ALX4

Summary Top Help

Gene Description:

aristaless-like homeobox 4; ALX homeobox 4

Synonyms:

ALX4, lst, FND2, Alx4

Orthologs:

Human ALX4 (protein-coding), Mouse Alx4 (protein-coding), Rat Alx4 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:44281994..44331716 (49.72 kb) View in Genome Browser

(Mouse) NCBIM37 - chr2:93482541..93521496 (38.95 kb) View in Genome Browser

(Rat) RGSC3.4 - chr3:78057714..78094285 (36.57 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for ALX4:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
			no data					no data	no data	no data	no data	no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for ALX4:

The ALX4 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
ALX4	MED16	BioGRID	empirical	20211142
ALX4	CDX1	BioGRID	empirical	20211142
ALX4	CDX2	BioGRID	empirical	20211142
ALX4	CDX4	BioGRID	empirical	20211142
ALX4	HOXB13	BioGRID	empirical	20211142
ALX4	CEBPE	BioGRID	empirical	20211142
ALX4	ERCC8	BioGRID	empirical	20211142
ALX4	DLX1	BioGRID	empirical	20211142
ALX4	DLX2	BioGRID	empirical	20211142
ALX4	DLX5	BioGRID	empirical	20211142
ALX4	EMX1	BioGRID	empirical	20211142
ALX4	GATA4	BioGRID	empirical	20211142
ALX4	GTF3C1	BioGRID	empirical	20211142
ALX4	TBX21	BioGRID	empirical	20211142
ALX4	RAX	BioGRID	empirical	20211142
ALX4	FOXA1	BioGRID	empirical	20211142
ALX4	FOXA3	BioGRID	empirical	20211142
ALX4	HOXA3	BioGRID	empirical	20211142
ALX4	HOXA10	BioGRID	empirical	20211142
ALX4	HOXA11	BioGRID	empirical	20211142
ALX4	HOXB6	BioGRID	empirical	20211142
ALX4	HOXC4	BioGRID	empirical	20211142
ALX4	HOXD3	BioGRID	empirical	20211142
ALX4	HOXD12	BioGRID	empirical	20211142
ALX4	HOXD13	BioGRID	empirical	20211142
ALX4	LMX1B	BioGRID	empirical	20211142
ALX4	OTX2	BioGRID	empirical	20211142
ALX4	PAX3	BioGRID	empirical	20211142
ALX4	LEF1	HPRD	empirical	11696550
ALX4	PRRX1	BioGRID	empirical	20211142
ALX4	POU3F4	BioGRID	empirical	20211142
ALX4	POU4F2	BioGRID	empirical	20211142
ALX4	ALX4	BioGRID	empirical	20211142
ALX4	SOX2	BioGRID	empirical	20211142
ALX4	SOX10	HPRD	empirical	16582099
ALX4	SOX15	BioGRID	empirical	20211142
ALX4	TLE6	BioGRID	empirical	20211142
ALX4	ALX1	HPRD	empirical	9847249
ALX4	MIXL1	BioGRID	empirical	20211142
ALX4	LDB1	BioGRID	empirical	20211142
ALX4	FOXH1	BioGRID	empirical	20211142

