PTPN6

Summary Top Help

Gene Description:

protein tyrosine phosphatase, non-receptor type 6

Synonyms:

motheaten, Hcph, Ptpn6, Ptph6, SH-PTP1, me, PTP-1C, HCPH, SHP1, Ptp1C, PTPN6, SHP-1, SHP-1L, HCP, hcp, Shp-1, HPTP1C

Orthologs:

Human PTPN6 (protein-coding), Mouse Ptpn6 (protein-coding), Rat Ptpn6 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1 Rat: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd19	Mouse	chr6:117439553..128469043	11.03	187	2 no lod score

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm14	Rat	chr4:63276741..160891592	97.61	815

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr12:7055631..7070479 (14.85 kb) View in Genome Browser

(Mouse) NCBIM37 - chr6:124670725..124688732 (181 kb) View in Genome Browser

(Rat) RGSC3.4 - chr4:160843699..160868856 (25.16 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PTPN6:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PTPN6:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 6

Biocarta: 5

Reactome: 15

NCI-Nature Pathway Interaction Database: 10

Gene Ontology: 30

Publications from PubMed Top Help

Publications: 464

Inhibition of the protein tyrosine phosphatase SHP-1 increases glucose uptake in skeletal muscle cells by augmenting insulin receptor signaling and GLUT4 expression.
Bergeron S, Dubois MJ, Bellmann K, Schwab M, Larochelle N, Nalbantoglu J, Marette A
Endocrinology. 2011
PubMed ID: 21952243
Epithelial-specific methylation marker: a potential plasma biomarker in advanced non-small cell lung cancer.
Vinayanuwattikun C, Sriuranpong V, Tanasanvimon S, Chantranuwat P, Mutirangura A
J Thorac Oncol. 2011
PubMed ID: 21964525
The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin/GHSR1a system.
Lodeiro M, Alén BO, Mosteiro CS, Beiroa D, Nogueiras R, Theodoropoulou M, Pardo M, Gallego R, Pazos Y, Casanueva FF, Camiña JP
Mol Biol Cell. 2011
PubMed ID: 21900501
Reactive oxygen species regulate M-CSF-induced monocyte/macrophage proliferation through SHP1 oxidation.
Choi HK, Kim TH, Jhon GJ, Lee SY
Cell Signal. 2011
PubMed ID: 21664461
SHP-1 expression accounts for resistance to imatinib treatment in Philadelphia chromosome-positive cells derived from patients with chronic myeloid leukemia.
Esposito N, Colavita I, Quintarelli C, Sica AR, Peluso AL, Luciano L, Picardi M, Del Vecchio L, Buonomo T, Hughes TP, White D, Radich JP, Russo D, Branford S, Saglio G, Melo JV, Martinelli R, Ruoppolo M, Kalebic T, Martinelli G, Pane F
Blood. 2011
PubMed ID: 21821701
Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway.
Mittal Y, Pavlova Y, Garcia-Marcos M, Ghosh P
J Biol Chem. 2011
PubMed ID: 21799016
Breast cancer cells proliferation is regulated by tyrosine phosphatase SHP1 through c-jun N-terminal kinase and cooperative induction of RFX-1 and AP-4 transcription factors.
Amin S, Kumar A, Nilchi L, Wright K, Kozlowski M
Mol Cancer Res. 2011
PubMed ID: 21719561
Tyrosine phosphatase SHP-1 is expressed higher in multisystem than in single-system Langerhans cell histiocytosis by immunohistochemistry.
Murakami I, Oka T, Kuwamoto S, Kato M, Hayashi K, Gogusev J, Imamura T, Morimoto A, Imashuku S, Yoshino T
Virchows Arch. 2011
PubMed ID: 21604205
Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation.
Wang W, Liu L, Song X, Mo Y, Komma C, Bellamy HD, Zhao ZJ, Zhou GW
J Cell Biochem. 2011
PubMed ID: 21465528
β-Sitosterol down-regulates some pro-inflammatory signal transduction pathways by increasing the activity of tyrosine phosphatase SHP-1 in J774A.1 murine macrophages.
Valerio M, Awad AB
Int Immunopharmacol. 2011
PubMed ID: 21356343
Phospholipase C-β3 regulates FcɛRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1.
Xiao W, Kashiwakura J, Hong H, Yasudo H, Ando T, Maeda-Yamamoto M, Wu D, Kawakami Y, Kawakami T
Immunity. 2011
PubMed ID: 21683628
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
CD300F blocks both MyD88 and TRIF-mediated TLR signaling through activation of Src homology region 2 domain-containing phosphatase 1.
Lee SM, Kim EJ, Suk K, Lee WH
J Immunol. 2011
PubMed ID: 21536801
The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow.
Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B
Nat Immunol. 2011
PubMed ID: 21423172
IL-6 production is positively regulated by two distinct Src homology domain 2-containing tyrosine phosphatase-1 (SHP-1)-dependent CCAAT/enhancer-binding protein β and NF-κB pathways and an SHP-1-independent NF-κB pathway in lipopolysaccharide-stimulate
Rego D, Kumar A, Nilchi L, Wright K, Huang S, Kozlowski M
J Immunol. 2011
PubMed ID: 21422245
Compartmentalized CDK2 is connected with SHP-1 and β-catenin and regulates insulin internalization.
Fiset A, Xu E, Bergeron S, Marette A, Pelletier G, Siminovitch KA, Olivier M, Beauchemin N, Faure RL
Cell Signal. 2011
PubMed ID: 21262353
Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity.
Fujita Y, Endo S, Takai T, Yamashita T
EMBO J. 2011
PubMed ID: 21364532
Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans.
Nesterovitch AB, Szanto S, Gonda A, Bardos T, Kis-Toth K, Adarichev VA, Olasz K, Ghassemi-Najad S, Hoffman MD, Tharp MD, Mikecz K, Glant TT
Am J Pathol. 2011
PubMed ID: 21435452
Alteration in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6/SHP1) may contribute to neutrophilic dermatoses.
Nesterovitch AB, Gyorfy Z, Hoffman MD, Moore EC, Elbuluk N, Tryniszewska B, Rauch TA, Simon M, Kang S, Fisher GJ, Mikecz K, Tharp MD, Glant TT
Am J Pathol. 2011
PubMed ID: 21406173
The phosphatase SRC homology region 2 domain-containing phosphatase-1 is an intrinsic central regulator of dendritic cell function.
Ramachandran IR, Song W, Lapteva N, Seethammagari M, Slawin KM, Spencer DM, Levitt JM
J Immunol. 2011
PubMed ID: 21357539
Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells.
Ma G, Pan PY, Eisenstein S, Divino CM, Lowell CA, Takai T, Chen SH
Immunity. 2011
PubMed ID: 21376641
Neutrophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease.
Croker BA, Lewis RS, Babon JJ, Mintern JD, Jenne DE, Metcalf D, Zhang JG, Cengia LH, O'Donnell JA, Roberts AW
J Immunol. 2011
PubMed ID: 21160041
Lactation defect in a widely used MMTV-Cre transgenic line of mice.
Yuan T, Wang Y, Pao L, Anderson SM, Gu H
PLoS One. 2011
PubMed ID: 21559430
Inhibitory ITAM signaling traps activating receptors with the phosphatase SHP-1 to form polarized "inhibisome" clusters.
Pfirsch-Maisonnas S, Aloulou M, Xu T, Claver J, Kanamaru Y, Tiwari M, Launay P, Monteiro RC, Blank U
Sci Signal. 2011
PubMed ID: 21505186
How ITAMs inhibit signaling.
Ivashkiv LB
Sci Signal. 2011
PubMed ID: 21505184
SHP-1 in cell-cycle regulation.
López-Ruiz P, Rodriguez-Ubreva J, Cariaga AE, Cortes MA, Colás B
Anticancer Agents Med Chem. 2011
PubMed ID: 21291405
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Deficiency of SHP1 leads to sustained and increased ERK activation in mast cells, thereby inhibiting IL-3-dependent proliferation and cell death.
Nakata K, Suzuki Y, Inoue T, Ra C, Yakura H, Mizuno K
Mol Immunol. 2011
PubMed ID: 21044800
SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein.
Simoneau M, Coulombe G, Vandal G, Vézina A, Rivard N
Cell Signal. 2011
PubMed ID: 20840866
Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease.
Xiao W, Ando T, Wang HY, Kawakami Y, Kawakami T
Blood. 2010
PubMed ID: 20858858
The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cells.
Iype T, Sankarshanan M, Mauldin IS, Mullins DW, Lorenz U
J Immunol. 2010
PubMed ID: 20952680
Role of the protein tyrosine phosphatase SHP-1 in Interleukin-6 regulation of prostate cancer cells.
Tassidis H, Culig Z, Wingren AG, Härkönen P
Prostate. 2010
PubMed ID: 20687222
SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells.
Fowler CC, Pao LI, Blattman JN, Greenberg PD
J Immunol. 2010
PubMed ID: 20696858
An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions.
Hitomi K, Tahara-Hanaoka S, Someya S, Fujiki A, Tada H, Sugiyama T, Shibayama S, Shibuya K, Shibuya A
Nat Immunol. 2010
PubMed ID: 20526344
The tyrosine 343 residue of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions.
Hegazy SA, Wang P, Anand M, Ingham RJ, Gelebart P, Lai R
J Biol Chem. 2010
PubMed ID: 20424160
Hippocampal SH2-containing protein-tyrosine phosphatases are involved in extinction of contextual fear.
Isosaka T, Yuasa S
Neuroreport. 2010
PubMed ID: 20400923
Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signaling and functions.
Abu-Dayyeh I, Hassani K, Westra ER, Mottram JC, Olivier M
Infect Immun. 2010
PubMed ID: 20368344
Deficient SOCS3 and SHP-1 expression in psoriatic T cells.
Eriksen KW, Woetmann A, Skov L, Krejsgaard T, Bovin LF, Hansen ML, Grønbaek K, Billestrup N, Nissen MH, Geisler C, Wasik MA, Ødum N
J Invest Dermatol. 2010
PubMed ID: 20130595
Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase.
Zhou D, Collins CA, Wu P, Brown EJ
J Leukoc Biol. 2010
PubMed ID: 20145200
Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP.
Zhou X, Gallazzini M, Burg MB, Ferraris JD
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20351292
'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection.
Orr MT, Murphy WJ, Lanier LL
Nat Immunol. 2010
PubMed ID: 20190757
Calpain-dependent cleavage of SHP-1 and SHP-2 is involved in the dephosphorylation of Jurkat T cells induced by Entamoeba histolytica.
Kim KA, Lee YA, Shin MH
Parasite Immunol. 2010
PubMed ID: 20398180
The tyrosine phosphatase, SHP-1, is involved in bronchial mucin production during oxidative stress.
Jang MK, Kim SH, Lee KY, Kim TB, Moon KA, Park CS, Bae YJ, Zhu Z, Moon HB, Cho YS
Biochem Biophys Res Commun. 2010
PubMed ID: 20117097
SHP-1 deficient mast cells are hyperresponsive to stimulation and critical in initiating allergic inflammation in the lung.
Zhang L, Oh SY, Wu X, Oh MH, Wu F, Schroeder JT, Takemoto CM, Zheng T, Zhu Z
J Immunol. 2010
PubMed ID: 20042576
Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery.
Rodríguez-Ubreva FJ, Cariaga-Martinez AE, Cortés MA, Romero-De Pablos M, Ropero S, López-Ruiz P, Colás B
Oncogene. 2010
PubMed ID: 19838216
Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation.
Kim DJ, Tremblay ML, Digiovanni J
PLoS One. 2010
PubMed ID: 20421975
5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization.
Sandur SK, Pandey MK, Sung B, Aggarwal BB
Mol Cancer Res. 2010
PubMed ID: 20068065
SHP-1 exhibits a pro-apoptotic function in antigen-stimulated mast cells: positive regulation of mitochondrial death pathways and negative regulation of survival signaling pathways.
Inoue T, Suzuki Y, Mizuno K, Nakata K, Yoshimaru T, Ra C
Mol Immunol. 2009
PubMed ID: 19875169
Protein tyrosine phosphatases expression during development of mouse superior colliculus.
Reinhard J, Horvat-Bröcker A, Illes S, Zaremba A, Knyazev P, Ullrich A, Faissner A
Exp Brain Res. 2009
PubMed ID: 19727691
DNA methylation regulates constitutive expression of Stat6 regulatory genes SOCS-1 and SHP-1 in colon cancer cells.
Xu SB, Liu XH, Li BH, Zhang Y, Yuan J, Yuan Q, Li PD, Yang XZ, Li F, Zhang WJ
J Cancer Res Clin Oncol. 2009
PubMed ID: 19551406
Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.
Nyström A, Shaik ZP, Gullberg D, Krieg T, Eckes B, Zent R, Pozzi A, Iozzo RV
Blood. 2009
PubMed ID: 19789387
The nuclear localization of 3'-phosphoinositide-dependent kinase-1 is dependent on its association with the protein tyrosine phosphatase SHP-1.
Sephton CF, Zhang D, Lehmann TM, Pennington PR, Scheid MP, Mousseau DD
Cell Signal. 2009
PubMed ID: 19591923
Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation.
Montano X
Oncogene. 2009
PubMed ID: 19749791
Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling.
Xiong H, Chen ZF, Liang QC, Du W, Chen HM, Su WY, Chen GQ, Han ZG, Fang JY
J Cell Mol Med. 2009
PubMed ID: 20196786
Siglec-9 and SHP-1 are differentially expressed in neonatal and adult neutrophils.
