Home BCR
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(Human) GRCh37 - chr22:23521891..23660224 (138.33 kb) View in Genome Browser
(Mouse) NCBIM37 - chr10:74523641..74647668 (1243 kb) View in Genome Browser
(Rat) RGSC3.4 - chr20:13972773..14097816 (1254 kb) View in Genome Browser
HaemAtlas Expression Table for BCR:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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Expression Legend
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for BCR:The BCR interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| BCR | STUB1 | BioGRID | empirical | 20675402 |
| BCR | GIPC1 | MINT | empirical | 15494376 |
| BCR | CFTR | MINT, IntAct | empirical | 15494376 17110338 |
| BCR | YWHAQ | HPRD | empirical | 16045749 |
| BCR | MAP4K5 | HPRD | empirical | 9949177 |
| BCR | CLTC | MINT | empirical | 15494376 |
| BCR | COPB1 | MINT | empirical | 15494376 |
| BCR | CRK | HPRD, IntAct | empirical | 8978305 20697350 |
| BCR | CRKL | HPRD, BioGRID | empirical | 8978305 9747873 10194128 15143164 |
| BCR | GRASP | MINT | empirical | 12586822 |
| BCR | DLG1 | HPRD | empirical | 16825666 |
| BCR | DOK1 | IntAct | empirical | 20697350 |
| BCR | ERCC3 | HPRD, BioGRID | empirical | 9874796 17643375 |
| BCR | FES | HPRD, BioGRID | empirical | 7529874 8955135 10706130 |
| BCR | ABL1 | HPRD, BioGRID | empirical | 11780146 12543778 1712671 8112292 |
| BCR | ABL2 | HPRD | empirical | 1383690 |
| BCR | SFN | HPRD | empirical | 16045749 |
| BCR | GRB2 | HPRD, MINT, IntAct, BioGRID | empirical | 8112292 9178913 9826659 20697350 21706016 10887132 9747873 15143164 7529874 |
| BCR | GRB10 | HPRD, BioGRID | empirical | 9747873 |
| BCR | HCK | HPRD, BioGRID | empirical | 9178913 12522270 8955135 9407116 12592324 10849448 |
| BCR | HOXA9 | BioGRID | empirical | 12393433 |
| BCR | HSPA8 | BioGRID | empirical | 20675402 |
| BCR | HSP90AA1 | BioGRID | empirical | 21248063 20675402 |
| BCR | IL3 | BioGRID | empirical | 9209414 |
| BCR | INPP5D | BioGRID | empirical | 20304029 |
| BCR | IRS1 | HPRD | empirical | 12560071 |
| BCR | JAK2 | HPRD | empirical | 12370803 12023981 |
| BCR | KIT | BioGRID | empirical | 8757502 |
| BCR | RHOA | BioGRID | empirical | 9535855 |
| BCR | MLLT4 | MINT, BioGRID | empirical | 17491594 12808105 |
| BCR | MYC | IntAct, BioGRID | empirical | 17314511 |
| BCR | ATP2B1 | MINT | empirical | 15494376 |
| BCR | VPS28 | BioGRID | empirical | 16778200 |
| BCR | PDZK1 | MINT | empirical | 15494376 |
| BCR | PIK3CG | BioGRID | empirical | 9747873 8641358 7606002 |
| BCR | PIK3R1 | MINT | empirical | 16219545 |
| BCR | PLCG1 | HPRD | empirical | 1383690 |
| BCR | WDR48 | IntAct, BioGRID | empirical | 19615732 |
| BCR | PTPN1 | HPRD, MINT | empirical | 9566916 |
| BCR | PTPN6 | HPRD, BioGRID | empirical | 9211920 9788431 |
| BCR | PTPN11 | HPRD | empirical | 12115002 |
| BCR | PXN | BioGRID | empirical | 8641358 7534286 |
| BCR | RAC1 | BioGRID | empirical | 9535855 |
| BCR | RASA1 | HPRD | empirical | 1383690 |
| BCR | RB1 | BioGRID | empirical | 9071815 |
| BCR | RGS12 | MINT | empirical | 15494376 |
| BCR | BCR | HPRD | empirical | 11780146 |
| BCR | BLK | HPRD | empirical | 8756631 |
| BCR | SHC1 | HPRD | empirical | 9209414 |
| BCR | BMPR1B | BioGRID | empirical | 15761153 |
| BCR | SRC | HPRD | empirical | 1383690 |
| BCR | HNF1A | HPRD | empirical | 16442529 |
| BCR | TCF7 | MINT | empirical | 16442529 |
| BCR | TLN1 | BioGRID | empirical | 8641358 |
| BCR | TP53 | HPRD, MINT, IntAct, BioGRID | empirical | 16169070 |
| BCR | TSG101 | BioGRID | empirical | 16778200 |
| BCR | UBC | BioGRID | empirical | 20675402 21139048 21906983 |
| BCR | VAV1 | HPRD | empirical | 11790798 |
| BCR | YWHAB | HPRD | empirical | 16045749 |
| BCR | YWHAE | HPRD | empirical | 16045749 |
| BCR | YWHAG | HPRD | empirical | 16045749 |
| BCR | YWHAH | HPRD | empirical | 16045749 |
| BCR | YWHAZ | HPRD | empirical | 7939633 16045749 |
| BCR | LRRK1 | IntAct | empirical | 20697350 |
| BCR | IGSF21 | HPRD, MINT, IntAct, BioGRID | empirical | 16169070 |
| BCR | CBL | BioGRID | empirical | 8641358 20675402 |
| BCR | DOK2 | IntAct | empirical | 20697350 |
| BCR | UNC119 | HPRD, MINT, IntAct, BioGRID | empirical | 16169070 |
| BCR | TJP2 | MINT | empirical | 15494376 |
| BCR | APBA3 | HPRD, MINT | empirical | 15494376 |
| BCR | GAB2 | BioGRID | empirical | 15143164 |
| BCR | CDC42 | BioGRID | empirical | 9535855 |
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Type 1 Diabetes Publications: 1
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A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDNA clones.
Takeda J, Yano H, Eng S, Zeng Y, Bell GI
Hum Mol Genet. 1993
PubMed ID: 7506601
Publications: 360
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FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling.
Sohn HW, Krueger PD, Davis RS, Pierce SK
Blood. 2011
PubMed ID: 21908428
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Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemia.
Cazzaniga G, van Delft FW, Lo Nigro L, Ford AM, Score J, Iacobucci I, Mirabile E, Taj M, Colman SM, Biondi A, Greaves M
Blood. 2011
PubMed ID: 21960589
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NF-κB suppresses ROS levels in BCR-ABL(+) cells to prevent activation of JNK and cell death.
Stein SJ, Baldwin AS
Oncogene. 2011
PubMed ID: 21625221
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CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis.
Zhuang C, Tang H, Dissanaike S, Cobos E, Tao Y, Dai Z
J Biol Chem. 2011
PubMed ID: 21900237
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Bcr-Abl oncogene stimulates Jab1 expression via cooperative interaction of β-catenin and STAT1 in chronic myeloid leukemia cells.
Yang KT, Wang MC, Chen JY, Hsu MC, Hung WC
J Cell Physiol. 2011
PubMed ID: 21935931
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BCR-ABL transcript dynamics support the hypothesis that leukemic stem cells are reduced during imatinib treatment.
Stein AM, Bottino D, Modur V, Branford S, Kaeda J, Goldman JM, Hughes TP, Radich JP, Hochhaus A
Clin Cancer Res. 2011
PubMed ID: 21903771
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Low-level Bcr-Abl mutations are very rare in chronic myeloid leukemia patients who are in major molecular response on first-line nilotinib.
Soverini S, Gnani A, De Benedittis C, Castagnetti F, Gugliotta G, Iacobucci I, Palandri F, Rosti G, Testoni N, Luatti S, Marzocchi G, Baccarani M, Martinelli G
Leuk Res. 2011
PubMed ID: 21762985
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Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis.
Grebien F, Hantschel O, Wojcik J, Kaupe I, Kovacic B, Wyrzucki AM, Gish GD, Cerny-Reiterer S, Koide A, Beug H, Pawson T, Valent P, Koide S, Superti-Furga G
Cell. 2011
PubMed ID: 22000011
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Agammaglobulinemia associated with BCR⁻ B cells and enhanced expression of CD19.
Dobbs AK, Bosompem A, Coustan-Smith E, Tyerman G, Saulsbury FT, Conley ME
Blood. 2011
PubMed ID: 21693761
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In vivo imaging of Bcr-Abl overexpressing tumors with a radiolabeled imatinib analog as an imaging surrogate for imatinib.
Glekas AP, Pillarsetty NK, Punzalan B, Khan N, Smith-Jones P, Larson SM
J Nucl Med. 2011
PubMed ID: 21764785
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F317L BCR-ABL1 kinase domain mutation associated with a sustained major molecular response in a CML patient on dasatinib.
Oyekunle AA, Castagnetti F, Gugliotta G, Soverini S, Baccarani M, Rosti G
Leuk Res. 2011
PubMed ID: 21489624
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A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
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Purification of TAT-CC-HA protein under native condition, and its transduction analysis and biological effects on BCR-ABL positive cells.
Huang Z, Ji M, Peng Z, Huang S, Xiao Q, Li C, Zeng J, Gao M, Feng W
Biomed Pharmacother. 2011
PubMed ID: 21641753
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Does pretreatment fluorescence in situ hybridization for BCR-ABL predict imatinib-associated hematologic toxicity in chronic myeloid leukemia?
Lima LM, Sampat K, Assouline S, Saxe D, Nault S, Tighiouart M, McLemore M, Arellano M, Winton E, Bernal-Mizrachi L, Cortes J, Khoury HJ
Leuk Lymphoma. 2011
PubMed ID: 21504383
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Three novel alternative splicing mutations in BCR-ABL1 detected in CML patients with resistance to kinase inhibitors.
Ma W, Giles F, Zhang X, Wang X, Zhang Z, Lee TS, Yeh CH, Albitar M
Int J Lab Hematol. 2011
PubMed ID: 21266020
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BCR-ABL1 mutations in patients with imatinib-resistant Philadelphia chromosome-positive leukemia by use of the PCR-Invader assay.
Ono T, Miyawaki S, Kimura F, Kanamori H, Ohtake S, Kitamura K, Fujita H, Sugiura I, Usuki K, Emi N, Tamaki S, Aoyama Y, Kaya H, Naoe T, Tadokoro K, Yamaguchi T, Ohno R, Ohnishi K, Japan Adult Leukemia Study Group
Leuk Res. 2011
PubMed ID: 21239056
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Targeting ovarian tumor cell adhesion mediated by tissue transglutaminase.
