Home PTEN
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(Human) GRCh37 - chr10:89622870..89731687 (108.82 kb) View in Genome Browser
(Mouse) NCBIM37 - chr19:32831987..32900650 (68.66 kb) View in Genome Browser
(Rat) RGSC3.4 - chr1:236771027..236837261 (66.23 kb) View in Genome Browser
HaemAtlas Expression Table for PTEN:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for PTEN:The PTEN interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| PTEN | CENPC1 | IntAct | empirical | 17218262 |
| PTEN | UTP14A | HPRD, MINT, IntAct | empirical | 16169070 |
| PTEN | COPS6 | HPRD, MINT, IntAct | empirical | 16169070 |
| PTEN | CHGB | HPRD, MINT, IntAct | empirical | 16169070 |
| PTEN | CSNK2A1 | HPRD | empirical | 12297295 |
| PTEN | CSNK2A2 | HPRD | empirical | 12297295 |
| PTEN | DLG1 | HPRD, IntAct, MIPS | empirical | 10646847 15951562 |
| PTEN | AKT1 | HPRD | empirical | 12077256 10866658 12297295 |
| PTEN | MAST1 | HPRD, IntAct | empirical | 15951562 |
| PTEN | MAST3 | HPRD, IntAct | empirical | 15951562 |
| PTEN | MAST2 | HPRD, IntAct, MIPS | empirical | 15951562 10646847 |
| PTEN | FRK | IntAct | empirical | 19345329 |
| PTEN | MAGI3 | HPRD, MINT, IntAct | empirical | 10748157 15951562 |
| PTEN | ANG | HPRD, IntAct | empirical | 16169070 |
| PTEN | ANAPC4 | IntAct | empirical | 21241890 |
| PTEN | HBA1 | HPRD | empirical | 16169070 |
| PTEN | HSPA5 | IntAct | empirical | 18064632 |
| PTEN | AR | HPRD | empirical | 15205473 |
| PTEN | NEDD4 | IntAct | empirical | 19345329 |
| PTEN | ANAPC5 | IntAct | empirical | 21241890 |
| PTEN | ANAPC7 | IntAct | empirical | 21241890 |
| PTEN | PDGFRB | MINT | empirical | 16456542 |
| PTEN | PPP1CA | HPRD, IntAct | empirical | 17274640 |
| PTEN | PTEN | IntAct | empirical | 17218262 |
| PTEN | PXN | HPRD | empirical | 11857088 |
| PTEN | SMURF2 | IntAct | empirical | 19379695 |
| PTEN | STK11 | HPRD | empirical | 15987703 |
| PTEN | TP53 | HPRD | empirical | 12620407 |
| PTEN | UBE2I | HPRD | empirical | 12620973 |
| PTEN | UBE2L3 | HPRD | empirical | 12620973 |
| PTEN | CAV1 | HPRD, MINT | empirical | 12176037 |
| PTEN | SLC9A3R2 | HPRD, MINT | empirical | 16456542 |
| PTEN | SLC9A3R1 | HPRD, MINT | empirical | 16456542 |
| PTEN | MAGI2 | HPRD, IntAct | empirical | 10760291 15951562 |
| PTEN | CDC27 | IntAct | empirical | 21241890 |
| PTEN | MVP | HPRD | empirical | 12177006 |
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Type 1 Diabetes Publications: 15
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Rictor/mTORC2 Is Essential for Maintaining a Balance Between {beta}-Cell Proliferation and Cell Size.
Gu Y, Lindner J, Kumar A, Yuan W, Magnuson MA
Diabetes. 2011
PubMed ID: 21266327
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Deletion of Pten in pancreatic ß-cells protects against deficient ß-cell mass and function in mouse models of type 2 diabetes.
Wang L, Liu Y, Yan Lu S, Nguyen KT, Schroer SA, Suzuki A, Mak TW, Gaisano H, Woo M
Diabetes. 2010
PubMed ID: 20852026
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Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic beta-cells.
Hou R, Zhang J, Yin T, Cao H, Zhang N, Li X, Wang L, Xing Y, Li D, Ji Q
Apoptosis. 2010
PubMed ID: 20464496
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Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice.
Xu X, Ehdaie B, Ohara N, Yoshino T, Deng CX
Oncogene. 2009
PubMed ID: 19901970
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Insulin granule recruitment and exocytosis is dependent on p110{gamma} in insulinoma and human {beta}-cells.
Pigeau GM, Kolic J, Ball BJ, Hoppa MB, Wang YW, Rückle T, Woo M, Manning Fox JE, Macdonald PE
Diabetes. 2009
PubMed ID: 19549714
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Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice.
Chen WS, Peng XD, Wang Y, Xu PZ, Chen ML, Luo Y, Jeon SM, Coleman K, Haschek WM, Bass J, Philipson LH, Hay N
Mol Cell Biol. 2009
PubMed ID: 19289493
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Leptin dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels.
Ning K, Miller LC, Laidlaw HA, Watterson KR, Gallagher J, Sutherland C, Ashford ML
J Biol Chem. 2009
PubMed ID: 19208634
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PTEN deletion and concomitant c-Myc activation do not lead to tumor formation in pancreatic beta cells.
Radziszewska A, Choi D, Nguyen KT, Schroer SA, Tajmir P, Wang L, Suzuki A, Mak TW, Evan GI, Woo M
J Biol Chem. 2009
PubMed ID: 19056726
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Partial deletion of Pten in the hypothalamus leads to growth defects that cannot be rescued by exogenous growth hormone.
Choi D, Nguyen KT, Wang L, Schroer SA, Suzuki A, Mak TW, Woo M
Endocrinology. 2008
PubMed ID: 18499759
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Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity.
Wong JT, Kim PT, Peacock JW, Yau TY, Mui AL, Chung SW, Sossi V, Doudet D, Green D, Ruth TJ, Parsons R, Verchere CB, Ong CJ
Diabetologia. 2007
PubMed ID: 17195063
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A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells.
Ning K, Miller LC, Laidlaw HA, Burgess LA, Perera NM, Downes CP, Leslie NR, Ashford ML
EMBO J. 2006
PubMed ID: 16675953
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Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo.
Nguyen KT, Tajmir P, Lin CH, Liadis N, Zhu XD, Eweida M, Tolasa-Karaman G, Cai F, Wang R, Kitamura T, Belsham DD, Wheeler MB, Suzuki A, Mak TW, Woo M
Mol Cell Biol. 2006
PubMed ID: 16738317
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Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes.
Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H
Mol Cell Biol. 2006
PubMed ID: 16537919
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Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis.
Kushner JA, Simpson L, Wartschow LM, Guo S, Rankin MM, Parsons R, White MF
J Biol Chem. 2005
PubMed ID: 16170201
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Muscle-specific Pten deletion protects against insulin resistance and diabetes.
Wijesekara N, Konrad D, Eweida M, Jefferies C, Liadis N, Giacca A, Crackower M, Suzuki A, Mak TW, Kahn CR, Klip A, Woo M
Mol Cell Biol. 2005
PubMed ID: 15657439
Publications: 1463
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Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia.
Howitt J, Lackovic J, Low LH, Naguib A, Macintyre A, Goh CP, Callaway JK, Hammond V, Thomas T, Dixon M, Putz U, Silke J, Bartlett P, Yang B, Kumar S, Trotman LC, Tan SS
J Cell Biol. 2012
PubMed ID: 22213801
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PTEN-mediated AKT activation contributes to the reduced apoptosis among Indian oral squamous cell carcinoma patients.
Alyasiri NS, Mehdi SJ, Alam MS, Ali A, Mandal AK, Gupta S, Singh I, Rizvi MM
J Cancer Res Clin Oncol. 2012
PubMed ID: 22033727
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Transient silencing of PTEN in human CD34(+) cells enhances their proliferative potential and ability to engraft immunodeficient mice.
Kim I, Kim YJ, Métais JY, Dunbar CE, Larochelle A
Exp Hematol. 2012
PubMed ID: 22019626
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PTEN interacts with metal-responsive transcription factor 1 and stimulates its transcriptional activity.
Lin MC, Liu YC, Tam MF, Lu YJ, Hsieh YT, Lin LY
Biochem J. 2012
PubMed ID: 21883094
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Transcriptomic analysis of mouse embryonic skin cells reveals previously unreported genes expressed in melanoblasts.
Colombo S, Champeval D, Rambow F, Larue L
J Invest Dermatol. 2012
PubMed ID: 21850021
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TSC1/TSC2 inactivation inhibits AKT through mTORC1-dependent up-regulation of STAT3-PTEN cascade.
Zha X, Hu Z, He S, Wang F, Shen H, Zhang H
Cancer Lett. 2011
PubMed ID: 22055460
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Inactivation of Rac1 reduces Trastuzumab resistance in PTEN deficient and insulin-like growth factor I receptor overexpressing human breast cancer SKBR3 cells.
Zhao Y, Wang Z, Jiang Y, Yang C
Cancer Lett. 2011
PubMed ID: 21943825
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Sustained axon regeneration induced by co-deletion of PTEN and SOCS3.
Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z
Nature. 2011
PubMed ID: 22056987
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PI3K/mTOR signaling regulates prostatic branching morphogenesis.
Ghosh S, Lau H, Simons BW, Powell JD, Meyers DJ, De Marzo AM, Berman DM, Lotan TL
Dev Biol. 2011
PubMed ID: 22015718
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PTEN and PIK3CA gene copy numbers and poor outcomes in non-small cell lung cancer patients with gefitinib therapy.
Fidler MJ, Morrison LE, Basu S, Buckingham L, Walters K, Batus M, Jacobson KK, Jewell SS, Coon J, Bonomi PD
Br J Cancer. 2011
PubMed ID: 22095222
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PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase.
