BARD1

Summary Top Help

Gene Description:

BRCA1 associated RING domain 1

Synonyms:

BARD1, Bard1, ENSMUSG00000073653, ENSMUSG00000060893

Orthologs:

Human BARD1 (protein-coding), Mouse Bard1 (protein-coding), Rat Bard1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr2:215590370..215674428 (846 kb) View in Genome Browser

(Mouse) NCBIM37 - chr1:71074072..71149720 (75.65 kb) View in Genome Browser

(Rat) RGSC3.4 - chr9:70120151..70198591 (78.44 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for BARD1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for BARD1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: 1

Reactome: None available

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 28

Publications from PubMed Top Help

Publications: 164

E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes.
David Y, Ternette N, Edelmann MJ, Ziv T, Gayer B, Sertchook R, Dadon Y, Kessler BM, Navon A
J Biol Chem. 2011
PubMed ID: 21965653
Lack of association between BARD1 Cys557Ser variant and breast cancer risk: a meta-analysis of 11,870 cases and 7,687 controls.
Ding DP, Zhang Y, Ma WL, He XF, Wang W, Yu HL, Guo YB, Zheng WL
J Cancer Res Clin Oncol. 2011
PubMed ID: 21809034
BRCA1 tumour suppression occurs via heterochromatin-mediated silencing.
Zhu Q, Pao GM, Huynh AM, Suh H, Tonnu N, Nederlof PM, Gage FH, Verma IM
Nature. 2011
PubMed ID: 21901007
BARD1 expression predicts outcome in colon cancer.
Sporn JC, Hothorn T, Jung B
Clin Cancer Res. 2011
PubMed ID: 21693656
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Common genetic variation at BARD1 is not associated with breast cancer risk in BRCA1 or BRCA2 mutation carriers.
Spurdle AB, Marquart L, McGuffog L, Healey S, Sinilnikova O, Wan F, Chen X, Beesley J, Singer CF, Dressler AC, Gschwantler-Kaulich D, Blum JL, Tung N, Weitzel J, Lynch H, Garber J, Easton DF, Peock S, Cook M, Oliver CT, Frost D, Conroy D, Evans DG, Lalloo F, Eeles R, Izatt L, Davidson R, Chu C, Eccles D, Selkirk CG, Daly M, Isaacs C, Stoppa-Lyonnet D, Sinilnikova OM, Buecher B, Belotti M, Mazoyer S, Barjhoux L, Verny-Pierre C, Lasset C, Dreyfus H, Pujol P, Collonge-Rame MA, GEMO Study Collaborators, Rookus MA, Verhoef S, Kriege M, Hoogerbrugge N, Ausems MG, van Os TA, Wijnen J, Devilee P, Meijers-Heijboer HE, Blok MJ, Heikkinen T, Nevanlinna H, Jakubowska A, Lubinski J, Huzarski T, Byrski T, Durocher F, Couch FJ, Lindor NM, Wang X, Thomassen M, Domchek S, Nathanson K, Caligo M, Jernström H, Liljegren A, Ehrencrona H, Karlsson P, SWE-BRCA, Ganz PA, Olopade OI, Tomlinson G, Neuhausen S, Antoniou AC, Chenevix-Trench G, Rebbeck TR
Cancer Epidemiol Biomarkers Prev. 2011
PubMed ID: 21393566
Integrative genomics identifies LMO1 as a neuroblastoma oncogene.
Wang K, Diskin SJ, Zhang H, Attiyeh EF, Winter C, Hou C, Schnepp RW, Diamond M, Bosse K, Mayes PA, Glessner J, Kim C, Frackelton E, Garris M, Wang Q, Glaberson W, Chiavacci R, Nguyen L, Jagannathan J, Saeki N, Sasaki H, Grant SF, Iolascon A, Mosse YP, Cole KA, Li H, Devoto M, McGrady PW, London WB, Capasso M, Rahman N, Hakonarson H, Maris JM
Nature. 2011
PubMed ID: 21124317
BARD1 homozygous deletion, a possible alternative to BRCA1 mutation in basal breast cancer.
Sabatier R, Adélaïde J, Finetti P, Ferrari A, Huiart L, Sobol H, Chaffanet M, Birnbaum D, Bertucci F
Genes Chromosomes Cancer. 2010
PubMed ID: 20842729
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function.
Wu-Baer F, Ludwig T, Baer R
Mol Cell Biol. 2010
PubMed ID: 20351172
Negative feedback loop of BRCA1-BARD1 ubiquitin ligase on estrogen receptor alpha stability and activity antagonized by cancer-associated isoform of BARD1.
Dizin E, Irminger-Finger I
Int J Biochem Cell Biol. 2010
PubMed ID: 20060929
BARD1, a possible biomarker for breast and ovarian cancer.
Irminger-Finger I
Gynecol Oncol. 2010
