PTK2

Summary Top Help

Gene Description:

PTK2 protein tyrosine kinase 2

Synonyms:

mKIAA4203, pp125FAK, FAK1, Ptk2, p125FAK, Fadk, FRNK, PPP1R71, PTK2, FADK, FAK

Orthologs:

Human PTK2 (protein-coding), Mouse Ptk2 (protein-coding), Rat Ptk2 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 1

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm34	Rat	chr7:96517746..137757704	41.24	447

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr8:141667999..142012315 (344.32 kb) View in Genome Browser

(Mouse) NCBIM37 - chr15:73035535..73253710 (218.18 kb) View in Genome Browser

(Rat) RGSC3.4 - chr7:110933296..111084554 (151.26 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PTK2:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PTK2:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 11

Biocarta: None available

Reactome: 18

NCI-Nature Pathway Interaction Database: 2

Gene Ontology: 68

Nucleotide binding	GO:0000166
Microtubule cytoskeleton organization	GO:0000226
Angiogenesis	GO:0001525
Blood vessel development	GO:0001568
Vasculogenesis	GO:0001570
Neuron migration	GO:0001764
Placenta development	GO:0001890
Positive regulation of protein phosphorylation	GO:0001934
Heart morphogenesis	GO:0003007
Protein kinase activity	GO:0004672
Protein tyrosine kinase activity	GO:0004713
Non-membrane spanning protein tyrosine kinase activity	GO:0004715
Signal transducer activity	GO:0004871
Binding	GO:0005488
Protein binding	GO:0005515
ATP binding	GO:0005524
Nucleus	GO:0005634
Cytoplasm	GO:0005737
Microtubule organizing center	GO:0005815
Cytosol	GO:0005829
Cytoskeleton	GO:0005856
Plasma membrane	GO:0005886
Focal adhesion	GO:0005925
Cell cortex	GO:0005938
Protein phosphorylation	GO:0006468
Apoptotic process	GO:0006915
Cellular component disassembly involved in apoptosis	GO:0006921
Signal complex assembly	GO:0007172
Integrin-mediated signaling pathway	GO:0007229
Axon guidance	GO:0007411
Blood coagulation	GO:0007596
Positive regulation of cell proliferation	GO:0008284
Regulation of cell shape	GO:0008360
JUN kinase binding	GO:0008432
Embryo development	GO:0009790
Regulation of endothelial cell migration	GO:0010594
Positive regulation of phosphatidylinositol 3-kinase cascade	GO:0014068
Apical plasma membrane	GO:0016324
Peptidyl-tyrosine phosphorylation	GO:0018108
Protein kinase binding	GO:0019901
Central nervous system neuron axonogenesis	GO:0021955
Establishment of cell polarity	GO:0030010
Lamellipodium	GO:0030027
Cell junction	GO:0030054
Platelet activation	GO:0030168
Extracellular matrix organization	GO:0030198
Positive regulation of cell migration	GO:0030335
Regulation of Rho GTPase activity	GO:0032319
Regulation of cell adhesion mediated by integrin	GO:0033628
Netrin-activated signaling pathway	GO:0038007
Establishment of nucleus localization	GO:0040023
Regulation of cell proliferation	GO:0042127
SH2 domain binding	GO:0042169
Negative regulation of apoptotic process	GO:0043066
Positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552
Regulation of osteoblast differentiation	GO:0045667
Positive regulation of protein kinase activity	GO:0045860
Negative regulation of organ growth	GO:0046621
Protein autophosphorylation	GO:0046777
Ephrin receptor signaling pathway	GO:0048013
Cell motility	GO:0048870
Negative regulation of axonogenesis	GO:0050771
Regulation of cytoskeleton organization	GO:0051493
Regulation of focal adhesion assembly	GO:0051893
Positive regulation of protein kinase B signaling cascade	GO:0051897
Negative regulation of synapse assembly	GO:0051964
Growth hormone receptor signaling pathway	GO:0060396
Positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	GO:2000060

