T, Stock JK, Nicholls J, Rodriguez-Niedenführ M, Gil J, Peters G
PLoS One. 2009
PubMed ID: 19636380
Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence.
Agherbi H, Gaussmann-Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M
PLoS One. 2009
PubMed ID: 19462008
The synovial sarcoma-associated SYT-SSX2 oncogene antagonizes the polycomb complex protein Bmi1.
Barco R, Garcia CB, Eid JE
PLoS One. 2009
PubMed ID: 19337376
Expression of Bmi-1 is a prognostic marker in bladder cancer.
Qin ZK, Yang JA, Ye YL, Zhang X, Xu LH, Zhou FJ, Han H, Liu ZW, Song LB, Zeng MS
BMC Cancer. 2009
PubMed ID: 19228380
Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer.
Becker M, Korn C, Sienerth AR, Voswinckel R, Luetkenhaus K, Ceteci F, Rapp UR
PLoS One. 2009
PubMed ID: 19156217
Oncoprotein BMI-1 induces the malignant transformation of HaCaT cells.
Wang Q, Li WL, You P, Su J, Zhu MH, Xie DF, Zhu HY, He ZY, Li JX, Ding XY, Wang X, Hu YP
J Cell Biochem. 2009
PubMed ID: 19021148
Expression of Bmi-1 protein in tumor tissues is associated with favorable prognosis in breast cancer patients.
Choi YJ, Choi YL, Cho EY, Shin YK, Sung KW, Hwang YK, Lee SJ, Kong G, Lee JE, Kim JS, Kim JH, Yang JH, Nam SJ
Breast Cancer Res Treat. 2009
PubMed ID: 18228133
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
[Expression of SALL4 and BMI-1 mRNA in acute leukemia].
Tang P, Sun H, Liu YF, Wang GY, Yin YF
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008
PubMed ID: 19099625
[Expression and clinical significance of Bmi-1 protein in bladder cancer]
Qin ZK, Yang JA, Zeng MS, Zhou FJ, Han H, Liu ZW, Yu SL, Li YH, Chen ZF
Ai Zheng. 2008
PubMed ID: 19080003
[Expression and significance of Bmi-1 and Ki67 in colorectal carcinoma tissues]
Lin MX, Wen ZF, Feng ZY, He D
Ai Zheng. 2008
PubMed ID: 19080002
Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion.
Michael LE, Westerman BA, Ermilov AN, Wang A, Ferris J, Liu J, Blom M, Ellison DW, van Lohuizen M, Dlugosz AA
Neoplasia. 2008
PubMed ID: 19048113
Characteristic overexpression of the forkhead box transcription factor Foxf1 in Patched-associated tumors.
Wendling DS, Lück C, von Schweinitz D, Kappler R
Int J Mol Med. 2008
PubMed ID: 19020777
Bmi1 promotes prostate tumorigenesis via inhibiting p16(INK4A) and p14(ARF) expression.
Fan C, He L, Kapoor A, Gillis A, Rybak AP, Cutz JC, Tang D
Biochim Biophys Acta. 2008
PubMed ID: 18817867
HOX expression patterns identify a common signature for favorable AML.
Andreeff M, Ruvolo V, Gadgil S, Zeng C, Coombes K, Chen W, Kornblau S, Barón AE, Drabkin HA
Leukemia. 2008
PubMed ID: 18668134
Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression.
Nishino J, Kim I, Chada K, Morrison SJ
Cell. 2008
PubMed ID: 18957199
The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma.
Chiba T, Miyagi S, Saraya A, Aoki R, Seki A, Morita Y, Yonemitsu Y, Yokosuka O, Taniguchi H, Nakauchi H, Iwama A
Cancer Res. 2008
PubMed ID: 18829528
Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours.
Häyry V, Tynninen O, Haapasalo HK, Wölfer J, Paulus W, Hasselblatt M, Sariola H, Paetau A, Sarna S, Niemelä M, Wartiovaara K, Nupponen NN
Neuropathol Appl Neurobiol. 2008
PubMed ID: 18346113
Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome.
Capellini TD, Zewdu R, Di Giacomo G, Asciutti S, Kugler JE, Di Gregorio A, Selleri L
Dev Biol. 2008
PubMed ID: 18691704
Association between BMI-1 expression, acute graft-versus-host disease, and outcome following allogeneic stem cell transplantation from HLA-identical siblings in chronic myeloid leukemia.
Mohty M, Szydlo RM, Yong AS, Apperley JF, Goldman JM, Melo JV
Blood. 2008
PubMed ID: 18565849
Prognostic value of Bmi-1 oncoprotein expression in NSCLC patients: a tissue microarray study.
Vrzalikova K, Skarda J, Ehrmann J, Murray PG, Fridman E, Kopolovic J, Knizetova P, Hajduch M, Klein J, Kolek V, Radova L, Kolar Z
J Cancer Res Clin Oncol. 2008
PubMed ID: 18264721
Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion.
Dovey JS, Zacharek SJ, Kim CF, Lees JA
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18697930
BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression.
Douglas D, Hsu JH, Hung L, Cooper A, Abdueva D, van Doorninck J, Peng G, Shimada H, Triche TJ, Lawlor ER
Cancer Res. 2008
PubMed ID: 18701473
The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma.