Rashmi R, Bode BP, Panesar N, King SB, Rudloff JR, Gartner MR, Koenig JM
Pediatr Res. 2009
PubMed ID: 19542910
New variants in the Enpp1 and Ptpn6 genes cause low BMD, crystal-related arthropathy, and vascular calcification.
Babij P, Roudier M, Graves T, Han CY, Chhoa M, Li CM, Juan T, Morony S, Grisanti M, Li X, Yu L, Dwyer D, Lloyd DJ, Bass MB, Richards WG, Ebeling C, Amato J, Carlson G
J Bone Miner Res. 2009
PubMed ID: 19419305
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.
Xiao W, Hong H, Kawakami Y, Kato Y, Wu D, Yasudo H, Kimura A, Kubagawa H, Bertoli LF, Davis RS, Chau LA, Madrenas J, Hsia CC, Xenocostas A, Kipps TJ, Hennighausen L, Iwama A, Nakauchi H, Kawakami T
Cancer Cell. 2009
PubMed ID: 19647226
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG, Smith RD, Wiley HS, Qian WJ
J Proteome Res. 2009
PubMed ID: 19534553
Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype.
Christophi GP, Panos M, Hudson CA, Christophi RL, Gruber RC, Mersich AT, Blystone SD, Jubelt B, Massa PT
Lab Invest. 2009
PubMed ID: 19398961
[As2O3 induces demethylation and up-regulates transcription of SHP-1 gene in human lymphoma cell line T2 cells].
Yang L, Luo JM, Li Y, Liu XJ, Wen SP, Du XY, Yao L, Yang JC, Dong ZR
Zhonghua Zhong Liu Za Zhi. 2009
PubMed ID: 19950550
Differential methylation pattern of ID4, SFRP1, and SHP1 between acute myeloid leukemia and chronic myeloid leukemia.
Uhm KO, Lee ES, Lee YM, Park JS, Kim SJ, Kim BS, Kim HS, Park SH
J Korean Med Sci. 2009
PubMed ID: 19543515
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance.
Gross AJ, Lyandres JR, Panigrahi AK, Prak ET, DeFranco AL
J Immunol. 2009
PubMed ID: 19380785
A critical role of SHP-1 in regulation of type 2 inflammation in the lung.
Oh SY, Zheng T, Kim YK, Cohn L, Homer RJ, McKenzie AN, Zhu Z
Am J Respir Cell Mol Biol. 2009
PubMed ID: 18952567
Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients.
Samanta AK, Chakraborty SN, Wang Y, Kantarjian H, Sun X, Hood J, Perrotti D, Arlinghaus RB
Oncogene. 2009
PubMed ID: 19234487
[Effect of a methylation inhibitor 5-aza-2'-deoxycytidine on SHP-1 gene expression, proliferation and apoptosis in K562 cells].
Luo JM, Li Y, Yang L, Liu XJ, Wen SP, Wang FX, Zhang JY, Zhang XJ, Dong ZR
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009
PubMed ID: 19379557
[Effect of As2O3 on demethylation of SHP-1 gene in human lymphoma cell line T2].
Yang L, Luo JM, Wen SP, Liu XJ, Du XY, Li Y
Ai Zheng. 2009
PubMed ID: 19619438
Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2.
Korporaal SJ, Koekman CA, Verhoef S, van der Wal DE, Bezemer M, Van Eck M, Akkerman JW
Arterioscler Thromb Vasc Biol. 2009
PubMed ID: 19096001
The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo.
Kim HJ, Zhang K, Zhang L, Ross FP, Teitelbaum SL, Faccio R
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19171907
Redox regulation of SH2-domain-containing protein tyrosine phosphatases by two backdoor cysteines.
Chen CY, Willard D, Rudolph J
Biochemistry. 2009
PubMed ID: 19166311
CD8+ T cell responses to a viral escape mutant epitope: active suppression via altered SHP-1 activity.
Schnell FJ, Alberts-Grill N, Evavold BD
J Immunol. 2009
PubMed ID: 19201834
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, Dekosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devrièze F, Dartigues JF, Tzourio C, Buée L, Pasquier F, Berr C, Mann D, Lendon C, Alpérovitch A, Kamboh MI, Amouyel P, Lambert JC
Mol Psychiatry. 2009
PubMed ID: 19204726
IL-10 suppresses CD2-mediated T cell activation via SHP-1.
Taylor A, Verhagen J, Akkoç T, Wenig R, Flory E, Blaser K, Akdis M, Akdis CA
Mol Immunol. 2009
PubMed ID: 18952289
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
Cell. 2009
PubMed ID: 19167335
The role of glucocorticoid in SIRP alpha and SHP-1 gene expression in AIHA patients.
de Almeida AC, Barbosa SM, Barjas-Castro Mde L, Olalla-Saad ST, Condino-Neto A
Immunopharmacol Immunotoxicol. 2009
PubMed ID: 19874234
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1.
Kunnumakkara AB, Nair AS, Sung B, Pandey MK, Aggarwal BB
Mol Cancer Res. 2009
PubMed ID: 19147543
Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases.
Beutler B
Immunol Rev. 2009
PubMed ID: 19120489
Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease.
Christophi GP, Hudson CA, Panos M, Gruber RC, Massa PT
J Virol. 2009
PubMed ID: 18987138
Mechanisms of SHP-1 P2 promoter regulation in hematopoietic cells and its silencing in HTLV-1-transformed T cells.
Nakase K, Cheng J, Zhu Q, Marasco WA
J Leukoc Biol. 2009
PubMed ID: 18948549
Significance of SHP-1 and SHP-2 expression in human papillomavirus infected Condyloma acuminatum and cervical cancer.
Tao XH, Shen JG, Pan WL, Dong YE, Meng Q, Honn KV, Jin R
Pathol Oncol Res. 2008
PubMed ID: 18543080
MHC variant peptide-mediated anergy of encephalitogenic T cells requires SHP-1.
Wasserman HA, Beal CD, Zhang Y, Jiang N, Zhu C, Evavold BD
J Immunol. 2008
PubMed ID: 18981103
Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1.
Nakata K, Yoshimaru T, Suzuki Y, Inoue T, Ra C, Yakura H, Mizuno K
J Immunol. 2008
PubMed ID: 18832698
Involvement of c-Src tyrosine kinase in SHP-1 phosphatase activation by Ang II AT2 receptors in rat fetal tissues.
Alvarez SE, Seguin LR, Villarreal RS, Nahmias C, Ciuffo GM
J Cell Biochem. 2008
PubMed ID: 18680145
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.
Mori Y, Tsuji S, Inui M, Sakamoto Y, Endo S, Ito Y, Fujimura S, Koga T, Nakamura A, Takayanagi H, Itoi E, Takai T
J Immunol. 2008
PubMed ID: 18802077
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation.
Cho YS, Oh SY, Zhu Z
Am J Respir Cell Mol Biol. 2008
PubMed ID: 18441283
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger.
Croker BA, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18806225
TIMP1 induces CD44 expression and the activation and nuclear translocation of SHP1 during the late centrocyte/post-germinal center B cell differentiation.
Kim YS, Seo DW, Kong SK, Lee JH, Lee ES, Stetler-Stevenson M, Stetler-Stevenson WG
Cancer Lett. 2008
PubMed ID: 18502033
Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells.
Simoneau M, Boulanger J, Coulombe G, Renaud MA, Duchesne C, Rivard N
J Biol Chem. 2008
PubMed ID: 18617527
Variability and robustness in T cell activation from regulated heterogeneity in protein levels.
Feinerman O, Veiga J, Dorfman JR, Germain RN, Altan-Bonnet G
Science. 2008
PubMed ID: 18719282
An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.
Yu MC, Su LL, Zou L, Liu Y, Wu N, Kong L, Zhuang ZH, Sun L, Liu HP, Hu JH, Li D, Strominger JL, Zang JW, Pei G, Ge BX
Nat Immunol. 2008
PubMed ID: 18604210
Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II.
Liang B, Workman C, Lee J, Chew C, Dale BM, Colonna L, Flores M, Li N, Schweighoffer E, Greenberg S, Tybulewicz V, Vignali D, Clynes R
J Immunol. 2008
PubMed ID: 18424711
Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1.
An H, Hou J, Zhou J, Zhao W, Xu H, Zheng Y, Yu Y, Liu S, Cao X
Nat Immunol. 2008
PubMed ID: 18391954
Formation of smooth muscle alpha actin filaments in CD34+ bone marrow cells on arterial elastic laminae: potential role of SH2 domain-containing protein tyrosine phosphatase-1.
Liu SQ, Tefft BJ, Zhang A, Zhang LQ, Wu YH
Matrix Biol. 2008
PubMed ID: 18258420
Changes in the expression and dynamics of SHP-1 and SHP-2 during cerulein-induced acute pancreatitis in rats.
Sarmiento N, Sánchez-Bernal C, Ayra M, Pérez N, Hernández-Hernández A, Calvo JJ, Sánchez-Yagüe J
Biochim Biophys Acta. 2008
PubMed ID: 18294464
SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients.
Christophi GP, Hudson CA, Gruber RC, Christophi CP, Mihai C, Mejico LJ, Jubelt B, Massa PT
Lab Invest. 2008
PubMed ID: 18209728
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8.
Jia SH, Parodo J, Kapus A, Rotstein OD, Marshall JC
J Biol Chem. 2008
PubMed ID: 18086677
Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.
Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T
Rheumatology (Oxford). 2008
PubMed ID: 18174230
Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice.
Lee S, Muniyappa R, Yan X, Chen H, Yue LQ, Hong EG, Kim JK, Quon MJ
Am J Physiol Endocrinol Metab. 2008
PubMed ID: 18003716
Novel binding site for Src homology 2-containing protein-tyrosine phosphatase-1 in CD22 activated by B lymphocyte stimulation with antigen.
Zhu C, Sato M, Yanagisawa T, Fujimoto M, Adachi T, Tsubata T
J Biol Chem. 2008
PubMed ID: 18024433
Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif.
Abu-Dayyeh I, Shio MT, Sato S, Akira S, Cousineau B, Olivier M
PLoS Negl Trop Dis. 2008
PubMed ID: 19104650
Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration*.
Bhattacharya R, Kwon J, Wang E, Mukherjee P, Mukhopadhyay D
J Mol Signal. 2008
PubMed ID: 18377662
Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.
Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y
Anal Sci. 2008
PubMed ID: 18187866
Identification of leishmania fructose-1,6-bisphosphate aldolase as a novel activator of host macrophage Src homology 2 domain containing protein tyrosine phosphatase SHP-1.
Nandan D, Tran T, Trinh E, Silverman JM, Lopez M
Biochem Biophys Res Commun. 2007
PubMed ID: 18028878
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
Cao L, Yu K, Banh C, Nguyen V, Ritz A, Raphael BJ, Kawakami Y, Kawakami T, Salomon AR
J Immunol. 2007
PubMed ID: 17947660
CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation.
Pinheiro da Silva F, Aloulou M, Skurnik D, Benhamou M, Andremont A, Velasco IT, Chiamolera M, Verbeek JS, Launay P, Monteiro RC
Nat Med. 2007
PubMed ID: 17934470
Age-related impairment of GM-CSF-induced signalling in neutrophils: role of SHP-1 and SOCS proteins.
Tortorella C, Simone O, Piazzolla G, Stella I, Antonaci S
Ageing Res Rev. 2007
PubMed ID: 17142110
B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity.
Pao LI, Lam KP, Henderson JM, Kutok JL, Alimzhanov M, Nitschke L, Thomas ML, Neel BG, Rajewsky K
Immunity. 2007
PubMed ID: 17600736
Identification of a novel lipid raft-targeting motif in Src homology 2-containing phosphatase 1.
Sankarshanan M, Ma Z, Iype T, Lorenz U
J Immunol. 2007
PubMed ID: 17579069
Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2.
Weibrecht I, Böhmer SA, Dagnell M, Kappert K, Ostman A, Böhmer FD
Free Radic Biol Med. 2007
PubMed ID: 17561098
Regulation of growth hormone signaling by selective estrogen receptor modulators occurs through suppression of protein tyrosine phosphatases.
Leung KC, Brce J, Doyle N, Lee HJ, Leong GM, Sjögren K, Ho KK
Endocrinology. 2007
PubMed ID: 17272397
Immune complexes suppress IFN-gamma signaling by activation of the FcgammaRI pathway.
Boekhoudt GH, Frazier-Jessen MR, Feldman GM
J Leukoc Biol. 2007
PubMed ID: 17227821
PU.1 activates transcription of SHP-1 gene in hematopoietic cells.
Wlodarski P, Zhang Q, Liu X, Kasprzycka M, Marzec M, Wasik MA
J Biol Chem. 2007
PubMed ID: 17218319
Loss of SHP-1 tyrosine phosphatase expression correlates with the advanced stages of cutaneous T-cell lymphoma.
Witkiewicz A, Raghunath P, Wasik A, Junkins-Hopkins JM, Jones D, Zhang Q, Odum N, Wasik MA
Hum Pathol. 2007
PubMed ID: 17239936
Late signaling in the activated platelets upregulates tyrosine phosphatase SHP1 and impairs platelet adhesive functions: Regulation by calcium and Src kinase.
Gupta R, Chakrabarti P, Dikshit M, Dash D
Biochim Biophys Acta. 2007
PubMed ID: 17046078
Scarcity of lambda 1 B cells in mice with a single point mutation in C lambda 1 is due to a low BCR signal caused by misfolded lambda 1 light chain.
Volgina VV, Sun T, Bozek G, Martin TE, Storb U
Mol Immunol. 2007
PubMed ID: 16860389
SHP-1 tyrosine phosphatase in human erythrocytes.
Bragadin M, Ion-Popa F, Clari G, Bordin L
Ann N Y Acad Sci. 2007