Publications from PubMed Top Help

Type 1 Diabetes Publications: 4

Publications: 878

c-Cbl Ubiquitin Ligase Regulates Focal Adhesion Protein Turnover and Myofibril Degeneration Induced by Neutrophil Protease Cathepsin G.
Rafiq K, Guo J, Vlasenko L, Guo X, Kolpakov MA, Sanjay A, Houser SR, Sabri A
J Biol Chem. 2012
PubMed ID: 22203672
Focal adhesion kinase governs cardiac concentric hypertrophic growth by activating the AKT and mTOR pathways.
Clemente CF, Xavier-Neto J, Dalla Costa AP, Consonni SR, Antunes JE, Rocco SA, Pereira MB, Judice CC, Strauss B, Joazeiro PP, Matos-Souza JR, Franchini KG
J Mol Cell Cardiol. 2012
PubMed ID: 22056317
FAK promotes recruitment of talin to nascent adhesions to control cell motility.
Lawson C, Lim ST, Uryu S, Chen XL, Calderwood DA, Schlaepfer DD
J Cell Biol. 2012
PubMed ID: 22270917
VEGF-induced vascular permeability is mediated by FAK.
Chen XL, Nam JO, Jean C, Lawson C, Walsh CT, Goka E, Lim ST, Tomar A, Tancioni I, Uryu S, Guan JL, Acevedo LM, Weis SM, Cheresh DA, Schlaepfer DD
Dev Cell. 2012
PubMed ID: 22264731
The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways.
Badgwell DB, Lu Z, Le K, Gao F, Yang M, Suh GK, Bao JJ, Das P, Andreeff M, Chen W, Yu Y, Ahmed AA, S-L Liao W, Bast RC
Oncogene. 2012
PubMed ID: 21643014
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling.
Sandilands E, Serrels B, McEwan DG, Morton JP, Macagno JP, McLeod K, Stevens C, Brunton VG, Langdon WY, Vidal M, Sansom OJ, Dikic I, Wilkinson S, Frame MC
Nat Cell Biol. 2012
PubMed ID: 22138575
Fascin, a novel marker of human hepatic stellate cells, may regulate their proliferation, migration, and collagen gene expression through the FAK-PI3K-Akt pathway.
Uyama N, Iimuro Y, Kawada N, Reynaert H, Suzumura K, Hirano T, Kuroda N, Fujimoto J
Lab Invest. 2012
PubMed ID: 22005766
Cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734.
Wortmann A, He Y, Christensen ME, Linn M, Lumley JW, Pollock PM, Waterhouse NJ, Hooper JD
J Biol Chem. 2011
PubMed ID: 21994943
Myocilin, a glaucoma-associated protein, promotes cell migration through activation of integrin-focal adhesion kinase-serine/threonine kinase signaling pathway.
Kwon HS, Tomarev SI
J Cell Physiol. 2011
PubMed ID: 21656515
Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells.
Li XY, Zhou X, Rowe RG, Hu Y, Schlaepfer DD, Ilić D, Dressler G, Park A, Guan JL, Weiss SJ
J Cell Biol. 2011
PubMed ID: 22105351
Role of receptor for hyaluronic acid-mediated motility (RHAMM) in low molecular weight hyaluronan (LMWHA)-mediated fibrosarcoma cell adhesion.
Kouvidi K, Berdiaki A, Nikitovic D, Katonis P, Afratis N, Hascall VC, Karamanos NK, Tzanakakis GN
J Biol Chem. 2011
PubMed ID: 21914806
Paxillin enables attachment-independent tyrosine phosphorylation of focal adhesion kinase and transformation by RAS.
Wade R, Brimer N, Lyons C, Vande Pol S
J Biol Chem. 2011
PubMed ID: 21900245
Ras-induced and extracellular signal-regulated kinase 1 and 2 phosphorylation-dependent isomerization of protein tyrosine phosphatase (PTP)-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST.
Zheng Y, Yang W, Xia Y, Hawke D, Liu DX, Lu Z
Mol Cell Biol. 2011
PubMed ID: 21876001
Focal adhesion kinase-related nonkinase inhibits vascular smooth muscle cell invasion by focal adhesion targeting, tyrosine 168 phosphorylation, and competition for p130(Cas) binding.
Koshman YE, Chu M, Engman SJ, Kim T, Iyengar R, Robia SL, Samarel AM
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21852560
Suppression of E-cadherin function drives the early stages of Ras-induced squamous cell carcinoma through upregulation of FAK and Src.
Alt-Holland A, Sowalsky AG, Szwec-Levin Y, Shamis Y, Hatch H, Feig LA, Garlick JA
J Invest Dermatol. 2011
PubMed ID: 21716326
Effects of stable knockdown of Aurora kinase A on proliferation, migration, chromosomal instability, and expression of focal adhesion kinase and matrix metalloproteinase-2 in HEp-2 cells.
Zhang H, Chen X, Liu B, Zhou L
Mol Cell Biochem. 2011
PubMed ID: 21590355
ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1.
Sbroggiò M, Bertero A, Velasco S, Fusella F, De Blasio E, Bahou WF, Silengo L, Turco E, Brancaccio M, Tarone G
J Cell Sci. 2011
PubMed ID: 22010199
Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK).
Li G, Du X, Vass WC, Papageorge AG, Lowy DR, Qian X
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21969587
FAK is required for the assembly of podosome rosettes.
Pan YR, Chen CL, Chen HC
J Cell Biol. 2011
PubMed ID: 21969470
A high-resolution molecular atlas of the fetal mouse lower urogenital tract.
Abler LL, Keil KP, Mehta V, Joshi PS, Schmitz CT, Vezina CM
Dev Dyn. 2011
PubMed ID: 21905163
Focal adhesion kinase regulates smooth muscle cell recruitment to the developing vasculature.
Cheng Z, Sundberg-Smith LJ, Mangiante LE, Sayers RL, Hakim ZS, Musunuri S, Maguire CT, Majesky MW, Zhou Z, Mack CP, Taylor JM
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21757658
Effect of focal adhesion kinase on the regulation of realignment and tenogenic differentiation of human mesenchymal stem cells by mechanical stretch.
Xu B, Song G, Ju Y
Connect Tissue Res. 2011
PubMed ID: 21401419
Role of extracellular matrix renal tubulo-interstitial nephritis antigen (TINag) in cell survival utilizing integrin (alpha)vbeta3/focal adhesion kinase (FAK)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B-serine/threonine kinase (AKT) signaling pa
Xie P, Kondeti VK, Lin S, Haruna Y, Raparia K, Kanwar YS
J Biol Chem. 2011
PubMed ID: 21795690
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt.
Mehta RR, Yamada T, Taylor BN, Christov K, King ML, Majumdar D, Lekmine F, Tiruppathi C, Shilkaitis A, Bratescu L, Green A, Beattie CW, Das Gupta TK
Angiogenesis. 2011
PubMed ID: 21667138
EGF-induced ERK-activation downstream of FAK requires rac1-NADPH oxidase.
Flinder LI, Timofeeva OA, Rosseland CM, Wierød L, Huitfeldt HS, Skarpen E
J Cell Physiol. 2011
PubMed ID: 21660950
Integrin-associated tyrosine kinase FAK affects Cbfa1 expression.
Schneider GB, Zaharias R, Seabold D, Stanford C
J Orthop Res. 2011
PubMed ID: 21412826
JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains.
Cho IH, Lee KW, Ha HY, Han PL
Exp Mol Med. 2011
PubMed ID: 21685723
Focal adhesion kinase modulates radial glia-dependent neuronal migration through connexin-26.
Valiente M, Ciceri G, Rico B, Marín O
J Neurosci. 2011
PubMed ID: 21832197
CCN6 as a profibrotic mediator that stimulates the proliferation of lung fibroblasts via the integrin β1/focal adhesion kinase pathway.
Batmunkh R, Nishioka Y, Aono Y, Azuma M, Kinoshita K, Kishi J, Makino H, Kishi M, Takezaki A, Sone S
J Med Invest. 2011
PubMed ID: 21921419
VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation.
Herzog B, Pellet-Many C, Britton G, Hartzoulakis B, Zachary IC
Mol Biol Cell. 2011
PubMed ID: 21653826
Cortactin and focal adhesion kinase as predictors of cancer risk in patients with laryngeal premalignancy.
Rodrigo JP, Álvarez-Alija G, Menéndez ST, Mancebo G, Allonca E, García-Carracedo D, Fresno MF, Suárez C, García-Pedrero JM
Cancer Prev Res (Phila). 2011
PubMed ID: 21646305
Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner.
Shen CJ, Raghavan S, Xu Z, Baranski JD, Yu X, Wozniak MA, Miller JS, Gupta M, Buckbinder L, Chen CS
Exp Cell Res. 2011
PubMed ID: 21640103
SOCS3 promoter methylation is mutually exclusive to EGFR amplification in gliomas and promotes glioma cell invasion through STAT3 and FAK activation.
Lindemann C, Hackmann O, Delic S, Schmidt N, Reifenberger G, Riemenschneider MJ
Acta Neuropathol. 2011
PubMed ID: 21590492
Hypoxic preconditioning enhances bone marrow mesenchymal stem cell migration via Kv2.1 channel and FAK activation.
Hu X, Wei L, Taylor TM, Wei J, Zhou X, Wang JA, Yu SP
Am J Physiol Cell Physiol. 2011
PubMed ID: 21562308
Differential expression of FAK and Pyk2 in metastatic and non-metastatic EL4 lymphoma cell lines.
Zhang Z, Knoepp SM, Ku H, Sansbury HM, Xie Y, Chahal MS, Tomlinson S, Meier KE
Clin Exp Metastasis. 2011
PubMed ID: 21533871
RNA interference-mediated silencing of focal adhesion kinase inhibits growth of human malignant glioma xenograft in nude mice.
Wang GJ, Ma YP, Yang Y, Zhang N, Wang W, Liu SY, Chen LJ, Jiang Y, Zhao X, Wei YQ, Deng HX
Cell Biol Int. 2011
PubMed ID: 21247411
Focal adhesion kinase signaling pathway is involved in mechanotransduction in MG-63 cells.
Wang B, Du T, Wang Y, Yang C, Zhang S, Cao X
Biochem Biophys Res Commun. 2011
PubMed ID: 21693107
Abnormal cell properties and down-regulated FAK-Src complex signaling in B lymphoblasts of autistic subjects.
Wei H, Malik M, Sheikh AM, Merz G, Ted Brown W, Li X
Am J Pathol. 2011
PubMed ID: 21703394
Caveolin-1 and integrin β1 regulate embryonic stem cell proliferation via p38 MAPK and FAK in high glucose.
Lee SH, Lee YJ, Park SW, Kim HS, Han HJ
J Cell Physiol. 2011
PubMed ID: 21506116
Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling.
Schober M, Fuchs E
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21670270
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori.
Tegtmeyer N, Wittelsberger R, Hartig R, Wessler S, Martinez-Quiles N, Backert S
Cell Host Microbe. 2011
PubMed ID: 21669400
[Therapeutic effect of focal adhesion kinase gene silence on leukemia].
Xu LH, Fang JP, Weng WJ, Xu HG, Zhang YT
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011
PubMed ID: 21729532
Down-regulation of focal adhesion kinase by short hairpin RNA increased apoptosis of rat hepatic stellate cells.
An J, Zheng L, Xie S, Dun Z, Hao L, Yao D, Shih DQ, Zhang X
APMIS. 2011
PubMed ID: 21569089
Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF.
Van Landeghem L, Chevalier J, Mahé MM, Wedel T, Urvil P, Derkinderen P, Savidge T, Neunlist M
Am J Physiol Gastrointest Liver Physiol. 2011
PubMed ID: 21350188
Expression and clinical significance of FAK and Src proteins in human endometrial adenocarcinoma.
Chatzizacharias NA, Giaginis C, Gatzidou E, Tsourouflis G, Sfiniadakis I, Alexandrou P, Theocharis SE
Pathol Oncol Res. 2011
PubMed ID: 21058027
Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity.
Fan H, Guan JL
J Biol Chem. 2011
PubMed ID: 21471206
Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases.
Swanson PA, Kumar A, Samarin S, Vijay-Kumar M, Kundu K, Murthy N, Hansen J, Nusrat A, Neish AS
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21555563
Non-Smad transforming growth factor-β signaling regulated by focal adhesion kinase binding the p85 subunit of phosphatidylinositol 3-kinase.
Hong M, Wilkes MC, Penheiter SG, Gupta SK, Edens M, Leof EB
J Biol Chem. 2011
PubMed ID: 21454615
Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.
Plaza-Menacho I, Morandi A, Mologni L, Boender P, Gambacorti-Passerini C, Magee AI, Hofstra RM, Knowles P, McDonald NQ, Isacke CM
J Biol Chem. 2011
PubMed ID: 21454698
A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src.
Wang Y, Cao H, Chen J, McNiven MA
Mol Biol Cell. 2011
PubMed ID: 21411625
Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo.
Kurio N, Shimo T, Fukazawa T, Takaoka M, Okui T, Hassan NM, Honami T, Hatakeyama S, Ikeda M, Naomoto Y, Sasaki A
Exp Cell Res. 2011
PubMed ID: 21338601
Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression.
Kwiatkowska A, Kijewska M, Lipko M, Hibner U, Kaminska B
Biochim Biophys Acta. 2011
PubMed ID: 21276823
Anoikis disruption of focal adhesion-Akt signaling impairs renal cell carcinoma.
Sakamoto S, Schwarze S, Kyprianou N
Eur Urol. 2011
PubMed ID: 21269758
Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients.
Weber F, Cepok S, Wolf C, Berthele A, Uhr M, Bettecken T, Buck D, Hartung HP, Holsboer F, Müller-Myhsok B, Hemmer B
Pharmacogenomics J. 2011
PubMed ID: 21502966
PKCθ signaling is required for myoblast fusion by regulating the expression of caveolin-3 and β1D integrin upstream focal adhesion kinase.
Madaro L, Marrocco V, Fiore P, Aulino P, Smeriglio P, Adamo S, Molinaro M, Bouché M
Mol Biol Cell. 2011
PubMed ID: 21346196
FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion.
Deramaudt TB, Dujardin D, Hamadi A, Noulet F, Kolli K, De Mey J, Takeda K, Rondé P
Mol Biol Cell. 2011
PubMed ID: 21289086
Estrogen receptor-{alpha} promotes endothelial cell motility through focal adhesion kinase.
Sanchez AM, Flamini MI, Zullino S, Gopal S, Genazzani AR, Simoncini T
Mol Hum Reprod. 2011
PubMed ID: 21127007
Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21321210
Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis.
Wang S, Basson MD
Am J Physiol Cell Physiol. 2011
PubMed ID: 21209368
Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells.
Nagaharu K, Zhang X, Yoshida T, Katoh D, Hanamura N, Kozuka Y, Ogawa T, Shiraishi T, Imanaka-Yoshida K
Am J Pathol. 2011
PubMed ID: 21281808
Macrophage motility requires distinct α5β1/FAK and α4β1/paxillin signaling events.
Abshire MY, Thomas KS, Owen KA, Bouton AH
J Leukoc Biol. 2011
PubMed ID: 21084629
Plexin B1 inhibits integrin-dependent pp125FAK and Rho activity in melanoma.
McClelland L, Chen Y, Soong J, Kuo I, Scott G
Pigment Cell Melanoma Res. 2011
PubMed ID: 21029396
Estrogen regulates endometrial cell cytoskeletal remodeling and motility via focal adhesion kinase.
Flamini MI, Sanchez AM, Genazzani AR, Simoncini T
Fertil Steril. 2011
PubMed ID: 20869705
Role of hypoxia-induced fibronectin-integrin β1 expression in embryonic stem cell proliferation and migration: Involvement of PI3K/Akt and FAK.
Lee SH, Lee YJ, Han HJ
J Cell Physiol. 2011
PubMed ID: 20677223
p53-Dependent repression of focal adhesion kinase in response to estradiol in breast cancer cell-lines.
Anaganti S, Fernández-Cuesta L, Langerød A, Hainaut P, Olivier M
Cancer Lett. 2011
PubMed ID: 21071137
Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition.
Chen TH, Chan PC, Chen CL, Chen HC
Oncogene. 2011
PubMed ID: 20802513
FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing.
Owen KA, Abshire MY, Tilghman RW, Casanova JE, Bouton AH
PLoS One. 2011
PubMed ID: 21887232
Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer.
Seong J, Ouyang M, Kim T, Sun J, Wen PC, Lu S, Zhuo Y, Llewellyn NM, Schlaepfer DD, Guan JL, Chien S, Wang Y
Nat Commun. 2011
PubMed ID: 21792185
A novel role of protein tyrosine kinase2 in mediating chloride secretion in human airway epithelial cells.
Liang L, Woodward OM, Chen Z, Cotter R, Guggino WB
PLoS One. 2011
PubMed ID: 21765932
Endothelial cell-specific molecule 2 (ECSM2) localizes to cell-cell junctions and modulates bFGF-directed cell migration via the ERK-FAK pathway.
Shi C, Lu J, Wu W, Ma F, Georges J, Huang H, Balducci J, Chang Y, Huang Y
PLoS One. 2011
PubMed ID: 21720547
Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src.
Fu M, Rao R, Sudhakar D, Hogue CP, Rutta Z, Morales S, Gordon LK, Braun J, Goodglick L, Wadehra M
PLoS One. 2011
PubMed ID: 21637765
Tyrosine phosphatases in the HER2-directed motility of ovarian cancer cells: Involvement of PTPN12, ERK5 and FAK.
Villa-Moruzzi E
Anal Cell Pathol (Amst). 2011
PubMed ID: 21483099
Focal adhesion kinase: exploring Fak structure to gain insight into function.
Hall JE, Fu W, Schaller MD
Int Rev Cell Mol Biol. 2011
PubMed ID: 21482413
Activation of focal adhesion kinase enhances the adhesion of Fusarium solani to human corneal epithelial cells via the tyrosine-specific protein kinase signaling pathway.
Pan X, Wang Y, Zhou Q, Chen P, Xu Y, Chen H, Xie L
Mol Vis. 2011
PubMed ID: 21403855
Androgen-induced cell migration: role of androgen receptor/filamin A association.
Castoria G, D'Amato L, Ciociola A, Giovannelli P, Giraldi T, Sepe L, Paolella G, Barone MV, Migliaccio A, Auricchio F
PLoS One. 2011
PubMed ID: 21359179
G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets.
Bhavaraju K, Lakhani PR, Dorsam RT, Jin J, Hitchcock IS, Sanjay A, Kunapuli SP
PLoS One. 2011
PubMed ID: 21347357
Non-overlapping functions for Pyk2 and FAK in osteoblasts during fluid shear stress-induced mechanotransduction.
Young SR, Hum JM, Rodenberg E, Turner CH, Pavalko FM
PLoS One. 2011
PubMed ID: 21283581
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Heparan sulfate proteoglycans mediate interstitial flow mechanotransduction regulating MMP-13 expression and cell motility via FAK-ERK in 3D collagen.
Shi ZD, Wang H, Tarbell JM
PLoS One. 2011
PubMed ID: 21246051
FAK: dynamic integration of guidance signals at the growth cone.
Chacón MR, Fazzari P
Cell Adh Migr. 2011
PubMed ID: 20953136
Conditional deletion of the focal adhesion kinase FAK alters remodeling of the blood-brain barrier in glioma.
Lee J, Borboa AK, Chun HB, Baird A, Eliceiri BP
Cancer Res. 2010
PubMed ID: 21159635
Growth and differentiation factor-9 promotes adhesive and motile capacity of prostate cancer cells by up-regulating FAK and Paxillin via Smad dependent pathway.
Bokobza SM, Ye L, Kynaston HG, Jiang WG
Oncol Rep. 2010
PubMed ID: 21042764
FAK pathway regulates PGE₂ production in compressed periodontal ligament cells.
Kang YG, Nam JH, Kim KH, Lee KS
J Dent Res. 2010
PubMed ID: 20924071
Focal adhesion kinase (FAK) gene amplification and its clinical implications in gastric cancer.
Park JH, Lee BL, Yoon J, Kim J, Kim MA, Yang HK, Kim WH
Hum Pathol. 2010
PubMed ID: 20869748
Aqueous extract of the medicinal plant Patrinia villosa Juss. induces angiogenesis via activation of focal adhesion kinase.
Jeon J, Lee J, Kim C, An Y, Choi C
Microvasc Res. 2010
PubMed ID: 20594998
Evaluation of FAK and Src expression in human benign and malignant thyroid lesions.
Michailidi C, Giaginis C, Stolakis V, Alexandrou P, Klijanienko J, Delladetsima I, Chatzizacharias N, Tsourouflis G, Theocharis S
Pathol Oncol Res. 2010
PubMed ID: 20405349
Essential role for focal adhesion kinase in regulating stress hematopoiesis.
Vemula S, Ramdas B, Hanneman P, Martin J, Beggs HE, Kapur R
Blood. 2010
PubMed ID: 20664055
Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics.
Canel M, Serrels A, Miller D, Timpson P, Serrels B, Frame MC, Brunton VG
Cancer Res. 2010
PubMed ID: 21045155
Downregulation of Focal Adhesion Kinase (FAK) by cord blood stem cells inhibits angiogenesis in glioblastoma.
Dasari VR, Kaur K, Velpula KK, Dinh DH, Tsung AJ, Mohanam S, Rao JS
Aging (Albany NY). 2010
PubMed ID: 21068464
The FERM domain: organizing the structure and function of FAK.
Frame MC, Patel H, Serrels B, Lietha D, Eck MJ
Nat Rev Mol Cell Biol. 2010
PubMed ID: 20966971
The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia.
Kim DH, Kong JH, Byeun JY, Jung CW, Xu W, Liu X, Kamel-Reid S, Kim YK, Kim HJ, Lipton JH
Clin Cancer Res. 2010
PubMed ID: 20959405
Estrogen receptor-alpha promotes breast cancer cell motility and invasion via focal adhesion kinase and N-WASP.
Sanchez AM, Flamini MI, Baldacci C, Goglia L, Genazzani AR, Simoncini T
Mol Endocrinol. 2010
PubMed ID: 20880986
FRNK inhibition of focal adhesion kinase-dependent signaling and migration in vascular smooth muscle cells.
Koshman YE, Kim T, Chu M, Engman SJ, Iyengar R, Robia SL, Samarel AM
Arterioscler Thromb Vasc Biol. 2010
PubMed ID: 20705914
A human MAP kinase interactome.
Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
Nat Methods. 2010
PubMed ID: 20936779
Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development.
Smeeton J, Zhang X, Bulus N, Mernaugh G, Lange A, Karner CM, Carroll TJ, Fässler R, Pozzi A, Rosenblum ND, Zent R
Development. 2010
PubMed ID: 20823064
P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910.
Li LH, Zheng MH, Luo Q, Ye Q, Feng B, Lu AG, Wang ML, Chen XH, Su LP, Liu BY
Int J Oncol. 2010
PubMed ID: 20811717
Endothelial cell migration during murine yolk sac vascular remodeling occurs by means of a Rac1 and FAK activation pathway in vivo.
Enciso JM, Konecny CM, Karpen HE, Hirschi KK
Dev Dyn. 2010
PubMed ID: 20737513
Protein tyrosine kinase 2 beta (PTK2B), but not focal adhesion kinase (FAK), is expressed in a sexually dimorphic pattern in developing mouse gonads.
Beverdam A, Svingen T, Bagheri-Fam S, McClive P, Sinclair AH, Harley VR, Koopman P
Dev Dyn. 2010
PubMed ID: 20737507
Expression and prognostic significance of focal adhesion kinase in hepatocellular carcinoma.
Yuan Z, Zheng Q, Fan J, Ai KX, Chen J, Huang XY
J Cancer Res Clin Oncol. 2010
PubMed ID: 20151150
Oxazolone-induced over-expression of focal adhesion kinase in colonic epithelial cells of colitis mouse model.
Ma Y, Semba S, Maemoto A, Takeuchi M, Kameshita I, Ishida A, Kato S, Katoh T, Liu Y, Taniguchi T
FEBS Lett. 2010
PubMed ID: 20682312
Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate.
Beinke S, Phee H, Clingan JM, Schlessinger J, Matloubian M, Weiss A
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20805505
Focal adhesion kinase serves as a marker of cervical lymph node metastasis and is a potential therapeutic target in tongue cancer.
Jiang H, Liu L, Ye J, Liu H, Xing S, Wu Y
J Cancer Res Clin Oncol. 2010
PubMed ID: 20127254
Kinetic mechanism and rate-limiting steps of focal adhesion kinase-1.
Schneck JL, Briand J, Chen S, Lehr R, McDevitt P, Zhao B, Smallwood A, Concha N, Oza K, Kirkpatrick R, Yan K, Villa JP, Meek TD, Thrall SH
Biochemistry. 2010
PubMed ID: 20597513
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.
Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, Sears RC, Clarke AR, Frame MC, Sansom OJ
Dev Cell. 2010
PubMed ID: 20708588
ECE-1 influences prostate cancer cell invasion via ET-1-mediated FAK phosphorylation and ET-1-independent mechanisms.
Whyteside AR, Hinsley EE, Lambert LA, McDermott PJ, Turner AJ
Can J Physiol Pharmacol. 2010
PubMed ID: 20725143
The role of focal adhesion kinase in early development.
Chatzizacharias NA, Kouraklis GP, Theocharis SE
Histol Histopathol. 2010
PubMed ID: 20552554
Evaluation of the clinical significance of focal adhesion kinase and SRC expression in human pancreatic ductal adenocarcinoma.
Chatzizacharias NA, Giaginis C, Zizi-Serbetzoglou D, Kouraklis GP, Karatzas G, Theocharis SE
Pancreas. 2010
PubMed ID: 20431421
Suppression of human MDA-MB-435S tumor by U6 promoter-driven short hairpin RNAs targeting focal adhesion kinase.
Huang AL, Wan Y, Liao DY, Hu HZ, Wei L, Wang XH, Wen YJ, Li J, Chen LJ, Kan B, Chen P, Wang YS, Chen X, Zhao X, Deng HX, Wei YQ
J Cancer Res Clin Oncol. 2010
PubMed ID: 20140743
Usage of heparan sulfate, integrins, and FAK in HPV16 infection.
Abban CY, Meneses PI
Virology. 2010
PubMed ID: 20441998
Regulatory effects of nitric oxide on Src kinase, FAK, p130Cas, and receptor protein tyrosine phosphatase alpha (PTP-alpha): a role for the cellular redox environment.
Curcio MF, Batista WL, Linares E, Nascimento FD, Moraes MS, Borges RE, Sap J, Stern A, Monteiro HP
Antioxid Redox Signal. 2010
PubMed ID: 20055753
Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.
Lim ST, Chen XL, Tomar A, Miller NL, Yoo J, Schlaepfer DD
J Biol Chem. 2010
PubMed ID: 20442405
ZF21 protein regulates cell adhesion and motility.
Nagano M, Hoshino D, Sakamoto T, Kawasaki N, Koshikawa N, Seiki M
J Biol Chem. 2010
PubMed ID: 20439989
Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in human gliomas is associated with unfavorable overall survival.
Ding L, Sun X, You Y, Liu N, Fu Z
Transl Res. 2010
PubMed ID: 20621036
Inhibition of podocyte FAK protects against proteinuria and foot process effacement.
Ma H, Togawa A, Soda K, Zhang J, Lee S, Ma M, Yu Z, Ardito T, Czyzyk J, Diggs L, Joly D, Hatakeyama S, Kawahara E, Holzman L, Guan JL, Ishibe S
J Am Soc Nephrol. 2010
PubMed ID: 20522532
Bioluminescent imaging study: FAK inhibitor, PF-562,271, preclinical study in PC3M-luc-C6 local implant and metastasis xenograft models.
Sun H, Pisle S, Gardner ER, Figg WD
Cancer Biol Ther. 2010
PubMed ID: 20495381
Hydrogen peroxide activates focal adhesion kinase and c-Src by a phosphatidylinositol 3 kinase-dependent mechanism and promotes cell migration in Caco-2 cell monolayers.
Basuroy S, Dunagan M, Sheth P, Seth A, Rao RK
Am J Physiol Gastrointest Liver Physiol. 2010
PubMed ID: 20378826
Activation of NF-kappaB by fluid shear stress, but not TNF-alpha, requires focal adhesion kinase in osteoblasts.
Young SR, Gerard-O'Riley R, Harrington M, Pavalko FM
Bone. 2010
PubMed ID: 20353839
Focal adhesion kinase mediates TGF-beta1-induced renal tubular epithelial-to-mesenchymal transition in vitro.
Deng B, Yang X, Liu J, He F, Zhu Z, Zhang C
Mol Cell Biochem. 2010
PubMed ID: 20177740
A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity.
Serrels B, Sandilands E, Serrels A, Baillie G, Houslay MD, Brunton VG, Canel M, Machesky LM, Anderson KI, Frame MC
Curr Biol. 2010
PubMed ID: 20493699
Ovarian cancer ascites protects from TRAIL-induced cell death through alphavbeta5 integrin-mediated focal adhesion kinase and Akt activation.
Lane D, Goncharenko-Khaider N, Rancourt C, Piché A
Oncogene. 2010
PubMed ID: 20400979
Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development.
Zhao X, Peng X, Sun S, Park AY, Guan JL
J Cell Biol. 2010
PubMed ID: 20530207
[Effects of PTK787 on cell proliferation and expression of fak mRNA in K562].
Di XH, Chen RL, Liu XL, Tian C, Guo YN
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010
PubMed ID: 20561409
Contractility modulates cell adhesion strengthening through focal adhesion kinase and assembly of vinculin-containing focal adhesions.
Dumbauld DW, Shin H, Gallant ND, Michael KE, Radhakrishna H, García AJ
J Cell Physiol. 2010
PubMed ID: 20205236
FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex.
Dalla Costa AP, Clemente CF, Carvalho HF, Carvalheira JB, Nadruz W, Franchini KG
Cardiovasc Res. 2010
PubMed ID: 20038548
Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts.
Cai GQ, Zheng A, Tang Q, White ES, Chou CF, Gladson CL, Olman MA, Ding Q
Exp Cell Res. 2010
PubMed ID: 20109444
Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation.
Tcherkezian J, Brittis PA, Thomas F, Roux PP, Flanagan JG
Cell. 2010
PubMed ID: 20434207
Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis.
Sood AK, Armaiz-Pena GN, Halder J, Nick AM, Stone RL, Hu W, Carroll AR, Spannuth WA, Deavers MT, Allen JK, Han LY, Kamat AA, Shahzad MM, McIntyre BW, Diaz-Montero CM, Jennings NB, Lin YG, Merritt WM, DeGeest K, Vivas-Mejia PE, Lopez-Berestein G, Schaller MD, Cole SW, Lutgendorf SK
J Clin Invest. 2010
PubMed ID: 20389021
Focal adhesion kinase, a downstream mediator of Raf-1 signaling, suppresses cellular adhesion, migration, and neuroendocrine markers in BON carcinoid cells.
Ning L, Chen H, Kunnimalaiyaan M
Mol Cancer Res. 2010
PubMed ID: 20407018
Ethanol enhances the interaction of breast cancer cells over-expressing ErbB2 with fibronectin.
Xu M, Bower KA, Chen G, Shi X, Dong Z, Ke Z, Luo J
Alcohol Clin Exp Res. 2010
PubMed ID: 20201928
Identification of focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3-kinase) as Par3 partners by proteomic analysis.
Itoh N, Nakayama M, Nishimura T, Fujisue S, Nishioka T, Watanabe T, Kaibuchi K
Cytoskeleton (Hoboken). 2010
PubMed ID: 20191563
Focal adhesion kinase functions downstream of Sema3A signaling during axonal remodeling.
