RGS2

Summary Top Help

Gene Description:

regulator of G-protein signaling 2, 24kDa; regulator of G-protein signaling 2

Synonyms:

RGS2, G0S8, GOS8, Rgs2

Orthologs:

Human RGS2 (protein-coding), Mouse Rgs2 (protein-coding), Rat Rgs2 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 2

Linkage Regions: 2 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd5.4	Mouse	chr1:77143053..147306684	70.16	502
Idd5.4a	Mouse	chr1:77143053..147306684	70.16	454

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr1:192778169..192781407 (3.24 kb) View in Genome Browser

(Mouse) NCBIM37 - chr1:145846468..145851291 (4.82 kb) View in Genome Browser

(Rat) RGSC3.4 - chr13:57890949..57894465 (3.52 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for RGS2:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for RGS2:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 24

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 169

A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
Resistance to age-related, normal body weight gain in RGS2 deficient mice.
Nunn C, Zhao P, Zou MX, Summers K, Guglielmo CG, Chidiac P
Cell Signal. 2011
PubMed ID: 21447383
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population.
Kamide K, Kokubo Y, Yang J, Takiuchi S, Horio T, Matsumoto S, Banno M, Matayoshi T, Yasuda H, Miwa Y, Yoshihara F, Nakamura S, Nakahama H, Iwashima Y, Oguro R, Ohishi M, Rakugi H, Okamura T, Miyata T, Kawano Y
Hypertens Res. 2011
PubMed ID: 21451528
Association of RGS2 variants with panic disorder in a Japanese population.
Otowa T, Shimada T, Kawamura Y, Sugaya N, Yoshida E, Inoue K, Yasuda S, Liu X, Minato T, Tochigi M, Umekage T, Kasai K, Tanii H, Okazaki Y, Kaiya H, Sasaki T
Am J Med Genet B Neuropsychiatr Genet. 2011
PubMed ID: 21438143
Potent and selective inhibition of angiotensin AT1 receptor signaling by RGS2: roles of its N-terminal domain.
Matsuzaki N, Nishiyama M, Song D, Moroi K, Kimura S
Cell Signal. 2011
PubMed ID: 21291998
RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling.
Chakir K, Zhu W, Tsang S, Woo AY, Yang D, Wang X, Zeng X, Rhee MH, Mende U, Koitabashi N, Takimoto E, Blumer KJ, Lakatta EG, Kass DA, Xiao RP
J Mol Cell Cardiol. 2011
PubMed ID: 21291891
Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells.
Salim S, Asghar M, Taneja M, Hovatta I, Wu YL, Saha K, Sarraj N, Hite B
FEBS Lett. 2011
PubMed ID: 21510939
Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation.
Seredenina T, Gokce O, Luthi-Carter R
PLoS One. 2011
PubMed ID: 21779398
Rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of MCP-1.
Boelte KC, Gordy LE, Joyce S, Thompson MA, Yang L, Lin PC
PLoS One. 2011
PubMed ID: 21494556
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Analysis of RGS2 expression and prognostic significance in stage II and III colorectal cancer.
Jiang Z, Wang Z, Xu Y, Wang B, Huang W, Cai S
Biosci Rep. 2010
PubMed ID: 20001967
Family-Based Analysis of Genetic Variation Underlying Psychosis-Inducing Effects of Cannabis: Sibling Analysis and Proband Follow-up.
van Winkel R, Genetic Risk and Outcome of Psychosis (GROUP) Investigators
Arch Gen Psychiatry. 2010
PubMed ID: 21041608
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
Wang J, Lippman SM, Lee JJ, Yang H, Khuri FR, Kim E, Lin J, Chang DW, Lotan R, Hong WK, Wu X
Carcinogenesis. 2010
PubMed ID: 20627871
Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2.
Klaiber M, Kruse M, Völker K, Schröter J, Feil R, Freichel M, Gerling A, Feil S, Dietrich A, Londoño JE, Baba HA, Abramowitz J, Birnbaumer L, Penninger JM, Pongs O, Kuhn M
Basic Res Cardiol. 2010
PubMed ID: 20352235
Functional interaction of regulator of G protein signaling-2 with melanin-concentrating hormone receptor 1.
Miyamoto-Matsubara M, Chung S, Saito Y
Ann N Y Acad Sci. 2010
PubMed ID: 20633139
Association study of 182 candidate genes in anorexia nervosa.
Pinheiro AP, Bulik CM, Thornton LM, Sullivan PF, Root TL, Bloss CS, Berrettini WH, Schork NJ, Kaye WH, Bergen AW, Magistretti P, Brandt H, Crawford S, Crow S, Fichter MM, Goldman D, Halmi KA, Johnson C, Kaplan AS, Keel PK, Klump KL, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB
Am J Med Genet B Neuropsychiatr Genet. 2010
PubMed ID: 20468064
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
Platelet Gs hypofunction and abnormal morphology resulting from a heterozygous RGS2 mutation.
Noé L, Di Michele M, Giets E, Thys C, Wittevrongel C, De Vos R, Overbergh L, Waelkens E, Jaeken J, Van Geet C, Freson K
J Thromb Haemost. 2010
PubMed ID: 20403096
