SHC1

Summary Top Help

Gene Description:

SHC (Src homology 2 domain containing) transforming protein 1; src homology 2 domain-containing transforming protein C1

Synonyms:

SHC1, SHCA, P66shc, p66shc, p66, Shc1, SHC, ShcA, Shc

Orthologs:

Human SHC1 (protein-coding), Mouse Shc1 (protein-coding), Rat Shc1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr1:154934774..154946959 (12.19 kb) View in Genome Browser

(Mouse) NCBIM37 - chr3:89222365..89233951 (11.59 kb) View in Genome Browser

(Rat) RGSC3.4 - chr2:181616581..181628144 (11.56 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for SHC1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
										no data		no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for SHC1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 9

Biocarta: 34

Reactome: 28

NCI-Nature Pathway Interaction Database: 26

Gene Ontology: 53

MAPK cascade	GO:0000165
Activation of MAPK activity	GO:0000187
Angiogenesis	GO:0001525
Response to hypoxia	GO:0001666
Phosphotyrosine binding	GO:0001784
Protein tyrosine kinase activity	GO:0004713
Transmembrane receptor protein tyrosine kinase adaptor activity	GO:0005068
Epidermal growth factor receptor binding	GO:0005154
Insulin receptor binding	GO:0005158
Insulin-like growth factor receptor binding	GO:0005159
Neurotrophin TRKA receptor binding	GO:0005168
Protein binding	GO:0005515
Phospholipid binding	GO:0005543
Nucleus	GO:0005634
Cytoplasm	GO:0005737
Mitochondrion	GO:0005739
Mitochondrial matrix	GO:0005759
Cytosol	GO:0005829
Plasma membrane	GO:0005886
Activation of signaling protein activity involved in unfolded protein response	GO:0006987
Epidermal growth factor receptor signaling pathway	GO:0007173
Regulation of epidermal growth factor-activated receptor activity	GO:0007176
Ras protein signal transduction	GO:0007265
Heart development	GO:0007507
Aging	GO:0007568
Blood coagulation	GO:0007596
Positive regulation of cell proliferation	GO:0008284
Insulin receptor signaling pathway	GO:0008286
Fibroblast growth factor receptor signaling pathway	GO:0008543
Response to toxin	GO:0009636
Endosome membrane	GO:0010008
Cell-cell adhesion	GO:0016337
Platelet activation	GO:0030168
Neuron differentiation	GO:0030182
Endoplasmic reticulum unfolded protein response	GO:0030968
Organ regeneration	GO:0031100
Neuron projection development	GO:0031175
Actin cytoskeleton reorganization	GO:0031532
Protein complex binding	GO:0032403
Response to insulin stimulus	GO:0032868
Response to nicotine	GO:0035094
Intracellular signal transduction	GO:0035556
Regulation of growth	GO:0040008
Response to hydrogen peroxide	GO:0042542
Positive regulation of DNA replication	GO:0045740
Positive regulation of vasoconstriction	GO:0045907
Ephrin receptor binding	GO:0046875
Nerve growth factor receptor signaling pathway	GO:0048011
Positive regulation of smooth muscle cell proliferation	GO:0048661
Leukocyte migration	GO:0050900
Phosphoprotein binding	GO:0051219
Response to glucocorticoid stimulus	GO:0051384
Shc-EGFR complex	GO:0070435