Chacón MR, Fernández G, Rico B
Mol Cell Neurosci. 2010
PubMed ID: 20159040
FAK activation is required for TNF-alpha-induced IL-6 production in myoblasts.
Tseng WP, Su CM, Tang CH
J Cell Physiol. 2010
PubMed ID: 20082310
Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK).
Chan KT, Bennin DA, Huttenlocher A
J Biol Chem. 2010
PubMed ID: 20150423
Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions.
Schaller MD
J Cell Sci. 2010
PubMed ID: 20332118
Expression of MLN64 influences cellular matrix adhesion of breast cancer cells, the role for focal adhesion kinase.
Cai W, Ye L, Sun J, Mansel RE, Jiang WG
Int J Mol Med. 2010
PubMed ID: 20198306
Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer.
Guan JL
IUBMB Life. 2010
PubMed ID: 20101634
Role of FAK phosphorylation in hypoxia-induced hMSCS migration: involvement of VEGF as well as MAPKS and eNOS pathways.
Lee SH, Lee YJ, Song CH, Ahn YK, Han HJ
Am J Physiol Cell Physiol. 2010
PubMed ID: 20089932
Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation.
Pasapera AM, Schneider IC, Rericha E, Schlaepfer DD, Waterman CM
J Cell Biol. 2010
PubMed ID: 20308429
Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LA, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S
Vaccine. 2010
PubMed ID: 20056178
Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma.
Beierle EA, Ma X, Stewart J, Nyberg C, Trujillo A, Cance WG, Golubovskaya VM
Cell Cycle. 2010
PubMed ID: 20160475
Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation.
Yu T, Junger WG, Yuan C, Jin A, Zhao Y, Zheng X, Zeng Y, Liu J
Am J Physiol Cell Physiol. 2010
PubMed ID: 19889958
JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration.
Li JP, Fu YN, Chen YR, Tan TH
J Biol Chem. 2010
PubMed ID: 20018849
Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/Syntenin.
Hwangbo C, Kim J, Lee JJ, Lee JH
Cancer Res. 2010
PubMed ID: 20145126
Dual action of epidermal growth factor: extracellular signal-stimulated nuclear-cytoplasmic export and coordinated translation of selected messenger RNA.
Tsai NP, Lin YL, Tsui YC, Wei LN
J Cell Biol. 2010
PubMed ID: 20142421
Preliminary crystallographic characterization of the Grb2 SH2 domain in complex with a FAK-derived phosphotyrosyl peptide.
Chen HH, Chen CW, Chang YY, Shen TL, Hsu CH
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010
PubMed ID: 20124721
Activation of RhoA and FAK induces ERK-mediated osteopontin expression in mechanical force-subjected periodontal ligament fibroblasts.
Hong SY, Jeon YM, Lee HJ, Kim JG, Baek JA, Lee JC
Mol Cell Biochem. 2010
PubMed ID: 19798549
Role of FRNK tyrosine phosphorylation in vascular smooth muscle spreading and migration.
Koshman YE, Engman SJ, Kim T, Iyengar R, Henderson KK, Samarel AM
Cardiovasc Res. 2010
PubMed ID: 19793767
Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway.
Li G, Jin R, Norris RA, Zhang L, Yu S, Wu F, Markwald RR, Nanda A, Conway SJ, Smyth SS, Granger DN
Atherosclerosis. 2010
PubMed ID: 19695571
Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival.
Lim ST, Miller NL, Nam JO, Chen XL, Lim Y, Schlaepfer DD
J Biol Chem. 2010
PubMed ID: 19880522
Hypertension promotes phosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 in rats: implication for the pathogenesis of hypertensive vascular disease.
Sugimura K, Fukumoto Y, Nawata J, Wang H, Onoue N, Tada T, Shirato K, Shimokawa H
Tohoku J Exp Med. 2010
PubMed ID: 21068519
Suppression of uPAR retards radiation-induced invasion and migration mediated by integrin β1/FAK signaling in medulloblastoma.
Nalla AK, Asuthkar S, Bhoopathi P, Gujrati M, Dinh DH, Rao JS
PLoS One. 2010
PubMed ID: 20886051
Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium.
Zhang L, Wang D, Jiang W, Edwards D, Qiu W, Barroilhet LM, Rho JH, Jin L, Seethappan V, Vitonis A, Wang J, Mok SC, Crum C, Cramer DW, Ye B
Reprod Biol Endocrinol. 2010
PubMed ID: 20576130
Focal adhesion kinase and p53 signal transduction pathways in cancer.
Golubovskaya VM, Cance W
Front Biosci. 2010
PubMed ID: 20515733
Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase.
Fu XD, Goglia L, Sanchez AM, Flamini M, Giretti MS, Tosi V, Genazzani AR, Simoncini T
Endocr Relat Cancer. 2010
PubMed ID: 20233709
Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway.
Lee DY, Li YS, Chang SF, Zhou J, Ho HM, Chiu JJ, Chien S
J Biol Chem. 2010
PubMed ID: 19889638
Ischemic preconditioning and heat shock activate Akt via a focal adhesion kinase-mediated pathway in Langendorff-perfused adult rat hearts.
Wei H, Vander Heide RS
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 19880666
Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development.
Corsi JM, Houbron C, Billuart P, Brunet I, Bouvrée K, Eichmann A, Girault JA, Enslen H
J Biol Chem. 2009
PubMed ID: 19776009
Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage.
Provenzano PP, Inman DR, Eliceiri KW, Keely PJ
Oncogene. 2009
PubMed ID: 19826415
Neogenin regulates skeletal myofiber size and focal adhesion kinase and extracellular signal-regulated kinase activities in vivo and in vitro.
Bae GU, Yang YJ, Jiang G, Hong M, Lee HJ, Tessier-Lavigne M, Kang JS, Krauss RS
Mol Biol Cell. 2009
PubMed ID: 19812254
Overexpression and significance of focal adhesion kinase in hepatocellular carcinoma and its relationship with HBV infection.
Cai L, Han J, Zhuo X, Xiong Y, Dong J, Li X
Med Oncol. 2009
PubMed ID: 19021002
The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin.
Knezevic N, Tauseef M, Thennes T, Mehta D
J Exp Med. 2009
PubMed ID: 19917775
Role of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175H.
Fanucchi S, Veale RB
FEBS Lett. 2009
PubMed ID: 19857493
Clostridium difficile toxin A binds colonocyte Src causing dephosphorylation of focal adhesion kinase and paxillin.
Kim H, Rhee SH, Pothoulakis C, LaMont JT
Exp Cell Res. 2009
PubMed ID: 19481075
Focal adhesion kinase (FAK): A regulator of CNS myelination.
Forrest AD, Beggs HE, Reichardt LF, Dupree JL, Colello RJ, Fuss B
J Neurosci Res. 2009
PubMed ID: 19224576
Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination.
Chauhan BK, Disanza A, Choi SY, Faber SC, Lou M, Beggs HE, Scita G, Zheng Y, Lang RA
Development. 2009
PubMed ID: 19820184
STEAP4 regulates focal adhesion kinase activation and CpG motifs within STEAP4 promoter region are frequently methylated in DU145, human androgen-independent prostate cancer cells.
Tamura T, Chiba J
Int J Mol Med. 2009
PubMed ID: 19787193
Involvement of focal adhesion kinase in the progression and prognosis of gastrointestinal stromal tumors.
Kamo N, Naomoto Y, Shirakawa Y, Yamatsuji T, Hirota S, Fujiwara Y, Noma K, Sakurama K, Takaoka M, Nagatsuka H, Gunduz M, Matsuoka J, Tanaka N
Hum Pathol. 2009
PubMed ID: 19695682
A preformed signaling complex mediates GnRH-activated ERK phosphorylation of paxillin and FAK at focal adhesions in L beta T2 gonadotrope cells.
Dobkin-Bekman M, Naidich M, Rahamim L, Przedecki F, Almog T, Lim S, Melamed P, Liu P, Wohland T, Yao Z, Seger R, Naor Z
Mol Endocrinol. 2009
PubMed ID: 19628583
Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase.
Kweh F, Zheng M, Kurenova E, Wallace M, Golubovskaya V, Cance WG
Mol Carcinog. 2009
PubMed ID: 19479903
Targeting of the protein interaction site between FAK and IGF-1R.
Zheng D, Kurenova E, Ucar D, Golubovskaya V, Magis A, Ostrov D, Cance WG, Hochwald SN
Biochem Biophys Res Commun. 2009
PubMed ID: 19664602
PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase.
Gupta A, Dey CS
Mol Cell Endocrinol. 2009
PubMed ID: 19501627
Expression of focal adhesion kinase in patients with endometrial cancer: a clinicopathologic study.
Gabriel B, Hasenburg A, Waizenegger M, Orlowska-Volk M, Stickeler E, zur Hausen A
Int J Gynecol Cancer. 2009
PubMed ID: 19823058
beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity.
Zhang X, Mernaugh G, Yang DH, Gewin L, Srichai MB, Harris RC, Iturregui JM, Nelson RD, Kohan DE, Abrahamson D, Fässler R, Yurchenco P, Pozzi A, Zent R
Development. 2009
PubMed ID: 19710172
Morphological changes and molecular expressions of hepatocellular carcinoma cells in three-dimensional culture model.
Wu YM, Tang J, Zhao P, Chen ZN, Jiang JL
Exp Mol Pathol. 2009
PubMed ID: 19615356
Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells.
Petzold T, Orr AW, Hahn C, Jhaveri KA, Parsons JT, Schwartz MA
Am J Physiol Cell Physiol. 2009
PubMed ID: 19587216
Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility.
van Miltenburg MH, Lalai R, de Bont H, van Waaij E, Beggs H, Danen EH, van de Water B
FASEB J. 2009
PubMed ID: 19584305
Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility.
Tomar A, Schlaepfer DD
Curr Opin Cell Biol. 2009
PubMed ID: 19525103
Osteopontin increases migration and MMP-9 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells.
Chen YJ, Wei YY, Chen HT, Fong YC, Hsu CJ, Tsai CH, Hsu HC, Liu SH, Tang CH
J Cell Physiol. 2009
PubMed ID: 19475568
Overexpressed focal adhesion kinase predicts a higher incidence of extrahepatic metastasis and worse survival in hepatocellular carcinoma.
Jan YJ, Ko BS, Hsu C, Chang TC, Chen SC, Wang J, Liou JY
Hum Pathol. 2009
PubMed ID: 19454363
SHP-2 regulates myogenesis by coupling to FAK signaling pathway.
de Oliveira MV, Marin TM, Clemente CF, Costa AP, Judice CC, Franchini KG
FEBS Lett. 2009
PubMed ID: 19698715
Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor.
Andersson S, D'Arcy P, Larsson O, Sehat B
Biochem Biophys Res Commun. 2009
PubMed ID: 19545541
Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2.
Luo SW, Zhang C, Zhang B, Kim CH, Qiu YZ, Du QS, Mei L, Xiong WC
EMBO J. 2009
PubMed ID: 19661918
[Effects of FAK expression level on proliferation and motility of colorectal carcinoma cells]
Pan N, Zhang AR, Mu MS, Hou YC
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009
PubMed ID: 19737461
Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.
Guilmatre A, Dubourg C, Mosca AL, Legallic S, Goldenberg A, Drouin-Garraud V, Layet V, Rosier A, Briault S, Bonnet-Brilhault F, Laumonnier F, Odent S, Le Vacon G, Joly-Helas G, David V, Bendavid C, Pinoit JM, Henry C, Impallomeni C, Germano E, Tortorella G, Di Rosa G, Barthelemy C, Andres C, Faivre L, Frébourg T, Saugier Veber P, Campion D
Arch Gen Psychiatry. 2009
PubMed ID: 19736351
Mechanical stretch decreases FAK phosphorylation and reduces cell migration through loss of JIP3-induced JNK phosphorylation in airway epithelial cells.
Desai LP, White SR, Waters CM
Am J Physiol Lung Cell Mol Physiol. 2009
PubMed ID: 19574423
Knockdown of focal adhesion kinase reverses colon carcinoma multicellular resistance.
Chen YY, Wang ZX, Chang PA, Li JJ, Pan F, Yang L, Bian ZH, Zou L, He JM, Liang HJ
Cancer Sci. 2009
PubMed ID: 19500106
B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading.
Tse KW, Dang-Lawson M, Lee RL, Vong D, Bulic A, Buckbinder L, Gold MR
J Biol Chem. 2009
PubMed ID: 19561089
Peptidoglycan enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, focal adhesion kinase, Akt, and AP-1- dependent pathway.
Chiu YC, Lin CY, Chen CP, Huang KC, Tong KM, Tzeng CY, Lee TS, Hsu HC, Tang CH
J Immunol. 2009
PubMed ID: 19635908
Src and FAK mediate cell-matrix adhesion-dependent activation of Met during transformation of breast epithelial cells.
Hui AY, Meens JA, Schick C, Organ SL, Qiao H, Tremblay EA, Schaeffer E, Uniyal S, Chan BM, Elliott BE
J Cell Biochem. 2009
PubMed ID: 19533669
Protein chip analysis of pluripotency-associated proteins in NIH3T3 fibroblast.
Ajjappala BS, Kim MS, Kim EY, Kim JH, Kang IC, Baek KH
Proteomics. 2009
PubMed ID: 19701907
Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model.
Slack-Davis JK, Hershey ED, Theodorescu D, Frierson HF, Parsons JT
Mol Cancer Ther. 2009
PubMed ID: 19671741
Focal adhesion kinase (FAK) immunocytochemical expression in breast ductal invasive carcinoma (DIC): correlation with clinicopathological parameters and tumor proliferative capacity.
Theocharis SE, Klijanienko JT, Padoy E, Athanassiou S, Sastre-Garau XX
Med Sci Monit. 2009
PubMed ID: 19644410
FAK, PIP5KIgamma and gelsolin cooperatively mediate force-induced expression of alpha-smooth muscle actin.
Chan MW, Arora PD, Bozavikov P, McCulloch CA
J Cell Sci. 2009
PubMed ID: 19596799
Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development.
Vallejo-Illarramendi A, Zang K, Reichardt LF
J Clin Invest. 2009
PubMed ID: 19587446
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG, Smith RD, Wiley HS, Qian WJ
J Proteome Res. 2009
PubMed ID: 19534553
Differential effects of Pyk2 and FAK on the hypertrophic response of cardiac myocytes.
Menashi EB, Loftus JC
Cell Tissue Res. 2009
PubMed ID: 19484266
Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis.
Chu PY, Huang LY, Hsu CH, Liang CC, Guan JL, Hung TH, Shen TL
J Biol Chem. 2009
PubMed ID: 19473962
Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.
Kiely PA, Baillie GS, Barrett R, Buckley DA, Adams DR, Houslay MD, O'Connor R
J Biol Chem. 2009
PubMed ID: 19423701
Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals.
Kasorn A, Alcaide P, Jia Y, Subramanian KK, Sarraj B, Li Y, Loison F, Hattori H, Silberstein LE, Luscinskas WF, Luo HR
J Immunol. 2009
PubMed ID: 19561112
Focal adhesion kinase is a load-dependent governor of the slow contractile and oxidative muscle phenotype.
Durieux AC, D'Antona G, Desplanches D, Freyssenet D, Klossner S, Bottinelli R, Flück M
J Physiol. 2009
PubMed ID: 19470782
Cyclic stretch reduces myofibrillar protein synthesis despite increases in FAK and anabolic signalling in L6 cells.
Atherton PJ, Szewczyk NJ, Selby A, Rankin D, Hillier K, Smith K, Rennie MJ, Loughna PT
J Physiol. 2009
PubMed ID: 19470773
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.
Zheng Y, Xia Y, Hawke D, Halle M, Tremblay ML, Gao X, Zhou XZ, Aldape K, Cobb MH, Xie K, He J, Lu Z
Mol Cell. 2009
PubMed ID: 19595712
[The influence of down-regulation of focal adhesion kinase by RNA interference on the adhesion and migration of rat hepatic stellate cells in vitro].
An JY, Zhang XL, Yao DM, Dun ZN, Xie SR, Hao LS
Zhonghua Gan Zang Bing Za Zhi. 2009
PubMed ID: 19912685
Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1.
Demers MJ, Thibodeau S, Noël D, Fujita N, Tsuruo T, Gauthier R, Arguin M, Vachon PH
J Cell Biochem. 2009
PubMed ID: 19479902
Focal adhesion kinase signaling regulates the expression of caveolin 3 and beta1 integrin, genes essential for normal myoblast fusion.
Quach NL, Biressi S, Reichardt LF, Keller C, Rando TA
Mol Biol Cell. 2009
PubMed ID: 19458188
Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration.
Chen SC, Khanna RS, Bessette DC, Samayawardhena LA, Pallen CJ
Am J Physiol Cell Physiol. 2009
PubMed ID: 19420001
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
An occludin-focal adhesion kinase protein complex at the blood-testis barrier: a study using the cadmium model.
Siu ER, Wong EW, Mruk DD, Sze KL, Porto CS, Cheng CY
Endocrinology. 2009
PubMed ID: 19213829
Increased expression of focal adhesion kinase correlates with cellular proliferation and apoptosis during 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis.
Xia J, Lv N, Hong Y, Li C, Tao X, Chen X, Cheng B
J Oral Pathol Med. 2009
PubMed ID: 19141060
Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity.
Shi Y, Pontrello CG, DeFea KA, Reichardt LF, Ethell IM
J Neurosci. 2009
PubMed ID: 19553453
Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs.
Shibue T, Weinberg RA
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19502425
Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase.
Gupta SK, Vlahakis NE
J Cell Sci. 2009
PubMed ID: 19470583
The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase.
Schlomann U, Schwamborn JC, Müller M, Fässler R, Püschel AW
J Cell Sci. 2009
PubMed ID: 19454481
Focal adhesion kinase is a blood-testis barrier regulator.
Siu ER, Wong EW, Mruk DD, Porto CS, Cheng CY
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19470647
A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells.
Tomar A, Lim ST, Lim Y, Schlaepfer DD
J Cell Sci. 2009
PubMed ID: 19435801
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Fibronectin and focal adhesion kinase small interfering RNA modulate rat retinal Müller cells adhesion and migration.
Wang XL, Yu T, Zhang JS, Yan QC, Luo YH
Cell Mol Neurobiol. 2009
PubMed ID: 19172391
Prognostic value of CXCR4 and FAK expression in acute myelogenous leukemia.
Tavernier-Tardy E, Cornillon J, Campos L, Flandrin P, Duval A, Nadal N, Guyotat D
Leuk Res. 2009
PubMed ID: 19042019
Expression and clinical significance of focal adhesion kinase in the two distinct histological types, intestinal and diffuse, of human gastric adenocarcinoma.
Giaginis CT, Vgenopoulou S, Tsourouflis GS, Politi EN, Kouraklis GP, Theocharis SE
Pathol Oncol Res. 2009
PubMed ID: 18987997
Transient expression of FRNK reveals stage-specific requirement for focal adhesion kinase activity in cardiac growth.
DiMichele LA, Hakim ZS, Sayers RL, Rojas M, Schwartz RJ, Mack CP, Taylor JM
Circ Res. 2009
PubMed ID: 19372463
Integrin-mediated axoglial interactions initiate myelination in the central nervous system.
Câmara J, Wang Z, Nunes-Fonseca C, Friedman HC, Grove M, Sherman DL, Komiyama NH, Grant SG, Brophy PJ, Peterson A, ffrench-Constant C
J Cell Biol. 2009
PubMed ID: 19451276
Arf GTPase-activating protein AGAP2 regulates focal adhesion kinase activity and focal adhesion remodeling.
Zhu Y, Wu Y, Kim JI, Wang Z, Daaka Y, Nie Z
J Biol Chem. 2009
PubMed ID: 19318351
CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells.
Tan TW, Lai CH, Huang CY, Yang WH, Chen HT, Hsu HC, Fong YC, Tang CH
J Cell Biochem. 2009
PubMed ID: 19301259
Nudel and FAK as antagonizing strength modulators of nascent adhesions through paxillin.
Shan Y, Yu L, Li Y, Pan Y, Zhang Q, Wang F, Chen J, Zhu X
PLoS Biol. 2009
PubMed ID: 19492042
FAK mediates the inhibition of glioma cell migration by truncated 24 kDa FGF-2.
Lin AH, Eliceiri BP, Levin EG
Biochem Biophys Res Commun. 2009
PubMed ID: 19303400
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
FAK signalling mediates NF-kappaB activation by mechanical stress in cardiac myocytes.
Crosara-Alberto DP, Inoue RY, Costa CR
Clin Chim Acta. 2009
PubMed ID: 19361463
FAK silencing inhibits leukemogenesis in BCR/ABL-transformed hematopoietic cells.
Le Y, Xu L, Lu J, Fang J, Nardi V, Chai L, Silberstein LE
Am J Hematol. 2009
PubMed ID: 19358301
Role of ERK/mTOR signaling in TGFbeta-modulated focal adhesion kinase mRNA stability and protein synthesis in cultured rat IEC-6 intestinal epithelial cells.
Suer S, Ampasala D, Walsh MF, Basson MD
Cell Tissue Res. 2009
PubMed ID: 19340459
Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes.
Oh MA, Choi S, Lee MJ, Choi MC, Lee SA, Ko W, Cance WG, Oh ES, Buday L, Kim SH, Lee JW
Biochim Biophys Acta. 2009
PubMed ID: 19339212
Focal adhesion kinase modulates cell adhesion strengthening via integrin activation.
Michael KE, Dumbauld DW, Burns KL, Hanks SK, García AJ
Mol Biol Cell. 2009
PubMed ID: 19297531
ARHGAP21 modulates FAK activity and impairs glioblastoma cell migration.
Bigarella CL, Borges L, Costa FF, Saad ST
Biochim Biophys Acta. 2009
PubMed ID: 19268501
FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion.
Chan KT, Cortesio CL, Huttenlocher A
J Cell Biol. 2009
PubMed ID: 19364917
Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system.
Pereira JA, Benninger Y, Baumann R, Gonçalves AF, Ozçelik M, Thurnherr T, Tricaud N, Meijer D, Fässler R, Suter U, Relvas JB
J Cell Biol. 2009
PubMed ID: 19349584
Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis.
Park AY, Shen TL, Chien S, Guan JL
J Biol Chem. 2009
PubMed ID: 19201755
Focal adhesion kinase (FAK) involvement in human endometrial remodeling during the menstrual cycle.
Orazizadeh M, Rashidi I, Saremi J, Latifi M
Iran Biomed J. 2009
PubMed ID: 19471549
[Role of focal adhesion kinase in the hypoxia-induced invasion of SMMC-7721 cells].
Yan W, Tian DA, Fu Y, Liao JZ, Xia LM, Luo M, Zhu Q
Zhonghua Gan Zang Bing Za Zhi. 2009
PubMed ID: 19403028
PPARdelta activation inhibits angiotensin II induced cardiomyocyte hypertrophy by suppressing intracellular Ca2+ signaling pathway.
Lee KS, Park JH, Lee S, Lim HJ, Park HY
J Cell Biochem. 2009
PubMed ID: 19224536
Focal adhesion kinase and cancer.
Golubovskaya VM, Kweh FA, Cance WG
Histol Histopathol. 2009
PubMed ID: 19224453
FXR promotes endothelial cell motility through coordinated regulation of FAK and MMP-9.
Das A, Yaqoob U, Mehta D, Shah VH
Arterioscler Thromb Vasc Biol. 2009
PubMed ID: 19150878
A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling.
Sawhney RS, Liu W, Brattain MG
J Cell Physiol. 2009
PubMed ID: 19089993
Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia.
Kim DH, Xu W, Ma C, Liu X, Siminovitch K, Messner HA, Lipton JH
Blood. 2009
PubMed ID: 19141860
Expression of FAK and PTEN in bronchioloalveolar carcinoma and lung adenocarcinoma.
Wang C, Yang R, Yue D, Zhang Z
Lung. 2009
PubMed ID: 19242756
Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation.
Akhtar N, Marlow R, Lambert E, Schatzmann F, Lowe ET, Cheung J, Katz E, Li W, Wu C, Dedhar S, Naylor MJ, Streuli CH
Development. 2009
PubMed ID: 19211680
Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility.
Papusheva E, Mello de Queiroz F, Dalous J, Han Y, Esposito A, Jares-Erijmanxa EA, Jovin TM, Bunt G
J Cell Sci. 2009
PubMed ID: 19208768
Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G.
Noda T, Iwai S, Hamada M, Fujita Y, Yura Y
Apoptosis. 2009
PubMed ID: 19199036
Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration.
Manso AM, Kang SM, Plotnikov SV, Thievessen I, Oh J, Beggs HE, Ross RS
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19136609
Quantification of focal adhesion kinase activation loop phosphorylation as a biomarker of Src activity.
Ciccimaro E, Hanks SK, Blair IA
Mol Pharmacol. 2009
PubMed ID: 19098120
Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts.
Young SR, Gerard-O'Riley R, Kim JB, Pavalko FM
J Bone Miner Res. 2009
PubMed ID: 19016591
Targeting of focal adhesion kinase by small interfering RNAs reduces chondrocyte redifferentiation capacity in alginate beads culture with type II collagen.
Kim YH, Lee JW
J Cell Physiol. 2009
PubMed ID: 19006177
Stoichiometry of molecular complexes at adhesions in living cells.
Digman MA, Wiseman PW, Choi C, Horwitz AR, Gratton E
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19168634
Comparing the mechanical influence of vinculin, focal adhesion kinase and p53 in mouse embryonic fibroblasts.
Klemm AH, Diez G, Alonso JL, Goldmann WH
Biochem Biophys Res Commun. 2009
PubMed ID: 19126403
[The role of PTEN-FAK signaling pathway in metastasis and invasive ability of leukemia cells]
Cheng ZY, Guo XL, Li SH, Wang SY, Yang XY, Xue F, Wen SP, Pan L
Zhonghua Xue Ye Xue Za Zhi. 2009
PubMed ID: 19563023
Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling.
Pylayeva Y, Gillen KM, Gerald W, Beggs HE, Reichardt LF, Giancotti FG
J Clin Invest. 2009
PubMed ID: 19147981
FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas.
Zouq NK, Keeble JA, Lindsay J, Valentijn AJ, Zhang L, Mills D, Turner CE, Streuli CH, Gilmore AP
J Cell Sci. 2009
PubMed ID: 19126677
FAK regulates cardiomyocyte survival following ischemia/reperfusion.
Hakim ZS, DiMichele LA, Rojas M, Meredith D, Mack CP, Taylor JM
J Mol Cell Cardiol. 2009
PubMed ID: 19028502
The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cells.
Zhao Y, Min C, Vora SR, Trackman PC, Sonenshein GE, Kirsch KH
J Biol Chem. 2009
PubMed ID: 19029090
Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.
Luo M, Fan H, Nagy T, Wei H, Wang C, Liu S, Wicha MS, Guan JL
Cancer Res. 2009
PubMed ID: 19147559
EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility.
Yamazaki T, Masuda J, Omori T, Usui R, Akiyama H, Maru Y
J Cell Sci. 2009
PubMed ID: 19118217
Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis.
Srinivasan R, Zabuawala T, Huang H, Zhang J, Gulati P, Fernandez S, Karlo JC, Landreth GE, Leone G, Ostrowski MC
PLoS One. 2009
PubMed ID: 20011539
The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis.
Golubovskaya VM, Zheng M, Zhang L, Li JL, Cance WG
BMC Cancer. 2009
PubMed ID: 19671193
Gonadotropin-releasing hormone (GnRH)-I and GnRH-II induce cell growth inhibition in human endometrial cancer cells: involvement of integrin beta3 and focal adhesion kinase.
Park DW, Choi KC, MacCalman CD, Leung PC
Reprod Biol Endocrinol. 2009
PubMed ID: 19656390
Integrin-linked kinase: a multi-functional regulator modulating extracellular pressure-stimulated cancer cell adhesion through focal adhesion kinase and AKT.
Wang S, Basson MD
Cell Oncol. 2009
PubMed ID: 19633364
NK4, an HGF antagonist, prevents hematogenous pulmonary metastasis by inhibiting adhesion of CT26 cells to endothelial cells.
Kubota T, Taiyoh H, Matsumura A, Murayama Y, Ichikawa D, Okamoto K, Fujiwara H, Ikoma H, Nakanishi M, Kikuchi S, Sakakura C, Ochiai T, Kokuba Y, Taniguchi H, Sonoyama T, Matsumoto K, Nakamura T, Otsuji E
Clin Exp Metastasis. 2009
PubMed ID: 19234748
Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion.
Sachdev S, Bu Y, Gelman IH
BMC Cancer. 2009
PubMed ID: 19138410
Focal adhesion kinase: important to prostaglandin E2-mediated adhesion, migration and invasion in hepatocellular carcinoma cells.
Bai XM, Zhang W, Liu NB, Jiang H, Lou KX, Peng T, Ma J, Zhang L, Zhang H, Leng J
Oncol Rep. 2009
PubMed ID: 19082453
A cross-talk between oncogenic Ras and tumor suppressor PTEN through FAK Tyr861 phosphorylation in NIH/3T3 mouse embryonic fibroblasts.
Bahk YY, Cho IH, Kim TS
Biochem Biophys Res Commun. 2008
PubMed ID: 19000654
MR-1 modulates proliferation and migration of human hepatoma HepG2 cells through myosin light chains-2 (MLC2)/focal adhesion kinase (FAK)/Akt signaling pathway.
Ren K, Jin H, Bian C, He H, Liu X, Zhang S, Wang Y, Shao RG
J Biol Chem. 2008
PubMed ID: 18948272
Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection.
Del Re DP, Miyamoto S, Brown JH
J Biol Chem. 2008
PubMed ID: 18854312
[The expression and significance of integrin beta1 and focal adhesion kinase and its clinical value in laryngeal carcinoma].
Wei G, Du Y, Yang C, Zhang X
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008
PubMed ID: 19297850
TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells.
Wang ZG, Fukazawa T, Nishikawa T, Watanabe N, Sakurama K, Motoki T, Takaoka M, Hatakeyama S, Omori O, Ohara T, Tanabe S, Fujiwara Y, Shirakawa Y, Yamatsuji T, Tanaka N, Naomoto Y
Oncol Rep. 2008
PubMed ID: 19020730
FRNK expression promotes smooth muscle cell maturation during vascular development and after vascular injury.
Sayers RL, Sundberg-Smith LJ, Rojas M, Hayasaka H, Parsons JT, Mack CP, Taylor JM
Arterioscler Thromb Vasc Biol. 2008
PubMed ID: 18787183
Mutation of Y925F in focal adhesion kinase (FAK) suppresses melanoma cell proliferation and metastasis.
Kaneda T, Sonoda Y, Ando K, Suzuki T, Sasaki Y, Oshio T, Tago M, Kasahara T