PubMed ID: 17404032
FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin.
Park-Min KH, Serbina NV, Yang W, Ma X, Krystal G, Neel BG, Nutt SL, Hu X, Ivashkiv LB
Immunity. 2007
PubMed ID: 17239631
Loss of Src homology region 2 domain-containing protein tyrosine phosphatase-1 increases CD8+ T cell-APC conjugate formation and is associated with enhanced in vivo CTL function.
Sathish JG, Dolton G, Leroy FG, Matthews RJ
J Immunol. 2007
PubMed ID: 17182570
Germline gain-of-function mutations in SOS1 cause Noonan syndrome.
Roberts AE, Araki T, Swanson KD, Montgomery KT, Schiripo TA, Joshi VA, Li L, Yassin Y, Tamburino AM, Neel BG, Kucherlapati RS
Nat Genet. 2007
PubMed ID: 17143285
Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway.
Kajino T, Ren H, Iemura S, Natsume T, Stefansson B, Brautigan DL, Matsumoto K, Ninomiya-Tsuji J
J Biol Chem. 2006
PubMed ID: 17079228
Role of host protein tyrosine phosphatase SHP-1 in Leishmania donovani-induced inhibition of nitric oxide production.
Forget G, Gregory DJ, Whitcombe LA, Olivier M
Infect Immun. 2006
PubMed ID: 17057094
Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation.
Udell CM, Samayawardhena LA, Kawakami Y, Kawakami T, Craig AW
J Biol Chem. 2006
PubMed ID: 16731527
SHP protein tyrosine phosphatase expression in rat uterine tissue.
Phillippe M, Bradley DF, Engle D, Sweet L
J Soc Gynecol Investig. 2006
PubMed ID: 16814162
ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signaling.
Grewal PK, Boton M, Ramirez K, Collins BE, Saito A, Green RS, Ohtsubo K, Chui D, Marth JD
Mol Cell Biol. 2006
PubMed ID: 16782884
Inverse regulation of inducible nitric oxide synthase (iNOS) and arginase I by the protein tyrosine phosphatase SHP-1 in CNS glia.
Bonaparte KL, Hudson CA, Wu C, Massa PT
Glia. 2006
PubMed ID: 16565987
Motheaten (me/me) mice deficient in SHP-1 are less susceptible to focal cerebral ischemia.
Beamer CA, Brooks DM, Lurie DI
J Neurosci Res. 2006
PubMed ID: 16528752
The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis.
Dubois MJ, Bergeron S, Kim HJ, Dombrowski L, Perreault M, Fournès B, Faure R, Olivier M, Beauchemin N, Shulman GI, Siminovitch KA, Kim JK, Marette A
Nat Med. 2006
PubMed ID: 16617349
Increased negative selection impairs neonatal B cell repertoire but does not directly lead to generation of disease-associated IgM auto-antibodies.
Cassady-Cain RL, Kaushik AK
Int Immunol. 2006
PubMed ID: 16569683
Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions.
Fortin CF, Larbi A, Lesur O, Douziech N, Fulop T
J Leukoc Biol. 2006
PubMed ID: 16501054
SHP-1 inhibits LPS-mediated TNF and iNOS production in murine macrophages.
Hardin AO, Meals EA, Yi T, Knapp KM, English BK
Biochem Biophys Res Commun. 2006
PubMed ID: 16487932
The finished DNA sequence of human chromosome 12.
Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA, Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
Nature. 2006
PubMed ID: 16541075
JAK/STAT signal transduction: regulators and implication in hematological malignancies.
Valentino L, Pierre J
Biochem Pharmacol. 2006
PubMed ID: 16426581
Deficiency of SHP-1 protein-tyrosine phosphatase in "viable motheaten" mice results in retinal degeneration.
Lyons BL, Smith RS, Hurd RE, Hawes NL, Burzenski LM, Nusinowitz S, Hasham MG, Chang B, Shultz LD
Invest Ophthalmol Vis Sci. 2006
PubMed ID: 16505059
Binding specificity of Toll-like receptor cytoplasmic domains.
Brown V, Brown RA, Ozinsky A, Hesselberth JR, Fields S
Eur J Immunol. 2006
PubMed ID: 16482509
Involvement of a tissue-specific autoantibody in skin disorders of murine systemic lupus erythematosus and autoinflammatory diseases.
Nishimura H, Strominger JL
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16492738
Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells.
Seo DW, Li H, Qu CK, Oh J, Kim YS, Diaz T, Wei B, Han JW, Stetler-Stevenson WG
J Biol Chem. 2006
PubMed ID: 16326706
Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A.
Nozaki M, Sakurai E, Raisler BJ, Baffi JZ, Witta J, Ogura Y, Brekken RA, Sage EH, Ambati BK, Ambati J
J Clin Invest. 2006
PubMed ID: 16453023
Lipopolysaccharide-activated SHP-1-deficient motheaten microglia release increased nitric oxide, TNF-alpha, and IL-1beta.
Zhao J, Brooks DM, Lurie DI
Glia. 2006
PubMed ID: 16265671
Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1.
Tsui FW, Martin A, Wang J, Tsui HW
Immunol Res. 2006
PubMed ID: 17003515
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Transcriptome analysis of human gastric cancer.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS
Mamm Genome. 2005
PubMed ID: 16341674
RNA interference targeting SHP-1 attenuates myocardial infarction in rats.
Sugano M, Tsuchida K, Hata T, Makino N
FASEB J. 2005
PubMed ID: 16223786
Negative regulation of monocyte adhesion to arterial elastic laminae by signal regulatory protein alpha and Src homology 2 domain-containing protein-tyrosine phosphatase-1.
Liu SQ, Alkema PK, Tieché C, Tefft BJ, Liu DZ, Li YC, Sumpio BE, Caprini JA, Paniagua M
J Biol Chem. 2005
PubMed ID: 16159885
Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.
Roskoski R
Biochem Biophys Res Commun. 2005
PubMed ID: 16129412
TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1.
Park IK, Shultz LD, Letterio JJ, Gorham JD
J Immunol. 2005
PubMed ID: 16237056
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Deficiency of the Src homology region 2 domain-containing phosphatase 1 (SHP-1) causes enrichment of CD4+CD25+ regulatory T cells.
Carter JD, Calabrese GM, Naganuma M, Lorenz U
J Immunol. 2005
PubMed ID: 15905501
SRC homology-2-containing protein tyrosine phosphatase-1 restrains cell proliferation in human medullary thyroid carcinoma.
Zatelli MC, Piccin D, Tagliati F, Bottoni A, Luchin A, degli Uberti EC
Endocrinology. 2005
PubMed ID: 15746253
Tyrosine phosphatase SHP-1 acts at different stages of development to regulate hematopoiesis.
Paling NR, Welham MJ
Blood. 2005
PubMed ID: 15701718
STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.
Zhang Q, Wang HY, Marzec M, Raghunath PN, Nagasawa T, Wasik MA
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15870198
Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases.
Schmidt-Arras DE, Böhmer A, Markova B, Choudhary C, Serve H, Böhmer FD
Mol Cell Biol. 2005
PubMed ID: 15831474
Localization of Src homology 2 domain-containing phosphatase 1 (SHP-1) to lipid rafts in T lymphocytes: functional implications and a role for the SHP-1 carboxyl terminus.
Fawcett VC, Lorenz U
J Immunol. 2005
PubMed ID: 15728495
FLT3/ITD mutation signaling includes suppression of SHP-1.
Chen P, Levis M, Brown P, Kim KT, Allebach J, Small D
J Biol Chem. 2005
PubMed ID: 15574429
Analysis of SHP-1-mediated down-regulation of the TRK-T3 oncoprotein identifies Trk-fused gene (TFG) as a novel SHP-1-interacting protein.
Roccato E, Miranda C, Raho G, Pagliardini S, Pierotti MA, Greco A
J Biol Chem. 2005
PubMed ID: 15557341
The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.
Zhang H, Meng F, Chu CL, Takai T, Lowell CA
Immunity. 2005
PubMed ID: 15723811
IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor.
Huang Z, Xin J, Coleman J, Huang H
J Immunol. 2005
PubMed ID: 15661890
Abnormal Th1 cell differentiation and IFN-gamma production in T lymphocytes from motheaten viable mice mutant for Src homology 2 domain-containing protein tyrosine phosphatase-1.
Yu WM, Wang S, Keegan AD, Williams MS, Qu CK
J Immunol. 2005
PubMed ID: 15634925
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Substrate-trapping techniques in the identification of cellular PTP targets.
Blanchetot C, Chagnon M, Dubé N, Hallé M, Tremblay ML
Methods. 2005
PubMed ID: 15588985
Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1.
Harder KW, Quilici C, Naik E, Inglese M, Kountouri N, Turner A, Zlatic K, Tarlinton DM, Hibbs ML
Blood. 2004
PubMed ID: 15339845
The critical role of SRC homology domain 2-containing tyrosine phosphatase-1 in recombinant human erythropoietin hyporesponsive anemia in chronic hemodialysis patients.
Akagi S, Ichikawa H, Okada T, Sarai A, Sugimoto T, Morimoto H, Kihara T, Yano A, Nakao K, Nagake Y, Wada J, Makino H
J Am Soc Nephrol. 2004
PubMed ID: 15579525
IREM-1 is a novel inhibitory receptor expressed by myeloid cells.
Alvarez-Errico D, Aguilar H, Kitzig F, Brckalo T, Sayós J, López-Botet M
Eur J Immunol. 2004
PubMed ID: 15549731
CD22 is a functional ligand for SH2 domain-containing protein-tyrosine phosphatase-1 in primary T cells.
Sathish JG, Walters J, Luo JC, Johnson KG, Leroy FG, Brennan P, Kim KP, Gygi SP, Neel BG, Matthews RJ
J Biol Chem. 2004
PubMed ID: 15364920
Loss of SHP-1 phosphatase alters cytokine expression in the mouse hindbrain following cochlear ablation.
Zhao J, Lurie DI
Cytokine. 2004
PubMed ID: 15341919
Signal transduction via the stem cell factor receptor/c-Kit.
Rönnstrand L
Cell Mol Life Sci. 2004
PubMed ID: 15526160
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Visualization of SHP-1-target interaction.
Biskup C, Böhmer A, Pusch R, Kelbauskas L, Gorshokov A, Majoul I, Lindenau J, Benndorf K, Böhmer FD
J Cell Sci. 2004
PubMed ID: 15456853
Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus.
Jones ML, Craik JD, Gibbins JM, Poole AW
J Biol Chem. 2004
PubMed ID: 15269224
Activated Ets2 is required for persistent inflammatory responses in the motheaten viable model.
Wei G, Guo J, Doseff AI, Kusewitt DF, Man AK, Oshima RG, Ostrowski MC
J Immunol. 2004
PubMed ID: 15240733
IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes.
Sui L, Li N, Liu Q, Zhang W, Wan T, Wang B, Luo K, Sun H, Cao X
Biochem Biophys Res Commun. 2004
PubMed ID: 15184070
Dysmyelination and reduced myelin basic protein gene expression by oligodendrocytes of SHP-1-deficient mice.
Massa PT, Wu C, Fecenko-Tacka K
J Neurosci Res. 2004
PubMed ID: 15197735
The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes.
Incoronato M, D'Alessio A, Paladino S, Zurzolo C, Carlomagno MS, Cerchia L, de Franciscis V
Cell Signal. 2004
PubMed ID: 15115663
KIR2DL5 can inhibit human NK cell activation via recruitment of Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2).
Yusa S, Catina TL, Campbell KS
J Immunol. 2004
PubMed ID: 15187115
SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway.
Chim CS, Fung TK, Cheung WC, Liang R, Kwong YL
Blood. 2004
PubMed ID: 14976049
The protein-tyrosine phosphatase SHP-1 regulates the phosphorylation of alpha-actinin.
Lin SY, Raval S, Zhang Z, Deverill M, Siminovitch KA, Branch DR, Haimovich B
J Biol Chem. 2004
PubMed ID: 15070900
Lipopolysaccharide-induced osteoclastogenesis in Src homology 2-domain phosphatase-1-deficient viable motheaten mice.
Hayashi S, Tsuneto M, Yamada T, Nose M, Yoshino M, Shultz LD, Yamazaki H
Endocrinology. 2004
PubMed ID: 14988381
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Cochlear ablation in mice lacking SHP-1 results in an extended period of cell death of anteroventral cochlear nucleus neurons.
Zhao J, Lurie DI
Hear Res. 2004
PubMed ID: 14987753
Regulation of inhibitory protein-kappaB and monocyte chemoattractant protein-1 by angiotensin II type 2 receptor-activated Src homology protein tyrosine phosphatase-1 in fetal vascular smooth muscle cells.
Wu L, Iwai M, Li Z, Shiuchi T, Min LJ, Cui TX, Li JM, Okumura M, Nahmias C, Horiuchi M
Mol Endocrinol. 2004
PubMed ID: 14684844
PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit.
Sozio MS, Mathis MA, Young JA, Wälchli S, Pitcher LA, Wrage PC, Bartók B, Campbell A, Watts JD, Aebersold R, Hooft van Huijsduijnen R, van Oers NS
J Biol Chem. 2004
PubMed ID: 14672952
A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling.
Minoo P, Zadeh MM, Rottapel R, Lebrun JJ, Ali S
Blood. 2004
PubMed ID: 14551136
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells.