RGS2 expression and aldosterone: renin ratio modulate response to drug therapy in hypertensive patients.
Semplicini A, Strapazzon G, Papparella I, Sartori M, Realdi A, Macchini L, Calò LA, Ceolotto G
J Hypertens. 2010
PubMed ID: 20375904
Ischemia induces regulator of G protein signaling 2 (RGS2) protein upregulation and enhances apoptosis in astrocytes.
Endale M, Kim SD, Lee WM, Kim S, Suk K, Cho JY, Park HJ, Wagley Y, Kim S, Oh JW, Rhee MH
Am J Physiol Cell Physiol. 2010
PubMed ID: 20032508
[Association between the regulator of G-protein signaling 2 gene 1891-1892del TC polymorphism with hypertension in Xinjiang Kazakh population]
Zhang J, Li N, Yan Z, Guo Y, Zhou L, Wang H, Yang J, Luo W, Chang J
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010
PubMed ID: 20140863
Evidence for enhanced M3 muscarinic receptor function and sensitivity to atrial arrhythmia in the RGS2-deficient mouse.
Tuomi JM, Chidiac P, Jones DL
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 19966055
Genomic assessment of follicular marker genes as pregnancy predictors for human IVF.
Hamel M, Dufort I, Robert C, Léveillé MC, Leader A, Sirard MA
Mol Hum Reprod. 2010
PubMed ID: 19778949
Association analysis between functional polymorphism of the rs4606 SNP in the RGS2 gene and antipsychotic-induced Parkinsonism in Japanese patients with schizophrenia: results from the Juntendo University Schizophrenia Projects (JUSP).
Higa M, Ohnuma T, Maeshima H, Hatano T, Hanzawa R, Shibata N, Sakai Y, Suzuki T, Arai H
Neurosci Lett. 2010
PubMed ID: 19931593
Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development.
Al-Shami A, Jhaver KG, Vogel P, Wilkins C, Humphries J, Davis JJ, Xu N, Potter DG, Gerhardt B, Mullinax R, Shirley CR, Anderson SJ, Oravecz T
PLoS One. 2010
PubMed ID: 21048919
Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study.
Sugimoto K, Katsuya T, Kamide K, Fujisawa T, Shimaoka I, Ohishi M, Morishita R, Ogihara T, Rakugi H
Int J Hypertens. 2010
PubMed ID: 20981351
Association study of RGS2 gene polymorphisms with panic disorder in Japanese.
Mouri K, Hishimoto A, Fukutake M, Nishiguchi N, Shirakawa O, Maeda K
Kobe J Med Sci. 2010
PubMed ID: 20847599
Association of genetic variations of regulator of G-protein signaling 2 with hypertension in the general Xinjiang Kazakh population.
Li NF, Zhang JH, Yang J, Zhou L, Luo WL, Guo YY, Yao XG, Wang HM, Chang JH
Clin Exp Hypertens. 2010
PubMed ID: 20662725
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer)
PLoS Genet. 2010
PubMed ID: 20628624
Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF
Circulation. 2009
PubMed ID: 19948975
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.
McCauley JL, Zuvich RL, Bradford Y, Kenealy SJ, Schnetz-Boutaud N, Gregory SG, Hauser SL, Oksenberg JR, Mortlock DP, Pericak-Vance MA, Haines JL
Genes Immun. 2009
PubMed ID: 19626040
Translational control by RGS2.
Nguyen CH, Ming H, Zhao P, Hugendubler L, Gros R, Kimball SR, Chidiac P
J Cell Biol. 2009
PubMed ID: 19736320
Hippocampal long-term potentiation is enhanced in urethane-anesthetized RGS2 knockout mice.
Hutchison RM, Chidiac P, Leung LS
Hippocampus. 2009
PubMed ID: 19294649
Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).
Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP
J Biol Chem. 2009
PubMed ID: 19478087
Genetic insight into syncopal tilted population with severe clinical presentation.
Lelonek M, Pietrucha T, Matyjaszczyk M, Goch JH
Auton Neurosci. 2009
PubMed ID: 19243996
Polymorphism C1114G of gene encoding the cardiac regulator of G-protein signaling 2 may be associated with number of episodes of neurally mediated syncope.
Lelonek M, Pietrucha T, Matyjaszczyk M, Goch JH
Arch Med Res. 2009
PubMed ID: 19427970
Variant in RGS2 moderates posttraumatic stress symptoms following potentially traumatic event exposure.
Amstadter AB, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J
J Anxiety Disord. 2009
PubMed ID: 19162436
Sphingosine-1-phosphate regulates RGS2 and RGS16 mRNA expression in vascular smooth muscle cells.
Hendriks-Balk MC, Hajji N, van Loenen PB, Michel MC, Peters SL, Alewijnse AE
Eur J Pharmacol. 2009
PubMed ID: 19374869
Lack of association between antipsychotic-induced Parkinsonism or its subsymptoms and rs4606 SNP of RGS2 gene in African-Caribbeans and the possible role of the medication: the Curacao extrapyramidal syndromes study X.
Al Hadithy AF, Wilffert B, Bruggeman R, Stewart RE, Brouwers JR, Matroos GE, Hoek HW, van Harten PN
Hum Psychopharmacol. 2009
PubMed ID: 19156702