PubMed ID: 19959210
Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.
Loizidou MA, Cariolou MA, Neuhausen SL, Newbold RF, Bashiardes E, Marcou Y, Michael T, Daniel M, Kakouri E, Papadopoulos P, Malas S, Hadjisavvas A, Kyriacou K
Breast Cancer Res Treat. 2010
PubMed ID: 19714462
BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription.
Harte MT, O'Brien GJ, Ryan NM, Gorski JJ, Savage KI, Crawford NT, Mullan PB, Harkin DP
Cancer Res. 2010
PubMed ID: 20215511
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
Cancer predisposing missense and protein truncating BARD1 mutations in non-BRCA1 or BRCA2 breast cancer families.
De Brakeleer S, De Grève J, Loris R, Janin N, Lissens W, Sermijn E, Teugels E
Hum Mutat. 2010
PubMed ID: 20077502
Differential modulation of BRCA1 and BARD1 nuclear localisation and foci assembly by DNA damage.
Brodie KM, Henderson BR
Cell Signal. 2010
PubMed ID: 19796682
PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells.
Hammond-Martel I, Pak H, Yu H, Rouget R, Horwitz AA, Parvin JD, Drobetsky EA, Affar el B
PLoS One. 2010
PubMed ID: 21103343
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells.
Ueki T, Park JH, Nishidate T, Kijima K, Hirata K, Nakamura Y, Katagiri T
Cancer Res. 2009
PubMed ID: 19887602
A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.
Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD
Postgrad Med J. 2009
PubMed ID: 19789190
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Polymorphisms in HPV E6/E7 protein interacted genes and risk of cervical cancer in Chinese women: a case-control analysis.
Zhou X, Han S, Wang S, Chen X, Dong J, Shi X, Xia Y, Wang X, Hu Z, Shen H
Gynecol Oncol. 2009
PubMed ID: 19482343
Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.
Kweekel DM, Antonini NF, Nortier JW, Punt CJ, Gelderblom H, Guchelaar HJ
Br J Cancer. 2009
PubMed ID: 19536092
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.
Rebbeck TR, Mitra N, Domchek SM, Wan F, Chuai S, Friebel TM, Panossian S, Spurdle A, Chenevix-Trench G, kConFab, Singer CF, Pfeiler G, Neuhausen SL, Lynch HT, Garber JE, Weitzel JN, Isaacs C, Couch F, Narod SA, Rubinstein WS, Tomlinson GE, Ganz PA, Olopade OI, Tung N, Blum JL, Greenberg R, Nathanson KL, Daly MB
Cancer Res. 2009
PubMed ID: 19584272
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Common variations in BARD1 influence susceptibility to high-risk neuroblastoma.
Capasso M, Devoto M, Hou C, Asgharzadeh S, Glessner JT, Attiyeh EF, Mosse YP, Kim C, Diskin SJ, Cole KA, Bosse K, Diamond M, Laudenslager M, Winter C, Bradfield JP, Scott RH, Jagannathan J, Garris M, McConville C, London WB, Seeger RC, Grant SF, Li H, Rahman N, Rappaport E, Hakonarson H, Maris JM
Nat Genet. 2009
PubMed ID: 19412175
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
Liver X receptor ligands suppress ubiquitination and degradation of LXRalpha by displacing BARD1/BRCA1.
Kim KH, Yoon JM, Choi AH, Kim WS, Lee GY, Kim JB
Mol Endocrinol. 2009
PubMed ID: 19164445
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.
Wang B, Hurov K, Hofmann K, Elledge SJ
Genes Dev. 2009
PubMed ID: 19261749
MERIT40 facilitates BRCA1 localization and DNA damage repair.
Feng L, Huang J, Chen J
Genes Dev. 2009
PubMed ID: 19261748
Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2.
Ryser S, Dizin E, Jefford CE, Delaval B, Gagos S, Christodoulidou A, Krause KH, Birnbaum D, Irminger-Finger I
Cancer Res. 2009
PubMed ID: 19176389
A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.
van Wijk SJ, de Vries SJ, Kemmeren P, Huang A, Boelens R, Bonvin AM, Timmers HT
Mol Syst Biol. 2009
PubMed ID: 19690564
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Genetic sequence variations of BRCA1-interacting genes AURKA, BAP1, BARD1 and DHX9 in French Canadian Families with high risk of breast cancer.