Cancer Lett. 2008
PubMed ID: 18606490
[The role of FAK-ERK signal transduction pathway in apoptosis of hepatic stellate cell]
Shen JG, Zhang XL, Huo XX
Zhonghua Gan Zang Bing Za Zhi. 2008
PubMed ID: 19032871
Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer.
Provenzano PP, Inman DR, Eliceiri KW, Beggs HE, Keely PJ
Am J Pathol. 2008
PubMed ID: 18845837
Focal adhesion kinase-related proline-rich tyrosine kinase 2 and focal adhesion kinase are co-overexpressed in early-stage and invasive ErbB-2-positive breast cancer and cooperate for breast cancer cell tumorigenesis and invasiveness.
Behmoaram E, Bijian K, Jie S, Xu Y, Darnel A, Bismar TA, Alaoui-Jamali MA
Am J Pathol. 2008
PubMed ID: 18832579
Formation of Kv2.1-FAK complex as a mechanism of FAK activation, cell polarization and enhanced motility.
Wei JF, Wei L, Zhou X, Lu ZY, Francis K, Hu XY, Liu Y, Xiong WC, Zhang X, Banik NL, Zheng SS, Yu SP
J Cell Physiol. 2008
PubMed ID: 18615577
Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion.
Lin KT, Sloniowski S, Ethell DW, Ethell IM
J Biol Chem. 2008
PubMed ID: 18713744
Loss of protein kinase Cepsilon results in impaired cutaneous wound closure and myofibroblast function.
Leask A, Shi-Wen X, Khan K, Chen Y, Holmes A, Eastwood M, Denton CP, Black CM, Abraham DJ
J Cell Sci. 2008
PubMed ID: 18827016
Focal adhesion kinase regulates cell-cell contact formation in epithelial cells via modulation of Rho.
Playford MP, Vadali K, Cai X, Burridge K, Schaller MD
Exp Cell Res. 2008
PubMed ID: 18773890
Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase/Src and mTOR pathways.
Marin TM, Clemente CF, Santos AM, Picardi PK, Pascoal VD, Lopes-Cendes I, Saad MJ, Franchini KG
Circ Res. 2008
PubMed ID: 18757826
Biphasic function of focal adhesion kinase in endothelial tube formation induced by fibril-forming collagens.
Nakamura J, Shigematsu S, Yamauchi K, Takeda T, Yamazaki M, Kakizawa T, Hashizume K
Biochem Biophys Res Commun. 2008
PubMed ID: 18680726
Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner.
Ding Q, Gladson CL, Wu H, Hayasaka H, Olman MA
J Biol Chem. 2008
PubMed ID: 18669633
ARHGAP21 associates with FAK and PKCzeta and is redistributed after cardiac pressure overload.
Borges L, Bigarella CL, Baratti MO, Crosara-Alberto DP, Joazeiro PP, Franchini KG, Costa FF, Saad ST
Biochem Biophys Res Commun. 2008
PubMed ID: 18662671
Focal adhesion kinase controls aggressive phenotype of androgen-independent prostate cancer.
Johnson TR, Khandrika L, Kumar B, Venezia S, Koul S, Chandhoke R, Maroni P, Donohue R, Meacham RB, Koul HK
Mol Cancer Res. 2008
PubMed ID: 18922979
The expression of integrinbeta1 and FAK in pituitary adenomas and their correlation with invasiveness.
Wang F, Shu K, Lei T, Xue D
J Huazhong Univ Sci Technolog Med Sci. 2008
PubMed ID: 18846341
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Overexpression of HAb18G/CD147 promotes invasion and metastasis via alpha3beta1 integrin mediated FAK-paxillin and FAK-PI3K-Ca2+ pathways.
Tang J, Wu YM, Zhao P, Yang XM, Jiang JL, Chen ZN
Cell Mol Life Sci. 2008
PubMed ID: 18695939
Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly.
Vitale S, Avizienyte E, Brunton VG, Frame MC
Eur J Cell Biol. 2008
PubMed ID: 18562041
Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation.
Liu Z, Zhang HM, Yuan J, Lim T, Sall A, Taylor GA, Yang D
Cell Microbiol. 2008
PubMed ID: 18452580
Genetic upregulation of matriptase-2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation.
Sanders AJ, Parr C, Martin TA, Lane J, Mason MD, Jiang WG
J Cell Physiol. 2008
PubMed ID: 18449907
In vivo inhibition of focal adhesion kinase causes insulin resistance.
Bisht B, Srinivasan K, Dey CS
J Physiol. 2008
PubMed ID: 18587052
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
FERM control of FAK function: implications for cancer therapy.
Lim ST, Mikolon D, Stupack DG, Schlaepfer DD
Cell Cycle. 2008
PubMed ID: 18677107
Heat stress activates AKT via focal adhesion kinase-mediated pathway in neonatal rat ventricular myocytes.
Wei H, Vander Heide RS
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 18539755
Expression of integrinalpha5beta1, focal adhesion kinase and integrin-linked kinase in rat condylar cartilage during mandibular lateral displacement.
Liu C, Kaneko S, Soma K
Arch Oral Biol. 2008
PubMed ID: 18359002
Regulation of estrogen rapid signaling through arginine methylation by PRMT1.
Le Romancer M, Treilleux I, Leconte N, Robin-Lespinasse Y, Sentis S, Bouchekioua-Bouzaghou K, Goddard S, Gobert-Gosse S, Corbo L
Mol Cell. 2008
PubMed ID: 18657504
Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer.
Aponte M, Jiang W, Lakkis M, Li MJ, Edwards D, Albitar L, Vitonis A, Mok SC, Cramer DW, Ye B
Cancer Res. 2008
PubMed ID: 18632638
Integrin beta1 is involved in the signaling of glial cell line-derived neurotrophic factor.
Cao JP, Yu JK, Li C, Sun Y, Yuan HH, Wang HJ, Gao DS
J Comp Neurol. 2008
PubMed ID: 18465789
FAK nuclear export signal sequences.
Ossovskaya V, Lim ST, Ota N, Schlaepfer DD, Ilic D
FEBS Lett. 2008
PubMed ID: 18549812
Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression.
Yan J, Erdem H, Li R, Cai Y, Ayala G, Ittmann M, Yu-Lee LY, Tsai SY, Tsai MJ
Cancer Res. 2008
PubMed ID: 18593949
Elk-1 associates with FAK, regulates the expression of FAK and MAP kinases as well as apoptosis in HK-2 cells.
Mamali I, Kotsantis P, Lampropoulou M, Marmaras VJ
J Cell Physiol. 2008
PubMed ID: 18247360
The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription.
Sundberg-Smith LJ, DiMichele LA, Sayers RL, Mack CP, Taylor JM
Circ Res. 2008
PubMed ID: 18497331
Focal adhesion kinase expression in human neuroblastoma: immunohistochemical and real-time PCR analyses.
Beierle EA, Massoll NA, Hartwich J, Kurenova EV, Golubovskaya VM, Cance WG, McGrady P, London WB
Clin Cancer Res. 2008
PubMed ID: 18519756
HSP27 regulates cell adhesion and invasion via modulation of focal adhesion kinase and MMP-2 expression.
Lee JW, Kwak HJ, Lee JJ, Kim YN, Lee JW, Park MJ, Jung SE, Hong SI, Lee JH, Lee JS
Eur J Cell Biol. 2008
PubMed ID: 18472181
FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells.
Liu W, Bloom DA, Cance WG, Kurenova EV, Golubovskaya VM, Hochwald SN
Carcinogenesis. 2008
PubMed ID: 18263593
Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells.
Wang X, Urvalek AM, Liu J, Zhao J
J Biol Chem. 2008
PubMed ID: 18353772
Caveolin-1 up-regulation during epithelial to mesenchymal transition is mediated by focal adhesion kinase.
Bailey KM, Liu J
J Biol Chem. 2008
PubMed ID: 18332144
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice.
Peng X, Wu X, Druso JE, Wei H, Park AY, Kraus MS, Alcaraz A, Chen J, Chien S, Cerione RA, Guan JL
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18448675
NG2, a novel proapoptotic receptor, opposes integrin alpha4 to mediate anoikis through PKCalpha-dependent suppression of FAK phosphorylation.
Joo NE, Watanabe T, Chen C, Chekenya M, Stallcup WB, Kapila YL
Cell Death Differ. 2008
PubMed ID: 18292781
p53 regulates FAK expression in human tumor cells.
Golubovskaya VM, Finch R, Kweh F, Massoll NA, Campbell-Thompson M, Wallace MR, Cance WG
Mol Carcinog. 2008
PubMed ID: 17999388
C-FLIP promotes the motility of cancer cells by activating FAK and ERK, and increasing MMP-9 expression.
Park D, Shim E, Kim Y, Kim YM, Lee H, Choe J, Kang D, Lee YS, Jeoung D
Mol Cells. 2008
PubMed ID: 18414015
Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration.
Carlucci A, Gedressi C, Lignitto L, Nezi L, Villa-Moruzzi E, Avvedimento EV, Gottesman M, Garbi C, Feliciello A
J Biol Chem. 2008
PubMed ID: 18223254
Involvement of focal adhesion kinase in cellular invasion of head and neck squamous cell carcinomas via regulation of MMP-2 expression.
Canel M, Secades P, Garzón-Arango M, Allonca E, Suarez C, Serrels A, Frame M, Brunton V, Chiara MD
Br J Cancer. 2008
PubMed ID: 18349846
Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.
Weis SM, Lim ST, Lutu-Fuga KM, Barnes LA, Chen XL, Göthert JR, Shen TL, Guan JL, Schlaepfer DD, Cheresh DA
J Cell Biol. 2008
PubMed ID: 18391070
Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2.
Pala D, Kapoor M, Woods A, Kennedy L, Liu S, Chen S, Bursell L, Lyons KM, Carter DE, Beier F, Leask A
J Biol Chem. 2008
PubMed ID: 18276598
Protein 600 is a microtubule/endoplasmic reticulum-associated protein in CNS neurons.
Shim SY, Wang J, Asada N, Neumayer G, Tran HC, Ishiguro K, Sanada K, Nakatani Y, Nguyen MD
J Neurosci. 2008
PubMed ID: 18385319
[Expressions and time-dependent changes of FAK and phospho-FAK during skin incised wound healing in mouse]
Yang DL, Guan DW, Zhang JJ
Fa Yi Xue Za Zhi. 2008
PubMed ID: 18605033
B1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms.
Bouchard V, Harnois C, Demers MJ, Thibodeau S, Laquerre V, Gauthier R, Vézina A, Noël D, Fujita N, Tsuruo T, Arguin M, Vachon PH
Apoptosis. 2008
PubMed ID: 18322799
A Novel Cas Family Member, HEPL, Regulates FAK and Cell Spreading.
Singh MK, Dadke D, Nicolas E, Serebriiskii IG, Apostolou S, Canutescu A, Egleston BL, Golemis EA
Mol Biol Cell. 2008
PubMed ID: 18256281
The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning.
Golubovskaya VM, Finch R, Zheng M, Kurenova EV, Cance WG
Biochem J. 2008
PubMed ID: 18215142
Concordant overexpression of p-FAK and p-ERK1/2 in extramammary Paget's disease.
Chen SY, Moroi Y, Urabe K, Takeuchi S, Kido M, Hayashida S, Uchi H, Uenotsuchi T, Tu YT, Furue M
Arch Dermatol Res. 2008
PubMed ID: 18210145
Src kinase regulates metalloproteinase-9 secretion induced by type IV collagen in MCF-7 human breast cancer cells.
Cortes-Reynosa P, Robledo T, Macias-Silva M, Wu SV, Salazar EP
Matrix Biol. 2008
PubMed ID: 18061419
Tac-beta1 inhibits FAK activation and Src signaling.
Berrier AL, Jones CW, LaFlamme SE
Biochem Biophys Res Commun. 2008
PubMed ID: 18198129
Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271.
Roberts WG, Ung E, Whalen P, Cooper B, Hulford C, Autry C, Richter D, Emerson E, Lin J, Kath J, Coleman K, Yao L, Martinez-Alsina L, Lorenzen M, Berliner M, Luzzio M, Patel N, Schmitt E, LaGreca S, Jani J, Wessel M, Marr E, Griffor M, Vajdos F
Cancer Res. 2008
PubMed ID: 18339875
FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts.
Iwanicki MP, Vomastek T, Tilghman RW, Martin KH, Banerjee J, Wedegaertner PB, Parsons JT
J Cell Sci. 2008
PubMed ID: 18303050
Regulation of stress granule dynamics by Grb7 and FAK signalling pathway.
Tsai NP, Ho PC, Wei LN
EMBO J. 2008
PubMed ID: 18273060
Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways.
Semaan N, Alsaleh G, Gottenberg JE, Wachsmann D, Sibilia J
J Immunol. 2008
PubMed ID: 18292575
FAK-mediated activation of ERK for eosinophil migration: a novel mechanism for infection-induced allergic inflammation.
Cheung PF, Wong CK, Ip WK, Lam CW
Int Immunol. 2008
PubMed ID: 18182379
The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics.
Ruusala A, Aspenström P
Mol Cell Biol. 2008
PubMed ID: 18086875
Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.
Hamamura K, Tsuji M, Ohkawa Y, Nakashima H, Miyazaki S, Urano T, Yamamoto N, Ueda M, Furukawa K, Furukawa K
Biochim Biophys Acta. 2008
PubMed ID: 18078823
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Focal adhesion targeting of v-Crk is essential for FAK phosphorylation and cell migration in mouse embryo fibroblasts deficient src family kinases or p130CAS.
Yeo MG, Sung BH, Oh HJ, Park ZY, Marcantonio EE, Song WK
J Cell Physiol. 2008
PubMed ID: 17786957
Alteration of focal adhesion kinase expression in eutopic endometrium of women with endometriosis.
Mu L, Zheng W, Wang L, Chen XJ, Zhang X, Yang JH
Fertil Steril. 2008
PubMed ID: 17543958
Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility.
Wu L, Bernard-Trifilo JA, Lim Y, Lim ST, Mitra SK, Uryu S, Chen M, Pallen CJ, Cheung NK, Mikolon D, Mielgo A, Stupack DG, Schlaepfer DD
Oncogene. 2008
PubMed ID: 17828307
Phosphorylation of focal adhesion kinase promotes extravasation of breast cancer cells.
Earley S, Plopper GE
Biochem Biophys Res Commun. 2008
PubMed ID: 18073135
Effects of FAK ablation on cerebellar foliation, Bergmann glia positioning and climbing fiber territory on Purkinje cells.
Watanabe F, Miyazaki T, Takeuchi T, Fukaya M, Nomura T, Noguchi S, Mori H, Sakimura K, Watanabe M, Mishina M
Eur J Neurosci. 2008
PubMed ID: 18279360
Structural basis for the interaction between focal adhesion kinase and CD4.
Garron ML, Arthos J, Guichou JF, McNally J, Cicala C, Arold ST
J Mol Biol. 2008
PubMed ID: 18078954
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.
Lim ST, Chen XL, Lim Y, Hanson DA, Vo TT, Howerton K, Larocque N, Fisher SJ, Schlaepfer DD, Ilic D
Mol Cell. 2008
PubMed ID: 18206965
Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus.
Kanasaki K, Kanda Y, Palmsten K, Tanjore H, Lee SB, Lebleu VS, Gattone VH, Kalluri R
Dev Biol. 2008
PubMed ID: 18082680
Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout.
Hitchcock IS, Fox NE, Prévost N, Sear K, Shattil SJ, Kaushansky K
Blood. 2008
PubMed ID: 17925492
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility.
Lim Y, Lim ST, Tomar A, Gardel M, Bernard-Trifilo JA, Chen XL, Uryu SA, Canete-Soler R, Zhai J, Lin H, Schlaepfer WW, Nalbant P, Bokoch G, Ilic D, Waterman-Storer C, Schlaepfer DD
J Cell Biol. 2008
PubMed ID: 18195107
Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis.
Mian MF, Kang C, Lee S, Choi JH, Bae SS, Kim SH, Kim YH, Ryu SH, Suh PG, Kim JS, Kim E
Chem Biol Interact. 2008
PubMed ID: 17888894
FAK expression regulation and therapeutic potential.
Li S, Hua ZC
Adv Cancer Res. 2008
PubMed ID: 19055942
FAAP, a novel murine protein, is involved in cell adhesion through regulating vinculin-paxillin association.
Hu J, Teng J, Ding N, He M, Sun Y, Yu AC, Chen J
Front Biosci. 2008
PubMed ID: 18508721
Focal adhesion kinase versus p53: apoptosis or survival?
Cance WG, Golubovskaya VM
Sci Signal. 2008
PubMed ID: 18493017
[Effect of gastrin on tyrosine phosphorylation of focal adhesion kinase in human gastric cancer cell line SGC7901]
Li D, Ding J, Wang XZ
Ai Zheng. 2008
PubMed ID: 18184462
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
Ballif BA, Carey GR, Sunyaev SR, Gygi SP
J Proteome Res. 2008
PubMed ID: 18034455
Src and FAK are key early signalling intermediates required for neurite growth in NGF-responsive adult DRG neurons.
Tucker BA, Rahimtula M, Mearow KM
Cell Signal. 2008
PubMed ID: 17999938
Spatial and temporal regulation of focal adhesion kinase activity in living cells.
Cai X, Lietha D, Ceccarelli DF, Karginov AV, Rajfur Z, Jacobson K, Hahn KM, Eck MJ, Schaller MD
Mol Cell Biol. 2008
PubMed ID: 17967873
TGFbeta-induced EMT requires focal adhesion kinase (FAK) signaling.
Cicchini C, Laudadio I, Citarella F, Corazzari M, Steindler C, Conigliaro A, Fantoni A, Amicone L, Tripodi M
Exp Cell Res. 2008
PubMed ID: 17949712
Focal adhesion kinase mediates defects in the force-dependent reinforcement of initial integrin-cytoskeleton linkages in metastatic colon cancer cell lines.
von Wichert G, Krndija D, Schmid H, von Wichert G, Haerter G, Adler G, Seufferlein T, Sheetz MP
Eur J Cell Biol. 2008
PubMed ID: 17904248
Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression.
Lahlou H, Sanguin-Gendreau V, Zuo D, Cardiff RD, McLean GW, Frame MC, Muller WJ
Proc Natl Acad Sci U S A. 2007
PubMed ID: 18056629
Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase.
Owen KA, Pixley FJ, Thomas KS, Vicente-Manzanares M, Ray BJ, Horwitz AF, Parsons JT, Beggs HE, Stanley ER, Bouton AH
J Cell Biol. 2007
PubMed ID: 18070912
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
Targeting focal adhesion kinase with small interfering RNA prevents and reverses load-induced cardiac hypertrophy in mice.
Clemente CF, Tornatore TF, Theizen TH, Deckmann AC, Pereira TC, Lopes-Cendes I, Souza JR, Franchini KG
Circ Res. 2007
PubMed ID: 17947798
MAP-kinase activity necessary for TGFbeta1-stimulated mesangial cell type I collagen expression requires adhesion-dependent phosphorylation of FAK tyrosine 397.
Hayashida T, Wu MH, Pierce A, Poncelet AC, Varga J, Schnaper HW
J Cell Sci. 2007
PubMed ID: 18032789
An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK.
Kamarajan P, Kapila YL
Apoptosis. 2007
PubMed ID: 17879163
Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma.
Halder J, Lin YG, Merritt WM, Spannuth WA, Nick AM, Honda T, Kamat AA, Han LY, Kim TJ, Lu C, Tari AM, Bornmann W, Fernandez A, Lopez-Berestein G, Sood AK
Cancer Res. 2007
PubMed ID: 18006843
Targeting of FAK Ser910 by ERK5 and PP1delta in non-stimulated and phorbol ester-stimulated cells.
Villa-Moruzzi E
Biochem J. 2007
PubMed ID: 17692050
SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis.
Le Y, Zhu BM, Harley B, Park SY, Kobayashi T, Manis JP, Luo HR, Yoshimura A, Hennighausen L, Silberstein LE
Immunity. 2007
PubMed ID: 18031698
Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth.
Hoshina N, Tezuka T, Yokoyama K, Kozuka-Hata H, Oyama M, Yamamoto T
Genes Cells. 2007
PubMed ID: 17986008
Focal adhesion kinase: an essential kinase in the regulation of cardiovascular functions.
Vadali K, Cai X, Schaller MD
IUBMB Life. 2007
PubMed ID: 17968709
Role of focal adhesion kinase (FAK) in renal ischaemia and reperfusion.
Holzapfel K, Neuhofer W, Bartels H, Fraek ML, Beck FX
Pflugers Arch. 2007
PubMed ID: 17549512
Disruption of FRNK expression by gene targeting of the intronic promoter within the focal adhesion kinase gene.
Hayasaka H, Martin KH, Hershey ED, Parsons JT
J Cell Biochem. 2007
PubMed ID: 17440961
Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland.
Nagy T, Wei H, Shen TL, Peng X, Liang CC, Gan B, Guan JL
J Biol Chem. 2007
PubMed ID: 17716968
[Expression of focal adhesion kinase in cardiac myocytes of hypertrophic ventricle]
Li ZY, Yi XP, Zhong L, Li FQ, Zhou WY, Cao WW, Zheng YX, Wang XH, Wang YN
Zhonghua Bing Li Xue Za Zhi. 2007
PubMed ID: 18194601
Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.
Holmes K, Roberts OL, Thomas AM, Cross MJ
Cell Signal. 2007
PubMed ID: 17658244
Role of c-Abl in directing metabolic versus mitogenic effects in insulin receptor signaling.
Frasca F, Pandini G, Malaguarnera R, Mandarino A, Messina RL, Sciacca L, Belfiore A, Vigneri R
J Biol Chem. 2007
PubMed ID: 17620332
Matrix metalloproteinase-2, caveolins, focal adhesion kinase and c-Kit in cells of the mouse myocardium.
Cho WJ, Chow AK, Schulz R, Daniel EE
J Cell Mol Med. 2007
PubMed ID: 17979883
Blockade of integrin beta3-FAK signaling pathway activated by osteopontin inhibits neointimal formation after balloon injury.
Han M, Wen JK, Zheng B, Liu Z, Chen Y
Cardiovasc Pathol. 2007
PubMed ID: 17868879
Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex.
Serrels B, Serrels A, Brunton VG, Holt M, McLean GW, Gray CH, Jones GE, Frame MC
Nat Cell Biol. 2007
PubMed ID: 17721515
Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways.
Bouchard V, Demers MJ, Thibodeau S, Laquerre V, Fujita N, Tsuruo T, Beaulieu JF, Gauthier R, Vézina A, Villeneuve L, Vachon PH
J Cell Physiol. 2007
PubMed ID: 17443665
Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis.
Plotkin LI, Manolagas SC, Bellido T
J Biol Chem. 2007
PubMed ID: 17581824
Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase.
Sekine Y, Tsuji S, Ikeda O, Sugiyma K, Oritani K, Shimoda K, Muromoto R, Ohbayashi N, Yoshimura A, Matsuda T
J Immunol. 2007
PubMed ID: 17675501
Interleukin 8 and cell migration to inflammatory sites: the regulation of focal adhesion kinase under conditions of migratory desensitization.
Cohen-Hillel E, Yron I, Meshel T, Ben-Baruch A
Isr Med Assoc J. 2007
PubMed ID: 17877062
EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution.
Schmidt M, Paes K, De Mazière A, Smyczek T, Yang S, Gray A, French D, Kasman I, Klumperman J, Rice DS, Ye W
Development. 2007
PubMed ID: 17626061
Extracellular signal-regulated kinase activation during renal ischemia/reperfusion mediates focal adhesion dissolution and renal injury.
Alderliesten M, de Graauw M, Oldenampsen J, Qin Y, Pont C, van Buren L, van de Water B
Am J Pathol. 2007
PubMed ID: 17620366
Stretch-induced MAP kinase activation in cardiac myocytes: differential regulation through beta1-integrin and focal adhesion kinase.
Lal H, Verma SK, Smith M, Guleria RS, Lu G, Foster DM, Dostal DE
J Mol Cell Cardiol. 2007
PubMed ID: 17583725
Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells.
Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE
Leukemia. 2007
PubMed ID: 17568820
Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment.
Hakim ZS, DiMichele LA, Doherty JT, Homeister JW, Beggs HE, Reichardt LF, Schwartz RJ, Brackhan J, Smithies O, Mack CP, Taylor JM
Mol Cell Biol. 2007
PubMed ID: 17526730
Inhibition of a specific N-glycosylation activity results in attenuation of breast carcinoma cell invasiveness-related phenotypes: inhibition of epidermal growth factor-induced dephosphorylation of focal adhesion kinase.
Guo HB, Randolph M, Pierce M
J Biol Chem. 2007
PubMed ID: 17537730
Reconciling the roles of FAK in osteoblast differentiation, osteoclast remodeling, and bone regeneration.
Kim JB, Leucht P, Luppen CA, Park YJ, Beggs HE, Damsky CH, Helms JA
Bone. 2007
PubMed ID: 17459803
Focal adhesion kinase and paxillin: novel regulators of brain sexual differentiation?
Speert DB, Konkle AT, Zup SL, Schwarz JM, Shiroor C, Taylor ME, McCarthy MM
Endocrinology. 2007
PubMed ID: 17412802
Tumor necrosis factor-alpha stimulates focal adhesion kinase activity required for mitogen-activated kinase-associated interleukin 6 expression.
Schlaepfer DD, Hou S, Lim ST, Tomar A, Yu H, Lim Y, Hanson DA, Uryu SA, Molina J, Mitra SK
J Biol Chem. 2007
PubMed ID: 17438336
Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinases.
Shi Q, Bao S, Song L, Wu Q, Bigner DD, Hjelmeland AB, Rich JN
Oncogene. 2007
PubMed ID: 17213807
Cleavage of focal adhesion kinase (FAK) is essential in adipocyte differentiation.
Li JJ, Xie D
Biochem Biophys Res Commun. 2007
PubMed ID: 17442274
Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization.
Ilic D, Mao-Qiang M, Crumrine D, Dolganov G, Larocque N, Xu P, Demerjian M, Brown BE, Lim ST, Ossovskaya V, Schlaepfer DD, Fisher SJ, Feingold KR, Elias PM, Mauro TM
Am J Pathol. 2007
PubMed ID: 17525272
FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.
Liu S, Xu SW, Kennedy L, Pala D, Chen Y, Eastwood M, Carter DE, Black CM, Abraham DJ, Leask A
Mol Biol Cell. 2007
PubMed ID: 17409352
FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway.
Thamilselvan V, Craig DH, Basson MD
FASEB J. 2007
PubMed ID: 17317726
Effect of cyclic stretch on beta1D-integrin expression and activation of FAK and RhoA.
Zhang SJ, Truskey GA, Kraus WE
Am J Physiol Cell Physiol. 2007
PubMed ID: 17267546
Load-induced focal adhesion mechanotransduction is altered with aging in the Fischer 344/NNiaHSd x Brown Norway/BiNia rat aorta.
Rice KM, Desai DH, Kinnard RS, Harris R, Wright GL, Blough ER
Biogerontology. 2007
PubMed ID: 17136425
Cellular characterization of a novel focal adhesion kinase inhibitor.
Slack-Davis JK, Martin KH, Tilghman RW, Iwanicki M, Ung EJ, Autry C, Luzzio MJ, Cooper B, Kath JC, Roberts WG, Parsons JT
J Biol Chem. 2007
PubMed ID: 17395594
Activation signal transduction by beta1 integrin in T cells from patients with systemic lupus erythematosus.
Nakayamada S, Saito K, Nakano K, Tanaka Y
Arthritis Rheum. 2007
PubMed ID: 17469136
Epidermal growth factor stimulates matrix metalloproteinase-9 expression and invasion in human follicular thyroid carcinoma cells through Focal adhesion kinase.
Rothhut B, Ghoneim C, Antonicelli F, Soula-Rothhut M
Biochimie. 2007
PubMed ID: 17397984
Development of the post-natal growth plate requires intraflagellar transport proteins.
Song B, Haycraft CJ, Seo HS, Yoder BK, Serra R
Dev Biol. 2007
PubMed ID: 17359961
Focal adhesion kinase regulates insulin resistance in skeletal muscle.
Bisht B, Goel HL, Dey CS
Diabetologia. 2007
PubMed ID: 17333113
Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells.
Jiang X, Sinnett-Smith J, Rozengurt E
Cell Signal. 2007
PubMed ID: 17240116
Src and focal adhesion kinase mediate mechanical strain-induced proliferation and ERK1/2 phosphorylation in human H441 pulmonary epithelial cells.
Chaturvedi LS, Marsh HM, Basson MD
Am J Physiol Cell Physiol. 2007
PubMed ID: 17215324
N-MYC regulates focal adhesion kinase expression in human neuroblastoma.
Beierle EA, Trujillo A, Nagaram A, Kurenova EV, Finch R, Ma X, Vella J, Cance WG, Golubovskaya VM
J Biol Chem. 2007
PubMed ID: 17327229
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks.
Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17389395
Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo.
Liu TJ, LaFortune T, Honda T, Ohmori O, Hatakeyama S, Meyer T, Jackson D, de Groot J, Yung WK
Mol Cancer Ther. 2007
PubMed ID: 17431114
Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK.
Liu DP, Wang Y, Koeffler HP, Xie D
Int J Oncol. 2007
PubMed ID: 17332925
Focal adhesion kinase is negatively regulated by phosphorylation at tyrosine 407.
Lim Y, Park H, Jeon J, Han I, Kim J, Jho EH, Oh ES
J Biol Chem. 2007
PubMed ID: 17303567
Focal adhesion kinase determines the fate of death or survival of cells in response to TNFalpha in the presence of actinomycin D.
Takahashi R, Sonoda Y, Ichikawa D, Yoshida N, Eriko AY, Tadashi K
Biochim Biophys Acta. 2007
PubMed ID: 17197095
Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts.
Horowitz JC, Rogers DS, Sharma V, Vittal R, White ES, Cui Z, Thannickal VJ
Cell Signal. 2007
PubMed ID: 17113264
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
A role for enhanced integrin and FAK expression in uremia-induced parathyroid hyperplasia.
Arcidiacono MV, Cozzolino M, Brancaccio D, Gallieni M, Lesma E, Carelli S, Gorio A, Di Giulio AM
J Nephrol. 2007
PubMed ID: 17514628
Polyethylenimine-complexed plasmid particles targeting focal adhesion kinase function as melanoma tumor therapeutics.
Li S, Dong W, Zong Y, Yin W, Jin G, Hu Q, Huang X, Jiang W, Hua ZC
Mol Ther. 2007
PubMed ID: 17285141
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H
Mol Cell Proteomics. 2007
PubMed ID: 17192257
Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics.
Schober M, Raghavan S, Nikolova M, Polak L, Pasolli HA, Beggs HE, Reichardt LF, Fuchs E
J Cell Biol. 2007
PubMed ID: 17325207
Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway.
Ng KT, Man K, Ho JW, Sun CK, Lee TK, Zhao Y, Lo CM, Poon RT, Fan ST
Int J Oncol. 2007
PubMed ID: 17203219
Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM
Mol Cell Proteomics. 2007
PubMed ID: 17114649
FAK phosphorylation at Ser-843 inhibits Tyr-397 phosphorylation, cell spreading and migration.
Jacamo R, Jiang X, Lunn JA, Rozengurt E
J Cell Physiol. 2007
PubMed ID: 17096371
Activation of FAK is necessary for the osteogenic differentiation of human mesenchymal stem cells on laminin-5.
Salasznyk RM, Klees RF, Boskey A, Plopper GE