Cheng J, Zhang D, Zhou C, Marasco WA
Leuk Res. 2004
PubMed ID: 14630083
CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation.
Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE, Daws MR
J Immunol. 2003
PubMed ID: 14662855
Angiotensin II blocks nicotine-mediated neuroprotection against beta-amyloid (1-42) via activation of the tyrosine phosphatase SHP-1.
Shaw S, Bencherif M, Marrero MB
J Neurosci. 2003
PubMed ID: 14657181
Activated proliferation of B-cell lymphomas/leukemias with the SHP1 gene silencing by aberrant CpG methylation.
Koyama M, Oka T, Ouchida M, Nakatani Y, Nishiuchi R, Yoshino T, Hayashi K, Akagi T, Seino Y
Lab Invest. 2003
PubMed ID: 14691303
The inhibitory potential of Fc receptor homolog 4 on memory B cells.
Ehrhardt GR, Davis RS, Hsu JT, Leu CM, Ehrhardt A, Cooper MD
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14597715
Receptor activator of NF-kappa B ligand stimulates recruitment of SHP-1 to the complex containing TNFR-associated factor 6 that regulates osteoclastogenesis.
Zhang Z, Jimi E, Bothwell AL
J Immunol. 2003
PubMed ID: 14500659
The protein-tyrosine phosphatase SHP-1 associates with the phosphorylated immunoreceptor tyrosine-based activation motif of Fc gamma RIIa to modulate signaling events in myeloid cells.
Ganesan LP, Fang H, Marsh CB, Tridandapani S
J Biol Chem. 2003
PubMed ID: 12832410
Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity.
Stebbins CC, Watzl C, Billadeau DD, Leibson PJ, Burshtyn DN, Long EO
Mol Cell Biol. 2003
PubMed ID: 12917349
Dynamic changes in the expression of protein tyrosine phosphatases during preimplantation mouse development: semi-quantification by real-time PCR.
Hara KT, Sakuma Y, Sakai S, Nagata M, Aoki F
J Reprod Dev. 2003
PubMed ID: 14967925
Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells.
Kumagai H, Oki T, Tamitsu K, Feng SZ, Ono M, Nakajima H, Bao YC, Kawakami Y, Nagayoshi K, Copeland NG, Gilbert DJ, Jenkins NA, Kawakami T, Kitamura T
Biochem Biophys Res Commun. 2003
PubMed ID: 12893283
Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses.
Ishida I, Kumanogoh A, Suzuki K, Akahani S, Noda K, Kikutani H
Int Immunol. 2003
PubMed ID: 12882840
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.
Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM
Nat Immunol. 2003
PubMed ID: 12796776
Interleukin-4 and interleukin-13 signaling connections maps.
Kelly-Welch AE, Hanson EM, Boothby MR, Keegan AD
Science. 2003
PubMed ID: 12791978
The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity.
Westgaard IH, Dissen E, Torgersen KM, Lazetic S, Lanier LL, Phillips JH, Fossum S
J Exp Med. 2003
PubMed ID: 12782717
Insulin receptor substrate-4 signaling in quiescent rat hepatocytes and in regenerating rat liver.
Escribano O, Fernández-Moreno MD, Zueco JA, Menor C, Fueyo J, Ropero RM, Diaz-Laviada I, Román ID, Guijarro LG
Hepatology. 2003
PubMed ID: 12774026
Cutting edge: dependence of TCR antagonism on Src homology 2 domain-containing protein tyrosine phosphatase activity.
Kilgore NE, Carter JD, Lorenz U, Evavold BD
J Immunol. 2003
PubMed ID: 12734331
Decreased expression of Src homology 2 domain-containing protein tyrosine phosphatase 1 reduces T cell activation threshold but not the severity of experimental autoimmune myasthenia gravis.
Deng C, Wu B, Yang H, Hussain RZ, Lovett-Racke AE, Christadoss P, Racke MK
J Neuroimmunol. 2003
PubMed ID: 12742656
Myosin is an in vivo substrate of the protein tyrosine phosphatase (SHP-1) after mIgM cross-linking.
Baba T, Fusaki N, Shinya N, Iwamatsu A, Hozumi N
Biochem Biophys Res Commun. 2003
PubMed ID: 12705885
Negative regulation of beta-catenin signaling by tyrosine phosphatase SHP-1 in intestinal epithelial cells.
Duchesne C, Charland S, Asselin C, Nahmias C, Rivard N
J Biol Chem. 2003
PubMed ID: 12571228
Actin tyrosine dephosphorylation by the Src homology 1-containing protein tyrosine phosphatase is essential for actin depolymerization after membrane IgM cross-linking.
Baba T, Fusaki N, Shinya N, Iwamatsu A, Hozumi N
J Immunol. 2003
PubMed ID: 12646642
Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient "viable motheaten" mice.
Lyons BL, Lynes MA, Burzenski L, Joliat MJ, Hadjout N, Shultz LD
Exp Hematol. 2003
PubMed ID: 12644021
Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor.
Davidson D, Bakinowski M, Thomas ML, Horejsi V, Veillette A
Mol Cell Biol. 2003
PubMed ID: 12612075
Crystal structure of human protein-tyrosine phosphatase SHP-1.
Yang J, Liu L, He D, Song X, Liang X, Zhao ZJ, Zhou GW
J Biol Chem. 2003
PubMed ID: 12482860
The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation.
Zhang Z, Shen K, Lu W, Cole PA
J Biol Chem. 2003
PubMed ID: 12468540
Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome.
Hanson EM, Dickensheets H, Qu CK, Donnelly RP, Keegan AD
J Biol Chem. 2003
PubMed ID: 12459556
Normal B-1 cell development but defective BCR signaling in Lck-/- mice.
Ulivieri C, Valensin S, Majolini MB, Matthews RJ, Baldari CT
Eur J Immunol. 2003
PubMed ID: 12645942
Abnormal splicing of SHP-1 protein tyrosine phosphatase in human T cells. Implications for lymphomagenesis.
Ma XZ, Jin T, Sakac D, Fahim S, Zhang X, Katsman Y, Bali M, Branch DR
Exp Hematol. 2003
PubMed ID: 12591278
src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation.
Kamata T, Yamashita M, Kimura M, Murata K, Inami M, Shimizu C, Sugaya K, Wang CR, Taniguchi M, Nakayama T
J Clin Invest. 2003
PubMed ID: 12511594
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling.
Paling NR, Welham MJ
Biochem J. 2002
PubMed ID: 12220225
Modulation of the ERG K+ current by the tyrosine phosphatase, SHP-1.
Cayabyab FS, Tsui FW, Schlichter LC
J Biol Chem. 2002
PubMed ID: 12361947
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Expression and subcellular distribution of the active form of c-Src tyrosine kinase in differentiating human endometrial stromal cells.
Yamamoto Y, Maruyama T, Sakai N, Sakurai R, Shimizu A, Hamatani T, Masuda H, Uchida H, Sabe H, Yoshimura Y
Mol Hum Reprod. 2002
PubMed ID: 12468645
Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas.
Oka T, Ouchida M, Koyama M, Ogama Y, Takada S, Nakatani Y, Tanaka T, Yoshino T, Hayashi K, Ohara N, Kondo E, Takahashi K, Tsuchiyama J, Tanimoto M, Shimizu K, Akagi T
Cancer Res. 2002
PubMed ID: 12438221
Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster.
Washington AV, Quigley L, McVicar DW
Blood. 2002
PubMed ID: 12393607
The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras.
Jimenez C, Hernandez C, Pimentel B, Carrera AC
J Biol Chem. 2002
PubMed ID: 12196526
SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells.
Eklund EA, Goldenberg I, Lu Y, Andrejic J, Kakar R
J Biol Chem. 2002
PubMed ID: 12145285
Gbeta gamma -independent constitutive association of Galpha s with SHP-1 and angiotensin II receptor AT2 is essential in AT2-mediated ITIM-independent activation of SHP-1.
Feng YH, Sun Y, Douglas JG
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12221292
Angiotensin II subtype 2 receptor activation inhibits insulin-induced phosphoinositide 3-kinase and Akt and induces apoptosis in PC12W cells.
Cui TX, Nakagami H, Nahmias C, Shiuchi T, Takeda-Matsubara Y, Li JM, Wu L, Iwai M, Horiuchi M
Mol Endocrinol. 2002
PubMed ID: 12198247
SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.
Kant AM, De P, Peng X, Yi T, Rawlings DJ, Kim JS, Durden DL
Blood. 2002
PubMed ID: 12176909
Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1.
Caselli A, Mazzinghi B, Camici G, Manao G, Ramponi G
Biochem Biophys Res Commun. 2002
PubMed ID: 12176037
Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1.
Kitzig F, Martinez-Barriocanal A, López-Botet M, Sayós J
Biochem Biophys Res Commun. 2002
PubMed ID: 12163025
SHP-1 expression in peripheral T cells from patients with Sezary syndrome and in the T cell line HUT-78: implications in JAK3-mediated signaling.
León F, Cespón C, Franco A, Lombardía M, Roldán E, Escribano L, Harto A, González-Porqué P, Roy G
Leukemia. 2002
PubMed ID: 12145687
Engagement of ILT2/CD85j in Sézary syndrome cells inhibits their CD3/TCR signaling.
Nikolova M, Musette P, Bagot M, Boumsell L, Bensussan A
Blood. 2002
PubMed ID: 12130517
Src homology region 2 domain-containing phosphatase 1 positively regulates B cell receptor-induced apoptosis by modulating association of B cell linker protein with Nck and activation of c-Jun NH2-terminal kinase.
Mizuno K, Tagawa Y, Mitomo K, Watanabe N, Katagiri T, Ogimoto M, Yakura H
J Immunol. 2002
PubMed ID: 12097380
Cloning and characterization of human Siglec-11. A recently evolved signaling that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.
Angata T, Kerr SC, Greaves DR, Varki NM, Crocker PR, Varki A
J Biol Chem. 2002
PubMed ID: 11986327
SPAP2, an Ig family receptor containing both ITIMs and ITAMs.
Xu MJ, Zhao R, Cao H, Zhao ZJ
Biochem Biophys Res Commun. 2002
PubMed ID: 12051764
Expression of the tyrosine phosphatase SRC homology 2 domain-containing protein tyrosine phosphatase 1 determines T cell activation threshold and severity of experimental autoimmune encephalomyelitis.
Deng C, Minguela A, Hussain RZ, Lovett-Racke AE, Radu C, Ward ES, Racke MK
J Immunol. 2002
PubMed ID: 11970996
Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement.
Saci A, Liu WQ, Vidal M, Garbay C, Rendu F, Bachelot-Loza C
Biochem J. 2002
PubMed ID: 11964172
Cutting edge: differential segregation of the SRC homology 2-containing protein tyrosine phosphatase-1 within the early NK cell immune synapse distinguishes noncytolytic from cytolytic interactions.
Vyas YM, Maniar H, Dupont B
J Immunol. 2002
PubMed ID: 11907066
Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration.
Yu WM, Hawley TS, Hawley RG, Qu CK
Blood. 2002
PubMed ID: 11895767
T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7.
Christianson SW, Greiner DL, Deluca D, Leif J, Phillips NE, Hayes SM, Hayashi S, Joliat MJ, Lyons BL, Shultz LD
J Autoimmun. 2002
PubMed ID: 11908944
Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' mice.
Joliat MJ, Lang PA, Lyons BL, Burzenski L, Lynes MA, Yi T, Sundberg JP, Shultz LD
J Autoimmun. 2002
PubMed ID: 11908943
Molecular interactions of SHP1 and SHP2 in IL-3-signalling.
Wheadon H, Paling NR, Welham MJ
Cell Signal. 2002
PubMed ID: 11812650
Molecular assembly of CD46 with CD9, alpha3-beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF.
Kurita-Taniguchi M, Hazeki K, Murabayashi N, Fukui A, Tsuji S, Matsumoto M, Toyoshima K, Seya T
Mol Immunol. 2002
PubMed ID: 11858824
Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner.
Lee YK, Moore DD
J Biol Chem. 2002
PubMed ID: 11668176
A bipartite NLS at the SHP-1 C-terminus mediates cytokine-induced SHP-1 nuclear localization in cell growth control.
Yang W, Tabrizi M, Yi T
Blood Cells Mol Dis. 2002
PubMed ID: 11987243
Lyn/CD22/SHP-1 and their importance in autoimmunity.
Blasioli J, Goodnow CC
Curr Dir Autoimmun. 2002
PubMed ID: 11826756
Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils.
Daigle I, Yousefi S, Colonna M, Green DR, Simon HU
Nat Med. 2002
PubMed ID: 11786908
Lack of the protein tyrosine phosphatase SHP-1 results in decreased numbers of glia within the motheaten (me/me) mouse brain.
Wishcamper CA, Coffin JD, Lurie DI
J Comp Neurol. 2001
PubMed ID: 11745639
Negative regulation of the SHPTP1 protein tyrosine phosphatase by protein kinase C delta in response to DNA damage.
Yoshida K, Kufe D
Mol Pharmacol. 2001
PubMed ID: 11723252
Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation.
Kashiwada M, Giallourakis CC, Pan PY, Rothman PB
J Immunol. 2001
PubMed ID: 11714803
CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1.
Otipoby KL, Draves KE, Clark EA
J Biol Chem. 2001
PubMed ID: 11551923
G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2.
de Vet EC, Aguado B, Campbell RD