Mondal S, Ghosh-Roy S, Loison F, Li Y, Jia Y, Harris C, Williams DA, Luo HR
J Immunol. 2011
PubMed ID: 22043008
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Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) is required for the estradiol-dependent increase of phosphatase and tensin homolog (PTEN) protein expression.
Yang L, Wang Y, Chen P, Hu J, Xiong Y, Feng D, Liu H, Zhang H, Yang H, He J
Endocrinology. 2011
PubMed ID: 21990315
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Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with Cowden and Cowden-like syndrome characterized by germline PTEN, SDH, or KLLN alterations.
Ngeow J, Mester J, Rybicki LA, Ni Y, Milas M, Eng C
J Clin Endocrinol Metab. 2011
PubMed ID: 21956414
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Serum response factor regulates expression of phosphatase and tensin homolog through a microRNA network in vascular smooth muscle cells.
Horita HN, Simpson PA, Ostriker A, Furgeson S, Van Putten V, Weiser-Evans MC, Nemenoff RA
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21940949
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Differential requirements for c-Myc in chronic hematopoietic hyperplasia and acute hematopoietic malignancies in Pten-null mice.
Zhang J, Xiao Y, Guo Y, Breslin P, Zhang S, Wei W, Zhang Z, Zhang J
Leukemia. 2011
PubMed ID: 21926961
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Novel prognostic markers in the serum of patients with castration-resistant prostate cancer derived from quantitative analysis of the pten conditional knockout mouse proteome.
Kälin M, Cima I, Schiess R, Fankhauser N, Powles T, Wild P, Templeton A, Cerny T, Aebersold R, Krek W, Gillessen S
Eur Urol. 2011
PubMed ID: 21741162
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Hydrogen sulfide and L-cysteine increase phosphatidylinositol 3,4,5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (A
Manna P, Jain SK
J Biol Chem. 2011
PubMed ID: 21953448
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The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal.
Wang J, Han F, Wu J, Lee SW, Chan CH, Wu CY, Yang WL, Gao Y, Zhang X, Jeong YS, Moten A, Samaniego F, Huang P, Liu Q, Zeng YX, Lin HK
Blood. 2011
PubMed ID: 21931116
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PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability.
Furumoto Y, Charles N, Olivera A, Leung WH, Dillahunt S, Sargent JL, Tinsley K, Odom S, Scott E, Wilson TM, Ghoreschi K, Kneilling M, Chen M, Lee DM, Bolland S, Rivera J
Blood. 2011
PubMed ID: 21926349
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Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis.
Darido C, Georgy SR, Wilanowski T, Dworkin S, Auden A, Zhao Q, Rank G, Srivastava S, Finlay MJ, Papenfuss AT, Pandolfi PP, Pearson RB, Jane SM
Cancer Cell. 2011
PubMed ID: 22094257
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Differential Akt signalling in non-seminomatous testicular germ cell tumors.
Hennenlotter J, Amend B, Vogel U, Renninger M, Springer C, Kuehs U, Stenzl A, Bedke J
Anticancer Res. 2011
PubMed ID: 22110200
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Pioglitazone induces a proadipogenic antitumor response in mice with PAX8-PPARgamma fusion protein thyroid carcinoma.
Dobson ME, Diallo-Krou E, Grachtchouk V, Yu J, Colby LA, Wilkinson JE, Giordano TJ, Koenig RJ
Endocrinology. 2011
PubMed ID: 21952241
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MicroRNA-1 transfected embryonic stem cells enhance cardiac myocyte differentiation and inhibit apoptosis by modulating the PTEN/Akt pathway in the infarcted heart.
Glass C, Singla DK
Am J Physiol Heart Circ Physiol. 2011
PubMed ID: 21856911
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Intestinal epithelial-specific PTEN inactivation results in tumor formation.
Byun DS, Ahmed N, Nasser S, Shin J, Al-Obaidi S, Goel S, Corner GA, Wilson AJ, Flanagan DJ, Williams DS, Augenlicht LH, Vincan E, Mariadason JM
Am J Physiol Gastrointest Liver Physiol. 2011
PubMed ID: 21836055
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A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes.
Rodríguez-Escudero I, Oliver MD, Andrés-Pons A, Molina M, Cid VJ, Pulido R
Hum Mol Genet. 2011
PubMed ID: 21828076
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Abnormal elevated PTEN expression in the mouse antrum of a model of GIST Kit(K641E/K641E).
Deneubourg L, Ralea S, Gromova P, Parsons R, Vanderwinden JM, Erneux C
Cell Signal. 2011
PubMed ID: 21757001
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PIK3CA mutations and amplification in endometrioid endometrial carcinomas: relation to other genetic defects and clinicopathologic status of the tumors.
Konopka B, Janiec-Jankowska A, Kwiatkowska E, Najmoła U, Bidziński M, Olszewski W, Goluda C
Hum Pathol. 2011
PubMed ID: 21531001
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PTEN limits alveolar macrophage function against Pseudomonas aeruginosa after bone marrow transplantation.
Hubbard LL, Wilke CA, White ES, Moore BB
Am J Respir Cell Mol Biol. 2011
PubMed ID: 21527775
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PTEN regulates colorectal epithelial apoptosis through Cdc42 signalling.
Deevi R, Fatehullah A, Jagan I, Nagaraju M, Bingham V, Campbell FC
Br J Cancer. 2011
PubMed ID: 21952626
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BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia.
Hurtz C, Hatzi K, Cerchietti L, Braig M, Park E, Kim YM, Herzog S, Ramezani-Rad P, Jumaa H, Müller MC, Hofmann WK, Hochhaus A, Ye BH, Agarwal A, Druker BJ, Shah NP, Melnick AM, Müschen M
J Exp Med. 2011
PubMed ID: 21911423
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Phosphorylation/inactivation of PTEN by Akt-independent PI3K signaling in retinal pigment epithelium.
Lee EJ, Kim N, Kang KH, Kim JW
Biochem Biophys Res Commun. 2011
PubMed ID: 21964287
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Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress.
Lehman JA, Waning DL, Batuello CN, Cipriano R, Kadakia MP, Mayo LD
J Biol Chem. 2011
PubMed ID: 21873427
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Differential regulation of PTEN expression by androgen receptor in prostate and breast cancers.
Wang Y, Romigh T, He X, Tan MH, Orloff MS, Silverman RH, Heston WD, Eng C
Oncogene. 2011
PubMed ID: 21532617
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In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma.
Karreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, DeNicola G, Webster KA, Weiss D, Perez-Mancera PA, Krauthammer M, Halaban R, Provero P, Adams DJ, Tuveson DA, Pandolfi PP
Cell. 2011
PubMed ID: 22000016
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Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs.
Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, Lieberman J, Rigoutsos I, Pandolfi PP
Cell. 2011
PubMed ID: 22000013
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Polo-like kinase 1 facilitates loss of Pten tumor suppressor-induced prostate cancer formation.
Liu XS, Song B, Elzey BD, Ratliff TL, Konieczny SF, Cheng L, Ahmad N, Liu X
J Biol Chem. 2011
PubMed ID: 21890624
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Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC.
Nahar R, Ramezani-Rad P, Mossner M, Duy C, Cerchietti L, Geng H, Dovat S, Jumaa H, Ye BH, Melnick A, Müschen M
Blood. 2011
PubMed ID: 21856866
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Immunohistochemical staining of thyroidectomy specimens for PTEN can aid in the identification of patients with Cowden syndrome.
Barletta JA, Bellizzi AM, Hornick JL
Am J Surg Pathol. 2011
PubMed ID: 21921783
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Immunoexpression status and prognostic value of mTOR and hypoxia-induced pathway members in primary and metastatic clear cell renal cell carcinomas.
Schultz L, Chaux A, Albadine R, Hicks J, Kim JJ, De Marzo AM, Allaf ME, Carducci MA, Rodriguez R, Hammers HJ, Argani P, Reuter VE, Netto GJ
Am J Surg Pathol. 2011
PubMed ID: 21881486
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Mutational analysis of PTEN/PIK3CA/AKT pathway in oral squamous cell carcinoma.
Cohen Y, Goldenberg-Cohen N, Shalmon B, Shani T, Oren S, Amariglio N, Dratviman-Storobinsky O, Shnaiderman-Shapiro A, Yahalom R, Kaplan I, Hirshberg A
Oral Oncol. 2011
PubMed ID: 21824802
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Phosphatase and tensin homolog on chromosome 10 is phosphorylated in primary effusion lymphoma and Kaposi's sarcoma.
Roy D, Dittmer DP
Am J Pathol. 2011
PubMed ID: 21819957
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Loss of PTEN expression by dermal fibroblasts causes skin fibrosis.
Parapuram SK, Shi-wen X, Elliott C, Welch ID, Jones H, Baron M, Denton CP, Abraham DJ, Leask A
J Invest Dermatol. 2011
PubMed ID: 21654839
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HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer.
Ahmad I, Patel R, Singh LB, Nixon C, Seywright M, Barnetson RJ, Brunton VG, Muller WJ, Edwards J, Sansom OJ, Leung HY
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21930937
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Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.
Banerjee S, Crouse NR, Emnett RJ, Gianino SM, Gutmann DH
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21896734
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Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion.
Perry JM, He XC, Sugimura R, Grindley JC, Haug JS, Ding S, Li L
Genes Dev. 2011
PubMed ID: 21890648
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Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice.
Yu X, Shen N, Zhang ML, Pan FY, Wang C, Jia WP, Liu C, Gao Q, Gao X, Xue B, Li CJ
EMBO J. 2011
PubMed ID: 21829168
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Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice.
Xie X, Brown MS, Shelton JM, Richardson JA, Goldstein JL, Liang G
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21896731
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Analysis of PTEN, estrogen receptor α and progesterone receptor expression in endometrial hyperplasia using tissue microarray.