Publications from PubMed Top Help

Type 1 Diabetes Publications: 2

Publications: 500

HIV gene expression deactivates redox-sensitive stress response program in mouse tubular cells both in vitro and in vivo.
Salhan D, Pathak S, Husain M, Tandon P, Kumar D, Malhotra A, Meggs LG, Singhal PC
Am J Physiol Renal Physiol. 2012
PubMed ID: 21993884
Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-β (TGF-β).
Lin S, Yu L, Yang J, Liu Z, Karia B, Bishop AJ, Jackson J, Lozano G, Copland JA, Mu X, Sun B, Sun LZ
J Biol Chem. 2011
PubMed ID: 22039050
Mitochondrial redox signalling by p66Shc mediates ALS-like disease through Rac1 inactivation.
Pesaresi MG, Amori I, Giorgi C, Ferri A, Fiorenzo P, Gabanella F, Salvatore AM, Giorgio M, Pelicci PG, Pinton P, Carrì MT, Cozzolino M
Hum Mol Genet. 2011
PubMed ID: 21828072
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction.
Zhou S, Chen HZ, Wan YZ, Zhang QJ, Wei YS, Huang S, Liu JJ, Lu YB, Zhang ZQ, Yang RF, Zhang R, Cai H, Liu DP, Liang CC
Circ Res. 2011
PubMed ID: 21778425
Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-beta, and c-Jun N-terminal kinase kinase in human endothelial cells.
Shi Y, Cosentino F, Camici GG, Akhmedov A, Vanhoutte PM, Tanner FC, Lüscher TF
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21817106
Hemodialysis induces p66(shc) gene expression in nondiabetic humans: correlations with oxidative stress and systemic inflammation.
Zanetti M, Barazzoni R, Gortan Cappellari G, Burekovic I, Bosutti A, Stocca A, Bianco F, Ianche M, Panzetta G, Guarnieri G
J Ren Nutr. 2011
PubMed ID: 21439852
P66Shc mediated ferritin degradation--a novel mechanism of ROS formation.
Borkowska A, Sielicka-Dudzin A, Herman-Antosiewicz A, Halon M, Wozniak M, Antosiewicz J
Free Radic Biol Med. 2011
PubMed ID: 21616139
Apurinic/apyrimidinic endonuclease 1 inhibits protein kinase C-mediated p66shc phosphorylation and vasoconstriction.
Lee SK, Chung JI, Park MS, Joo HK, Lee EJ, Cho EJ, Park JB, Ryoo S, Irani K, Jeon BH
Cardiovasc Res. 2011
PubMed ID: 21467074
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptor.
Woldt E, Matz RL, Terrand J, Mlih M, Gracia C, Foppolo S, Martin S, Bruban V, Ji J, Velot E, Herz J, Boucher P
J Biol Chem. 2011
PubMed ID: 21454706
p66Shc is a negative regulator of FcεRI-dependent signaling in mast cells.
Ulivieri C, Fanigliulo D, Masi G, Savino MT, Gamberucci A, Pelicci PG, Baldari CT
J Immunol. 2011
PubMed ID: 21430228
Migration of renal tumor cells depends on dephosphorylation of Shc by PTEN.
Schneider E, Keppler R, Prawitt D, Steinwender C, Roos FC, Thüroff JW, Lausch E, Brenner W
Int J Oncol. 2011
PubMed ID: 21206972
The ShcA phosphotyrosine docking protein uses distinct mechanisms to regulate myocyte and global heart function.
Vanderlaan RD, Hardy WR, Kabir MG, Pasculescu A, Jones N, deTombe PP, Backx PH, Pawson T
Circ Res. 2011
PubMed ID: 21148430
Adaptor protein Shc acts as an immune-regulator for the LPS-stimulated maturation of bone marrow-derived dendritic cells.
Chen KD, Hsu LW, Goto S, Yeh CW, Nakano T, Lai CY, Chang YC, Hou CH, Wang CC, Cheng YF, Chiu KW, Lin CC, Chen CL
BMC Immunol. 2011
PubMed ID: 21612602
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Steroids up-regulate p66Shc longevity protein in growth regulation by inhibiting its ubiquitination.
Kumar S, Kumar S, Rajendran M, Alam SM, Lin FF, Cheng PW, Lin MF
PLoS One. 2011
PubMed ID: 21264241
Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development.
Hawley SP, Wills MK, Rabalski AJ, Bendall AJ, Jones N
Dev Dyn. 2011
PubMed ID: 21117147
Epigenetic enhancement of p66Shc during cellular replicative or premature senescence.
Zhang W, Ji W, Yang L, Xu Y, Yang J, Zhuang Z
Toxicology. 2010
PubMed ID: 20667496
Regulation of intermediary metabolism by the PKCdelta signalosome in mitochondria.
Acin-Perez R, Hoyos B, Gong J, Vinogradov V, Fischman DA, Leitges M, Borhan B, Starkov A, Manfredi G, Hammerling U
FASEB J. 2010
PubMed ID: 20798245
p66(Shc) has a pivotal function in impaired liver regeneration in aged mice by a redox-dependent mechanism.
Haga S, Morita N, Irani K, Fujiyoshi M, Ogino T, Ozawa T, Ozaki M
Lab Invest. 2010
PubMed ID: 20567235
Integrin {beta}3 phosphorylation dictates its complex with the Shc phosphotyrosine-binding (PTB) domain.
Deshmukh L, Gorbatyuk V, Vinogradova O
J Biol Chem. 2010
PubMed ID: 20739287
The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.
Titz B, Low T, Komisopoulou E, Chen SS, Rubbi L, Graeber TG
Oncogene. 2010
PubMed ID: 20697350
Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response.
Ursini-Siegel J, Cory S, Zuo D, Hardy WR, Rexhepaj E, Lam S, Schade B, Jirstrom K, Bjur E, Piccirillo CA, Denardo D, Coussens LM, Brennan DJ, Gallagher WM, Park M, Pawson T, Hallett M, Muller WJ
Cancer Res. 2010
PubMed ID: 20924104
p66(Shc) restrains Ras hyperactivation and suppresses metastatic behavior.
Ma Z, Liu Z, Wu RF, Terada LS
Oncogene. 2010
PubMed ID: 20676142
Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens.
Almeida M, Han L, Ambrogini E, Bartell SM, Manolagas SC
Mol Endocrinol. 2010
PubMed ID: 20685851
The p66shc gene expression in peripheral blood monocytes is increased in patients with coronary artery disease.
Noda Y, Yamagishi S, Matsui T, Ueda S, Ueda S, Jinnouchi Y, Hirai Y, Imaizumi T
Clin Cardiol. 2010
PubMed ID: 20842738
The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing.
Fadini GP, Albiero M, Menegazzo L, Boscaro E, Pagnin E, Iori E, Cosma C, Lapolla A, Pengo V, Stendardo M, Agostini C, Pelicci PG, Giorgio M, Avogaro A
Diabetes. 2010
PubMed ID: 20566667
Oxidative stress alters the regulatory control of p66Shc and Akt in PINK1 deficient cells.
Maj MC, Tkachyova I, Patel P, Addis JB, Mackay N, Levandovskiy V, Lee J, Lang AE, Cameron JM, Robinson BH
Biochem Biophys Res Commun. 2010
PubMed ID: 20637729
Hyperglycemia-induced p66shc inhibits insulin-like growth factor I-dependent cell survival via impairment of Src kinase-mediated phosphoinositide-3 kinase/AKT activation in vascular smooth muscle cells.
Xi G, Shen X, Radhakrishnan Y, Maile L, Clemmons D
Endocrinology. 2010
PubMed ID: 20534722
Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance.
Ranieri SC, Fusco S, Panieri E, Labate V, Mele M, Tesori V, Ferrara AM, Maulucci G, De Spirito M, Martorana GE, Galeotti T, Pani G
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20624962
Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.
Mehlitz A, Banhart S, Mäurer AP, Kaushansky A, Gordus AG, Zielecki J, Macbeath G, Meyer TF
J Cell Biol. 2010
PubMed ID: 20624904
Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression.
Ginés S, Paoletti P, Alberch J
J Biol Chem. 2010
PubMed ID: 20442398
SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence.
Mallette FA, Calabrese V, Ilangumaran S, Ferbeyre G
Aging (Albany NY). 2010
PubMed ID: 20622265
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
Neural-specific inactivation of ShcA functions results in anatomical disorganization of subventricular zone neural stem cell niche in the adult brain.
Ponti G, Reitano E, Aimar P, Cattaneo E, Conti L, Bonfanti L
Neuroscience. 2010
PubMed ID: 20226234
Oxidative stress-dependent p66Shc phosphorylation in skin fibroblasts of children with mitochondrial disorders.
Lebiedzinska M, Karkucinska-Wieckowska A, Giorgi C, Karczmarewicz E, Pronicka E, Pinton P, Duszynski J, Pronicki M, Wieckowski MR
Biochim Biophys Acta. 2010
PubMed ID: 20226758
Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia.
Capitani N, Lucherini OM, Sozzi E, Ferro M, Giommoni N, Finetti F, De Falco G, Cencini E, Raspadori D, Pelicci PG, Lauria F, Forconi F, Baldari CT
Blood. 2010
PubMed ID: 20061561
Greater resistance to inflammation at adulthood could contribute to extended life span of p66(Shc-/-) mice.
Berry A, Carnevale D, Giorgio M, Pelicci PG, de Kloet ER, Alleva E, Minghetti L, Cirulli F
Exp Gerontol. 2010
PubMed ID: 20085805
p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells.
Xiao D, Singh SV
Cancer Res. 2010
PubMed ID: 20354186
Essential role of the redox-sensitive kinase p66shc in determining energetic and oxidative status and cell fate in neuronal preconditioning.
Brown JE, Zeiger SL, Hettinger JC, Brooks JD, Holt B, Morrow JD, Musiek ES, Milne G, McLaughlin B
J Neurosci. 2010
PubMed ID: 20392947
p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis.
Rajendran M, Thomes P, Zhang L, Veeramani S, Lin MF
Cancer Metastasis Rev. 2010
PubMed ID: 20111892
The adaptor protein p66Shc is a positive regulator in the angiogenic response induced by hypoxic T cells.
Naldini A, Morena E, Pucci A, Pellegrini M, Baldari CT, Pelicci PG, Presta M, Ribatti D, Carraro F
J Leukoc Biol. 2010
PubMed ID: 19889727
Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity.
Lucs AV, Muller WJ, Muthuswamy SK
Oncogene. 2010
PubMed ID: 19826412
Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice.
Tomilov AA, Bicocca V, Schoenfeld RA, Giorgio M, Migliaccio E, Ramsey JJ, Hagopian K, Pelicci PG, Cortopassi GA
J Biol Chem. 2010
PubMed ID: 19892704
Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway.
Lee DY, Li YS, Chang SF, Zhou J, Ho HM, Chiu JJ, Chien S
J Biol Chem. 2010
PubMed ID: 19889638
Transcriptional repression of Kruppel like factor-2 by the adaptor protein p66shc.
Kumar A, Hoffman TA, Dericco J, Naqvi A, Jain MK, Irani K
FASEB J. 2009
PubMed ID: 19696221
Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor.
Liu NS, Loo LS, Loh E, Seet LF, Hong W
EMBO J. 2009
PubMed ID: 19798056
The adaptor protein Shc plays a key role during early B cell development.
Giles AJ, Bender TP, Ravichandran KS
J Immunol. 2009
PubMed ID: 19828641
TRIM31 interacts with p52(Shc) and inhibits Src-induced anchorage-independent growth.
Watanabe M, Tsukiyama T, Hatakeyama S
Biochem Biophys Res Commun. 2009
PubMed ID: 19665990
p66(Shc) protein, oxidative stress, and cardiovascular complications of diabetes: the missing link.
Francia P, Cosentino F, Schiavoni M, Huang Y, Perna E, Camici GG, Lüscher TF, Volpe M
J Mol Med. 2009
PubMed ID: 19590843
Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.
Tong J, Taylor P, Peterman SM, Prakash A, Moran MF
Mol Cell Proteomics. 2009
PubMed ID: 19531499
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG, Smith RD, Wiley HS, Qian WJ
J Proteome Res. 2009
PubMed ID: 19534553
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
The cardioprotective effects elicited by p66(Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury.
Carpi A, Menabò R, Kaludercic N, Pelicci P, Di Lisa F, Giorgio M
Biochim Biophys Acta. 2009
PubMed ID: 19362067
Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis.
Husain M, Meggs LG, Vashistha H, Simoes S, Griffiths KO, Kumar D, Mikulak J, Mathieson PW, Saleem MA, Del Valle L, Pina-Oviedo S, Wang JY, Seshan SV, Malhotra A, Reiss K, Singhal PC
J Biol Chem. 2009
PubMed ID: 19383602
Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues.
Lebiedzinska M, Duszynski J, Rizzuto R, Pinton P, Wieckowski MR
Arch Biochem Biophys. 2009
PubMed ID: 19327338
p66ShcA modulates oxidative stress and survival of endothelial progenitor cells in response to high glucose.
Di Stefano V, Cencioni C, Zaccagnini G, Magenta A, Capogrossi MC, Martelli F
Cardiovasc Res. 2009
PubMed ID: 19261622
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
p66(ShcA) adaptor molecule accelerates ES cell neural induction.
Papadimou E, Moiana A, Goffredo D, Koch P, Bertuzzi S, Brüstle O, Cattaneo E, Conti L
Mol Cell Neurosci. 2009
PubMed ID: 19386228
CD247 can bind SHC1, no matter if CD247 is phosphorylated.
Liu T, Chen F, Tang N, Feng J, Zhao D, Wei K, Zhu Y, He F, Liu S
J Mol Recognit. 2009
PubMed ID: 19229850
p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes.
Guo J, Gertsberg Z, Ozgen N, Steinberg SF
Circ Res. 2009
PubMed ID: 19168439
Accelerated failure time models provide a useful statistical framework for aging research.
Swindell WR
Exp Gerontol. 2009
PubMed ID: 19007875
Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis.
Malhotra A, Vashistha H, Yadav VS, Dube MG, Kalra SP, Abdellatif M, Meggs LG
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19060130
Involvement of the p66Shc protein in glucose transport regulation in skeletal muscle myoblasts.
Natalicchio A, De Stefano F, Perrini S, Laviola L, Cignarelli A, Caccioppoli C, Quagliara A, Melchiorre M, Leonardini A, Conserva A, Giorgino F
Am J Physiol Endocrinol Metab. 2009
PubMed ID: 18957618
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
The phagosomal proteome in interferon-gamma-activated macrophages.
Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P
Immunity. 2009
PubMed ID: 19144319
p66Shc-generated oxidative signal promotes fat accumulation.
Berniakovich I, Trinei M, Stendardo M, Migliaccio E, Minucci S, Bernardi P, Pelicci PG, Giorgio M
J Biol Chem. 2008
PubMed ID: 18838380
Human protein factory for converting the transcriptome into an in vitro-expressed proteome,.
Goshima N, Kawamura Y, Fukumoto A, Miura A, Honma R, Satoh R, Wakamatsu A, Yamamoto J, Kimura K, Nishikawa T, Andoh T, Iida Y, Ishikawa K, Ito E, Kagawa N, Kaminaga C, Kanehori K, Kawakami B, Kenmochi K, Kimura R, Kobayashi M, Kuroita T, Kuwayama H, Maruyama Y, Matsuo K, Minami K, Mitsubori M, Mori M, Morishita R, Murase A, Nishikawa A, Nishikawa S, Okamoto T, Sakagami N, Sakamoto Y, Sasaki Y, Seki T, Sono S, Sugiyama A, Sumiya T, Takayama T, Takayama Y, Takeda H, Togashi T, Yahata K, Yamada H, Yanagisawa Y, Endo Y, Imamoto F, Kisu Y, Tanaka S, Isogai T, Imai J, Watanabe S, Nomura N
Nat Methods. 2008
PubMed ID: 19054851
Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2).
Schüller AC, Ahmed Z, Levitt JA, Suen KM, Suhling K, Ladbury JE
Biochem J. 2008
PubMed ID: 18840094
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.
Brummer T, Larance M, Herrera Abreu MT, Lyons RJ, Timpson P, Emmerich CH, Fleuren ED, Lehrbach GM, Schramek D, Guilhaus M, James DE, Daly RJ
EMBO J. 2008
PubMed ID: 19172738
p66Shc deletion confers vascular protection in advanced atherosclerosis in hypercholesterolemic apolipoprotein E knockout mice.
Martin-Padura I, de Nigris F, Migliaccio E, Mansueto G, Minardi S, Rienzo M, Lerman LO, Stendardo M, Giorgio M, De Rosa G, Pelicci PG, Napoli C
Endothelium. 2008
PubMed ID: 19065319
