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IFIH1

Gene Description:   interferon induced with helicase C domain 1 Synonyms:   MDA5, RGD1560496, IFIH1, 9130009C22Rik, Helicard, MGC90959, MGC133047, Hlcd, MDA-5, Ifih1, IDDM19 Orthologs:   Human IFIH1 (protein-coding), Mouse Ifih1 (protein-coding), Rat Ifih1 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Human-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1 Rat: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
2q24.2	Human	chr2:162960873..163392761	0.43	30	rs1990760

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 2q24.2 Orthologous Region	Rat	chr3:44401046..44815836	0.41	5
Human 2q24.2 Orthologous Region	Mouse	chr2:62285610..62714487	0.43	5

(Human) GRCh37 - chr2:163123589..163175213 (51.62 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr2:62433850..62484312 (50.46 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr3:44547092..44593969 (46.88 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas                 no data no data no data no data no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Interactions Table for IFIH1: The IFIH1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs IFIH1   DAK   Reactome  predicted    IFIH1   DDX60   BioGRID  empirical  21791617

View all

KEGG Network: 3   Influenza A Human - 5164 Mouse - 5164 Rat - 5164 Measles Human - 5162 Mouse - 5162 Rat - 5162 RIG-I-like receptor signaling pathway Human - 4622 Mouse - 4622 Rat - 4622

Biocarta: None available   None available.

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 21   Nucleotide binding GO:0000166 DNA binding GO:0003677 Double-stranded RNA binding GO:0003725 Helicase activity GO:0004386 Protein binding GO:0005515 ATP binding GO:0005524 Intracellular GO:0005622 Nucleus GO:0005634 Cytoplasm GO:0005737 Cytosol GO:0005829 Zinc ion binding GO:0008270 Detection of virus GO:0009597 Hydrolase activity, acting on acid anhydrides GO:0016817 Negative regulation of type I interferon production GO:0032480 Positive regulation of interferon-alpha production GO:0032727 Positive regulation of interferon-beta production GO:0032728 Regulation of apoptosis GO:0042981 Ribonucleoprotein binding GO:0043021 Interspecies interaction between organisms GO:0044419 Innate immune response GO:0045087 Metal ion binding GO:0046872

	KEGG Network: 3 Influenza A Human - 5164 Mouse - 5164 Rat - 5164 Measles Human - 5162 Mouse - 5162 Rat - 5162 RIG-I-like receptor signaling pathway Human - 4622 Mouse - 4622 Rat - 4622
	Biocarta: None available
	Reactome: None available
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 21 Nucleotide binding GO:0000166 DNA binding GO:0003677 Double-stranded RNA binding GO:0003725 Helicase activity GO:0004386 Protein binding GO:0005515 ATP binding GO:0005524 Intracellular GO:0005622 Nucleus GO:0005634 Cytoplasm GO:0005737 Cytosol GO:0005829 Zinc ion binding GO:0008270 Detection of virus GO:0009597 Hydrolase activity, acting on acid anhydrides GO:0016817 Negative regulation of type I interferon production GO:0032480 Positive regulation of interferon-alpha production GO:0032727 Positive regulation of interferon-beta production GO:0032728 Regulation of apoptosis GO:0042981 Ribonucleoprotein binding GO:0043021 Interspecies interaction between organisms GO:0044419 Innate immune response GO:0045087 Metal ion binding GO:0046872

Type 1 Diabetes Publications: 29

• RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice.
  McCartney SA, Vermi W, Lonardi S, Rossini C, Otero K, Calderon B, Gilfillan S, Diamond MS, Unanue ER, Colonna M
  J Clin Invest. 2011
  PubMed ID: 21403398
   
  
• RIG-I- and MDA5-Initiated Innate Immunity Linked With Adaptive Immunity Accelerates {beta}-Cell Death in Fulminant Type 1 Diabetes.
  Aida K, Nishida Y, Tanaka S, Maruyama T, Shimada A, Awata T, Suzuki M, Shimura H, Takizawa S, Ichijo M, Akiyama D, Furuya F, Kawaguchi A, Kaneshige M, Itakura J, Fujii H, Endo T, Kobayashi T
  Diabetes. 2011
  PubMed ID: 21289206
   