Guénard F, Labrie Y, Ouellette G, Joly Beauparlant C, Durocher F
J Hum Genet. 2009
PubMed ID: 19197335
Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
Mavaddat N, Dunning AM, Ponder BA, Easton DF, Pharoah PD
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19124506
BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity.
Nishikawa H, Wu W, Koike A, Kojima R, Gomi H, Fukuda M, Ohta T
Cancer Res. 2009
PubMed ID: 19117993
Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064572
Common single-nucleotide polymorphisms in DNA double-strand break repair genes and breast cancer risk.
Pooley KA, Baynes C, Driver KE, Tyrer J, Azzato EM, Pharoah PD, Easton DF, Ponder BA, Dunning AM
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064565
Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80.
Wei L, Lan L, Hong Z, Yasui A, Ishioka C, Chiba N
Mol Cell Biol. 2008
PubMed ID: 18936166
The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50.
Edwards RA, Lee MS, Tsutakawa SE, Williams RS, Tainer JA, Glover JN
Biochemistry. 2008
PubMed ID: 18842000
Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: A two-stage Spanish case-control study.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A
Gynecol Oncol. 2008
PubMed ID: 18950845
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Crystal structure of the BARD1 ankyrin repeat domain and its functional consequences.
Fox D, Le Trong I, Rajagopal P, Brzovic PS, Stenkamp RE, Klevit RE
J Biol Chem. 2008
PubMed ID: 18480049
BARD1 regulates BRCA1-mediated transactivation of the p21WAF1/CIP1 and Gadd45 promoters.
Fabbro M, Henderson BR
Cancer Lett. 2008
PubMed ID: 18243530
The BARD1 Cys557Ser polymorphism and breast cancer risk: an Australian case-control and family analysis.
Johnatty SE, Beesley J, Chen X, Hopper JL, Southey MC, Giles GG, Goldgar DE, Chenevix-Trench G, Spurdle AB, The Australian Ovarian Cancer Study Group, The Kathleen Cuningham Consortium for Research in Familial Breast Cancer
Breast Cancer Res Treat. 2008
PubMed ID: 18481171
The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.
Shakya R, Szabolcs M, McCarthy E, Ospina E, Basso K, Nandula S, Murty V, Baer R, Ludwig T
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18443292
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
BARD1 and breast cancer in Poland.
Jakubowska A, Cybulski C, Szymańska A, Huzarski T, Byrski T, Gronwald J, Debniak T, Górski B, Kowalska E, Narod SA, Lubiński J
Breast Cancer Res Treat. 2008
PubMed ID: 17333333
Oncogenic BARD1 isoforms expressed in gynecological cancers.
Li L, Ryser S, Dizin E, Pils D, Krainer M, Jefford CE, Bertoni F, Zeillinger R, Irminger-Finger I
Cancer Res. 2007
PubMed ID: 18089818
Structural requirements for the BARD1 tumor suppressor in chromosomal stability and homology-directed DNA repair.
Laufer M, Nandula SV, Modi AP, Wang S, Jasin M, Murty VV, Ludwig T, Baer R
J Biol Chem. 2007
PubMed ID: 17848578
BARD1 variants are not associated with breast cancer risk in Australian familial breast cancer.
Gorringe KL, Choong DY, Visvader JE, Lindeman GJ, Campbell IG
Breast Cancer Res Treat. 2007
PubMed ID: 17972171
Novel interaction between HPV E6 and BARD1 (BRCA1-associated ring domain 1) and its biologic roles.
Yim EK, Lee KH, Myeong J, Tong SY, Um SJ, Park JS
DNA Cell Biol. 2007
PubMed ID: 17678435
Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase.
Kumaraswamy E, Shiekhattar R
Mol Cell Biol. 2007
PubMed ID: 17664283
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
Identification of novel alternatively spliced BRCA1-associated RING domain (BARD1) messenger RNAs in human peripheral blood lymphocytes and in sporadic breast cancer tissues.
Lombardi G, Falaschi E, Di Cristofano C, Naccarato AG, Sensi E, Aretini P, Roncella M, Bevilacqua G, Caligo MA
Genes Chromosomes Cancer. 2007
PubMed ID: 17497650
CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response.
Kim H, Huang J, Chen J
Nat Struct Mol Biol. 2007
PubMed ID: 17643122
Crystal structure of the BARD1 BRCT domains.
Birrane G, Varma AK, Soni A, Ladias JA
Biochemistry. 2007
PubMed ID: 17550235
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.
Kim H, Chen J, Yu X
Science. 2007
PubMed ID: 17525342
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.
Sobhian B, Shao G, Lilli DR, Culhane AC, Moreau LA, Xia B, Livingston DM, Greenberg RA
Science. 2007
PubMed ID: 17525341
Molecular haplotyping of tandem single nucleotide polymorphisms by allele-specific PCR.
Cañadas C, Sánchez-de-Abajo A, Fernández JM, Martín M, Diaz-Rubio E, Caldés T, de la Hoya M
Anal Biochem. 2007
PubMed ID: 17399677
Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility: a case-control analysis.
Huo X, Hu Z, Zhai X, Wang Y, Wang S, Wang X, Qin J, Chen W, Jin G, Liu J, Gao J, Wei Q, Wang X, Shen H
Breast Cancer Res Treat. 2007
PubMed ID: 17028982
Estrogen receptor alpha regulates expression of the breast cancer 1 associated ring domain 1 (BARD1) gene through intronic DNA sequence.
Creekmore AL, Ziegler YS, Bonéy JL, Nardulli AM
Mol Cell Endocrinol. 2007
PubMed ID: 17275994
Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry.
Denis NJ, Vasilescu J, Lambert JP, Smith JC, Figeys D
Proteomics. 2007
PubMed ID: 17370265
Ubiquitination and proteasome-mediated degradation of BRCA1 and BARD1 during steroidogenesis in human ovarian granulosa cells.
Lu Y, Amleh A, Sun J, Jin X, McCullough SD, Baer R, Ren D, Li R, Hu Y
Mol Endocrinol. 2007
PubMed ID: 17185394
BRCA1 ubiquitinates RPB8 in response to DNA damage.
Wu W, Nishikawa H, Hayami R, Sato K, Honda A, Aratani S, Nakajima T, Fukuda M, Ohta T
Cancer Res. 2007
PubMed ID: 17283126
Identification of BARD1 splice-isoforms involved in human trophoblast invasion.
Li L, Cohen M, Wu J, Sow MH, Nikolic B, Bischof P, Irminger-Finger I
Int J Biochem Cell Biol. 2007
PubMed ID: 17556008
Ubiquitin transfer from the E2 perspective: why is UbcH5 so promiscuous?
Brzovic PS, Klevit RE
Cell Cycle. 2006
PubMed ID: 17218787
Nordic collaborative study of the BARD1 Cys557Ser allele in 3956 patients with cancer: enrichment in familial BRCA1/BRCA2 mutation-negative breast cancer but not in other malignancies.
Karppinen SM, Barkardottir RB, Backenhorn K, Sydenham T, Syrjäkoski K, Schleutker J, Ikonen T, Pylkäs K, Rapakko K, Erkko H, Johannesdottir G, Gerdes AM, Thomassen M, Agnarsson BA, Grip M, Kallioniemi A, Kere J, Aaltonen LA, Arason A, Møller P, Kruse TA, Borg A, Winqvist R
J Med Genet. 2006
PubMed ID: 16825437
The BARD1 Cys557Ser variant and breast cancer risk in Iceland.
Stacey SN, Sulem P, Johannsson OT, Helgason A, Gudmundsson J, Kostic JP, Kristjansson K, Jonsdottir T, Sigurdsson H, Hrafnkelsson J, Johannsson J, Sveinsson T, Myrdal G, Grimsson HN, Bergthorsson JT, Amundadottir LT, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K
PLoS Med. 2006
PubMed ID: 16768547
BARD1 content correlates with increased DNA fragmentation associated with muscle wasting in tumour-bearing rats.
Irminger-Finger I, Busquets S, Calabrio F, López-Soriano FJ, Argilés JM
Oncol Rep. 2006
PubMed ID: 16685375
Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosis.
Wu JY, Vlastos AT, Pelte MF, Caligo MA, Bianco A, Krause KH, Laurent GJ, Irminger-Finger I
Int J Cancer. 2006
PubMed ID: 16152612
BRCA1 DNA-binding activity is stimulated by BARD1.
Simons AM, Horwitz AA, Starita LM, Griffin K, Williams RS, Glover JN, Parvin JD
Cancer Res. 2006
PubMed ID: 16489000
BARD1 variants Cys557Ser and Val507Met in breast cancer predisposition.
Vahteristo P, Syrjäkoski K, Heikkinen T, Eerola H, Aittomäki K, von Smitten K, Holli K, Blomqvist C, Kallioniemi OP, Nevanlinna H
Eur J Hum Genet. 2006
PubMed ID: 16333312