Mitochondrial redox signaling by p66Shc is involved in regulating androgenic growth stimulation of human prostate cancer cells.
Veeramani S, Yuan TC, Lin FF, Lin MF
Oncogene. 2008
PubMed ID: 18504439
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis.
Krause K, Karger S, Sheu SY, Aigner T, Kursawe R, Gimm O, Schmid KW, Dralle H, Fuhrer D
J Endocrinol. 2008
PubMed ID: 18480379
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
Alteration of p66shc is associated with endothelial dysfunction in the abdominal aortic coarctation of rats.
Lee SK, Kim HS, Song YJ, Joo HK, Lee JY, Lee KH, Cho EJ, Cho CH, Park JB, Jeon BH
FEBS Lett. 2008
PubMed ID: 18588882
Shc coordinates signals from intercellular junctions and integrins to regulate flow-induced inflammation.
Liu Y, Sweet DT, Irani-Tehrani M, Maeda N, Tzima E
J Cell Biol. 2008
PubMed ID: 18606845
Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II.
Feigelson HS, Teras LR, Diver WR, Tang W, Patel AV, Stevens VL, Calle EE, Thun MJ, Bouzyk M
Breast Cancer Res. 2008
PubMed ID: 18611262
Role of the life span determinant P66(shcA) in ethanol-induced liver damage.
Koch OR, Fusco S, Ranieri SC, Maulucci G, Palozza P, Larocca LM, Cravero AA, Farre' SM, De Spirito M, Galeotti T, Pani G
Lab Invest. 2008
PubMed ID: 18490896
Insulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells.
Radhakrishnan Y, Maile LA, Ling Y, Graves LM, Clemmons DR
J Biol Chem. 2008
PubMed ID: 18420583
Endothelin-1 couples betaPix to p66Shc: role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt.
Chahdi A, Sorokin A
Mol Biol Cell. 2008
PubMed ID: 18385518
The proapoptotic and antimitogenic protein p66SHC acts as a negative regulator of lymphocyte activation and autoimmunity.
Finetti F, Pellegrini M, Ulivieri C, Savino MT, Paccagnini E, Ginanneschi C, Lanfrancone L, Pelicci PG, Baldari CT
Blood. 2008
PubMed ID: 18334675
Activation of the lifespan regulator p66Shc through reversible disulfide bond formation.
Gertz M, Fischer F, Wolters D, Steegborn C
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18413607
A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein.
George R, Schuller AC, Harris R, Ladbury JE
J Mol Biol. 2008
PubMed ID: 18279888
ShcA signalling is essential for tumour progression in mouse models of human breast cancer.
Ursini-Siegel J, Hardy WR, Zuo D, Lam SH, Sanguin-Gendreau V, Cardiff RD, Pawson T, Muller WJ
EMBO J. 2008
PubMed ID: 18273058
p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells.
Arany I, Faisal A, Nagamine Y, Safirstein RL
J Biol Chem. 2008
PubMed ID: 18174162
Preventing hypoxia/reoxygenation damage to hepatocytes by p66(shc) ablation: up-regulation of anti-oxidant and anti-apoptotic proteins.
Haga S, Terui K, Fukai M, Oikawa Y, Irani K, Furukawa H, Todo S, Ozaki M
J Hepatol. 2008
PubMed ID: 18191273
The Met tyrosine kinase receptor in development and cancer.
Gentile A, Trusolino L, Comoglio PM
Cancer Metastasis Rev. 2008
PubMed ID: 18175071
Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.
Berry A, Greco A, Giorgio M, Pelicci PG, de Kloet R, Alleva E, Minghetti L, Cirulli F
Exp Gerontol. 2008
PubMed ID: 18065182
Protein-tyrosine phosphatase epsilon regulates Shc signaling in a kinase-specific manner: increasing coherence in tyrosine phosphatase signaling.
Kraut-Cohen J, Muller WJ, Elson A
J Biol Chem. 2008
PubMed ID: 18093973
Influence of obesity and insulin sensitivity on insulin signaling genes in human omental and subcutaneous adipose tissue.
MacLaren R, Cui W, Simard S, Cianflone K
J Lipid Res. 2008
PubMed ID: 17986714
The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways.
de Totero D, Meazza R, Capaia M, Fabbi M, Azzarone B, Balleari E, Gobbi M, Cutrona G, Ferrarini M, Ferrini S
Blood. 2008
PubMed ID: 17938255
Serial analysis of gene expression reveals differential expression between endometriosis and normal endometrium. Possible roles for AXL and SHC1 in the pathogenesis of endometriosis.
Honda H, Barrueto FF, Gogusev J, Im DD, Morin PJ
Reprod Biol Endocrinol. 2008
PubMed ID: 19055724
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
Ballif BA, Carey GR, Sunyaev SR, Gygi SP
J Proteome Res. 2008
PubMed ID: 18034455
AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation.
Cai W, He JC, Zhu L, Chen X, Striker GE, Vlassara H
Am J Physiol Cell Physiol. 2008
PubMed ID: 18032526
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
Overexpression of the elongation factor 1A1 relates to muscle proteolysis and proapoptotic p66(ShcA) gene transcription in hypercatabolic trauma patients.
Bosutti A, Scaggiante B, Grassi G, Guarnieri G, Biolo G
Metabolism. 2007
PubMed ID: 17998013
Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses.
Jensen M, Hansen B, De Meyts P, Schäffer L, Ursø B
J Biol Chem. 2007
PubMed ID: 17925406
The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis.
Ramshaw HS, Guthridge MA, Stomski FC, Barry EF, Ooms L, Mitchell CA, Begley CG, Lopez AF
Blood. 2007
PubMed ID: 17638849
Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
Cao L, Yu K, Banh C, Nguyen V, Ritz A, Raphael BJ, Kawakami Y, Kawakami T, Salomon AR
J Immunol. 2007
PubMed ID: 17947660
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD
J Proteome Res. 2007
PubMed ID: 17924679
p66(ShcA) and oxidative stress modulate myogenic differentiation and skeletal muscle regeneration after hind limb ischemia.
Zaccagnini G, Martelli F, Magenta A, Cencioni C, Fasanaro P, Nicoletti C, Biglioli P, Pelicci PG, Capogrossi MC
J Biol Chem. 2007
PubMed ID: 17726026
p66 Shc tumor levels show a strong prognostic correlation with disease outcome in stage IIA colon cancer.
Grossman SR, Lyle S, Resnick MB, Sabo E, Lis RT, Rosinha E, Liu Q, Hsieh CC, Bhat G, Frackelton AR, Hafer LJ
Clin Cancer Res. 2007
PubMed ID: 17908971
Src homology domain 2 adaptors affect adherence of Salmonella enterica serovar Typhimurium to non-phagocytic cells.
Boyle EC, Brown NF, Brumell JH, Finlay BB
Microbiology. 2007
PubMed ID: 17906149
TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA.
Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R
EMBO J. 2007
PubMed ID: 17673906
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation.
Menini S, Iacobini C, Ricci C, Oddi G, Pesce C, Pugliese F, Block K, Abboud HE, Giorgio M, Migliaccio E, Pelicci PG, Pugliese G
Diabetologia. 2007
PubMed ID: 17611735
Antagonism of p66shc by melanoma inhibitory activity.
Kasuno K, Naqvi A, Dericco J, Yamamori T, Santhanam L, Mattagajasingh I, Yang S, Meyskens FL, Bosserhoff AK, Irani K
Cell Death Differ. 2007
PubMed ID: 17431427
Combinatorial ShcA docking interactions support diversity in tissue morphogenesis.
Hardy WR, Li L, Wang Z, Sedy J, Fawcett J, Frank E, Kucera J, Pawson T
Science. 2007
PubMed ID: 17626887
A systems biology approach to the pathogenesis of obesity-related nonalcoholic fatty liver disease using reverse phase protein microarrays for multiplexed cell signaling analysis.
Calvert VS, Collantes R, Elariny H, Afendy A, Baranova A, Mendoza M, Goodman Z, Liotta LA, Petricoin EF, Younossi ZM
Hepatology. 2007
PubMed ID: 17596878
Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes.
Balbis A, Parmar A, Wang Y, Baquiran G, Posner BI
Endocrinology. 2007
PubMed ID: 17363458
Regulation of PDGF-stimulated SHIP2 tyrosine phosphorylation and association with Shc in 3T3-L1 preadipocytes.
Artemenko Y, Gagnon A, Ibrahim S, Sorisky A
J Cell Physiol. 2007
PubMed ID: 17219406
p66Shc is involved in promoting HIF-1alpha accumulation and cell death in hypoxic T cells.
Carraro F, Pucci A, Pellegrini M, Pelicci PG, Baldari CT, Naldini A
J Cell Physiol. 2007
PubMed ID: 17167775
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks.
Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17389395
Regulation of insulin receptor function.
Youngren JF
Cell Mol Life Sci. 2007
PubMed ID: 17347799
Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling.
Erkeland SJ, Aarts LH, Irandoust M, Roovers O, Klomp A, Valkhof M, Gits J, Eyckerman S, Tavernier J, Touw IP
Oncogene. 2007
PubMed ID: 17001306
Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.
Camici GG, Schiavoni M, Francia P, Bachschmid M, Martin-Padura I, Hersberger M, Tanner FC, Pelicci P, Volpe M, Anversa P, Lüscher TF, Cosentino F
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360381
Relation between the plasma levels of LDL-cholesterol and the expression of the early marker of inflammation long pentraxin PTX3 and the stress response gene p66ShcA in pacemaker-implanted patients.
Bosutti A, Grassi G, Zanetti M, Aleksova A, Zecchin M, Sinagra G, Biolo G, Guarnieri G
Clin Exp Med. 2007
PubMed ID: 17380301
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G, Martin P, Rogers J, Lawlor S, McLaren S, Dricot A, Borick H, Cusick ME, Vandenhaute J, Dunham I, Hill DE, Vidal M
Genomics. 2007
PubMed ID: 17207965
p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres.
Sansone P, Storci G, Giovannini C, Pandolfi S, Pianetti S, Taffurelli M, Santini D, Ceccarelli C, Chieco P, Bonafé M
Stem Cells. 2007
PubMed ID: 17158237
ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation.
Degoutin J, Vigny M, Gouzi JY
FEBS Lett. 2007
PubMed ID: 17274988
Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc.
Pinton P, Rimessi A, Marchi S, Orsini F, Migliaccio E, Giorgio M, Contursi C, Minucci S, Mantovani F, Wieckowski MR, Del Sal G, Pelicci PG, Rizzuto R
Science. 2007
PubMed ID: 17272725
Inhibition of wild-type p66ShcA in mesangial cells prevents glycooxidant-dependent FOXO3a regulation and promotes the survival phenotype.
Chintapalli J, Yang S, Opawumi D, Goyal SR, Shamsuddin N, Malhotra A, Reiss K, Meggs LG
Am J Physiol Renal Physiol. 2007
PubMed ID: 17077388
Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cells.
Wada T, Naito M, Kenmochi H, Tsuneki H, Sasaoka T
Endocrinology. 2007
PubMed ID: 17068140
PKC delta phosphorylates p52ShcA at Ser29 to regulate ERK activation in response to H2O2.
Hu Y, Kang C, Philp RJ, Li B
Cell Signal. 2007
PubMed ID: 16963224
Decreased p66Shc promoter methylation in patients with end-stage renal disease.
Geisel J, Schorr H, Heine GH, Bodis M, Hübner U, Knapp JP, Herrmann W
Clin Chem Lab Med. 2007
PubMed ID: 18067454
Elevated insulin signaling disrupts the growth and differentiation pattern of the mouse lens.
Xie L, Chen H, Overbeek PA, Reneker LW
Mol Vis. 2007
PubMed ID: 17417601
Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice.
Berry A, Capone F, Giorgio M, Pelicci PG, de Kloet ER, Alleva E, Minghetti L, Cirulli F
Exp Gerontol. 2007
PubMed ID: 16809014
Amyloid precursor protein modulates ERK-1 and -2 signaling.
Venezia V, Nizzari M, Repetto E, Violani E, Corsaro A, Thellung S, Villa V, Carlo P, Schettini G, Florio T, Russo C
Ann N Y Acad Sci. 2006
PubMed ID: 17384289
ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development.
Trampont P, Zhang L, Ravichandran KS
Mol Cell Biol. 2006
PubMed ID: 16982683
Reduction of p66Shc suppresses oxidative damage in retinal pigmented epithelial cells and retina.
Wu Z, Rogers B, Kachi S, Hackett SF, Sick A, Campochiaro PA
J Cell Physiol. 2006
PubMed ID: 16972253
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Expression in T-cells of the proapoptotic protein p66SHC is controlled by promoter demethylation.
Pezzicoli A, Ulivieri C, Capitani N, Ventura A, Pelicci P, Baldari CT
Biochem Biophys Res Commun. 2006
PubMed ID: 16934220
Regulatory effects of the mitochondrial energetic status on mitochondrial p66Shc.
Orsini F, Moroni M, Contursi C, Yano M, Pelicci P, Giorgio M, Migliaccio E
Biol Chem. 2006
PubMed ID: 17081113
The role of Src kinase in insulin-like growth factor-dependent mitogenic signaling in vascular smooth muscle cells.
Lieskovska J, Ling Y, Badley-Clarke J, Clemmons DR
J Biol Chem. 2006
PubMed ID: 16825188
Lck couples Shc to TCR signaling.
Fukushima A, Hatanaka Y, Chang JW, Takamatsu M, Singh N, Iwashima M
Cell Signal. 2006
PubMed ID: 16257509
Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly.
McFarland KN, Wilkes SR, Koss SE, Ravichandran KS, Mandell JW
J Neurosci. 2006
PubMed ID: 16870734
Mutant Tie2 causing venous malformation signals through Shc.
Morris PN, Dunmore BJ, Brindle NP
Biochem Biophys Res Commun. 2006
PubMed ID: 16756945
Distinct signaling functions for Shc isoforms in the heart.
Obreztchikova M, Elouardighi H, Ho M, Wilson BA, Gertsberg Z, Steinberg SF
J Biol Chem. 2006
PubMed ID: 16699171
Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene.
Rota M, LeCapitaine N, Hosoda T, Boni A, De Angelis A, Padin-Iruegas ME, Esposito G, Vitale S, Urbanek K, Casarsa C, Giorgio M, Lüscher TF, Pelicci PG, Anversa P, Leri A, Kajstura J
Circ Res. 2006
PubMed ID: 16763167
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.
Wang SE, Narasanna A, Perez-Torres M, Xiang B, Wu FY, Yang S, Carpenter G, Gazdar AF, Muthuswamy SK, Arteaga CL
Cancer Cell. 2006
PubMed ID: 16843263
EGF-ERBB signalling: towards the systems level.
Citri A, Yarden Y
Nat Rev Mol Cell Biol. 2006
PubMed ID: 16829981
Activation of the lutropin/choriogonadotropin receptor in MA-10 cells stimulates tyrosine kinase cascades that activate ras and the extracellular signal regulated kinases (ERK1/2).
Shiraishi K, Ascoli M
Endocrinology. 2006
PubMed ID: 16614081
Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress.
Menini S, Amadio L, Oddi G, Ricci C, Pesce C, Pugliese F, Giorgio M, Migliaccio E, Pelicci P, Iacobini C, Pugliese G
Diabetes. 2006
PubMed ID: 16731826
The DNA sequence and biological annotation of human chromosome 1.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E
Nature. 2006
PubMed ID: 16710414
Mitochondrial DNA copy number is regulated by cellular proliferation: a role for Ras and p66(Shc).
Trinei M, Berniakovich I, Pelicci PG, Giorgio M
Biochim Biophys Acta. 2006
PubMed ID: 16829231
beta1 integrins modulate p66ShcA expression and EGF-induced MAP kinase activation in fetal lung cells.
Smith SM, Crowe DL, Lee MK
Biochem Biophys Res Commun. 2006
PubMed ID: 16517240
The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism.
Nemoto S, Combs CA, French S, Ahn BH, Fergusson MM, Balaban RS, Finkel T
J Biol Chem. 2006
PubMed ID: 16481327
p66(Shc) gene has a pro-apoptotic role in human cell lines and it is activated by a p53-independent pathway.
Tiberi L, Faisal A, Rossi M, Di Tella L, Franceschi C, Salvioli S