Sasaki M, Ikeda H, Itatsu K, Yamaguchi J, Sawada S, Minato H, Ohta T, Nakanuma Y
Lab Invest. 2008
PubMed ID: 18591938
Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium.
Pietersen AM, Evers B, Prasad AA, Tanger E, Cornelissen-Steijger P, Jonkers J, van Lohuizen M
Curr Biol. 2008
PubMed ID: 18635350
Polycomb group protein-associated chromatin is reproduced in post-mitotic G1 phase and is required for S phase progression.
Aoto T, Saitoh N, Sakamoto Y, Watanabe S, Nakao M
J Biol Chem. 2008
PubMed ID: 18453536
Bmi1 is expressed in vivo in intestinal stem cells.
Sangiorgi E, Capecchi MR
Nat Genet. 2008
PubMed ID: 18536716
Copy number alterations of the polycomb gene BMI1 in gliomas.
Häyry V, Tanner M, Blom T, Tynninen O, Roselli A, Ollikainen M, Sariola H, Wartiovaara K, Nupponen NN
Acta Neuropathol. 2008
PubMed ID: 18427816
Induction of neural stem cell-like cells (NSCLCs) from mouse astrocytes by Bmi1.
Moon JH, Yoon BS, Kim B, Park G, Jung HY, Maeng I, Jun EK, Yoo SJ, Kim A, Oh S, Whang KY, Kim H, Kim DW, Kim KD, You S
Biochem Biophys Res Commun. 2008
PubMed ID: 18439910
FoxM1c counteracts oxidative stress-induced senescence and stimulates Bmi-1 expression.
Li SK, Smith DK, Leung WY, Cheung AM, Lam EW, Dimri GP, Yao KM
J Biol Chem. 2008
PubMed ID: 18408007
Expression localization of Bmi1 in mice testis.
Zhang S, Li D, Li E, Li L, Wang J, Wang C, Lu J, Zhang X
Mol Cell Endocrinol. 2008
PubMed ID: 18359150
BMI1 as oncogenic candidate in a novel TCRB-associated chromosomal aberration in a patient with TCRgammadelta+ T-cell acute lymphoblastic leukemia.
Larmonie NS, Dik WA, Beverloo HB, van Wering ER, van Dongen JJ, Langerak AW
Leukemia. 2008
PubMed ID: 17989714
Low BMI-1 expression is associated with an activated BMI-1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma.
Engelsen IB, Mannelqvist M, Stefansson IM, Carter SL, Beroukhim R, Øyan AM, Otte AP, Kalland KH, Akslen LA, Salvesen HB
Br J Cancer. 2008
PubMed ID: 18475299
Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene.
Yamashita M, Kuwahara M, Suzuki A, Hirahara K, Shinnaksu R, Hosokawa H, Hasegawa A, Motohashi S, Iwama A, Nakayama T
J Exp Med. 2008
PubMed ID: 18411339
E2f6 and Bmi1 cooperate in axial skeletal development.
Courel M, Friesenhahn L, Lees JA
Dev Dyn. 2008
PubMed ID: 18366140
Loss of BMI-1 expression is associated with clinical progress of malignant melanoma.
Bachmann IM, Puntervoll HE, Otte AP, Akslen LA
Mod Pathol. 2008
PubMed ID: 18246051
Increased polycomb-group oncogene Bmi-1 expression correlates with poor prognosis in hepatocellular carcinoma.
Wang H, Pan K, Zhang HK, Weng DS, Zhou J, Li JJ, Huang W, Song HF, Chen MS, Xia JC
J Cancer Res Clin Oncol. 2008
PubMed ID: 17917742
PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.
Puschendorf M, Terranova R, Boutsma E, Mao X, Isono K, Brykczynska U, Kolb C, Otte AP, Koseki H, Orkin SH, van Lohuizen M, Peters AH
Nat Genet. 2008
PubMed ID: 18311137
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Correlations of BMI-1 expression and telomerase activity in ovarian cancer tissues.
Zhang F, Sui L, Xin T
Exp Oncol. 2008
PubMed ID: 18438345
BMI-1 expression is inversely correlated with the grading of renal clear cell carcinoma.
Kozakowski N, Soleiman A, Pammer J
Pathol Oncol Res. 2008
PubMed ID: 18347933
Long-term maintenance of human hematopoietic stem/progenitor cells by expression of BMI1.
Rizo A, Dontje B, Vellenga E, de Haan G, Schuringa JJ
Blood. 2008
PubMed ID: 18156489
BMI-1 autoantibody in serum as a new potential biomarker of nasopharyngeal carcinoma.
Tong YQ, Liu B, Huang J, Liu Y, Guo FJ, Zhou GH, Xie PL, Li YH, Hu JY, Li GC
Cancer Biol Ther. 2008
PubMed ID: 18094618
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Thymocyte proliferation induced by pre-T cell receptor signaling is maintained through polycomb gene product Bmi-1-mediated Cdkn2a repression.
Miyazaki M, Miyazaki K, Itoi M, Katoh Y, Guo Y, Kanno R, Katoh-Fukui Y, Honda H, Amagai T, van Lohuizen M, Kawamoto H, Kanno M
Immunity. 2008
PubMed ID: 18275833
Independent prognostic value of the basal-like phenotype of breast cancer and associations with EGFR and candidate stem cell marker BMI-1.