SNP-SNP interactions in breast cancer susceptibility.
Onay VU, Briollais L, Knight JA, Shi E, Wang Y, Wells S, Li H, Rajendram I, Andrulis IL, Ozcelik H
BMC Cancer. 2006
PubMed ID: 16672066
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.
Greenberg RA, Sobhian B, Pathania S, Cantor SB, Nakatani Y, Livingston DM
Genes Dev. 2006
PubMed ID: 16391231
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking.
Henderson BR
Bioessays. 2005
PubMed ID: 16108063
Identification and characterization of missense alterations in the BRCA1 associated RING domain (BARD1) gene in breast and ovarian cancer.
Sauer MK, Andrulis IL
J Med Genet. 2005
PubMed ID: 16061562
BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II.
Starita LM, Horwitz AA, Keogh MC, Ishioka C, Parvin JD, Chiba N
J Biol Chem. 2005
PubMed ID: 15886201
Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells.
Choudhury AD, Xu H, Modi AP, Zhang W, Ludwig T, Baer R
J Biol Chem. 2005
PubMed ID: 15855157
BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase.
Feki A, Jefford CE, Berardi P, Wu JY, Cartier L, Krause KH, Irminger-Finger I
Oncogene. 2005
PubMed ID: 15782130
BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.
Kleiman FE, Wu-Baer F, Fonseca D, Kaneko S, Baer R, Manley JL
Genes Dev. 2005
PubMed ID: 15905410
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
Nature. 2005
PubMed ID: 15815621
Nuclear targeting and cell cycle regulatory function of human BARD1.
Schüchner S, Tembe V, Rodriguez JA, Henderson BR
J Biol Chem. 2005
PubMed ID: 15632137
Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2.
Hayami R, Sato K, Wu W, Nishikawa T, Hiroi J, Ohtani-Kaneko R, Fukuda M, Ohta T
Cancer Res. 2005
PubMed ID: 15665273
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
BARD1 expression during spermatogenesis is associated with apoptosis and hormonally regulated.
Feki A, Jefford CE, Jefford CE, Durand P, Harb J, Lucas H, Krause KH, Irminger-Finger I
Biol Reprod. 2004
PubMed ID: 15240424
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE
Mol Cell. 2004
PubMed ID: 15383276
Mutation screening of the BARD1 gene: evidence for involvement of the Cys557Ser allele in hereditary susceptibility to breast cancer.
Karppinen SM, Heikkinen K, Rapakko K, Winqvist R
J Med Genet. 2004
PubMed ID: 15342711
BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention.
Fabbro M, Schuechner S, Au WW, Henderson BR
Exp Cell Res. 2004
PubMed ID: 15265711
Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase.
Sato K, Hayami R, Wu W, Nishikawa T, Nishikawa H, Okuda Y, Ogata H, Fukuda M, Ohta T
J Biol Chem. 2004
PubMed ID: 15184379
BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.
Fabbro M, Savage K, Hobson K, Deans AJ, Powell SN, McArthur GA, Khanna KK
J Biol Chem. 2004
PubMed ID: 15159397
Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue.
Reinholz MM, An MW, Johnsen SA, Subramaniam M, Suman VJ, Ingle JN, Roche PC, Spelsberg TC
Breast Cancer Res Treat. 2004
PubMed ID: 15218362
Nuclear-cytoplasmic translocation of BARD1 is linked to its apoptotic activity.
Jefford CE, Feki A, Harb J, Krause KH, Irminger-Finger I
Oncogene. 2004
PubMed ID: 15077185
BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair.
Morris JR, Solomon E
Hum Mol Genet. 2004
PubMed ID: 14976165
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1.
Rodriguez JA, Schüchner S, Au WW, Fabbro M, Henderson BR
Oncogene. 2004
PubMed ID: 14647430
Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase.
Nishikawa H, Ooka S, Sato K, Arima K, Okamoto J, Klevit RE, Fukuda M, Ohta T
J Biol Chem. 2004
PubMed ID: 14638690
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.
Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R
Mol Cell. 2003
PubMed ID: 14636569
BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks.
Westermark UK, Reyngold M, Olshen AB, Baer R, Jasin M, Moynahan ME