J Cell Biochem. 2007
PubMed ID: 16927379
Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
FAK is required for axonal sorting by Schwann cells.
Grove M, Komiyama NH, Nave KA, Grant SG, Sherman DL, Brophy PJ
J Cell Biol. 2007
PubMed ID: 17242067
Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1.
Chaturvedi LS, Marsh HM, Shang X, Zheng Y, Basson MD
J Biol Chem. 2007
PubMed ID: 17088251
Activation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells.
Kallergi G, Agelaki S, Markomanolaki H, Georgoulias V, Stournaras C
Cell Physiol Biochem. 2007
PubMed ID: 17982280
Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension.
Umar S, Hessel M, Steendijk P, Bax W, Schutte C, Schalij M, van der Wall E, Atsma D, van der Laarse A
Pathol Res Pract. 2007
PubMed ID: 17913382
Phosphorylation of FAK, PI-3K, and impaired actin organization in CK-positive micrometastatic breast cancer cells.
Kallergi G, Mavroudis D, Georgoulias V, Stournaras C
Mol Med. 2007
PubMed ID: 17515959
Focal adhesion kinase (FAK) expression and activation during lens development.
Kokkinos MI, Brown HJ, de Iongh RU
Mol Vis. 2007
PubMed ID: 17417603
The effects of lidocaine and bupivacaine on protein expression of cleaved caspase 3 and tyrosine phosphorylation in the rat hippocampal slice.
Dahmani S, Rouelle D, Gressens P, Mantz J
Anesth Analg. 2007
PubMed ID: 17179255
FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX.
Chang F, Lemmon CA, Park D, Romer LH
Mol Biol Cell. 2007
PubMed ID: 17093062
Focal adhesion kinase signaling pathways regulate the osteogenic differentiation of human mesenchymal stem cells.
Salasznyk RM, Klees RF, Williams WA, Boskey A, Plopper GE
Exp Cell Res. 2007
PubMed ID: 17081517
Resealing of endothelial junctions by focal adhesion kinase.
Quadri SK, Bhattacharya J
Am J Physiol Lung Cell Mol Physiol. 2007
PubMed ID: 17012369
Gastrin-releasing peptide mediates its morphogenic properties in human colon cancer by upregulating intracellular adhesion protein-1 (ICAM-1) via focal adhesion kinase.
Taglia L, Matusiak D, Matkowskyj KA, Benya RV
Am J Physiol Gastrointest Liver Physiol. 2007
PubMed ID: 16920698
Enhanced expression of cholecystokinin-2 receptor promotes the progression of colon cancer through activation of focal adhesion kinase.
Yu HG, Tong SL, Ding YM, Ding J, Fang XM, Zhang XF, Liu ZJ, Zhou YH, Liu QS, Luo HS, Yu JP
Int J Cancer. 2006
PubMed ID: 16998832
Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth.
Gan B, Yoo Y, Guan JL
J Biol Chem. 2006
PubMed ID: 17043358
Cancer/testis antigen cancer-associated gene (CAGE) promotes motility of cancer cells through activation of focal adhesion kinase (FAK).
Shim H, Lee H, Jeoung D
Biotechnol Lett. 2006
PubMed ID: 17028776
Thy-1, via its GPI anchor, modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, in response to thrombospondin-1/hep I.
Rege TA, Pallero MA, Gomez C, Grenett HE, Murphy-Ullrich JE, Hagood JS
Exp Cell Res. 2006
PubMed ID: 17027000
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
[Expression and clinical significance of focal adhesion kinase in oral squamous cell carcinoma]
He ZX, He HW, Wang D, Fang MX
Sichuan Da Xue Xue Bao Yi Xue Ban. 2006
PubMed ID: 17236584
Invasion of host cells by Salmonella typhimurium requires focal adhesion kinase and p130Cas.
Shi J, Casanova JE
Mol Biol Cell. 2006
PubMed ID: 16914515
Tissue inhibitor of metalloproteinases 3 regulates extracellular matrix--cell signaling during bronchiole branching morphogenesis.
Gill SE, Pape MC, Leco KJ
Dev Biol. 2006
PubMed ID: 16890932
Dystrophin Dp71f associates with the beta1-integrin adhesion complex to modulate PC12 cell adhesion.
Cerna J, Cerecedo D, Ortega A, García-Sierra F, Centeno F, Garrido E, Mornet D, Cisneros B
J Mol Biol. 2006
PubMed ID: 16935300
Integrin-regulated FAK-Src signaling in normal and cancer cells.
Mitra SK, Schlaepfer DD
Curr Opin Cell Biol. 2006
PubMed ID: 16919435
Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells.
van Nimwegen MJ, Huigsloot M, Camier A, Tijdens IB, van de Water B
Mol Pharmacol. 2006
PubMed ID: 16825486
Primary role of the serotonergic midline system in synchronized spontaneous activity during development of the embryonic mouse hindbrain.
Hunt PN, Gust J, McCabe AK, Bosma MM
J Neurobiol. 2006
PubMed ID: 16902991
Myocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy.
DiMichele LA, Doherty JT, Rojas M, Beggs HE, Reichardt LF, Mack CP, Taylor JM
Circ Res. 2006
PubMed ID: 16902179
Expression of FAK-related non-kinase (FRNK) coincides with morphological change in the early stage of cell adhesion.
Nagoshi Y, Yamamoto G, Irie T, Tachikawa T
Med Mol Morphol. 2006
PubMed ID: 16998626
FAK-related nonkinase attenuates hypertrophy induced by angiotensin-II in cultured neonatal rat cardiac myocytes.
Qin J, Liu ZX
Acta Pharmacol Sin. 2006
PubMed ID: 16923336
Focal adhesion kinase protein levels in gut epithelial motility.
Basson MD, Sanders MA, Gomez R, Hatfield J, Vanderheide R, Thamilselvan V, Zhang J, Walsh MF
Am J Physiol Gastrointest Liver Physiol. 2006
PubMed ID: 16899713
Up-regulation of focal adhesion kinase in non-small cell lung cancer.
Carelli S, Zadra G, Vaira V, Falleni M, Bottiglieri L, Nosotti M, Di Giulio AM, Gorio A, Bosari S
Lung Cancer. 2006
PubMed ID: 16842883
Mechano-chemical signaling in F9 cells.
Klemm AH, Suchodolski K, Goldmann WH
Cell Biol Int. 2006
PubMed ID: 16798023
Age-related changes in focal adhesions lead to altered cell behavior in tendon fibroblasts.
Arnesen SM, Lawson MA
Mech Ageing Dev. 2006
PubMed ID: 16780927
A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.
Li T, Santockyte R, Shen RF, Tekle E, Wang G, Yang DC, Chock PB
Arch Biochem Biophys. 2006
PubMed ID: 16620772
Role of focal adhesion kinase and phosphatidylinositol 3'-kinase in integrin fibronectin receptor-mediated, matrix metalloproteinase-1-dependent invasion by metastatic prostate cancer cells.
Zeng ZZ, Jia Y, Hahn NJ, Markwart SM, Rockwood KF, Livant DL
Cancer Res. 2006
PubMed ID: 16912186
Phosphorylation of focal adhesion kinase (FAK) on Ser732 is induced by rho-dependent kinase and is essential for proline-rich tyrosine kinase-2-mediated phosphorylation of FAK on Tyr407 in response to vascular endothelial growth factor.
Le Boeuf F, Houle F, Sussman M, Huot J
Mol Biol Cell. 2006
PubMed ID: 16760434
Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model.
Mitra SK, Lim ST, Chi A, Schlaepfer DD
Oncogene. 2006
PubMed ID: 16547501
An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling.
Pirone DM, Liu WF, Ruiz SA, Gao L, Raghavan S, Lemmon CA, Romer LH, Chen CS
J Cell Biol. 2006
PubMed ID: 16847103
Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikis.
Rafiq K, Kolpakov MA, Abdelfettah M, Streblow DN, Hassid A, Dell'Italia LJ, Sabri A
J Biol Chem. 2006
PubMed ID: 16690621
Reduced expression of focal adhesion kinase disrupts insulin action in skeletal muscle cells.
Huang D, Khoe M, Ilic D, Bryer-Ash M
Endocrinology. 2006
PubMed ID: 16574795
C/EBPalpha inactivation in FAK-overexpressed HL-60 cells impairs cell differentiation.
Hashimoto K, Sonoda Y, Yamakado M, Funakoshi-Tago M, Yoshida N, Rokudai A, Aizu-Yokota E, Kasahara T
Cell Signal. 2006
PubMed ID: 16226872
Focal adhesion kinase controls cellular levels of p27/Kip1 and p21/Cip1 through Skp2-dependent and -independent mechanisms.
Bryant P, Zheng Q, Pumiglia K
Mol Cell Biol. 2006
PubMed ID: 16705171
Nuclear compartmentalization of FAK and FRNK in cardiac myocytes.
Yi XP, Zhou J, Huber L, Qu J, Wang X, Gerdes AM, Li F
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16373587
FAK-dependent regulation of myofibroblast differentiation.
Greenberg RS, Bernstein AM, Benezra M, Gelman IH, Taliana L, Masur SK
FASEB J. 2006
PubMed ID: 16585062
p130Cas: a versatile scaffold in signaling networks.
Defilippi P, Di Stefano P, Cabodi S
Trends Cell Biol. 2006
PubMed ID: 16581250
Focal adhesion kinase is essential for costamerogenesis in cultured skeletal muscle cells.
Quach NL, Rando TA
Dev Biol. 2006
PubMed ID: 16533505
Weak expression of focal adhesion kinase (pp125FAK) in patients with cervical cancer is associated with poor disease outcome.
Gabriel B, zur Hausen A, Stickeler E, Dietz C, Gitsch G, Fischer DC, Bouda J, Tempfer C, Hasenburg A
Clin Cancer Res. 2006
PubMed ID: 16638855
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer.
Planas-Silva MD, Bruggeman RD, Grenko RT, Stanley Smith J
Biochem Biophys Res Commun. 2006
PubMed ID: 16412380
Role of Src-specific phosphorylation site on focal adhesion kinase for senescence-associated apoptosis resistance.
Ryu SJ, Cho KA, Oh YS, Park SC
Apoptosis. 2006
PubMed ID: 16523241
Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer.
Ballestrem C, Erez N, Kirchner J, Kam Z, Bershadsky A, Geiger B
J Cell Sci. 2006
PubMed ID: 16478788
Activation of the lutropin/choriogonadotropin receptor in MA-10 cells leads to the tyrosine phosphorylation of the focal adhesion kinase by a pathway that involves Src family kinases.
Mizutani T, Shiraishi K, Welsh T, Ascoli M
Mol Endocrinol. 2006
PubMed ID: 16293639
Neurofibromin binds to caveolin-1 and regulates ras, FAK, and Akt.
Boyanapalli M, Lahoud OB, Messiaen L, Kim B, Anderle de Sylor MS, Duckett SJ, Somara S, Mikol DD
Biochem Biophys Res Commun. 2006
PubMed ID: 16405917
Hair cycle and wound healing in mice with a keratinocyte-restricted deletion of FAK.
Essayem S, Kovacic-Milivojevic B, Baumbusch C, McDonagh S, Dolganov G, Howerton K, Larocque N, Mauro T, Ramirez A, Ramos DM, Fisher SJ, Jorcano JL, Beggs HE, Reichardt LF, Ilic D
Oncogene. 2006
PubMed ID: 16247468
Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells.
Garces CA, Kurenova EV, Golubovskaya VM, Cance WG
Cancer Res. 2006
PubMed ID: 16452200
Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability.
Holinstat M, Knezevic N, Broman M, Samarel AM, Malik AB, Mehta D
J Biol Chem. 2006
PubMed ID: 16308318
EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation.
Moeller ML, Shi Y, Reichardt LF, Ethell IM
J Biol Chem. 2006
PubMed ID: 16298995
Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration.
Zhang Z, Lin SY, Neel BG, Haimovich B
J Biol Chem. 2006
PubMed ID: 16291744
DNA sequence and analysis of human chromosome 8.
Nusbaum C, Mikkelsen TS, Zody MC, Asakawa S, Taudien S, Garber M, Kodira CD, Schueler MG, Shimizu A, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Allen NR, Anderson S, Asakawa T, Blechschmidt K, Bloom T, Borowsky ML, Butler J, Cook A, Corum B, DeArellano K, DeCaprio D, Dooley KT, Dorris L, Engels R, Glöckner G, Hafez N, Hagopian DS, Hall JL, Ishikawa SK, Jaffe DB, Kamat A, Kudoh J, Lehmann R, Lokitsang T, Macdonald P, Major JE, Matthews CD, Mauceli E, Menzel U, Mihalev AH, Minoshima S, Murayama Y, Naylor JW, Nicol R, Nguyen C, O'Leary SB, O'Neill K, Parker SC, Polley A, Raymond CK, Reichwald K, Rodriguez J, Sasaki T, Schilhabel M, Siddiqui R, Smith CL, Sneddon TP, Talamas JA, Tenzin P, Topham K, Venkataraman V, Wen G, Yamazaki S, Young SK, Zeng Q, Zimmer AR, Rosenthal A, Birren BW, Platzer M, Shimizu N, Lander ES
Nature. 2006
PubMed ID: 16421571
CXCL8-induced FAK phosphorylation via CXCR1 and CXCR2: cytoskeleton- and integrin-related mechanisms converge with FAK regulatory pathways in a receptor-specific manner.
Cohen-Hillel E, Yron I, Meshel T, Soria G, Attal H, Ben-Baruch A
Cytokine. 2006
PubMed ID: 16406804
Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation.
Braren R, Hu H, Kim YH, Beggs HE, Reichardt LF, Wang R
J Cell Biol. 2006
PubMed ID: 16391003
Organization and post-transcriptional processing of focal adhesion kinase gene.
Corsi JM, Rouer E, Girault JA, Enslen H
BMC Genomics. 2006
PubMed ID: 16889663
Homozygous mutation of focal adhesion kinase in embryonic stem cell derived neurons: normal electrophysiological and morphological properties in vitro.
Charlesworth P, Komiyama NH, Grant SG
BMC Neurosci. 2006
PubMed ID: 16768796
Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice.
Peng X, Kraus MS, Wei H, Shen TL, Pariaut R, Alcaraz A, Ji G, Cheng L, Yang Q, Kotlikoff MI, Chen J, Chien K, Gu H, Guan JL
J Clin Invest. 2006
PubMed ID: 16374517
FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5.
Li W, Aurandt J, Jürgensen C, Jürgense C, Rao Y, Guan KL
J Cell Sci. 2006
PubMed ID: 16371650
Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA.
Tsutsumi R, Takahashi A, Azuma T, Higashi H, Hatakeyama M
Mol Cell Biol. 2006
PubMed ID: 16354697
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Role of focal adhesion kinase in flow-induced dilation of coronary arterioles.
Koshida R, Rocic P, Saito S, Kiyooka T, Zhang C, Chilian WM
Arterioscler Thromb Vasc Biol. 2005
PubMed ID: 16195476
Regulation of cardiac volume-sensitive chloride channel by focal adhesion kinase and Src kinase.
Walsh KB, Zhang J
Am J Physiol Heart Circ Physiol. 2005
PubMed ID: 16040720
Focal adhesion kinase signaling regulates cardiogenesis of embryonic stem cells.
Hakuno D, Takahashi T, Lammerding J, Lee RT
J Biol Chem. 2005
PubMed ID: 16157602
FAK and PYK2 interact with SAP90/PSD-95-Associated Protein-3.
Bongiorno-Borbone L, Kadaré G, Benfenati F, Girault JA
Biochem Biophys Res Commun. 2005
PubMed ID: 16202977
JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration.
Takino T, Nakada M, Miyamori H, Watanabe Y, Sato T, Gantulga D, Yoshioka K, Yamada KM, Sato H
J Biol Chem. 2005
PubMed ID: 16141199
FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion.
Benlimame N, He Q, Jie S, Xiao D, Xu YJ, Loignon M, Schlaepfer DD, Alaoui-Jamali MA
J Cell Biol. 2005
PubMed ID: 16275754
Dual function of focal adhesion kinase in regulating integrin-induced MMP-2 and MMP-9 release by human T lymphoid cells.
Segarra M, Vilardell C, Matsumoto K, Esparza J, Lozano E, Serra-Pages C, Urbano-Márquez A, Yamada KM, Cid MC
FASEB J. 2005
PubMed ID: 16260653
In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation.
Riemenschneider MJ, Mueller W, Betensky RA, Mohapatra G, Louis DN
Am J Pathol. 2005
PubMed ID: 16251422
Effects of dexmedetomidine on hippocampal focal adhesion kinase tyrosine phosphorylation in physiologic and ischemic conditions.
Dahmani S, Rouelle D, Gressens P, Mantz J
Anesthesiology. 2005
PubMed ID: 16249671
Neonatal cerebral hypoxia-ischemia: involvement of FAK-dependent pathway.
Zalewska T, Makarewicz D, Janik B, Ziemka-Nałecz M
Int J Dev Neurosci. 2005
PubMed ID: 16095866
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration.
Bianchi M, De Lucchini S, Marin O, Turner DL, Hanks SK, Villa-Moruzzi E
Biochem J. 2005
PubMed ID: 15975092
Focal adhesion kinase and Src phosphorylations in HGF-induced proliferation and invasion of human cholangiocarcinoma cell line, HuCCA-1.
Pongchairerk U, Guan JL, Leardkamolkarn V
World J Gastroenterol. 2005
PubMed ID: 16270396
Increased tyrosine phosphorylation of platelet proteins including pp125(FAK) suggests endogenous activation and aggregation in pulmonary hypertension.
Maeda NY, Bydlowski SP, Lopes AA
Clin Appl Thromb Hemost. 2005
PubMed ID: 16244766
Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397.
Hamadi A, Bouali M, Dontenwill M, Stoeckel H, Takeda K, Rondé P
J Cell Sci. 2005
PubMed ID: 16159962
RhoA/ROCK signaling is critical to FAK activation by cyclic stretch in cardiac myocytes.
Torsoni AS, Marin TM, Velloso LA, Franchini KG
Am J Physiol Heart Circ Physiol. 2005
PubMed ID: 15923313
Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma.
Niwa Y, Kanda H, Shikauchi Y, Saiura A, Matsubara K, Kitagawa T, Yamamoto J, Kubo T, Yoshikawa H
Oncogene. 2005
PubMed ID: 16007195
Specific induction of pp125 focal adhesion kinase in human breast cancer.
Watermann DO, Gabriel B, Jäger M, Orlowska-Volk M, Hasenburg A, zur Hausen A, Gitsch G, Stickeler E
Br J Cancer. 2005
PubMed ID: 16136050
Absence of Fyn and Src causes a reeler-like phenotype.
Kuo G, Arnaud L, Kronstad-O'Brien P, Cooper JA
J Neurosci. 2005
PubMed ID: 16162939
A truncated FAK lacking the FERM domain displays high catalytic activity but retains responsiveness to adhesion-mediated signals.
Jácamo RO, Rozengurt E
Biochem Biophys Res Commun. 2005
PubMed ID: 16039608
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Focal adhesion kinase plays a pivotal role in herpes simplex virus entry.
Cheshenko N, Liu W, Satlin LM, Herold BC
J Biol Chem. 2005
PubMed ID: 15994312
alpha(v)beta3-integrin-dependent activation of focal adhesion kinase mediates NF-kappaB activation and motogenic activity by HIV-1 Tat in endothelial cells.
Urbinati C, Bugatti A, Giacca M, Schlaepfer D, Presta M, Rusnati M
J Cell Sci. 2005
PubMed ID: 16105876
Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.
Brown MC, Cary LA, Jamieson JS, Cooper JA, Turner CE
Mol Biol Cell. 2005
PubMed ID: 16000375
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.
Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM
Mol Cell Proteomics. 2005
PubMed ID: 15951569
Differentiation of C2C12 myoblasts is critically regulated by FAK signaling.
Clemente CF, Corat MA, Saad ST, Franchini KG
Am J Physiol Regul Integr Comp Physiol. 2005
PubMed ID: 15890789
Cilia and Hedgehog responsiveness in the mouse.
Huangfu D, Anderson KV
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16061793
Direct phosphorylation of proliferative and survival pathway proteins by RET.
Panta GR, Du L, Nwariaku FE, Kim LT
Surgery. 2005
PubMed ID: 16153436
FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation.
Wu X, Gan B, Yoo Y, Guan JL
Dev Cell. 2005
PubMed ID: 16054026
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53.
Golubovskaya VM, Finch R, Cance WG
J Biol Chem. 2005
PubMed ID: 15855171
G protein-coupled receptor activation rapidly stimulates focal adhesion kinase phosphorylation at Ser-843. Mediation by Ca2+, calmodulin, and Ca2+/calmodulin-dependent kinase II.
Fan RS, Jácamo RO, Jiang X, Sinnett-Smith J, Rozengurt E
J Biol Chem. 2005
PubMed ID: 15845548
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis.
Shen TL, Park AY, Alcaraz A, Peng X, Jang I, Koni P, Flavell RA, Gu H, Guan JL
J Cell Biol. 2005
PubMed ID: 15967814
Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells.
Tilghman RW, Slack-Davis JK, Sergina N, Martin KH, Iwanicki M, Hershey ED, Beggs HE, Reichardt LF, Parsons JT
J Cell Sci. 2005
PubMed ID: 15914540
Targeting of alpha(v) integrins interferes with FAK activation and smooth muscle cell migration and invasion.
Varadarajulu J, Laser M, Hupp M, Wu R, Hauck CR
Biochem Biophys Res Commun. 2005
PubMed ID: 15850774
Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation.
van Nimwegen MJ, Verkoeijen S, van Buren L, Burg D, van de Water B
Cancer Res. 2005
PubMed ID: 15930288
Cross talk between MyD88 and focal adhesion kinase pathways.
Zeisel MB, Druet VA, Sibilia J, Klein JP, Quesniaux V, Wachsmann D
J Immunol. 2005
PubMed ID: 15905587
Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase.
Ezratty EJ, Partridge MA, Gundersen GG
Nat Cell Biol. 2005
PubMed ID: 15895076
Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli.
Li N, Zhang Y, Naylor MJ, Schatzmann F, Maurer F, Wintermantel T, Schuetz G, Mueller U, Streuli CH, Hynes NE
EMBO J. 2005
PubMed ID: 15889143
Linkage analysis of the genetic determinants of T-cell IL-4 secretion, and identification of Flj20274 as a putative candidate gene.
Choi P, Xanthaki D, Rose SJ, Haywood M, Reiser H, Morley BJ
Genes Immun. 2005
PubMed ID: 15815685
JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53.
Tafolla E, Wang S, Wong B, Leong J, Kapila YL
J Biol Chem. 2005
PubMed ID: 15778501
Enhanced v-Src-induced oncogenic transformation in the absence of focal adhesion kinase is mediated by phosphatidylinositol 3-kinase.
Moissoglu K, Sachdev S, Gelman IH
Biochem Biophys Res Commun. 2005
PubMed ID: 15809050
Focal adhesion kinase is required for bombesin-induced prostate cancer cell motility.
Lacoste J, Aprikian AG, Chevalier S
Mol Cell Endocrinol. 2005
PubMed ID: 15866427
Reciprocally interacting domains of protein phosphatase 1 and focal adhesion kinase.
Bianchi M, De Lucchini S, Vietri M, Villa-Moruzzi E
Mol Cell Biochem. 2005
PubMed ID: 16010975
Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics.
Crockett DK, Fillmore GC, Elenitoba-Johnson KS, Lim MS
Proteomics. 2005
PubMed ID: 15717329
Sodium arsenite exposure alters cell migration, focal adhesion localization and decreases tyrosine phosphorylation of focal adhesion kinase in H9C2 myoblasts.
Yancy SL, Shelden EA, Gilmont RR, Welsh MJ
Toxicol Sci. 2005
PubMed ID: 15537746
Loss of Rb-E2F repression results in caspase-8-mediated apoptosis through inactivation of focal adhesion kinase.
Lieman JH, Worley LA, Harbour JW
J Biol Chem. 2005
PubMed ID: 15640164
Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation.
Cohen LA, Guan JL
J Biol Chem. 2005
PubMed ID: 15611137
Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning.
Nikolopoulos SN, Giancotti FG
Cell Cycle. 2005
PubMed ID: 15725728
Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
Sigurdsson S, Nordmark G, Göring HH, Lindroos K, Wiman AC, Sturfelt G, Jönsen A, Rantapää-Dahlqvist S, Möller B, Kere J, Koskenmies S, Widén E, Eloranta ML, Julkunen H, Kristjansdottir H, Steinsson K, Alm G, Rönnblom L, Syvänen AC
Am J Hum Genet. 2005
PubMed ID: 15657875
Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes.
Wong CH, Xia W, Lee NP, Mruk DD, Lee WM, Cheng CY
Endocrinology. 2005
PubMed ID: 15591141
The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration.
Pratt SJ, Epple H, Ward M, Feng Y, Braga VM, Longmore GD
J Cell Biol. 2005
PubMed ID: 15728191
Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells.
Montiel M, de la Blanca EP, Jiménez E
Biochem Biophys Res Commun. 2005
PubMed ID: 15652490
p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain.
Ding Q, Grammer JR, Nelson MA, Guan JL, Stewart JE, Gladson CL
J Biol Chem. 2005
PubMed ID: 15557280
Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids.
von Sengbusch A, Gassmann P, Fisch KM, Enns A, Nicolson GL, Haier J
Am J Pathol. 2005
PubMed ID: 15681841
Differential expression of protease activated receptor 1 (Par1) and pY397FAK in benign and malignant human ovarian tissue samples.
Grisaru-Granovsky S, Salah Z, Maoz M, Pruss D, Beller U, Bar-Shavit R
Int J Cancer. 2005
PubMed ID: 15455382
The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.
Continolo S, Baruzzi A, Majeed M, Caveggion E, Fumagalli L, Lowell CA, Berton G
Exp Cell Res. 2005
PubMed ID: 15561106
Targeting to C-terminal myosin heavy chain may explain mechanotransduction involving focal adhesion kinase in cardiac myocytes.
Fonseca PM, Inoue RY, Kobarg CB, Crosara-Alberto DP, Kobarg J, Franchini KG
Circ Res. 2005
PubMed ID: 15576648
High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization.
Naylor TL, Greshock J, Wang Y, Colligon T, Yu QC, Clemmer V, Zaks TZ, Weber BL
Breast Cancer Res. 2005
PubMed ID: 16457699
Focal adhesion kinase is activated in invading fibrosarcoma cells and regulates metastasis.
Hanada M, Tanaka K, Matsumoto Y, Nakatani F, Sakimura R, Matsunobu T, Li X, Okada T, Nakamura T, Takasaki M, Iwamoto Y
Clin Exp Metastasis. 2005
PubMed ID: 16320111
Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and tumor growth.
Chang LC, Huang CH, Cheng CH, Chen BH, Chen HC
J Biomed Sci. 2005
PubMed ID: 16132110
High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome.
Schmitz KJ, Grabellus F, Callies R, Otterbach F, Wohlschlaeger J, Levkau B, Kimmig R, Schmid KW, Baba HA
Breast Cancer Res. 2005
PubMed ID: 15743500
Tagging genes with cassette-exchange sites.
Cobellis G, Nicolaus G, Iovino M, Romito A, Marra E, Barbarisi M, Sardiello M, Di Giorgio FP, Iovino N, Zollo M, Ballabio A, Cortese R
Nucleic Acids Res. 2005
PubMed ID: 15741177
The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1.
Ha HY, Cho IH, Lee KW, Lee KW, Song JY, Kim KS, Yu YM, Lee JK, Song JS, Yang SD, Shin HS, Han PL
Dev Biol. 2005
PubMed ID: 15572149
Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.
McLean GW, Komiyama NH, Serrels B, Asano H, Reynolds L, Conti F, Hodivala-Dilke K, Metzger D, Chambon P, Grant SG, Frame MC
Genes Dev. 2004
PubMed ID: 15601818
RET signals through focal adhesion kinase in medullary thyroid cancer cells.
Panta GR, Nwariaku F, Kim LT
Surgery. 2004
PubMed ID: 15657578
RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane.
Sandilands E, Cans C, Fincham VJ, Brunton VG, Mellor H, Prendergast GC, Norman JC, Superti-Furga G, Frame MC
Dev Cell. 2004
PubMed ID: 15572128
Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice.
Peng X, Ueda H, Zhou H, Stokol T, Shen TL, Alcaraz A, Nagy T, Vassalli JD, Guan JL
Cardiovasc Res. 2004
PubMed ID: 15537495
Focal adhesion kinase overexpression in endometrial neoplasia.
Livasy CA, Moore D, Cance WG, Lininger RA
Appl Immunohistochem Mol Morphol. 2004
PubMed ID: 15536334
Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly.
Orr AW, Pallero MA, Xiong WC, Murphy-Ullrich JE
J Biol Chem. 2004
PubMed ID: 15371459
HIV-1 Tat-mediated effects on focal adhesion assembly and permeability in brain microvascular endothelial cells.
Avraham HK, Jiang S, Lee TH, Prakash O, Avraham S
J Immunol. 2004
PubMed ID: 15528360
Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase.
Zhang Y, Lu H, Dazin P, Kapila Y
J Biol Chem. 2004
PubMed ID: 15331608
Functional analysis of focal adhesion kinase (FAK) reduction by small inhibitory RNAs.
Han EK, Mcgonigal T, Wang J, Giranda VL, Luo Y
Anticancer Res. 2004
PubMed ID: 15736429
Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis.
Lightfoot HM, Lark A, Livasy CA, Moore DT, Cowan D, Dressler L, Craven RJ, Cance WG
Breast Cancer Res Treat. 2004
PubMed ID: 15564794
Activation of FAK and Src are receptor-proximal events required for netrin signaling.
Li W, Lee J, Vikis HG, Lee SH, Liu G, Aurandt J, Shen TL, Fearon ER, Guan JL, Han M, Rao Y, Hong K, Guan KL
Nat Neurosci. 2004
PubMed ID: 15494734
Focal adhesion kinase in netrin-1 signaling.
Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC
Nat Neurosci. 2004
PubMed ID: 15494733
Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction.
Liu G, Beggs H, Jürgensen C, Park HT, Tang H, Gorski J, Jones KR, Reichardt LF, Wu J, Rao Y
Nat Neurosci. 2004
PubMed ID: 15494732
Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis.
Ishibe S, Joly D, Liu ZX, Cantley LG
Mol Cell. 2004
PubMed ID: 15494312
Relationship between focal adhesion kinase and hepatic stellate cell proliferation during rat hepatic fibrogenesis.
Jiang HQ, Zhang XL, Liu L, Yang CC
World J Gastroenterol. 2004
PubMed ID: 15378782
Down-regulation of procaspase-8 expression by focal adhesion kinase protects HL-60 cells from TRAIL-induced apoptosis.
Tamagiku Y, Sonoda Y, Kunisawa M, Ichikawa D, Murakami Y, Aizu-Yokota E, Kasahara T
Biochem Biophys Res Commun. 2004
PubMed ID: 15369772
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Cyclic mechanical strain inhibits skeletal myogenesis through activation of focal adhesion kinase, Rac-1 GTPase, and NF-kappaB transcription factor.
Kumar A, Murphy R, Robinson P, Wei L, Boriek AM