Pieczyńska B, Wojtylak S, Zawrocki A, Biernat W
Pol J Pathol. 2011
PubMed ID: 22102068
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Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis.
Goertz MJ, Wu Z, Gallardo TD, Hamra FK, Castrillon DH
J Clin Invest. 2011
PubMed ID: 21865646
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Abnormal distribution of hDlg and PTEN in premalignant lesions and invasive cervical cancer.
Vázquez-Ulloa E, Lizano M, Avilés-Salas A, Alfaro-Moreno E, Contreras-Paredes A
Gynecol Oncol. 2011
PubMed ID: 21664656
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Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models.
Domanskyi A, Geissler C, Vinnikov IA, Alter H, Schober A, Vogt MA, Gass P, Parlato R, Schütz G
FASEB J. 2011
PubMed ID: 21593433
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Dispensable role of PTEN in mouse spermatogenesis.
Huang Y, Mao X, Boyce T, Zhu GZ
Cell Biol Int. 2011
PubMed ID: 21524277
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Invasiveness and anchorage independent growth ability augmented by PTEN inactivation through the PI3K/AKT/NFkB pathway in lung cancer cells.
Akca H, Demiray A, Tokgun O, Yokota J
Lung Cancer. 2011
PubMed ID: 21333374
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Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain.
Ventruti A, Kazdoba TM, Niu S, D'Arcangelo G
Neuroscience. 2011
PubMed ID: 21664258
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Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.
Chen M, Pratt CP, Zeeman ME, Schultz N, Taylor BS, O'Neill A, Castillo-Martin M, Nowak DG, Naguib A, Grace DM, Murn J, Navin N, Atwal GS, Sander C, Gerald WL, Cordon-Cardo C, Newton AC, Carver BS, Trotman LC
Cancer Cell. 2011
PubMed ID: 21840483
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Overexpression of EZH2 and loss of expression of PTEN is associated with invasion, metastasis, and poor progression of gallbladder adenocarcinoma.
Liu DC, Yang ZL
Pathol Res Pract. 2011
PubMed ID: 21719208
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Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism.
Wu X, Xu K, Zhang L, Deng Y, Lee P, Shapiro E, Monaco M, Makarenkova HP, Li J, Lepor H, Grishina I
Dev Biol. 2011
PubMed ID: 21624358
-
Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo.
Mullany LK, Fan HY, Liu Z, White LD, Marshall A, Gunaratne P, Anderson ML, Creighton CJ, Xin L, Deavers M, Wong KK, Richards JS
Oncogene. 2011
PubMed ID: 21423204
-
PTEN positively regulates UVB-induced DNA damage repair.
Ming M, Feng L, Shea CR, Soltani K, Zhao B, Han W, Smart RC, Trempus CS, He YY
Cancer Res. 2011
PubMed ID: 21771908
-
Aberrant promoter methylation and inactivation of PTEN gene in cervical carcinoma from Indian population.
Rizvi MM, Alam MS, Ali A, Mehdi SJ, Batra S, Mandal AK
J Cancer Res Clin Oncol. 2011
PubMed ID: 21698421
-
PTEN, pAKT, and pmTOR expression and subcellular distribution in primary renal cell carcinomas and their metastases.
Hager M, Haufe H, Lusuardi L, Schmeller N, Kolbitsch C
Cancer Invest. 2011
PubMed ID: 21696297
-
Predicting PTEN mutations: an evaluation of Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome clinical features.
Pilarski R, Stephens JA, Noss R, Fisher JL, Prior TW
J Med Genet. 2011
PubMed ID: 21659347
-
In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer.
Kinross KM, Brown DV, Kleinschmidt M, Jackson S, Christensen J, Cullinane C, Hicks RJ, Johnstone RW, McArthur GA
Mol Cancer Ther. 2011
PubMed ID: 21632463
-
Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes.
Daikoku T, Jackson L, Besnard V, Whitsett J, Ellenson LH, Dey SK
Gynecol Oncol. 2011
PubMed ID: 21570712
-
Mutation of thyroid hormone receptor-β in mice predisposes to the development of mammary tumors.
Guigon CJ, Kim DW, Willingham MC, Cheng SY
Oncogene. 2011
PubMed ID: 21399657
-
PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs.
Weigelt B, Warne PH, Downward J
Oncogene. 2011
PubMed ID: 21358673
-
Slow disease progression in a C57BL/6 pten-deficient mouse model of prostate cancer.
Svensson RU, Haverkamp JM, Thedens DR, Cohen MB, Ratliff TL, Henry MD
Am J Pathol. 2011
PubMed ID: 21703427
-
Prostate epithelial Pten/TP53 loss leads to transformation of multipotential progenitors and epithelial to mesenchymal transition.
Martin P, Liu YN, Pierce R, Abou-Kheir W, Casey O, Seng V, Camacho D, Simpson RM, Kelly K
Am J Pathol. 2011
PubMed ID: 21703421
-
Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo.
Migeotte I, Grego-Bessa J, Anderson KV
Development. 2011
PubMed ID: 21693517
-
Germ-line sequence variants of PTEN do not have an important role in hereditary and non-hereditary prostate cancer susceptibility.
Xie CC, Lu L, Sun J, Zheng SL, Isaacs WB, Gronberg H, Xu J
J Hum Genet. 2011
PubMed ID: 21633361
-
ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells.
Chetram MA, Don-Salu-Hewage AS, Hinton CV
Biochem Biophys Res Commun. 2011
PubMed ID: 21627959
-
Loss of Shp2-mediated mitogen-activated protein kinase signaling in Muller glial cells results in retinal degeneration.
Cai Z, Simons DL, Fu XY, Feng GS, Wu SM, Zhang X
Mol Cell Biol. 2011
PubMed ID: 21576358
-
Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells.
Kim JS, Xu X, Li H, Solomon D, Lane WS, Jin T, Waldman T
Mol Cell Biol. 2011
PubMed ID: 21536651
-
K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder.
Ahmad I, Singh LB, Foth M, Morris CA, Taketo MM, Wu XR, Leung HY, Sansom OJ, Iwata T
Dis Model Mech. 2011
PubMed ID: 21504907
-
Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets.
Clément S, Peyrou M, Sanchez-Pareja A, Bourgoin L, Ramadori P, Suter D, Vinciguerra M, Guilloux K, Pascarella S, Rubbia-Brandt L, Negro F, Foti M
Hepatology. 2011
PubMed ID: 21465511
-
Adenovirus mediated homozygous endometrial epithelial Pten deletion results in aggressive endometrial carcinoma.
Joshi A, Ellenson LH
Exp Cell Res. 2011
PubMed ID: 21397598
-
Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model.
Mester JL, Tilot AK, Rybicki LA, Frazier TW, Eng C
Eur J Hum Genet. 2011
PubMed ID: 21343951
-
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics.
Bonaguidi MA, Wheeler MA, Shapiro JS, Stadel RP, Sun GJ, Ming GL, Song H
Cell. 2011
PubMed ID: 21664664
-
On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN).
Numajiri N, Takasawa K, Nishiya T, Tanaka H, Ohno K, Hayakawa W, Asada M, Matsuda H, Azumi K, Kamata H, Nakamura T, Hara H, Minami M, Lipton SA, Uehara T
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21646525
-
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
-
COP1 is a tumour suppressor that causes degradation of ETS transcription factors.
Vitari AC, Leong KG, Newton K, Yee C, O'Rourke K, Liu J, Phu L, Vij R, Ferrando R, Couto SS, Mohan S, Pandita A, Hongo JA, Arnott D, Wertz IE, Gao WQ, French DM, Dixit VM
Nature. 2011
PubMed ID: 21572435
-
Posttranscriptional deregulation of MYC via PTEN constitutes a major alternative pathway of MYC activation in T-cell acute lymphoblastic leukemia.
Bonnet M, Loosveld M, Montpellier B, Navarro JM, Quilichini B, Picard C, Di Cristofaro J, Bagnis C, Fossat C, Hernandez L, Mamessier E, Roulland S, Morgado E, Formisano-Tréziny C, Dik WA, Langerak AW, Prebet T, Vey N, Michel G, Gabert J, Soulier J, Macintyre EA, Asnafi V, Payet-Bornet D, Nadel B
Blood. 2011
PubMed ID: 21527520
-
E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression.
Lau MT, Klausen C, Leung PC
Oncogene. 2011
PubMed ID: 21297666
-
Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells.
Sugimoto N, Miwa S, Ohno-Shosaku T, Tsuchiya H, Hitomi Y, Nakamura H, Tomita K, Yachie A, Koizumi S
Neurosci Lett. 2011
PubMed ID: 21529704
-
Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model.
Endersby R, Zhu X, Hay N, Ellison DW, Baker SJ
Cancer Res. 2011
PubMed ID: 21507933
-
Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth.
Mulholland DJ, Tran LM, Li Y, Cai H, Morim A, Wang S, Plaisier S, Garraway IP, Huang J, Graeber TG, Wu H
Cancer Cell. 2011
PubMed ID: 21620777
-
Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells.
Koide M, Ikeda K, Akakabe Y, Kitamura Y, Ueyama T, Matoba S, Yamada H, Okigaki M, Matsubara H
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21593423
-
Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex.
Chan CB, Liu X, Pradoldej S, Hao C, An J, Yepes M, Luo HR, Ye K
J Neurosci. 2011
PubMed ID: 21632930
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WWP2 is an E3 ubiquitin ligase for PTEN.
Maddika S, Kavela S, Rani N, Palicharla VR, Pokorny JL, Sarkaria JN, Chen J
Nat Cell Biol. 2011
PubMed ID: 21532586
-
Protein kinase CK2/PTEN pathway plays a key role in platelet-activating factor-mediated murine anaphylactic shock.