Arnes JB, Collett K, Akslen LA
Histopathology. 2008
PubMed ID: 18269588
Complementary and independent function for Hoxb4 and Bmi1 in HSC activity.
Faubert A, Chagraoui J, Mayotte N, Fréchette M, Iscove NN, Humphries RK, Sauvageau G
Cold Spring Harb Symp Quant Biol. 2008
PubMed ID: 19022763
Overexpression of BMI1, a polycomb group repressor protein, in bladder tumors: a preliminary report.
Shafaroudi AM, Mowla SJ, Ziaee SA, Bahrami AR, Atlasi Y, Malakootian M
Urol J. 2008
PubMed ID: 18592462
Expression of the Polycomb-Group protein BMI1 and correlation with p16 in astrocytomas an immunohistochemical study on 80 cases.
Tirabosco R, De Maglio G, Skrap M, Falconieri G, Pizzolitto S
Pathol Res Pract. 2008
PubMed ID: 18450386
Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction.
Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI
Gene Expr Patterns. 2008
PubMed ID: 18023262
Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis.
Lee K, Adhikary G, Balasubramanian S, Gopalakrishnan R, McCormick T, Dimri GP, Eckert RL, Rorke EA
J Invest Dermatol. 2008
PubMed ID: 17625597
Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways.
Datta S, Hoenerhoff MJ, Bommi P, Sainger R, Guo WJ, Dimri M, Band H, Band V, Green JE, Dimri GP
Cancer Res. 2007
PubMed ID: 17974970
Consistent expression of the stem cell renewal factor BMI-1 in primary and metastatic melanoma.
Mihic-Probst D, Kuster A, Kilgus S, Bode-Lesniewska B, Ingold-Heppner B, Leung C, Storz M, Seifert B, Marino S, Schraml P, Dummer R, Moch H
Int J Cancer. 2007
PubMed ID: 17597110
Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma.
Bruggeman SW, Hulsman D, Tanger E, Buckle T, Blom M, Zevenhoven J, van Tellingen O, van Lohuizen M
Cancer Cell. 2007
PubMed ID: 17936558
Lsh controls Hox gene silencing during development.
Xi S, Zhu H, Xu H, Schmidtmann A, Geiman TM, Muegge K
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17726103
Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.
Chiba T, Zheng YW, Kita K, Yokosuka O, Saisho H, Onodera M, Miyoshi H, Nakano M, Zen Y, Nakanuma Y, Nakauchi H, Iwama A, Taniguchi H
Gastroenterology. 2007
PubMed ID: 17673212
Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte.
Heffner M, Fearon DT
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17686974
Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features.
van Leenders GJ, Dukers D, Hessels D, van den Kieboom SW, Hulsbergen CA, Witjes JA, Otte AP, Meijer CJ, Raaphorst FM
Eur Urol. 2007
PubMed ID: 17134822
[Association of Bmi-1 mRNA expression with differentiation, metastasis and prognosis of gastric carcinoma]
Huang KH, Liu JH, Li XX, Song LB, Zeng MS
Nan Fang Yi Ke Da Xue Xue Bao. 2007
PubMed ID: 17666329
Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis.
Wiederschain D, Chen L, Johnson B, Bettano K, Jackson D, Taraszka J, Wang YK, Jones MD, Morrissey M, Deeds J, Mosher R, Fordjour P, Lengauer C, Benson JD
Mol Cell Biol. 2007
PubMed ID: 17452456
Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells.
Hosen N, Yamane T, Muijtjens M, Pham K, Clarke MF, Weissman IL
Stem Cells. 2007
PubMed ID: 17395774
The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia.
Mohty M, Yong AS, Szydlo RM, Apperley JF, Melo JV
Blood. 2007
PubMed ID: 17360938
Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells.
Yang J, Chai L, Liu F, Fink LM, Lin P, Silberstein LE, Amin HM, Ward DC, Ma Y
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17557835
shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development.
Fasano CA, Dimos JT, Ivanova NB, Lowry N, Lemischka IR, Temple S
Cell Stem Cell. 2007
PubMed ID: 18371338
Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells.
Guo WJ, Zeng MS, Yadav A, Song LB, Guo BH, Band V, Dimri GP
Cancer Res. 2007
PubMed ID: 17545584
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms.
Ruas M, Gregory F, Jones R, Poolman R, Starborg M, Rowe J, Brookes S, Peters G
Mol Cell Biol. 2007
PubMed ID: 17420273
Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor.
Sánchez C, Sánchez I, Demmers JA, Rodriguez P, Strouboulis J, Vidal M
Mol Cell Proteomics. 2007
PubMed ID: 17296600
Bmi-1 over-expression plays a secondary role in chronic myeloid leukemia transformation.
Merkerova M, Bruchova H, Kracmarova A, Klamova H, Brdicka R
Leuk Lymphoma. 2007
PubMed ID: 17454639
Comprehensive analysis of homeobox genes in Hodgkin lymphoma cell lines identifies dysregulated expression of HOXB9 mediated via ERK5 signaling and BMI1.