Khanna M, Chelladurai B, Gavini A, Li L, Shao M, Courtney D, Turchi JJ, Matei D, Meroueh S
Mol Cancer Ther. 2011
PubMed ID: 21330459
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Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia.
Boulos N, Mulder HL, Calabrese CR, Morrison JB, Rehg JE, Relling MV, Sherr CJ, Williams RT
Blood. 2011
PubMed ID: 21263154
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Results of allogeneic hematopoietic stem cell transplantation for chronic myelogenous leukemia patients who failed tyrosine kinase inhibitors after developing BCR-ABL1 kinase domain mutations.
Jabbour E, Cortes J, Santos FP, Jones D, O'Brien S, Rondon G, Popat U, Giralt S, Kebriaei P, Jones RB, Kantarjian H, Champlin R, de Lima M
Blood. 2011
PubMed ID: 21156844
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Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.
Sun H, Kapuria V, Peterson LF, Fang D, Bornmann WG, Bartholomeusz G, Talpaz M, Donato NJ
Blood. 2011
PubMed ID: 21248063
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Janus kinase 2 regulates Bcr-Abl signaling in chronic myeloid leukemia.
Samanta A, Perazzona B, Chakraborty S, Sun X, Modi H, Bhatia R, Priebe W, Arlinghaus R
Leukemia. 2011
PubMed ID: 21183952
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Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells.
Chen JY, Wang MC, Hung WC
J Cell Physiol. 2011
PubMed ID: 20717963
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Use of direct sequencing for detection of mutations in the BCR-ABL kinase domain in Slovak patients with chronic myeloid leukemia.
Strhakova L, Bujalkova MG, Hojsikova I, Lukackova R, Behulova R, Mistrik M, Repiska V
Neoplasma. 2011
PubMed ID: 21895409
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Frequency of BCR-ABL fusion transcripts in Serbian patients with chronic myeloid leukemia.
Todoric-Zivanovic B, Strnad M, Stamatovic D, Tukic L, Krtolica K, Tatomirovic Z, Djordjevic V, Bogdanovic A, Jankovic G, Magic Z
J BUON. 2011
PubMed ID: 21674858
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Bcr is a substrate for Transglutaminase 2 cross-linking activity.
Yi SJ, Groffen J, Heisterkamp N
BMC Biochem. 2011
PubMed ID: 21310073
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Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.
Titz B, Low T, Komisopoulou E, Chen SS, Rubbi L, Graeber TG
Oncogene. 2010
PubMed ID: 20697350
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Bag1 directly routes immature BCR-ABL for proteasomal degradation.
Tsukahara F, Maru Y
Blood. 2010
PubMed ID: 20675402
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Exon 7 deletion in the bcr-abl gene is frequent in chronic myeloid leukemia patients and is not correlated with resistance against imatinib.
Gaillard JB, Arnould C, Bravo S, Donadio D, Exbrayat C, Jourdan E, Reboul D, Chiesa J, Lavabre-Bertrand T
Mol Cancer Ther. 2010
PubMed ID: 21045136
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Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.
Oh D, Han S, Seo J, Lee JR, Choi J, Groffen J, Kim K, Cho YS, Choi HS, Shin H, Woo J, Won H, Park SK, Kim SY, Jo J, Whitcomb DJ, Cho K, Kim H, Bae YC, Heisterkamp N, Choi SY, Kim E
J Neurosci. 2010
PubMed ID: 20962234
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Analysis of BCR-ABL1 tyrosine kinase domain mutational spectra in primitive chronic myeloid leukemia cells suggests a unique mutator phenotype.
Grant H, Jiang X, Stebbing J, Foroni L, Craddock C, Griffiths M, Clark RE, O'Brien S, Khorashad JS, Gerrard G, Wang L, Irving JA, Wang M, Karran L, Dyer MJ, Forrest D, Page K, Eaves CJ, Woolfson A
Leukemia. 2010
PubMed ID: 20739956
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Associations between imatinib resistance conferring mutations and Philadelphia positive clonal cytogenetic evolution in CML.
Schnittger S, Bacher U, Dicker F, Kern W, Alpermann T, Haferlach T, Haferlach C
Genes Chromosomes Cancer. 2010
PubMed ID: 20607847
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The MAPK/ERK and PI3K pathways additively coordinate the transcription of recombination-activating genes in B lineage cells.
Novak R, Jacob E, Haimovich J, Avni O, Melamed D
J Immunol. 2010
PubMed ID: 20709952
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A unique BCR-ABL1 transcript with the insertion of intronic sequence from BCR and ABL1 genes in a patient with Philadelphia-positive chronic myeloid leukemia: a case study.
Sadia H, Siddiqui RT, Nasim A
Cancer Genet Cytogenet. 2010
PubMed ID: 20633771
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BCR and BCR-ABL regulation during myeloid differentiation in healthy donors and in chronic phase/blast crisis CML patients.
Marega M, Piazza RG, Pirola A, Redaelli S, Mogavero A, Iacobucci I, Meneghetti I, Parma M, Pogliani EM, Gambacorti-Passerini C
Leukemia. 2010
PubMed ID: 20520635
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Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner.
Pene-Dumitrescu T, Smithgall TE
J Biol Chem. 2010
PubMed ID: 20452982
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Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
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Genome-wide examination of genetic variants associated with response to platinum-based chemotherapy in patients with small-cell lung cancer.
Wu C, Xu B, Yuan P, Ott J, Guan Y, Liu Y, Liu Z, Shen Y, Yu D, Lin D
Pharmacogenet Genomics. 2010
PubMed ID: 20463552
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Expression of oncogenic kinase Bcr-Abl impairs mitotic checkpoint and promotes aberrant divisions and resistance to microtubule-targeting agents.
Wolanin K, Magalska A, Kusio-Kobialka M, Podszywalow-Bartnicka P, Vejda S, McKenna SL, Mosieniak G, Sikora E, Piwocka K
Mol Cancer Ther. 2010
PubMed ID: 20442314
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Tyrosine phosphorylation of SHIP promotes its proteasomal degradation.
Ruschmann J, Ho V, Antignano F, Kuroda E, Lam V, Ibaraki M, Snyder K, Kim C, Flavell RA, Kawakami T, Sly L, Turhan AG, Krystal G
Exp Hematol. 2010
PubMed ID: 20304029
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Co-expression of HoxA9 and bcr-abl genes in chronic myeloid leukemia.
Tedeschi FA, Cardozo MA, Valentini R, Zalazar FE
Leuk Lymphoma. 2010
PubMed ID: 20141430
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A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice.
Endoh-Yamagami S, Karkar KM, May SR, Cobos I, Thwin MT, Long JE, Ashique AM, Zarbalis K, Rubenstein JL, Peterson AS
Dev Biol. 2010
PubMed ID: 20096683
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Impact of additional chromosomal aberrations and BCR-ABL kinase domain mutations on the response to nilotinib in Philadelphia chromosome-positive chronic myeloid leukemia.
Kim TD, Türkmen S, Schwarz M, Koca G, Nogai H, Bommer C, Dörken B, Daniel P, le Coutre P
Haematologica. 2010
PubMed ID: 20015884
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Poor replication of candidate genes for major depressive disorder using genome-wide association data.
Bosker FJ, Hartman CA, Nolte IM, Prins BP, Terpstra P, Posthuma D, van Veen T, Willemsen G, Derijk RH, de Geus EJ, Hoogendijk WJ, Sullivan PF, Penninx BW, Boomsma DI, Snieder H, Nolen WA
Mol Psychiatry. 2010
PubMed ID: 20351714
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Small interfering RNA against BCR-ABL transcripts sensitize mutated T315I cells to nilotinib.
Koldehoff M, Kordelas L, Beelen DW, Elmaagacli AH
Haematologica. 2010
PubMed ID: 20207846
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Reduction of Raf kinase inhibitor protein expression by Bcr-Abl contributes to chronic myelogenous leukemia proliferation.
Takemura T, Nakamura S, Yokota D, Hirano I, Ono T, Shigeno K, Fujisawa S, Ohnishi K
J Biol Chem. 2010
PubMed ID: 20028985
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BCR-ABL gene expression is required for its mutations in a novel KCL-22 cell culture model for acquired resistance of chronic myelogenous leukemia.
Yuan H, Wang Z, Gao C, Chen W, Huang Q, Yee JK, Bhatia R, Chen W
J Biol Chem. 2010
PubMed ID: 20007699
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Kinase domain mutations of BCR-ABL identified at diagnosis before imatinib-based therapy are associated with progression in patients with high Sokal risk chronic phase chronic myeloid leukemia.
Carella AM, Garuti A, Cirmena G, Catania G, Rocco I, Palermo C, Pica G, Pierri I, Miglino M, Ballestrero A, Gobbi M, Patrone F
Leuk Lymphoma. 2010
PubMed ID: 20038234
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Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells.
Valeri A, Alonso-Ferrero ME, Río P, Pujol MR, Casado JA, Pérez L, Jacome A, Agirre X, Calasanz MJ, Hanenberg H, Surrallés J, Prosper F, Albella B, Bueren JA
PLoS One. 2010
PubMed ID: 21203397
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Mutation of ARHGAP9 in patients with coronary spastic angina.
Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K
J Hum Genet. 2010
PubMed ID: 19911011
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Transglutaminase 2 regulates the GTPase-activating activity of Bcr.
Yi SJ, Groffen J, Heisterkamp N
J Biol Chem. 2009
PubMed ID: 19840940
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Frequency of BCR-ABL gene mutations in Polish patients with chronic myeloid leukemia treated with imatinib: a final report of the MAPTEST study.
Lewandowski K, Warzocha K, Hellmann A, Skotnicki A, Prejzner W, Foryciarz K, Sacha T, Gniot M, Majewski M, Solarska I, Nowak G, Wasag B, Kobelski M, Scibiorski C, Siemiatkowski M, Lewandowska M, Komarnicki M
Pol Arch Med Wewn. 2009
PubMed ID: 20010464
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An accurate and rapid flow cytometric diagnosis of BCR-ABL positive acute lymphoblastic leukemia.
Raponi S, De Propris MS, Wai H, Intoppa S, Elia L, Diverio D, Vitale A, Foà R, Guarini A
Haematologica. 2009
PubMed ID: 19608682
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p210(Bcr-Abl) desensitizes Cdc42 GTPase signaling for SDF-1alpha-directed migration in chronic myeloid leukemia cells.