Evidence for a direct and functional interaction between the regulators of G protein signaling-2 and phosphorylated C terminus of cholecystokinin-2 receptor.
Langer I, Tikhonova IG, Boulègue C, Estève JP, Vatinel S, Ferrand A, Moroder L, Robberecht P, Fourmy D
Mol Pharmacol. 2009
PubMed ID: 19064631
The environmental and genetic evidence for the association of hyperlipidemia and hypertension.
Ruixing Y, Jinzhen W, Weixiong L, Yuming C, Dezhai Y, Shangling P
J Hypertens. 2009
PubMed ID: 19155782
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.
Takimoto E, Koitabashi N, Hsu S, Ketner EA, Zhang M, Nagayama T, Bedja D, Gabrielson KL, Blanton R, Siderovski DP, Mendelsohn ME, Kass DA
J Clin Invest. 2009
PubMed ID: 19127022
Variation in RGS2 is associated with suicidal ideation in an epidemiological study of adults exposed to the 2004 Florida hurricanes.
Amstadter AB, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J
Arch Suicide Res. 2009
PubMed ID: 19813112
RGS2-deficient mice exhibit decreased intraocular pressure and increased retinal ganglion cell survival.
Inoue-Mochita M, Inoue T, Epstein DL, Blumer KJ, Rao PV
Mol Vis. 2009
PubMed ID: 19262744
Are RGS2 gene polymorphisms associated with high blood pressure in an ethnicity- and gender-specific manner?
Hahntow IN, Mairuhu G, van Valkengoed IG, Baas F, Alewijnse AE, Koopmans RP, Michel MC
Am J Hypertens. 2009
PubMed ID: 19023274
Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction.
Mederos y Schnitzler M, Storch U, Meibers S, Nurwakagari P, Breit A, Essin K, Gollasch M, Gudermann T
EMBO J. 2008
PubMed ID: 18987636
An abnormal gene expression of the beta-adrenergic system contributes to the pathogenesis of cardiomyopathy in cirrhotic rats.
Ceolotto G, Papparella I, Sticca A, Bova S, Cavalli M, Cargnelli G, Semplicini A, Gatta A, Angeli P
Hepatology. 2008
PubMed ID: 19003918
Regulation of LH receptor and PGF2alpha receptor signaling by the regulator of G protein signaling 2 (RGS2) in human and mouse granulosa cells.
Wu YL, Chuang HH, Kou YR, Lee TS, Lu SH, Huang YC, Nishi Y, Yanase T
Chin J Physiol. 2008
PubMed ID: 19175184
Characterization of the transcriptional regulation of the regulator of G protein signaling 2 (RGS2) gene during 3T3-L1 preadipocyte differentiation.
Cheng YS, Lee TS, Hsu HC, Kou YR, Wu YL
J Cell Biochem. 2008
PubMed ID: 18726905
Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors.
Teplyuk NM, Galindo M, Teplyuk VI, Pratap J, Young DW, Lapointe D, Javed A, Stein JL, Lian JB, Stein GS, van Wijnen AJ
J Biol Chem. 2008
PubMed ID: 18625716
RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults.
Koenen KC, Amstadter AB, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J
Depress Anxiety. 2008
PubMed ID: 18833580
Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR).
Strug LJ, Suresh R, Fyer AJ, Talati A, Adams PB, Li W, Hodge SE, Gilliam TC, Weissman MM
Mol Psychiatry. 2008
PubMed ID: 18663369
Wdnm1-like, a new adipokine with a role in MMP-2 activation.
Wu Y, Smas CM
Am J Physiol Endocrinol Metab. 2008
PubMed ID: 18492766
Interactions among genetic variants from contractile pathway of vascular smooth muscle cell in essential hypertension susceptibility of Chinese Han population.
Zhao Q, Wang L, Yang W, Chen S, Huang J, Fan Z, Li H, Lu X, Gu D
Pharmacogenet Genomics. 2008
PubMed ID: 18496125
Association of RGS2 Gene Polymorphisms with Suicide and Increased RGS2 Immunoreactivity in the Postmortem Brain of Suicide Victims.
Cui H, Nishiguchi N, Ivleva E, Yanagi M, Fukutake M, Nushida H, Ueno Y, Kitamura N, Maeda K, Shirakawa O
Neuropsychopharmacology. 2008
PubMed ID: 17728697
Silencing regulator of G protein signaling-2 (RGS-2) increases angiotensin II signaling: insights into hypertension from findings in Bartter's/Gitelman's syndromes.
Calò LA, Pagnin E, Ceolotto G, Davis PA, Schiavo S, Papparella I, Semplicini A, Pessina AC
J Hypertens. 2008
PubMed ID: 18398336
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18434541
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Association of RGS2 and RGS5 variants with schizophrenia symptom severity.
Campbell DB, Lange LA, Skelly T, Lieberman J, Levitt P, Sullivan PF
Schizophr Res. 2008
PubMed ID: 18262772
The RGS2 gene product from a candidate hypertension allele shows decreased plasma membrane association and inhibition of Gq.
Gu S, Tirgari S, Heximer SP
Mol Pharmacol. 2008
PubMed ID: 18230714
Further evidence for association of the RGS2 gene with antipsychotic-induced parkinsonism: protective role of a functional polymorphism in the 3'-untranslated region.