Nagel S, Burek C, Venturini L, Scherr M, Quentmeier H, Meyer C, Rosenwald A, Drexler HG, MacLeod RA
Blood. 2007
PubMed ID: 17148583
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.
Dietrich N, Bracken AP, Trinh E, Schjerling CK, Koseki H, Rappsilber J, Helin K, Hansen KH
EMBO J. 2007
PubMed ID: 17332741
Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells.
Dutton A, Woodman CB, Chukwuma MB, Last JI, Wei W, Vockerodt M, Baumforth KR, Flavell JR, Rowe M, Taylor AM, Young LS, Murray PG
Blood. 2007
PubMed ID: 17148591
PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors.
Deshpande AM, Akunowicz JD, Reveles XT, Patel BB, Saria EA, Gorlick RG, Naylor SL, Leach RJ, Hansen MF
Oncogene. 2007
PubMed ID: 17001316
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.
Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Mönch K, Minucci S, Porse BT, Marine JC, Hansen KH, Helin K
Genes Dev. 2007
PubMed ID: 17344414
Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing.
Negishi M, Saraya A, Miyagi S, Nagao K, Inagaki Y, Nishikawa M, Tajima S, Koseki H, Tsuda H, Takasaki Y, Nakauchi H, Iwama A
Biochem Biophys Res Commun. 2007
PubMed ID: 17214966
[Expression and significance of Bmi-1 in breast cancer]
Feng Y, Song LB, Guo BH, Liao WT, Li MZ, Liu WL, Zeng MS, Zhang L
Ai Zheng. 2007
PubMed ID: 17298744
Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT.
Haga K, Ohno S, Yugawa T, Narisawa-Saito M, Fujita M, Sakamoto M, Galloway DA, Kiyono T
Cancer Sci. 2007
PubMed ID: 17233832
Bmi-1 cooperates with human papillomavirus type 16 E6 to immortalize normal human oral keratinocytes.
Kim RH, Kang MK, Shin KH, Oo ZM, Han T, Baluda MA, Park NH
Exp Cell Res. 2007
PubMed ID: 17161394
Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins.
Guo WJ, Datta S, Band V, Dimri GP
Mol Biol Cell. 2007
PubMed ID: 17151361
Elevated Bmi-1 expression is associated with dysplastic cell transformation during oral carcinogenesis and is required for cancer cell replication and survival.
Kang MK, Kim RH, Kim SJ, Yip FK, Shin KH, Dimri GP, Christensen R, Han T, Park NH
Br J Cancer. 2007
PubMed ID: 17179983
Circulating Bmi-1 mRNA as a possible prognostic factor for advanced breast cancer patients.
Silva J, García V, García JM, Peña C, Domínguez G, Díaz R, Lorenzo Y, Hurtado A, Sánchez A, Bonilla F
Breast Cancer Res. 2007
PubMed ID: 17711569
The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity.
Ben-Saadon R, Zaaroor D, Ziv T, Ciechanover A
Mol Cell. 2006
PubMed ID: 17157253
Dysregulated expression of stem cell factor Bmi1 in precancerous lesions of the gastrointestinal tract.
Tateishi K, Ohta M, Kanai F, Guleng B, Tanaka Y, Asaoka Y, Tada M, Seto M, Jazag A, Lianjie L, Okamoto M, Isayama H, Tada M, Yoshida H, Kawabe T, Omata M
Clin Cancer Res. 2006
PubMed ID: 17145814
Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas.
Silva J, García JM, Peña C, García V, Domínguez G, Suárez D, Camacho FI, Espinosa R, Provencio M, España P, Bonilla F
Clin Cancer Res. 2006
PubMed ID: 17145810
Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3.
Hosokawa H, Kimura MY, Shinnakasu R, Suzuki A, Miki T, Koseki H, van Lohuizen M, Yamashita M, Nakayama T
J Immunol. 2006
PubMed ID: 17114435
Juxtaposed Polycomb complexes co-regulate vertebral identity.
Kim SY, Paylor SW, Magnuson T, Schumacher A
Development. 2006
PubMed ID: 17107999
Bmi-1 regulates the differentiation and clonogenic self-renewal of I-type neuroblastoma cells in a concentration-dependent manner.
Cui H, Ma J, Ding J, Li T, Alam G, Ding HF
J Biol Chem. 2006
PubMed ID: 16982619
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
BMI-1: a protein expressed in stem cells, specialized cells and tumors of the gastrointestinal tract.
Reinisch C, Kandutsch S, Uthman A, Pammer J
Histol Histopathol. 2006
PubMed ID: 16874656
Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice.
Oguro H, Iwama A, Morita Y, Kamijo T, van Lohuizen M, Nakauchi H
J Exp Med. 2006
PubMed ID: 16954369
Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis.
Sasaki M, Ikeda H, Sato Y, Nakanuma Y
Am J Pathol. 2006
PubMed ID: 16936260
Differential expression of polycomb repression complex 1 (PRC1) members in the developing mouse brain reveals multiple complexes.
Vogel T, Stoykova A, Gruss P
Dev Dyn. 2006
PubMed ID: 16786585
Role of Bmi1 in H2A ubiquitylation and Hox gene silencing.