Chang YC, Tien SC, Tien HF, Zhang H, Bokoch GM, Chang ZF
Oncogene. 2009
PubMed ID: 19718053
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Absence of mature peripheral B cell populations in mice with concomitant defects in B cell receptor and BAFF-R signaling.
Hoek KL, Carlesso G, Clark ES, Khan WN
J Immunol. 2009
PubMed ID: 19843948
-
Bcr and Abr cooperate in negatively regulating acute inflammatory responses.
Cunnick JM, Schmidhuber S, Chen G, Yu M, Yi SJ, Cho YJ, Kaartinen V, Minoo P, Warburton D, Groffen J, Heisterkamp N
Mol Cell Biol. 2009
PubMed ID: 19703997
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DNA vaccination against bcr-abl-positive cells in mice.
Lucansky V, Sobotkova E, Tachezy R, Duskova M, Vonka V
Int J Oncol. 2009
PubMed ID: 19724931
-
Determining the rise in BCR-ABL RNA that optimally predicts a kinase domain mutation in patients with chronic myeloid leukemia on imatinib.
Press RD, Willis SG, Laudadio J, Mauro MJ, Deininger MW
Blood. 2009
PubMed ID: 19625707
-
Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase.
Hughes T, Saglio G, Branford S, Soverini S, Kim DW, Müller MC, Martinelli G, Cortes J, Beppu L, Gottardi E, Kim D, Erben P, Shou Y, Haque A, Gallagher N, Radich J, Hochhaus A
J Clin Oncol. 2009
PubMed ID: 19652056
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Antigen receptor signals rescue B cells from TLR tolerance.
Poovassery JS, Vanden Bush TJ, Bishop GA
J Immunol. 2009
PubMed ID: 19648281
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The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL.
Mian AA, Schüll M, Zhao Z, Oancea C, Hundertmark A, Beissert T, Ottmann OG, Ruthardt M
Leukemia. 2009
PubMed ID: 19369965
-
BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair.
Fernandes MS, Reddy MM, Gonneville JR, DeRoo SC, Podar K, Griffin JD, Weinstock DM, Sattler M
Blood. 2009
PubMed ID: 19571320
-
Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms.
Hirano I, Nakamura S, Yokota D, Ono T, Shigeno K, Fujisawa S, Shinjo K, Ohnishi K
J Biol Chem. 2009
PubMed ID: 19261608
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Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
-
CD19 signaling is impaired in murine peritoneal and splenic B-1 B lymphocytes.
Dasu T, Sindhava V, Clarke SH, Bondada S
Mol Immunol. 2009
PubMed ID: 19541367
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Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway.
Naughton R, Quiney C, Turner SD, Cotter TG
Leukemia. 2009
PubMed ID: 19295548
-
Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
-
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
-
Initiation of antigen receptor-dependent differentiation into plasma cells by calmodulin inhibition of E2A.
Hauser J, Verma-Gaur J, Wallenius A, Grundström T
J Immunol. 2009
PubMed ID: 19553523
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New mutations detected by denaturing high performance liquid chromatography during screening of exon 6 bcr-abl mutations in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors.
Mascarenhas CC, Cunha AF, Miranda EC, Zulli R, Silveira RA, Costa FF, Pagnano KB, De Souza CA
Leuk Lymphoma. 2009
PubMed ID: 19557636
-
Sensitization of imatinib-resistant CML cells to TRAIL-induced apoptosis is mediated through down-regulation of Bcr-Abl as well as c-FLIP.
Park SJ, Kim MJ, Kim HB, Kang CD, Kim SH
Biochem J. 2009
PubMed ID: 19203346
-
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
-
Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation.
Shi X, Jin Y, Cheng C, Zhang H, Zou W, Zheng Q, Lu Z, Chen Q, Lai Y, Pan J
Clin Cancer Res. 2009
PubMed ID: 19240172
-
Expression of P190 and P210 BCR/ABL1 in normal human CD34(+) cells induces similar gene expression profiles and results in a STAT5-dependent expansion of the erythroid lineage.
Järås M, Johnels P, Agerstam H, Lassen C, Rissler M, Edén P, Cammenga J, Olofsson T, Bjerrum OW, Richter J, Fan X, Fioretos T
Exp Hematol. 2009
PubMed ID: 19135771
-
Is p190 bcr-abl rearrangement necessary for acute transformation in some p210 CML of childhood?
Scrideli CA, de Oliveira FM, Brassesco MS, de Paula Queiroz R, Bernardes JE, Valera ET, Tone LG
Leuk Res. 2009
PubMed ID: 18495245
-
Molecular biology of bcr-abl1-positive chronic myeloid leukemia.
Quintás-Cardama A, Cortes J
Blood. 2009
PubMed ID: 18827185
-
FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation.
Crowley JE, Stadanlick JE, Cambier JC, Cancro MP
Blood. 2009
PubMed ID: 18791164
-
Correlation of BCR/ABL transcript variants with patients' characteristics in childhood chronic myeloid leukaemia.
Adler R, Viehmann S, Kuhlisch E, Martiniak Y, Röttgers S, Harbott J, Suttorp M
Eur J Haematol. 2009
PubMed ID: 19067742
-
BCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold.
Dierov J, Sanchez PV, Burke BA, Padilla-Nash H, Putt ME, Ried T, Carroll M
Leukemia. 2009
PubMed ID: 19020542
-
Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.
Masuda T, Kai N, Sakuma C, Kobayashi K, Koga H, Yaginuma H
Brain Res. 2009
PubMed ID: 19026994
-
Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells.
Alexis JD, Wang N, Che W, Lerner-Marmarosh N, Sahni A, Korshunov VA, Zou Y, Ding B, Yan C, Berk BC, Abe J
Circ Res. 2009
PubMed ID: 19023129
-
Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment.
Zheng X, Oancea C, Henschler R, Moore MA, Ruthardt M
PLoS One. 2009
PubMed ID: 19876398
-
A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice.
Johnson KJ, Griswold IJ, O'Hare T, Corbin AS, Loriaux M, Deininger MW, Druker BJ
PLoS One. 2009
PubMed ID: 19823681
-
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
-
A novel chalcone derivative which acts as a microtubule depolymerising agent and an inhibitor of P-gp and BCRP in in-vitro and in-vivo glioblastoma models.
Boumendjel A, McLeer-Florin A, Champelovier P, Allegro D, Muhammad D, Souard F, Derouazi M, Peyrot V, Toussaint B, Boutonnat J
BMC Cancer. 2009
PubMed ID: 19619277
-
BCR-ABL fusion transcript types and levels and their interaction with secondary genetic changes in determining the phenotype of Philadelphia chromosome-positive leukemias.
Jones D, Luthra R, Cortes J, Thomas D, O'Brien S, Bueso-Ramos C, Hai S, Ravandi F, de Lima M, Kantarjian H, Jorgensen JL
Blood. 2008
PubMed ID: 18809762
-
Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis.
Shah NP, Kasap C, Weier C, Balbas M, Nicoll JM, Bleickardt E, Nicaise C, Sawyers CL
Cancer Cell. 2008
PubMed ID: 19061839
-
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
-
Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases.
De Keersmaecker K, Versele M, Cools J, Superti-Furga G, Hantschel O
Leukemia. 2008
PubMed ID: 18784740
-
An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259.
Pene-Dumitrescu T, Peterson LF, Donato NJ, Smithgall TE
Oncogene. 2008
PubMed ID: 18794796
-
Detection of BCR-ABL gene mutations in Philadelphia chromosome positive leukemia patients resistant to STI-571 cancer therapy.
Chien JH, Tang JL, Chen RL, Li CC, Lee CP
Leuk Res. 2008
PubMed ID: 18603297
-
Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1.
Yi SJ, Lee HT, Groffen J, Heisterkamp N
Int J Mol Med. 2008
PubMed ID: 18813851
-
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
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Suppression of E-protein activity interferes with the development of BCR-ABL-mediated myeloproliferative disease.
Ko J, Patel N, Ikawa T, Kawamoto H, Frank O, Rivera RR, Van Etten RA, Murre C
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18725623
-
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells.
Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA
J Clin Invest. 2008
PubMed ID: 18704194
-
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
-
Analysis of gene rearrangements using a fluorescence in situ hybridization method in Mexican patients with acute lymphoblastic leukemia: experience at a single institution.
Pérez-Vera P, Salas C, Montero-Ruiz O, Frías S, Dehesa G, Jarquín B, Rivera-Luna R
Cancer Genet Cytogenet. 2008
PubMed ID: 18617057
-
ABL single nucleotide polymorphisms may masquerade as BCR-ABL mutations associated with resistance to tyrosine kinase inhibitors in CML patients.
Ernst T, Hoffmann J, Erben P, Hanfstein B, Leitner A, Hehlmann R, Hochhaus A, Müller MC
Haematologica. 2008
PubMed ID: 18603549
-
Bcr-Abl induces autocrine IGF-1 signaling.
Lakshmikuttyamma A, Pastural E, Takahashi N, Sawada K, Sheridan DP, DeCoteau JF, Geyer CR
Oncogene. 2008
PubMed ID: 18246120
-
[Polymorphisms in the breakpoint cluster region of bcr gene.]
Tian H, Zhou SY
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008
PubMed ID: 18549649
-
Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression.
Bueno MJ, Pérez de Castro I, Gómez de Cedrón M, Santos J, Calin GA, Cigudosa JC, Croce CM, Fernández-Piqueras J, Malumbres M
Cancer Cell. 2008
PubMed ID: 18538733
-
A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia.
Cirmena G, Aliano S, Fugazza G, Bruzzone R, Garuti A, Bocciardi R, Bacigalupo A, Ravazzolo R, Ballestrero A, Sessarego M
Cancer Genet Cytogenet. 2008
PubMed ID: 18503828
-
Activity of a novel Aurora kinase inhibitor against the T315I mutant form of BCR-ABL: in vitro and in vivo studies.
Akahane D, Tauchi T, Okabe S, Nunoda K, Ohyashiki K
Cancer Sci. 2008
PubMed ID: 18429956
-
Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism.
Zhang H, Trachootham D, Lu W, Carew J, Giles FJ, Keating MJ, Arlinghaus RB, Huang P
Leukemia. 2008
PubMed ID: 18385754
-
Characterization of BCR-ABL deletion mutants from patients with chronic myeloid leukemia.
Sherbenou DW, Hantschel O, Turaga L, Kaupe I, Willis S, Bumm T, Press RD, Superti-Furga G, Druker BJ, Deininger MW
Leukemia. 2008
PubMed ID: 18354488
-
BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor.