  
• An interferon-induced helicase (IFIH1) gene polymorphism associates with different rates of progression from autoimmunity to type 1 diabetes.
  Winkler C, Lauber C, Adler K, Grallert H, Illig T, Ziegler AG, Bonifacio E
  Diabetes. 2011
  PubMed ID: 21270278
   
  
• Loss-of-function mutations E6 27X and I923V of IFIH1 are associated with lower poly(I:C)-induced interferon-β production in peripheral blood mononuclear cells of type 1 diabetes patients.
  Chistiakov DA, Voronova NV, Savost'Anov KV, Turakulov RI
  Hum Immunol. 2010
  PubMed ID: 20736039
   
  
• Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
  Ferreira RC, Pan-Hammarström Q, Graham RR, Gateva V, Fontán G, Lee AT, Ortmann W, Urcelay E, Fernández-Arquero M, Núñez C, Jorgensen G, Ludviksson BR, Koskinen S, Haimila K, Clark HF, Klareskog L, Gregersen PK, Behrens TW, Hammarström L
  Nat Genet. 2010
  PubMed ID: 20694011
   
  
• Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.
  Hinks A, Martin P, Flynn E, Eyre S, Packham J, Barton A, Childhood Arthritis Prospective Study (CAPS), UKRAG Consortium, BSPAR study group, Worthington J, Thomson W
  Ann Rheum Dis. 2010
  PubMed ID: 20647273
   
  
• Population genetics of IFIH1: ancient population structure, local selection and implications for susceptibility to type 1 diabetes.
  Fumagalli M, Cagliani R, Riva S, Pozzoli U, Biasin M, Piacentini L, Comi GP, Bresolin N, Clerici M, Sironi M
  Mol Biol Evol. 2010
  PubMed ID: 20538742
   
  
• No evidence of association of the rare nsSNP rs35667974 in IFIH1 with multiple sclerosis.
  Bergamaschi L, Ban M, Leone MA, Sawcer SJ, D'Alfonso S
  J Neuroimmunol. 2010
  PubMed ID: 20116863
   
  
• Reduced expression of IFIH1 is protective for type 1 diabetes.
  Downes K, Pekalski M, Angus KL, Hardy M, Nutland S, Smyth DJ, Walker NM, Wallace C, Todd JA
  PLoS One. 2010
  PubMed ID: 20844740
   
  
• Study of transcriptional effects in Cis at the IFIH1 locus.
  Zouk H, Marchand L, Polychronakos C
  PLoS One. 2010
  PubMed ID: 20644636
   
  
• Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.
  Pierce BL, Ahsan H
  Hum Hered. 2010
  PubMed ID: 20203524
   
  
• Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects.
  Klinker MW, Schiller JJ, Magnuson VL, Wang T, Basken J, Veth K, Pearce KI, Kinnunen L, Harjutsalo V, Wang X, Tuomilehto J, Sarti C, Ghosh S
  Immunogenetics. 2009
  PubMed ID: 20033399
   
  
• The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations.
  Jermendy A, Szatmári I, Laine AP, Lukács K, Horváth KH, Körner A, Madácsy L, Veijola R, Simell O, Knip M, Ilonen J, Hermann R, The Finnish Paediatric Diabetes Registry, The HUNT1DGENES Programme
  Diabetologia. 2009
  PubMed ID: 19841890
   
  
• MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic {beta}-cell responses to the viral by-product double stranded RNA.
  Colli ML, Moore F, Gurzov EN, Ortis F, Eizirik DL
  Hum Mol Genet. 2009
  PubMed ID: 19825843
   
  
• Coexpression network based on natural variation in human gene expression reveals gene interactions and functions.
  Nayak RR, Kearns M, Spielman RS, Cheung VG
  Genome Res. 2009
  PubMed ID: 19797678
   
  
• IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype - phenotype correlation in the Belgian population.
  Aminkeng F, Van Autreve JE, Weets I, Quartier E, Van Schravendijk C, Gorus FK, Van der Auwera BJ, Belgian Diabetes Registry
  Hum Immunol. 2009
  PubMed ID: 19539001
   
  
• Identification of loss of function mutations in human genes encoding RIG-I and MDA5: implications for resistance to type I diabetes.
  Shigemoto T, Kageyama M, Hirai R, Zheng J, Yoneyama M, Fujita T
  J Biol Chem. 2009
  PubMed ID: 19324880
   