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 22

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 117

Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb.
Wyngaarden LA, Delgado-Olguin P, Su IH, Bruneau BG, Hopyan S
Development. 2011
PubMed ID: 21795281
Control of pelvic girdle development by genes of the Pbx family and Emx2.
Capellini TD, Handschuh K, Quintana L, Ferretti E, Di Giacomo G, Fantini S, Vaccari G, Clarke SL, Wenger AM, Bejerano G, Sharpe J, Zappavigna V, Selleri L
Dev Dyn. 2011
PubMed ID: 21455939
Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center.
Compagnucci C, Fish JL, Schwark M, Tarabykin V, Depew MJ
Genesis. 2011
PubMed ID: 21309073
Genetic analysis of Hedgehog signaling in ventral body wall development and the onset of omphalocele formation.
Matsumaru D, Haraguchi R, Miyagawa S, Motoyama J, Nakagata N, Meijlink F, Yamada G
PLoS One. 2011
PubMed ID: 21283718
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.
Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL
Gene Expr Patterns. 2011
PubMed ID: 20932939
Impact of single nucleotide polymorphisms and of clinical risk factors on new‐onset diabetes mellitus in HIV‐infected individuals.
Rotger M, Gsponer T, Martinez R, Taffé P, Elzi L, Vernazza P, Cavassini M, Bernasconi E, Hirschel B, Furrer H, Weber R, Ledergerber B, Egger M, Telenti A, Tarr PE, Swiss HIV Cohort Study
Clin Infect Dis. 2010
PubMed ID: 20879858
Twist1 activity thresholds define multiple functions in limb development.
Krawchuk D, Weiner SJ, Chen YT, Lu BC, Costantini F, Behringer RR, Laufer E
Dev Biol. 2010
PubMed ID: 20732316
HoxB2, HoxB4 and Alx4 genes are downregulated in the cadmium-induced omphalocele in the chick model.
Doi T, Puri P, Bannigan J, Thompson J
Pediatr Surg Int. 2010
PubMed ID: 20625746
Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects.
Lakhwani S, García-Sanz P, Vallejo M
Dev Biol. 2010
PubMed ID: 20534379
Mesodermal Tbx1 is required for patterning the proximal mandible in mice.
Aggarwal VS, Carpenter C, Freyer L, Liao J, Petti M, Morrow BE
Dev Biol. 2010
PubMed ID: 20501333
Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1.
Capellini TD, Vaccari G, Ferretti E, Fantini S, He M, Pellegrini M, Quintana L, Di Giacomo G, Sharpe J, Selleri L, Zappavigna V
Development. 2010
PubMed ID: 20627960
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain.
Hammock EA, Eagleson KL, Barlow S, Earls LR, Miller DM, Levitt P
Neural Dev. 2010
PubMed ID: 21122108
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC
PLoS One. 2010
PubMed ID: 20634891
Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.
Galli A, Robay D, Osterwalder M, Bao X, Bénazet JD, Tariq M, Paro R, Mackem S, Zeller R
PLoS Genet. 2010
PubMed ID: 20386744
Performance of epigenetic markers SEPT9 and ALX4 in plasma for detection of colorectal precancerous lesions.
Tänzer M, Balluff B, Distler J, Hale K, Leodolter A, Röcken C, Molnar B, Schmid R, Lofton-Day C, Schuster T, Ebert MP
PLoS One. 2010
PubMed ID: 20140221
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
ALX4 dysfunction disrupts craniofacial and epidermal development.
Kayserili H, Uz E, Niessen C, Vargel I, Alanay Y, Tuncbilek G, Yigit G, Uyguner O, Candan S, Okur H, Kaygin S, Balci S, Mavili E, Alikasifoglu M, Haase I, Wollnik B, Akarsu NA
Hum Mol Genet. 2009
PubMed ID: 19692347
Numb promotes an increase in skeletal muscle progenitor cells in the embryonic somite.
Jory A, Le Roux I, Gayraud-Morel B, Rocheteau P, Cohen-Tannoudji M, Cumano A, Tajbakhsh S
Stem Cells. 2009
PubMed ID: 19785007
Loss of ALX4 expression in epithelial cells and adjacent stromal cells in breast cancer.
Chang H, Mohabir N, Done S, Hamel PA
J Clin Pathol. 2009
PubMed ID: 19783719
Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb.
Lallemand Y, Bensoussan V, Cloment CS, Robert B
Dev Biol. 2009
PubMed ID: 19422820
Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo.
Bildsoe H, Loebel DA, Jones VJ, Chen YT, Behringer RR, Tam PP
Dev Biol. 2009