Tao WJ, Lin H, Sun T, Samanta AK, Arlinghaus R
Oncogene. 2008
PubMed ID: 18071309
-
BCR expression is decreased in meningiomas showing loss of heterozygosity of 22q within a new minimal deletion region.
Wozniak K, Piaskowski S, Gresner SM, Golanska E, Bieniek E, Bigoszewska K, Sikorska B, Szybka M, Kulczycka-Wojdala D, Zakrzewska M, Zawlik I, Papierz W, Stawski R, Jaskolski DJ, Och W, Sieruta M, Liberski PP, Rieske P
Cancer Genet Cytogenet. 2008
PubMed ID: 18474292
-
Many sequence variants affecting diversity of adult human height.
Gudbjartsson DF, Walters GB, Thorleifsson G, Stefansson H, Halldorsson BV, Zusmanovich P, Sulem P, Thorlacius S, Gylfason A, Steinberg S, Helgadottir A, Ingason A, Steinthorsdottir V, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Borch-Johnsen K, Hansen T, Andersen G, Jorgensen T, Pedersen O, Aben KK, Witjes JA, Swinkels DW, den Heijer M, Franke B, Verbeek AL, Becker DM, Yanek LR, Becker LC, Tryggvadottir L, Rafnar T, Gulcher J, Kiemeney LA, Kong A, Thorsteinsdottir U, Stefansson K
Nat Genet. 2008
PubMed ID: 18391951
-
Requirement of c-Myb for p210(BCR/ABL)-dependent transformation of hematopoietic progenitors and leukemogenesis.
Lidonnici MR, Corradini F, Waldron T, Bender TP, Calabretta B
Blood. 2008
PubMed ID: 18227349
-
Suppression of interferon (IFN)-inducible genes and IFN-mediated functional responses in BCR-ABL-expressing cells.
Katsoulidis E, Sassano A, Majchrzak-Kita B, Carayol N, Yoon P, Jordan A, Druker BJ, Fish EN, Platanias LC
J Biol Chem. 2008
PubMed ID: 18287094
-
Deletions adjacent to BCR and ABL1 breakpoints occur in a substantial minority of chronic myeloid leukemia patients with masked Philadelphia rearrangements.
De Melo VA, Milojkovic D, Marin D, Apperley JF, Nacheva EP, Reid AG
Cancer Genet Cytogenet. 2008
PubMed ID: 18406872
-
Mechanisms of genesis of variant translocation in chronic myeloid leukemia are not correlated with ABL1 or BCR deletion status or response to imatinib therapy.
Richebourg S, Eclache V, Perot C, Portnoi MF, Van den Akker J, Terré C, Maareck O, Soenen V, Viguié F, Laï JL, Andrieux J, Corm S, Roche-Lestienne C, Fi-LMC Group
Cancer Genet Cytogenet. 2008
PubMed ID: 18406870
-
BCR/ABL expression of myeloid progenitors increases beta1-integrin mediated adhesion to stromal cells.
Fierro FA, Taubenberger A, Puech PH, Ehninger G, Bornhauser M, Muller DJ, Illmer T
J Mol Biol. 2008
PubMed ID: 18313694
-
Kinase domain mutants of Bcr enhance Bcr-Abl oncogenic effects.
Perazzona B, Lin H, Sun T, Wang Y, Arlinghaus R
Oncogene. 2008
PubMed ID: 17934518
-
BCR-ABL mutants spread resistance to non-mutated cells through a paracrine mechanism.
Liu J, Joha S, Idziorek T, Corm S, Hetuin D, Philippe N, Preudhomme C, Quesnel B
Leukemia. 2008
PubMed ID: 18216868
-
A multiplex PCR for improved detection of typical and atypical BCR-ABL fusion transcripts.
Burmeister T, Reinhardt R
Leuk Res. 2008
PubMed ID: 17928051
-
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR
J Proteome Res. 2008
PubMed ID: 18220336
-
Expression of BCR-ABL1 oncogene relative to ABL1 gene changes overtime in chronic myeloid leukemia.
Gupta M, Milani L, Hermansson M, Simonsson B, Markevärn B, Syvänen AC, Barbany G
Biochem Biophys Res Commun. 2008
PubMed ID: 18082628
-
Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor.
Kweon SM, Cho YJ, Minoo P, Groffen J, Heisterkamp N
J Biol Chem. 2008
PubMed ID: 18070886
-
Phosphoproteome of resting human platelets.
Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schütz C, Walter U, Gambaryan S, Sickmann A
J Proteome Res. 2008
PubMed ID: 18088087
-
Analysis and comparison of clinicohematological parameters and molecular and cytogenetic response of two Bcr/Abl fusion transcripts.
Polampalli S, Choughule A, Negi N, Shinde S, Baisane C, Amre P, Subramanian PG, Gujral S, Prabhash K, Parikh P
Genet Mol Res. 2008
PubMed ID: 19048492
-
A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder.
Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Takeda M, Kunugi H, Koyama T
Prog Neuropsychopharmacol Biol Psychiatry. 2008
PubMed ID: 17822820
-
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
-
Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
Cao L, Yu K, Banh C, Nguyen V, Ritz A, Raphael BJ, Kawakami Y, Kawakami T, Salomon AR
J Immunol. 2007
PubMed ID: 17947660
-
Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells.
Wang L, O'Leary H, Fortney J, Gibson LF
Blood. 2007
PubMed ID: 17638851
-
Bim regulates BCR-induced entry of B cells into the cell cycle.
Craxton A, Draves KE, Clark EA
Eur J Immunol. 2007
PubMed ID: 17705137
-
The immunogenicity of Bcr-Abl expressing dendritic cells is dependent on the Bcr-Abl kinase activity and dominated by Bcr-Abl regulated antigens.
Scheich F, Duyster J, Peschel C, Bernhard H
Blood. 2007
PubMed ID: 17579186
-
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
-
Identification of a novel e8/a4 BCR/ABL fusion transcript in a case of a transformed Sézary syndrome.
Callet-Bauchu E, Salles G, Gazzo S, Dalle S, Berger F, Hayette S
Haematologica. 2007
PubMed ID: 17768128
-
Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency.
Shah NP, Skaggs BJ, Branford S, Hughes TP, Nicoll JM, Paquette RL, Sawyers CL
J Clin Invest. 2007
PubMed ID: 17710227
-
Expression of the p210BCR-ABL oncoprotein drives centrosomal hypertrophy and clonal evolution in human U937 cells.
Giehl M, Fabarius A, Frank O, Erben P, Zheng C, Hafner M, Hochhaus A, Hehlmann R, Seifarth W
Leukemia. 2007
PubMed ID: 17597804
-
Frequency of BCR-ABL fusion oncogene in Pakistani childhood acute lymphoid leukemia (ALL) patients reflects ethnic differences in molecular genetics of ALL.
Iqbal Z, Iqbal M, Akhter T
J Pediatr Hematol Oncol. 2007
PubMed ID: 17762503
-
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.
Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B
Mol Cell. 2007
PubMed ID: 17643375
-
BCR-tyrosine 177 plays an essential role in Ras and Akt activation and in human hematopoietic progenitor transformation in chronic myelogenous leukemia.
Chu S, Li L, Singh H, Bhatia R
Cancer Res. 2007
PubMed ID: 17638918
-
Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling.
Yan M, Luo JK, Ritchie KJ, Sakai I, Takeuchi K, Ren R, Zhang DE
Blood. 2007
PubMed ID: 17374743
-
Role of BCR/ABL gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells.
Modi H, McDonald T, Chu S, Yee JK, Forman SJ, Bhatia R
Blood. 2007
PubMed ID: 17347407
-
Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study.
Ray A, Cowan-Jacob SW, Manley PW, Mestan J, Griffin JD
Blood. 2007
PubMed ID: 17303698
-
Expression of CCL9/MIP-1gamma is repressed by BCR/ABL and its restoration suppresses in vivo leukemogenesis of 32D-BCR/ABL cells.
Iotti G, Ferrari-Amorotti G, Rosafio C, Corradini F, Lidonnici MR, Ronchetti M, Bardini M, Zhang Y, Martinez R, Blasi F, Calabretta B
Oncogene. 2007
PubMed ID: 17160016
-
Upregulation of the TGFbeta signalling pathway by Bcr-Abl: implications for haemopoietic cell growth and chronic myeloid leukaemia.
Møller GM, Frost V, Melo JV, Chantry A
FEBS Lett. 2007
PubMed ID: 17349636
-
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
-
aCGH local copy number aberrations associated with overall copy number genomic instability in colorectal cancer: coordinate involvement of the regions including BCR and ABL.
Bartos JD, Gaile DP, McQuaid DE, Conroy JM, Darbary H, Nowak NJ, Block A, Petrelli NJ, Mittelman A, Stoler DL, Anderson GR
Mutat Res. 2007
PubMed ID: 17196995
-
Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages.
Cho YJ, Cunnick JM, Yi SJ, Kaartinen V, Groffen J, Heisterkamp N
Mol Cell Biol. 2007
PubMed ID: 17116687
-
Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1.
Yoshida C, Yoshida F, Sears DE, Hart SM, Ikebe D, Muto A, Basu S, Igarashi K, Melo JV
Blood. 2007
PubMed ID: 17018862
-
Expression of a bcr-1 isoform of RARalpha-PML does not affect the penetrance of acute promyelocytic leukemia or the acquisition of an interstitial deletion on mouse chromosome 2.
Walter MJ, Ries RE, Armstrong JR, Park JS, Mardis ER, Ley TJ
Blood. 2007
PubMed ID: 17008533
-
Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.
Koch HB, Zhang R, Verdoodt B, Bailey A, Zhang CD, Yates JR, Menssen A, Hermeking H
Cell Cycle. 2007
PubMed ID: 17314511
-
Immunohistochemical study of N-epsilon-carboxymethyl lysine (CML) in human brain: relation to vascular dementia.
Southern L, Williams J, Esiri MM
BMC Neurol. 2007
PubMed ID: 17939855
-
Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs.
Kostenko EV, Olabisi OO, Sahay S, Rodriguez PL, Whitehead IP
Mol Cell Biol. 2006
PubMed ID: 17000758
-
Detection in primary chronic myeloid leukaemia cells of p210BCR-ABL1 in complexes with adaptor proteins CBL, CRKL, and GRB2.
Patel H, Marley SB, Gordon MY
Genes Chromosomes Cancer. 2006
PubMed ID: 16955467
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The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells.
Aichberger KJ, Mayerhofer M, Vales A, Krauth MT, Gleixner KV, Bilban M, Esterbauer H, Sonneck K, Florian S, Derdak S, Pickl WF, Agis H, Falus A, Sillaber C, Valent P
Blood. 2006
PubMed ID: 16849647
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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
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Comprehensive analysis of BCR-ABL transcript types in Korean CML patients using a newly developed multiplex RT-PCR.