Wei J, Zhai L, Xu J, Wang H
J Biol Chem. 2006
PubMed ID: 16751658
Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer.
Berezovska OP, Glinskii AB, Yang Z, Li XM, Hoffman RM, Glinsky GV
Cell Cycle. 2006
PubMed ID: 16963837
E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.
Chagraoui J, Niessen SL, Lessard J, Girard S, Coulombe P, Sauvageau M, Meloche S, Sauvageau G
Genes Dev. 2006
PubMed ID: 16882984
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex.
Li Z, Cao R, Wang M, Myers MP, Zhang Y, Xu RM
J Biol Chem. 2006
PubMed ID: 16714294
Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death.
Liu L, Andrews LG, Tollefsbol TO
Oncogene. 2006
PubMed ID: 16501599
Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b.
Buchwald G, van der Stoop P, Weichenrieder O, Perrakis A, van Lohuizen M, Sixma TK
EMBO J. 2006
PubMed ID: 16710298
Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8.
Fujimura Y, Isono K, Vidal M, Endoh M, Kajita H, Mizutani-Koseki Y, Takihara Y, van Lohuizen M, Otte A, Jenuwein T, Deschamps J, Koseki H
Development. 2006
PubMed ID: 16687444
[Cloning of Bmi1 cDNA from mouse testis and its expression in E. coli BL21]
Zhang SQ, Li DX, Li EZ, Wang CY, Zhang XM, Lu JY
Zhonghua Nan Ke Xue. 2006
PubMed ID: 16683560
Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A.
Lorente M, Pérez C, Sánchez C, Donohoe M, Shi Y, Vidal M
Mech Dev. 2006
PubMed ID: 16624538
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).
Guney I, Wu S, Sedivy JM
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16537449
BMI1 loss delays photoreceptor degeneration in Rd1 mice. Bmi1 loss and neuroprotection in Rd1 mice.
Zencak D, Crippa SV, Tekaya M, Tanger E, Schorderet DE, Munier FL, van Lohuizen M, Arsenijevic Y
Adv Exp Med Biol. 2006
PubMed ID: 17249577
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.
Cao R, Tsukada Y, Zhang Y
Mol Cell. 2005
PubMed ID: 16359901
Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1.
Hernández-Muñoz I, Taghavi P, Kuijl C, Neefjes J, van Lohuizen M
Mol Cell Biol. 2005
PubMed ID: 16314526
CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes.
Dik WA, Brahim W, Braun C, Asnafi V, Dastugue N, Bernard OA, van Dongen JJ, Langerak AW, Macintyre EA, Delabesse E
Leukemia. 2005
PubMed ID: 16107895
A human protein-protein interaction network: a resource for annotating the proteome.
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Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
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Science. 2005
PubMed ID: 16141072
Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.
Bulfone A, Carotenuto P, Faedo A, Aglio V, Garzia L, Bello AM, Basile A, Andrè A, Cocchia M, Guardiola O, Ballabio A, Rubenstein JL, Zollo M
J Neurosci. 2005
PubMed ID: 16107646
BMI-1 is highly expressed in M0-subtype acute myeloid leukemia.
Sawa M, Yamamoto K, Yokozawa T, Kiyoi H, Hishida A, Kajiguchi T, Seto M, Kohno A, Kitamura K, Itoh Y, Asou N, Hamajima N, Emi N, Naoe T
Int J Hematol. 2005
PubMed ID: 16105758
Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.
Bruggeman SW, Valk-Lingbeek ME, van der Stoop PP, Jacobs JJ, Kieboom K, Tanger E, Hulsman D, Leung C, Arsenijevic Y, Marino S, van Lohuizen M
Genes Dev. 2005
PubMed ID: 15964995
Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.
Molofsky AV, He S, Bydon M, Morrison SJ, Pardal R
Genes Dev. 2005
PubMed ID: 15964994
Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation.
Zencak D, Lingbeek M, Kostic C, Tekaya M, Tanger E, Hornfeld D, Jaquet M, Munier FL, Schorderet DF, van Lohuizen M, Arsenijevic Y
J Neurosci. 2005
PubMed ID: 15958744
Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.
Glinsky GV, Berezovska O, Glinskii AB
J Clin Invest. 2005
PubMed ID: 15931389
Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase.
Hernández-Muñoz I, Lund AH, van der Stoop P, Boutsma E, Muijrers I, Verhoeven E, Nusinow DA, Panning B, Marahrens Y, van Lohuizen M
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15897469
MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1.
Voncken JW, Niessen H, Neufeld B, Rennefahrt U, Dahlmans V, Kubben N, Holzer B, Ludwig S, Rapp UR
J Biol Chem. 2005
PubMed ID: 15563468
Polycomb gene product Bmi-1 regulates stem cell self-renewal.
Nakauchi H, Oguro H, Negishi M, Iwama A
Ernst Schering Res Found Workshop. 2005
PubMed ID: 16080288
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1.
Iwama A, Oguro H, Negishi M, Kato Y, Morita Y, Tsukui H, Ema H, Kamijo T, Katoh-Fukui Y, Koseki H, van Lohuizen M, Nakauchi H
Immunity. 2004
PubMed ID: 15589172
Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells.