FASEB J. 2004
PubMed ID: 15466361
Control of axonal branching and synapse formation by focal adhesion kinase.
Rico B, Beggs HE, Schahin-Reed D, Kimes N, Schmidt A, Reichardt LF
Nat Neurosci. 2004
PubMed ID: 15378065
Dopamine in vivo inhibits VEGF-induced phosphorylation of VEGFR-2, MAPK, and focal adhesion kinase in endothelial cells.
Sarkar C, Chakroborty D, Mitra RB, Banerjee S, Dasgupta PS, Basu S
Am J Physiol Heart Circ Physiol. 2004
PubMed ID: 15371263
Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities.
Le Boeuf F, Houle F, Huot J
J Biol Chem. 2004
PubMed ID: 15247219
Focal adhesion kinase (FAK)-dependent regulation of S-phase kinase-associated protein-2 (Skp-2) stability. A novel mechanism regulating smooth muscle cell proliferation.
Bond M, Sala-Newby GB, Newby AC
J Biol Chem. 2004
PubMed ID: 15208331
SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling.
Westhoff MA, Serrels B, Fincham VJ, Frame MC, Carragher NO
Mol Cell Biol. 2004
PubMed ID: 15340073
beta1-Integrins induce phosphorylation of Akt on serine 473 independently of focal adhesion kinase and Src family kinases.
Velling T, Nilsson S, Stefansson A, Johansson S
EMBO Rep. 2004
PubMed ID: 15309026
Genomic analysis of mouse retinal development.
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
PLoS Biol. 2004
PubMed ID: 15226823
Focal adhesion kinase mediates endothelin-induced cyclin D3 expression in rat cultured astrocytes.
Koyama Y, Yoshioka Y, Shinde M, Matsuda T, Baba A
J Neurochem. 2004
PubMed ID: 15287896
Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.
Verma-Kurvari S, Parada LF
Dev Dyn. 2004
PubMed ID: 15254900
Thiopental and isoflurane attenuate the decrease in hippocampal phosphorylated Focal Adhesion Kinase (pp125FAK) content induced by oxygen-glucose deprivation.
Dahmani S, Tesnière A, Rouelle D, Desmonts JM, Mantz J
Br J Anaesth. 2004
PubMed ID: 15194624
Decreased expression of beta1-integrin and focal adhesion kinase in epithelial cells may initiate involution of mammary glands.
McMahon CD, Farr VC, Singh K, Wheeler TT, Davis SR
J Cell Physiol. 2004
PubMed ID: 15174102
Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway.
Xia H, Nho RS, Kahm J, Kleidon J, Henke CA
J Biol Chem. 2004
PubMed ID: 15166238
Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation.
Boutahar N, Guignandon A, Vico L, Lafage-Proust MH
J Biol Chem. 2004
PubMed ID: 15096502
Sequential activation of RhoA and FAK/paxillin leads to ATP release and actin reorganization in human endothelium.
Hirakawa M, Oike M, Karashima Y, Ito Y
J Physiol. 2004
PubMed ID: 15155793
Phosphorylation of focal adhesion kinase at tyrosine 861 is crucial for Ras transformation of fibroblasts.
Lim Y, Han I, Jeon J, Park H, Bahk YY, Oh ES
J Biol Chem. 2004
PubMed ID: 15123632
Calcium rises locally trigger focal adhesion disassembly and enhance residency of focal adhesion kinase at focal adhesions.
Giannone G, Rondé P, Gaire M, Beaudouin J, Haiech J, Ellenberg J, Takeda K
J Biol Chem. 2004
PubMed ID: 15102844
Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines.
Zhang L, Yu Q, He J, Zha X
Mol Cell Biochem. 2004
PubMed ID: 15532706
Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms.
Yang J, Price MA, Neudauer CL, Wilson C, Ferrone S, Xia H, Iida J, Simpson MA, McCarthy JB
J Cell Biol. 2004
PubMed ID: 15210734
Differential regulation of FAK and PYK2 tyrosine phosphorylation after electroconvulsive shock in the rat brain.
Kang UG, Jun SJ, Yoon SC, Jeon S, Park JB, Chung CK, Juhnn YS, Kim YS
Neurosci Lett. 2004
PubMed ID: 15172101
Nerve growth factor (NGF) induces a rapid and sustained downregulation of the focal adhesion kinase (FAK).
Gatti A
Cell Mol Neurobiol. 2004
PubMed ID: 15206825
Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites.
Golubovskaya V, Kaur A, Cance W
Biochim Biophys Acta. 2004
PubMed ID: 15157737
Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells.
Hecker TP, Ding Q, Rege TA, Hanks SK, Gladson CL
Oncogene. 2004
PubMed ID: 15077193
Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility.
Subauste MC, Pertz O, Adamson ED, Turner CE, Junger S, Hahn KM
J Cell Biol. 2004
PubMed ID: 15138291
Differential regulation of focal adhesion kinase and paxillin phosphorylation by the small GTP-binding protein Rho in human corneal epithelial cells.
Saito J, Morishige N, Chikama T, Gu J, Sekiguchi K, Nishida T
Jpn J Ophthalmol. 2004
PubMed ID: 15175910
Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein.
Kurenova E, Xu LH, Yang X, Baldwin AS, Craven RJ, Hanks SK, Liu ZG, Cance WG
Mol Cell Biol. 2004
PubMed ID: 15121855
Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma.
Itoh S, Maeda T, Shimada M, Aishima S, Shirabe K, Tanaka S, Maehara Y
Clin Cancer Res. 2004
PubMed ID: 15102689
Lidocaine increases phosphorylation of focal adhesion kinase in rat hippocampal slices.
Dahmani S, Reynaud C, Tesnière A, Rouelle D, Desmonts JM, Mantz J
Eur J Pharmacol. 2004
PubMed ID: 15063155
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
Genome Res. 2004
PubMed ID: 15060019
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Restoration of resting sarcomere length after uniaxial static strain is regulated by protein kinase Cepsilon and focal adhesion kinase.
Mansour H, de Tombe PP, Samarel AM, Russell B
Circ Res. 2004
PubMed ID: 14963000
Interaction of bcl-2 with Paxillin through its BH4 domain is important during ureteric bud branching.
Sorenson CM
J Biol Chem. 2004
PubMed ID: 14699151
The effect of elevated extracellular glucose on adherens junction proteins in cultured rat heart endothelial cells.
Lee HZ, Yeh FT, Wu CH
Life Sci. 2004
PubMed ID: 14969714
TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.
Xu J, Lai YJ, Lin WC, Lin FT
J Biol Chem. 2004
PubMed ID: 14688263
Focal adhesion kinase regulation of N-WASP subcellular localization and function.
Wu X, Suetsugu S, Cooper LA, Takenawa T, Guan JL
J Biol Chem. 2004
PubMed ID: 14676198
Focal adhesion kinase interacts with the transcriptional coactivator FHL2 and both are overexpressed in epithelial ovarian cancer.
Gabriel B, Mildenberger S, Weisser CW, Metzger E, Gitsch G, Schüle R, Müller JM
Anticancer Res. 2004
PubMed ID: 15161045
Attenuation of mouse mesangial cell contractility by high glucose and mannitol: involvement of protein kinase C and focal adhesion kinase.
Chen JS, Lee HS, Jin JS, Chen A, Lin SH, Ka SM, Lin YF
J Biomed Sci. 2004
PubMed ID: 14966364
Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling.
Palazzo AF, Eng CH, Schlaepfer DD, Marcantonio EE, Gundersen GG
Science. 2004
PubMed ID: 14764879
Multiple connections link FAK to cell motility and invasion.
Schlaepfer DD, Mitra SK
Curr Opin Genet Dev. 2004
PubMed ID: 15108811
Nuclear import of N-terminal FAK by activation of the FcepsilonRI receptor in RBL-2H3 cells.
Jones G, Stewart G
Biochem Biophys Res Commun. 2004
PubMed ID: 14715243
Activation of platelet-activating factor receptor-coupled G alpha q leads to stimulation of Src and focal adhesion kinase via two separate pathways in human umbilical vein endothelial cells.
Deo DD, Bazan NG, Hunt JD
J Biol Chem. 2004
PubMed ID: 14617636
FAK promotes organization of fibronectin matrix and fibrillar adhesions.
Ilić D, Kovacic B, Johkura K, Schlaepfer DD, Tomasević N, Han Q, Kim JB, Howerton K, Baumbusch C, Ogiwara N, Streblow DN, Nelson JA, Dazin P, Shino Y, Sasaki K, Damsky CH
J Cell Sci. 2004
PubMed ID: 14657279
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling.
Thamilselvan V, Basson MD
Gastroenterology. 2004
PubMed ID: 14699482
Transforming growth factor-beta1 stimulated protein kinase B serine-473 and focal adhesion kinase tyrosine phosphorylation dependent on cell adhesion in human hepatocellular carcinoma SMMC-7721 cells.
Xu Z, Ma DZ, Wang LY, Su JM, Zha XL
Biochem Biophys Res Commun. 2003
PubMed ID: 14637150
Alterations in granule matrix and cell surface of focal adhesion kinase-deficient mast cells.
Vial D, Oliver C, Jamur MC, Pastor MV, da Silva Trindade E, Berenstein E, Zhang J, Siraganian RP
J Immunol. 2003
PubMed ID: 14634134
FAK regulates biological processes important for the pathogenesis of cancer.
Gabarra-Niecko V, Schaller MD, Dunty JM
Cancer Metastasis Rev. 2003
PubMed ID: 12884911
v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts.
Moissoglu K, Gelman IH
J Biol Chem. 2003
PubMed ID: 14500722
PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation.
Kadaré G, Toutant M, Formstecher E, Corvol JC, Carnaud M, Boutterin MC, Girault JA
J Biol Chem. 2003
PubMed ID: 14500712
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen.
Naik MU, Naik UP
Blood. 2003
PubMed ID: 12881299
Beta1 integrin/focal adhesion kinase-mediated signaling induces intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation.
Nakayamada S, Okada Y, Saito K, Tamura M, Tanaka Y
J Biol Chem. 2003
PubMed ID: 12954625
PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas.
Okamoto H, Yasui K, Zhao C, Arii S, Inazawa J
Hepatology. 2003
PubMed ID: 14578863
Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and phosphatidylinositol 3-kinase pathways.
Acosta JJ, Muñoz RM, González L, Subtil-Rodríguez A, Dominguez-Caceres MA, García-Martínez JM, Calcabrini A, Lazaro-Trueba I, Martín-Pérez J
Mol Endocrinol. 2003
PubMed ID: 12907754
FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies.
Beggs HE, Schahin-Reed D, Zang K, Goebbels S, Nave KA, Gorski J, Jones KR, Sretavan D, Reichardt LF
Neuron. 2003
PubMed ID: 14642275
Newly established Askin tumor cell line and overexpression of focal adhesion kinase in Ewing sarcoma family of tumors cell lines.
Moritake H, Sugimoto T, Kuroda H, Hidaka F, Takahashi Y, Tsuneyoshi M, Yoshida MA, Cui Q, Akiyoshi K, Izumi T, Nunoi H
Cancer Genet Cytogenet. 2003
PubMed ID: 14553943
Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/phosphatidylinositol 3-kinase and MAPK signaling pathway.
Liu XW, Bernardo MM, Fridman R, Kim HR
J Biol Chem. 2003
PubMed ID: 12904305
Focal adhesion kinase pp125FAK interacts with the large conductance calcium-activated hSlo potassium channel in human osteoblasts: potential role in mechanotransduction.
Rezzonico R, Cayatte C, Bourget-Ponzio I, Romey G, Belhacene N, Loubat A, Rocchi S, Van Obberghen E, Girault JA, Rossi B, Schmid-Antomarchi H
J Bone Miner Res. 2003
PubMed ID: 14584897
Regulation of the expression and activity of beta1,4-galactosyltransferase I by focal adhesion kinase.
Ji SY, Zhu XY, Chen S, Shen AG, Yin XL, Chen C, Yao LY, Gu JX
Mol Cell Biochem. 2003
PubMed ID: 14577571
Genistein, a protein tyrosine kinase inhibitor, suppresses the fusogenicity of Moloney murine leukemia virus envelope protein in XC cells.
Kubo Y, Ishimoto A, Amanuma H
Arch Virol. 2003
PubMed ID: 14551814
Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain.
Hoellerer MK, Noble ME, Labesse G, Campbell ID, Werner JM, Arold ST
Structure. 2003
PubMed ID: 14527389
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.
Aszodi A, Hunziker EB, Brakebusch C, Fässler R
Genes Dev. 2003
PubMed ID: 14522949
Involvement of the beta3 E749ATSTFTN756 region in stabilizing integrin alphaIIbbeta3-ligand interaction.
Litjens PE, Gorter G, Ylänne J, Akkerman JW, van Willigen G
J Thromb Haemost. 2003
PubMed ID: 14521607
Activation of focal adhesion kinase by protein kinase C epsilon in neonatal rat ventricular myocytes.
Heidkamp MC, Bayer AL, Scully BT, Eble DM, Samarel AM
Am J Physiol Heart Circ Physiol. 2003
PubMed ID: 12829427
Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase.
Avraham HK, Lee TH, Koh Y, Kim TA, Jiang S, Sussman M, Samarel AM, Avraham S
J Biol Chem. 2003
PubMed ID: 12844492
Lymphocyte function-associated antigen-1-mediated T cell adhesion is impaired by low molecular weight phosphotyrosine phosphatase-dependent inhibition of FAK activity.
Giannoni E, Chiarugi P, Cozzi G, Magnelli L, Taddei ML, Fiaschi T, Buricchi F, Raugei G, Ramponi G
J Biol Chem. 2003
PubMed ID: 12815062
Two types of calcium channels regulating activation of proline-rich tyrosine kinase 2 induced by transient brain ischemia in rat hippocampus.
Liu Y, Zhang GY, Hou XY, Xu TL
Neurosci Lett. 2003
PubMed ID: 12932810
The expression and tyrosine phosphorylation of E-cadherin/catenin adhesion complex, and focal adhesion kinase in invasive cervical carcinomas.
Moon HS, Park WI, Choi EA, Chung HW, Kim SC
Int J Gynecol Cancer. 2003
PubMed ID: 14675348
Degradation and dephosphorylation of focal adhesion kinase during okadaic acid-induced apoptosis in human neuroblastoma cells.
Kim B, van Golen CM, Feldman EL
Neoplasia. 2003
PubMed ID: 14670178
Protein kinase C epsilon-dependent activation of proline-rich tyrosine kinase 2 in neonatal rat ventricular myocytes.
Bayer AL, Heidkamp MC, Howes AL, Heller Brown J, Byron KL, Samarel AM
J Mol Cell Cardiol. 2003
PubMed ID: 12967635
Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration.
Xie Z, Sanada K, Samuels BA, Shih H, Tsai LH
Cell. 2003
PubMed ID: 12941275
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors.
Finnemann SC
EMBO J. 2003
PubMed ID: 12912913
An endogenous inhibitor of focal adhesion kinase blocks Rac1/JNK but not Ras/ERK-dependent signaling in vascular smooth muscle cells.
Sundberg LJ, Galante LM, Bill HM, Mack CP, Taylor JM
J Biol Chem. 2003
PubMed ID: 12782622
Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines.
Golubovskaya VM, Gross S, Kaur AS, Wilson RI, Xu LH, Yang XH, Cance WG
Mol Cancer Res. 2003
PubMed ID: 12939401
Focal adhesion kinase is required for endothelin-induced cell cycle progression of cultured astrocytes.
Koyama Y, Yoshioka Y, Matsuda T, Baba A
Glia. 2003
PubMed ID: 12838510
Targeting membrane-localized focal adhesion kinase to focal adhesions: roles of tyrosine phosphorylation and SRC family kinases.
Katz BZ, Romer L, Miyamoto S, Volberg T, Matsumoto K, Cukierman E, Geiger B, Yamada KM
J Biol Chem. 2003
PubMed ID: 12754219
Tumor necrosis factor-induced nuclear factor kappaB activation is impaired in focal adhesion kinase-deficient fibroblasts.
Funakoshi-Tago M, Sonoda Y, Tanaka S, Hashimoto K, Tago K, Tominaga S, Kasahara T
J Biol Chem. 2003
PubMed ID: 12748169
Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes.
Torsoni AS, Constancio SS, Nadruz W, Hanks SK, Franchini KG
Circ Res. 2003
PubMed ID: 12805241
Direct interaction of focal adhesion kinase with p190RhoGEF.
Zhai J, Lin H, Nie Z, Wu J, Cañete-Soler R, Schlaepfer WW, Schlaepfer DD
J Biol Chem. 2003
PubMed ID: 12702722
Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis.
Beviglia L, Golubovskaya V, Xu L, Yang X, Craven RJ, Cance WG
Biochem J. 2003
PubMed ID: 12659633
Bombesin, lysophosphatidic acid, and epidermal growth factor rapidly stimulate focal adhesion kinase phosphorylation at Ser-910: requirement for ERK activation.
Hunger-Glaser I, Salazar EP, Sinnett-Smith J, Rozengurt E
J Biol Chem. 2003
PubMed ID: 12692126
Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2.
Rose DM, Liu S, Woodside DG, Han J, Schlaepfer DD, Ginsberg MH
J Immunol. 2003
PubMed ID: 12794117
Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression.
Zhao J, Bian ZC, Yee K, Chen BP, Chien S, Guan JL
Mol Cell. 2003
PubMed ID: 12820964
Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium.
Yi XP, Wang X, Gerdes AM, Li F
Hypertension. 2003
PubMed ID: 12732587
Activation of pp125FAK by type 2B recombinant von Willebrand factor binding to platelet GPIb at a high shear rate occurs independently of alpha IIb beta 3 engagement.
Mekrache M, Bachelot-Loza C, Ajzenberg N, Saci A, Legendre P, Baruch D
Blood. 2003
PubMed ID: 12543870
Phosphospecific site tyrosine phosphorylation of p125FAK and proline-rich kinase 2 is differentially regulated by cholecystokinin receptor type A activation in pancreatic acini.
Pace A, García-Marin LJ, Tapia JA, Bragado MJ, Jensen RT
J Biol Chem. 2003
PubMed ID: 12651850
hsp72 inhibits focal adhesion kinase degradation in ATP-depleted renal epithelial cells.
Mao H, Li F, Ruchalski K, Mosser DD, Schwartz JH, Wang Y, Borkan SC
J Biol Chem. 2003
PubMed ID: 12611892
Focal adhesion kinase is required, but not sufficient, for the induction of long-term potentiation in dentate gyrus neurons in vivo.
Yang YC, Ma YL, Chen SK, Wang CW, Lee EH
J Neurosci. 2003
PubMed ID: 12764094
Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility.
Hanks SK, Ryzhova L, Shin NY, Brábek J
Front Biosci. 2003
PubMed ID: 12700132
Endothelial barrier strengthening by activation of focal adhesion kinase.
Quadri SK, Bhattacharjee M, Parthasarathi K, Tanita T, Bhattacharya J
J Biol Chem. 2003
PubMed ID: 12556538
Signaling between focal adhesion kinase and trio.
Medley QG, Buchbinder EG, Tachibana K, Ngo H, Serra-Pagès C, Streuli M
J Biol Chem. 2003
PubMed ID: 12551902
Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase.
Thannickal VJ, Lee DY, White ES, Cui Z, Larios JM, Chacon R, Horowitz JC, Day RM, Thomas PE
J Biol Chem. 2003
PubMed ID: 12531888
Inhibition of focal adhesion kinase by antisense oligonucleotides enhances the sensitivity of breast cancer cells to camptothecins.
Satoh TH, Surmacz TA, Nyormoi O, Whitacre CM
Biocell. 2003
PubMed ID: 12847914
Physiologic role of decidual beta1 integrin and focal adhesion kinase in embryonic implantation.
Hanashi H, Shiokawa S, Akimoto Y, Sakai K, Sakai K, Suzuki N, Kabir-Salmani M, Nagamatsu S, Iwashita M, Nakamura Y
Endocr J. 2003
PubMed ID: 12803239
Differential regulation of cell motility and invasion by FAK.
Hsia DA, Mitra SK, Hauck CR, Streblow DN, Nelson JA, Ilic D, Huang S, Li E, Nemerow GR, Leng J, Spencer KS, Cheresh DA, Schlaepfer DD
J Cell Biol. 2003
PubMed ID: 12615911
Differential role of proline-rich tyrosine kinase 2 and focal adhesion kinase in determining glioblastoma migration and proliferation.
Lipinski CA, Tran NL, Bay C, Kloss J, McDonough WS, Beaudry C, Berens ME, Loftus JC
Mol Cancer Res. 2003
PubMed ID: 12651906
Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting.
Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E
J Neurosci. 2003
PubMed ID: 12629171
Dissociation of focal adhesion kinase and paxillin tyrosine phosphorylation induced by bombesin and lysophosphatidic acid from epidermal growth factor receptor transactivation in Swiss 3T3 cells.
Salazar EP, Hunger-Glaser I, Rozengurt E
J Cell Physiol. 2003
PubMed ID: 12548551
Focal adhesion kinase is required for blood vessel morphogenesis.
Ilic D, Kovacic B, McDonagh S, Jin F, Baumbusch C, Gardner DG, Damsky CH
Circ Res. 2003
PubMed ID: 12595342
The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo.
Kim S, Ko J, Shin H, Lee JR, Lim C, Han JH, Altrock WD, Garner CC, Gundelfinger ED, Premont RT, Kaang BK, Kim E
J Biol Chem. 2003
PubMed ID: 12473661
MEK kinase 1 interacts with focal adhesion kinase and regulates insulin receptor substrate-1 expression.
Yujiri T, Nawata R, Takahashi T, Sato Y, Tanizawa Y, Kitamura T, Oka Y
J Biol Chem. 2003
PubMed ID: 12458213
High glucose levels inhibit focal adhesion kinase-mediated wound healing of rat peritoneal mesothelial cells.
Tamura M, Osajima A, Nakayamada S, Anai H, Kabashima N, Kanegae K, Ota T, Tanaka Y, Nakashima Y
Kidney Int. 2003
PubMed ID: 12631140
R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins.
Kwong L, Wozniak MA, Collins AS, Wilson SD, Keely PJ
Mol Cell Biol. 2003
PubMed ID: 12529399
The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells.
Holmqvist K, Cross M, Riley D, Welsh M
Cell Signal. 2003
PubMed ID: 12464388
Site-specific phosphorylation of platelet focal adhesion kinase by low-density lipoprotein.
Relou IA, Bax LA, van Rijn HJ, Akkerman JW
Biochem J. 2003
PubMed ID: 12387730
Reelin activates SRC family tyrosine kinases in neurons.
Bock HH, Herz J
Curr Biol. 2003
PubMed ID: 12526740
Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin.
Messina S, Onofri F, Bongiorno-Borbone L, Giovedì S, Valtorta F, Girault JA, Benfenati F
J Neurochem. 2003
PubMed ID: 12558988
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Gonadotropin releasing hormone analogue therapy alters signal transduction pathways involving mitogen-activated protein and focal adhesion kinases in leiomyoma.
Chegini N, Kornberg L
J Soc Gynecol Investig. 2003
PubMed ID: 12517589
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography.
Nowakowski J, Cronin CN, McRee DE, Knuth MW, Nelson CG, Pavletich NP, Rogers J, Sang BC, Scheibe DN, Swanson RV, Thompson DA
Structure. 2002
PubMed ID: 12467573
Inhibition of migration of human glioblastoma cells by cerivastatin in association with focal adhesion kinase (FAK).
Obara S, Nakata M, Takeshima H, Kuratsu J, Maruyama I, Kitajima I
Cancer Lett. 2002
PubMed ID: 12169389
The focal adhesion kinase amino-terminal domain localises to nuclei and intercellular junctions in HEK 293 and MDCK cells independently of tyrosine 397 and the carboxy-terminal domain.
Stewart A, Ham C, Zachary I
Biochem Biophys Res Commun. 2002
PubMed ID: 12435390
Alternative splicing controls the mechanisms of FAK autophosphorylation.
Toutant M, Costa A, Studler JM, Kadaré G, Carnaud M, Girault JA
Mol Cell Biol. 2002
PubMed ID: 12391143
Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation.
Katz BZ, Miyamoto S, Teramoto H, Zohar M, Krylov D, Vinson C, Gutkind JS, Yamada KM
Biochim Biophys Acta. 2002
PubMed ID: 12379477
Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells.
Golubovskaya V, Beviglia L, Xu LH, Earp HS, Craven R, Cance W
J Biol Chem. 2002
PubMed ID: 12167618
Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397.
Leu TH, Maa MC
Oncogene. 2002
PubMed ID: 12370821
The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism.
Li X, Meriane M, Triki I, Shekarabi M, Kennedy TE, Larose L, Lamarche-Vane N
J Biol Chem. 2002
PubMed ID: 12149262
Tenascin-C modulates matrix contraction via focal adhesion kinase- and Rho-mediated signaling pathways.
Midwood KS, Schwarzbauer JE
Mol Biol Cell. 2002
PubMed ID: 12388760
Expression of focal adhesion kinase in normal and pathologic human prostate tissues.
Rovin JD, Frierson HF, Ledinh W, Parsons JT, Adams RB
Prostate. 2002
PubMed ID: 12242727
CD44 signaling through focal adhesion kinase and its anti-apoptotic effect.
Fujita Y, Kitagawa M, Nakamura S, Azuma K, Ishii G, Higashi M, Kishi H, Hiwasa T, Koda K, Nakajima N, Harigaya K
FEBS Lett. 2002
PubMed ID: 12297287
A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated.
Takino T, Yoshioka K, Miyamori H, Yamada KM, Sato H
Oncogene. 2002
PubMed ID: 12226752
Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth.
Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU
J Biol Chem. 2002
PubMed ID: 12110680
Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells.
Chen BH, Tzen JT, Bresnick AR, Chen HC
J Biol Chem. 2002
PubMed ID: 12105199
Syndecan-4 modulates focal adhesion kinase phosphorylation.
Wilcox-Adelman SA, Denhez F, Goetinck PF
J Biol Chem. 2002
PubMed ID: 12087088
[Expression analysis of protein tyrosine kinases of the FAK (focal adhesion kinase) family in osteosarcoma]
Schröder A, Delling G, Kaiser EA
Pathologe. 2002
PubMed ID: 12376862
Regulation of focal adhesion kinase by a novel protein inhibitor FIP200.
Abbi S, Ueda H, Zheng C, Cooper LA, Zhao J, Christopher R, Guan JL
Mol Biol Cell. 2002
PubMed ID: 12221124
Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance.
Su JM, Gui L, Zhou YP, Zha XL
World J Gastroenterol. 2002
PubMed ID: 12174366
EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas).
Carter N, Nakamoto T, Hirai H, Hunter T
Nat Cell Biol. 2002
PubMed ID: 12134157
Fibre-type specific concentration of focal adhesion kinase at the sarcolemma: influence of fibre innervation and regeneration.
Flück M, Ziemiecki A, Billeter R, Müntener M
J Exp Biol. 2002
PubMed ID: 12124360
Functional involvement of src and focal adhesion kinase in a CD99 splice variant-induced motility of human breast cancer cells.
Lee HJ, Kim E, Jee B, Hahn JH, Han K, Jung KC, Park SH, Lee H
Exp Mol Med. 2002
PubMed ID: 12216109
Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt.
Kim B, Feldman EL
J Biol Chem. 2002
PubMed ID: 12011046
A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling.
Kirsch K, Kensinger M, Hanafusa H, August A
BMC Cell Biol. 2002
PubMed ID: 12119061
Mitogen-induced, FAK-dependent tyrosine phosphorylation of the SSeCKS scaffolding protein.
Xia W, Gelman IH
Exp Cell Res. 2002
PubMed ID: 12083796
beta 1 integrin regulates fibroblast viability during collagen matrix contraction through a phosphatidylinositol 3-kinase/Akt/protein kinase B signaling pathway.
Tian B, Lessan K, Kahm J, Kleidon J, Henke C
J Biol Chem. 2002
PubMed ID: 11986332
Activation of Wiskott-Aldrich syndrome protein and its association with other proteins by stromal cell-derived factor-1alpha is associated with cell migration in a T-lymphocyte line.
Okabe S, Fukuda S, Broxmeyer HE
Exp Hematol. 2002
PubMed ID: 12135674
Nck-2 interacts with focal adhesion kinase and modulates cell motility.
Goicoechea SM, Tu Y, Hua Y, Chen K, Shen TL, Guan JL, Wu C
Int J Biochem Cell Biol. 2002
PubMed ID: 11950595
A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration.
Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, Turner CE, Schwartz MA, Ginsberg MH
J Biol Chem. 2002
PubMed ID: 11919182
Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation.
Kasahara T, Koguchi E, Funakoshi M, Aizu-Yokota E, Sonoda Y
Antioxid Redox Signal. 2002
PubMed ID: 12215217
FAK-mediated inhibition of vascular smooth muscle cell migration by the tetraspanin CD9.
Scherberich A, Giannone G, Perennou E, Takeda K, Boucheix C, Rubinstein E, Lanza F, Beretz A
Thromb Haemost. 2002
PubMed ID: 12083484
The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly.
Liu Y, Loijens JC, Martin KH, Karginov AV, Parsons JT
Mol Biol Cell. 2002
PubMed ID: 12058076
Possible involvement of the vascular endothelial growth factor-Flt-1-focal adhesion kinase pathway in chemotaxis and the cell proliferation of osteoclast precursor cells in arthritic joints.
Matsumoto Y, Tanaka K, Hirata G, Hanada M, Matsuda S, Shuto T, Iwamoto Y
J Immunol. 2002
PubMed ID: 12023386
Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways.
Gu J, Fujibayashi A, Yamada KM, Sekiguchi K
J Biol Chem. 2002
PubMed ID: 11891225
Focal adhesion kinase (FAK) regulates insulin-stimulated glycogen synthesis in hepatocytes.
Huang D, Cheung AT, Parsons JT, Bryer-Ash M
J Biol Chem. 2002
PubMed ID: 11809746
Primary arrest of circulating platelets on collagen involves phosphorylation of Syk, cortactin and focal adhesion kinase: studies under flow conditions.
Arderiu G, Díaz-Ricart M, Buckley B, Escolar G, Ordinas A
Biochem J. 2002
PubMed ID: 11988077
[Focal adhesion kinase and mitogen activated protein kinase are involved in vascular smooth muscle cells migration and proliferation stimulated by fibronectin]
Yin H, Wang L, Huo Y, Peng X, Xia C, Tang C
Zhonghua Yi Xue Za Zhi. 2002
PubMed ID: 12133485
Flp recombinase transgenic mice of C57BL/6 strain for conditional gene targeting.
Takeuchi T, Nomura T, Tsujita M, Suzuki M, Fuse T, Mori H, Mishina M