Goh HG, Hwang JY, Kim SH, Lee YH, Kim YL, Kim DW
Transl Res. 2006
PubMed ID: 17145570
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Molecular profiling of chronic myeloid leukemia in eastern India.
Mondal BC, Bandyopadhyay A, Majumdar S, Mukhopadhyay A, Chandra S, Chaudhuri U, Chakrabarti P, Bhattacharyya S, Dasgupta UB
Am J Hematol. 2006
PubMed ID: 16888785
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Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity.
Meyn MA, Wilson MB, Abdi FA, Fahey N, Schiavone AP, Wu J, Hochrein JM, Engen JR, Smithgall TE
J Biol Chem. 2006
PubMed ID: 16912036
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Detection and quantification of the abelson tyrosine kinase domains of the BCR-ABL gene translocation in chronic myeloid leukaemia using genomic quantitative real-time polymerase chain reaction.
Gullo CA, Chuah CT, Hwang WY, Teoh GK
Ann Acad Med Singapore. 2006
PubMed ID: 17102890
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Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells.
Krause DS, Lazarides K, von Andrian UH, Van Etten RA
Nat Med. 2006
PubMed ID: 16998483
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Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate.
Jabbour E, Kantarjian H, Jones D, Talpaz M, Bekele N, O'Brien S, Zhou X, Luthra R, Garcia-Manero G, Giles F, Rios MB, Verstovsek S, Cortes J
Leukemia. 2006
PubMed ID: 16855631
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Adaphostin and bortezomib induce oxidative injury and apoptosis in imatinib mesylate-resistant hematopoietic cells expressing mutant forms of Bcr/Abl.
Dasmahapatra G, Nguyen TK, Dent P, Grant S
Leuk Res. 2006
PubMed ID: 16481037
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Absence of the JAK2 mutation V617F in CD34+ hematopoietic stem and progenitor cells from patients with BCR-ABL-positive CML in chronic phase and blast crisis.
Kronenwett R, Gräf T, Neumann F, Pechtel S, Steidl U, Diaz-Blanco E, Haas R
Leuk Res. 2006
PubMed ID: 16442619
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A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation.
McCallum L, Price S, Planque N, Perbal B, Pierce A, Whetton AD, Irvine AE
Blood. 2006
PubMed ID: 16670264
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Distinct biological impact of dephosphorylation vs. downregulation of p210Bcr-Abl: implications for imatinib mesylate response and resistance.
Kurzrock R, Talpaz M, Li L, Estrov Z
Leuk Lymphoma. 2006
PubMed ID: 16966279
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A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands.
Giallourakis C, Cao Z, Green T, Wachtel H, Xie X, Lopez-Illasaca M, Daly M, Rioux J, Xavier R
Genome Res. 2006
PubMed ID: 16825666
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Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression.
Nakanishi T, Shiozawa K, Hassel BA, Ross DD
Blood. 2006
PubMed ID: 16543472
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Bcr interacts with components of the endosomal sorting complex required for transport-I and is required for epidermal growth factor receptor turnover.
Olabisi OO, Mahon GM, Kostenko EV, Liu Z, Ozer HL, Whitehead IP
Cancer Res. 2006
PubMed ID: 16778200
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Generation of the BCR/ABL fusion gene in a Philadelphia chromosome-negative chronic myeloid leukaemia: insertion of 5.6 Mb of 9q34 into the BCR region of chromosome 22.
Valle L, Fernández V, Pérez-Pons C, Sánchez FG, Benítez J, Urioste M
Hematol Oncol. 2006
PubMed ID: 16598834
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Bcr-Abl reduces endoplasmic reticulum releasable calcium levels by a Bcl-2-independent mechanism and inhibits calcium-dependent apoptotic signaling.
Piwocka K, Vejda S, Cotter TG, O'Sullivan GC, McKenna SL
Blood. 2006
PubMed ID: 16469868
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Serial measurement of BCR-ABL transcripts in the peripheral blood after allogeneic stem cell transplantation for chronic myeloid leukemia: an attempt to define patients who may not require further therapy.
Kaeda J, O'Shea D, Szydlo RM, Olavarria E, Dazzi F, Marin D, Saunders S, Khorashad JS, Cross NC, Goldman JM, Apperley JF
Blood. 2006
PubMed ID: 16449534
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Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells.
Guerzoni C, Bardini M, Mariani SA, Ferrari-Amorotti G, Neviani P, Panno ML, Zhang Y, Martinez R, Perrotti D, Calabretta B
Blood. 2006
PubMed ID: 16418324
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Quantitative real-time RT-PCR monitoring of BCR-ABL in chronic myelogenous leukemia shows lack of agreement in blood and bone marrow samples.
Stock W, Yu D, Karrison T, Sher D, Stone RM, Larson RA, Bloomfield CD
Int J Oncol. 2006
PubMed ID: 16596225
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Identification of transcriptional targets associated with the expression of p210 Bcr-Abl.
Hickey FB, Cotter TG
Eur J Haematol. 2006
PubMed ID: 16494625
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A Ph-negative chronic myeloid leukemia with a complex BCR/ABL rearrangement and a t(6;9)(p21;q34.1).
Todorić-Zivanović B, Marisavljević D, Surace C, Cemerikić V, Marković O, Krtolica K, Tatomirović Z, Cikota B, Magić Z, Rocchi M
Cancer Genet Cytogenet. 2006
PubMed ID: 16631477
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Bcr interferes with beta-catenin-Tcf1 interaction.
Ress A, Moelling K
FEBS Lett. 2006
PubMed ID: 16442529
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BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells.
Slupianek A, Nowicki MO, Koptyra M, Skorski T
DNA Repair (Amst). 2006
PubMed ID: 16297667
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The Philadelphia chromosome as a secondary abnormality in inv(3)(q21q26) acute myeloid leukemia at diagnosis: confirmation of p190 BCR-ABL mRNA by real-time quantitative polymerase chain reaction.
Han JY, Theil KS
Cancer Genet Cytogenet. 2006
PubMed ID: 16490599
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BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility.
Zheng X, Güller S, Beissert T, Puccetti E, Ruthardt M
BMC Cancer. 2006
PubMed ID: 17090304
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Natural history of Southeast Asian chronic myeloid leukemia patients with different BCR-ABL gene variants.
Auewarakul CU, Huang S, Yimyam M, Boonmoh S
Acta Haematol. 2006
PubMed ID: 16914906
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Deletion of the derivative chromosome 9 in chronic myeloid leukemia.
Campbell LJ
Methods Mol Med. 2006
PubMed ID: 16502580
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Detection of BCR-ABL mutations and resistance to imatinib mesylate.
Branford S, Hughes T
Methods Mol Med. 2006
PubMed ID: 16502579
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A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake.
Devireddy LR, Gazin C, Zhu X, Green MR
Cell. 2005
PubMed ID: 16377569
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Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate.
Skalet AH, Isler JA, King LB, Harding HP, Ron D, Monroe JG
J Biol Chem. 2005
PubMed ID: 16188879
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Detection of single nucleotide insertion of BCR/ABL region in imatinib-resistant human myelogenous leukemia SR-1 cells.
Park TH, Kwon HC, Kim HJ, Han JY, Jeong JS, Han HY, Seo C, Kwak JY, Park JI
Exp Mol Med. 2005
PubMed ID: 16264277
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A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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e6a2 BCR/ABL1 fusion with cryptic der(9)t(9;22) deletions in a patient with chronic myeloid leukemia.
Roti G, La Starza R, Gorello P, Gottardi E, Crescenzi B, Martelli MF, Mecucci C
Haematologica. 2005
PubMed ID: 16079118
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BCR kinase phosphorylates 14-3-3 Tau on residue 233.
Clokie SJ, Cheung KY, Mackie S, Marquez R, Peden AH, Aitken A
FEBS J. 2005
PubMed ID: 16045749
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Bcr-Abl regulates osteopontin transcription via Ras, PI-3K, aPKC, Raf-1, and MEK.
Hickey FB, England K, Cotter TG
J Leukoc Biol. 2005
PubMed ID: 15857938
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[Role of molecular screening for common fusion genes in the diagnosis and classification of leukemia]
Zhu YL, Zhang Y, Zhu P, Yang Y, Du JW, Liu J
Beijing Da Xue Xue Bao. 2005
PubMed ID: 15968309
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The breakpoint cluster region gene on chromosome 22q11 is associated with bipolar disorder.
Hashimoto R, Okada T, Kato T, Kosuga A, Tatsumi M, Kamijima K, Kunugi H
Biol Psychiatry. 2005
PubMed ID: 15866548
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Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation.
Barnes K, McIntosh E, Whetton AD, Daley GQ, Bentley J, Baldwin SA
Oncogene. 2005
PubMed ID: 15735728
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Bcr-Abl-mediated suppression of normal hematopoiesis in leukemia.
Lin H, Monaco G, Sun T, Ling X, Stephens C, Xie S, Belmont J, Arlinghaus R
Oncogene. 2005
PubMed ID: 15735695
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Interpretation of submicroscopic deletions of the BCR or ABL gene should not depend on extra signal-FISH: problems in interpretation of submicroscopic deletion of the BCR or ABL gene with extra signal-FISH.
Kim YR, Cho HI, Yoon SS, Park S, Kim BK, Lee YK, Chun H, Kim HC, Lee DS
Genes Chromosomes Cancer. 2005
PubMed ID: 15723338
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The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal.
Singh DK, Kumar D, Siddiqui Z, Basu SK, Kumar V, Rao KV
Cell. 2005
PubMed ID: 15851034
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Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides.
Aichberger KJ, Mayerhofer M, Krauth MT, Skvara H, Florian S, Sonneck K, Akgul C, Derdak S, Pickl WF, Wacheck V, Selzer E, Monia BP, Moriggl R, Valent P, Sillaber C
Blood. 2005
PubMed ID: 15626746
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Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr.
Zhou H, Xu Y, Yang Y, Huang A, Wu J, Shi Y
J Biol Chem. 2005
PubMed ID: 15684424
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Derivative chromosome 9 deletions are a significant feature of childhood Philadelphia chromosome positive acute lymphoblastic leukaemia.