Mol Cell Biol. 2003
PubMed ID: 14560035
Mutational analysis of BARD1 in familial breast cancer patients in Japan.
Ishitobi M, Miyoshi Y, Hasegawa S, Egawa C, Tamaki Y, Monden M, Noguchi S
Cancer Lett. 2003
PubMed ID: 14550946
Identification and characterization of NIF3L1 BP1, a novel cytoplasmic interaction partner of the NIF3L1 protein.
Tascou S, Kang TW, Trappe R, Engel W, Burfeind P
Biochem Biophys Res Commun. 2003
PubMed ID: 12951069
The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin.
Wu-Baer F, Lagrazon K, Yuan W, Baer R
J Biol Chem. 2003
PubMed ID: 12890688
BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit.
Benezra M, Chevallier N, Morrison DJ, MacLachlan TK, El-Deiry WS, Licht JD
J Biol Chem. 2003
PubMed ID: 12700228
Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability.
McCarthy EE, Celebi JT, Baer R, Ludwig T
Mol Cell Biol. 2003
PubMed ID: 12832489
3rd Geneva aging workshop 2002: cancer, apoptosis and aging.
Irminger-Finger I
Biochim Biophys Acta. 2003
PubMed ID: 12781370
Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex.
Brzovic PS, Keeffe JR, Nishikawa H, Miyamoto K, Fox D, Fukuda M, Ohta T, Klevit R
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12732733
Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control.
Lou Z, Chini CC, Minter-Dykhouse K, Chen J
J Biol Chem. 2003
PubMed ID: 12611903
Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein.
Xia Y, Pao GM, Chen HW, Verma IM, Hunter T
J Biol Chem. 2003
PubMed ID: 12431996
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains.
Mallery DL, Vandenberg CJ, Hiom K
EMBO J. 2002
PubMed ID: 12485996
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Control of biochemical reactions through supramolecular RING domain self-assembly.
Kentsis A, Gordon RE, Borden KL
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12438698
BRCA1 supports XIST RNA concentration on the inactive X chromosome.
Ganesan S, Silver DP, Greenberg RA, Avni D, Drapkin R, Miron A, Mok SC, Randrianarison V, Brodie S, Salstrom J, Rasmussen TP, Klimke A, Marrese C, Marahrens Y, Deng CX, Feunteun J, Livingston DM
Cell. 2002
PubMed ID: 12419249
Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene to a common tumor suppressor pathway.
Spahn L, Petermann R, Siligan C, Schmid JA, Aryee DN, Kovar H
Cancer Res. 2002
PubMed ID: 12183411
The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme.
Chiba N, Parvin JD
Cancer Res. 2002
PubMed ID: 12154023
Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase.
Chen A, Kleiman FE, Manley JL, Ouchi T, Pan ZQ
J Biol Chem. 2002
PubMed ID: 11927591
BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export.
Fabbro M, Rodriguez JA, Baer R, Henderson BR
J Biol Chem. 2002
PubMed ID: 11925436
BRCA1-dependent and independent functions of BARD1.
Irminger-Finger I, Leung WC
Int J Biochem Cell Biol. 2002
PubMed ID: 11943588
Identification of residues required for the interaction of BARD1 with BRCA1.
Morris JR, Keep NH, Solomon E
J Biol Chem. 2002
PubMed ID: 11773071
BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs.
Fan W, Jin S, Tong T, Zhao H, Fan F, Antinore MJ, Rajasekaran B, Wu M, Zhan Q
J Biol Chem. 2002
PubMed ID: 11777930
Germline mutations of the BRCA1-associated ring domain (BARD1) gene in breast and breast/ovarian families negative for BRCA1 and BRCA2 alterations.
Ghimenti C, Sensi E, Presciuttini S, Brunetti IM, Conte P, Bevilacqua G, Caligo MA
Genes Chromosomes Cancer. 2002
PubMed ID: 11807980
E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints.
Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD
Genes Dev. 2002
PubMed ID: 11799067
Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis.
Irminger-Finger I, Leung WC, Li J, Dubois-Dauphin M, Harb J, Feki A, Jefford CE, Soriano JV, Jaconi M, Montesano R, Krause KH