Greenbaum L, Smith RC, Rigbi A, Strous R, Teltsh O, Kanyas K, Korner M, Lancet D, Ben-Asher E, Lerer B
Pharmacogenomics J. 2008
PubMed ID: 18347610
Influence of RGS2 on anxiety-related temperament, personality, and brain function.
Smoller JW, Paulus MP, Fagerness JA, Purcell S, Yamaki LH, Hirshfeld-Becker D, Biederman J, Rosenbaum JF, Gelernter J, Stein MB
Arch Gen Psychiatry. 2008
PubMed ID: 18316676
RGS2 C1114G polymorphism and body weight gain in hypertensive patients.
Sartori M, Ceolotto G, Dorigatti F, Mos L, Santonastaso M, Bratti P, Papparella I, Semplicini A, Palatini P, HARVEST Group
Metabolism. 2008
PubMed ID: 18249218
RGS5, RGS4, and RGS2 expression and aortic contractibility are dynamically co-regulated during aortic banding-induced hypertrophy.
Wang X, Adams LD, Pabón LM, Mahoney WM, Beaudry D, Gunaje J, Geary RL, Deblois D, Schwartz SM
J Mol Cell Cardiol. 2008
PubMed ID: 18207159
Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension.
Kohara K, Tabara Y, Nakura J, Imai Y, Ohkubo T, Hata A, Soma M, Nakayama T, Umemura S, Hirawa N, Ueshima H, Kita Y, Ogihara T, Katsuya T, Takahashi N, Tokunaga K, Miki T
Hypertens Res. 2008
PubMed ID: 18360038
Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins.
Gu S, Anton A, Salim S, Blumer KJ, Dessauer CW, Heximer SP
Mol Pharmacol. 2008
PubMed ID: 17901199
RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area.
Labouèbe G, Lomazzi M, Cruz HG, Creton C, Luján R, Li M, Yanagawa Y, Obata K, Watanabe M, Wickman K, Boyer SB, Slesinger PA, Lüscher C
Nat Neurosci. 2007
PubMed ID: 17965710
Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice.
Hercule HC, Tank J, Plehm R, Wellner M, da Costa Goncalves AC, Gollasch M, Diedrich A, Jordan J, Luft FC, Gross V
Exp Physiol. 2007
PubMed ID: 17644703
Role of regulator of G-protein signaling 2 (RGS2) in periodontal ligament cells under mechanical stress.
Santos de Araujo RM, Oba Y, Moriyama K
Cell Biochem Funct. 2007
PubMed ID: 17294519
Sympathetic nerve traffic and circulating norepinephrine levels in RGS2-deficient mice.
Tank J, Obst M, Diedrich A, Brychta RJ, Blumer KJ, Heusser K, Jordan J, Luft FC, Gross V
Auton Neurosci. 2007
PubMed ID: 17507294
Regulation of RGS2 and second messenger signaling in vascular smooth muscle cells by cGMP-dependent protein kinase.
Osei-Owusu P, Sun X, Drenan RM, Steinberg TH, Blumer KJ
J Biol Chem. 2007
PubMed ID: 17681944
Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells.
Xie Z, Gong MC, Su W, Turk J, Guo Z
J Biol Chem. 2007
PubMed ID: 17613534
Association of the RGS2 gene with extrapyramidal symptoms induced by treatment with antipsychotic medication.
Greenbaum L, Strous RD, Kanyas K, Merbl Y, Horowitz A, Karni O, Katz E, Kotler M, Olender T, Deshpande SN, Lancet D, Ben-Asher E, Lerer B
Pharmacogenet Genomics. 2007
PubMed ID: 17558307
Increased renal responsiveness to vasopressin and enhanced V2 receptor signaling in RGS2-/- mice.
Zuber AM, Singer D, Penninger JM, Rossier BC, Firsov D
J Am Soc Nephrol. 2007
PubMed ID: 17475820
N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells.
Bodenstein J, Sunahara RK, Neubig RR
Mol Pharmacol. 2007
PubMed ID: 17220356
RGS proteins: Swiss army knives in seven-transmembrane domain receptor signaling networks.
Heximer SP, Blumer KJ
Sci STKE. 2007
PubMed ID: 17244887
Regulator of G-protein signalling 2 mRNA is differentially expressed in mammary epithelial subpopulations and over-expressed in the majority of breast cancers.
Smalley MJ, Iravani M, Leao M, Grigoriadis A, Kendrick H, Dexter T, Fenwick K, Regan JL, Britt K, McDonald S, Lord CJ, Mackay A, Ashworth A
Breast Cancer Res. 2007
PubMed ID: 18067675
Vascular microarray profiling in two models of hypertension identifies caveolin-1, Rgs2 and Rgs5 as antihypertensive targets.
Grayson TH, Ohms SJ, Brackenbury TD, Meaney KR, Peng K, Pittelkow YE, Wilson SR, Sandow SL, Hill CE
BMC Genomics. 2007
PubMed ID: 17986358
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
-391 C to G substitution in the regulator of G-protein signalling-2 promoter increases susceptibility to the metabolic syndrome in white European men: consistency between molecular and epidemiological studies.
Freson K, Stolarz K, Aerts R, Brand E, Brand-Herrmann SM, Kawecka-Jaszcz K, Kuznetsova T, Tikhonoff V, Thijs L, Vermylen J, Staessen JA, Van Geet C, European Project on Genes in Hypertension Investigators
J Hypertens. 2007
PubMed ID: 17143182
Rgs 2 gene polymorphisms as modulators of anxiety in humans?
Leygraf A, Hohoff C, Freitag C, Willis-Owen SA, Krakowitzky P, Fritze J, Franke P, Bandelow B, Fimmers R, Flint J, Deckert J