Robinson HM, Martineau M, Harris RL, Barber KE, Jalali GR, Moorman AV, Strefford JC, Broadfield ZJ, Cheung KL, Harrison CJ
Leukemia. 2005
PubMed ID: 15716990
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High-throughput mapping of a dynamic signaling network in mammalian cells.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL
Science. 2005
PubMed ID: 15761153
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[Acute lymphoblastic leukemias with aberrations of BCR-ABL genes]
Parovichnikova EN, Savchenko VG, Verniuk MA, Vinogradova OA, Misiurin AV, Vorob'ev IA, Domracheva EV, Tikhonova LIu, Rukavitsyn OA, Rossiev VA, Kliasova GA, Turkina AG, Liubimova LS, Mendeleeva LP, Isaev VG
Ter Arkh. 2005
PubMed ID: 16116902
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Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
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Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release.
Deming PB, Schafer ZT, Tashker JS, Potts MB, Deshmukh M, Kornbluth S
Mol Cell Biol. 2004
PubMed ID: 15542838
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Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3.
Malmberg EK, Andersson CX, Gentzsch M, Chen JH, Mengos A, Cui L, Hansson GC, Riordan JR
J Cell Sci. 2004
PubMed ID: 15494376
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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Second case of CML with aberrant BCR-ABL fusion transcript (e8/a2) with insertion of an inverted ABL intron 1b sequence.
Sugimoto T, Ijima K, Hisatomi H, Murayama T, Mizuno I, Hato A, Imoto S, Nishimura R, Koizumi T
Am J Hematol. 2004
PubMed ID: 15389825
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The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.
Laurent CE, Smithgall TE
Exp Cell Res. 2004
PubMed ID: 15302586
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Fluorescent in situ hybridization analysis of Philadelphia chromosome-negative chronic myeloid leukemia with the bcr/abl fusion gene.
Monma F, Nishii K, Yamamori S, Hosokai N, Nakazaki T, Lorenzo F, Usui E, Sakakura M, Miyashita H, Fujieda A, Ohishi K, Katayama N, Shiku H
Int J Hematol. 2004
PubMed ID: 15481444
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[Polymorphism analysis of 5' promotor region of BCR gene]
Tian H, Zheng WY, Fu YG, Lin JH, Lu FJ, Zhou SY
Ai Zheng. 2004
PubMed ID: 15248918
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Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors.
Kuribara R, Honda H, Matsui H, Shinjyo T, Inukai T, Sugita K, Nakazawa S, Hirai H, Ozawa K, Inaba T
Mol Cell Biol. 2004
PubMed ID: 15226421
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A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase.
Million RP, Harakawa N, Roumiantsev S, Varticovski L, Van Etten RA
Mol Cell Biol. 2004
PubMed ID: 15143164
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Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC
Anal Chem. 2004
PubMed ID: 15144186
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Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays.
Håkansson P, Segal D, Lassen C, Gullberg U, Morse HC, Fioretos T, Meltzer PS
Exp Hematol. 2004
PubMed ID: 15145216
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Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2.
Burchert A, Cai D, Hofbauer LC, Samuelsson MK, Slater EP, Duyster J, Ritter M, Hochhaus A, Müller R, Eilers M, Schmidt M, Neubauer A
Blood. 2004
PubMed ID: 14656881
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
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p210BCR/ABL-induced alteration of pre-mRNA splicing in primary human CD34+ hematopoietic progenitor cells.
Salesse S, Dylla SJ, Verfaillie CM
Leukemia. 2004
PubMed ID: 14961028
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The BCR-ABL1 kinase bypasses selection for the expression of a pre-B cell receptor in pre-B acute lymphoblastic leukemia cells.
Klein F, Feldhahn N, Harder L, Wang H, Wartenberg M, Hofmann WK, Wernet P, Siebert R, Müschen M
J Exp Med. 2004
PubMed ID: 14993251
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Detection of bcr-abl gene expression at a low level in blood cells of some patients with essential thrombocythemia.
Hsu HC, Tan LY, Au LC, Lee YM, Lieu CH, Tsai WH, You JY, Liu MD, Ho CK
J Lab Clin Med. 2004
PubMed ID: 14966468
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Endoplasmic reticulum stress initiates apoptotic death induced by STI571 inhibition of p210 bcr-abl tyrosine kinase.
Pattacini L, Mancini M, Mazzacurati L, Brusa G, Benvenuti M, Martinelli G, Baccarani M, Santucci MA
Leuk Res. 2004
PubMed ID: 14654084
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
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Nat Genet. 2004
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A comprehensive analysis of 22q11 gene expression in the developing and adult brain.
Maynard TM, Haskell GT, Peters AZ, Sikich L, Lieberman JA, LaMantia AS
Proc Natl Acad Sci U S A. 2003
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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Induction of apoptosis by apicidin, a histone deacetylase inhibitor, via the activation of mitochondria-dependent caspase cascades in human Bcr-Abl-positive leukemia cells.
Cheong JW, Chong SY, Kim JY, Eom JI, Jeung HK, Maeng HY, Lee ST, Min YH
Clin Cancer Res. 2003
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Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis.
Puccetti E, Beissert T, Güller S, Li JE, Hoelzer D, Ottmann OG, Ruthardt M
Oncogene. 2003
PubMed ID: 14534537
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Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Okazaki N, Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga Y, Nagase T, Ohara O, Koga H
DNA Res. 2003
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Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.
Jaiswal S, Traver D, Miyamoto T, Akashi K, Lagasse E, Weissman IL
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12890867
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Characterization of a myeloid tyrosine phosphatase, Lyp, and its role in the Bcr-Abl signal transduction pathway.
Chien W, Tidow N, Williamson EA, Shih LY, Krug U, Kettenbach A, Fermin AC, Roifman CM, Koeffler HP
J Biol Chem. 2003
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The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain.
Radziwill G, Erdmann RA, Margelisch U, Moelling K
Mol Cell Biol. 2003
PubMed ID: 12808105
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Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells.
Coppo P, Dusanter-Fourt I, Millot G, Nogueira MM, Dugray A, Bonnet ML, Mitjavila-Garcia MT, Le Pesteur D, Guilhot F, Vainchenker W, Sainteny F, Turhan AG
Oncogene. 2003
PubMed ID: 12821944
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Amplification of the BCR/ABL fusion gene clustered on a masked Philadelphia chromosome in a patient with myeloblastic crisis of chronic myelocytic leukemia.
Gargallo PM, Cuello MT, Aranguren PN, Larripa IB
Cancer Genet Cytogenet. 2003
PubMed ID: 12781448
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Prolonged treatment with imatinib mesylate in patients with advanced chronic myeloid leukemia causes a reduction of bcr/abl mRNA levels independent of cytogenetic response.
Cariani E, Capucci M, Micheletti M, Spalenza F, Zanella I, Albertini A, Rossi G
Ann Hematol. 2003
PubMed ID: 12734675
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The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains.
Stanglmaier M, Warmuth M, Kleinlein I, Reis S, Hallek M
Leukemia. 2003
PubMed ID: 12592324
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BCR-ABL binds to IRS-1 and IRS-1 phosphorylation is inhibited by imatinib in K562 cells.
Traina F, Carvalheira JB, Saad MJ, Costa FF, Saad ST
FEBS Lett. 2003
PubMed ID: 12560071
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Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12522270
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Bcr and Abl interaction: oncogenic activation of c-Abl by sequestering Bcr.
Ling X, Ma G, Sun T, Liu J, Arlinghaus RB
Cancer Res. 2003
PubMed ID: 12543778
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Direct evidence that Bcr-Abl tyrosine kinase activity disrupts normal synergistic interactions between Kit ligand and cytokines in primary primitive progenitor cells.
Strife A, Wisniewski D, Liu C, Lambek CL, Darzynkiewicz Z, Silver RT, Clarkson B
Mol Cancer Res. 2003
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BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging culture system.
Mayotte N, Roy DC, Yao J, Kroon E, Sauvageau G
Blood. 2002
PubMed ID: 12393433
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Jak2 is involved in c-Myc induction by Bcr-Abl.
Xie S, Lin H, Sun T, Arlinghaus RB
Oncogene. 2002
PubMed ID: 12370803
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e19a2-positive chronic myeloid leukaemia with BCR exon e16-deleted transcripts.
Wang L, Seale J, Woodcock BE, Clark RE
Leukemia. 2002
PubMed ID: 12145699
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A 76-kb duplicon maps close to the BCR gene on chromosome 22 and the ABL gene on chromosome 9: possible involvement in the genesis of the Philadelphia chromosome translocation.
Saglio G, Storlazzi CT, Giugliano E, Surace C, Anelli L, Rege-Cambrin G, Zagaria A, Jimenez Velasco A, Heiniger A, Scaravaglio P, Torres Gomez A, Roman Gomez J, Archidiacono N, Banfi S, Rocchi M
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12114534
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p38 MAPK-mediated activation of NF-kappaB by the RhoGEF domain of Bcr.
Korus M, Mahon GM, Cheng L, Whitehead IP
Oncogene. 2002
PubMed ID: 12096337
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Clinical significance of dual color-dual fusion translocation fluorescence in situ hybridization in the detection of bcr/abl fusion gene.
Wu B, Zhou S, Song L, Liu X
Zhonghua Zhong Liu Za Zhi. 2002
PubMed ID: 12408765
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The t(4;22)(q12;q11) in atypical chronic myeloid leukaemia fuses BCR to PDGFRA.
Baxter EJ, Hochhaus A, Bolufer P, Reiter A, Fernandez JM, Senent L, Cervera J, Moscardo F, Sanz MA, Cross NC
Hum Mol Genet. 2002
PubMed ID: 12023981
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A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9.
Dash AB, Williams IR, Kutok JL, Tomasson MH, Anastasiadou E, Lindahl K, Li S, Van Etten RA, Borrow J, Housman D, Druker B, Gilliland DG
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12032333
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Comprehensive comparison of FISH, RT-PCR, and RQ-PCR for monitoring the BCR-ABL gene after hematopoietic stem cell transplantation in CML.
Kim YJ, Kim DW, Lee S, Kim HJ, Kim YL, Hwang JY, Oh IH, Park YH, Lee YK, Min CK, Kim TG, Han TH, Min WS, Kim CC
Eur J Haematol. 2002
PubMed ID: 12144533
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Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway.
Bassermann F, Jahn T, Miething C, Seipel P, Bai RY, Coutinho S, Tybulewicz VL, Peschel C, Duyster J
J Biol Chem. 2002
PubMed ID: 11790798
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Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs.
Kaartinen V, Nagy A, Gonzalez-Gomez I, Groffen J, Heisterkamp N
Dev Dyn. 2002
PubMed ID: 11921339
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Structure of the Bcr-Abl oncoprotein oligomerization domain.
Zhao X, Ghaffari S, Lodish H, Malashkevich VN, Kim PS
Nat Struct Biol. 2002
PubMed ID: 11780146
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Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells.