Biochem Biophys Res Commun. 2002
PubMed ID: 12051751
Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples.
Hecker TP, Grammer JR, Gillespie GY, Stewart J, Gladson CL
Cancer Res. 2002
PubMed ID: 11980671
Mutated focal adhesion kinase induces apoptosis in a human glioma cell line, T98G.
Sakurai S, Sonoda Y, Koguchi E, Shinoura N, Hamada H, Kasahara T
Biochem Biophys Res Commun. 2002
PubMed ID: 12054581
Trichostatin A-induced detransformation correlates with decreased focal adhesion kinase phosphorylation at tyrosine 861 in ras-transformed fibroblasts.
Lim Y, Han I, Kwon HJ, Oh ES
J Biol Chem. 2002
PubMed ID: 11821402
Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase.
Chikumi H, Fukuhara S, Gutkind JS
J Biol Chem. 2002
PubMed ID: 11799111
Activated focal adhesion kinase involved in adhesion and migration of vascular smooth muscle cells stimulated by fibronectin.
Yin H, Wang L, Huo Y, Peng X, Xia C, Tang C
Chin Med J (Engl). 2002
PubMed ID: 12133282
Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling.
Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA
J Cell Biol. 2002
PubMed ID: 11927607
The structural basis of localization and signaling by the focal adhesion targeting domain.
Arold ST, Hoellerer MK, Noble ME
Structure. 2002
PubMed ID: 12005431
Proline-rich tyrosine kinase 2 and focal adhesion kinase are involved in different phases of platelet activation by vWF.
Canobbio I, Lova P, Sinigaglia F, Balduini C, Torti M
Thromb Haemost. 2002
PubMed ID: 11916084
PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow.
Haier J, Nicolson GL
Oncogene. 2002
PubMed ID: 11857088
The focal adhesion kinase--a regulator of cell migration and invasion.
Hauck CR, Hsia DA, Schlaepfer DD
IUBMB Life. 2002
PubMed ID: 12049193
Differential regulation of components of the focal adhesion complex by heregulin: role of phosphatase SHP-2.
Vadlamudi RK, Adam L, Nguyen D, Santos M, Kumar R
J Cell Physiol. 2002
PubMed ID: 11807823
The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin.
Hayashi I, Vuori K, Liddington RC
Nat Struct Biol. 2002
PubMed ID: 11799401
The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling.
Hagel M, George EL, Kim A, Tamimi R, Opitz SL, Turner CE, Imamoto A, Thomas SM
Mol Cell Biol. 2002
PubMed ID: 11784865
Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells.
Freitas F, Jeschke M, Majstorovic I, Mueller DR, Schindler P, Voshol H, Van Oostrum J, Susa M
Bone. 2002
PubMed ID: 11792571
FAK regulates tyrosine phosphorylation of CAS, paxillin, and PYK2 in cells expressing v-Src, but is not a critical determinant of v-Src transformation.
Roy S, Ruest PJ, Hanks SK
J Cell Biochem. 2002
PubMed ID: 11787067
Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration.
Panetti TS
Front Biosci. 2002
PubMed ID: 11779709
Role of tyrosine phosphorylation in ligand-independent sequestration of CXCR4 in human primary monocytes-macrophages.
Wang J, Guan E, Roderiquez G, Calvert V, Alvarez R, Norcross MA
J Biol Chem. 2001
PubMed ID: 11668182
Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin.
Chellaiah MA, Biswas RS, Yuen D, Alvarez UM, Hruska KA
J Biol Chem. 2001
PubMed ID: 11577104
Basal keratinocytes from uninvolved psoriatic skin exhibit accelerated spreading and focal adhesion kinase responsiveness to fibronectin.
Chen G, McCormick TS, Hammerberg C, Ryder-Diggs S, Stevens SR, Cooper KD
J Invest Dermatol. 2001
PubMed ID: 11886520
Decreased focal adhesion kinase suppresses papilloma formation during experimental mouse skin carcinogenesis.
McLean GW, Brown K, Arbuckle MI, Wyke AW, Pikkarainen T, Ruoslahti E, Frame MC
Cancer Res. 2001
PubMed ID: 11731413
Signalling of GPI-anchored CD157 via focal adhesion kinase in MCA102 fibroblasts.
Liang F, Qi RZ, Chang CF
FEBS Lett. 2001
PubMed ID: 11602246
Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion.
Poullet P, Gautreau A, Kadaré G, Girault JA, Louvard D, Arpin M
J Biol Chem. 2001
PubMed ID: 11468295
Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase.
Fresu M, Bianchi M, Parsons JT, Villa-Moruzzi E
Biochem J. 2001
PubMed ID: 11513739
The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase.
Izaguirre G, Aguirre L, Hu YP, Lee HY, Schlaepfer DD, Aneskievich BJ, Haimovich B
J Biol Chem. 2001
PubMed ID: 11369769
Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy.
Kovacic-Milivojević B, Roediger F, Almeida EA, Damsky CH, Gardner DG, Ilić D
Mol Biol Cell. 2001
PubMed ID: 11514617
Overexpression of the focal adhesion kinase (p125FAK) in the vascular smooth muscle cells of intimal hyperplasia.
Owens LV, Xu L, Marston WA, Yang X, Farber MA, Iacocca MV, Cance WG, Keagy BA
J Vasc Surg. 2001
PubMed ID: 11496289
Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase.
Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K
Mol Cell Biol. 2001
PubMed ID: 11463817
Biochemical signals and biological responses elicited by the focal adhesion kinase.
Schaller MD
Biochim Biophys Acta. 2001
PubMed ID: 11476890
Phosphorylation of focal adhesion kinase (pp125(FAK)) is increased in human keratinocytes induced to migrate by extracellular matrices.
Yurko MA, O'Toole EA, Woodley DT
J Cell Physiol. 2001
PubMed ID: 11382919
Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-PEST-mediated dephosphorylation.
Lyons PD, Dunty JM, Schaefer EM, Schaller MD
J Biol Chem. 2001
PubMed ID: 11337490
B cell receptor signaling involves physical and functional association of FAK with Lyn and IgM.
Mlinaric-Rascan I, Yamamoto T
FEBS Lett. 2001
PubMed ID: 11389892
Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase.
Lu Z, Jiang G, Blume-Jensen P, Hunter T
Mol Cell Biol. 2001
PubMed ID: 11359909
Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion.
Xie B, Zhao J, Kitagawa M, Durbin J, Madri JA, Guan JL, Fu XY
J Biol Chem. 2001
PubMed ID: 11278462
The v-Src SH3 domain facilitates a cell adhesion-independent association with focal adhesion kinase.
Hauck CR, Hunter T, Schlaepfer DD
J Biol Chem. 2001
PubMed ID: 11278488
The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases.
Arold ST, Ulmer TS, Mulhern TD, Werner JM, Ladbury JE, Campbell ID, Noble ME
J Biol Chem. 2001
PubMed ID: 11278857
Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies.
Nakamura K, Yano H, Schaefer E, Sabe H
Oncogene. 2001
PubMed ID: 11420674
Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas.
Noguchi T, Tsuda M, Takeda H, Takada T, Inagaki K, Yamao T, Fukunaga K, Matozaki T, Kasuga M
J Biol Chem. 2001
PubMed ID: 11278335
Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain.
Chen R, Kim O, Li M, Xiong X, Guan JL, Kung HJ, Chen H, Shimizu Y, Qiu Y
Nat Cell Biol. 2001
PubMed ID: 11331870
Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrin.
Even-Ram SC, Maoz M, Pokroy E, Reich R, Katz BZ, Gutwein P, Altevogt P, Bar-Shavit R
J Biol Chem. 2001
PubMed ID: 11278329
Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II.
Zvara A, Fajardo JE, Escalante M, Cotton G, Muir T, Kirsch KH, Birge RB
Oncogene. 2001
PubMed ID: 11314030
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Variations of proline-rich kinase Pyk2 expression correlate with prostate cancer progression.
Stanzione R, Picascia A, Chieffi P, Imbimbo C, Palmieri A, Mirone V, Staibano S, Franco R, De Rosa G, Schlessinger J, Tramontano D
Lab Invest. 2001
PubMed ID: 11204274
Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role in modulating binding to p130(Cas).
Ma A, Richardson A, Schaefer EM, Parsons JT
Mol Biol Cell. 2001
PubMed ID: 11160818
Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation.
Geng L, Burrow CR, Li HP, Wilson PD
Biochim Biophys Acta. 2000
PubMed ID: 11113628
Cell adhesion and focal adhesion kinase regulate insulin receptor substrate-1 expression.
Lebrun P, Baron V, Hauck CR, Schlaepfer DD, Van Obberghen E
J Biol Chem. 2000
PubMed ID: 10967115
The protein tyrosine kinase family of the human genome.
Robinson DR, Wu YM, Lin SF
Oncogene. 2000
PubMed ID: 11114734
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor.
Gotoh T, Cai D, Tian X, Feig LA, Lerner A
J Biol Chem. 2000
PubMed ID: 10896938
Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly.
Zhao ZS, Manser E, Loo TH, Lim L
Mol Cell Biol. 2000
PubMed ID: 10938112
Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin.
Ryu H, Lee JH, Kim KS, Jeong SM, Kim PH, Chung HT
J Immunol. 2000
PubMed ID: 10925297
Echistatin inhibits pp125FAK autophosphorylation, paxillin phosphorylation and pp125FAK-paxillin interaction in fibronectin-adherent melanoma cells.
Della Morte R, Squillacioti C, Garbi C, Derkinderen P, Belisario MA, Girault JA, Di Natale P, Nitsch L, Staiano N
Eur J Biochem. 2000
PubMed ID: 10931187
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes.
Cance WG, Harris JE, Iacocca MV, Roche E, Yang X, Chang J, Simkins S, Xu L
Clin Cancer Res. 2000
PubMed ID: 10873094
Beta 1-integrin-mediated cell signaling in T lymphocytes.
Iwata S, Ohashi Y, Kamiguchi K, Morimoto C
J Dermatol Sci. 2000
PubMed ID: 10808124
Tyrosine dephosphorylation, but not phosphorylation, of p130Cas is dependent on integrin alpha IIb beta 3-mediated aggregation in platelets: implication of p130Cas involvement in pathways unrelated to cytoskeletal reorganization.
Ohmori T, Yatomi Y, Inoue K, Satoh K, Ozaki Y
Biochemistry. 2000
PubMed ID: 10801330
Protein complexes involving alpha v beta 3 integrins, nonmuscle myosin heavy chain-A, and focal adhesion kinase from in thrombospondin-treated smooth muscle cells.
Sajid M, Hu Z, Lele M, Stouffer GA
J Investig Med. 2000
PubMed ID: 10822899
FAK integrates growth-factor and integrin signals to promote cell migration.
Sieg DJ, Hauck CR, Ilic D, Klingbeil CK, Schaefer E, Damsky CH, Schlaepfer DD
Nat Cell Biol. 2000
PubMed ID: 10806474
Suppression of Pyk2 kinase and cellular activities by FIP200.
Ueda H, Abbi S, Zheng C, Guan JL
J Cell Biol. 2000
PubMed ID: 10769033
Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C.
Wang JF, Park IW, Groopman JE
Blood. 2000
PubMed ID: 10753828
Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1.
Littlewood Evans A, Müller U
Nat Genet. 2000
PubMed ID: 10742111
Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA.
Prakash SK, Paylor R, Jenna S, Lamarche-Vane N, Armstrong DL, Xu B, Mancini MA, Zoghbi HY
Hum Mol Genet. 2000
PubMed ID: 10699171
Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation.
Miao H, Burnett E, Kinch M, Simon E, Wang B
Nat Cell Biol. 2000
PubMed ID: 10655584
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
Eisenmann KM, McCarthy JB, Simpson MA, Keely PJ, Guan JL, Tachibana K, Lim L, Manser E, Furcht LT, Iida J
Nat Cell Biol. 1999
PubMed ID: 10587647
Degraded collagen fragments promote rapid disassembly of smooth muscle focal adhesions that correlates with cleavage of pp125(FAK), paxillin, and talin.
Carragher NO, Levkau B, Ross R, Raines EW
J Cell Biol. 1999
PubMed ID: 10545505
Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma.
Judson PL, He X, Cance WG, Van Le L
Cancer. 1999
PubMed ID: 10526262
Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases.
Schaller MD, Hildebrand JD, Parsons JT
Mol Biol Cell. 1999
PubMed ID: 10512882
Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase.
Zhang Z, Hernandez-Lagunas L, Horne WC, Baron R
J Biol Chem. 1999
PubMed ID: 10455189
Association of focal adhesion kinase with Grb7 and its role in cell migration.
Han DC, Guan JL
J Biol Chem. 1999
PubMed ID: 10446223
Focal adhesion kinase promotes phospholipase C-gamma1 activity.
Zhang X, Chattopadhyay A, Ji QS, Owen JD, Ruest PJ, Carpenter G, Hanks SK
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10430888
Focal adhesion kinase, paxillin, and bcl-2: analysis of expression, phosphorylation, and association during morphogenesis.
Sorenson CM, Sheibani N
Dev Dyn. 1999
PubMed ID: 10417825
Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration.
Sieg DJ, Hauck CR, Schlaepfer DD
J Cell Sci. 1999
PubMed ID: 10413676
Characterization of the murine mafF gene.
Onodera K, Shavit JA, Motohashi H, Katsuoka F, Akasaka JE, Engel JD, Yamamoto M
J Biol Chem. 1999
PubMed ID: 10409670
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway.
Tamura M, Gu J, Danen EH, Takino T, Miyamoto S, Yamada KM
J Biol Chem. 1999
PubMed ID: 10400703
Role of focal adhesion kinase in MAP kinase activation by insulin-like growth factor-I or insulin.
Arbet-Engels C, Janknecht R, Eckhart W
FEBS Lett. 1999
PubMed ID: 10431817
Induction of phosphorylation and intracellular association of CC chemokine receptor 5 and focal adhesion kinase in primary human CD4+ T cells by macrophage-tropic HIV envelope.
Cicala C, Arthos J, Ruiz M, Vaccarezza M, Rubbert A, Riva A, Wildt K, Cohen O, Fauci AS
J Immunol. 1999
PubMed ID: 10384144
Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.
Owen JD, Ruest PJ, Fry DW, Hanks SK
Mol Cell Biol. 1999
PubMed ID: 10373530
Mapping the mouse otoconin-90 (Oc90) gene to chromosome 15.
Wang Y, Thalmann I, Thalmann R, Ornitz DM
Genomics. 1999
PubMed ID: 10366455
T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.
Venables JP, Vernet C, Chew SL, Elliott DJ, Cowmeadow RB, Wu J, Cooke HJ, Artzt K, Eperon IC
Hum Mol Genet. 1999
PubMed ID: 10332027
Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling.
Turner CE, Brown MC, Perrotta JA, Riedy MC, Nikolopoulos SN, McDonald AR, Bagrodia S, Thomas S, Leventhal PS
J Cell Biol. 1999
PubMed ID: 10330411
Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility.
Mañes S, Mira E, Gómez-Mouton C, Zhao ZJ, Lacalle RA, Martínez-A C
Mol Cell Biol. 1999
PubMed ID: 10082579
The 5'-flanking region of the mouse adenylyl cyclase type VIII gene imparts tissue-specific expression in transgenic mice.
Muglia LM, Schaefer ML, Vogt SK, Gurtner G, Imamura A, Muglia LJ
J Neurosci. 1999
PubMed ID: 10066258
Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts.
Angers-Loustau A, Côté JF, Charest A, Dowbenko D, Spencer S, Lasky LA, Tremblay ML
J Cell Biol. 1999
PubMed ID: 10085298
De novo expression of pp125FAK in human macrophages regulates CSK distribution and MAP kinase activation but does not affect focal contact structure.
De Nichilo MO, Katz BZ, O'Connell B, Yamada KM
J Cell Physiol. 1999
PubMed ID: 10048580
Low density lipoprotein phosphorylates the focal adhesion-associated kinase p125(FAK) in human platelets independent of integrin alphaIIb beta3.
Hackeng CM, Pladet MW, Akkerman JW, van Rijn HJ
J Biol Chem. 1999
PubMed ID: 9867854
Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin.
Thomas SM, Hagel M, Turner CE
J Cell Sci. 1999
PubMed ID: 9858471
Signaling through focal adhesion kinase.
Schlaepfer DD, Hauck CR, Sieg DJ
Prog Biophys Mol Biol. 1999
PubMed ID: 10354709
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).
Zhu T, Goh EL, LeRoith D, Lobie PE
J Biol Chem. 1998
PubMed ID: 9837978
Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125(FAK) and pp60(src).
Lebrun P, Mothe-Satney I, Delahaye L, Van Obberghen E, Baron V
J Biol Chem. 1998
PubMed ID: 9822703
Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles.
Borowsky ML, Hynes RO
J Cell Biol. 1998
PubMed ID: 9786953
Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration.
Sieg DJ, Ilić D, Jones KC, Damsky CH, Hunter T, Schlaepfer DD
EMBO J. 1998
PubMed ID: 9774338
Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase.
Fujita H, Kamiguchi K, Cho D, Shibanuma M, Morimoto C, Tachibana K
J Biol Chem. 1998
PubMed ID: 9756887
Dot far-western blot analysis of relative binding affinities of the Src homology 3 domains of Efs and its related proteins.
Ohba T, Ishino M, Aoto H, Sasaki T
Anal Biochem. 1998
PubMed ID: 9750131
HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.
Milani D, Mazzoni M, Zauli G, Mischiati C, Gibellini D, Giacca M, Capitani S
AIDS. 1998
PubMed ID: 9708406
Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide.
Gervais FG, Thornberry NA, Ruffolo SC, Nicholson DW, Roy S
J Biol Chem. 1998
PubMed ID: 9642276
Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin.
Brown MC, Perrotta JA, Turner CE
Mol Biol Cell. 1998
PubMed ID: 9658172
Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix.
Slack BE
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9636140
Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events.
Schlaepfer DD, Jones KC, Hunter T
Mol Cell Biol. 1998
PubMed ID: 9566877
Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription.
Zhu T, Goh EL, Lobie PE
J Biol Chem. 1998
PubMed ID: 9553131
p125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors.
Baron V, Calléja V, Ferrari P, Alengrin F, Van Obberghen E
J Biol Chem. 1998
PubMed ID: 9507031
Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin.
Shen Y, Schneider G, Cloutier JF, Veillette A, Schaller MD
J Biol Chem. 1998
PubMed ID: 9497381
A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions.
Ribon V, Herrera R, Kay BK, Saltiel AR
J Biol Chem. 1998
PubMed ID: 9461600
Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion.
Zheng C, Xing Z, Bian ZC, Guo C, Akbay A, Warner L, Guan JL
J Biol Chem. 1998
PubMed ID: 9442086
Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions.
Matsuya M, Sasaki H, Aoto H, Mitaka T, Nagura K, Ohba T, Ishino M, Takahashi S, Suzuki R, Sasaki T
J Biol Chem. 1998
PubMed ID: 9422762
Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand.
Liu F, Sells MA, Chernoff J
Mol Cell Biol. 1998
PubMed ID: 9418872
Differentiation and transforming growth factor-beta receptor down-regulation by collagen-alpha2beta1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells.
Takeuchi Y, Suzawa M, Kikuchi T, Nishida E, Fujita T, Matsumoto T
J Biol Chem. 1997
PubMed ID: 9361011
Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.
Tachibana K, Urano T, Fujita H, Ohashi Y, Kamiguchi K, Iwata S, Hirai H, Morimoto C
J Biol Chem. 1997
PubMed ID: 9360983
Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants.
Yu R, Tan TH, Kong AN
J Biol Chem. 1997
PubMed ID: 9360968
Alternatively spliced focal adhesion kinase in rat brain with increased autophosphorylation activity.
Burgaya F, Toutant M, Studler JM, Costa A, Le Bert M, Gelman M, Girault JA
J Biol Chem. 1997
PubMed ID: 9353341
Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.
Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J, Beier DR
Genome Res. 1997
PubMed ID: 9371744
Cleavage of focal adhesion kinase by caspases during apoptosis.
Wen LP, Fahrni JA, Troie S, Guan JL, Orth K, Rosen GD
J Biol Chem. 1997
PubMed ID: 9325343
Identification, partial characterization, and genetic mapping of kinesin-like protein genes in mouse.
Yang Z, Hanlon DW, Marszalek JR, Goldstein LS
Genomics. 1997
PubMed ID: 9339368
Relocation of Syk protein-tyrosine kinase to the actin filament network and subsequent association with Fak.
Sada K, Minami Y, Yamamura H
Eur J Biochem. 1997
PubMed ID: 9342235
T cell receptor engagement induces tyrosine phosphorylation of FAK and Pyk2 and their association with Lck.
Berg NN, Ostergaard HL
J Immunol. 1997
PubMed ID: 9257837
Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin.
Bellis SL, Perrotta JA, Curtis MS, Turner CE
Biochem J. 1997
PubMed ID: 9230116
Localization of somatostatin receptor genes on mouse chromosomes 2, 11, 12, 15, and 17: correlation with growth QTLs.
Brinkmeier ML, Camper SA
Genomics. 1997
PubMed ID: 9226367
Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3.
Chung J, Gao AG, Frazier WA
J Biol Chem. 1997
PubMed ID: 9169439
Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src.
Schlaepfer DD, Hunter T
J Biol Chem. 1997
PubMed ID: 9148935
NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn).
Beggs HE, Baragona SC, Hemperly JJ, Maness PF
J Biol Chem. 1997
PubMed ID: 9079653
Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins.
Mazaki Y, Hashimoto S, Sabe H
J Biol Chem. 1997
PubMed ID: 9054445
Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins.
Schlaepfer DD, Broome MA, Hunter T
Mol Cell Biol. 1997
PubMed ID: 9032297
Focal adhesion kinase: at the crossroads of signal transduction.
Ilić D, Damsky CH, Yamamoto T
J Cell Sci. 1997
PubMed ID: 9067592
Focal adhesion and stress fiber formation is regulated by tyrosine phosphatase activity.
Retta SF, Barry ST, Critchley DR, Defilippi P, Silengo L, Tarone G
Exp Cell Res. 1996
PubMed ID: 8986614
Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src.
Calalb MB, Zhang X, Polte TR, Hanks SK
Biochem Biophys Res Commun. 1996
PubMed ID: 8941336
Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding.
Brown MC, Perrotta JA, Turner CE
J Cell Biol. 1996
PubMed ID: 8922390
Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase.
Chen HC, Appeddu PA, Isoda H, Guan JL
J Biol Chem. 1996
PubMed ID: 8824286
p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene.
Salgia R, Pisick E, Sattler M, Li JL, Uemura N, Wong WK, Burky SA, Hirai H, Chen LB, Griffin JD
J Biol Chem. 1996
PubMed ID: 8810278
Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes.
Minegishi M, Tachibana K, Sato T, Iwata S, Nojima Y, Morimoto C
J Exp Med. 1996
PubMed ID: 8879209
Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases.
Schlaepfer DD, Hunter T
Mol Cell Biol. 1996
PubMed ID: 8816475
Regulation of a neuronal form of focal adhesion kinase by anandamide.
Derkinderen P, Toutant M, Burgaya F, Le Bert M, Siciliano JC, de Franciscis V, Gelman M, Girault JA
Science. 1996
PubMed ID: 8781236
Regulation and activation of focal adhesion kinase and paxillin during the adhesion, proliferation, and differentiation of prostatic epithelial cells in vitro and in vivo.
Tremblay L, Hauck W, Nguyen LT, Allard P, Landry F, Chapdelaine A, Chevalier S
Mol Endocrinol. 1996
PubMed ID: 8843417
Focal adhesion kinase-related fakB is regulated by the integrin LFA-1 and interacts with the SH3 domain of phospholipase C gamma 1.
Kanner SB
Cell Immunol. 1996
PubMed ID: 8660853
Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae.
Law SF, Estojak J, Wang B, Mysliwiec T, Kruh G, Golemis EA
Mol Cell Biol. 1996
PubMed ID: 8668148
An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase.
Hildebrand JD, Taylor JM, Parsons JT
Mol Cell Biol. 1996
PubMed ID: 8649427
Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases.
Vuori K, Hirai H, Aizawa S, Ruoslahti E
Mol Cell Biol. 1996
PubMed ID: 8649368
Cloning of focal adhesion kinase, pp125FAK, from rat brain reveals multiple transcripts with different patterns of expression.
Burgaya F, Girault JA
Brain Res Mol Brain Res. 1996
PubMed ID: 8738136
Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton.
Yoshida M, Westlin WF, Wang N, Ingber DE, Rosenzweig A, Resnick N, Gimbrone MA
J Cell Biol. 1996
PubMed ID: 8609175
The association of focal adhesion kinase with a 200-kDa protein that is tyrosine phosphorylated in response to platelet-derived growth factor.
Chen HC, Guan JL
Eur J Biochem. 1996
PubMed ID: 8654393
p59fyn-p125FAK cooperation in development of CD4+CD8+ thymocytes.
Kanazawa S, Ilić D, Hashiyama M, Noumura T, Yamamoto T, Suda T, Aizawa S
Blood. 1996
PubMed ID: 8562954
Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer.
Owens LV, Xu L, Dent GA, Yang X, Sturge GC, Craven RJ, Cance WG
Ann Surg Oncol. 1996
PubMed ID: 8770310
Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK.
Furuta Y, Ilić D, Kanazawa S, Takeda N, Yamamoto T, Aizawa S
Oncogene. 1995
PubMed ID: 7478517
Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas.
Polte TR, Hanks SK
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7479864
p125FAK tyrosine phosphorylation and focal adhesion assembly: studies with phosphotyrosine phosphatase inhibitors.
Defilippi P, Retta SF, Olivo C, Palmieri M, Venturino M, Silengo L, Tarone G
Exp Cell Res. 1995
PubMed ID: 7589239
Integrin stimulation decreases tyrosine phosphorylation and activity of focal adhesion kinase in thymocytes.
Kanazawa S, Ilic D, Noumura T, Yamamoto T, Aizawa S
Biochem Biophys Res Commun. 1995
PubMed ID: 7487975
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice.
Ilić D, Furuta Y, Kanazawa S, Takeda N, Sobue K, Nakatsuji N, Nomura S, Fujimoto J, Okada M, Yamamoto T
Nature. 1995
PubMed ID: 7566154
Interaction of focal adhesion kinase with cytoskeletal protein talin.
Chen HC, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan JL
J Biol Chem. 1995
PubMed ID: 7622520
Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin.
Kharbanda S, Saleem A, Yuan Z, Emoto Y, Prasad KV, Kufe D
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7597091
A 77-kDa protein associates with pp125FAK in mast cells and becomes tyrosine-phosphorylated by high affinity IgE receptor aggregation.
Hamawy MM, Minoguchi K, Swaim WD, Mergenhagen SE, Siraganian RP
J Biol Chem. 1995
PubMed ID: 7744883
Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase.
Guinebault C, Payrastre B, Racaud-Sultan C, Mazarguil H, Breton M, Mauco G, Plantavid M, Chap H
J Cell Biol. 1995
PubMed ID: 7537275
Focal adhesion kinase is not essential for in vitro and in vivo differentiation of ES cells.
Ilic D, Furuta Y, Suda T, Atsumi T, Fujimoto J, Ikawa Y, Yamamoto T, Aizawa S
Biochem Biophys Res Commun. 1995
PubMed ID: 7726850
Mapping of the focal adhesion kinase (Fadk) gene to mouse chromosome 15 and human chromosome 8.
Fiedorek FT, Kay ES
Mamm Genome. 1995
PubMed ID: 7766995
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases.
Calalb MB, Polte TR, Hanks SK
Mol Cell Biol. 1995
PubMed ID: 7529876
Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading.
Bergman M, Joukov V, Virtanen I, Alitalo K
Mol Cell Biol. 1995
PubMed ID: 7529872
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase.
Schlaepfer DD, Hanks SK, Hunter T, van der Geer P
Nature. 1994
PubMed ID: 7997267
SH2 domain specificity and activity modified by a single residue.
Marengere LE, Songyang Z, Gish GD, Schaller MD, Parsons JT, Stern MJ, Cantley LC, Pawson T
Nature. 1994
PubMed ID: 7515480
Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain.
Xing Z, Chen HC, Nowlen JK, Taylor SJ, Shalloway D, Guan JL
Mol Biol Cell. 1994
PubMed ID: 8054685
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.
Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR, Parsons JT
Mol Cell Biol. 1994
PubMed ID: 7509446
A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.
Lee ST, Strunk KM, Spritz RA
Oncogene. 1993
PubMed ID: 8247543
Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK.
Whitney GS, Chan PY, Blake J, Cosand WL, Neubauer MG, Aruffo A, Kanner SB
DNA Cell Biol. 1993
PubMed ID: 7692878
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D
Science. 1993
PubMed ID: 8493579
Expression of an N-terminally truncated form of human focal adhesion kinase in brain.
André E, Becker-André M
Biochem Biophys Res Commun. 1993
PubMed ID: 8422239
Focal adhesion kinase (p125FAK): a point of convergence in the action of neuropeptides, integrins, and oncogenes.
Zachary I, Rozengurt E
Cell. 1992
PubMed ID: 1458538
Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.
Hanks SK, Calalb MB, Harper MC, Patel SK
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1528852