J Neural Transm. 2006
PubMed ID: 16736243
Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts.
Roy AA, Nunn C, Ming H, Zou MX, Penninger J, Kirshenbaum LA, Dixon SJ, Chidiac P
J Biol Chem. 2006
PubMed ID: 16950788
RGS2 inhibits the epithelial Ca2+ channel TRPV6.
Schoeber JP, Topala CN, Wang X, Diepens RJ, Lambers TT, Hoenderop JG, Bindels RJ
J Biol Chem. 2006
PubMed ID: 16895908
RGS2 is upregulated by and attenuates the hypertrophic effect of alpha1-adrenergic activation in cultured ventricular myocytes.
Zou MX, Roy AA, Zhao Q, Kirshenbaum LA, Karmazyn M, Chidiac P
Cell Signal. 2006
PubMed ID: 16517124
RGS2 determines short-term synaptic plasticity in hippocampal neurons by regulating Gi/o-mediated inhibition of presynaptic Ca2+ channels.
Han J, Mark MD, Li X, Xie M, Waka S, Rettig J, Herlitze S
Neuron. 2006
PubMed ID: 16950156
RGS2 is regulated by angiotensin II and functions as a negative feedback of aldosterone production in H295R human adrenocortical cells.
Romero DG, Plonczynski MW, Gomez-Sanchez EP, Yanes LL, Gomez-Sanchez CE
Endocrinology. 2006
PubMed ID: 16627589
Regulator of G-protein signaling 2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cells.
Cao X, Qin J, Xie Y, Khan O, Dowd F, Scofield M, Lin MF, Tu Y
Oncogene. 2006
PubMed ID: 16449965
A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans.
Gu J, Wu X, Dong Q, Romeo MJ, Lin X, Gutkind JS, Berman DM
Cancer. 2006
PubMed ID: 16691626
Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II.
Semplicini A, Lenzini L, Sartori M, Papparella I, Calò LA, Pagnin E, Strapazzon G, Benna C, Costa R, Avogaro A, Ceolotto G, Pessina AC
J Hypertens. 2006
PubMed ID: 16685212
The DNA sequence and biological annotation of human chromosome 1.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E
Nature. 2006
PubMed ID: 16710414
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
NO-dependent blood pressure regulation in RGS2-deficient mice.
Obst M, Tank J, Plehm R, Blumer KJ, Diedrich A, Jordan J, Luft FC, Gross V
Am J Physiol Regul Integr Comp Physiol. 2006
PubMed ID: 16269576
Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy.
Zhang W, Anger T, Su J, Hao J, Xu X, Zhu M, Gach A, Cui L, Liao R, Mende U
J Biol Chem. 2006
PubMed ID: 16380388
Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives.
Riddle EL, Rana BK, Murthy KK, Rao F, Eskin E, O'Connor DT, Insel PA
Hypertension. 2006
PubMed ID: 16432041
Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy.
James CG, Appleton CT, Ulici V, Underhill TM, Beier F
Mol Biol Cell. 2005
PubMed ID: 16135533
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
Using progenitor strain information to identify quantitative trait nucleotides in outbred mice.
Yalcin B, Flint J, Mott R
Genetics. 2005
PubMed ID: 16085706
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population.
Yang J, Kamide K, Kokubo Y, Takiuchi S, Tanaka C, Banno M, Miwa Y, Yoshii M, Horio T, Okayama A, Tomoike H, Kawano Y, Miyata T
J Hypertens. 2005
PubMed ID: 16003176
Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop.
Hague C, Bernstein LS, Ramineni S, Chen Z, Minneman KP, Hepler JR
J Biol Chem. 2005
PubMed ID: 15917235
Autonomic nervous system and blood pressure regulation in RGS2-deficient mice.
Gross V, Tank J, Obst M, Plehm R, Blumer KJ, Diedrich A, Jordan J, Luft FC
Am J Physiol Regul Integr Comp Physiol. 2005
PubMed ID: 15661972
Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis.
Beckers J, Herrmann F, Rieger S, Drobyshev AL, Horsch M, Hrabé de Angelis M, Seliger B
Int J Cancer. 2005
PubMed ID: 15609325
Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors.
Wang X, Zeng W, Soyombo AA, Tang W, Ross EM, Barnes AP, Milgram SL, Penninger JM, Allen PB, Greengard P, Muallem S
Nat Cell Biol. 2005
PubMed ID: 15793568
RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling.
Sun X, Kaltenbronn KM, Steinberg TH, Blumer KJ
Mol Pharmacol. 2005
PubMed ID: 15563583
RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation.
Schwäble J, Choudhary C, Thiede C, Tickenbrock L, Sargin B, Steur C, Rehage M, Rudat A, Brandts C, Berdel WE, Müller-Tidow C, Serve H
Blood. 2005
PubMed ID: 15536149
Developmentally regulated expression of the regulator of G-protein signaling gene 2 (Rgs2) in the embryonic mouse pituitary.
Wilson LD, Ross SA, Lepore DA, Wada T, Penninger JM, Thomas PQ
Gene Expr Patterns. 2005
PubMed ID: 15661635
Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor.
Tovey SC, Willars GB
Mol Pharmacol. 2004
PubMed ID: 15383626
Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice.
Yalcin B, Willis-Owen SA, Fullerton J, Meesaq A, Deacon RM, Rawlins JN, Copley RR, Morris AP, Flint J, Mott R
Nat Genet. 2004
PubMed ID: 15489855
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Role of regulator of G protein signaling 2 (RGS2) in Ca(2+) oscillations and adaptation of Ca(2+) signaling to reduce excitability of RGS2-/- cells.
Wang X, Huang G, Luo X, Penninger JM, Muallem S
J Biol Chem. 2004
PubMed ID: 15292238
A functional polymorphism in RGS6 modulates the risk of bladder cancer.
Berman DM, Wang Y, Liu Z, Dong Q, Burke LA, Liotta LA, Fisher R, Wu X
Cancer Res. 2004
PubMed ID: 15375002
RGS 2 expression is regulated by TSH and inhibits TSH receptor signaling.
Eszlinger M, Holzapfel HP, Voigt C, Arkenau C, Paschke R
Eur J Endocrinol. 2004
PubMed ID: 15362969
A gene-driven ENU-based approach to generating an allelic series in any gene.
Quwailid MM, Hugill A, Dear N, Vizor L, Wells S, Horner E, Fuller S, Weedon J, McMath H, Woodman P, Edwards D, Campbell D, Rodger S, Carey J, Roberts A, Glenister P, Lalanne Z, Parkinson N, Coghill EL, McKeone R, Cox S, Willan J, Greenfield A, Keays D, Brady S, Spurr N, Gray I, Hunter J, Brown SD, Cox RD
Mamm Genome. 2004
PubMed ID: 15457338
Increased expression of regulator of G protein signaling-2 (RGS-2) in Bartter's/Gitelman's syndrome. A role in the control of vascular tone and implication for hypertension.
Calò LA, Pagnin E, Davis PA, Sartori M, Ceolotto G, Pessina AC, Semplicini A
J Clin Endocrinol Metab. 2004
PubMed ID: 15292363
RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling.
Bernstein LS, Ramineni S, Hague C, Cladman W, Chidiac P, Levey AI, Hepler JR
J Biol Chem. 2004
PubMed ID: 14976183
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure.
Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME, Tang M, Wang G
Nat Med. 2003
PubMed ID: 14608379
Identification of differentially expressed genes in mouse spermatogenesis.
Pang AL, Taylor HC, Johnson W, Alexander S, Chen Y, Su YA, Li X, Ravindranath N, Dym M, Rennert OM, Chan WY
J Androl. 2003
PubMed ID: 14581517
Expression of regulator of G-protein signalling protein 2 (RGS2) in the mouse uterus at implantation sites.
Huang ZP, Ni H, Yang ZM, Wang J, Tso JK, Shen QX
Reproduction. 2003
PubMed ID: 12968938
Differential interaction of GRK2 with members of the G alpha q family.
Day PW, Carman CV, Sterne-Marr R, Benovic JL, Wedegaertner PB
Biochemistry. 2003
PubMed ID: 12885252
Vitamin D and dexamethasone inversely regulate parathyroid hormone-induced regulator of G protein signaling-2 expression in osteoblast-like cells.
Hömme M, Schmitt CP, Himmele R, Hoffmann GF, Mehls O, Schaefer F
Endocrinology. 2003
PubMed ID: 12746312
Identification of RGS2 and type V adenylyl cyclase interaction sites.
Salim S, Sinnarajah S, Kehrl JH, Dessauer CW
J Biol Chem. 2003
PubMed ID: 12604604
The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling.
Cho H, Harrison K, Schwartz O, Kehrl JH
Biochem J. 2003
PubMed ID: 12564955
Expression of regulator of G protein signaling-2 in rat myometrium during pregnancy and parturition.
Suarez VR, Park ES, Hankins GD, Soloff MS
Am J Obstet Gynecol. 2003
PubMed ID: 12712095
Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions.
Taymans JM, Leysen JE, Langlois X
J Neurochem. 2003
PubMed ID: 12603835
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.
Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ
J Clin Invest. 2003
PubMed ID: 12588882
RGS2: a "turn-off" in hypertension.
Le TH, Coffman TM
J Clin Invest. 2003
PubMed ID: 12588881
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Regulator of G-protein signaling protein 2 modulates purinergic calcium and ciliary beat frequency responses in airway epithelia.
Nlend MC, Bookman RJ, Conner GE, Salathe M
Am J Respir Cell Mol Biol. 2002
PubMed ID: 12356577
Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure.
Mittmann C, Chung CH, Höppner G, Michalek C, Nose M, Schüler C, Schuh A, Eschenhagen T, Weil J, Pieske B, Hirt S, Wieland T
Cardiovasc Res. 2002
PubMed ID: 12176127
Parathyroid hormone induces RGS-2 expression by a cyclic adenosine 3',5'-monophosphate-mediated pathway in primary neonatal murine osteoblasts.
Tsingotjidou A, Nervina JM, Pham L, Bezouglaia O, Tetradis S
Bone. 2002
PubMed ID: 11996904
Evolution of the regulators of G-protein signaling multigene family in mouse and human.
Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM
Genomics. 2002
PubMed ID: 11829488
Detailed localization of regulator of G protein signaling 2 messenger ribonucleic acid and protein in the rat brain.