Jena N, Deng M, Sicinska E, Sicinski P, Daley GQ
Cancer Res. 2002
PubMed ID: 11809706
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Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL.
Fioretos T, Panagopoulos I, Lassen C, Swedin A, Billström R, Isaksson M, Strömbeck B, Olofsson T, Mitelman F, Johansson B
Genes Chromosomes Cancer. 2001
PubMed ID: 11746971
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Abnormal function of astroglia lacking Abr and Bcr RacGAPs.
Kaartinen V, Gonzalez-Gomez I, Voncken JW, Haataja L, Faure E, Nagy A, Groffen J, Heisterkamp N
Development. 2001
PubMed ID: 11684658
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p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells.
Che W, Abe J, Yoshizumi M, Huang Q, Glassman M, Ohta S, Melaragno MG, Poppa V, Yan C, Lerner-Marmarosh N, Zhang C, Wu Y, Arlinghaus R, Berk BC
Circulation. 2001
PubMed ID: 11560856
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Suppressed apoptosis of pre-B cells in bone marrow of pre-leukemic p190bcr/abl transgenic mice.
Yu Q, Brain J, Laneuville P, Osmond DG
Leukemia. 2001
PubMed ID: 11368444
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BCR gene expression blocks Bcr-Abl induced pathogenicity in a mouse model.
Lin F, Monaco G, Sun T, Liu J, Lin H, Stephens C, Belmont J, Arlinghaus RB
Oncogene. 2001
PubMed ID: 11313935
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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Preparation and application of antibodies to phosphoamino acid sequences.
Sun T, Campbell M, Gordon W, Arlinghaus RB
Biopolymers. 2001
PubMed ID: 11376433
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Model mice for BCR/ABL-positive leukemias.
Honda H, Hirai H
Blood Cells Mol Dis. 2001
PubMed ID: 11358387
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Complementary effects of TNF and lymphotoxin on the formation of germinal center and follicular dendritic cells.
Wang Y, Wang J, Sun Y, Wu Q, Fu YX
J Immunol. 2001
PubMed ID: 11123309
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Cytoplasmic and nuclear localization of the 130 and 160 kDa Bcr proteins.
Laurent E, Talpaz M, Wetzler M, Kurzrock R
Leukemia. 2000
PubMed ID: 11069024
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase.
Million RP, Van Etten RA
Blood. 2000
PubMed ID: 10887132
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Characterization of Ggrb4, an adapter protein interacting with Bcr-Abl.
Coutinho S, Jahn T, Lewitzky M, Feller S, Hutzler P, Peschel C, Duyster J
Blood. 2000
PubMed ID: 10887126
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Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck.
Lionberger JM, Wilson MB, Smithgall TE
J Biol Chem. 2000
PubMed ID: 10849448
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The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl.
Lionberger JM, Smithgall TE
Cancer Res. 2000
PubMed ID: 10706130
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The DNA sequence of human chromosome 22.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP
Nature. 1999
PubMed ID: 10591208
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Antigens recognized by autologous antibody in patients with renal-cell carcinoma.
Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ
Int J Cancer. 1999
PubMed ID: 10508479
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Biological consequences of the BCR/ABL fusion gene in humans and mice.
Gordon MY
J Clin Pathol. 1999
PubMed ID: 10674025
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The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues.
Wu Q, Wang Y, Wang J, Hedgeman EO, Browning JL, Fu YX
J Exp Med. 1999
PubMed ID: 10477548
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Growth factor independence and BCR/ABL transformation: promise and pitfalls of murine model systems and assays.
Ghaffari S, Daley GQ, Lodish HF
Leukemia. 1999
PubMed ID: 10450747
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A new mouse insertional mutation that causes sensorineural deafness and vestibular defects.
Alagramam KN, Kwon HY, Cacheiro NL, Stubbs L, Wright CG, Erway LC, Woychik RP
Genetics. 1999
PubMed ID: 10430593
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BCR binds to the xeroderma pigmentosum group B protein.
Maru Y, Kobayashi T, Tanaka K, Shibuya M
Biochem Biophys Res Commun. 1999
PubMed ID: 10403766
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CRKL binding to BCR-ABL and BCR-ABL transformation.
Kolibaba KS, Bhat A, Heaney C, Oda T, Druker BJ
Leuk Lymphoma. 1999
PubMed ID: 10194128
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GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway.
Shi CS, Tuscano JM, Witte ON, Kehrl JH
Blood. 1999
PubMed ID: 9949177
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Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen.
Ngo VN, Korner H, Gunn MD, Schmidt KN, Riminton DS, Cooper MD, Browning JL, Sedgwick JD, Cyster JG
J Exp Med. 1999
PubMed ID: 9892622
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The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein.
Takeda N, Shibuya M, Maru Y
Proc Natl Acad Sci U S A. 1999
PubMed ID: 9874796
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Syp Y279, Y304 Can Mediate the Binding of Bcr-Abl to Grb2 and Other Proteins.
Zhu K, Liu XP, Zeng G, Ye FY
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shangh. 1999
PubMed ID: 12115002
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc.
Liu SK, McGlade CJ
Oncogene. 1998
PubMed ID: 9872323
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Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow.
Pear WS, Miller JP, Xu L, Pui JC, Soffer B, Quackenbush RC, Pendergast AM, Bronson R, Aster JC, Scott ML, Baltimore D
Blood. 1998
PubMed ID: 9808572
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Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product.
Voncken JW, Baram TZ, Gonzales-Gomez I, Van Schaick H, Shih JC, Chen K, Groffen J, Heisterkamp N
Int J Mol Med. 1998
PubMed ID: 9858655
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Regulation of Bcr-Abl-induced SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase.
Liedtke M, Pandey P, Kumar S, Kharbanda S, Kufe D
Oncogene. 1998
PubMed ID: 9788431
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The SH2-containing adapter protein GRB10 interacts with BCR-ABL.
Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J
Oncogene. 1998
PubMed ID: 9747873
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Fine genetic and comparative mapping of the deafness mutation Ames waltzer on mouse chromosome 10.
Zobeley E, Sufalko DK, Adkins S, Burmeister M
Genomics. 1998
PubMed ID: 9653653
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Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo.
LaMontagne KR, Flint AJ, Franza BR, Pandergast AM, Tonks NK
Mol Cell Biol. 1998
PubMed ID: 9566916
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Bcr/Abl associated leukemogenesis in bcr null mutant mice.
Voncken JW, Kaartinen V, Groffen J, Heisterkamp N
Oncogene. 1998
PubMed ID: 9591787
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Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA.
Zhang B, Chernoff J, Zheng Y
J Biol Chem. 1998
PubMed ID: 9535855
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A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation.
Reuther JY, Reuther GW, Cortez D, Pendergast AM, Baldwin AS
Genes Dev. 1998
PubMed ID: 9531535
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Requirement of two specific tyrosine residues for the catalytic activity of Bcr serine/threonine kinase.
Wu Y, Liu J, Arlinghaus RB
Oncogene. 1998
PubMed ID: 9467953
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The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr.
Warmuth M, Bergmann M, Priess A, Häuslmann K, Emmerich B, Hallek M
J Biol Chem. 1997
PubMed ID: 9407116
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A BCR-ABL(p190) fusion gene made by homologous recombination causes B-cell acute lymphoblastic leukemias in chimeric mice with independence of the endogenous bcr product.
Castellanos A, Pintado B, Weruaga E, Arévalo R, López A, Orfao A, Sánchez-García I
Blood. 1997
PubMed ID: 9310467
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Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase.
Ram PA, Waxman DJ
J Biol Chem. 1997
PubMed ID: 9211920
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Bcr phosphorylated on tyrosine 177 binds Grb2.
Ma G, Lu D, Wu Y, Liu J, Arlinghaus RB
Oncogene. 1997
PubMed ID: 9178913
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Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl.
Odai H, Sasaki K, Iwamatsu A, Nakamoto T, Ueno H, Yamagata T, Mitani K, Yazaki Y, Hirai H
Blood. 1997
PubMed ID: 9108392
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P210 Bcr-Abl interacts with the interleukin-3 beta c subunit and constitutively activates Jak2.
Wilson-Rawls J, Liu J, Laneuville P, Arlinghaus RB
Leukemia. 1997
PubMed ID: 9209414
-
Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site.
de Jong R, ten Hoeve J, Heisterkamp N, Groffen J
Oncogene. 1997
PubMed ID: 9053848
-
Interaction of BCR-ABL with the retinoblastoma protein in Philadelphia chromosome-positive cell lines.
Miyamura T, Nishimura J, Yufu Y, Nawata H
Int J Hematol. 1997
PubMed ID: 9071815
-
Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation.
Heaney C, Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, Druker BJ
Blood. 1997
PubMed ID: 8978305
-
Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues.
Li J, Smithgall TE
J Biol Chem. 1996
PubMed ID: 8955135
-
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
-
In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.
Bewarder N, Weinrich V, Budde P, Hartmann D, Flaswinkel H, Reth M, Frey J
Mol Cell Biol. 1996
PubMed ID: 8756631
-
Fine genetic map of mouse chromosome 10 around the polycystic kidney disease gene, jcpk, and ankyrin 3.
Bryda EC, Ling H, Rathbun DE, Burmeister M, Flaherty L
Genomics. 1996
PubMed ID: 8812475
-
Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells.
Hallek M, Danhauser-Riedl S, Herbst R, Warmuth M, Winkler A, Kolb HJ, Druker B, Griffin JD, Emmerich B, Ullrich A
Br J Haematol. 1996
PubMed ID: 8757502
-
Inhibition of Bcr serine kinase by tyrosine phosphorylation.
Liu J, Wu Y, Ma GZ, Lu D, Haataja L, Heisterkamp N, Groffen J, Arlinghaus RB
Mol Cell Biol. 1996
PubMed ID: 8622703
-
p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl.
Salgia R, Sattler M, Pisick E, Li JL, Griffin JD
Exp Hematol. 1996
PubMed ID: 8641358
-
Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells.
Skorski T, Kanakaraj P, Nieborowska-Skorska M, Ratajczak MZ, Wen SC, Zon G, Gewirtz AM, Perussia B, Calabretta B
Blood. 1995
PubMed ID: 7606002
-
Structural characterization and chromosomal location of the mouse macrophage migration inhibitory factor gene and pseudogenes.
Bozza M, Kolakowski LF, Jenkins NA, Gilbert DJ, Copeland NG, David JR, Gerard C
Genomics. 1995
PubMed ID: 7558021
-
Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.