J Biol Chem. 2001
PubMed ID: 11544253
Role of host phosphotyrosine phosphatase SHP-1 in the development of murine leishmaniasis.
Forget G, Siminovitch KA, Brochu S, Rivest S, Radzioch D, Olivier M
Eur J Immunol. 2001
PubMed ID: 11745335
Neuronal nitric oxide synthase: a substrate for SHP-1 involved in sst2 somatostatin receptor growth inhibitory signaling.
Lopez F, Ferjoux G, Cordelier P, Saint-Laurent N, Estève JP, Vaysse N, Buscail L, Susini C
FASEB J. 2001
PubMed ID: 11511520
NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease.
Bottino C, Falco M, Parolini S, Marcenaro E, Augugliaro R, Sivori S, Landi E, Biassoni R, Notarangelo LD, Moretta L, Moretta A
J Exp Med. 2001
PubMed ID: 11489943
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase.
Cuevas BD, Lu Y, Mao M, Zhang J, LaPushin R, Siminovitch K, Mills GB
J Biol Chem. 2001
PubMed ID: 11337495
SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates.
Adachi T, Wienands J, Wakabayashi C, Yakura H, Reth M, Tsubata T
J Biol Chem. 2001
PubMed ID: 11356834
Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.
Lewis J, Eiben LJ, Nelson DL, Cohen JI, Nichols KE, Ochs HD, Notarangelo LD, Duckett CS
Clin Immunol. 2001
PubMed ID: 11414741
Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs.
Yu Z, Lai CM, Maoui M, Banville D, Shen SH
J Biol Chem. 2001
PubMed ID: 11328818
Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase.
Chiang GG, Sefton BM
J Biol Chem. 2001
PubMed ID: 11294838
Expression of genes involved in mammalian meiosis during the transition from egg to embryo.
Hwang SY, Oh B, Knowles BB, Solter D, Lee JS
Mol Reprod Dev. 2001
PubMed ID: 11389549
Molecular cloning of MIS, a myeloid inhibitory siglec, that binds protein-tyrosine phosphatases SHP-1 and SHP-2.
Ulyanova T, Shah DD, Thomas ML
J Biol Chem. 2001
PubMed ID: 11278955
CD47-signal regulatory protein alpha (SIRPalpha) regulates Fcgamma and complement receptor-mediated phagocytosis.
Oldenborg PA, Gresham HD, Lindberg FP
J Exp Med. 2001
PubMed ID: 11283158
The sequence of the human genome.
Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigó R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X
Science. 2001
PubMed ID: 11181995
Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants.
Huang X, Yuan Z, Chen G, Zhang M, Zhang W, Yu Y, Cao X
Biochem Biophys Res Commun. 2001
PubMed ID: 11178971
Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development.
Qu CK, Nguyen S, Chen J, Feng GS
Blood. 2001
PubMed ID: 11159516
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells.
Sathish JG, Johnson KG, Fuller KJ, LeRoy FG, Meyaard L, Sims MJ, Matthews RJ
J Immunol. 2001
PubMed ID: 11160222
A novel role for protein tyrosine phosphatase shp1 in controlling glial activation in the normal and injured nervous system.
Horvat A, Schwaiger F, Hager G, Brocker F, Streif R, Knyazev P, Ullrich A, Kreutzberg GW
J Neurosci. 2001
PubMed ID: 11157073
Molecular cloning and characterization of SPAP1, an inhibitory receptor.
Xu MJ, Zhao R, Zhao ZJ
Biochem Biophys Res Commun. 2001
PubMed ID: 11162587
Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
Keilhack H, Müller M, Böhmer SA, Frank C, Weidner KM, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Günther B, Müller T, Birchmeier C, Böhmer FD
J Cell Biol. 2001
PubMed ID: 11266449
The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells.
Somani AK, Yuen K, Xu F, Zhang J, Branch DR, Siminovitch KA
J Biol Chem. 2001
PubMed ID: 11042209
Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to gamma-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant mice.
Hsu HC, Shultz LD, Su X, Shi J, Yang PA, Relyea MJ, Zhang HG, Mountz JD
J Immunol. 2001
PubMed ID: 11145649
Somatostatin modulates G-CSF-induced but not interleukin-3-induced proliferative responses in myeloid 32D cells via activation of somatostatin receptor subtype 2.
Oomen SP, Ward AC, Hofland LJ, Lamberts SW, Löwenberg B, Touw IP
Hematol J. 2001
PubMed ID: 11920268
Deficiency of Src homology 2-containing phosphatase 1 results in abnormalities in murine neutrophil function: studies in motheaten mice.
Kruger J, Butler JR, Cherapanov V, Dong Q, Ginzberg H, Govindarajan A, Grinstein S, Siminovitch KA, Downey GP
J Immunol. 2000
PubMed ID: 11067945
Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling.
Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T, Matsumoto M, Yoshida K, Yakura H, Pan C, Parnes JR, Kikutani H
Immunity. 2000
PubMed ID: 11114375
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
BCR/ABL inhibition by an escort/phosphatase fusion protein.
Lim YM, Wong S, Lau G, Witte ON, Colicelli J
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11027300
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia.
Beghini A, Ripamonti CB, Peterlongo P, Roversi G, Cairoli R, Morra E, Larizza L
Hum Mol Genet. 2000
PubMed ID: 11001933
The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin.
Keilhack H, Hellman U, van Hengel J, van Roy F, Godovac-Zimmermann J, Böhmer FD
J Biol Chem. 2000
PubMed ID: 10835420
Subcellular localization of intracellular protein tyrosine phosphatases in T cells.
Gjörloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M, Oh P, Williams S, Schnitzer J, Mustelin T
Eur J Immunol. 2000
PubMed ID: 10940933
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Src homology region 2 (SH2) domain-containing phosphatase-1 dephosphorylates B cell linker protein/SH2 domain leukocyte protein of 65 kDa and selectively regulates c-Jun NH2-terminal kinase activation in B cells.
Mizuno K, Tagawa Y, Mitomo K, Arimura Y, Hatano N, Katagiri T, Ogimoto M, Yakura H
J Immunol. 2000
PubMed ID: 10903736
Impaired natural killing of MHC class I-deficient targets by NK cells expressing a catalytically inactive form of SHP-1.
Lowin-Kropf B, Kunz B, Beermann F, Held W
J Immunol. 2000
PubMed ID: 10903732
FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells.
Fournier N, Chalus L, Durand I, Garcia E, Pin JJ, Churakova T, Patel S, Zlot C, Gorman D, Zurawski S, Abrams J, Bates EE, Garrone P
J Immunol. 2000
PubMed ID: 10903717
Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells.
Xu M, Zhao R, Zhao ZJ
J Biol Chem. 2000
PubMed ID: 10764762
Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk.
Ganju RK, Brubaker SA, Chernock RD, Avraham S, Groopman JE
J Biol Chem. 2000
PubMed ID: 10747947
Differential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathways.
Bartoe JL, Nathanson NM
J Neurochem. 2000
PubMed ID: 10800945
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.
Brdicka T, Pavlistová D, Leo A, Bruyns E, Korínek V, Angelisová P, Scherer J, Shevchenko A, Hilgert I, Cerný J, Drbal K, Kuramitsu Y, Kornacker B, Horejsí V, Schraven B
J Exp Med. 2000
PubMed ID: 10790433
PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta.
Mousseau DD, Banville D, L'Abbé D, Bouchard P, Shen SH
J Biol Chem. 2000
PubMed ID: 10660620
Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1.
Yang J, Cheng Z, Niu T, Liang X, Zhao ZJ, Zhou GW
J Biol Chem. 2000
PubMed ID: 10660565
SH2-Containing protein tyrosine phosphatase-1 (SHP-1) association with Jak2 in UT-7/Epo cells.
Wu DW, Stark KC, Dunnington D, Dillon SB, Yi T, Jones C, Pelus LM
Blood Cells Mol Dis. 2000
PubMed ID: 10772872
Positive regulation of c-Jun N-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cells.
Xie ZH, Zhang J, Siraganian RP
J Immunol. 2000
PubMed ID: 10640770
Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation.
Yu CL, Jin YJ, Burakoff SJ
J Biol Chem. 2000
PubMed ID: 10617656
Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B.
Ho LH, Uehara T, Chen CC, Kubagawa H, Cooper MD
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10611342
SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages.
Berg KL, Siminovitch KA, Stanley ER
J Biol Chem. 1999
PubMed ID: 10585470
Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage.
Yoshida K, Kharbanda S, Kufe D
J Biol Chem. 1999
PubMed ID: 10574931
The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds.
Carter JD, Neel BG, Lorenz U
Int Immunol. 1999
PubMed ID: 10590266
Negative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase SHPTP1.
Kumar S, Avraham S, Bharti A, Goyal J, Pandey P, Kharbanda S
J Biol Chem. 1999
PubMed ID: 10521452
Regulation of acidification and apoptosis by SHP-1 and Bcl-2.
Thangaraju M, Sharma K, Leber B, Andrews DW, Shen SH, Srikant CB
J Biol Chem. 1999
PubMed ID: 10506221
SHP-1 variant proteins are absent in motheaten mice despite presence of splice variant transcripts with open reading frames.
Martin A, Tsui HW, Tsui FW
Mol Immunol. 1999
PubMed ID: 10698306
The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway.
Vila-Coro AJ, Rodríguez-Frade JM, Martín De Ana A, Moreno-Ortíz MC, Martínez-A C, Mellado M
FASEB J. 1999
PubMed ID: 10506573
Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activity.
Jin YJ, Yu CL, Burakoff SJ
J Biol Chem. 1999
PubMed ID: 10497187
SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity.
Cuevas B, Lu Y, Watt S, Kumar R, Zhang J, Siminovitch KA, Mills GB
J Biol Chem. 1999
PubMed ID: 10488096
Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection.
Zhang J, Somani AK, Yuen D, Yang Y, Love PE, Siminovitch KA
J Immunol. 1999
PubMed ID: 10477564
Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses.
Kim CH, Qu CK, Hangoc G, Cooper S, Anzai N, Feng GS, Broxmeyer HE
J Exp Med. 1999
PubMed ID: 10477552
The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me(v)/me(v) mutant mice.
Aoki K, Didomenico E, Sims NA, Mukhopadhyay K, Neff L, Houghton A, Amling M, Levy JB, Horne WC, Baron R
Bone. 1999
PubMed ID: 10495129
Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1.
Brockdorff J, Williams S, Couture C, Mustelin T
Eur J Immunol. 1999
PubMed ID: 10458769
H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1.
Daws MR, Eriksson M, Oberg L, Ullén A, Sentman CL
Immunology. 1999
PubMed ID: 10457220
Murine SHP-1 splice variants with altered Src homology 2 (SH2) domains. Implications for the SH2-mediated intramolecular regulation of SHP-1.
Martin A, Tsui HW, Shulman MJ, Isenman D, Tsui FW
J Biol Chem. 1999
PubMed ID: 10419485
Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density.
Umeda S, Beamer WG, Takagi K, Naito M, Hayashi S, Yonemitsu H, Yi T, Shultz LD
Am J Pathol. 1999
PubMed ID: 10393854
Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells.
Fernandes MJ, Finnegan AA, Siracusa LD, Brenner C, Iscove NN, Calabretta B
Cancer Res. 1999
PubMed ID: 10363996
The Src-homology domain 2-bearing protein tyrosine phosphatase-1 inhibits antigen receptor-induced apoptosis of activated peripheral T cells.
Zhang J, Somani AK, Watt S, Mills GB, Siminovitch KA
J Immunol. 1999
PubMed ID: 10352248
Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function.
Carlyle JR, Martin A, Mehra A, Attisano L, Tsui FW, Zúñiga-Pflücker JC
J Immunol. 1999
PubMed ID: 10229828
CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein tyrosine phosphatase SHP-1.
Greer SF, Justement LB
J Immunol. 1999
PubMed ID: 10228003
Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31.
Pumphrey NJ, Taylor V, Freeman S, Douglas MR, Bradfield PF, Young SP, Lord JM, Wakelam MJ, Bird IN, Salmon M, Buckley CD
FEBS Lett. 1999
PubMed ID: 10350061
The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2.
Taylor VC, Buckley CD, Douglas M, Cody AJ, Simmons DL, Freeman SD
J Biol Chem. 1999
PubMed ID: 10206955
TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1.
Johnson KG, LeRoy FG, Borysiewicz LK, Matthews RJ
J Immunol. 1999
PubMed ID: 10201897
CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1.
Perez-Villar JJ, Whitney GS, Bowen MA, Hewgill DH, Aruffo AA, Kanner SB
Mol Cell Biol. 1999
PubMed ID: 10082557
Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation.
