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PZP

Gene Description:   pregnancy-zone protein; pregnancy zone protein Synonyms:   AI893533, Pzp, A2m, A1m, PZP, MGC133093, CPAMD6, MAM Orthologs:   Human PZP (protein-coding), Mouse Pzp (protein-coding), Rat Pzp (protein-coding)   Sources Sources Human-Mouse: MGD, RGD Human-Rat: MGD, RGD Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Mouse: 1 Rat: 1

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd19	Mouse	chr6:117439553..128469043	11.03	199	2 no lod score

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 12p13.31 Orthologous Region	Rat	chr4:165560615..166552178	0.99	15

(Human) GRCh37 - chr12:9301436..9360966 (59.53 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr6:128433585..128476738 (43.15 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr4:165505085..165579027 (73.94 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for PZP: The PZP interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs PZP   CPB2   HPRD  empirical  8662763  PZP   KLK3   HPRD  empirical  1702714  PZP   KCNMA1   IntAct  empirical  19423573  PZP   MMP2   HPRD, BioGRID  empirical  9344465  PZP   MMP9   HPRD  empirical  9344465  PZP   TGFB1   HPRD  empirical  7513640  PZP   TGFB2   HPRD, BioGRID  empirical  7513640

View all

KEGG Network: None available   None available.

Biocarta: None available   None available.

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 6   Endopeptidase inhibitor activity GO:0004866 Serine-type endopeptidase inhibitor activity GO:0004867 Extracellular region GO:0005576 Extracellular space GO:0005615 Female pregnancy GO:0007565 Negative regulation of endopeptidase activity GO:0010951

	KEGG Network: None available
	Biocarta: None available
	Reactome: None available
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 6 Endopeptidase inhibitor activity GO:0004866 Serine-type endopeptidase inhibitor activity GO:0004867 Extracellular region GO:0005576 Extracellular space GO:0005615 Female pregnancy GO:0007565 Negative regulation of endopeptidase activity GO:0010951

Publications: 63

• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.
  Chalasani N, Guo X, Loomba R, Goodarzi MO, Haritunians T, Kwon S, Cui J, Taylor KD, Wilson L, Cummings OW, Chen YD, Rotter JI, Nonalcoholic Steatohepatitis Clinical Research Network
  Gastroenterology. 2010
  PubMed ID: 20708005
   
  
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
  Mol Med. 2010
  PubMed ID: 20379614
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
  Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H
  J Proteome Res. 2009
  PubMed ID: 19159218
   
  
• An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.
  Edwards TL, Pericak-Vance M, Gilbert JR, Haines JL, Martin ER, Ritchie MD
  Am J Med Genet B Neuropsychiatr Genet. 2008
  PubMed ID: 19105203
   
  
• Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
  Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
  J Proteome Res. 2008
  PubMed ID: 19367708
   
  
• Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor.
  Sánchez C, Sánchez I, Demmers JA, Rodriguez P, Strouboulis J, Vidal M
  Mol Cell Proteomics. 2007
  PubMed ID: 17296600
   
  
• Proteolytic hydrolysis and purification of the LRP/alfa-2-macroglobulin receptor domain from alpha-macroglobulins.
  Barrera DI, Matheus LM, Stigbrand T, Arbeláez LF
  Protein Expr Purif. 2007
  PubMed ID: 17257854
   
  
• Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.
  Bernhard OK, Kapp EA, Simpson RJ
  J Proteome Res. 2007
  PubMed ID: 17330941
   
  
• Large-scale phosphorylation analysis of mouse liver.
  Villén J, Beausoleil SA, Gerber SA, Gygi SP
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17242355
   
  
• The consensus coding sequences of human breast and colorectal cancers.
  Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
  Science. 2006
  PubMed ID: 16959974
   
  
• Proteome-wide characterization of N-glycosylation events by diagonal chromatography.
  Ghesquière B, Van Damme J, Martens L, Vandekerckhove J, Gevaert K
  J Proteome Res. 2006
  PubMed ID: 16944957
   
  
• The finished DNA sequence of human chromosome 12.
  Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA, Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
  Nature. 2006
  PubMed ID: 16541075
   
  
• Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
  Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
  Genome Res. 2006
  PubMed ID: 16344560
   
  
• Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
  Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD
  J Proteome Res. 2005
  PubMed ID: 16335952
   
  
• Characterization of a murine alpha 2 macroglobulin gene expressed in reproductive and cardiovascular tissue.
  He H, McCartney DJ, Wei Q, Esadeg S, Zhang J, Foster RA, Hayes MA, Tayade C, Van Leuven F, Croy BA
  Biol Reprod. 2005
  PubMed ID: 15355875
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• The human plasma proteome: a nonredundant list developed by combination of four separate sources.
  Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A
  Mol Cell Proteomics. 2004
  PubMed ID: 14718574
   
  
• Alpha-2 macroglobulin controls trophoblast positioning in mouse implantation sites.
  Esadeg S, He H, Pijnenborg R, Van Leuven F, Croy BA
  Placenta. 2003
  PubMed ID: 14580373
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
  Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
  Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
  Nature. 2002
  PubMed ID: 12466851
   
  
• The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation.
  Misra UK, Akabani G, Pizzo SV
  J Biol Chem. 2002
  PubMed ID: 12114513
   
  
• Role of alpha(2)-macroglobulin in fever and cytokine responses induced by lipopolysaccharide in mice.
  Gourine AV, Gourine VN, Tesfaigzi Y, Caluwaerts N, Van Leuven F, Kluger MJ
  Am J Physiol Regul Integr Comp Physiol. 2002
  PubMed ID: 12069948
   