Kang NI, Yoon HY, Kim HA, Kim KJ, Han MK, Lee YR, Hwang PH, Soh BY, Shin SJ, Im SY, Lee HK
J Immunol. 2011
PubMed ID: 21531890
-
Differences in myocardial PTEN expression and Akt signalling in type 2 diabetic and nondiabetic patients undergoing coronary bypass surgery.
Wang B, Raedschelders K, Shravah J, Hui Y, Safaei HG, Chen DD, Cook RC, Fradet G, Au CL, Ansley DM
Clin Endocrinol (Oxf). 2011
PubMed ID: 21521253
-
PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer.
Gonzalez-Angulo AM, Ferrer-Lozano J, Stemke-Hale K, Sahin A, Liu S, Barrera JA, Burgues O, Lluch AM, Chen H, Hortobagyi GN, Mills GB, Meric-Bernstam F
Mol Cancer Ther. 2011
PubMed ID: 21490305
-
Post-translational modifications of PTEN and their potential therapeutic implications.
Singh G, Chan AM
Curr Cancer Drug Targets. 2011
PubMed ID: 21486223
-
The PTEN/PI3K/Akt pathway regulates stem-like cells in primary esophageal carcinoma cells.
Li H, Gao Q, Guo L, Lu SH
Cancer Biol Ther. 2011
PubMed ID: 21467840
-
Regulation of phosphatase homologue of tensin protein expression by bone morphogenetic proteins in prostate epithelial cells.
Jerde TJ, Wu Z, Theodorescu D, Bushman W
Prostate. 2011
PubMed ID: 21456062
-
Ischemic preconditioning attenuates mitochondrial localization of PTEN induced by ischemia-reperfusion.
Zu L, Zheng X, Wang B, Parajuli N, Steenbergen C, Becker LC, Cai ZP
Am J Physiol Heart Circ Physiol. 2011
PubMed ID: 21421815
-
SDF-1α induction in mature smooth muscle cells by inactivation of PTEN is a critical mediator of exacerbated injury-induced neointima formation.
Nemenoff RA, Horita H, Ostriker AC, Furgeson SB, Simpson PA, VanPutten V, Crossno J, Offermanns S, Weiser-Evans MC
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21415388
-
Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression.
Lu D, Han C, Wu T
Gastroenterology. 2011
PubMed ID: 21354147
-
Role of microRNA-21 and effect on PTEN in Kazakh's esophageal squamous cell carcinoma.
Ma WJ, Lv GD, Tuersun A, Liu Q, Liu H, Zheng ST, Huang CG, Feng JG, Wang X, Lin RY, Sheyhidin I, Lu XM
Mol Biol Rep. 2011
PubMed ID: 21104017
-
Association of sporadic breast cancer with PTEN/MMAC1/TEP1 promoter hypermethylation.
Sadeq V, Isar N, Manoochehr T
Med Oncol. 2011
PubMed ID: 20237868
-
Protein interactions of phosphatase and tensin homologue (PTEN) and its cancer-associated G20E mutant compared by using stable isotope labeling by amino acids in cell culture-based parallel affinity purification.
Gunaratne J, Goh MX, Swa HL, Lee FY, Sanford E, Wong LM, Hogue KA, Blackstock WP, Okumura K
J Biol Chem. 2011
PubMed ID: 21454687
-
BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition.
Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, Klemm L, Kweon SM, Nahar R, Braig M, Park E, Kim YM, Hofmann WK, Herzog S, Jumaa H, Koeffler HP, Yu JJ, Heisterkamp N, Graeber TG, Wu H, Ye BH, Melnick A, Müschen M
Nature. 2011
PubMed ID: 21593872
-
Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool.
Zhu HH, Ji K, Alderson N, He Z, Li S, Liu W, Zhang DE, Li L, Feng GS
Blood. 2011
PubMed ID: 21450902
-
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer.
Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S, Arora VK, Le C, Koutcher J, Scher H, Scardino PT, Rosen N, Sawyers CL
Cancer Cell. 2011
PubMed ID: 21575859
-
Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.
Nardella C, Lunardi A, Fedele G, Clohessy JG, Alimonti A, Kozma SC, Thomas G, Loda M, Pandolfi PP
Cancer Res. 2011
PubMed ID: 21444676
-
MicroRNA-21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN.
Wang ZX, Lu BB, Wang H, Cheng ZX, Yin YM
Arch Med Res. 2011
PubMed ID: 21820606
-
Frequency of germline PTEN mutations in differentiated thyroid cancer.
Nagy R, Ganapathi S, Comeras I, Peterson C, Orloff M, Porter K, Eng C, Ringel MD, Kloos RT
Thyroid. 2011
PubMed ID: 21417916
-
The protective effect of Cu/Zn-SOD against oxidative stress after PTEN deletion.
Yu C, Wang P, Li S, Wang X, Yu Z, Wang Z
Cancer Invest. 2011
PubMed ID: 21345072
-
Mutational analysis of the PTEN gene and its effects in esophageal squamous cell carcinoma.
Hou G, Lu Z, Liu M, Liu H, Xue L
Dig Dis Sci. 2011
PubMed ID: 21116717
-
PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models.
Ellwood-Yen K, Keilhack H, Kunii K, Dolinski B, Connor Y, Hu K, Nagashima K, O'Hare E, Erkul Y, Di Bacco A, Gargano D, Shomer NH, Angagaw M, Leccese E, Andrade P, Hurd M, Shin MK, Vogt TF, Northrup A, Bobkova EV, Kasibhatla S, Bronson RT, Scott ML, Draetta G, Richon V, Kohl N, Blume-Jensen P, Andersen JN, Kraus M
Cancer Res. 2011
PubMed ID: 21493594
-
CREB is a novel nuclear target of PTEN phosphatase.
Gu T, Zhang Z, Wang J, Guo J, Shen WH, Yin Y
Cancer Res. 2011
PubMed ID: 21385900
-
Immunohistochemical phospho tensin tumor suppressor gene staining patterns in endometrial hyperplasias: a 2-year study.
Rao AC, Arya G, Padma PJ
Indian J Pathol Microbiol. 2011
PubMed ID: 21623071
-
[Effects of oleanolic acid on apoptosis and PTEN expression of Jurkat cells].
Li Y, Liao AJ, Wu B, Pan MY, Liu ZG
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011
PubMed ID: 21518490
-
Conditional ablation of Pten in osteoprogenitors stimulates FGF signaling.
Guntur AR, Reinhold MI, Cuellar J, Naski MC
Development. 2011
PubMed ID: 21385768
-
Redox regulation of the tumor suppressor PTEN by glutaredoxin 5 and Ycp4.
Kim Y, Chay KO, Kim I, Song YB, Kim TY, Han SJ, Ahn Y, Cho SH, Hoe KL, Ahn BW, Huh WK, Lee SR
Biochem Biophys Res Commun. 2011
PubMed ID: 21371429
-
Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.
Ikegami D, Akiyama H, Suzuki A, Nakamura T, Nakano T, Yoshikawa H, Tsumaki N
Development. 2011
PubMed ID: 21367821
-
Regulation of lung endoderm progenitor cell behavior by miR302/367.
Tian Y, Zhang Y, Hurd L, Hannenhalli S, Liu F, Lu MM, Morrisey EE
Development. 2011
PubMed ID: 21350014
-
PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression.
Paraiso KH, Xiang Y, Rebecca VW, Abel EV, Chen YA, Munko AC, Wood E, Fedorenko IV, Sondak VK, Anderson AR, Ribas A, Palma MD, Nathanson KL, Koomen JM, Messina JL, Smalley KS
Cancer Res. 2011
PubMed ID: 21317224
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VHL mutations and dysregulation of pVHL- and PTEN-controlled pathways in multilocular cystic renal cell carcinoma.
von Teichman A, Compérat E, Behnke S, Storz M, Moch H, Schraml P
Mod Pathol. 2011
PubMed ID: 21151099
-
Association of PTEN polymorphisms with susceptibility to hepatocellular carcinoma in a Han Chinese population.
Ding J, Gao Y, Liu R, Xu F, Liu H
DNA Cell Biol. 2011
PubMed ID: 21138334
-
PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation.
Lee JJ, Kim BC, Park MJ, Lee YS, Kim YN, Lee BL, Lee JS
Cell Death Differ. 2011
PubMed ID: 21072054
-
Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins.
Yoshimi A, Goyama S, Watanabe-Okochi N, Yoshiki Y, Nannya Y, Nitta E, Arai S, Sato T, Shimabe M, Nakagawa M, Imai Y, Kitamura T, Kurokawa M
Blood. 2011
PubMed ID: 21289308
-
Pten knockdown in vivo increases excitatory drive onto dentate granule cells.
Luikart BW, Schnell E, Washburn EK, Bensen AL, Tovar KR, Westbrook GL
J Neurosci. 2011
PubMed ID: 21411674
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Detection of ERG gene rearrangements and PTEN deletions in unsuspected prostate cancer of the transition zone.
Liu S, Yoshimoto M, Trpkov K, Duan Q, Firszt M, Corcos J, Squire JA, Bismar TA
Cancer Biol Ther. 2011
PubMed ID: 21178509
-
The cerebrospinal fluid provides a proliferative niche for neural progenitor cells.
Lehtinen MK, Zappaterra MW, Chen X, Yang YJ, Hill AD, Lun M, Maynard T, Gonzalez D, Kim S, Ye P, D'Ercole AJ, Wong ET, LaMantia AS, Walsh CA
Neuron. 2011
PubMed ID: 21382550
-
Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain.
Chow LM, Endersby R, Zhu X, Rankin S, Qu C, Zhang J, Broniscer A, Ellison DW, Baker SJ
Cancer Cell. 2011
PubMed ID: 21397855
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DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, Schulick RD, Tang LH, Wolfgang CL, Choti MA, Velculescu VE, Diaz LA, Vogelstein B, Kinzler KW, Hruban RH, Papadopoulos N
Science. 2011
PubMed ID: 21252315
-
Estrogen receptor α induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells.