Dustin LB, Plas DR, Wong J, Hu YT, Soto C, Chan AC, Thomas ML
J Immunol. 1999
PubMed ID: 10072516
Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B.
Wang LL, Blasioli J, Plas DR, Thomas ML, Yokoyama WM
J Immunol. 1999
PubMed ID: 9973385
Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22.
Blasioli J, Paust S, Thomas ML
J Biol Chem. 1999
PubMed ID: 9890995
The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells.
Huber M, Izzi L, Grondin P, Houde C, Kunath T, Veillette A, Beauchemin N
J Biol Chem. 1999
PubMed ID: 9867848
Aberrant expression of the NF-kappaB and IkappaB proteins in B cells from viable motheaten mice.
Khaled AR, Butfiloski EJ, Villas B, Sobel ES, Schiffenbauer J
Autoimmunity. 1999
PubMed ID: 10435725
Genetic analysis of B cell antigen receptor signaling.
Kurosaki T
Annu Rev Immunol. 1999
PubMed ID: 10358768
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
The major SHP-1-binding, tyrosine-phosphorylated protein in macrophages is a member of the KIR/LIR family and an SHP-1 substrate.
Berg KL, Carlberg K, Rohrschneider LR, Siminovitch KA, Stanley ER
Oncogene. 1998
PubMed ID: 9824165
Tyrosine unphosphorylated platelet SHP-1 is a substrate for calpain.
Falet H, Pain S, Rendu F
Biochem Biophys Res Commun. 1998
PubMed ID: 9813145
The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes.
Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L
Eur J Immunol. 1998
PubMed ID: 9842885
SHP-1 deficiency in B-lineage cells is associated with heightened lyn protein expression and increased lyn kinase activity.
Yang W, Mckenna SD, Jiao H, Tabrizi M, Lynes MA, Shultz LD, Yi T
Exp Hematol. 1998
PubMed ID: 9808051
Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates.
Hua CT, Gamble JR, Vadas MA, Jackson DE
J Biol Chem. 1998
PubMed ID: 9774457
Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1.
Yang J, Liang X, Niu T, Meng W, Zhao Z, Zhou GW
J Biol Chem. 1998
PubMed ID: 9774441
SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors.
Binstadt BA, Billadeau DD, Jevremović D, Williams BL, Fang N, Yi T, Koretzky GA, Abraham RT, Leibson PJ
J Biol Chem. 1998
PubMed ID: 9765283
Regulation of Bcr-Abl-induced SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase.
Liedtke M, Pandey P, Kumar S, Kharbanda S, Kufe D
Oncogene. 1998
PubMed ID: 9788431
Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signaling.
Keilhack H, Tenev T, Nyakatura E, Godovac-Zimmermann J, Nielsen L, Seedorf K, Böhmer FD
J Biol Chem. 1998
PubMed ID: 9733788
The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages.
Roach TI, Slater SE, White LS, Zhang X, Majerus PW, Brown EJ, Thomas ML
Curr Biol. 1998
PubMed ID: 9740804
The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1.
Wu Y, Nadler MJ, Brennan LA, Gish GD, Timms JF, Fusaki N, Jongstra-Bilen J, Tada N, Pawson T, Wither J, Neel BG, Hozumi N
Curr Biol. 1998
PubMed ID: 9740800
High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages.
Veillette A, Thibaudeau E, Latour S
J Biol Chem. 1998
PubMed ID: 9712903
Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages.
Timms JF, Carlberg K, Gu H, Chen H, Kamatkar S, Nadler MJ, Rohrschneider LR, Neel BG
Mol Cell Biol. 1998
PubMed ID: 9632768
Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins.
Moutoussamy S, Renaudie F, Lago F, Kelly PA, Finidori J
J Biol Chem. 1998
PubMed ID: 9632636
The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation.
Adachi T, Flaswinkel H, Yakura H, Reth M, Tsubata T
J Immunol. 1998
PubMed ID: 9590210
SHP-1 phosphatase C-terminus interacts with novel substrates p32/p30 during erythropoietin and interleukin-3 mitogenic responses.
Yang W, Tabrizi M, Berrada K, Yi T
Blood. 1998
PubMed ID: 9573011
Functional consequences of the SHP-1 defect in motheaten viable mice: role of NF-kappa B.
Khaled AR, Butfiloski EJ, Sobel ES, Schiffenbauer J
Cell Immunol. 1998
PubMed ID: 9636682
Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.
Cornall RJ, Cyster JG, Hibbs ML, Dunn AR, Otipoby KL, Clark EA, Goodnow CC
Immunity. 1998
PubMed ID: 9586639
Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules.
Colonna M, Samaridis J, Cella M, Angman L, Allen RL, O'Callaghan CA, Dunbar R, Ogg GS, Cerundolo V, Rolink A
J Immunol. 1998
PubMed ID: 9531263
SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain.
Kozlowski M, Larose L, Lee F, Le DM, Rottapel R, Siminovitch KA
Mol Cell Biol. 1998
PubMed ID: 9528781
Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells.
Migone TS, Cacalano NA, Taylor N, Yi T, Waldmann TA, Johnston JA
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9520455
sst2 somatostatin receptor mediates negative regulation of insulin receptor signaling through the tyrosine phosphatase SHP-1.
Bousquet C, Delesque N, Lopez F, Saint-Laurent N, Estève JP, Bedecs K, Buscail L, Vaysse N, Susini C
J Biol Chem. 1998
PubMed ID: 9507021
The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1.
Bléry M, Kubagawa H, Chen CC, Vély F, Cooper MD, Vivier E
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9482905
Aberrant regulation of bone trace elements in motheaten and osteopetrosis mutant mice.
Yamada G, Nakamura S, Haraguchi R, Sakai M, Suzuki K, Miyado K, Hasuwa H, Ogino Y, Minami T, Tohno Y, Blum M, Shultz LD
Cell Mol Biol (Noisy-le-grand). 1998
PubMed ID: 9593582
Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene.
Kuroiwa A, Yamashita Y, Inui M, Yuasa T, Ono M, Nagabukuro A, Matsuda Y, Takai T
J Biol Chem. 1998
PubMed ID: 9422771
Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases.
Le Dréan E, Vély F, Olcese L, Cambiaggi A, Guia S, Krystal G, Gervois N, Moretta A, Jotereau F, Vivier E
Eur J Immunol. 1998
PubMed ID: 9485206
Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6.
Ansari-Lari MA, Oeltjen JC, Schwartz S, Zhang Z, Muzny DM, Lu J, Gorrell JH, Chinault AC, Belmont JW, Miller W, Gibbs RA
Genome Res. 1998
PubMed ID: 9445485
The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells.
Kroll J, Waltenberger J
J Biol Chem. 1997
PubMed ID: 9405464
Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor.
Kimura T, Zhang J, Sagawa K, Sakaguchi K, Appella E, Siraganian RP
J Immunol. 1997
PubMed ID: 9379041
Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.
Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J, Beier DR
Genome Res. 1997
PubMed ID: 9371744
Role of tumor necrosis factor-alpha in the spontaneous development of pulmonary fibrosis in viable motheaten mutant mice.
Thrall RS, Vogel SN, Evans R, Shultz LD
Am J Pathol. 1997
PubMed ID: 9358756
Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
Gene. 1997
PubMed ID: 9373149
Co-localization of Fyn with CD3 complex, CD45 or CD28 depends on different mechanisms.
zur Hausen JD, Burn P, Amrein KE
Eur J Immunol. 1997
PubMed ID: 9368621
The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling.
Lopez F, Estève JP, Buscail L, Delesque N, Saint-Laurent N, Théveniau M, Nahmias C, Vaysse N, Susini C
J Biol Chem. 1997
PubMed ID: 9305905
DNA-binding antibodies from viable motheaten mutant mice: implications for B cell tolerance.
Westhoff CM, Whittier A, Kathol S, McHugh J, Zajicek C, Shultz LD, Wylie DE
J Immunol. 1997
PubMed ID: 9300728
Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase.
Somani AK, Bignon JS, Mills GB, Siminovitch KA, Branch DR
J Biol Chem. 1997
PubMed ID: 9261115
The motheaten mutation rescues B cell signaling and development in CD45-deficient mice.
Pani G, Siminovitch KA, Paige CJ
J Exp Med. 1997
PubMed ID: 9254656
Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival.
Pazdrak K, Adachi T, Alam R
J Exp Med. 1997
PubMed ID: 9254654
Abnormal development and differentiation of macrophages and dendritic cells in viable motheaten mutant mice deficient in haematopoietic cell phosphatase.
Nakayama K, Takahashi K, Shultz LD, Miyakawa K, Tomita K
Int J Exp Pathol. 1997
PubMed ID: 9505936
LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes.
Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH
Immunity. 1997
PubMed ID: 9285412
A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules.
Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML
Immunity. 1997
PubMed ID: 9285411
Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency.
Shultz LD, Rajan TV, Greiner DL
Trends Biotechnol. 1997
PubMed ID: 9263478
Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling.
Ono M, Okada H, Bolland S, Yanagi S, Kurosaki T, Ravetch JV
Cell. 1997
PubMed ID: 9244303
Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase.
Ram PA, Waxman DJ
J Biol Chem. 1997
PubMed ID: 9211920
Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transduction.
Jiao H, Yang W, Berrada K, Tabrizi M, Shultz L, Yi T
Exp Hematol. 1997
PubMed ID: 9216734
SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates.
Bone H, Dechert U, Jirik F, Schrader JW, Welham MJ
J Biol Chem. 1997
PubMed ID: 9162089
A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing.
Cella M, Döhring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M
J Exp Med. 1997
PubMed ID: 9151699
A novel phosphotyrosine motif with a critical amino acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1.
Burshtyn DN, Yang W, Yi T, Long EO
J Biol Chem. 1997
PubMed ID: 9148918
Restricted CDR3 length of the heavy chain is characteristic of six randomly isolated disease-associated VH J558+ IgM autoantibodies in lupus prone motheaten mice.
Lipsanen V, Walter B, Emara M, Siminovitch K, Lam J, Kaushik A
Int Immunol. 1997
PubMed ID: 9184911
Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling.
Fusaki N, Iwamatsu A, Iwashima M, Fujisawa J
J Biol Chem. 1997
PubMed ID: 9045636
Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.
Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA
Genome Res. 1997
PubMed ID: 9074930
Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase.
Nakamura MC, Niemi EC, Fisher MJ, Shultz LD, Seaman WE, Ryan JC
J Exp Med. 1997
PubMed ID: 9034146
Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal localization of genes.
Yamao T, Matozaki T, Amano K, Matsuda Y, Takahashi N, Ochi F, Fujioka Y, Kasuga M
Biochem Biophys Res Commun. 1997
PubMed ID: 9070220
A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor.
Abramovich C, Yakobson B, Chebath J, Revel M
EMBO J. 1997
PubMed ID: 9029147
A comparative analysis of the murine thymic microenvironment in normal, autoimmune, and immunodeficiency states.
Takeoka Y, Chen SY, Boyd RL, Tsuneyama K, Taguchi N, Morita S, Yago H, Suehiro S, Ansari AA, Shultz LD, Gershwin ME
Dev Immunol. 1997
PubMed ID: 9587708
Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1.
Piao X, Paulson R, van der Geer P, Pawson T, Bernstein A
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8962111
Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1.
Jiao H, Berrada K, Yang W, Tabrizi M, Platanias LC, Yi T
Mol Cell Biol. 1996
PubMed ID: 8943354
A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion.
Fujioka Y, Matozaki T, Noguchi T, Iwamatsu A, Yamao T, Takahashi N, Tsuda M, Takada T, Kasuga M
Mol Cell Biol. 1996
PubMed ID: 8943344
Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow.
Huang K, Sommers CL, Grinberg A, Kozak CA, Love PE
Oncogene. 1996
PubMed ID: 8875997
Genes for murine Y1 and Y3 Ro RNAs have class 3 RNA polymerase III promoter structures and are unlinked on mouse chromosome 6.
Farris AD, Gross JK, Hanas JS, Harley JB
Gene. 1996
PubMed ID: 8863726
Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness.
Lorenz U, Ravichandran KS, Burakoff SJ, Neel BG
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8790380
Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase.
Pani G, Fischer KD, Mlinaric-Rascan I, Siminovitch KA
J Exp Med. 1996
PubMed ID: 9064344
Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1.