Chissoe SL, Bodenteich A, Wang YF, Wang YP, Burian D, Clifton SW, Crabtree J, Freeman A, Iyer K, Jian L
Genomics. 1995
PubMed ID: 7665185
-
Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10.
Kapfhamer D, Miller DE, Lambert S, Bennett V, Glover TW, Burmeister M
Genomics. 1995
PubMed ID: 7665168
-
Cell cycle-related shifts in subcellular localization of BCR: association with mitotic chromosomes and with heterochromatin.
Wetzler M, Talpaz M, Yee G, Stass SA, Van Etten RA, Andreeff M, Goodacre AM, Kleine HD, Mahadevia RK, Kurzrock R
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7724587
-
Increased neutrophil respiratory burst in bcr-null mutants.
Voncken JW, van Schaick H, Kaartinen V, Deemer K, Coates T, Landing B, Pattengale P, Dorseuil O, Bokoch GM, Groffen J
Cell. 1995
PubMed ID: 7889565
-
Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL.
Salgia R, Li JL, Lo SH, Brunkhorst B, Kansas GS, Sobhany ES, Sun Y, Pisick E, Hallek M, Ernst T
J Biol Chem. 1995
PubMed ID: 7534286
-
Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS.
Maru Y, Peters KL, Afar DE, Shibuya M, Witte ON, Smithgall TE
Mol Cell Biol. 1995
PubMed ID: 7529874
-
Regional localization and developmental expression of the BCR gene in rodent brain.
Fioretos T, Voncken JW, Baram TZ, Kamme F, Groffen J, Heisterkamp N
Cell Mol Biol Res. 1995
PubMed ID: 8581068
-
The natural killer cell serine protease gene Lmet1 maps to mouse chromosome 10.
Thia KY, Jenkins NA, Gilbert DJ, Copeland NG, Smyth MJ
Immunogenetics. 1995
PubMed ID: 7806275
-
Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family.
Reuther GW, Fu H, Cripe LD, Collier RJ, Pendergast AM
Science. 1994
PubMed ID: 7939633
-
Genetic map of the region around grizzled (gr) and mocha (mh) on mouse chromosome 10, homologous to human 19p13.3.
Kapfhamer D, Burmeister M
Genomics. 1994
PubMed ID: 7851892
-
No evidence for genomic imprinting of the human BCR gene.
Fioretos T, Heisterkamp N, Groffen J
Blood. 1994
PubMed ID: 8204871
-
SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase.
Tauchi T, Feng GS, Shen R, Song HY, Donner D, Pawson T, Broxmeyer HE
J Biol Chem. 1994
PubMed ID: 8195176
-
Genomic organization, alternative polyadenylation, and chromosomal localization of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex.
Mallo M, Steingrímsson E, Copeland NG, Jenkins NA, Gridley T
Genomics. 1994
PubMed ID: 7916324
-
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.
Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R, Pawson T
EMBO J. 1994
PubMed ID: 8112292
-
MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues.
Brott BK, Alessandrini A, Largaespada DA, Copeland NG, Jenkins NA, Crews CM, Erikson RL
Cell Growth Differ. 1993
PubMed ID: 8297798
-
DNA sequence analysis of the major breakpoint cluster region of the BCR gene rearranged in Philadelphia-positive human leukemias.
Sowerby SJ, Kennedy MA, Fitzgerald PH, Morris CM
Oncogene. 1993
PubMed ID: 8502487
-
Duplication of small segments within the major breakpoint cluster region in chronic myelogenous leukemia.
Litz CE, McClure JS, Copenhaver CM, Brunning RD
Blood. 1993
PubMed ID: 8453102
-
A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.
Muller AJ, Pendergast AM, Havlik MH, Puil L, Pawson T, Witte ON
Mol Cell Biol. 1992
PubMed ID: 1383690
-
Amplification and sequencing of genomic breakpoints located within the M-bcr region by Vectorette-mediated polymerase chain reaction.
Mills KI, Sproul AM, Ogilvie D, Elvin P, Leibowitz D, Burnett AK
Leukemia. 1992
PubMed ID: 1317490
-
Evolution of the mammalian G protein alpha subunit multigene family.
Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI
Nat Genet. 1992
PubMed ID: 1302014
-
Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping.
Haefliger JA, Bruzzone R, Jenkins NA, Gilbert DJ, Copeland NG, Paul DL
J Biol Chem. 1992
PubMed ID: 1370487
-
Locating protein-coding regions in human DNA sequences by a multiple sensor-neural network approach.
Uberbacher EC, Mural RJ
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1763041
-
The BCR gene encodes a novel serine/threonine kinase activity within a single exon.
Maru Y, Witte ON
Cell. 1991
PubMed ID: 1657398
-
Entire ABL gene is joined with 5'-BCR in some patients with Philadelphia-positive leukemia.
Morris CM, Heisterkamp N, Groffen J, Fitzgerald PH
Blood. 1991
PubMed ID: 1868241
-
BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner.
Pendergast AM, Muller AJ, Havlik MH, Maru Y, Witte ON
Cell. 1991
PubMed ID: 1712671
-
Bcr encodes a GTPase-activating protein for p21rac.
Diekmann D, Brill S, Garrett MD, Totty N, Hsuan J, Monfries C, Hall C, Lim L, Hall A
Nature. 1991
PubMed ID: 1903516
-
Characterization of the BCR promoter in Philadelphia chromosome-positive and -negative cell lines.
Shah NP, Witte ON, Denny CT
Mol Cell Biol. 1991
PubMed ID: 1900918
-
Reconstruction and analysis of human Alu genes.
Jurka J, Milosavljevic A
J Mol Evol. 1991
PubMed ID: 1706781
-
Unique organization of the human BCR gene promoter.
Zhu QS, Heisterkamp N, Groffen J
Nucleic Acids Res. 1990
PubMed ID: 2263470
-
A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross.
Justice MJ, Siracusa LD, Gilbert DJ, Heisterkamp N, Groffen J, Chada K, Silan CM, Copeland NG, Jenkins NA
Genetics. 1990
PubMed ID: 1975791
-
A novel variant of the bcr-abl fusion product in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Soekarman D, van Denderen J, Hoefsloot L, Moret M, Meeuwsen T, van Baal J, Hagemeijer A, Grosveld G
Leukemia. 1990
PubMed ID: 2193202
-
Chronic myeloid leukemia may be associated with several bcr-abl transcripts including the acute lymphoid leukemia-type 7 kb transcript.
Selleri L, von Lindern M, Hermans A, Meijer D, Torelli G, Grosveld G
Blood. 1990
PubMed ID: 2407300
-
Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation.
Chen SJ, Chen Z, Font MP, d'Auriol L, Larsen CJ, Berger R
Nucleic Acids Res. 1989
PubMed ID: 2678002
-
Alternative 5' end of the bcr-abl transcript in chronic myelogenous leukemia.
Romero P, Beran M, Shtalrid M, Andersson B, Talpaz M, Blick M
Oncogene. 1989
PubMed ID: 2915904
-
The first BCR gene intron contains breakpoints in Philadelphia chromosome positive leukemia.
Heisterkamp N, Knoppel E, Groffen J
Nucleic Acids Res. 1988
PubMed ID: 3194194
-
Duplication of the bcr and gamma-glutamyl transpeptidase genes.
Heisterkamp N, Groffen J
Nucleic Acids Res. 1988
PubMed ID: 2901712
-
Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL).
Clark SS, McLaughlin J, Timmons M, Pendergast AM, Ben-Neriah Y, Dow LW, Crist W, Rovera G, Smith SD, Witte ON
Science. 1988
PubMed ID: 3422516
-
bcr genes and transcripts.
Lifshitz B, Fainstein E, Marcelle C, Shtivelman E, Amson R, Gale RP, Canaani E
Oncogene. 1988
PubMed ID: 3285291
-
A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia.
Fainstein E, Marcelle C, Rosner A, Canaani E, Gale RP, Dreazen O, Smith SD, Croce CM
Nature. 1987
PubMed ID: 2825022
-
Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia.
Hermans A, Heisterkamp N, von Linden M, van Baal S, Meijer D, van der Plas D, Wiedemann LM, Groffen J, Bootsma D, Grosveld G
Cell. 1987
PubMed ID: 2820585
-
Mapping of four distinct BCR-related loci to chromosome region 22q11: order of BCR loci relative to chronic myelogenous leukemia and acute lymphoblastic leukemia breakpoints.
Croce CM, Huebner K, Isobe M, Fainstain E, Lifshitz B, Shtivelman E, Canaani E
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3118359
-
bcr-abl RNA in patients with chronic myelogenous leukemia.
Shtivelman E, Gale RP, Dreazen O, Berrebi A, Zaizov R, Kubonishi I, Miyoshi I, Canaani E
Blood. 1987
PubMed ID: 3101769
-
cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia.
Hariharan IK, Adams JM
EMBO J. 1987
PubMed ID: 3107980
-
Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome.
Mes-Masson AM, McLaughlin J, Daley GQ, Paskind M, Witte ON
Proc Natl Acad Sci U S A. 1986
PubMed ID: 3540951
-
Molecular analysis of both translocation products of a Philadelphia-positive CML patient.
de Klein A, van Agthoven T, Groffen C, Heisterkamp N, Groffen J, Grosveld G
Nucleic Acids Res. 1986
PubMed ID: 3463934
-
The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript.
Grosveld G, Verwoerd T, van Agthoven T, de Klein A, Ramachandran KL, Heisterkamp N, Stam K, Groffen J
Mol Cell Biol. 1986
PubMed ID: 3023859
-
Structural organization of the bcr gene and its role in the Ph' translocation.
Heisterkamp N, Stam K, Groffen J, de Klein A, Grosveld G
Nature. 1985
PubMed ID: 2989703
-
Fused transcript of abl and bcr genes in chronic myelogenous leukaemia.
Shtivelman E, Lifshitz B, Gale RP, Canaani E
Nature. 1985
PubMed ID: 2989692
-
High resolution chromosomes of the t(9;22) positive leukemias.
Prakash O, Yunis JJ
Cancer Genet Cytogenet. 1984
PubMed ID: 6584200
-
Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22.
Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld G
Cell. 1984
PubMed ID: 6319012
-
Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia.
Heisterkamp N, Stephenson JR, Groffen J, Hansen PF, de Klein A, Bartram CR, Grosveld G
Nature. 1983
PubMed ID: 6316147
-
Isolation of human oncogene sequences (v-fes homolog) from a cosmid library.
Groffen J, Heisterkamp N, Grosveld F, Van de Ven W, Stephenson JR
Science. 1982
PubMed ID: 6281890
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