Noh EM, Lee YR, Chay KO, Chung EY, Jung SH, Kim JS, Youn HJ
Mol Med Report. 2011
PubMed ID: 21468554
-
Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk.
Biton M, Levin A, Slyper M, Alkalay I, Horwitz E, Mor H, Kredo-Russo S, Avnit-Sagi T, Cojocaru G, Zreik F, Bentwich Z, Poy MN, Artis D, Walker MD, Hornstein E, Pikarsky E, Ben-Neriah Y
Nat Immunol. 2011
PubMed ID: 21278735
-
Migration of renal tumor cells depends on dephosphorylation of Shc by PTEN.
Schneider E, Keppler R, Prawitt D, Steinwender C, Roos FC, Thüroff JW, Lausch E, Brenner W
Int J Oncol. 2011
PubMed ID: 21206972
-
PTEN status is related to cell proliferation and self-renewal independent of CD133 phenotype in the glioma-initiating cells.
Cheng RB, Ma RJ, Wang ZK, Yang SJ, Lin XZ, Rong H, Ma Y
Mol Cell Biochem. 2011
PubMed ID: 21110069
-
Pten in the breast tumor microenvironment: modeling tumor-stroma coevolution.
Wallace JA, Li F, Leone G, Ostrowski MC
Cancer Res. 2011
PubMed ID: 21303970
-
Role of microRNA-214-targeting phosphatase and tensin homolog in advanced glycation end product-induced apoptosis delay in monocytes.
Li LM, Hou DX, Guo YL, Yang JW, Liu Y, Zhang CY, Zen K
J Immunol. 2011
PubMed ID: 21228352
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Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency.
Tandon P, Gallo CA, Khatri S, Barger JF, Yepiskoposyan H, Plas DR
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21262837
-
[Expressions of FHIT and PTEN and their significance in prostate cancer].
Xiao Q, Gu XW, Jiang JX, Wang CM, Xu Q
Zhonghua Nan Ke Xue. 2011
PubMed ID: 21404710
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PTEN gene silencing prevents HIV-1 gp120(IIIB)-induced degeneration of striatal neurons.
Zou S, El-Hage N, Podhaizer EM, Knapp PE, Hauser KF
J Neurovirol. 2011
PubMed ID: 21234828
-
Clinical significance of tumor suppressor PTEN in colorectal carcinoma.
Hsu CP, Kao TY, Chang WL, Nieh S, Wang HL, Chung YC
Eur J Surg Oncol. 2011
PubMed ID: 21194879
-
Nuclear factor of activated T cells (NFAT) signaling regulates PTEN expression and intestinal cell differentiation.
Wang Q, Zhou Y, Jackson LN, Johnson SM, Chow CW, Evers BM
Mol Biol Cell. 2011
PubMed ID: 21148296
-
Endometrial cancer and genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2 within a population-based case-control study.
Lacey JV, Yang H, Gaudet MM, Dunning A, Lissowska J, Sherman ME, Peplonska B, Brinton LA, Healey CS, Ahmed S, Pharoah P, Easton D, Chanock S, Garcia-Closas M
Gynecol Oncol. 2011
PubMed ID: 21093899
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Constitutively expressed COX-2 in osteoblasts positively regulates Akt signal transduction via suppression of PTEN activity.
Li CJ, Chang JK, Wang GJ, Ho ML
Bone. 2011
PubMed ID: 20854947
-
Evidence for an hMSH3 defect in familial hamartomatous polyps.
Huang SC, Lee JK, Smith EJ, Doctolero RT, Tajima A, Beck SE, Weidner N, Carethers JM
Cancer. 2011
PubMed ID: 20845481
-
PTEN deletion prevents ischemic brain injury by activating the mTOR signaling pathway.
Shi GD, OuYang YP, Shi JG, Liu Y, Yuan W, Jia LS
Biochem Biophys Res Commun. 2011
PubMed ID: 21185267
-
Suppression of leukemia development caused by PTEN loss.
Guo W, Schubbert S, Chen JY, Valamehr B, Mosessian S, Shi H, Dang NH, Garcia C, Theodoro MF, Varella-Garcia M, Wu H
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21212363
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Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.
Song MS, Carracedo A, Salmena L, Song SJ, Egia A, Malumbres M, Pandolfi PP
Cell. 2011
PubMed ID: 21241890
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Involvement of miR-21 in resistance to daunorubicin by regulating PTEN expression in the leukaemia K562 cell line.
Bai H, Xu R, Cao Z, Wei D, Wang C
FEBS Lett. 2011
PubMed ID: 21187093
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Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells.
Arafa el-SA, Zhu Q, Shah ZI, Wani G, Barakat BM, Racoma I, El-Mahdy MA, Wani AA
Mutat Res. 2011
PubMed ID: 21040738
-
Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line.
Singh G, Odriozola L, Guan H, Kennedy CR, Chan AM
BMC Cancer. 2011
PubMed ID: 22103913
-
piggyBac transposon somatic mutagenesis with an activated reporter and tracker (PB-SMART) for genetic screens in mice.
Landrette SF, Cornett JC, Ni TK, Bosenberg MW, Xu T
PLoS One. 2011
PubMed ID: 22039523
-
Self-renewing Pten-/- TP53-/- protospheres produce metastatic adenocarcinoma cell lines with multipotent progenitor activity.
Abou-Kheir W, Hynes PG, Martin P, Yin JJ, Liu YN, Seng V, Lake R, Spurrier J, Kelly K
PLoS One. 2011
PubMed ID: 22022528
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Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression.
Fomchenko EI, Dougherty JD, Helmy KY, Katz AM, Pietras A, Brennan C, Huse JT, Milosevic A, Holland EC
PLoS One. 2011
PubMed ID: 21754979
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Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA
PLoS One. 2011
PubMed ID: 21731673
-
Mammalian target of rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN.
Tanwar PS, Zhang L, Kaneko-Tarui T, Curley MD, Taketo MM, Rani P, Roberts DJ, Teixeira JM
PLoS One. 2011
PubMed ID: 21695255
-
Genetic networks in the mouse retina: growth associated protein 43 and phosphatase tensin homolog network.
Freeman NE, Templeton JP, Orr WE, Lu L, Williams RW, Geisert EE
Mol Vis. 2011
PubMed ID: 21655357
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Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins.
Lima-Fernandes E, Enslen H, Camand E, Kotelevets L, Boularan C, Achour L, Benmerah A, Gibson LC, Baillie GS, Pitcher JA, Chastre E, Etienne-Manneville S, Marullo S, Scott MG
EMBO J. 2011
PubMed ID: 21642958
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Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype.
Lei L, Sonabend AM, Guarnieri P, Soderquist C, Ludwig T, Rosenfeld S, Bruce JN, Canoll P
PLoS One. 2011
PubMed ID: 21625383
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Recurrent chromosomal copy number alterations in sporadic chordomas.
Le LP, Nielsen GP, Rosenberg AE, Thomas D, Batten JM, Deshpande V, Schwab J, Duan Z, Xavier RJ, Hornicek FJ, Iafrate AJ
PLoS One. 2011
PubMed ID: 21602918
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Different conformations of phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) protein within the nucleus and cytoplasm of neurons.
Moncalero VL, Costanzo RV, Perandones C, Radrizzani M
PLoS One. 2011
PubMed ID: 21559530
-
α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells.
He L, Fan C, Kapoor A, Ingram AJ, Rybak AP, Austin RC, Dickhout J, Cutz JC, Scholey J, Tang D
Nat Commun. 2011
PubMed ID: 21556061
-
A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression.
Ni Z, Tang J, Cai Z, Yang W, Zhang L, Chen Q, Zhang L, Wang X
Respir Res. 2011
PubMed ID: 21489309
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Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation.
Kenerson HL, Yeh MM, Yeung RS
PLoS One. 2011
PubMed ID: 21479224
-
Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors.
Naguib A, Cooke JC, Happerfield L, Kerr L, Gay LJ, Luben RN, Ball RY, Mitrou PN, McTaggart A, Arends MJ
BMC Cancer. 2011
PubMed ID: 21473780
-
Opposite effects of HIV-1 p17 variants on PTEN activation and cell growth in B cells.
Giagulli C, Marsico S, Magiera AK, Bruno R, Caccuri F, Barone I, Fiorentini S, Andò S, Caruso A
PLoS One. 2011
PubMed ID: 21423810
-
Alternative HER/PTEN/Akt pathway activation in HPV positive and negative penile carcinomas.
Stankiewicz E, Prowse DM, Ng M, Cuzick J, Mesher D, Hiscock F, Lu YJ, Watkin N, Corbishley C, Lam W, Berney DM
PLoS One. 2011
PubMed ID: 21407808
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MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors.
Clegg NJ, Couto SS, Wongvipat J, Hieronymus H, Carver BS, Taylor BS, Ellwood-Yen K, Gerald WL, Sander C, Sawyers CL
PLoS One. 2011
PubMed ID: 21394210
-
Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog.
Lindgren AG, Natsuhara K, Tian E, Vincent JJ, Li X, Jiao J, Wu H, Banerjee U, Clark AT
PLoS One. 2011
PubMed ID: 21304588
-
Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder.
Shorning BY, Griffiths D, Clarke AR
PLoS One. 2011
PubMed ID: 21283818
-
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Coalterations of p53 and PTEN tumor suppressor genes in non-small cell lung carcinoma patients.
Andjelkovic T, Bankovic J, Stojsic J, Milinkovic V, Podolski-Renic A, Ruzdijic S, Tanic N
Transl Res. 2011
PubMed ID: 21146147
-
Loss of PTEN permits CXCR4-mediated tumorigenesis through ERK1/2 in prostate cancer cells.