Biochem Biophys Res Commun. 2006
PubMed ID: 16487929
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway.
Toschi E, Bacigalupo I, Strippoli R, Chiozzini C, Cereseto A, Falchi M, Nappi F, Sgadari C, Barillari G, Mainiero F, Ensoli B
Mol Biol Cell. 2006
PubMed ID: 16436505
Sos-mediated activation of rac1 by p66shc.
Khanday FA, Santhanam L, Kasuno K, Yamamori T, Naqvi A, Dericco J, Bugayenko A, Mattagajasingh I, Disanza A, Scita G, Irani K
J Cell Biol. 2006
PubMed ID: 16520382
Regulation of amygdala-dependent learning by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol-3-kinase.
Ou LC, Gean PW
Neuropsychopharmacology. 2006
PubMed ID: 16034442
Search for genetic variants in the p66Shc longevity gene by PCR-single strand conformational polymorphism in patients with early-onset cardiovascular disease.
Sentinelli F, Romeo S, Barbetti F, Berni A, Filippi E, Fanelli M, Fallarino M, Baroni MG
BMC Genet. 2006
PubMed ID: 16519809
p53 and p66 proteins compete for hypoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia.
Bianchi G, Di Giulio C, Rapino C, Rapino M, Antonucci A, Cataldi A
Gerontology. 2006
PubMed ID: 16439820
Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1.
Jiang ST, Chiou YY, Wang E, Lin HK, Lin YT, Chi YC, Wang CK, Tang MJ, Li H
Am J Pathol. 2006
PubMed ID: 16400024
Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress.
Khanday FA, Yamamori T, Mattagajasingh I, Zhang Z, Bugayenko A, Naqvi A, Santhanam L, Nabi N, Kasuno K, Day BW, Irani K
Mol Biol Cell. 2006
PubMed ID: 16251354
P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction.
Yamamori T, White AR, Mattagajasingh I, Khanday FA, Haile A, Qi B, Jeon BH, Bugayenko A, Kasuno K, Berkowitz DE, Irani K
J Mol Cell Cardiol. 2005
PubMed ID: 16242150
Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation.
Yang K, Kim JH, Kim HJ, Park IS, Kim IY, Yang BS
J Biol Chem. 2005
PubMed ID: 16186108
Expression of p66(Shc) protein correlates with proliferation of human prostate cancer cells.
Veeramani S, Igawa T, Yuan TC, Lin FF, Lee MS, Lin JS, Johansson SL, Lin MF
Oncogene. 2005
PubMed ID: 16170380
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
Intrinsic regulation of the interactions between the SH3 domain of p85 subunit of phosphatidylinositol-3 kinase and the protein network of BCR/ABL oncogenic tyrosine kinase.
Ren SY, Xue F, Feng J, Skorski T
Exp Hematol. 2005
PubMed ID: 16219545
Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand.
Humtsoe JO, Bowling RA, Feng S, Wary KK
Biochem Biophys Res Commun. 2005
PubMed ID: 16099422
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.
Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM
Mol Cell Proteomics. 2005
PubMed ID: 15951569
Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage.
Graiani G, Lagrasta C, Migliaccio E, Spillmann F, Meloni M, Madeddu P, Quaini F, Padura IM, Lanfrancone L, Pelicci P, Emanueli C
Hypertension. 2005
PubMed ID: 15998704
p66(shc) is highly expressed in fibroblasts from centenarians.
Pandolfi S, Bonafè M, Di Tella L, Tiberi L, Salvioli S, Monti D, Sorbi S, Franceschi C
Mech Ageing Dev. 2005
PubMed ID: 15992607
Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity.
Santen RJ, Song RX, Zhang Z, Kumar R, Jeng MH, Masamura A, Lawrence J, Berstein L, Yue W
Endocr Relat Cancer. 2005
PubMed ID: 16113100
Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells.
Ling Y, Maile LA, Lieskovska J, Badley-Clarke J, Clemmons DR
Mol Biol Cell. 2005
PubMed ID: 15888547
Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis.
Tachibana K, Jones N, Dumont DJ, Puri MC, Bernstein A
Mol Cell Biol. 2005
PubMed ID: 15899871
p66Shc expression in proliferating thyroid cells is regulated by thyrotropin receptor signaling.
Park YJ, Kim TY, Lee SH, Kim H, Kim SW, Shong M, Yoon YK, Cho BY, Park DJ
Endocrinology. 2005
PubMed ID: 15705774
Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.
Smith WW, Norton DD, Gorospe M, Jiang H, Nemoto S, Holbrook NJ, Finkel T, Kusiak JW
J Cell Biol. 2005
PubMed ID: 15837797
Enhanced expression of p46 Shc in the nucleus and p52 Shc in the cytoplasm of human gastric cancer.
Yukimasa S, Masaki T, Yoshida S, Uchida N, Watanabe S, Usuki H, Yoshiji H, Maeta T, Ebara K, Nakatsu T, Kurokohchi K, Kuriyama S
Int J Oncol. 2005
PubMed ID: 15753984
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.
Thelemann A, Petti F, Griffin G, Iwata K, Hunt T, Settinari T, Fenyo D, Gibson N, Haley JD
Mol Cell Proteomics. 2005
PubMed ID: 15657067
Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival.
Patrussi L, Savino MT, Pellegrini M, Paccani SR, Migliaccio E, Plyte S, Lanfrancone L, Pelicci PG, Baldari CT
Oncogene. 2005
PubMed ID: 15688026
RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251.
Kiely PA, Leahy M, O'Gorman D, O'Connor R
J Biol Chem. 2005
PubMed ID: 15611085
Transient activation of Ras-dependent signalling at the early stages of Herbimycin A induced erythroid differentiation of human K562 cells.
Drobot L, Husak Z, Ilnytska O, Igumentseva N, Oleksyn H, Kusen' S
Exp Oncol. 2005
PubMed ID: 15812354
Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor.
Miyamoto Y, Chen L, Sato M, Sokabe M, Nabeshima T, Pawson T, Sakai R, Mori N
J Neurosci. 2005
PubMed ID: 15716419
p66ShcA and ageing: modulation by longevity-promoting agent aurintricarboxylic acid.
Sagi O, Wolfson M, Utko N, Muradian K, Fraifeld V
Mech Ageing Dev. 2005
PubMed ID: 15621204
Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells: relationship to oxidative stress.
Pagnin E, Fadini G, de Toni R, Tiengo A, Calò L, Avogaro A
J Clin Endocrinol Metab. 2005
PubMed ID: 15562031
Phosphotyrosine interactome of the ErbB-receptor kinase family.
Schulze WX, Deng L, Mann M
Mol Syst Biol. 2005
PubMed ID: 16729043
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ
Nat Biotechnol. 2005
PubMed ID: 15592455
Substrate-trapping techniques in the identification of cellular PTP targets.
Blanchetot C, Chagnon M, Dubé N, Hallé M, Tremblay ML
Methods. 2005
PubMed ID: 15588985
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
The insulin-like growth factor-1 pathway mediator genes: SHC1 Met300Val shows a protective effect in breast cancer.
Wagner K, Hemminki K, Grzybowska E, Klaes R, Butkiewicz D, Pamula J, Pekala W, Zientek H, Mielzynska D, Siwinska E, Försti A
Carcinogenesis. 2004
PubMed ID: 15308584
Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4.
Hinsby AM, Olsen JV, Mann M
J Biol Chem. 2004
PubMed ID: 15316024
Deletion of p66shc gene protects against age-related endothelial dysfunction.
Francia P, delli Gatti C, Bachschmid M, Martin-Padura I, Savoia C, Migliaccio E, Pelicci PG, Schiavoni M, Lüscher TF, Volpe M, Cosentino F
Circulation. 2004
PubMed ID: 15505103
ShcA regulates neurite outgrowth stimulated by neural cell adhesion molecule but not by fibroblast growth factor 2: evidence for a distinct fibroblast growth factor receptor response to neural cell adhesion molecule activation.
Hinsby AM, Lundfald L, Ditlevsen DK, Korshunova I, Juhl L, Meakin SO, Berezin V, Bock E
J Neurochem. 2004
PubMed ID: 15485499
Signal transduction via the stem cell factor receptor/c-Kit.
Rönnstrand L
Cell Mol Life Sci. 2004
PubMed ID: 15526160
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.
Tacconelli A, Farina AR, Cappabianca L, Desantis G, Tessitore A, Vetuschi A, Sferra R, Rucci N, Argenti B, Screpanti I, Gulino A, Mackay AR
Cancer Cell. 2004
PubMed ID: 15488758
Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats.
Yoshida S, Masaki T, Feng H, Yuji J, Miyauchi Y, Funaki T, Yoshiji H, Matsumoto K, Uchida N, Watanabe S, Kurokohchi K, Kuriyama S
Int J Oncol. 2004
PubMed ID: 15375560
Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules.
Ranganathan S, Liu CX, Migliorini MM, Von Arnim CA, Peltan ID, Mikhailenko I, Hyman BT, Strickland DK
J Biol Chem. 2004
PubMed ID: 15272003
CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells.
Murayama Y, Miyagawa J, Oritani K, Yoshida H, Yamamoto K, Kishida O, Miyazaki T, Tsutsui S, Kiyohara T, Miyazaki Y, Higashiyama S, Matsuzawa Y, Shinomura Y
J Cell Sci. 2004
PubMed ID: 15226408
Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress.
Wang JF, Zhang X, Groopman JE
J Biol Chem. 2004
PubMed ID: 15102829
p66ShcA modulates tissue response to hindlimb ischemia.
Zaccagnini G, Martelli F, Fasanaro P, Magenta A, Gaetano C, Di Carlo A, Biglioli P, Giorgio M, Martin-Padura I, Pelicci PG, Capogrossi MC
Circulation. 2004
PubMed ID: 15173034
Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning.
Koponen E, Võikar V, Riekki R, Saarelainen T, Rauramaa T, Rauvala H, Taira T, Castrén E
Mol Cell Neurosci. 2004
PubMed ID: 15121188
Identification of p46 Shc expressed in the nuclei of hepatocytes with high proliferating activity: Study of regenerating rat liver.
Yuji J, Masaki T, Yoshida S, Kita Y, Feng H, Uchida N, Yoshiji H, Kitanaka A, Watanabe S, Kurokohchi K, Kuriyama S
Int J Mol Med. 2004
PubMed ID: 15067377
P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity.
Yannoni YM, Gaestel M, Lin LL
FEBS Lett. 2004
PubMed ID: 15094067
Tyrosine-317 of p52(Shc) mediates androgen-stimulated proliferation signals in human prostate cancer cells.
Lee MS, Igawa T, Lin MF
Oncogene. 2004
PubMed ID: 14990987
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study.
Puskás LG, Nagy ZB, Giricz Z, Onody A, Csonka C, Kitajka K, Hackler L, Zvara A, Ferdinandy P
FEBS Lett. 2004
PubMed ID: 15044008
Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells.
Audero E, Cascone I, Maniero F, Napione L, Arese M, Lanfrancone L, Bussolino F
J Biol Chem. 2004
PubMed ID: 14665640
Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells.
Carloni V, Mazzocca A, Ravichandran KS
Oncogene. 2004
PubMed ID: 14676841
The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis.
Saucier C, Khoury H, Lai KM, Peschard P, Dankort D, Naujokas MA, Holash J, Yancopoulos GD, Muller WJ, Pawson T, Park M
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14983012
The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane.
Song RX, Barnes CJ, Zhang Z, Bao Y, Kumar R, Santen RJ
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14764897
Bioinformatics and cellular signaling.
Papin J, Subramaniam S
Curr Opin Biotechnol. 2004
PubMed ID: 15102471
Variation in the SHC1 gene and longevity in humans.
Mooijaart SP, van Heemst D, Schreuder J, van Gerwen S, Beekman M, Brandt BW, Eline Slagboom P, Westendorp RG, 'Long Life' Study Group
Exp Gerontol. 2004
PubMed ID: 15036421
p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.
Pacini S, Pellegrini M, Migliaccio E, Patrussi L, Ulivieri C, Ventura A, Carraro F, Naldini A, Lanfrancone L, Pelicci P, Baldari CT
Mol Cell Biol. 2004
PubMed ID: 14749389
Non-redundant role of Shc in Erk activation by cytoskeletal reorganization.
Faisal A, Kleiner S, Nagamine Y
J Biol Chem. 2004
PubMed ID: 14576154
A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria.
Ventura A, Maccarana M, Raker VA, Pelicci PG
J Biol Chem. 2004
PubMed ID: 14573619
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Met, metastasis, motility and more.
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF
Nat Rev Mol Cell Biol. 2003
PubMed ID: 14685170
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Genetic mouse models of extended lifespan.
Liang H, Masoro EJ, Nelson JF, Strong R, McMahan CA, Richardson A
Exp Gerontol. 2003
PubMed ID: 14698816
The retardation of aging by caloric restriction: its significance in the transgenic era.
Barger JL, Walford RL, Weindruch R
Exp Gerontol. 2003
PubMed ID: 14698815
Association analysis of the SHC1 gene locus with longevity in the Japanese population.
Kamei H, Adati N, Arai Y, Yamamura K, Takayama M, Nakazawa S, Ebihara Y, Gondo Y, Akechi M, Noguchi T, Hirose N, Sakaki Y, Kojima T
J Mol Med. 2003
PubMed ID: 14530863
Regulation of endogenous SH2 domain-containing inositol 5-phosphatase (SHIP2) in 3T3-L1 and human preadipocytes.
Gagnon A, Artemenko Y, Crapper T, Sorisky A
J Cell Physiol. 2003
PubMed ID: 14502564
Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins.
Howard PL, Chia MC, Del Rizzo S, Liu FF, Pawson T
Proc Natl Acad Sci U S A. 2003
PubMed ID: 13679576
Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor.
Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T
J Biol Chem. 2003
PubMed ID: 12871937
Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells.
Buerger C, Nagel-Wolfrum K, Kunz C, Wittig I, Butz K, Hoppe-Seyler F, Groner B
J Biol Chem. 2003
PubMed ID: 12842895
Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells.
Sasaoka T, Kikuchi K, Wada T, Sato A, Hori H, Murakami S, Fukui K, Ishihara H, Aota R, Kimura I, Kobayashi M
Endocrinology. 2003
PubMed ID: 12933696
EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.
Vindis C, Cerretti DP, Daniel TO, Huynh-Do U
J Cell Biol. 2003
PubMed ID: 12925710
The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation.
Sayeski PP, Ali MS
Exp Cell Res. 2003
PubMed ID: 12837289
Gab1 is an integrator of cell death versus cell survival signals in oxidative stress.
Holgado-Madruga M, Wong AJ
Mol Cell Biol. 2003
PubMed ID: 12808090
v-Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL receptor-related protein 1.
Barnes H, Ackermann EJ, van der Geer P
Oncogene. 2003
PubMed ID: 12789267
Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression.
Wong N, Chan A, Lee SW, Lam E, To KF, Lai PB, Li XN, Liew CT, Johnson PJ
J Hepatol. 2003
PubMed ID: 12586295
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.
Blagoev B, Kratchmarova I, Ong SE, Nielsen M, Foster LJ, Mann M
Nat Biotechnol. 2003
PubMed ID: 12577067
Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity.
Tong J, Elowe S, Nash P, Pawson T
J Biol Chem. 2003
PubMed ID: 12486127
Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.
Napoli C, Martin-Padura I, de Nigris F, Giorgio M, Mansueto G, Somma P, Condorelli M, Sica G, De Rosa G, Pelicci P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12571362
Differential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairment.
Jiang X, Edstrom E, Altun M, Ulfhake B
Aging Cell. 2003
PubMed ID: 12882334
Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck.
Niu S, Xie H, Marcantonio EE
Mol Biol Cell. 2003
PubMed ID: 12589038
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12522270