PubMed ID: 19414008
Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.
Drenos F, Talmud PJ, Casas JP, Smeeth L, Palmen J, Humphries SE, Hingorani AD
Hum Mol Genet. 2009
PubMed ID: 19336475
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud.
Hill P, Götz K, Rüther U
Dev Biol. 2009
PubMed ID: 19248778
FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds.
Zhang Z, Verheyden JM, Hassell JA, Sun X
Dev Cell. 2009
PubMed ID: 19386269
DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis.
Liu N, Barbosa AC, Chapman SL, Bezprozvannaya S, Qi X, Richardson JA, Yanagisawa H, Olson EN
Development. 2009
PubMed ID: 19211672
Rostral and caudal pharyngeal arches share a common neural crest ground pattern.
Minoux M, Antonarakis GS, Kmita M, Duboule D, Rijli FM
Development. 2009
PubMed ID: 19168678
Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling.
Thomason HA, Dixon MJ, Dixon J
Dev Biol. 2008
PubMed ID: 18634775
Dual hindlimb control elements in the Tbx4 gene and region-specific control of bone size in vertebrate limbs.
Menke DB, Guenther C, Kingsley DM
Development. 2008
PubMed ID: 18579682
TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner.
Zhao H, Oka K, Bringas P, Kaartinen V, Chai Y
Dev Biol. 2008
PubMed ID: 18572160
Impaired meningeal development in association with apical expansion of calvarial bone osteogenesis in the Foxc1 mutant.
Vivatbutsiri P, Ichinose S, Hytönen M, Sainio K, Eto K, Iseki S
J Anat. 2008
PubMed ID: 18422524
The apical ectodermal ridge is a timer for generating distal limb progenitors.
Lu P, Yu Y, Perdue Y, Werb Z
Development. 2008
PubMed ID: 18359901
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Smad4 is required to regulate the fate of cranial neural crest cells.
Ko SO, Chung IH, Xu X, Oka S, Zhao H, Cho ES, Deng C, Chai Y
Dev Biol. 2007
PubMed ID: 17964566
The molecular basis of Pallister Hall associated polydactyly.
Hill P, Wang B, Rüther U
Hum Mol Genet. 2007
PubMed ID: 17588959
Genome-wide atlas of gene expression in the adult mouse brain.
Lein ES, Hawrylycz MJ, Ao N, Ayres M, Bensinger A, Bernard A, Boe AF, Boguski MS, Brockway KS, Byrnes EJ, Chen L, Chen L, Chen TM, Chin MC, Chong J, Crook BE, Czaplinska A, Dang CN, Datta S, Dee NR, Desaki AL, Desta T, Diep E, Dolbeare TA, Donelan MJ, Dong HW, Dougherty JG, Duncan BJ, Ebbert AJ, Eichele G, Estin LK, Faber C, Facer BA, Fields R, Fischer SR, Fliss TP, Frensley C, Gates SN, Glattfelder KJ, Halverson KR, Hart MR, Hohmann JG, Howell MP, Jeung DP, Johnson RA, Karr PT, Kawal R, Kidney JM, Knapik RH, Kuan CL, Lake JH, Laramee AR, Larsen KD, Lau C, Lemon TA, Liang AJ, Liu Y, Luong LT, Michaels J, Morgan JJ, Morgan RJ, Mortrud MT, Mosqueda NF, Ng LL, Ng R, Orta GJ, Overly CC, Pak TH, Parry SE, Pathak SD, Pearson OC, Puchalski RB, Riley ZL, Rockett HR, Rowland SA, Royall JJ, Ruiz MJ, Sarno NR, Schaffnit K, Shapovalova NV, Sivisay T, Slaughterbeck CR, Smith SC, Smith KA, Smith BI, Sodt AJ, Stewart NN, Stumpf KR, Sunkin SM, Sutram M, Tam A, Teemer CD, Thaller C, Thompson CL, Varnam LR, Visel A, Whitlock RM, Wohnoutka PE, Wolkey CK, Wong VY, Wood M, Yaylaoglu MB, Young RC, Youngstrom BL, Yuan XF, Zhang B, Zwingman TA, Jones AR
Nature. 2007
PubMed ID: 17151600
Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development.
Britanova O, Depew MJ, Schwark M, Thomas BL, Miletich I, Sharpe P, Tarabykin V
Am J Hum Genet. 2006
PubMed ID: 16960803
Loss of Alx4, a stromally-restricted homeodomain protein, impairs mammary epithelial morphogenesis.
Joshi PA, Chang H, Hamel PA
Dev Biol. 2006
PubMed ID: 16916507
High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts.
Park JW, Cai J, McIntosh I, Jabs EW, Fallin MD, Ingersoll R, Hetmanski JB, Vekemans M, Attie-Bitach T, Lovett M, Scott AF, Beaty TH
J Med Genet. 2006
PubMed ID: 16415175
Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.
Capellini TD, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, Srivastava D, Zappavigna V, Selleri L
Development. 2006
PubMed ID: 16672333
Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT
Hum Mol Genet. 2006
PubMed ID: 16537572
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Enlarged parietal foramina caused by mutations in the homeobox genes ALX4 and MSX2: from genotype to phenotype.
Mavrogiannis LA, Taylor IB, Davies SJ, Ramos FJ, Olivares JL, Wilkie AO
Eur J Hum Genet. 2006
PubMed ID: 16319823
Genetic interaction between Lef1 and Alx4 is required for early embryonic development.
Boras-Granic K, Grosschedl R, Hamel PA
Int J Dev Biol. 2006
PubMed ID: 16892173
The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.
Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M
Nucleic Acids Res. 2006
PubMed ID: 16582099
Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis.
Santagati F, Minoux M, Ren SY, Rijli FM
Development. 2005
PubMed ID: 16221728
FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis.
Li C, Xu X, Nelson DK, Williams T, Kuehn MR, Deng CX
Development. 2005
PubMed ID: 16207751
Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning.
Verheyden JM, Lewandoski M, Deng C, Harfe BD, Sun X
Development. 2005
PubMed ID: 16120640
Function and regulation of Alx4 in limb development: complex genetic interactions with Gli3 and Shh.
Kuijper S, Feitsma H, Sheth R, Korving J, Reijnen M, Meijlink F
Dev Biol. 2005
PubMed ID: 16039644
Threshold-specific requirements for Bmp4 in mandibular development.
Liu W, Selever J, Murali D, Sun X, Brugger SM, Ma L, Schwartz RJ, Maxson R, Furuta Y, Martin JF
Dev Biol. 2005
PubMed ID: 15936012
Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development.
Lallemand Y, Nicola MA, Ramos C, Bach A, Cloment CS, Robert B
Development. 2005
PubMed ID: 15930102
Construction of a natural panel of 11p11.2 deletions and further delineation of the critical region involved in Potocki-Shaffer syndrome.
Wakui K, Gregato G, Ballif BC, Glotzbach CD, Bailey KA, Kuo PL, Sue WC, Sheffield LJ, Irons M, Gomez EG, Hecht JT, Potocki L, Shaffer LG
Eur J Hum Genet. 2005
PubMed ID: 15852040
Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes.
Kuijper S, Beverdam A, Kroon C, Brouwer A, Candille S, Barsh G, Meijlink F
Development. 2005
PubMed ID: 15728667
Genetic interaction of Gli3 and Alx4 during limb development.
Panman L, Drenth T, Tewelscher P, Zuniga A, Zeller R
Int J Dev Biol. 2005
PubMed ID: 15968591
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development.
Selever J, Liu W, Lu MF, Behringer RR, Martin JF
Dev Biol. 2004
PubMed ID: 15581864
Requirement for Mab21l2 during development of murine retina and ventral body wall.
Yamada R, Mizutani-Koseki Y, Koseki H, Takahashi N
Dev Biol. 2004
PubMed ID: 15385160
Alx4 and Msx2 play phenotypically similar and additive roles in skull vault differentiation.
Antonopoulou I, Mavrogiannis LA, Wilkie AO, Morriss-Kay GM
J Anat. 2004
PubMed ID: 15198690
Twist is required for patterning the cranial nerves and maintaining the viability of mesodermal cells.
Ota MS, Loebel DA, O'Rourke MP, Wong N, Tsoi B, Tam PP
Dev Dyn. 2004
PubMed ID: 15162501
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog ( Shh).
Sagai T, Masuya H, Tamura M, Shimizu K, Yada Y, Wakana S, Gondo Y, Noda T, Shiroishi T
Mamm Genome. 2004
PubMed ID: 14727139
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4.
Rice R, Rice DP, Olsen BR, Thesleff I
Dev Biol. 2003
PubMed ID: 14512019
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
The Fused toes (Ft) mouse mutation causes anteroposterior and dorsoventral polydactyly.
Grotewold L, Rüther U
Dev Biol. 2002
PubMed ID: 12413903
Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb.
Liu Y, Liu C, Yamada Y, Fan CM
Development. 2002
PubMed ID: 12399319
Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.
te Welscher P, Zuniga A, Kuijper S, Drenth T, Goedemans HJ, Meijlink F, Zeller R
Science. 2002
PubMed ID: 12215652
Specification of jaw subdivisions by Dlx genes.
Depew MJ, Lufkin T, Rubenstein JL
Science. 2002
PubMed ID: 12193642
Genetic modifiers of otocephalic phenotypes in Otx2 heterozygous mutant mice.