Taymans JM, Wintmolders C, Te Riele P, Jurzak M, Groenewegen HJ, Leysen JE, Langlois X
Neuroscience. 2002
PubMed ID: 12207953
Analysis of regulator of G-protein signaling-2 (RGS-2) expression and function in osteoblastic cells.
Thirunavukkarasu K, Halladay DL, Miles RR, Geringer CD, Onyia JE
J Cell Biochem. 2002
PubMed ID: 11968023
Inducible RGS2 is a cross-talk regulator for parathyroid hormone signaling in rat osteoblast-like UMR106 cells.
Ko JK, Choi KH, Kim IS, Jung EK, Park DH
Biochem Biophys Res Commun. 2001
PubMed ID: 11573967
Different regulation of RGS2 mRNA by haloperidol and clozapine.
Robinet EA, Wurch T, Pauwels PJ
Neuroreport. 2001
PubMed ID: 11409749
A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes.
Nagata Y, Oda M, Nakata H, Shozaki Y, Kozasa T, Todokoro K
Blood. 2001
PubMed ID: 11342430
Mechanisms governing subcellular localization and function of human RGS2.
Heximer SP, Lim H, Bernard JL, Blumer KJ
J Biol Chem. 2001
PubMed ID: 11278586
Evidence for a short form of RGS3 preferentially expressed in the human heart.
Mittmann C, Schüler C, Chung CH, Höppner G, Nose M, Kehrl JH, Wieland T
Naunyn Schmiedebergs Arch Pharmacol. 2001
PubMed ID: 11330340
Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.
Cunningham ML, Waldo GL, Hollinger S, Hepler JR, Harden TK
J Biol Chem. 2001
PubMed ID: 11063746
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Regulation of T cell activation, anxiety, and male aggression by RGS2.
Oliveira-Dos-Santos AJ, Matsumoto G, Snow BE, Bai D, Houston FP, Whishaw IQ, Mariathasan S, Sasaki T, Wakeham A, Ohashi PS, Roder JC, Barnes CA, Siderovski DP, Penninger JM
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11027316
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.
Sullivan BM, Harrison-Lavoie KJ, Marshansky V, Lin HY, Kehrl JH, Ausiello DA, Brown D, Druey KM
Mol Biol Cell. 2000
PubMed ID: 10982407
Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs.
Chatterjee TK, Fisher RA
J Biol Chem. 2000
PubMed ID: 10791963
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.
Popov SG, Krishna UM, Falck JR, Wilkie TM
J Biol Chem. 2000
PubMed ID: 10747990
RGS molecule expression in murine B lymphocytes and ability to down-regulate chemotaxis to lymphoid chemokines.
Reif K, Cyster JG
J Immunol. 2000
PubMed ID: 10779778
MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16.
Zheng B, Chen D, Farquhar MG
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10760272
Specific regulation of RGS2 messenger RNA by angiotensin II in cultured vascular smooth muscle cells.
Grant SL, Lassègue B, Griendling KK, Ushio-Fukai M, Lyons PR, Alexander RW
Mol Pharmacol. 2000
PubMed ID: 10692485
Dynamic regulation of RGS2 in bone: potential new insights into parathyroid hormone signaling mechanisms.
Miles RR, Sluka JP, Santerre RF, Hale LV, Bloem L, Boguslawski G, Thirunavukkarasu K, Hock JM, Onyia JE
Endocrinology. 2000
PubMed ID: 10614620
RGS proteins: more than just GAPs for heterotrimeric G proteins.
De Vries L, Gist Farquhar M
Trends Cell Biol. 1999
PubMed ID: 10203790
Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes.
Beadling C, Druey KM, Richter G, Kehrl JH, Smith KA
J Immunol. 1999
PubMed ID: 10072511
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
RGS2/G0S8 is a selective inhibitor of Gqalpha function.
Heximer SP, Watson N, Linder ME, Blumer KJ, Hepler JR
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9405622
Comparison of mRNA expression of two regulators of G-protein signaling, RGS1/BL34/1R20 and RGS2/G0S8, in cultured human blood mononuclear cells.
Heximer SP, Cristillo AD, Forsdyke DR
DNA Cell Biol. 1997
PubMed ID: 9174164
Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast.
Chen C, Zheng B, Han J, Lin SC
J Biol Chem. 1997
PubMed ID: 9079700
Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family.
Druey KM, Blumer KJ, Kang VH, Kehrl JH
Nature. 1996
PubMed ID: 8602223
A new family of regulators of G-protein-coupled receptors?
Siderovski DP, Hessel A, Chung S, Mak TW, Tyers M
Curr Biol. 1996
PubMed ID: 8673468
Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31.
Wu HK, Heng HH, Shi XM, Forsdyke DR, Tsui LC, Mak TW, Minden MD, Siderovski DP
Leukemia. 1995
PubMed ID: 7643615
A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells.
Siderovski DP, Heximer SP, Forsdyke DR
DNA Cell Biol. 1994
PubMed ID: 8179820
A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes.
Siderovski DP, Blum S, Forsdyke RE, Forsdyke DR
DNA Cell Biol. 1990
PubMed ID: 1702972