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.
Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N
Mol Cell Biol. 2002
PubMed ID: 12446789
Mechanism for differential effect of protein-tyrosine phosphatase 1B on Akt versus mitogen-activated protein kinase in 3T3-L1 adipocytes.
Shimizu S, Maegawa H, Egawa K, Shi K, Bryer-Ash M, Kashiwagi A
Endocrinology. 2002
PubMed ID: 12446583
Distinct usages of phospholipase C gamma and Shc in intracellular signaling stimulated by neurotrophins.
Yamada M, Numakawa T, Koshimizu H, Tanabe K, Wada K, Koizumi S, Hatanaka H
Brain Res. 2002
PubMed ID: 12419535
Fear memory formation involves p190 RhoGAP and ROCK proteins through a GRB2-mediated complex.
Lamprecht R, Farb CR, LeDoux JE
Neuron. 2002
PubMed ID: 12441060
Signal transduction through tyrosine-phosphorylated carboxy-terminal fragments of APP via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.
Russo C, Dolcini V, Salis S, Venezia V, Violani E, Carlo P, Zambrano N, Russo T, Schettini G
Ann N Y Acad Sci. 2002
PubMed ID: 12485888
Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade.
Pratt RL, Kinch MS
Oncogene. 2002
PubMed ID: 12400011
Phosphatidylinositol 3-kinase regulates glycosylphosphatidylinositol hydrolysis through PLC-gamma(2) activation in erythropoietin-stimulated cells.
Boudot C, Kadri Z, Petitfrère E, Lambert E, Chrétien S, Mayeux P, Haye B, Billat C
Cell Signal. 2002
PubMed ID: 12135708
Mechanism of TrkB-mediated hippocampal long-term potentiation.
Minichiello L, Calella AM, Medina DL, Bonhoeffer T, Klein R, Korte M
Neuron. 2002
PubMed ID: 12367511
Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc.
Roccato E, Miranda C, Ranzi V, Gishizki M, Pierotti MA, Greco A
Br J Cancer. 2002
PubMed ID: 12237775
Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1.
Dalle S, Imamura T, Rose DW, Worrall DS, Ugi S, Hupfeld CJ, Olefsky JM
Mol Cell Biol. 2002
PubMed ID: 12167719
Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling.
Faisal A, el-Shemerly M, Hess D, Nagamine Y
J Biol Chem. 2002
PubMed ID: 12052829
Adaptor protein Shc is an isoform-specific direct activator of the tyrosine kinase c-Src.
Sato K, Nagao T, Kakumoto M, Kimoto M, Otsuki T, Iwasaki T, Tokmakov AA, Owada K, Fukami Y
J Biol Chem. 2002
PubMed ID: 12048194
A nonredundant role for the adapter protein Shc in thymic T cell development.
Zhang L, Camerini V, Bender TP, Ravichandran KS
Nat Immunol. 2002
PubMed ID: 12101399
Hypoxic induction of the hypoxia-inducible factor is mediated via the adaptor protein Shc in endothelial cells.
Jung F, Haendeler J, Hoffmann J, Reissner A, Dernbach E, Zeiher AM, Dimmeler S
Circ Res. 2002
PubMed ID: 12114320
The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter.
Ventura A, Luzi L, Pacini S, Baldari CT, Pelicci PG
J Biol Chem. 2002
PubMed ID: 11948181
Protein kinase C-delta is a negative regulator of antigen-induced mast cell degranulation.
Leitges M, Gimborn K, Elis W, Kalesnikoff J, Hughes MR, Krystal G, Huber M
Mol Cell Biol. 2002
PubMed ID: 12024011
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.
Trinei M, Giorgio M, Cicalese A, Barozzi S, Ventura A, Migliaccio E, Milia E, Padura IM, Raker VA, Maccarana M, Petronilli V, Minucci S, Bernardi P, Lanfrancone L, Pelicci PG
Oncogene. 2002
PubMed ID: 12032825
Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen.
Ikeda K, Wang LH, Torres R, Zhao H, Olaso E, Eng FJ, Labrador P, Klein R, Lovett D, Yancopoulos GD, Friedman SL, Lin HC
J Biol Chem. 2002
PubMed ID: 11884411
Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor.
Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ
Biochemistry. 2002
PubMed ID: 12009895
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.
Tarr PE, Roncarati R, Pelicci G, Pelicci PG, D'Adamio L
J Biol Chem. 2002
PubMed ID: 11877420
Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.
Loukinova E, Ranganathan S, Kuznetsov S, Gorlatova N, Migliorini MM, Loukinov D, Ulery PG, Mikhailenko I, Lawrence DA, Strickland DK
J Biol Chem. 2002
PubMed ID: 11854294
Phosphorylation of LRP1: regulation of transport and signal transduction.
van der Geer P
Trends Cardiovasc Med. 2002
PubMed ID: 12069755
Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples.
Hecker TP, Grammer JR, Gillespie GY, Stewart J, Gladson CL
Cancer Res. 2002
PubMed ID: 11980671
Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement.
Saci A, Liu WQ, Vidal M, Garbay C, Rendu F, Bachelot-Loza C
Biochem J. 2002
PubMed ID: 11964172
Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling.
Liang X, Wisniewski D, Strife A, Shivakrupa, Clarkson B, Resh MD
J Biol Chem. 2002
PubMed ID: 11825908
Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling.
Zanetti A, Lampugnani MG, Balconi G, Breviario F, Corada M, Lanfrancone L, Dejana E
Arterioscler Thromb Vasc Biol. 2002
PubMed ID: 11950700
Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA.
Kisielow M, Kleiner S, Nagasawa M, Faisal A, Nagamine Y
Biochem J. 2002
PubMed ID: 11903040
Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling.
Ugi S, Imamura T, Ricketts W, Olefsky JM
Mol Cell Biol. 2002
PubMed ID: 11884620
Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway.
Nemoto S, Finkel T
Science. 2002
PubMed ID: 11884717
Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis.
Saucier C, Papavasiliou V, Palazzo A, Naujokas MA, Kremer R, Park M
Oncogene. 2002
PubMed ID: 11896612
Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin.
Bonvini P, Gastaldi T, Falini B, Rosolen A
Cancer Res. 2002
PubMed ID: 11888936
Phosphorylation of the N-terminal and C-terminal CD3-epsilon-ITAM tyrosines is differentially regulated in T cells.
Guirado M, de Aós I, Orta T, Rivas L, Terhorst C, Zubiaur M, Sancho J
Biochem Biophys Res Commun. 2002
PubMed ID: 11855827
PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.
Lynch DK, Daly RJ
EMBO J. 2002
PubMed ID: 11782427
Shc and CEACAM1 interact to regulate the mitogenic action of insulin.
Poy MN, Ruch RJ, Fernstrom MA, Okabayashi Y, Najjar SM
J Biol Chem. 2002
PubMed ID: 11694516
Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation.
Song RX, McPherson RA, Adam L, Bao Y, Shupnik M, Kumar R, Santen RJ
Mol Endocrinol. 2002
PubMed ID: 11773443
Identification and functional characterization of the p66/p68 components of the MeCP1 complex.
Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y
Mol Cell Biol. 2002
PubMed ID: 11756549
Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins.
Sotgia F, Lee H, Bedford MT, Petrucci T, Sudol M, Lisanti MP
Biochemistry. 2001
PubMed ID: 11724572
Effects of age on elements of insulin-signaling pathway in central nervous system of rats.
Fernandes ML, Saad MJ, Velloso LA
Endocrine. 2001
PubMed ID: 11954667
Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation.
Kashiwada M, Giallourakis CC, Pan PY, Rothman PB
J Immunol. 2001
PubMed ID: 11714803
ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen.
Nicholson PR, Empereur S, Glover HR, Dilworth SM
EMBO J. 2001
PubMed ID: 11707405
ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.
Ong SH, Dilworth S, Hauck-Schmalenberger I, Pawson T, Kiefer F
EMBO J. 2001
PubMed ID: 11707404
Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family.
Michel F, Soler-Lopez M, Petosa C, Cramer P, Siebenlist U, Müller CW
EMBO J. 2001
PubMed ID: 11707390
[A variety of functions of conventional and neuronal Shc adapter molecules in phosphotyrosine-mediated signalings]
Nakamura T, Mori N
Seikagaku. 2001
PubMed ID: 11831027
Signaling via Shc family adapter proteins.
Ravichandran KS
Oncogene. 2001
PubMed ID: 11607835
Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2.
Wheeler M, Domin J
Mol Cell Biol. 2001
PubMed ID: 11533253
The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells.
Pesesse X, Dewaste V, De Smedt F, Laffargue M, Giuriato S, Moreau C, Payrastre B, Erneux C
J Biol Chem. 2001
PubMed ID: 11349134
Endothelin-1 induces serine phosphorylation of the adaptor protein p66Shc and its association with 14-3-3 protein in glomerular mesangial cells.
Foschi M, Franchi F, Han J, La Villa G, Sorokin A
J Biol Chem. 2001
PubMed ID: 11342545
PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates.
Davidson D, Veillette A
EMBO J. 2001
PubMed ID: 11432829
Inhibition of insulin-like growth factor-I signaling by ethanol in neuronal cells.
Hallak H, Seiler AE, Green JS, Henderson A, Ross BN, Rubin R
Alcohol Clin Exp Res. 2001
PubMed ID: 11505033
Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: specific association of p68-Sck/ShcB with pp135.
Kojima T, Yoshikawa Y, Takada S, Sato M, Nakamura T, Takahashi N, Copeland NG, Gilbert DJ, Jenkins NA, Mori N
Biochem Biophys Res Commun. 2001
PubMed ID: 11409899
Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase.
Liu Y, Jenkins B, Shin JL, Rohrschneider LR
Mol Cell Biol. 2001
PubMed ID: 11287610
Shc mediates ligand-induced internalization of epidermal growth factor receptors.
Sakaguchi K, Okabayashi Y, Kasuga M
Biochem Biophys Res Commun. 2001
PubMed ID: 11302736
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes.
Dans M, Gagnoux-Palacios L, Blaikie P, Klein S, Mariotti A, Giancotti FG
J Biol Chem. 2001
PubMed ID: 11044453
Nerve growth factor signaling, neuroprotection, and neural repair.
Sofroniew MV, Howe CL, Mobley WC
Annu Rev Neurosci. 2001
PubMed ID: 11520933
The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons.
Sakai R, Henderson JT, O'Bryan JP, Elia AJ, Saxton TM, Pawson T
Neuron. 2000
PubMed ID: 11163269
Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.
Zeng L, Sachdev P, Yan L, Chan JL, Trenkle T, McClelland M, Welsh J, Wang LH
Mol Cell Biol. 2000
PubMed ID: 11094073
Evolution of Shc functions from nematode to human.
Luzi L, Confalonieri S, Di Fiore PP, Pelicci PG
Curr Opin Genet Dev. 2000
PubMed ID: 11088019
Identification of shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta 3 during outside-in integrin platelet signaling.
Cowan KJ, Law DA, Phillips DR
J Biol Chem. 2000
PubMed ID: 10964917
Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells.
van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M
Blood. 2000
PubMed ID: 11071635
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor.
Imokawa G, Kobayasi T, Miyagishi M
J Biol Chem. 2000
PubMed ID: 10921922
Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase.
Zhang S, Broxmeyer HE
Biochem Biophys Res Commun. 2000
PubMed ID: 11027663
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
p135 src homology 2 domain-containing inositol 5'-phosphatase (SHIPbeta ) isoform can substitute for p145 SHIP in fcgamma RIIB1-mediated inhibitory signaling in B cells.
March ME, Lucas DM, Aman MJ, Ravichandran KS
J Biol Chem. 2000
PubMed ID: 10900203
Adaptor protein Shc undergoes translocation and mediates up-regulation of the tyrosine kinase c-Src in EGF-stimulated A431 cells.
Sato K, Kimoto M, Kakumoto M, Horiuchi D, Iwasaki T, Tokmakov AA, Fukami Y
Genes Cells. 2000
PubMed ID: 10971656
Growth hormone (GH) induces the formation of protein complexes involving Stat5, Erk2, Shc and serine phosphorylated proteins.
Dinerstein-Cali H, Ferrag F, Kayser C, Kelly PA, Postel-Vinay M
Mol Cell Endocrinol. 2000
PubMed ID: 10996427
The functional significance of Shc in insulin signaling as a substrate of the insulin receptor.
Sasaoka T, Kobayashi M
Endocr J. 2000
PubMed ID: 11075717
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells.
Schaak S, Cussac D, Cayla C, Devedjian JC, Guyot R, Paris H, Denis C
Gut. 2000
PubMed ID: 10896916
Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells.
Nakajima K, Yamauchi K, Shigematsu S, Ikeo S, Komatsu M, Aizawa T, Hashizume K
J Biol Chem. 2000
PubMed ID: 10764799
The shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3.
Velazquez L, Gish GD, van Der Geer P, Taylor L, Shulman J, Pawson T
Blood. 2000
PubMed ID: 10891441
Ligand discrimination in signaling through an ErbB4 receptor homodimer.
Sweeney C, Lai C, Riese DJ, Diamonti AJ, Cantley LC, Carraway KL
J Biol Chem. 2000
PubMed ID: 10867024
CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
Poe JC, Fujimoto M, Jansen PJ, Miller AS, Tedder TF
J Biol Chem. 2000
PubMed ID: 10748054
The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase.
Slack BE
Biochem J. 2000
PubMed ID: 10816433
The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells.
Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD
Cell Signal. 2000
PubMed ID: 10822173
The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo.
Lai KM, Pawson T
Genes Dev. 2000
PubMed ID: 10809671
The real Dorian Gray mouse.
Lithgow GJ, Andersen JK
Bioessays. 2000
PubMed ID: 10797480
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.
Brdicka T, Pavlistová D, Leo A, Bruyns E, Korínek V, Angelisová P, Scherer J, Shevchenko A, Hilgert I, Cerný J, Drbal K, Kuramitsu Y, Kornacker B, Horejsí V, Schraven B
J Exp Med. 2000
PubMed ID: 10790433
Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors.
Foehr ED, Tatavos A, Tanabe E, Raffioni S, Goetz S, Dimarco E, De Luca M, Bradshaw RA
FASEB J. 2000
PubMed ID: 10783152
The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells.
Warner AJ, Lopez-Dee J, Knight EL, Feramisco JR, Prigent SA
Biochem J. 2000
PubMed ID: 10749680
Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2.
Kasus-Jacobi A, Béréziat V, Perdereau D, Girard J, Burnol AF
Oncogene. 2000
PubMed ID: 10803466
Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop.
Koch A, Mancini A, Stefan M, Niedenthal R, Niemann H, Tamura T
FEBS Lett. 2000
PubMed ID: 10708759
Shc associates with the IL-3 receptor beta subunit, SHIP and Gab2 following IL-3 stimulation. Contribution of Shc PTB and SH2 domains.
Bone H, Welham MJ
Cell Signal. 2000
PubMed ID: 10704825
Discoidin domain receptor 1 is activated independently of beta(1) integrin.
Vogel W, Brakebusch C, Fässler R, Alves F, Ruggiero F, Pawson T
J Biol Chem. 2000
PubMed ID: 10681566
The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties.
Qian X, Esteban L, Vass WC, Upadhyaya C, Papageorge AG, Yienger K, Ward JM, Lowy DR, Santos E
EMBO J. 2000
PubMed ID: 10675333
The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells.
Eckenberg R, Rose T, Moreau JL, Weil R, Gesbert F, Dubois S, Tello D, Bossus M, Gras H, Tartar A, Bertoglio J, Chouaïb S, Goldberg M, Jacques Y, Alzari PM, Thèze J