MacGrogan D, Kalakonda N, Alvarez S, Scandura JM, Boccuni P, Johansson B, Nimer SD
Genes Chromosomes Cancer. 2004
PubMed ID: 15334543
Role of histone H2A ubiquitination in Polycomb silencing.
Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, Zhang Y
Nature. 2004
PubMed ID: 15386022
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Age-associated alteration of gene expression patterns in mouse oocytes.
Hamatani T, Falco G, Carter MG, Akutsu H, Stagg CA, Sharov AA, Dudekula DB, VanBuren V, Ko MS
Hum Mol Genet. 2004
PubMed ID: 15317747
The DNA sequence and comparative analysis of human chromosome 10.
Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J
Nature. 2004
PubMed ID: 15164054
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG.
Sun LQ, Lee DW, Zhang Q, Xiao W, Raabe EH, Meeker A, Miao D, Huso DL, Arceci RJ
Genes Dev. 2004
PubMed ID: 15105378
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas.
Leung C, Lingbeek M, Shakhova O, Liu J, Tanger E, Saremaslani P, Van Lohuizen M, Marino S
Nature. 2004
PubMed ID: 15029199
Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development.
Kalinichenko VV, Gusarova GA, Kim IM, Shin B, Yoder HM, Clark J, Sapozhnikov AM, Whitsett JA, Costa RH
Am J Physiol Lung Cell Mol Physiol. 2004
PubMed ID: 14607778
Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.
Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K
Genes Cells. 2004
PubMed ID: 15009096
The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins.
Kim JH, Yoon SY, Kim CN, Joo JH, Moon SK, Choe IS, Choe YK, Kim JW
Cancer Lett. 2004
PubMed ID: 14732230
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF.
Kranc KR, Bamforth SD, Bragança J, Norbury C, van Lohuizen M, Bhattacharya S
Mol Cell Biol. 2003
PubMed ID: 14560011
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation.
Molofsky AV, Pardal R, Iwashita T, Park IK, Clarke MF, Morrison SJ
Nature. 2003
PubMed ID: 14574365
Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1.
Smith KS, Chanda SK, Lingbeek M, Ross DT, Botstein D, van Lohuizen M, Cleary ML
Mol Cell. 2003
PubMed ID: 14536079
MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein.
Xia ZB, Anderson M, Diaz MO, Zeleznik-Le NJ
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12829790
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ, Clarke MF
Nature. 2003
PubMed ID: 12714971
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Lessard J, Sauvageau G
Nature. 2003
PubMed ID: 12714970
Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition.
Voncken JW, Roelen BA, Roefs M, de Vries S, Verhoeven E, Marino S, Deschamps J, van Lohuizen M
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12589020
Polycomb group gene silencing proteins are concentrated in the perichromatin compartment of the mammalian nucleus.
Cmarko D, Verschure PJ, Otte AP, van Driel R, Fakan S
J Cell Sci. 2003
PubMed ID: 12482919
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1.
Itahana K, Zou Y, Itahana Y, Martinez JL, Beausejour C, Jacobs JJ, Van Lohuizen M, Band V, Campisi J, Dimri GP
Mol Cell Biol. 2003
PubMed ID: 12482990
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling.
Barna M, Merghoub T, Costoya JA, Ruggero D, Branford M, Bergia A, Samori B, Pandolfi PP
Dev Cell. 2002
PubMed ID: 12408802
Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice.
Suzuki M, Mizutani-Koseki Y, Fujimura Y, Miyagishima H, Kaneko T, Takada Y, Akasaka T, Tanzawa H, Takihara Y, Nakano M, Masumoto H, Vidal M, Isono K, Koseki H
Development. 2002
PubMed ID: 12183370
The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.
Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE
Mol Cell Biol. 2002
PubMed ID: 12167701
The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells.
Dimri GP, Martinez JL, Jacobs JJ, Keblusek P, Itahana K, Van Lohuizen M, Campisi J, Wazer DE, Band V
Cancer Res. 2002
PubMed ID: 12183433
Overexpression of Polycomb-group gene rae28 in cardiomyocytes does not complement abnormal cardiac morphogenesis in mice lacking rae28 but causes dilated cardiomyopathy.
Koga H, Kaji Y, Nishii K, Shirai M, Tomotsune D, Osugi T, Sawada A, Kim JY, Hara J, Miwa T, Yamauchi-Takihara K, Shibata Y, Takihara Y
Lab Invest. 2002
PubMed ID: 11950896
Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression.
Akasaka T, van Lohuizen M, van der Lugt N, Mizutani-Koseki Y, Kanno M, Taniguchi M, Vidal M, Alkema M, Berns A, Koseki H
Development. 2001
PubMed ID: 11290297
The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex.
Trimarchi JM, Fairchild B, Wen J, Lees JA
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11171983
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties.
Bárdos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS
J Biol Chem. 2000
PubMed ID: 10825164
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10737800
Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development.
Hanson RD, Hess JL, Yu BD, Ernst P, van Lohuizen M, Berns A, van der Lugt NM, Shashikant CS, Ruddle FH, Seto M, Korsmeyer SJ
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10588712
Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status.
Voncken JW, Schweizer D, Aagaard L, Sattler L, Jantsch MF, van Lohuizen M
J Cell Sci. 1999
PubMed ID: 10574711
Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation.