Hide T, Hatakeyama J, Kimura-Yoshida C, Tian E, Takeda N, Ushio Y, Shiroishi T, Aizawa S, Matsuo I
Development. 2002
PubMed ID: 12183386
Functions of FGF signalling from the apical ectodermal ridge in limb development.
Sun X, Mariani FV, Martin GR
Nature. 2002
PubMed ID: 12152071
Twist plays an essential role in FGF and SHH signal transduction during mouse limb development.
O'Rourke MP, Soo K, Behringer RR, Hui CC, Tam PP
Dev Biol. 2002
PubMed ID: 12142027
Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo.
Soo K, O'Rourke MP, Khoo PL, Steiner KA, Wong N, Behringer RR, Tam PP
Dev Biol. 2002
PubMed ID: 12086465
Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds.
Loebel DA, O'Rourke MP, Steiner KA, Banyer J, Tam PP
Genesis. 2002
PubMed ID: 12124942
Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling.
te Welscher P, Fernandez-Teran M, Ros MA, Zeller R
Genes Dev. 2002
PubMed ID: 11850405
Alx4 binding to LEF-1 regulates N-CAM promoter activity.
Boras K, Hamel PA
J Biol Chem. 2002
PubMed ID: 11696550
The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud.
Yada Y, Makino S, Chigusa-Ishiwa S, Shiroishi T
Int J Dev Biol. 2002
PubMed ID: 12455637
Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice.
Beverdam A, Brouwer A, Reijnen M, Korving J, Meijlink F
Development. 2001
PubMed ID: 11641221
Expression patterns of group-I aristaless-related genes during craniofacial and limb development.
Beverdam A, Meijlink F
Mech Dev. 2001
PubMed ID: 11520673
Hoxb2 and hoxb4 act together to specify ventral body wall formation.
Manley NR, Barrow JR, Zhang T, Capecchi MR
Dev Biol. 2001
PubMed ID: 11518511
Genetic loci influencing natural variations in femoral bone morphometry in mice.
Drake TA, Hannani K, Kabo JM, Villa V, Krass K, Lusis AJ
J Orthop Res. 2001
PubMed ID: 11518254
Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O
DNA Res. 2001
PubMed ID: 11347906
Haploinsufficiency of the human homeobox gene ALX4 causes skull ossification defects.
Mavrogiannis LA, Antonopoulou I, Baxová A, Kutílek S, Kim CA, Sugayama SM, Salamanca A, Wall SA, Morriss-Kay GM, Wilkie AO
Nat Genet. 2001
PubMed ID: 11137991
The ALX4 homeobox gene is mutated in patients with ossification defects of the skull (foramina parietalia permagna, OMIM 168500).
Wuyts W, Cleiren E, Homfray T, Rasore-Quartino A, Vanhoenacker F, Van Hul W
J Med Genet. 2000
PubMed ID: 11106354
Haploinsufficiency of ALX4 as a potential cause of parietal foramina in the 11p11.2 contiguous gene-deletion syndrome.
Wu YQ, Badano JL, McCaskill C, Vogel H, Potocki L, Shaffer LG
Am J Hum Genet. 2000
PubMed ID: 11017806
Suppression of polydactyly of the Gli3 mutant (extra toes) by deltaEF1 homozygous mutation.
Moribe H, Takagi T, Kondoh H, Higashi Y
Dev Growth Differ. 2000
PubMed ID: 10969736
Targeted misexpression of constitutively active BMP receptor-IB causes bifurcation, duplication, and posterior transformation of digit in mouse limb.
Zhang Z, Yu X, Zhang Y, Geronimo B, Lovlie A, Fromm SH, Chen Y
Dev Biol. 2000
PubMed ID: 10753507
Genetic profile of insertion mutations in mouse leukemias and lymphomas.
Hansen GM, Skapura D, Justice MJ
Genome Res. 2000
PubMed ID: 10673281
The dominant hemimelia mutation uncouples epithelial-mesenchymal interactions and disrupts anterior mesenchyme formation in mouse hindlimbs.
Lettice L, Hecksher-Sørensen J, Hill RE
Development. 1999
PubMed ID: 10518490
Physical and genetic interactions between Alx4 and Cart1.
Qu S, Tucker SC, Zhao Q, deCrombrugghe B, Wisdom R
Development. 1999
PubMed ID: 9847249
Vertebrate aristaless-related genes.
Meijlink F, Beverdam A, Brouwer A, Oosterveen TC, Berge DT
Int J Dev Biol. 1999
PubMed ID: 10668975
The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development.
Takahashi M, Tamura K, Büscher D, Masuya H, Yonei-Tamura S, Matsumoto K, Naitoh-Matsuo M, Takeuchi J, Ogura K, Shiroishi T, Ogura T, Belmonte JC
Development. 1998
PubMed ID: 9778501