Chetram MA, Odero-Marah V, Hinton CV
Mol Cancer Res. 2011
PubMed ID: 21076047
-
How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance.
Wullschleger S, Sakamoto K, Johnstone L, Duce S, Fleming S, Alessi DR
Dis Model Mech. 2011
PubMed ID: 20959631
-
Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53.
He X, Ni Y, Wang Y, Romigh T, Eng C
Hum Mol Genet. 2011
PubMed ID: 20926450
-
Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome.
Bennett KL, Mester J, Eng C
JAMA. 2010
PubMed ID: 21177507
-
Regulation of PTEN stability and activity by Plk3.
Xu D, Yao Y, Jiang X, Lu L, Dai W
J Biol Chem. 2010
PubMed ID: 20940307
-
PTEN suppression promotes neurite development exclusively in differentiating PC12 cells via PI3-kinase and MAP kinase signaling.
Jia L, Ji S, Maillet JC, Zhang X
J Cell Biochem. 2010
PubMed ID: 20830745
-
Impact of KRAS mutation and PTEN expression on cetuximab-treated colorectal cancer.
Li FH, Shen L, Li ZH, Luo HY, Qiu MZ, Zhang HZ, Li YH, Xu RH
World J Gastroenterol. 2010
PubMed ID: 21155011
-
Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol.
Radulescu S, Ridgway RA, Appleton P, Kroboth K, Patel S, Woodgett J, Taylor S, Nathke IS, Sansom OJ
Oncogene. 2010
PubMed ID: 20729907
-
Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation.
Lukacs RU, Memarzadeh S, Wu H, Witte ON
Cell Stem Cell. 2010
PubMed ID: 21112563
-
MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration.
Sarver AL, Li L, Subramanian S
Cancer Res. 2010
PubMed ID: 21118966
-
Role of DJ-1-induced PTEN down-regulation in migration and invasion of human glioma cells.
Fang M, Zhong XY, Du B, Lin CL, Luo F, Tang LJ, Chen J
Chin J Cancer. 2010
PubMed ID: 21114918
-
The PTEN tumor suppressor inhibits human airway smooth muscle cell migration.
Lan H, Zhong H, Gao Y, Ren D, Chen L, Zhang D, Lai W, Xu J, Luo Y
Int J Mol Med. 2010
PubMed ID: 21042784
-
MicroRNA-21 promotes the cell proliferation, invasion and migration abilities in ovarian epithelial carcinomas through inhibiting the expression of PTEN protein.
Lou Y, Yang X, Wang F, Cui Z, Huang Y
Int J Mol Med. 2010
PubMed ID: 21042775
-
Cellular response to cetuximab in PTEN-silenced head and neck squamous cell carcinoma cell line.
Mriouah J, Boura C, Pinel S, Chretien AS, Fifre A, Merlin JL, Faivre B
Int J Oncol. 2010
PubMed ID: 21042725
-
Characterizing the contribution of stem/progenitor cells to tumorigenesis in the Pten-/-TP53-/- prostate cancer model.
Abou-Kheir WG, Hynes PG, Martin PL, Pierce R, Kelly K
Stem Cells. 2010
PubMed ID: 20936707
-
Anti-inflammatory properties of the PI3K pathway are mediated by IL-10/DUSP regulation.
Günzl P, Bauer K, Hainzl E, Matt U, Dillinger B, Mahr B, Knapp S, Binder BR, Schabbauer G
J Leukoc Biol. 2010
PubMed ID: 20884649
-
Polymorphisms in promoter sequences of the p15 ( INK4B ) and PTEN genes of normal Japanese individuals.
Ohsaka Y, Yogosawa S, Nakanishi R, Sakai T, Nishino H
Biochem Genet. 2010
PubMed ID: 20862607
-
Decidual PTEN expression is required for trophoblast invasion in the mouse.
Laguë MN, Detmar J, Paquet M, Boyer A, Richards JS, Adamson SL, Boerboom D
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 20858757
-
Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2.
Galicia VA, He L, Dang H, Kanel G, Vendryes C, French BA, Zeng N, Bayan JA, Ding W, Wang KS, French S, Birnbaum MJ, Rountree CB, Stiles BL
Gastroenterology. 2010
PubMed ID: 20837017
-
Implications for immunotherapy of tumor-mediated T-cell apoptosis associated with loss of the tumor suppressor PTEN in glioblastoma.
Waldron JS, Yang I, Han S, Tihan T, Sughrue ME, Mills SA, Pieper RO, Parsa AT
J Clin Neurosci. 2010
PubMed ID: 20822910
-
Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway.
Bai Z, Zhang Z, Ye Y, Wang S
Cell Biol Int. 2010
PubMed ID: 20718712
-
Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers.
Heald B, Mester J, Rybicki L, Orloff MS, Burke CA, Eng C
Gastroenterology. 2010
PubMed ID: 20600018
-
Cowden syndrome.
Farooq A, Walker LJ, Bowling J, Audisio RA
Cancer Treat Rev. 2010
PubMed ID: 20580873
-
Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis.
Nogueira C, Kim KH, Sung H, Paraiso KH, Dannenberg JH, Bosenberg M, Chin L, Kim M
Oncogene. 2010
PubMed ID: 20711233
-
Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion.
Kurimoto T, Yin Y, Omura K, Gilbert HY, Kim D, Cen LP, Moko L, Kügler S, Benowitz LI
J Neurosci. 2010
PubMed ID: 21084621
-
ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons.
Song W, Volosin M, Cragnolini AB, Hempstead BL, Friedman WJ
J Neurosci. 2010
PubMed ID: 21084616
-
Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma.
Diegel CR, Cho KR, El-Naggar AK, Williams BO, Lindvall C
Cancer Res. 2010
PubMed ID: 21062985
-
Phosphatase and tensin homolog deleted on chromosome 10 regulates sensory cell proliferation and differentiation of hair bundles in the mammalian cochlea.
Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Hossain MA, Suzuki A, Holley MC, Tokuda M
Neuroscience. 2010
PubMed ID: 20727948
-
mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion.
Lee JY, Nakada D, Yilmaz OH, Tothova Z, Joseph NM, Lim MS, Gilliland DG, Morrison SJ
Cell Stem Cell. 2010
PubMed ID: 21040901
-
Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations.
Yamamoto C, Basaki Y, Kawahara A, Nakashima K, Kage M, Izumi H, Kohno K, Uramoto H, Yasumoto K, Kuwano M, Ono M
Cancer Res. 2010
PubMed ID: 20959484
-
Somatic mutations of signaling genes in non-small-cell lung cancer.
Sanders HR, Albitar M
Cancer Genet Cytogenet. 2010
PubMed ID: 20951313
-
Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis.
Zheng W, Gorre N, Shen Y, Noda T, Ogawa W, Lundin E, Liu K
EMBO Rep. 2010
PubMed ID: 20930845
-
Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice.
Huang SK, Fisher AS, Scruggs AM, White ES, Hogaboam CM, Richardson BC, Peters-Golden M
Am J Pathol. 2010
PubMed ID: 20889571
-
Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas.
Amodio N, Scrima M, Palaia L, Salman AN, Quintiero A, Franco R, Botti G, Pirozzi P, Rocco G, De Rosa N, Viglietto G
Am J Pathol. 2010
PubMed ID: 20889565
-
Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers.
Lee SY, Kim MJ, Jin G, Yoo SS, Park JY, Choi JE, Jeon HS, Cho S, Lee EB, Cha SI, Park TI, Kim CH, Jung TH, Park JY
J Thorac Oncol. 2010
PubMed ID: 20881644
-
erbB2 gene silencing and its effect on PTEN in SACC-83 salivary adenoid cystic carcinoma cells.
Liu X, Zhang Y, Ren W, Rao G
Oncol Rep. 2010
PubMed ID: 20878123
-
PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells.
Tsoyi K, Jang HJ, Nizamutdinova IT, Park K, Kim YM, Kim HJ, Seo HG, Lee JH, Chang KC
Atherosclerosis. 2010
PubMed ID: 20864106
-
Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination.
Harrington EP, Zhao C, Fancy SP, Kaing S, Franklin RJ, Rowitch DH
Ann Neurol. 2010
PubMed ID: 20853437
-
Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP.
Kim S, Huang W, Mottillo EP, Sohail A, Ham YA, Conley-Lacomb MK, Kim CJ, Tzivion G, Kim HR, Wang S, Chen YQ, Fridman R
Biochim Biophys Acta. 2010
PubMed ID: 20620173
-
Head circumference in the clinical detection of PTEN hamartoma tumor syndrome in a clinic population at high-risk of breast cancer.
Shiovitz S, Everett J, Huang SC, Orloff MS, Eng C, Gruber SB
Breast Cancer Res Treat. 2010
PubMed ID: 20349131
-
Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling.
Sathaliyawala T, O'Gorman WE, Greter M, Bogunovic M, Konjufca V, Hou ZE, Nolan GP, Miller MJ, Merad M, Reizis B
Immunity. 2010
PubMed ID: 20933441
-
Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to gefitinib in HCC827 NSCLC cells.
Kim SM, Kim JS, Kim JH, Yun CO, Kim EM, Kim HK, Solca F, Choi SY, Cho BC
Cancer Lett. 2010
PubMed ID: 20444542
-
Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases.
Miletic AV, Anzelon-Mills AN, Mills DM, Omori SA, Pedersen IM, Shin DM, Ravetch JV, Bolland S, Morse HC, Rickert RC
J Exp Med. 2010
PubMed ID: 20956547
-
A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesis.