  
• Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
  Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS, The Type 1 Diabetes Genetics Consortium
  Nat Genet. 2009
  PubMed ID: 19430480
   
  
• Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes.
  Nejentsev S, Walker N, Riches D, Egholm M, Todd JA
  Science. 2009
  PubMed ID: 19264985
   
  
• The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease.
  Penna-Martinez M, Ramos-Lopez E, Robbers I, Kahles H, Hahner S, Willenberg H, Reisch N, Seidl C, Segni M, Badenhoop K
  BMC Med Genet. 2009
  PubMed ID: 19961590
   
  
• Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis.
  Carr EJ, Niederer HA, Williams J, Harper L, Watts RA, Lyons PA, Smith KG
  BMC Med Genet. 2009
  PubMed ID: 19951419
   
  
• Shared and distinct genetic variants in type 1 diabetes and celiac disease.
  Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA, Todd JA
  N Engl J Med. 2008
  PubMed ID: 19073967
   
  
• The IFIH1 Polymorphisms Are Significantly Associated with Type 1 Diabetes and IFIH1 Gene Expression in Peripheral Blood Mononuclear Cells.
  Liu S, Wang H, Jin Y, Podolsky R, Linga Reddy MV, Pedersen J, Bode B, Reed J, Steed D, Anderson S, Yang P, Muir A, Steed L, Hopkins D, Huang Y, Purohit S, Wang CY, Steck AK, Montemari A, Eisenbarth G, Rewers M, She JX
  Hum Mol Genet. 2008
  PubMed ID: 18927125
   
  
• The association between the IFIH1 locus and type 1 diabetes.
  Qu HQ, Marchand L, Grabs R, Polychronakos C
  Diabetologia. 2008
  PubMed ID: 18071670
   
  
• IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk.
  Martínez A, Santiago JL, Cénit MC, de Las Heras V, de la Calle H, Fernández-Arquero M, Arroyo R, de la Concha EG, Urcelay E
  Eur J Hum Genet. 2008
  PubMed ID: 18285833
   
  
• Interferons induce an antiviral state in human pancreatic islet cells.
  Hultcrantz M, Hühn MH, Wolf M, Olsson A, Jacobson S, Williams BR, Korsgren O, Flodström-Tullberg M
  Virology. 2007
  PubMed ID: 17559902
   
  
• Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility.
  Sutherland A, Davies J, Owen CJ, Vaikkakara S, Walker C, Cheetham TD, James RA, Perros P, Donaldson PT, Cordell HJ, Quinton R, Pearce SH
  J Clin Endocrinol Metab. 2007
  PubMed ID: 17535987
   
  
• The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis.
  Marinou I, Montgomery DS, Dickson MC, Binks MH, Moore DJ, Bax DE, Wilson AG
  Arthritis Res Ther. 2007
  PubMed ID: 17442111
   
  
• A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.
  Smyth DJ, Cooper JD, Bailey R, Field S, Burren O, Smink LJ, Guja C, Ionescu-Tirgoviste C, Widmer B, Dunger DB, Savage DA, Walker NM, Clayton DG, Todd JA
  Nat Genet. 2006
  PubMed ID: 16699517
   
  

Publications: 106

• Enhanced skin expression of melanoma differentiation-associated gene 5 (MDA5) in dermatomyositis and related autoimmune diseases.
  Zahn S, Barchet W, Rehkämper C, Hornung T, Bieber T, Tüting T, Wenzel J
  J Am Acad Dermatol. 2011
  PubMed ID: 21496705
   
  
• Nucleotide-binding and oligomerization domain-like receptors and retinoic acid inducible gene-like receptors in human tonsillar T lymphocytes.
  Petterson T, Månsson A, Riesbeck K, Cardell LO
  Immunology. 2011
  PubMed ID: 21342182
   
  
• Serum ferritin correlates with activity of anti-MDA5 antibody-associated acute interstitial lung disease as a complication of dermatomyositis.
  Gono T, Kawaguchi Y, Ozeki E, Ota Y, Satoh T, Kuwana M, Hara M, Yamanaka H
  Mod Rheumatol. 2011
  PubMed ID: 21052763
   