J Exp Med. 2000
PubMed ID: 10662798
Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line.
Ikizawa K, Yanagihara Y
Biochem Biophys Res Commun. 2000
PubMed ID: 10652211
Potential involvement of FRS2 in insulin signaling.
Delahaye L, Rocchi S, Van Obberghen E
Endocrinology. 2000
PubMed ID: 10650943
FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.
Ong SH, Guy GR, Hadari YR, Laks S, Gotoh N, Schlessinger J, Lax I
Mol Cell Biol. 2000
PubMed ID: 10629055
Activation of human neutrophils by Mycobacterium tuberculosis H37Ra involves phospholipase C gamma 2, Shc adapter protein, and p38 mitogen-activated protein kinase.
Perskvist N, Zheng L, Stendahl O
J Immunol. 2000
PubMed ID: 10623845
Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain.
Delespine-Carmagnat M, Bouvier G, Bertoglio J
Eur J Immunol. 2000
PubMed ID: 10602027
High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase.
Park RK, Erdreich-Epstein A, Liu M, Izadi KD, Durden DL
J Immunol. 1999
PubMed ID: 10570290
Tyrosine phosphorylation of caldesmon is required for binding to the Shc.Grb2 complex.
Wang Z, Danielsen AJ, Maihle NJ, McManus MJ
J Biol Chem. 1999
PubMed ID: 10559276
The p66shc adaptor protein controls oxidative stress response and life span in mammals.
Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG
Nature. 1999
PubMed ID: 10580504
Insulin-induced tyrosine phosphorylation of Shc in liver, muscle and adipose tissue of insulin resistant rats.
Páez-Espinosa EV, Rocha EM, Velloso LA, Boschero AC, Saad MJ
Mol Cell Endocrinol. 1999
PubMed ID: 10612430
Role of Src in the modulation of multiple adaptor proteins in FcalphaRI oxidant signaling.
Park RK, Izadi KD, Deo YM, Durden DL
Blood. 1999
PubMed ID: 10477741
Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF.
Stomski FC, Dottore M, Winnall W, Guthridge MA, Woodcock J, Bagley CJ, Thomas DT, Andrews RK, Berndt MC, Lopez AF
Blood. 1999
PubMed ID: 10477722
SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor.
Marchetto S, Fournier E, Beslu N, Aurran-Schleinitz T, Dubreuil P, Borg JP, Birnbaum D, Rosnet O
Leukemia. 1999
PubMed ID: 10482988
The human high-affinity immunoglobulin G receptor activates SH2-containing inositol phosphatase (SHIP).
Cameron AJ, Allen JM
Immunology. 1999
PubMed ID: 10457218
Fcgamma receptor-mediated inhibition of human B cell activation: the role of SHP-2 phosphatase.
Koncz G, Pecht I, Gergely J, Sármay G
Eur J Immunol. 1999
PubMed ID: 10382761
Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site.
van der Geer P, Wiley S, Pawson T
Oncogene. 1999
PubMed ID: 10340378
Thrombopoietin signal transduction requires functional JAK2, not TYK2.
Drachman JG, Millett KM, Kaushansky K
J Biol Chem. 1999
PubMed ID: 10224114
16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells.
D'Angelo G, Martini JF, Iiri T, Fantl WJ, Martial J, Weiner RI
Mol Endocrinol. 1999
PubMed ID: 10319320
A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells.
Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh WM, Tempst P, Clarkson B
Blood. 1999
PubMed ID: 10194451
The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation.
Meakin SO, MacDonald JI, Gryz EA, Kubu CJ, Verdi JM
J Biol Chem. 1999
PubMed ID: 10092678
A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling.
Wong L, Deb TB, Thompson SA, Wells A, Johnson GR
J Biol Chem. 1999
PubMed ID: 10085134
A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development.
Lucas DM, Rohrschneider LR
Blood. 1999
PubMed ID: 10068665
Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells.
Schmandt R, Liu SK, McGlade CJ
Oncogene. 1999
PubMed ID: 10086341
Phosphotyrosine binding domains of Shc and insulin receptor substrate 1 recognize the NPXpY motif in a thermodynamically distinct manner.
Farooq A, Plotnikova O, Zeng L, Zhou MM
J Biol Chem. 1999
PubMed ID: 10037694
Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells.
Zhang S, Mantel C, Broxmeyer HE
J Leukoc Biol. 1999
PubMed ID: 10080542
Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle.
Kim YB, Inoue T, Nakajima R, Shirai-Morishita Y, Tokuyama K, Suzuki M
Biochem Biophys Res Commun. 1999
PubMed ID: 9920808
Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling.
Fournier E, Blaikie P, Rosnet O, Margolis B, Birnbaum D, Borg JP
Oncogene. 1999
PubMed ID: 9927207
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc.
Liu SK, McGlade CJ
Oncogene. 1998
PubMed ID: 9872323
Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).
Zhu T, Goh EL, LeRoith D, Lobie PE
J Biol Chem. 1998
PubMed ID: 9837978
Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation.
Gu H, Pratt JC, Burakoff SJ, Neel BG
Mol Cell. 1998
PubMed ID: 9885561
Role of SHIP in FcgammaRIIb-mediated inhibition of Ras activation in B cells.
Tridandapani S, Phee H, Shivakumar L, Kelley TW, Coggeshall KM
Mol Immunol. 1998
PubMed ID: 10395202
Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor.
Ward AC, Monkhouse JL, Hamilton JA, Csar XF
Biochim Biophys Acta. 1998
PubMed ID: 9824671
Identification and characterization of novel substrates of Trk receptors in developing neurons.
Qian X, Riccio A, Zhang Y, Ginty DD
Neuron. 1998
PubMed ID: 9856458
Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration.
Sieg DJ, Ilić D, Jones KC, Damsky CH, Hunter T, Schlaepfer DD
EMBO J. 1998
PubMed ID: 9774338
Identification of the rat adapter Grb14 as an inhibitor of insulin actions.
Kasus-Jacobi A, Perdereau D, Auzan C, Clauser E, Van Obberghen E, Mauvais-Jarvis F, Girard J, Burnol AF
J Biol Chem. 1998
PubMed ID: 9748281
Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor.
Pomérance M, Multon MC, Parker F, Venot C, Blondeau JP, Tocqué B, Schweighoffer F
J Biol Chem. 1998
PubMed ID: 9733714
A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth.
Wary KK, Mariotti A, Zurzolo C, Giancotti FG
Cell. 1998
PubMed ID: 9741627
SLP-76-Cbl-Grb2-Shc interactions in FcgammaRI signaling.
Chu J, Liu Y, Koretzky GA, Durden DL
Blood. 1998
PubMed ID: 9716598
ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner.
Olayioye MA, Graus-Porta D, Beerli RR, Rohrer J, Gay B, Hynes NE
Mol Cell Biol. 1998
PubMed ID: 9710588
Mutation of a Shc binding site tyrosine residue in ErbB3/HER3 blocks heregulin-dependent activation of mitogen-activated protein kinase.
Vijapurkar U, Cheng K, Koland JG
J Biol Chem. 1998
PubMed ID: 9694850
Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation.
Pacini S, Ulivieri C, Di Somma MM, Isacchi A, Lanfrancone L, Pelicci PG, Telford JL, Baldari CT
J Biol Chem. 1998
PubMed ID: 9685404
Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc.
Walk SF, March ME, Ravichandran KS
Eur J Immunol. 1998
PubMed ID: 9710204
The structural basis of the activation of Ras by Sos.
Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J
Nature. 1998
PubMed ID: 9690470
Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein.
Habib T, Hejna JA, Moses RE, Decker SJ
J Biol Chem. 1998
PubMed ID: 9660833
Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways.
Liang Q, Mohan RR, Chen L, Wilson SE
Invest Ophthalmol Vis Sci. 1998
PubMed ID: 9660480
Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins.
Moutoussamy S, Renaudie F, Lago F, Kelly PA, Finidori J
J Biol Chem. 1998
PubMed ID: 9632636
The CBL-related protein CBLB participates in FLT3 and interleukin-7 receptor signal transduction in pro-B cells.
Lavagna-Sévenier C, Marchetto S, Birnbaum D, Rosnet O
J Biol Chem. 1998
PubMed ID: 9614102
Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events.
Schlaepfer DD, Jones KC, Hunter T
Mol Cell Biol. 1998
PubMed ID: 9566877
Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction.
McCarty JH, Feinstein SC
Oncogene. 1998
PubMed ID: 9582017
Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells.
Sakaguchi K, Okabayashi Y, Kido Y, Kimura S, Matsumura Y, Inushima K, Kasuga M
Mol Endocrinol. 1998
PubMed ID: 9544989
Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.
Tiganis T, Bennett AM, Ravichandran KS, Tonks NK
Mol Cell Biol. 1998
PubMed ID: 9488479
Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells.
Gesbert F, Garbay C, Bertoglio J
J Biol Chem. 1998
PubMed ID: 9461587
Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C.
Soltoff SP, Avraham H, Avraham S, Cantley LC
J Biol Chem. 1998
PubMed ID: 9446569
The discoidin domain receptor tyrosine kinases are activated by collagen.
Vogel W, Gish GD, Alves F, Pawson T
Mol Cell. 1997
PubMed ID: 9659899
Tyrosine residues 239 and 240 of Shc are phosphatidylinositol 4,5-bisphosphate-dependent phosphorylation sites by c-Src.
Sato K, Gotoh N, Otsuki T, Kakumoto M, Aoto M, Tokmakov AA, Shibuya M, Fukami Y
Biochem Biophys Res Commun. 1997
PubMed ID: 9388490
The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway.
Okada S, Kao AW, Ceresa BP, Blaikie P, Margolis B, Pessin JE
J Biol Chem. 1997
PubMed ID: 9346957
SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1.
Anafi M, Kiefer F, Gish GD, Mbamalu G, Iscove NN, Pawson T
J Biol Chem. 1997
PubMed ID: 9346925
Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
Gene. 1997
PubMed ID: 9373149
Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells.
Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O
Biochem Biophys Res Commun. 1997
PubMed ID: 9344843
Selective binding of shc-SH2 domain to tyrosine-phosphorylated zeta but not gamma-chain upon CD16 ligation on human NK cells.
Galandrini R, Palmieri G, Paolini R, Piccoli M, Frati L, Santoni A
J Immunol. 1997
PubMed ID: 9378963
Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum.
Menegon A, Leoni C, Benfenati F, Valtorta F
Biochem Biophys Res Commun. 1997
PubMed ID: 9325171
Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation.
Dankort DL, Wang Z, Blackmore V, Moran MF, Muller WJ
Mol Cell Biol. 1997
PubMed ID: 9271418
Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity.
Bonita DP, Miyake S, Lupher ML, Langdon WY, Band H
Mol Cell Biol. 1997
PubMed ID: 9234717
Evidence for a direct interaction between insulin receptor substrate-1 and Shc.
Kasus-Jacobi A, Perdereau D, Tartare-Deckert S, Van Obberghen E, Girard J, Burnol AF
J Biol Chem. 1997
PubMed ID: 9202037
Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation.
Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A
Oncogene. 1997
PubMed ID: 9233773
The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.
Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H
Oncogene. 1997
PubMed ID: 9223670
Characterization of human SHC p66 cDNA and its processed pseudogene mapping to Xq12-q13.1.
Harun RB, Smith KK, Leek JP, Markham AF, Norris A, Morrison JF
Genomics. 1997
PubMed ID: 9192859
Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways.
Kao AW, Waters SB, Okada S, Pessin JE
Endocrinology. 1997
PubMed ID: 9165038
Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src.
Schlaepfer DD, Hunter T
J Biol Chem. 1997
PubMed ID: 9148935
ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
Morris SW, Naeve C, Mathew P, James PL, Kirstein MN, Cui X, Witte DP
Oncogene. 1997
PubMed ID: 9174053
Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase.
Giordano V, De Falco G, Chiari R, Quinto I, Pelicci PG, Bartholomew L, Delmastro P, Gadina M, Scala G
J Immunol. 1997
PubMed ID: 9126968
Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP.
Lamkin TD, Walk SF, Liu L, Damen JE, Krystal G, Ravichandran KS
J Biol Chem. 1997
PubMed ID: 9099679
Functional importance of Shc tyrosine 317 on insulin signaling in Rat1 fibroblasts expressing insulin receptors.
Ishihara H, Sasaoka T, Ishiki M, Takata Y, Imamura T, Usui I, Langlois WJ, Sawa T, Kobayashi M
J Biol Chem. 1997
PubMed ID: 9083103
The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis.
Liu L, Damen JE, Hughes MR, Babic I, Jirik FR, Krystal G
J Biol Chem. 1997
PubMed ID: 9083021
P210 Bcr-Abl interacts with the interleukin-3 beta c subunit and constitutively activates Jak2.
Wilson-Rawls J, Liu J, Laneuville P, Arlinghaus RB
Leukemia. 1997
PubMed ID: 9209414
Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation.
Gotoh N, Toyoda M, Shibuya M
Mol Cell Biol. 1997
PubMed ID: 9121430
Antisense src expression inhibits tyrosine phosphorylation of Shc and its association with Grb2 and Sos which leads to MAP kinase activation in U937 human leukemia cells.
Yamaguchi M, Tanaka T, Waki M, Kitanaka A, Kamano H, Kubota Y, Ohnishi H, Takahara J, Irino S
Leukemia. 1997
PubMed ID: 9096689
Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain.
Drachman JG, Kaushansky K
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9122198
A tyrosine-phosphorylated protein of 140 kD is constitutively associated with the phosphotyrosine binding domain of Shc and the SH3 domains of Grb2 in acute myeloid leukemia cells.
Jücker M, Schiffer CA, Feldman RA
Blood. 1997
PubMed ID: 9058724
Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.
Kanai M, Göke M, Tsunekawa S, Podolsky DK
J Biol Chem. 1997
PubMed ID: 9045692
Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins.
Zambrano N, Buxbaum JD, Minopoli G, Fiore F, De Candia P, De Renzis S, Faraonio R, Sabo S, Cheetham J, Sudol M, Russo T
J Biol Chem. 1997
PubMed ID: 9045663
Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.
Price DJ, Rivnay B, Fu Y, Jiang S, Avraham S, Avraham H
J Biol Chem. 1997
PubMed ID: 9038210
Identification of Shc docking site on Ret tyrosine kinase.
Arighi E, Alberti L, Torriti F, Ghizzoni S, Rizzetti MG, Pelicci G, Pasini B, Bongarzone I, Piutti C, Pierotti MA, Borrello MG
Oncogene. 1997
PubMed ID: 9047384
RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2.
Lorenzo MJ, Gish GD, Houghton C, Stonehouse TJ, Pawson T, Ponder BA, Smith DP
Oncogene. 1997
PubMed ID: 9047383
Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.
Migliaccio E, Mele S, Salcini AE, Pelicci G, Lai KM, Superti-Furga G, Pawson T, Di Fiore PP, Lanfrancone L, Pelicci PG
EMBO J. 1997
PubMed ID: 9049300
The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling.
Trüb T, Frantz JD, Miyazaki M, Band H, Shoelson SE
J Biol Chem. 1997
PubMed ID: 8995379
Characterization of the phosphotyrosine-binding domain of the Drosophila Shc protein.
Li SC, Lai KM, Gish GD, Parris WE, van der Geer P, Forman-Kay J, Pawson T
J Biol Chem. 1996
PubMed ID: 8943228
Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors.
Yokote K, Margolis B, Heldin CH, Claesson-Welsh L