Lorenz U, Bergemann AD, Steinberg HN, Flanagan JG, Li X, Galli SJ, Neel BG
J Exp Med. 1996
PubMed ID: 9064328
Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase.
Uddin S, Gardziola C, Dangat A, Yi T, Platanias LC
Biochem Biophys Res Commun. 1996
PubMed ID: 8780698
Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells.
Mizuno K, Katagiri T, Hasegawa K, Ogimoto M, Yakura H
J Exp Med. 1996
PubMed ID: 8760799
The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.
Kharbanda S, Bharti A, Pei D, Wang J, Pandey P, Ren R, Weichselbaum R, Walsh CT, Kufe D
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8692915
Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1.
Paulson RF, Vesely S, Siminovitch KA, Bernstein A
Nat Genet. 1996
PubMed ID: 8673130
Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect.
Su X, Zhou T, Yang PA, Wang Z, Mountz JD
J Immunol. 1996
PubMed ID: 8666788
Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain.
Stover DR, Furet P, Lydon NB
J Biol Chem. 1996
PubMed ID: 8647855
Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling.
Plas DR, Johnson R, Pingel JT, Matthews RJ, Dalton M, Roy G, Chan AC, Thomas ML
Science. 1996
PubMed ID: 8638162
Mouse chromosomal location of three epithelial sodium channel subunit genes and an apical sodium chloride cotransporter gene.
Pathak BG, Shaughnessy JD, Meneton P, Greeb J, Shull GE, Jenkins NA, Copeland NG
Genomics. 1996
PubMed ID: 8617496
Cloning and characterization of a novel transcriptional repressor of the nicotinic acetylcholine receptor delta-subunit gene.
Sapru MK, Gao JP, Walke W, Burmeister M, Goldman D
J Biol Chem. 1996
PubMed ID: 8636158
The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells.
Kon-Kozlowski M, Pani G, Pawson T, Siminovitch KA
J Biol Chem. 1996
PubMed ID: 8632004
CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation.
Law CL, Sidorenko SP, Chandran KA, Zhao Z, Shen SH, Fischer EH, Clark EA
J Exp Med. 1996
PubMed ID: 8627166
Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor.
Burshtyn DN, Scharenberg AM, Wagtmann N, Rajagopalan S, Berrada K, Yi T, Kinet JP, Long EO
Immunity. 1996
PubMed ID: 8574854
Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells.
Mu SX, Xia M, Elliott G, Bogenberger J, Swift S, Bennett L, Lappinga DL, Hecht R, Lee R, Saris CJ
Blood. 1995
PubMed ID: 8541543
Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1.
David M, Chen HE, Goelz S, Larner AC, Neel BG
Mol Cell Biol. 1995
PubMed ID: 8524272
Association of SH2 domain protein tyrosine phosphatases with the epidermal growth factor receptor in human tumor cells. Phosphatidic acid activates receptor dephosphorylation by PTP1C.
Tomic S, Greiser U, Lammers R, Kharitonenkov A, Imyanitov E, Ullrich A, Böhmer FD
J Biol Chem. 1995
PubMed ID: 7673163
Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase.
Yetter A, Uddin S, Krolewski JJ, Jiao H, Yi T, Platanias LC
J Biol Chem. 1995
PubMed ID: 7629131
A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP.
Doody GM, Justement LB, Delibrias CC, Matthews RJ, Lin J, Thomas ML, Fearon DT
Science. 1995
PubMed ID: 7618087
Alternative mRNA splicing and differential promoter utilization determine tissue-specific expression of the apolipoprotein B mRNA-editing protein (Apobec1) gene in mice. Structure and evolution of Apobec1 and related nucleoside/nucleotide deaminases.
Nakamuta M, Oka K, Krushkal J, Kobayashi K, Yamamoto M, Li WH, Chan L
J Biol Chem. 1995
PubMed ID: 7768898
Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein.
Li RY, Gaits F, Ragab A, Ragab-Thomas JM, Chap H
EMBO J. 1995
PubMed ID: 7781604
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.
Pani G, Kozlowski M, Cambier JC, Mills GB, Siminovitch KA
J Exp Med. 1995
PubMed ID: 7539038
Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternate promoter usage and exon skipping generate multiple transcripts.
Banville D, Stocco R, Shen SH
Genomics. 1995
PubMed ID: 7665165
Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1.
D'Ambrosio D, Hippen KL, Minskoff SA, Mellman I, Pani G, Siminovitch KA, Cambier JC
Science. 1995
PubMed ID: 7716523
Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis.
Su X, Zhou T, Wang Z, Yang P, Jope RS, Mountz JD
Immunity. 1995
PubMed ID: 7536621
Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals.
Klingmüller U, Lorenz U, Cantley LC, Neel BG, Lodish HF
Cell. 1995
PubMed ID: 7889566
Skewed VH and V kappa gene family expression and pairing occurs among B lymphocytes in autoimmune motheaten mice.
Saitoh Y, Kelsoe G, Bona C, Kaushik A
Autoimmunity. 1995
PubMed ID: 8822276
Interactions of the scid or beige mutations with the viable motheaten mutation.
Dominique V, Francis L
Autoimmunity. 1995
PubMed ID: 8781712
Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection.
Cyster JG, Goodnow CC
Immunity. 1995
PubMed ID: 7600299
Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro.
Arnold SF, Obourn JD, Jaffe H, Notides AC
Mol Endocrinol. 1995
PubMed ID: 7539106
Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites.
Yi T, Zhang J, Miura O, Ihle JN
Blood. 1995
PubMed ID: 7528577
Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function.
Bignon JS, Siminovitch KA
Clin Immunol Immunopathol. 1994
PubMed ID: 7923924
Increased expression of the stefin A cysteine proteinase inhibitor occurs in the myelomonocytic cell-infiltrated tissues of autoimmune motheaten mice.
Mlinaric-Rascan I, Asa SL, Siminovitch KA
Am J Pathol. 1994
PubMed ID: 7943179
The viable motheaten (mev) mouse--a new model for arthritis.
Kovarik J, Kuntz L, Ryffel B, Borel JF
J Autoimmun. 1994
PubMed ID: 7840851
Expression of protein tyrosine phosphatase genes in the developing brain of mouse and rat.
Tagawa M, Shirasawa T, Fujimura S, Sakiyama S
Biochem Mol Biol Int. 1994
PubMed ID: 7804149
Phosphorylation and identification of a major tyrosine phosphorylation site in protein tyrosine phosphatase 1C.
Bouchard P, Zhao Z, Banville D, Dumas F, Fischer EH, Shen SH
J Biol Chem. 1994
PubMed ID: 7518460
Insulin stimulates the phosphorylation of Tyr538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains.
Uchida T, Matozaki T, Noguchi T, Yamao T, Horita K, Suzuki T, Fujioka Y, Sakamoto C, Kasuga M
J Biol Chem. 1994
PubMed ID: 7512963
Molecular basis of the motheaten phenotype.
Tsui FW, Tsui HW
Immunol Rev. 1994
PubMed ID: 8070815
Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells.
Lorenz U, Ravichandran KS, Pei D, Walsh CT, Burakoff SJ, Neel BG
Mol Cell Biol. 1994
PubMed ID: 8114715
Localization of prothymocytes from wild-type and viable motheaten mice following intravenous injection into irradiated adoptive recipients.
Hayes SM, Shultz LD, Greiner DL
Cell Immunol. 1994
PubMed ID: 8118868
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
PubMed ID: 8125298
Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis.
Yi T, Mui AL, Krystal G, Ihle JN
Mol Cell Biol. 1993
PubMed ID: 8246974
Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.
Kozlowski M, Mlinaric-Rascan I, Feng GS, Shen R, Pawson T, Siminovitch KA
J Exp Med. 1993
PubMed ID: 8245788
Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.
Shultz LD, Schweitzer PA, Rajan TV, Yi T, Ihle JN, Matthews RJ, Thomas ML, Beier DR
Cell. 1993
PubMed ID: 8324828
Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene.
Tsui HW, Siminovitch KA, de Souza L, Tsui FW
Nat Genet. 1993
PubMed ID: 8348149
Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand.
Yi T, Ihle JN
Mol Cell Biol. 1993
PubMed ID: 7684496
Modulation of adoptively transferred viable motheaten pathology in sublethally irradiated normal recipient mice by normal hematopoietic cells.
Kuntz L, Jachez B, Roman D, Loor F
Cell Immunol. 1993
PubMed ID: 8093859
Protein tyrosine phosphatase-1C is rapidly phosphorylated in tyrosine in macrophages in response to colony stimulating factor-1.
Yeung YG, Berg KL, Pixley FJ, Angeletti RH, Stanley ER
J Biol Chem. 1992
PubMed ID: 1385421
Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6.
Yi T, Gilbert DJ, Jenkins NA, Copeland NG, Ihle JN
Genomics. 1992
PubMed ID: 1427910
Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6).
Plutzky J, Neel BG, Rosenberg RD, Eddy RL, Byers MG, Jani-Sait S, Shows TB
Genomics. 1992
PubMed ID: 1639416
Effect of treatment on pulmonary functions in chronic severe anaemia.
Ghalaut PS, Mahajan SK, Mahajan KK, Kumar M
Indian J Chest Dis Allied Sci. 1992
PubMed ID: 1302222
Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.
Matthews RJ, Bowne DB, Flores E, Thomas ML
Mol Cell Biol. 1992
PubMed ID: 1373816
Isolation of a src homology 2-containing tyrosine phosphatase.
Plutzky J, Neel BG, Rosenberg RD
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1736296
Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.
Yi TL, Cleveland JL, Ihle JN
Mol Cell Biol. 1992
PubMed ID: 1732748
Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification.
Yi T, Cleveland JL, Ihle JN
Blood. 1991
PubMed ID: 1932742
A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases.
Shen SH, Bastien L, Posner BI, Chrétien P
Nature. 1991
PubMed ID: 1652101
Different nature of the proliferation defects of GLD, LPR and MEV C57BL/6 mouse lymphoid cells.
Froidevaux S, Kuntz L, Velin D, Loor F
Autoimmunity. 1991
PubMed ID: 1756226
Effect of genetically determined immunodeficiency on epidermal dendritic cell populations in C57BL/6J mice.
Sprecher E, Becker Y, Kraal G, Hall E, Shultz LD
Arch Dermatol Res. 1990
PubMed ID: 2196000
Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev).
Van Zant G, Shultz L
Exp Hematol. 1989
PubMed ID: 2783574
The interaction of the xid and me genes.
Scribner CL, Hansen CT, Klinman DM, Steinberg AD
J Immunol. 1987
PubMed ID: 2884254
Development of plasmacytoid cells with Russell bodies in autoimmune "viable motheaten" mice.
Shultz LD, Coman DR, Lyons BL, Sidman CL, Taylor S
Am J Pathol. 1987
PubMed ID: 3551623
A serum-derived molecule from autoimmune viable motheaten mice potentiates the action of a B cell maturation factor.
Sidman CL, Shultz LD, Evans R
J Immunol. 1985
PubMed ID: 3891855
Effects of the motheaten gene on murine B-cell production.
McCoy KL, Clagett J, Rosse C
Exp Hematol. 1985
PubMed ID: 3873348
Novel B-cell maturation factor from spontaneously autoimmune viable motheaten mice.
Sidman CL, Marshall JD, Masiello NC, Roths JB, Shultz LD
Proc Natl Acad Sci U S A. 1984
PubMed ID: 6334306
"Viable motheaten," a new allele at the motheaten locus. I. Pathology.
Shultz LD, Coman DR, Bailey CL, Beamer WG, Sidman CL
Am J Pathol. 1984
PubMed ID: 6380298
Spontaneous production of colony-stimulating activity by splenic Mac-1 antigen-positive cells from autoimmune motheaten mice.
McCoy KL, Nielson K, Clagett J
J Immunol. 1984
PubMed ID: 6361123
Hematopoietic stem cell function in motheaten mice.
Shultz LD, Bailey CL, Coman DR
Exp Hematol. 1983
PubMed ID: 6350031
Mutations in mice that influence natural killer (NK) cell activity.
Clark EA, Shultz LD, Pollack SB
Immunogenetics. 1981
PubMed ID: 6971254
Phenotypic and functional effects of the motheaten gene on murine B and T lymphocytes.
Davidson WF, Morse HC, Sharrow SO, Chused TM
J Immunol. 1979
PubMed ID: 221571
The mouse mutant "motheaten." II. Functional studies of the immune system.
Sidman CL, Shultz LD, Unanue ER
J Immunol. 1978
PubMed ID: 363947
Pulmonary pathology of the motheaten mouse.
Ward JM
Vet Pathol. 1978
PubMed ID: 664185
Motheater: an immunodeficient mouse with markedly less ability to survive that the nude mouse in a germfree environment.
Lutzner MA, Hansen CT
J Immunol. 1976
PubMed ID: 1270804
Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins.
Shultz LD, Green MC
J Immunol. 1976
PubMed ID: 56406
Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology.
Green MC, Shultz LD
J Hered. 1975
PubMed ID: 1184950