Mol Cell. 2001
PubMed ID: 11779501
BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions.
Brzovic PS, Meza JE, King MC, Klevit RE
J Biol Chem. 2001
PubMed ID: 11526114
Redistribution of BRCA1 among four different protein complexes following replication blockage.
Chiba N, Parvin JD
J Biol Chem. 2001
PubMed ID: 11504724
Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.
Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE
Nat Struct Biol. 2001
PubMed ID: 11573085
Large-scale identification of mammalian proteins localized to nuclear sub-compartments.
Sutherland HG, Mumford GK, Newton K, Ford LV, Farrall R, Dellaire G, Cáceres JF, Bickmore WA
Hum Mol Genet. 2001
PubMed ID: 11555636
Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1.
Wang Q, Zhang H, Guerrette S, Chen J, Mazurek A, Wilson T, Slupianek A, Skorski T, Fishel R, Greene MI
Oncogene. 2001
PubMed ID: 11498787
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation.
Hashizume R, Fukuda M, Maeda I, Nishikawa H, Oyake D, Yabuki Y, Ogata H, Ohta T
J Biol Chem. 2001
PubMed ID: 11278247
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.
Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S, Wahrer DC, Sgroi DC, Lane WS, Haber DA, Livingston DM
Cell. 2001
PubMed ID: 11301010
The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression.
Kleiman FE, Manley JL
Cell. 2001
PubMed ID: 11257228
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Assignment of the BRCA1-associated RING domain gene (Bard1) to rat chromosome 9q34 by in situ hybridization and radiation hybrid mapping.
Gratas C, Meflah K, Harb J, Van Vooren P, Szpirer J, Szpirer C
Cytogenet Cell Genet. 2001
PubMed ID: 11856892
Identification of an apoptotic cleavage product of BARD1 as an autoantigen: a potential factor in the antitumoral response mediated by apoptotic bodies.
Gautier F, Irminger-Finger I, Grégoire M, Meflah K, Harb J
Cancer Res. 2000
PubMed ID: 11156388
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor.
Yu X, Baer R
J Biol Chem. 2000
PubMed ID: 10764811
Genetic analysis of BRCA1 function in a defined tumor cell line.
Scully R, Ganesan S, Vlasakova K, Chen J, Socolovsky M, Livingston DM
Mol Cell. 1999
PubMed ID: 10635334
Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.
Kleiman FE, Manley JL
Science. 1999
PubMed ID: 10477523
The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.
Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A
Oncogene. 1999
PubMed ID: 10362352
Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1.
Meza JE, Brzovic PS, King MC, Klevit RE
J Biol Chem. 1999
PubMed ID: 10026184
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein.
Ayi TC, Tsan JT, Hwang LY, Bowcock AM, Baer R
Oncogene. 1998
PubMed ID: 9798686
BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells.
Wang Q, Zhang H, Kajino K, Greene MI
Oncogene. 1998
PubMed ID: 9788437
The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression.
Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R
J Biol Chem. 1998
PubMed ID: 9738006
Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers.
Thai TH, Du F, Tsan JT, Jin Y, Phung A, Spillman MA, Massa HF, Muller CY, Ashfaq R, Mathis JM, Miller DS, Trask BJ, Baer R, Bowcock AM
Hum Mol Genet. 1998
PubMed ID: 9425226
Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains.
Jin Y, Xu XL, Yang MC, Wei F, Ayi TC, Bowcock AM, Baer R
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9342365
Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
Gene. 1997
PubMed ID: 9373149
Identification of a RING protein that can interact in vivo with the BRCA1 gene product.
Wu LC, Wang ZW, Tsan JT, Spillman MA, Phung A, Xu XL, Yang MC, Hwang LY, Bowcock AM, Baer R
Nat Genet. 1996
PubMed ID: 8944023
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
PubMed ID: 8125298