J Biol Chem. 1996
PubMed ID: 8940081
Human type II Fcgamma receptors inhibit B cell activation by interacting with the p21(ras)-dependent pathway.
Sármay G, Koncz G, Gergely J
J Biol Chem. 1996
PubMed ID: 8940017
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2.
Chook YM, Gish GD, Kay CM, Pai EF, Pawson T
J Biol Chem. 1996
PubMed ID: 8940013
The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions.
van der Geer P, Wiley S, Gish GD, Pawson T
Curr Biol. 1996
PubMed ID: 8939605
STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family.
Iwama A, Yamaguchi N, Suda T
EMBO J. 1996
PubMed ID: 8918464
Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor.
Kimura T, Kihara H, Bhattacharyya S, Sakamoto H, Appella E, Siraganian RP
J Biol Chem. 1996
PubMed ID: 8910399
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.
Borg JP, Ooi J, Levy E, Margolis B
Mol Cell Biol. 1996
PubMed ID: 8887653
Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation.
Ware MD, Rosten P, Damen JE, Liu L, Humphries RK, Krystal G
Blood. 1996
PubMed ID: 8874179
Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor.
Okada S, Pessin JE
J Biol Chem. 1996
PubMed ID: 8810325
Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways.
Roche S, McGlade J, Jones M, Gish GD, Pawson T, Courtneidge SA
EMBO J. 1996
PubMed ID: 8890167
Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner.
Sasaoka T, Ishihara H, Sawa T, Ishiki M, Morioka H, Imamura T, Usui I, Takata Y, Kobayashi M
J Biol Chem. 1996
PubMed ID: 8702728
The aminoterminal phosphotyrosine binding domain of Shc associates with ZAP-70 and mediates TCR dependent gene activation.
Milia E, Di Somma MM, Baldoni F, Chiari R, Lanfrancone L, Pelicci PG, Telford JL, Baldari CT
Oncogene. 1996
PubMed ID: 8761298
Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins.
Fukazawa T, Miyake S, Band V, Band H
J Biol Chem. 1996
PubMed ID: 8662998
Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10.
Dey BR, Frick K, Lopaczynski W, Nissley SP, Furlanetto RW
Mol Endocrinol. 1996
PubMed ID: 8776723
Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase.
Fournier E, Rosnet O, Marchetto S, Turck CW, Rottapel R, Pelicci PG, Birnbaum D, Borg JP
J Biol Chem. 1996
PubMed ID: 8662748
Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein.
Fixman ED, Fournier TM, Kamikura DM, Naujokas MA, Park M
J Biol Chem. 1996
PubMed ID: 8662733
Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling.
Ravichandran KS, Igras V, Shoelson SE, Fesik SW, Burakoff SJ
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8643566
Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation.
Satoh T, Kato J, Nishida K, Kaziro Y
FEBS Lett. 1996
PubMed ID: 8647288
Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation.
Law DA, Nannizzi-Alaimo L, Phillips DR
J Biol Chem. 1996
PubMed ID: 8631894
Binding affinities of the SH2 domains of ZAP-70, p56lck and Shc to the zeta chain ITAMs of the T-cell receptor determined by surface plasmon resonance.
Labadia ME, Ingraham RH, Schembri-King J, Morelock MM, Jakes S
J Leukoc Biol. 1996
PubMed ID: 8656061
p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.
Lioubin MN, Algate PA, Tsai S, Carlberg K, Aebersold A, Rohrschneider LR
Genes Dev. 1996
PubMed ID: 8654924
Sch proteins are localized on endoplasmic reticulum membranes and are redistributed after tyrosine kinase receptor activation.
Lotti LV, Lanfrancone L, Migliaccio E, Zompetta C, Pelicci G, Salcini AE, Falini B, Pelicci PG, Torrisi MR
Mol Cell Biol. 1996
PubMed ID: 8628261
Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5).
Fujimoto J, Shiota M, Iwahara T, Seki N, Satoh H, Mori S, Yamamoto T
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8633037
Phosphotyrosine-independent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST. Evidence for extended phosphotyrosine binding/phosphotyrosine interaction domain recognition specificity.
Charest A, Wagner J, Jacob S, McGlade CJ, Tremblay ML
J Biol Chem. 1996
PubMed ID: 8626541
A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain.
O'Bryan JP, Songyang Z, Cantley L, Der CJ, Pawson T
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8610109
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.
Kavanaugh WM, Pot DA, Chin SM, Deuter-Reinhard M, Jefferson AB, Norris FA, Masiarz FR, Cousens LS, Majerus PW, Williams LT
Curr Biol. 1996
PubMed ID: 8723348
Interaction of Shc with adaptor protein adaptins.
Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M
J Biol Chem. 1996
PubMed ID: 8617812
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.
Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8643691
The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes.
Sadoshima J, Izumo S
EMBO J. 1996
PubMed ID: 8631299
p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase.
Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H
J Biol Chem. 1996
PubMed ID: 8621719
Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.
van der Geer P, Wiley S, Gish GD, Lai VK, Stephens R, White MF, Kaplan D, Pawson T
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8577769
Activation-induced association of a 145-kDa tyrosine-phosphorylated protein with Shc and Syk in B lymphocytes and macrophages.
Crowley MT, Harmer SL, DeFranco AL
J Biol Chem. 1996
PubMed ID: 8557643
Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase.
Fridell YW, Jin Y, Quilliam LA, Burchert A, McCloskey P, Spizz G, Varnum B, Der C, Liu ET
Mol Cell Biol. 1996
PubMed ID: 8524290
Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells.
Mu SX, Xia M, Elliott G, Bogenberger J, Swift S, Bennett L, Lappinga DL, Hecht R, Lee R, Saris CJ
Blood. 1995
PubMed ID: 8541543
Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Zhou MM, Ravichandran KS, Olejniczak EF, Petros AM, Meadows RP, Sattler M, Harlan JE, Wade WS, Burakoff SJ, Fesik SW
Nature. 1995
PubMed ID: 8524391
PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.
Wolf G, Trüb T, Ottinger E, Groninga L, Lynch A, White MF, Miyazaki M, Lee J, Shoelson SE
J Biol Chem. 1995
PubMed ID: 7499194
Crystal structure of the SH2 domain from the adaptor protein SHC: a model for peptide binding based on X-ray and NMR data.
Mikol V, Baumann G, Zurini MG, Hommel U
J Mol Biol. 1995
PubMed ID: 7473762
Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system.
Tartare-Deckert S, Sawka-Verhelle D, Murdaca J, Van Obberghen E
J Biol Chem. 1995
PubMed ID: 7559507
Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.
He W, O'Neill TJ, Gustafson TA
J Biol Chem. 1995
PubMed ID: 7559478
Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes.
Mainiero F, Pepe A, Wary KK, Spinardi L, Mohammadi M, Schlessinger J, Giancotti FG
EMBO J. 1995
PubMed ID: 7556090
Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor.
Fournier E, Dubreuil P, Birnbaum D, Borg JP
Oncogene. 1995
PubMed ID: 7675451
Naturally occurring tyrosine kinase inserts block high affinity binding of phospholipase C gamma and Shc to TrkC and neurotrophin-3 signaling.
Guiton M, Gunn-Moore FJ, Glass DJ, Geis DR, Yancopoulos GD, Tavaré JM
J Biol Chem. 1995
PubMed ID: 7657612
Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.
Lev S, Moreno H, Martinez R, Canoll P, Peles E, Musacchio JM, Plowman GD, Rudy B, Schlessinger J
Nature. 1995
PubMed ID: 7544443
G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase.Shc adapter protein signaling complexes.
Ptasznik A, Traynor-Kaplan A, Bokoch GM
J Biol Chem. 1995
PubMed ID: 7650013
Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
Zhou MM, Meadows RP, Logan TM, Yoon HS, Wade WS, Ravichandran KS, Burakoff SJ, Fesik SW
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7544002
A human SHC-related sequence maps to chromosome 17, the SHC gene maps to chromosome 1.
Yulug IG, Egan SE, See CG, Fisher EM
Hum Genet. 1995
PubMed ID: 7635484
Constitutive phosphorylation of eps8 in tumor cell lines: relevance to malignant transformation.
Matoskova B, Wong WT, Salcini AE, Pelicci PG, Di Fiore PP
Mol Cell Biol. 1995
PubMed ID: 7791787
Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.
Craparo A, O'Neill TJ, Gustafson TA
J Biol Chem. 1995
PubMed ID: 7541045
Shc binding to nerve growth factor receptor is mediated by the phosphotyrosine interaction domain.
Dikic I, Batzer AG, Blaikie P, Obermeier A, Ullrich A, Schlessinger J, Margolis B
J Biol Chem. 1995
PubMed ID: 7541035
Insulin-stimulated disassociation of the SOS-Grb2 complex.
Waters SB, Yamauchi K, Pessin JE
Mol Cell Biol. 1995
PubMed ID: 7739560
Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain.
Gustafson TA, He W, Craparo A, Schaub CD, O'Neill TJ
Mol Cell Biol. 1995
PubMed ID: 7537849
The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein.
Pelicci G, Giordano S, Zhen Z, Salcini AE, Lanfrancone L, Bardelli A, Panayotou G, Waterfield MD, Ponzetto C, Pelicci PG
Oncogene. 1995
PubMed ID: 7731718
Association of phosphatidylinositol 3-kinase with SHC in chronic myelogeneous leukemia cells.
Harrison-Findik D, Susa M, Varticovski L
Oncogene. 1995
PubMed ID: 7537361
A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides.
van der Geer P, Wiley S, Lai VK, Olivier JP, Gish GD, Stephens R, Kaplan D, Shoelson S, Pawson T
Curr Biol. 1995
PubMed ID: 7542991
Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2.
VanderKuur J, Allevato G, Billestrup N, Norstedt G, Carter-Su C
J Biol Chem. 1995
PubMed ID: 7535773
The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.
Sasaoka T, Langlois WJ, Leitner JW, Draznin B, Olefsky JM
J Biol Chem. 1994
PubMed ID: 7798267
A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.
Blaikie P, Immanuel D, Wu J, Li N, Yajnik V, Margolis B
J Biol Chem. 1994
PubMed ID: 7798194
Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors.
Pajusola K, Aprelikova O, Pelicci G, Weich H, Claesson-Welsh L, Alitalo K
Oncogene. 1994
PubMed ID: 7970715
Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70.
Watts JD, Affolter M, Krebs DL, Wange RL, Samelson LE, Aebersold R
J Biol Chem. 1994
PubMed ID: 7961936
Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1.
Sif S, Gilmore TD
J Virol. 1994
PubMed ID: 7933095
Activators of protein kinase C stimulate association of Shc and the PEST tyrosine phosphatase.
Habib T, Herrera R, Decker SJ
J Biol Chem. 1994
PubMed ID: 7929214
Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositol.
Lazar DF, Knez JJ, Medof ME, Cuatrecasas P, Saltiel AR
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7524086
Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins.
Salcini AE, McGlade J, Pelicci G, Nicoletti I, Pawson T, Pelicci PG
Oncogene. 1994
PubMed ID: 8084588
Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells.
Lioubin MN, Myles GM, Carlberg K, Bowtell D, Rohrschneider LR
Mol Cell Biol. 1994
PubMed ID: 7520523
CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.
Matsuda M, Hashimoto Y, Muroya K, Hasegawa H, Kurata T, Tanaka S, Nakamura S, Hattori S
Mol Cell Biol. 1994
PubMed ID: 8035825
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.
Batzer AG, Rotin D, Ureña JM, Skolnik EY, Schlessinger J
Mol Cell Biol. 1994
PubMed ID: 7518560
Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2).
Huebner K, Kastury K, Druck T, Salcini AE, Lanfrancone L, Pelicci G, Lowenstein E, Li W, Park SH, Cannizzaro L
Genomics. 1994
PubMed ID: 7806213
Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains.
Weng Z, Thomas SM, Rickles RJ, Taylor JA, Brauer AW, Seidel-Dugan C, Michael WM, Dreyfuss G, Brugge JS
Mol Cell Biol. 1994
PubMed ID: 7516469
SH2 domain specificity and activity modified by a single residue.
Marengere LE, Songyang Z, Gish GD, Schaller MD, Parsons JT, Stern MJ, Cantley LC, Pawson T
Nature. 1994
PubMed ID: 7515480
The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins.
Borrello MG, Pelicci G, Arighi E, De Filippis L, Greco A, Bongarzone I, Rizzetti M, Pelicci PG, Pierotti MA
Oncogene. 1994
PubMed ID: 8183561
Direct interaction between Shc and the platelet-derived growth factor beta-receptor.
Yokote K, Mori S, Hansen K, McGlade J, Pawson T, Heldin CH, Claesson-Welsh L
J Biol Chem. 1994
PubMed ID: 8195171
Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells.
Spivak-Kroizman T, Mohammadi M, Hu P, Jaye M, Schlessinger J, Lax I
J Biol Chem. 1994
PubMed ID: 7514169
Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor.
Sasaoka T, Rose DW, Jhun BH, Saltiel AR, Draznin B, Olefsky JM
J Biol Chem. 1994
PubMed ID: 7513704
Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses.
Stephens RM, Loeb DM, Copeland TD, Pawson T, Greene LA, Kaplan DR
Neuron. 1994
PubMed ID: 8155326
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.
Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R, Pawson T
EMBO J. 1994
PubMed ID: 8112292
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
PubMed ID: 8125298
The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation.
Ravichandran KS, Burakoff SJ
J Biol Chem. 1994
PubMed ID: 8294403
Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex.
Obermeier A, Lammers R, Wiesmüller KH, Jung G, Schlessinger J, Ullrich A
J Biol Chem. 1993
PubMed ID: 8226808
Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein.
Damen JE, Liu L, Cutler RL, Krystal G
Blood. 1993
PubMed ID: 8400282
Shc products are substrates of erbB-2 kinase.
Segatto O, Pelicci G, Giuli S, Digiesi G, Di Fiore PP, McGlade J, Pawson T, Pelicci PG
Oncogene. 1993
PubMed ID: 8101647
The function of GRB2 in linking the insulin receptor to Ras signaling pathways.
Skolnik EY, Batzer A, Li N, Lee CH, Lowenstein E, Mohammadi M, Margolis B, Schlessinger J
Science. 1993
PubMed ID: 8316835
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D
Science. 1993
PubMed ID: 8493579
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.
Skolnik EY, Lee CH, Batzer A, Vicentini LM, Zhou M, Daly R, Myers MJ, Backer JM, Ullrich A, White MF
EMBO J. 1993
PubMed ID: 8491186
Epidermal growth factor stimulates the tyrosine phosphorylation of SHC in the mouse.
Ruff-Jamison S, McGlade J, Pawson T, Chen K, Cohen S
J Biol Chem. 1993
PubMed ID: 7681824
Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.
McGlade J, Cheng A, Pelicci G, Pelicci PG, Pawson T
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1409579
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG
Cell. 1992
PubMed ID: 1623525