  
• TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection.
  Jelinek I, Leonard JN, Price GE, Brown KN, Meyer-Manlapat A, Goldsmith PK, Wang Y, Venzon D, Epstein SL, Segal DM
  J Immunol. 2011
  PubMed ID: 21242525
   
  
• Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.
  Züst R, Cervantes-Barragan L, Habjan M, Maier R, Neuman BW, Ziebuhr J, Szretter KJ, Baker SC, Barchet W, Diamond MS, Siddell SG, Ludewig B, Thiel V
  Nat Immunol. 2011
  PubMed ID: 21217758
   
  
• RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium.
  Broquet AH, Hirata Y, McAllister CS, Kagnoff MF
  J Immunol. 2011
  PubMed ID: 21187438
   
  
• The C proteins of human parainfluenza virus type 1 limit double-stranded RNA accumulation that would otherwise trigger activation of MDA5 and protein kinase R.
  Boonyaratanakornkit J, Bartlett E, Schomacker H, Surman S, Akira S, Bae YS, Collins P, Murphy B, Schmidt A
  J Virol. 2011
  PubMed ID: 21123378
   
  
• Initial characterization of the human central proteome.
  Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
  BMC Syst Biol. 2011
  PubMed ID: 21269460
   
  
• RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection.
  Nasirudeen AM, Wong HH, Thien P, Xu S, Lam KP, Liu DX
  PLoS Negl Trop Dis. 2011
  PubMed ID: 21245912
   
  
• Human rhinovirus recognition in non-immune cells is mediated by Toll-like receptors and MDA-5, which trigger a synergetic pro-inflammatory immune response.
  Triantafilou K, Vakakis E, Richer EA, Evans GL, Villiers JP, Triantafilou M
  Virulence. 2011
  PubMed ID: 21224721
   
  
• MDA5 is SUMOylated by PIAS2β in the upregulation of type I interferon signaling.
  Fu J, Xiong Y, Xu Y, Cheng G, Tang H
  Mol Immunol. 2011
  PubMed ID: 21156324
   
  
• Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-β-inducing potential.
  Takaki H, Watanabe Y, Shingai M, Oshiumi H, Matsumoto M, Seya T
  Mol Immunol. 2011
  PubMed ID: 21071089
   
  
• Carriers of rare missense variants in IFIH1 are protected from psoriasis.
  Li Y, Liao W, Cargill M, Chang M, Matsunami N, Feng BJ, Poon A, Callis-Duffin KP, Catanese JJ, Bowcock AM, Leppert MF, Kwok PY, Krueger GG, Begovich AB
  J Invest Dermatol. 2010
  PubMed ID: 20668468
   
  
• Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease.
  Gibbert K, Dietze KK, Zelinskyy G, Lang KS, Barchet W, Kirschning CJ, Dittmer U
  J Immunol. 2010
  PubMed ID: 20943997
   
  
• A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
  Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2, Strange A, Capon F, Spencer CC, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, Bergboer JG, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Cork MJ, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, Estivill X, Fitzgerald O, Freeman C, Giardina E, Gray E, Hofer A, Hüffmeier U, Hunt SE, Irvine AD, Jankowski J, Kirby B, Langford C, Lascorz J, Leman J, Leslie S, Mallbris L, Markus HS, Mathew CG, McLean WH, McManus R, Mössner R, Moutsianas L, Naluai AT, Nestle FO, Novelli G, Onoufriadis A, Palmer CN, Perricone C, Pirinen M, Plomin R, Potter SC, Pujol RM, Rautanen A, Riveira-Munoz E, Ryan AW, Salmhofer W, Samuelsson L, Sawcer SJ, Schalkwijk J, Smith CH, Ståhle M, Su Z, Tazi-Ahnini R, Traupe H, Viswanathan AC, Warren RB, Weger W, Wolk K, Wood N, Worthington J, Young HS, Zeeuwen PL, Hayday A, Burden AD, Griffiths CE, Kere J, Reis A, McVean G, Evans DM, Brown MA, Barker JN, Peltonen L, Donnelly P, Trembath RC
  Nat Genet. 2010
  PubMed ID: 20953190
   
  
• Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways.
  Melchjorsen J, Rintahaka J, Søby S, Horan KA, Poltajainen A, Østergaard L, Paludan SR, Matikainen S
  J Virol. 2010
  PubMed ID: 20739519
   