Lessard J, Schumacher A, Thorsteinsdottir U, van Lohuizen M, Magnuson T, Sauvageau G
Genes Dev. 1999
PubMed ID: 10541555
Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.
Jacobs JJ, Scheijen B, Voncken JW, Kieboom K, Berns A, van Lohuizen M
Genes Dev. 1999
PubMed ID: 10541554
A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes.
Koga H, Matsui S, Hirota T, Takebayashi S, Okumura K, Saya H
Oncogene. 1999
PubMed ID: 10445843
Identification and characterization of collaborating oncogenes in compound mutant mice.
Berns A, Mikkers H, Krimpenfort P, Allen J, Scheijen B, Jonkers J
Cancer Res. 1999
PubMed ID: 10197595
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.
Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M
Nature. 1999
PubMed ID: 9923679
RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity.
Satijn DP, Otte AP
Mol Cell Biol. 1999
PubMed ID: 9858531
Nucleotide sequence of the feline Bmi-1 coding region.
Kinnon S, Fulton R
DNA Seq. 1999
PubMed ID: 10727088
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Genetic interactions and dosage effects of Polycomb group genes in mice.
Bel S, Coré N, Djabali M, Kieboom K, Van der Lugt N, Alkema MJ, Van Lohuizen M
Development. 1998
PubMed ID: 9716520
The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of RING finger domains.
Hemenway CS, Halligan BW, Levy LS
Oncogene. 1998
PubMed ID: 9627119
RAE28, BMI1, and M33 are members of heterogeneous multimeric mammalian Polycomb group complexes.
Hashimoto N, Brock HW, Nomura M, Kyba M, Hodgson J, Fujita Y, Takihara Y, Shimada K, Higashinakagawa T
Biochem Biophys Res Commun. 1998
PubMed ID: 9571155
Functional analysis of mouse Polycomb group genes.
van Lohuizen M
Cell Mol Life Sci. 1998
PubMed ID: 9487388
MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex.
Alkema MJ, Jacobs J, Voncken JW, Jenkins NA, Copeland NG, Satijn DP, Otte AP, Berns A, van Lohuizen M
J Mol Biol. 1997
PubMed ID: 9367786
Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain.
Schoorlemmer J, Marcos-Gutiérrez C, Were F, Martínez R, García E, Satijn DP, Otte AP, Vidal M
EMBO J. 1997
PubMed ID: 9312051
RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.
Satijn DP, Gunster MJ, van der Vlag J, Hamer KM, Schul W, Alkema MJ, Saurin AJ, Freemont PS, van Driel R, Otte AP
Mol Cell Biol. 1997
PubMed ID: 9199346
Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond.
Schumacher A, Magnuson T
Trends Genet. 1997
PubMed ID: 9153995
Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.
Gunster MJ, Satijn DP, Hamer KM, den Blaauwen JL, de Bruijn D, Alkema MJ, van Lohuizen M, van Driel R, Otte AP
Mol Cell Biol. 1997
PubMed ID: 9121482
Mapping in the region of Danforth's short tail and the localization of tail length modifiers.
Alfred JB, Rance K, Taylor BA, Phillips SJ, Abbott CM, Jackson IJ
Genome Res. 1997
PubMed ID: 9049629
Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex.
Alkema MJ, Bronk M, Verhoeven E, Otte A, van 't Veer LJ, Berns A, van Lohuizen M
Genes Dev. 1997
PubMed ID: 9009205
Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice.
Scheijen B, Jonkers J, Acton D, Berns A
J Virol. 1997
PubMed ID: 8985317
Transformation by the Bmi-1 oncoprotein correlates with its subnuclear localization but not its transcriptional suppression activity.
Cohen KJ, Hanna JS, Prescott JE, Dang CV
Mol Cell Biol. 1996
PubMed ID: 8816465
The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression.
van der Lugt NM, Alkema M, Berns A, Deschamps J
Mech Dev. 1996
PubMed ID: 8887324
Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene.
Chiang PW, Wang SQ, Smithivas P, Song WJ, Crombez E, Akhtar A, Im R, Greenfield J, Ramamoorthy S, Van Keuren M, Blackburn CC, Tsai CH, Kurnit DM
Genomics. 1996
PubMed ID: 8786137
Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes.
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J Biol Chem. 1995
PubMed ID: 8530383
Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice.
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Nature. 1995
PubMed ID: 7715727
Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.
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Genes Dev. 1994
PubMed ID: 7926765
Interspecific backcrosses provide an important new tool for centromere mapping of mouse chromosomes.
Ceci JD, Matsuda Y, Grubber JM, Jenkins NA, Copeland NG, Chapman VM
Genomics. 1994
PubMed ID: 8188294
Characterization and chromosomal localization of the human proto-oncogene BMI-1.
Alkema MJ, Wiegant J, Raap AK, Berns A, van Lohuizen M
Hum Mol Genet. 1993
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flvi-2, a target of retroviral insertional mutagenesis in feline thymic lymphosarcomas, encodes bmi-1.
Levy LS, Lobelle-Rich PA, Overbaugh J
Oncogene. 1993
PubMed ID: 8390036
Nucleotide sequence of bup, an upstream gene in the bmi-1 proviral insertion locus.