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	6464	20416	85385
EnsEMBL Gene(s)	ENSG00000160691	ENSMUSG00000042626	ENSRNOG00000020657
Unigene	Hs.433795	Mm.86595	Rn.138818
Homologene	SHC1	Shc1	Shc1
OMIM	600560	N/A	N/A
GeneCards	SHC1	N/A	N/A
Beta Cell Genomics	DT.100846065 DT.121413736 DT.121413815 DT.121413963 DT.121413965 DT.40287869 DT.447555 DT.91775292 DT.91794052 DT.91850144 DT.95212663	DT.101180654 DT.101385146 DT.101385152 DT.110749809 DT.491522	N/A
Reactome	P29353	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	6464	20416	85385

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
SHC1	CDH5	HPRD, MINT, BioGRID	empirical	11950700
SHC1	CALCOCO2	HPRD, IntAct, BioGRID	empirical	16189514
SHC1	DNAJA2	IntAct	empirical	19380743
SHC1	VAV3	HPRD, BioGRID	empirical	11094073
SHC1	SH2B2	HPRD	empirical	9233773
SHC1	GRAP	HPRD	empirical	8995379
SHC1	C11orf58	BioGRID	empirical	21900206
SHC1	NUDT21	BioGRID	empirical	21900206
SHC1	MAP4K1	HPRD	empirical	9346925
SHC1	AP2M1	IntAct	empirical	19380743
SHC1	CRK	HPRD, IntAct	empirical	8035825 9461587 9837978 19380743
SHC1	CRKL	HPRD, BioGRID	empirical	9344843
SHC1	MAPK14	HPRD	empirical	15688026
SHC1	CSF1R	HPRD	empirical	7520523
SHC1	CSF2RB	HPRD, BioGRID	empirical	10704825 10477722
SHC1	CSF3R	HPRD, BioGRID	empirical	9824671 17001306
SHC1	CSK	HPRD, IntAct, BioGRID	empirical	12048194 10037694 19380743
SHC1	AP2A1	HPRD, IntAct	empirical	11302736 8617812 19380743
SHC1	DAG1	HPRD, BioGRID	empirical	11724572
SHC1	AP2A2	HPRD, IntAct, BioGRID	empirical	8617812 19380743
SHC1	AP2B1	IntAct	empirical	19380743
SHC1	DNM2	IntAct	empirical	19380743
SHC1	DOK1	HPRD, BioGRID	empirical	11071635 10822173
SHC1	EGFR	HPRD, MINT, IntAct, BioGRID	empirical	9544989 8887653 12577067 16729043 7518560 8662998 16273093 7798267 21278788 20935677 15657067 19531499
SHC1	EPHA2	HPRD, BioGRID	empirical	12400011
SHC1	EPOR	HPRD, BioGRID	empirical	8400282
SHC1	EPS8	HPRD, BioGRID	empirical	7791787
SHC1	ERBB2	HPRD, MINT, IntAct, BioGRID	empirical	9710588 16729043 16843263 16273093 10085134
SHC1	ERBB3	HPRD, MINT, BioGRID	empirical	9694850 16729043 16273093
SHC1	ERBB4	HPRD, MINT, BioGRID	empirical	16729043 16273093
SHC1	ESR1	HPRD, IntAct, BioGRID	empirical	11773443 20935677
SHC1	PTK2B	HPRD	empirical	7544443
SHC1	FCGR1A	MINT	empirical	9716598
SHC1	FCGR2A	HPRD	empirical	10382761 8940017
SHC1	FCGR2B	BioGRID	empirical	8940017
SHC1	FCGR3A	HPRD	empirical	9378963
SHC1	FLT1	HPRD, BioGRID	empirical	10749680
SHC1	FLT4	HPRD, BioGRID	empirical	7675451 8662748 9927207 7970715
SHC1	CBLC	BioGRID	empirical	21900206
SHC1	ALK	HPRD, BioGRID	empirical	9174053 11888936
SHC1	ABL1	BioGRID	empirical	10194451 8112292
SHC1	FYN	HPRD, MINT	empirical	7516469 12237775 11075717 10764799 9121430 9446569 10816433 10896916 10921922 9741627 9710204 10482988
SHC1	GAB1	HPRD, MINT	empirical	12808090 10871282
SHC1	AMD1	MINT, IntAct	empirical	15102471
SHC1	GH1	BioGRID	empirical	7535773
SHC1	GHR	HPRD, MINT, BioGRID	empirical	9632636 7535773
SHC1	GRB2	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	11707405 7524086 7535773 8491186 12485888 7798267 8621719 15688026 9733714 9544989 8940013 12577067 16520382 8662998 17673906 12446583 19380743 20697350 10748054 21706016 8112292 8647288 8662733 9083103 9927207 8294403 12441060 10477741 11302736 10570290 11505033 8195171 11964172 10080542 9045692 7514169 9126968 15812354 12167719
SHC1	GRB7	HPRD	empirical	8940081
SHC1	RAPGEF1	HPRD, BioGRID	empirical	9344843
SHC1	HIF1A	BioGRID	empirical	12114320
SHC1	HMOX2	BioGRID	empirical	21900206
SHC1	IGF1R	IntAct, BioGRID	empirical	7541045 15629149 8776723 16113100 7559507
SHC1	APP	HPRD, MINT, IntAct, BioGRID	empirical	11877420 9045663 12485888 17384289
SHC1	IL2	HPRD	empirical	10662798
SHC1	IL2RB	HPRD, BioGRID	empirical	10602027 8294403
SHC1	IL2RG	HPRD, BioGRID	empirical	8643566
SHC1	IL4R	HPRD, BioGRID	empirical	10652211 11714803
SHC1	IL6ST	BioGRID	empirical	9126968
SHC1	ILK	BioGRID	empirical	21900206
SHC1	INPP5D	HPRD, MINT, IntAct, BioGRID	empirical	8643691 8723348 8874179 10704825 12024011 10068665 20697350 10748054 10822173 10194451 10900203
SHC1	INPPL1	HPRD, IntAct, BioGRID	empirical	9660833 19380743 20697350 10194451 11349134
SHC1	INSR	HPRD, MINT, IntAct, MIPS, BioGRID	empirical	9083103 12237775 11075717 10764799 9121430 9446569 10816433 10896916 10921922 9741627 9710204 10482988 8702728 9593725 15629149 9704577 10803466
SHC1	IRS1	HPRD, BioGRID	empirical	7499194
SHC1	ITGB1	MINT	empirical	12606711
SHC1	ITGB2	MINT	empirical	12606711
SHC1	ITGB3	HPRD	empirical	10964917
SHC1	ITGB4	HPRD, BioGRID	empirical	11044453
SHC1	ITGB7	MINT	empirical	12606711
SHC1	JAK2	HPRD, MINT, BioGRID	empirical	7535773 9126968
SHC1	KDR	HPRD, MINT, BioGRID	empirical	10749680 11950700 10319320
SHC1	KRT18	HPRD, IntAct	empirical	12577067
SHC1	LCK	HPRD	empirical	12237775 11075717 10764799 9121430 9446569 10816433 10896916 10921922 9741627 9710204 10482988
SHC1	LCP2	HPRD, MINT	empirical	9716598
SHC1	LRP1	HPRD, BioGRID	empirical	12789267 12069755 11854294
SHC1	LTK	HPRD	empirical	9223670
SHC1	ARNTL	MINT, IntAct	empirical	15102471
SHC1	LYN	HPRD, MINT, BioGRID	empirical	7650013 7516469
SHC1	MET	HPRD, BioGRID	empirical	7731718 9660480
SHC1	MME	HPRD	empirical	9659899
SHC1	MPL	HPRD	empirical	9122198 10224114
SHC1	MST1R	HPRD, BioGRID	empirical	8918464
SHC1	MYO1C	IntAct	empirical	19380743
SHC1	MYO1D	IntAct	empirical	19380743
SHC1	NGFR	HPRD, BioGRID	empirical	7541035
SHC1	NPM1	HPRD, MIPS	empirical	8633037
SHC1	NTRK1	HPRD, BioGRID	empirical	8226808 8155326 7541035 10629055 9856458 8183561 12446789 10092678 10708759 16246731
SHC1	NTRK2	HPRD, BioGRID	empirical	12419535 16034442 10092678
SHC1	NTRK3	HPRD, BioGRID	empirical	7657612 10092678
SHC1	DDR2	HPRD, MINT	empirical	11884411
SHC1	PAK1	HPRD	empirical	15688026
SHC1	PDGFRB	HPRD, BioGRID	empirical	8195171
SHC1	PIK3C2B	BioGRID	empirical	11533253
SHC1	PIK3R1	HPRD, MINT, IntAct, BioGRID	empirical	8662998 8621719 16219545 19380743 7537361
SHC1	PIK3R2	HPRD, IntAct	empirical	8662998 19380743
SHC1	PLCG1	HPRD, BioGRID	empirical	10652211 8155326 8662733
SHC1	PLCG2	HPRD, BioGRID	empirical	10623845 12135708
SHC1	PLSCR1	HPRD, BioGRID	empirical	12009895 12871937
SHC1	DUSP23	BioGRID	empirical	21900206
SHC1	PPP2R5A	HPRD	empirical	11884620
SHC1	OSGEP	BioGRID	empirical	21900206
SHC1	PRKCA	HPRD	empirical	12052829
SHC1	AXL	HPRD	empirical	8610109
SHC1	PRKCD	HPRD, IntAct, BioGRID	empirical	12024011 19380743
SHC1	PAG1	HPRD, BioGRID	empirical	10790433
SHC1	MAPK1	HPRD, BioGRID	empirical	10996427
SHC1	MAPK6	BioGRID	empirical	21900206
SHC1	MAPK8	HPRD	empirical	15688026
SHC1	MAP2K7	Sanger Interaction Map	predicted	15345047
SHC1	PTK2	HPRD, BioGRID	empirical	11980671
SHC1	PTPN2	HPRD	empirical	9488479 15588985
SHC1	PTPN6	HPRD	empirical	8541543
SHC1	PTPN11	HPRD	empirical	10650943
SHC1	PTPN12	HPRD, MINT, IntAct, BioGRID	empirical	7929214 11432829 8626541 12052829 11342545 19380743 20697350
SHC1	RASA1	HPRD	empirical	8155326
SHC1	RET	HPRD, MINT, BioGRID	empirical	8183561 9047384 15677445
SHC1	BCL3	HPRD	empirical	11707390
SHC1	BCR	HPRD	empirical	9209414
SHC1	CEACAM1	HPRD, BioGRID	empirical	11694516
SHC1	SHC1	IntAct	empirical	19380743
SHC1	MRPL44	BioGRID	empirical	21900206
SHC1	SOS1	HPRD, MINT, IntAct	empirical	7520523 8631299 9544989 17673906 19380743
SHC1	SOS2	HPRD, BioGRID	empirical	10675333
SHC1	SP1	HPRD	empirical	7933095
SHC1	SPTA1	IntAct	empirical	19380743
SHC1	SRC	HPRD	empirical	10482988 9710204 9388490 9096689
SHC1	STAT5A	HPRD, BioGRID	empirical	10996427
SHC1	STAT5B	HPRD, BioGRID	empirical	10996427
SHC1	SYK	HPRD	empirical	10482988 9710204 9388490 9096689
SHC1	TEC	HPRD	empirical	11825908
SHC1	TEK	HPRD	empirical	14665640
SHC1	TGFBR1	MINT	empirical	17673906
SHC1	TGFBR2	MINT	empirical	17673906
SHC1	TPR	HPRD	empirical	11896612
SHC1	TUBA4A	IntAct	empirical	20697350
SHC1	UBC	BioGRID	empirical	21264241 21139048 21906983
SHC1	VAV1	HPRD	empirical	15688026
SHC1	ZAP70	HPRD, MINT, BioGRID	empirical	9685404 8761298 7961936 15688026
SHC1	DDR1	HPRD, BioGRID	empirical	10783152 9659899
SHC1	CAD	IntAct	empirical	19380743
SHC1	FAM118B	BioGRID	empirical	21900206
SHC1	LRRK1	IntAct	empirical	20697350
SHC1	SUV39H2	BioGRID	empirical	21900206
SHC1	GEMIN7	BioGRID	empirical	21900206
SHC1	SHCBP1	HPRD, MINT, IntAct, BioGRID	empirical	10086341 15102471
SHC1	CALD1	HPRD, BioGRID	empirical	10559276
SHC1	USP9X	IntAct	empirical	19380743
SHC1	USP9Y	IntAct	empirical	19380743
SHC1	BRSK1	MINT, IntAct	empirical	15102471
SHC1	PPP1R9B	IntAct	empirical	19380743
SHC1	UBASH3B	IntAct	empirical	19380743
SHC1	IKBKAP	IntAct	empirical	19380743
SHC1	PPAP2B	HPRD	empirical	16099422
SHC1	SOCS1	BioGRID	empirical	20622265
SHC1	IRS2	HPRD	empirical	11505033
SHC1	CBL	HPRD, MINT, IntAct, BioGRID	empirical	10570290 8621719 8662998 9234717 15677445 19380743 7657591 9461587
SHC1	CBLB	HPRD, BioGRID	empirical	9614102
SHC1	TAX1BP1	MINT, IntAct	empirical	15102471
SHC1	DOK2	BioGRID	empirical	10822173
SHC1	PSTPIP2	IntAct	empirical	19380743
SHC1	CD3E	HPRD, BioGRID	empirical	11855827
SHC1	CD247	HPRD	empirical	8656061
SHC1	MAPKAPK2	HPRD, BioGRID	empirical	15094067
SHC1	CD22	HPRD, IntAct, BioGRID	empirical	10748054
SHC1	GRAP2	HPRD, BioGRID	empirical	9872323
SHC1	CD81	HPRD	empirical	14676841
SHC1	GAB2	HPRD, MINT, IntAct, BioGRID	empirical	10704825 20697350 12135708 11782427 11287610
SHC1	SEC16A	IntAct	empirical	19380743