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	5777	15170	116689
EnsEMBL Gene(s)	ENSG00000111679	ENSMUSG00000004266	ENSRNOG00000014294
Unigene	Hs.63489	Mm.271799	Rn.18985
Homologene	PTPN6	Ptpn6	Ptpn6
OMIM	176883	N/A	N/A
GeneCards	PTPN6	N/A	N/A
Beta Cell Genomics	DT.100028513 DT.102841597 DT.121157420 DT.456224 DT.91826354 DT.99987797	DT.493244 DT.91308995 DT.94207958	N/A
Reactome	P29350	N/A	N/A
Plasma Peptide Atlas	ENSP00000326010	N/A	N/A
WikiGenes	5777	15170	116689

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
PTPN6	CDH2	IntAct	empirical	19167335
PTPN6	LILRB2	HPRD	empirical	9842885 9531263
PTPN6	TFG	HPRD, MINT	empirical	15557341
PTPN6	KHDRBS1	HPRD, IntAct	empirical	9045636
PTPN6	LILRB1	BioGRID	empirical	9842885
PTPN6	LILRB4	HPRD	empirical	9151699 9973385
PTPN6	SIGLEC11	HPRD, BioGRID	empirical	11986327
PTPN6	SLAMF6	HPRD, BioGRID	empirical	11489943
PTPN6	FCRL3	BioGRID	empirical	12051764
PTPN6	SIRPA	HPRD, IntAct, BioGRID	empirical	10660565 14662855 8943344 9632768 10660620
PTPN6	CSF2RB	HPRD, BioGRID	empirical	8246974 9162089 9254654
PTPN6	CD300LF	HPRD	empirical	15549731 15184070 14662855
PTPN6	CTNNB1	HPRD	empirical	12571228 15588985
PTPN6	CTNND1	HPRD, BioGRID	empirical	10835420
PTPN6	BTLA	HPRD	empirical	12796776
PTPN6	DOK1	HPRD	empirical	10585470
PTPN6	EGFR	HPRD, BioGRID	empirical	9733788 7673163
PTPN6	EPOR	HPRD, MINT, BioGRID	empirical	7889566 7528577 7228577
PTPN6	ESR1	HPRD, MINT	empirical	7539106
PTPN6	PTK2B	HPRD, BioGRID	empirical	10521452 10747947
PTPN6	MS4A2	HPRD	empirical	9379041
PTPN6	FCGR2B	HPRD, MINT	empirical	7716523 9148918
PTPN6	FLT3	HPRD	empirical	15831474
PTPN6	NR5A2	BioGRID	empirical	11668176
PTPN6	ABL1	HPRD, BioGRID	empirical	12468540 8114715 8692915 10488096 10574931 7512963
PTPN6	GHR	HPRD	empirical	9632636
PTPN6	GRB2	HPRD, IntAct, BioGRID	empirical	11964172 8632004 10660620 10747947
PTPN6	BLNK	HPRD, BioGRID	empirical	11356834 10903736 15588985
PTPN6	PILRB	HPRD	empirical	9632768
PTPN6	PILRA	HPRD, IntAct, MIPS, BioGRID	empirical	10660620 10903717
PTPN6	HOXA10	HPRD, BioGRID	empirical	12145285
PTPN6	TREML1	HPRD, BioGRID	empirical	12393607
PTPN6	IFNAR1	HPRD	empirical	9029147 8524272
PTPN6	FAS	HPRD	empirical	11786908
PTPN6	IL2RB	HPRD	empirical	9520455
PTPN6	IL4R	HPRD, BioGRID	empirical	11714803
PTPN6	IL6ST	HPRD, BioGRID	empirical	10800945
PTPN6	INSR	HPRD, BioGRID	empirical	7512963 12468540 8114715 8692915
PTPN6	JAK1	HPRD, BioGRID	empirical	7629131 9520455
PTPN6	JAK2	HPRD, BioGRID	empirical	8943354 10772872
PTPN6	JAK3	HPRD	empirical	9520455
PTPN6	KDR	HPRD, IntAct	empirical	9405464 16453023 18377662
PTPN6	KIR2DL3	HPRD, MINT	empirical	9148918
PTPN6	KIT	HPRD, BioGRID	empirical	7684496 9528781
PTPN6	KLRB1	HPRD	empirical	10229828
PTPN6	KLRC1	HPRD	empirical	9485206
PTPN6	LAIR1	HPRD, IntAct, BioGRID	empirical	11160222 10660620 10903717 9285412 10764762
PTPN6	LCK	HPRD, IntAct, BioGRID	empirical	8114715 11294838 12468540 8692915 10488096 10574931 7512963 19167335 10617656
PTPN6	LCP2	HPRD, BioGRID	empirical	9765283 8760799 15588985
PTPN6	LIFR	HPRD, BioGRID	empirical	10800945
PTPN6	LYN	HPRD, BioGRID	empirical	10574931 11042209 12468540 8114715 8692915 10488096
PTPN6	SMAD3	IntAct	empirical	18729074
PTPN6	MAP3K4	MINT	empirical	15601262
PTPN6	MYH9	HPRD	empirical	12705885
PTPN6	NOS1	HPRD, BioGRID	empirical	11511520
PTPN6	NTRK1	MINT	empirical	15557341
PTPN6	CUZD1	HPRD	empirical	12361947 15588985
PTPN6	CLEC4A	HPRD	empirical	11178971
PTPN6	PDGFRB	IntAct	empirical	19167335
PTPN6	PECAM1	HPRD, BioGRID, Reactome	empirical	9774457 10350061
PTPN6	PIK3R1	HPRD, IntAct, BioGRID	empirical	11337495 11160222 12196526
PTPN6	PLCB3	IntAct	empirical	19647226
PTPN6	PRKCA	HPRD	empirical	15269224
PTPN6	PRKCD	HPRD, BioGRID	empirical	11723252
PTPN6	PAG1	HPRD, BioGRID	empirical	10790433
PTPN6	KIR2DL5A	HPRD	empirical	15187115
PTPN6	PTPN6	HPRD	empirical	9151699 9973385 8574854 9842885 9531263 11920268 7518460
PTPN6	PTPN11	HPRD	empirical	8541543
PTPN6	PTPRC	HPRD	empirical	10228003 9368621
PTPN6	ROS1	HPRD, MINT, BioGRID	empirical	11266449 17416557
PTPN6	BCR	HPRD, BioGRID	empirical	9211920 9788431
PTPN6	CEACAM1	HPRD	empirical	9867848
PTPN6	SHC1	HPRD	empirical	8541543
PTPN6	SOS1	HPRD	empirical	8632004
PTPN6	SRC	HPRD	empirical	12468645 8647855 9261115
PTPN6	SSTR2	HPRD, BioGRID	empirical	9305905 11920268
PTPN6	STAT5B	HPRD, BioGRID	empirical	9211920
PTPN6	STAT6	HPRD	empirical	12791978
PTPN6	SYK	HPRD, BioGRID	empirical	10072516 11356834 10747947
PTPN6	TNFRSF1A	HPRD	empirical	11786908
PTPN6	TRAF6	HPRD	empirical	14500659
PTPN6	TYK2	HPRD, BioGRID	empirical	7629131 8780698
PTPN6	UBC	BioGRID	empirical	21890473 21906983
PTPN6	VAV1	HPRD, BioGRID	empirical	8632004
PTPN6	ZAP70	HPRD, BioGRID	empirical	8638162 10458769
PTPN6	CXCR4	HPRD	empirical	10506573
PTPN6	TMEM62	HPRD, IntAct	empirical	16169070
PTPN6	C6orf25	HPRD, BioGRID	empirical	11544253
PTPN6	ACTN4	HPRD	empirical	15070900 15588985
PTPN6	TLR10	HPRD	empirical	16482509
PTPN6	IRS4	HPRD	empirical	12774026
PTPN6	CAV1	HPRD, MINT, BioGRID	empirical	12176037
PTPN6	IRS2	HPRD	empirical	12198247
PTPN6	CBL	HPRD, BioGRID	empirical	12176909
PTPN6	ACTN1	HPRD	empirical	15070900
PTPN6	SIGLEC10	HPRD	empirical	12163025
PTPN6	SIGLEC12	HPRD	empirical	11328818
PTPN6	CD247	HPRD	empirical	14672952
PTPN6	CD5	HPRD, BioGRID	empirical	10082557
PTPN6	CD22	HPRD, IntAct, BioGRID	empirical	9890995 7618087 15588985 8627166 11551923 10228003 11356834
PTPN6	CD33	HPRD, BioGRID	empirical	10206955
PTPN6	CD72	HPRD, BioGRID	empirical	9590210 9740800 15588985 12882840 11114375
PTPN6	CD79A	HPRD	empirical	7539038
PTPN6	CD79B	HPRD	empirical	7539038
PTPN6	SPATA2	HPRD	empirical	11160222
PTPN6	GAB2	HPRD, BioGRID	empirical	11895767 11812650