  
• Differential binding properties of human pregnancy zone protein- and alpha2-macroglobulin-proteinase complexes to low-density lipoprotein receptor-related protein.
  Chiabrando GA, Vides MA, Sánchez MC
  Arch Biochem Biophys. 2002
  PubMed ID: 11811950
   
  
• Structure of a rat alpha 1-macroglobulin receptor-binding domain dimer.
  Xiao T, DeCamp DL, Spran SR
  Protein Sci. 2000
  PubMed ID: 11106161
   
  
• Sequence-ready BAC contig, physical, and transcriptional map of a 2-Mb region overlapping the mouse chromosome 6 host-resistance locus Cmv1.
  Depatie C, Lee SH, Stafford A, Avner P, Belouchi A, Gros P, Vidal SM
  Genomics. 2000
  PubMed ID: 10860661
   
  
• alpha2-macroglobulin- and murinoglobulin-1- deficient mice. A mouse model for acute pancreatitis.
  Umans L, Serneels L, Overbergh L, Stas L, Van Leuven F
  Am J Pathol. 1999
  PubMed ID: 10487856
   
  
• Endometrial alpha-2 macroglobulin; localization by in situ hybridization and effect on mouse embryo development in vitro.
  Sayegh RA, Tao XJ, Leykin L, Isaacson KB
  J Clin Endocrinol Metab. 1997
  PubMed ID: 9398738
   
  
• Interaction of matrix metalloproteinases-2 and -9 with pregnancy zone protein and alpha2-macroglobulin.
  Arbeláez LF, Bergmann U, Tuuttila A, Shanbhag VP, Stigbrand T
  Arch Biochem Biophys. 1997
  PubMed ID: 9344465
   
  
• A 2-Mb YAC contig and physical map of the natural killer gene complex on mouse chromosome 6.
  Brown MG, Fulmek S, Matsumoto K, Cho R, Lyons PA, Levy ER, Scalzo AA, Yokoyama WM
  Genomics. 1997
  PubMed ID: 9177771
   
  
• The Cmv1 host resistance locus is closely linked to the Ly49 multigene family within the natural killer cell gene complex on mouse chromosome 6.
  Forbes CA, Brown MG, Cho R, Shellam GR, Yokoyama WM, Scalzo AA
  Genomics. 1997
  PubMed ID: 9169139
   
  
• High-resolution linkage map in the proximity of the host resistance locus Cmv1.
  Depatie C, Muise E, Lepage P, Gros P, Vidal SM
  Genomics. 1997
  PubMed ID: 9027502
   
  
• Murine alpha-macroglobulins demonstrate divergent activities as neutralizers of transforming growth factor-beta and as inducers of nitric oxide synthesis. A possible mechanism for the endotoxin insensitivity of the alpha2-macroglobulin gene knock-out mous
  Webb DJ, Wen J, Lysiak JJ, Umans L, Van Leuven F, Gonias SL
  J Biol Chem. 1996
  PubMed ID: 8798779
   
  
• Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein.
  Valnickova Z, Thogersen IB, Christensen S, Chu CT, Pizzo SV, Enghild JJ
  J Biol Chem. 1996
  PubMed ID: 8662763
   
  
• Embryo implantation in mouse: fetomaternal coordination in the pattern of expression of uPA, uPAR, PAI-1 and alpha 2MR/LRP genes.
  Teesalu T, Blasi F, Talarico D
  Mech Dev. 1996
  PubMed ID: 8798151
   
  
• Preparation and characterization of a C-terminal fragment of pregnancy zone protein corresponding to the receptor-binding peptide from human alpha 2-macroglobulin.
  Jensen PE, Arbelaez LF, Shanbhag VP, Stigbrand T
  Biochim Biophys Acta. 1996
  PubMed ID: 8620037
   
  
• Targeted inactivation of the mouse alpha 2-macroglobulin gene.
  Umans L, Serneels L, Overbergh L, Lorent K, Van Leuven F, Van den Berghe H
  J Biol Chem. 1995
  PubMed ID: 7544347
   
  
• Expression of mouse alpha-macroglobulins, lipoprotein receptor-related protein, LDL receptor, apolipoprotein E, and lipoprotein lipase in pregnancy.
  Overbergh L, Lorent K, Torrekens S, Van Leuven F, Van den Berghe H
  J Lipid Res. 1995
  PubMed ID: 7595098
   
  
• Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase,
  Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F, Van den Berghe H
  Neuroscience. 1995
  PubMed ID: 7542371
   
  
• Molecular analysis of the human and mouse alpha 2M family.
  Van Leuven F, Umans L, Lorent K, Hilliker C, Serneels L, Overbergh L, Stas L, Raymakers L
  Ann N Y Acad Sci. 1994
  PubMed ID: 7524394
   
  
• Molecular cloning of the mouse gene coding for alpha 2-macroglobulin and targeting of the gene in embryonic stem cells.
  Umans L, Serneels L, Hilliker C, Stas L, Overbergh L, De Strooper B, Van Leuven F, Van den Berghe H
  Genomics. 1994
  PubMed ID: 7528166
   
  
• Binding of transforming growth factor-beta (TGF-beta) to pregnancy zone protein (PZP). Comparison to the TGF-beta-alpha 2-macroglobulin interaction.
  Philip A, Bostedt L, Stigbrand T, O'Connor-McCourt MD
  Eur J Biochem. 1994
  PubMed ID: 7513640
   
  
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