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	5997	19735	84583
EnsEMBL Gene(s)	ENSG00000116741	ENSMUSG00000026360	ENSRNOG00000003687
Unigene	Hs.78944	Mm.28262	Rn.1892
Homologene	RGS2	Rgs2	Rgs2
OMIM	600861	N/A	N/A
GeneCards	RGS2	N/A	N/A
Beta Cell Genomics	DT.100707690 DT.100808212	DT.494421 DT.94157375	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	5997	19735	84583

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
RGS2	RABAC1	BioGRID	empirical	21900206
RGS2	CHD3	BioGRID	empirical	21900206
RGS2	ADCY5	HPRD, BioGRID	empirical	12604604
RGS2	KLK8	IntAct	empirical	21988832
RGS2	CLTA	IntAct	empirical	21988832
RGS2	COMT	BioGRID	empirical	21900206
RGS2	COPB1	HPRD	empirical	10982407
RGS2	CRMP1	BioGRID	empirical	21900206
RGS2	ADRA1A	HPRD	empirical	15917235
RGS2	CTSB	HPRD, MINT, IntAct, BioGRID	empirical	16169070 21900206
RGS2	ZNF579	BioGRID	empirical	21900206
RGS2	NINL	HPRD, MINT, IntAct, BioGRID	empirical	16189514
RGS2	HAUS5	BioGRID	empirical	21900206
RGS2	TSPAN15	BioGRID	empirical	21900206
RGS2	XRCC6	BioGRID	empirical	21900206
RGS2	IBTK	IntAct, BioGRID	empirical	17353931
RGS2	GNA15	HPRD, BioGRID	empirical	12885252
RGS2	GNAI3	BioGRID	empirical	9079700
RGS2	GNAQ	HPRD, BioGRID	empirical	9405622 12885252
RGS2	GNAS	HPRD, BioGRID	empirical	9794454
RGS2	GIT1	HPRD, MINT, IntAct, BioGRID	empirical	16169070 21900206
RGS2	ZBTB48	BioGRID	empirical	21900206
RGS2	HSPA8	HPRD, MINT, IntAct, BioGRID	empirical	16169070 21900206
RGS2	TUBB2B	BioGRID	empirical	21900206
RGS2	EIF3E	IntAct, BioGRID	empirical	17353931
RGS2	LIG1	BioGRID	empirical	21900206
RGS2	PARK2	HPRD, MINT, IntAct, BioGRID	empirical	16169070 21900206
RGS2	IER3IP1	BioGRID	empirical	21900206
RGS2	EIF3L	BioGRID	empirical	21900206
RGS2	GDE1	HPRD, BioGRID	empirical	10760272
RGS2	VPS29	HPRD, MINT, IntAct, BioGRID	empirical	16169070 21900206
RGS2	WDR74	HPRD, MINT, IntAct, BioGRID	empirical	16169070 21900206
RGS2	PPP1R9A	MINT	empirical	17464283
RGS2	ARFGAP1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
RGS2	PRKCA	HPRD	empirical	11063746
RGS2	PRKCB	HPRD, BioGRID	empirical	11063746
RGS2	PRKCG	HPRD, BioGRID	empirical	11063746
RGS2	PRKCSH	HPRD, MINT, IntAct	empirical	16169070
RGS2	PRKG1	HPRD, BioGRID	empirical	14608379
RGS2	KIAA1377	BioGRID	empirical	21900206
RGS2	LRFN1	IntAct, BioGRID	empirical	16169070 21900206
RGS2	RAB2A	BioGRID	empirical	21900206
RGS2	RAP1B	IntAct	empirical	21988832
RGS2	SCN5A	HPRD, MINT, IntAct	empirical	16169070
RGS2	DUSP21	BioGRID	empirical	21900206
RGS2	UBC	BioGRID	empirical	21900206
RGS2	ZYX	BioGRID	empirical	21900206
RGS2	DDR1	HPRD, MINT, IntAct, BioGRID	empirical	16169070 21900206
RGS2	FZD5	IntAct	empirical	21988832
RGS2	REEP5	BioGRID	empirical	21900206
RGS2	BBS10	BioGRID	empirical	21900206
RGS2	RIN3	BioGRID	empirical	21900206
RGS2	CALM1	HPRD	empirical	10747990
RGS2	MON1A	BioGRID	empirical	21900206
RGS2	PPP1R9B	HPRD, MINT	empirical	17464283
RGS2	NIPSNAP1	HPRD, MINT, IntAct, BioGRID	empirical	16169070 21900206
RGS2	DYNLL1	HPRD, MINT, IntAct	empirical	16169070
RGS2	METTL18	BioGRID	empirical	21900206
RGS2	COPB2	HPRD, BioGRID	empirical	10982407