Alx-4, a transcriptional activator whose expression is restricted to sites of epithelial-mesenchymal interactions.
Hudson R, Taniguchi-Sidle A, Boras K, Wiggan O, Hamel PA
Dev Dyn. 1998
PubMed ID: 9786416
Mutations in mouse Aristaless-like4 cause Strong's luxoid polydactyly.
Qu S, Tucker SC, Ehrlich JS, Levorse JM, Flaherty LA, Wisdom R, Vogt TF
Development. 1998
PubMed ID: 9636085
Evaluation of mouse Sfrp3/Frzb1 as a candidate for the lst, Ul, and Far mutants on chromosome 2.
Peichel CL, Kozak CA, Luyten FP, Vogt TF
Mamm Genome. 1998
PubMed ID: 9545497
Alx-4: cDNA cloning and characterization of a novel paired-type homeodomain protein.
Qu S, Li L, Wisdom R
Gene. 1997
PubMed ID: 9426253
Polydactyly and ectopic ZPA formation in Alx-4 mutant mice.
Qu S, Niswender KD, Ji Q, van der Meer R, Keeney D, Magnuson MA, Wisdom R
Development. 1997
PubMed ID: 9374397
Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4.
Dunn NR, Winnier GE, Hargett LK, Schrick JJ, Fogo AB, Hogan BL
Dev Biol. 1997
PubMed ID: 9268572
Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo.
Dunwoodie SL, Henrique D, Harrison SM, Beddington RS
Development. 1997
PubMed ID: 9272948
Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice.
Platt KA, Michaud J, Joyner AL
Mech Dev. 1997
PubMed ID: 9152005
Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse.
Masuya H, Sagai T, Moriwaki K, Shiroishi T
Dev Biol. 1997
PubMed ID: 9073443
Delineation of a contiguous gene syndrome with multiple exostoses, enlarged parietal foramina, craniofacial dysostosis, and mental retardation, caused by deletions in the short arm of chromosome 11.
Bartsch O, Wuyts W, Van Hul W, Hecht JT, Meinecke P, Hogue D, Werner W, Zabel B, Hinkel GK, Powell CM, Shaffer LG, Willems PJ
Am J Hum Genet. 1996
PubMed ID: 8644736
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
Goodrich LV, Johnson RL, Milenkovic L, McMahon JA, Scott MP
Genes Dev. 1996
PubMed ID: 8595881
Polydactyly in the Strong's luxoid mouse is suppressed by limb deformity alleles.
Vogt TF, Leder P
Dev Genet. 1996
PubMed ID: 8792607
WAGR syndrome and multiple exostoses in a patient with del(11)(p11.2p14.2).
McGaughran JM, Ward HB, Evans DG
J Med Genet. 1995
PubMed ID: 8558565
Polydactylous limbs in Strong's Luxoid mice result from ectopic polarizing activity.
Chan DC, Laufer E, Tabin C, Leder P
Development. 1995
PubMed ID: 7635045
Deficient outgrowth of the ureteric bud underlies the renal agenesis phenotype in mice manifesting the limb deformity (ld) mutation.
Maas R, Elfering S, Glaser T, Jepeal L
Dev Dyn. 1994
PubMed ID: 7517224
The interfrontal bone and mutant genes in the mouse.
Johnson DR
J Anat. 1976
PubMed ID: 1018005
The effects of 5-fluorouracil and 5-fluorodeoxyuridine used alone and in combination with normal nucleic acid precursors on development of mice in lines selected for low and high expression of Strong's luxoid gene.
Forsthoefel PF, Williams ML
Teratology. 1975
PubMed ID: 124471
Linkage relationships of Strong's luxoid gene in the mouse.
Forsthoefel PF, Shenk TE
J Hered. 1970
PubMed ID: 5480943
Responses to selection for plus and minus modifiers of some effects of Strong's luxoid gene on the mouse skeleton.
Forsthoefel PF
Teratology. 1968
PubMed ID: 5759552
THE EMBRYOLOGICAL DEVELOPMENT OF THE EFFECTS OF STRONG'S LUXOID GENE IN THE MOUSE.
FORSTHOEFEL PF
J Morphol. 1963
PubMed ID: 14079603
Genetics and manifold effects of Strong's luxoid gene in the mouse, including its interactions with Green's luxoid and Carter's luxate genes.
FORSTHOEFEL PF
J Morphol. 1962
PubMed ID: 13894155
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	Human	Mouse	Rat
Entrez Gene	60529	11695	296511
EnsEMBL Gene(s)	ENSG00000052850	ENSMUSG00000040310	ENSRNOG00000000008
Unigene	Hs.436055	Mm.389389	Rn.218669
Homologene	ALX4	Alx4	Alx4
OMIM	605420	N/A	N/A
GeneCards	ALX4	N/A	N/A
Beta Cell Genomics	DT.100742378 DT.91966405	DT.87063642 DT.91446563	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	60529	11695	296511

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