Haupt Y, Barri G, Adams JM
Mol Biol Rep. 1992
PubMed ID: 1287475
A novel zinc finger coiled-coil domain in a family of nuclear proteins.
Reddy BA, Etkin LD, Freemont PS
Trends Biochem Sci. 1992
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Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.
Haupt Y, Alexander WS, Barri G, Klinken SP, Adams JM
Cell. 1991
PubMed ID: 1904009
Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging.
van Lohuizen M, Verbeek S, Scheijen B, Wientjens E, van der Gulden H, Berns A
Cell. 1991
PubMed ID: 1904008
A novel cysteine-rich sequence motif.
Freemont PS, Hanson IM, Trowsdale J
Cell. 1991
PubMed ID: 1991318
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Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	648	12151	307151
EnsEMBL Gene(s)	ENSG00000168283	ENSMUSG00000026739	ENSRNOG00000016585
Unigene	Hs.380403	Mm.289584	Rn.220522
Homologene	BMI1	Bmi1	Bmi1
OMIM	164831	N/A	N/A
GeneCards	BMI1	N/A	N/A
Beta Cell Genomics	DT.450576	DT.536201 DT.97371067	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	648	12151	307151

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Interactor	Interactor	Sources	Classification	Pubmed IDs
BMI1	KAT5	HPRD, MINT, IntAct, BioGRID	empirical	16169070
BMI1	CENPA	BioGRID	empirical	15009096
BMI1	IMMT	HPRD, MINT, IntAct, BioGRID	empirical	16169070
BMI1	PARP1	BioGRID	empirical	20668194
BMI1	CSNK2A1	IntAct	empirical	21282530
BMI1	CSNK2B	IntAct	empirical	21282530
BMI1	DNMT3B	BioGRID	empirical	17726103
BMI1	E2F6	MINT, BioGRID	empirical	11171983
BMI1	PHC1	HPRD, IntAct, MIPS, BioGRID	empirical	9009205 9121482 12167701 19636380 9571155 9199346
BMI1	PHC2	HPRD, IntAct, BioGRID	empirical	9121482 12167701 16359901 19636380 9627119 16751658
BMI1	SCMH1	IntAct, BioGRID	empirical	12167701
BMI1	FOXS1	BioGRID	empirical	20211142
BMI1	CBX6	IntAct	empirical	21282530
BMI1	CBX7	MINT, IntAct, BioGRID	empirical	17332741 21282530 19636380
BMI1	GATA3	BioGRID	empirical	17114435
BMI1	H2AFX	BioGRID	empirical	21383063
BMI1	HSPA4	BioGRID	empirical	12167701
BMI1	MLL	HPRD	empirical	12829790
BMI1	RIF1	IntAct	empirical	16169070
BMI1	LRIF1	HPRD, MINT	empirical	16169070
BMI1	PRKDC	BioGRID	empirical	20668194
BMI1	DMAP1	BioGRID	empirical	17214966
BMI1	CBX8	HPRD, MINT, IntAct, BioGRID	empirical	10825164 17332741 12167701 21282530 16359901 19636380 20601937
BMI1	KIAA1377	HPRD, MINT, IntAct, BioGRID	empirical	16169070
BMI1	PTN	HPRD, MINT, IntAct, BioGRID	empirical	16169070
BMI1	RING1	HPRD, IntAct, BioGRID	empirical	9199346 9858531 12167701 15386022 16359901 19636380 16751658
BMI1	RNF2	HPRD, MINT, IntAct, BioGRID	empirical	12183370 16710298 17296600 12167701 15386022 16359901 19636380 9627119
BMI1	BMI1	HPRD, IntAct, BioGRID	empirical	9858531 16359901
BMI1	SLC11A1	BioGRID	empirical	17726103
BMI1	TOP2A	BioGRID	empirical	19956605
BMI1	UBC	MINT, BioGRID	empirical	19233177 19956605 21430439
BMI1	UBE2D3	BioGRID	empirical	21772249
BMI1	UBE2I	IntAct, BioGRID	empirical	19549727
BMI1	XRCC5	BioGRID	empirical	20668194
BMI1	ZBTB16	HPRD, BioGRID	empirical	12408802
BMI1	USP7	BioGRID	empirical	20601937 20800574
BMI1	PHC3	IntAct, BioGRID	empirical	12167701 19636380 17001316
BMI1	USP11	BioGRID	empirical	20601937
BMI1	HIST2H2AA3	BioGRID	empirical	21179169 21772249
BMI1	HIST2H2AC	BioGRID	empirical	16714294 21772249
BMI1	SPOP	BioGRID	empirical	15897469
BMI1	CUL3	BioGRID	empirical	15897469
BMI1	SMARCA5	IntAct, BioGRID	empirical	12167701
BMI1	KDM2B	IntAct, BioGRID	empirical	17296600
BMI1	CBX2	IntAct, BioGRID	empirical	12167701 21282530 19636380 9571155
BMI1	CBX4	MINT, IntAct, BioGRID	empirical	17332741 12167701 21282530 19636380 12829790 9199346 18453536
BMI1	SOCS2	IntAct	empirical	21988832
BMI1	BTRC	BioGRID	empirical	21430439
BMI1	CDC6	BioGRID	empirical	19462008