  
• Dissociation of paramyxovirus interferon evasion activities: universal and virus-specific requirements for conserved V protein amino acids in MDA5 interference.
  Ramachandran A, Horvath CM
  J Virol. 2010
  PubMed ID: 20719949
   
  
• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
  Diabetes Care. 2010
  PubMed ID: 20628086
   
  
• Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients.
  Enevold C, Oturai AB, Sørensen PS, Ryder LP, Koch-Henriksen N, Bendtzen K
  Mult Scler. 2010
  PubMed ID: 20595247
   
  
• Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response.
  Swanson CL, Wilson TJ, Strauch P, Colonna M, Pelanda R, Torres RM
  J Exp Med. 2010
  PubMed ID: 20566717
   
  
• Murine coronavirus induces type I interferon in oligodendrocytes through recognition by RIG-I and MDA5.
  Li J, Liu Y, Zhang X
  J Virol. 2010
  PubMed ID: 20427526
   
  
• Melanoma differentiation-associated protein-5 (MDA-5) limits early viral replication but is not essential for the induction of type 1 interferons after Coxsackievirus infection.
  Hühn MH, McCartney SA, Lind K, Svedin E, Colonna M, Flodström-Tullberg M
  Virology. 2010
  PubMed ID: 20206372
   
  
• Viral apoptosis is induced by IRF-3-mediated activation of Bax.
  Chattopadhyay S, Marques JT, Yamashita M, Peters KL, Smith K, Desai A, Williams BR, Sen GC
  EMBO J. 2010
  PubMed ID: 20360684
   
  
• Interferon-induced helicase (IFIH1) polymorphism with systemic lupus erythematosus and dermatomyositis/polymyositis.
  Gono T, Kawaguchi Y, Sugiura T, Furuya T, Kawamoto M, Hanaoka M, Yamanaka H
  Mod Rheumatol. 2010
  PubMed ID: 20467774
   
  
• NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.
  Cui J, Zhu L, Xia X, Wang HY, Legras X, Hong J, Ji J, Shen P, Zheng S, Chen ZJ, Wang RF
  Cell. 2010
  PubMed ID: 20434986
   
  
• Cutting edge: polyinosinic:polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells.
  Wang Y, Cella M, Gilfillan S, Colonna M
  J Immunol. 2010
  PubMed ID: 20164430
   
  
• An accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses.
  DeWitte-Orr SJ, Collins SE, Bauer CM, Bowdish DM, Mossman KL
  PLoS Pathog. 2010
  PubMed ID: 20360967
   
  
• The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody.
  Nakashima R, Imura Y, Kobayashi S, Yukawa N, Yoshifuji H, Nojima T, Kawabata D, Ohmura K, Usui T, Fujii T, Okawa K, Mimori T
  Rheumatology (Oxford). 2010
  PubMed ID: 20015976
   
  
• Type I IFN controls chikungunya virus via its action on nonhematopoietic cells.
  Schilte C, Couderc T, Chretien F, Sourisseau M, Gangneux N, Guivel-Benhassine F, Kraxner A, Tschopp J, Higgs S, Michault A, Arenzana-Seisdedos F, Colonna M, Peduto L, Schwartz O, Lecuit M, Albert ML
  J Exp Med. 2010
  PubMed ID: 20123960
   
  
• LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.
  Satoh T, Kato H, Kumagai Y, Yoneyama M, Sato S, Matsushita K, Tsujimura T, Fujita T, Akira S, Takeuchi O
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20080593
   
  
• Immunostimulatory RNA blocks suppression by regulatory T cells.
  Anz D, Koelzer VH, Moder S, Thaler R, Schwerd T, Lahl K, Sparwasser T, Besch R, Poeck H, Hornung V, Hartmann G, Rothenfusser S, Bourquin C, Endres S
  J Immunol. 2010
  PubMed ID: 19966212
   
  
• Rabies virus infection induces type I interferon production in an IPS-1 dependent manner while dendritic cell activation relies on IFNAR signaling.
  Faul EJ, Wanjalla CN, Suthar MS, Gale M, Wirblich C, Schnell MJ
  PLoS Pathog. 2010
  PubMed ID: 20661430
   
  
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