Kini V, Chavez A, Mehta D
J Biol Chem. 2010
PubMed ID: 20705603
-
HBx-induced reactive oxygen species activates hepatocellular carcinogenesis via dysregulation of PTEN/Akt pathway.
Ha HL, Yu DY
World J Gastroenterol. 2010
PubMed ID: 20954279
-
Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females.
Antico-Arciuch VG, Dima M, Liao XH, Refetoff S, Di Cristofano A
Oncogene. 2010
PubMed ID: 20676139
-
[Expression of phosphatase and tensin homolog in lower rectal cancer on neoadjuvant chemoradiotherapy].
Jin JH, Rong YX, Wang F, Xu XY, Lu WB, Li XW, Deng JZ, Zhang H, Xu XZ, Xue ZX
Zhonghua Yi Xue Za Zhi. 2010
PubMed ID: 21162897
-
Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells.
Park J, Oh Y, Yoo L, Jung MS, Song WJ, Lee SH, Seo H, Chung KC
J Biol Chem. 2010
PubMed ID: 20696760
-
Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia.
Shehata M, Schnabl S, Demirtas D, Hilgarth M, Hubmann R, Ponath E, Badrnya S, Lehner C, Hoelbl A, Duechler M, Gaiger A, Zielinski C, Schwarzmeier JD, Jaeger U
Blood. 2010
PubMed ID: 20576813
-
PTEN regulates collagen-induced platelet activation.
Weng Z, Li D, Zhang L, Chen J, Ruan C, Chen G, Gartner TK, Liu J
Blood. 2010
PubMed ID: 20554973
-
Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium.
Memarzadeh S, Zong Y, Janzen DM, Goldstein AS, Cheng D, Kurita T, Schafenacker AM, Huang J, Witte ON
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20855612
-
[Correlation of expression of PTEN with AKT phosphorylation level in leukemia cells].
Zhang YY, Liu T, Meng WT
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010
PubMed ID: 21129241
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Endocervical-like (Müllerian) mucinous borderline tumours of the ovary are frequently associated with the KRAS mutation.
Kim KR, Choi J, Hwang JE, Baik YA, Shim JY, Kim YM, Robboy SJ
Histopathology. 2010
PubMed ID: 20955384
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Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction.
Rolf J, Bell SE, Kovesdi D, Janas ML, Soond DR, Webb LM, Santinelli S, Saunders T, Hebeis B, Killeen N, Okkenhaug K, Turner M
J Immunol. 2010
PubMed ID: 20826752
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PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.
Esteva FJ, Guo H, Zhang S, Santa-Maria C, Stone S, Lanchbury JS, Sahin AA, Hortobagyi GN, Yu D
Am J Pathol. 2010
PubMed ID: 20813970
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A mutant form of PTEN linked to autism.
Redfern RE, Daou MC, Li L, Munson M, Gericke A, Ross AH
Protein Sci. 2010
PubMed ID: 20718038
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An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K
Hum Genet. 2010
PubMed ID: 20677014
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Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
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Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway.
White ES, Sagana RL, Booth AJ, Yan M, Cornett AM, Bloomheart CA, Tsui JL, Wilke CA, Moore BB, Ritzenthaler JD, Roman J, Muro AF
Exp Cell Res. 2010
PubMed ID: 20615404
-
Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival.
Hand TW, Cui W, Jung YW, Sefik E, Joshi NS, Chandele A, Liu Y, Kaech SM
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20823247
-
Cancer-associated fibroblasts enhance the gland-forming capability of prostate cancer stem cells.
Liao CP, Adisetiyo H, Liang M, Roy-Burman P
Cancer Res. 2010
PubMed ID: 20807814
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PTEN loss accelerates KrasG12D-induced pancreatic cancer development.
Hill R, Calvopina JH, Kim C, Wang Y, Dawson DW, Donahue TR, Dry S, Wu H
Cancer Res. 2010
PubMed ID: 20807812
-
beta-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.
Ahmad I, Morton JP, Singh LB, Radulescu SM, Ridgway RA, Patel S, Woodgett J, Winton DJ, Taketo MM, Wu XR, Leung HY, Sansom OJ
Oncogene. 2010
PubMed ID: 20818428
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Semaphorin 4D/Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons.
Oinuma I, Ito Y, Katoh H, Negishi M
J Biol Chem. 2010
PubMed ID: 20610402
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Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases.
Mistafa O, Ghalali A, Kadekar S, Högberg J, Stenius U
J Biol Chem. 2010
PubMed ID: 20605778
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[PTEN gene in triple-negative breast cancer].
Karseladze AI, Kulevich EE, Karseladze DA, Poddubnaia IV
Arkh Patol. 2010
PubMed ID: 21313761
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Immunoexpression and clinical significance of the PTEN and MLH1 proteins in endometrial carcinomas.
Bąkiewicz A, Michalak J, Sporny S
Pol J Pathol. 2010
PubMed ID: 21290340
-
Overexpression of the Parkinson disease protein DJ-1 and its regulator PTEN in gestational trophoblastic disease.
Zhang HJ, Siu MK, Jiang LL, Mak VC, Ngan HY, Cheung AN
Int J Gynecol Pathol. 2010
PubMed ID: 20736773
-
Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation.
Molina JR, Morales FC, Hayashi Y, Aldape KD, Georgescu MM
Cancer Res. 2010
PubMed ID: 20736378
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Endothelial cells promote neural stem cell proliferation and differentiation associated with VEGF activated Notch and Pten signaling.
Sun J, Zhou W, Ma D, Yang Y
Dev Dyn. 2010
PubMed ID: 20730910
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PTEN deletion enhances the regenerative ability of adult corticospinal neurons.
Liu K, Lu Y, Lee JK, Samara R, Willenberg R, Sears-Kraxberger I, Tedeschi A, Park KK, Jin D, Cai B, Xu B, Connolly L, Steward O, Zheng B, He Z
Nat Neurosci. 2010
PubMed ID: 20694004
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Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development.
Tan Y, You H, Coffey FJ, Wiest DL, Testa JR
Genesis. 2010
PubMed ID: 20665729
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PTEN sensitizes MDA-MB-468 cells to inhibition of MEK/Erk signaling for the blockade of cell proliferation.
Jang K, Kim M, Seo HS, Shin I
Oncol Rep. 2010
PubMed ID: 20664988
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PI(3)king apart PTEN's role in cancer.
Zhang S, Yu D
Clin Cancer Res. 2010
PubMed ID: 20622047
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Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.
Slattery ML, Herrick JS, Lundgreen A, Fitzpatrick FA, Curtin K, Wolff RK
Carcinogenesis. 2010
PubMed ID: 20622004
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PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice.
Zheng T, Meng X, Wang J, Chen X, Yin D, Liang Y, Song X, Pan S, Jiang H, Liu L
J Cell Biochem. 2010
PubMed ID: 20506484
-
Evaluation of PTEN and Mcl-1 expressions in NSCLC expressing wild-type or mutated EGFR.
Cetin Z, Ozbilim G, Erdogan A, Luleci G, Karauzum SB
Med Oncol. 2010
PubMed ID: 19763916
-
STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer.
Iliopoulos D, Jaeger SA, Hirsch HA, Bulyk ML, Struhl K
Mol Cell. 2010
PubMed ID: 20797623
-
Redox regulation of the tumor suppressor PTEN by glutathione.
Kim Y, Song YB, Kim TY, Kim I, Han SJ, Ahn Y, Cho SH, Choi CY, Chay KO, Yang SY, Ahn BW, Huh WK, Lee SR
FEBS Lett. 2010
PubMed ID: 20637195
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PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression.
Jurado S, Benoist M, Lario A, Knafo S, Petrok CN, Esteban JA
EMBO J. 2010
PubMed ID: 20628354
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PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons.
Ning K, Drepper C, Valori CF, Ahsan M, Wyles M, Higginbottom A, Herrmann T, Shaw P, Azzouz M, Sendtner M
Hum Mol Genet. 2010
PubMed ID: 20525971
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Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.
Ueda T, Sasaki M, Elia AJ, Chio II, Hamada K, Fukunaga R, Mak TW
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20679220
-
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.
Furic L, Rong L, Larsson O, Koumakpayi IH, Yoshida K, Brueschke A, Petroulakis E, Robichaud N, Pollak M, Gaboury LA, Pandolfi PP, Saad F, Sonenberg N
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20679199
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[Nedd4/PTEN in axonal branching].
Strochlic L
Med Sci (Paris). 2010
PubMed ID: 20819705
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Joint loss of PAX2 and PTEN expression in endometrial precancers and cancer.
Monte NM, Webster KA, Neuberg D, Dressler GR, Mutter GL
Cancer Res. 2010
PubMed ID: 20631067
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Loss of PTEN/MMAC1 activity is a rare and late event in the pathogenesis of nephroblastomas.
Grill C, Guelly C, Ebner B, Leuschner I, Hauser-Kronberger C, Hoefler G, Guertl B
Hum Pathol. 2010
PubMed ID: 20381115
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Costimulation-dependent expression of microRNA-214 increases the ability of T cells to proliferate by targeting Pten.
Jindra PT, Bagley J, Godwin JG, Iacomini J
J Immunol. 2010
PubMed ID: 20548023
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Role of phosphatase and tensin homolog in the development of the mammalian auditory system.
Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Suzuki A, Holley M, Tokuda M
Neuroreport. 2010
PubMed ID: 20531234
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PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons.
Christie KJ, Webber CA, Martinez JA, Singh B, Zochodne DW
J Neurosci. 2010
PubMed ID: 20610765
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The p85beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling.
He J, de la Monte S, Wands JR
Biochem Biophys Res Commun. 2010
PubMed ID: 20515662
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[Expressions of bFGF and PTEN in cervical carcinoma and their clinical significance].