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	580	12021	64557
EnsEMBL Gene(s)	ENSG00000138376	ENSMUSG00000026196	ENSRNOG00000014960
Unigene	Hs.591642	Mm.10764	Rn.48735
Homologene	BARD1	Bard1	Bard1
OMIM	601593	N/A	N/A
GeneCards	BARD1	N/A	N/A
Beta Cell Genomics	DT.414602	DT.103561134	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	580	12021	64557

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
BARD1	NR1H3	BioGRID	empirical	19164445
BARD1	RAD50	BioGRID	empirical	16391231
BARD1	KAT5	HPRD, MINT, IntAct	empirical	15383276
BARD1	TCERG1	HPRD, MINT, IntAct, BioGRID	empirical	15383276
BARD1	CBX1	IntAct	empirical	21888893
BARD1	CHD3	MINT, IntAct	empirical	15383276
BARD1	TOPBP1	BioGRID	empirical	16391231
BARD1	KAT7	HPRD, MINT, IntAct, BioGRID	empirical	15383276
BARD1	ZHX1	HPRD, MINT, IntAct	empirical	15383276
BARD1	CSTF1	HPRD, IntAct, BioGRID	empirical	10477523 11257228
BARD1	CSTF2	IntAct, BioGRID	empirical	10477523 11257228
BARD1	UBE2U	IntAct, BioGRID	empirical	19690564
BARD1	ESR1	BioGRID	empirical	20060929
BARD1	EWSR1	HPRD, BioGRID	empirical	12183411
BARD1	XRCC6	HPRD, IntAct, BioGRID	empirical	15782130
BARD1	POLR1A	IntAct	empirical	10477523
BARD1	GIT1	HPRD, MINT, IntAct, BioGRID	empirical	15383276
BARD1	BRD7	HPRD, MINT, IntAct	empirical	15383276
BARD1	MSH6	BioGRID	empirical	11498787 16391231
BARD1	H2AFX	BioGRID	empirical	12485996 11927591
BARD1	HTT	BioGRID	empirical	15383276
BARD1	HIST2H2AB	BioGRID	empirical	11927591
BARD1	MLH1	BioGRID	empirical	16391231
BARD1	MSH2	HPRD, BioGRID	empirical	11498787
BARD1	MSH3	BioGRID	empirical	11498787
BARD1	NBN	BioGRID	empirical	16391231
BARD1	NFKBIA	BioGRID	empirical	10362352
BARD1	NPM1	BioGRID	empirical	15184379
BARD1	PCBD1	BioGRID	empirical	20211142
BARD1	UBXN1	BioGRID	empirical	20351172
BARD1	PCNA	IntAct	empirical	10477523
BARD1	PIAS4	HPRD, MINT, IntAct	empirical	15383276
BARD1	UIMC1	IntAct, BioGRID	empirical	19615732 17525341
BARD1	POLR2A	HPRD	empirical	12154023
BARD1	POLR2H	BioGRID	empirical	17283126
BARD1	POU2F1	HPRD	empirical	11777930
BARD1	LRIF1	MINT, IntAct	empirical	15383276
BARD1	BACH1	BioGRID	empirical	17664283 16391231
BARD1	KIAA1377	MINT, IntAct	empirical	15383276
BARD1	PTN	HPRD, MINT, IntAct	empirical	15383276
BARD1	BARD1	HPRD, BioGRID	empirical	10026184 11257228 16391231 21965653
BARD1	RAD51	BioGRID	empirical	14636569
BARD1	RBBP8	HPRD, BioGRID	empirical	10764811 16391231 20351172
BARD1	RELA	BioGRID	empirical	12700228
BARD1	BCL3	HPRD, BioGRID	empirical	10362352
BARD1	BRCA1	HPRD, MINT, IntAct, BioGRID, Sanger Interaction Map	empirical	8944023 10026184 11773071 12431996 11573085 15265711 11278247 15184379 12438698 9342365 12419249 10477523 11498787 12485996 12890688 11925436 14647430 12732733 14638690 14636569 11504724 11257228 11526114 11927591 15159397 9738006 10635334 12951069 12700228 11301010 9788437 19176389 19117993 17525341 20215511 16489000 18936166 17664283 20060929 16391231 20351172 21901007 15345047
BARD1	TACC1	BioGRID	empirical	19176389
BARD1	TP53	HPRD, IntAct, BioGRID	empirical	15782130 14636569
BARD1	UBC	BioGRID	empirical	17218787 21965653 21890473
BARD1	UBA1	BioGRID	empirical	12485996 12438698 11927591 12431996 11278247
BARD1	UBE2D1	BioGRID	empirical	12485996 12438698 11927591 14636569 12890688 11278247
BARD1	UBE2D2	BioGRID	empirical	12431996
BARD1	UBE2I	Sanger Interaction Map	predicted	15345047
BARD1	SUMO1	Sanger Interaction Map	predicted	15345047
BARD1	XRCC5	BioGRID	empirical	18936166
BARD1	BRCC3	BioGRID	empirical	14636569 17525341 17664283
BARD1	SMC1A	BioGRID	empirical	16391231
BARD1	KBTBD7	MINT, IntAct	empirical	15383276
BARD1	FAM175A	BioGRID	empirical	19261749 19261748
BARD1	ING5	HPRD, MINT, IntAct	empirical	15383276
BARD1	IKBKAP	HPRD, MINT, IntAct	empirical	15383276
BARD1	HAP1	MINT, IntAct	empirical	15383276
BARD1	MED17	BioGRID	empirical	12154023
BARD1	BRE	BioGRID	empirical	14636569
BARD1	FEZ1	HPRD, MINT, IntAct	empirical	15383276
BARD1	MDC1	HPRD	empirical	12611903
BARD1	SETDB1	HPRD, MINT, IntAct	empirical	15383276