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	5747	14083	25614
EnsEMBL Gene(s)	ENSG00000169398	ENSMUSG00000022607	ENSRNOG00000007916
Unigene	Hs.395482	Mm.254494	Rn.2809
Homologene	PTK2	Ptk2	Ptk2
OMIM	600758	N/A	N/A
GeneCards	PTK2	N/A	N/A
Beta Cell Genomics	DT.100767523 DT.100826834 DT.100826836 DT.100826838 DT.40252503 DT.405051 DT.86857405 DT.92452096 DT.95330431 DT.97762498	DT.101398350 DT.101398354 DT.110838878 DT.110839021 DT.110839026 DT.491966 DT.55274363 DT.91359236 DT.94277536 DT.97382310	N/A
Reactome	Q05397	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	5747	14083	25614

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
PTK2	SAE1	IntAct	empirical	21988832
PTK2	DDX39A	BioGRID	empirical	21900206
PTK2	EFS	HPRD, BioGRID	empirical	9750131
PTK2	CIB1	HPRD, BioGRID	empirical	12881299
PTK2	SORBS1	HPRD	empirical	9461600
PTK2	CCR5	HPRD, BioGRID	empirical	10384144
PTK2	CRK	HPRD, BioGRID	empirical	11314030 7509446 7529876 12370821 12615911 10085298
PTK2	PARP1	BioGRID	empirical	18206965
PTK2	CSK	HPRD, BioGRID	empirical	7529872
PTK2	CSPG4	HPRD	empirical	10587647
PTK2	DAG1	BioGRID	empirical	18341635
PTK2	DCC	HPRD, IntAct, BioGRID	empirical	15494733 20434207
PTK2	DMD	BioGRID	empirical	16935300
PTK2	DNM2	HPRD	empirical	15895076
PTK2	DOCK1	BioGRID	empirical	12615911
PTK2	EEF1G	BioGRID	empirical	21900206
PTK2	EGFR	HPRD, IntAct, BioGRID	empirical	10806474 15657067
PTK2	EPHA2	HPRD, IntAct, BioGRID	empirical	10655584
PTK2	ELAVL1	MINT	empirical	18273060
PTK2	EPHB2	HPRD, IntAct	empirical	16298995 18713744
PTK2	ERBB2	HPRD, IntAct	empirical	11807823 21034468
PTK2	ERBB3	HPRD	empirical	11807823
PTK2	F13A1	BioGRID	empirical	21900206
PTK2	PTK2B	HPRD	empirical	16760434
PTK2	FBP1	BioGRID	empirical	21900206
PTK2	FGR	HPRD, BioGRID	empirical	12387730
PTK2	ARHGAP26	HPRD, BioGRID	empirical	8649427
PTK2	NACAD	BioGRID	empirical	21900206
PTK2	MAPK8IP3	HPRD, BioGRID	empirical	12226752
PTK2	FLT1	HPRD	empirical	12023386
PTK2	FLT4	HPRD	empirical	16452200
PTK2	FYN	HPRD, MINT, IntAct	empirical	11278857 15102471
PTK2	GAPDH	BioGRID	empirical	18206965
PTK2	AMPH	BioGRID	empirical	12558988
PTK2	BIN1	HPRD, BioGRID	empirical	12558988
PTK2	GRB2	HPRD, IntAct, BioGRID, Reactome	empirical	7997267 16298995 10806474 10085298 8649427 12558988 12005431 21900206
PTK2	GRB7	HPRD, MINT, BioGRID	empirical	10446223 17318180
PTK2	GIT1	HPRD, BioGRID	empirical	10938112 12629171 12473661
PTK2	GSK3B	HPRD, BioGRID	empirical	11809746
PTK2	GSN	BioGRID	empirical	11577104
PTK2	GZMB	HPRD	empirical	9642276
PTK2	HES1	BioGRID	empirical	21900206
PTK2	IGF1R	BioGRID	empirical	10082579
PTK2	IGHM	HPRD	empirical	11389892
PTK2	INSR	HPRD	empirical	7529876 9507031
PTK2	IRS1	HPRD, BioGRID	empirical	9822703
PTK2	ITGA4	BioGRID	empirical	11919182
PTK2	ITGAV	HPRD	empirical	11927607
PTK2	ITGB1	BioGRID	empirical	16935300
PTK2	ITGB2	HPRD	empirical	8649427
PTK2	ITGB3	HPRD, BioGRID	empirical	8649427 11927607 9169439
PTK2	ITGB4	HPRD	empirical	12110680
PTK2	ITGB5	BioGRID	empirical	11927607
PTK2	JAK2	HPRD, BioGRID	empirical	9553131 10925297
PTK2	KCNMA1	HPRD	empirical	14584897
PTK2	L1CAM	MINT	empirical	18464795
PTK2	LCK	HPRD	empirical	9257837
PTK2	LYN	HPRD, MINT, BioGRID	empirical	11389892 9169439
PTK2	MDM2	BioGRID	empirical	18206965
PTK2	NASP	BioGRID	empirical	21900206
PTK2	NCK1	BioGRID	empirical	8879209 11950595
PTK2	NEDD8	HPRD, BioGRID	empirical	16620772
PTK2	NEDD9	HPRD, BioGRID	empirical	8668148 8879209 10455189
PTK2	NEO1	HPRD, BioGRID	empirical	15494733
PTK2	ASAP1	HPRD	empirical	12058076
PTK2	ANGPTL4	IntAct	empirical	21397862
PTK2	PCSK1	BioGRID	empirical	11113628
PTK2	PDGFRB	HPRD	empirical	10806474
PTK2	PIK3R1	HPRD, BioGRID	empirical	7537275 8649427 10806474
PTK2	PKD1	HPRD	empirical	11113628
PTK2	PLCG1	HPRD, BioGRID	empirical	8660853 10430888
PTK2	PPP1CB	HPRD, MINT, BioGRID	empirical	11513739
PTK2	ZNF331	BioGRID	empirical	21900206
PTK2	PTK2	HPRD, BioGRID	empirical	7529876 11314030 7509446 12370821 8816475 7997267 17192257 12005431
PTK2	PTPN1	MINT	empirical	9418872 16291744
PTK2	PTPN11	HPRD, BioGRID	empirical	10655584 7589239 8986614 10082579
PTK2	PTPN12	HPRD	empirical	9497381 11314030 10400703
PTK2	PTPRH	HPRD	empirical	11278335
PTK2	PTPRJ	MINT	empirical	15735685
PTK2	PXN	HPRD, MINT, IntAct, MIPS, BioGRID	empirical	9658172 11337490 9230116 10931187 9756887 21034468 21741599 16298995 10545505 11784715 10417825 11514617 9422762 10330411 11919182 9054445 9442086 8922390 10455189 10753828
PTK2	RHOU	IntAct	empirical	18086875
PTK2	DLGAP3	HPRD	empirical	16202977
PTK2	RAC1	IntAct, BioGRID	empirical	20936779
PTK2	BCL2	BioGRID	empirical	10417825
PTK2	RET	HPRD	empirical	16153436
PTK2	ROCK1	HPRD	empirical	15247219
PTK2	SELE	HPRD, BioGRID	empirical	8609175
PTK2	SHC1	HPRD, BioGRID	empirical	11980671
PTK2	TNS3	IntAct	empirical	19732724
PTK2	MICAL1	HPRD	empirical	10808124
PTK2	EPS8L2	BioGRID	empirical	21900206
PTK2	BMX	HPRD, BioGRID	empirical	11331870
PTK2	SOS1	Reactome	predicted
PTK2	SRC	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	7529876 8054685 10931187 9507031 8816475 7997267 11927607 8941336 16291744 17525734 18464795 16966330 21034468 12615911 11980671 10085298 12387730 12558988 9822703
PTK2	STAT1	HPRD, BioGRID	empirical	11278462
PTK2	STAT3	BioGRID	empirical	10925297
PTK2	SYK	HPRD, BioGRID	empirical	9342235 9169439
PTK2	TGFB1I1	HPRD, IntAct, BioGRID	empirical	9756887 9422762 11463817 9858471 21900206
PTK2	TIA1	MINT	empirical	18273060
PTK2	TLN1	HPRD, BioGRID	empirical	7622520 9442086
PTK2	TNFRSF1A	HPRD	empirical	12748169
PTK2	TNS1	HPRD	empirical	9553131
PTK2	TP53	HPRD, IntAct, BioGRID	empirical	15855171 18206965
PTK2	TRIO	HPRD	empirical	12551902
PTK2	TRIP6	HPRD, BioGRID	empirical	14688263
PTK2	TSC1	BioGRID	empirical	17043358
PTK2	TSC2	HPRD, BioGRID	empirical	17043358
PTK2	UBC	BioGRID	empirical	18031698 22203672 21139048
PTK2	VCL	HPRD, MIPS	empirical	10545505
PTK2	EZR	HPRD, BioGRID	empirical	11468295
PTK2	YES1	BioGRID	empirical	12558988
PTK2	CXCR4	HPRD	empirical	11668182
PTK2	BBS10	BioGRID	empirical	21900206
PTK2	NCK2	HPRD, BioGRID	empirical	11950595
PTK2	PIAS1	HPRD	empirical	14500712
PTK2	CBL	BioGRID	empirical	22203672
PTK2	ACTN1	HPRD	empirical	11369769
PTK2	RIPK1	HPRD	empirical	15121855
PTK2	NRP1	MINT	empirical	18464795
PTK2	SOCS2	HPRD, MINT, BioGRID	empirical	16189514
PTK2	CCNA1	IntAct	empirical	17353931
PTK2	SOCS3	BioGRID	empirical	18031698
PTK2	ATG12	HPRD, MINT, BioGRID	empirical	16189514
PTK2	LPXN	HPRD, BioGRID	empirical	18497331 21900206
PTK2	BCAR1	HPRD, MINT, IntAct, MIPS, BioGRID	empirical	11514617 7479864 9360983 12119061 9360968 9285683 21034468 10545505 8810278 12615911 8649427 11577104 12135674 10753828
PTK2	CD47	HPRD	empirical	9169439
PTK2	CD79B	HPRD	empirical	11389892
PTK2	RB1CC1	HPRD, BioGRID	empirical	10769033