Luo CF, Hong HL, Lu YL, Wang H, Liu MQ
Zhonghua Zhong Liu Za Zhi. 2010
PubMed ID: 21029699
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[Expression and clinical significance of mTOR and PTEN in non-small cell lung cancer].
Wang L, Xu S, Yue W, Zhao X, Zhang L, Wang Y
Zhongguo Fei Ai Za Zhi. 2010
PubMed ID: 20673489
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N-cadherin can structurally substitute for E-cadherin during intestinal development but leads to polyp formation.
Libusova L, Stemmler MP, Hierholzer A, Schwarz H, Kemler R
Development. 2010
PubMed ID: 20534673
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PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.
McEllin B, Camacho CV, Mukherjee B, Hahm B, Tomimatsu N, Bachoo RM, Burma S
Cancer Res. 2010
PubMed ID: 20530668
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Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice.
Liu X, Karnell JL, Yin B, Zhang R, Zhang J, Li P, Choi Y, Maltzman JS, Pear WS, Bassing CH, Turka LA
J Clin Invest. 2010
PubMed ID: 20516645
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Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway.
Wen YG, Wang Q, Zhou CZ, Qiu GQ, Peng ZH, Tang HM
Oncol Rep. 2010
PubMed ID: 20514448
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Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia.
Schabbauer G, Matt U, Günzl P, Warszawska J, Furtner T, Hainzl E, Elbau I, Mesteri I, Doninger B, Binder BR, Knapp S
J Immunol. 2010
PubMed ID: 20505137
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PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.
Feng Q, Di R, Tao F, Chang Z, Lu S, Fan W, Shan C, Li X, Yang Z
Mol Cell Biol. 2010
PubMed ID: 20457809
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A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
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PTEN regulates angiogenesis and VEGF expression through phosphatase-dependent and -independent mechanisms in HepG2 cells.
Tian T, Nan KJ, Wang SH, Liang X, Lu CX, Guo H, Wang WJ, Ruan ZP
Carcinogenesis. 2010
PubMed ID: 20430845
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The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression.
Kim TH, Franco HL, Jung SY, Qin J, Broaddus RR, Lydon JP, Jeong JW
Oncogene. 2010
PubMed ID: 20418913
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Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels.
Bu S, Asano Y, Bujor A, Highland K, Hant F, Trojanowska M
Arthritis Rheum. 2010
PubMed ID: 20309867
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Inhibition of mTORC1 signaling reduces tumor growth but does not prevent cancer progression in a mouse model of thyroid cancer.
Guigon CJ, Fozzatti L, Lu C, Willingham MC, Cheng SY
Carcinogenesis. 2010
PubMed ID: 20299527
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Differential sensitivity of human endometrial carcinoma cells with different PTEN expression to mitogen-activated protein kinase signaling inhibits and implications for therapy.
Xiao L, Yang YB, Li XM, Xu CF, Li T, Wang XY
J Cancer Res Clin Oncol. 2010
PubMed ID: 20087603
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PTEN and TRP53 independently suppress Nanog expression in spermatogonial stem cells.
Kuijk EW, van Mil A, Brinkhof B, Penning LC, Colenbrander B, Roelen BA
Stem Cells Dev. 2010
PubMed ID: 19845468
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Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination.
Goebbels S, Oltrogge JH, Kemper R, Heilmann I, Bormuth I, Wolfer S, Wichert SP, Möbius W, Liu X, Lappe-Siefke C, Rossner MJ, Groszer M, Suter U, Frahm J, Boretius S, Nave KA
J Neurosci. 2010
PubMed ID: 20592216
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PTEN genomic deletion is an early event associated with ERG gene rearrangements in prostate cancer.
Bismar TA, Yoshimoto M, Vollmer RT, Duan Q, Firszt M, Corcos J, Squire JA
BJU Int. 2010
PubMed ID: 20590547
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Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.
Mund T, Pelham HR
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20534535
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Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination.
Cotter L, Ozçelik M, Jacob C, Pereira JA, Locher V, Baumann R, Relvas JB, Suter U, Tricaud N
Science. 2010
PubMed ID: 20448149
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An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation.
Fu CT, Zhu KY, Mi JQ, Liu YF, Murray ST, Fu YF, Ren CG, Dong ZW, Liu YJ, Dong M, Jin Y, Chen Y, Deng M, Zhang W, Chen B, Breslin P, Chen SJ, Chen Z, Becker MW, Zhu J, Zhang JW, Liu TX
Blood. 2010
PubMed ID: 20371743
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[Effects of laminarin sulphate on the expressions of PTEN and P271kip1 in prostate cancer PC-3 cells].
Zou MC, Cui FL, Sheng YQ, Qiu Z
Zhonghua Nan Ke Xue. 2010
PubMed ID: 20608352
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Confirmation study of PTEN mutations among individuals with autism or developmental delays/mental retardation and macrocephaly.
McBride KL, Varga EA, Pastore MT, Prior TW, Manickam K, Atkin JF, Herman GE
Autism Res. 2010
PubMed ID: 20533527
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IMP3 distinguishes uterine serous carcinoma from endometrial endometrioid adenocarcinoma.
Mhawech-Fauceglia P, Herrmann FR, Rai H, Tchabo N, Lele S, Izevbaye I, Odunsi K, Cheney RT
Am J Clin Pathol. 2010
PubMed ID: 20472848
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Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis.
Xia H, Khalil W, Kahm J, Jessurun J, Kleidon J, Henke CA
Am J Pathol. 2010
PubMed ID: 20395445
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Decrease in PTEN and increase in Akt expression and neuron size in aged rat spinal cord.
Rodrigues de Amorim MA, Garcia-Segura LM, Goya RG, Portiansky EL
Exp Gerontol. 2010
PubMed ID: 20347952
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PTEN inhibition improves muscle regeneration in mice fed a high-fat diet.
Hu Z, Wang H, Lee IH, Modi S, Wang X, Du J, Mitch WE
Diabetes. 2010
PubMed ID: 20200318
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Mutational and immunohistochemical study of the PI3K/Akt pathway in papillary thyroid carcinoma in Greece.
Sozopoulos E, Litsiou H, Voutsinas G, Mitsiades N, Anagnostakis N, Tseva T, Patsouris E, Tseleni-Balafouta S
Endocr Pathol. 2010
PubMed ID: 20186503
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PTEN attenuates PIP3/Akt signaling in the cochlea of the aging CBA/J mouse.
Sha SH, Chen FQ, Schacht J
Hear Res. 2010
PubMed ID: 19761823
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CD95 promotes tumour growth.
Chen L, Park SM, Tumanov AV, Hau A, Sawada K, Feig C, Turner JR, Fu YX, Romero IL, Lengyel E, Peter ME
Nature. 2010
PubMed ID: 20505730
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Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits.
Jiang X, Chen S, Asara JM, Balk SP
J Biol Chem. 2010
PubMed ID: 20231295
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E17K substitution in AKT1 in prostate cancer.
Boormans JL, Korsten H, Ziel-van der Made AC, van Leenders GJ, Verhagen PC, Trapman J
Br J Cancer. 2010
PubMed ID: 20407443
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Phosphatase and tensin homolog gene inhibits the effect induced by gonadotropin-releasing hormone subtypes in human endometrial carcinoma cells.
Zhao LJ, Liu N, Li XP, Wang JL, Wei LH
Chin Med J (Engl). 2010
PubMed ID: 20529558
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PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapy.
Pu X, Hildebrandt MA, Lu C, Lin J, Stewart DJ, Ye Y, Gu J, Spitz MR, Wu X
Lung Cancer. 2010
PubMed ID: 20447721
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[The expression and role of PTEN in doxorubicin induced gastric cancer cell apoptosis].
Fu XQ, Yu JP, Luo HS, Yu HG
Zhonghua Nei Ke Za Zhi. 2010
PubMed ID: 20646419
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In situ vaccination combined with androgen ablation and regulatory T-cell depletion reduces castration-resistant tumor burden in prostate-specific pten knockout mice.
Akins EJ, Moore ML, Tang S, Willingham MC, Tooze JA, Dubey P
Cancer Res. 2010
PubMed ID: 20406970
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Subtle variations in Pten dose determine cancer susceptibility.
Alimonti A, Carracedo A, Clohessy JG, Trotman LC, Nardella C, Egia A, Salmena L, Sampieri K, Haveman WJ, Brogi E, Richardson AL, Zhang J, Pandolfi PP
Nat Genet. 2010
PubMed ID: 20400965
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Altered expression of Akt signaling pathway parameters in prostate needle biopsies derived from benign, adjacent and cancerous tissue.
Waalkes S, Simon P, Hennenlotter J, Knapp J, Tezval H, Serth J, Stenzl A, Kuczyk MA, Merseburger AS
Oncol Rep. 2010
PubMed ID: 20372838
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Preservation of GABAA receptor function by PTEN inhibition protects against neuronal death in ischemic stroke.
Liu B, Li L, Zhang Q, Chang N, Wang D, Shan Y, Li L, Wang H, Feng H, Zhang L, Brann DW, Wan Q
Stroke. 2010
PubMed ID: 20360540
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The critical role of AKT2 in hepatic steatosis induced by PTEN loss.
He L, Hou X, Kanel G, Zeng N, Galicia V, Wang Y, Yang J, Wu H, Birnbaum MJ, Stiles BL
Am J Pathol. 2010
PubMed ID: 20348245
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Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN.
Yu H, Li Y, Gao C, Fabien L, Jia Y, Lu J, Silberstein LE, Pinkus GS, Ye K, Chai L, Luo HR
Leukemia. 2010
PubMed ID: 20220776
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Molecular alterations of EGFR and PTEN in prostate cancer: association with high-grade and advanced-stage carcinomas.
de Muga S, Hernández S, Agell L, Salido M, Juanpere N, Lorenzo M, Lorente JA, Serrano S, Lloreta J
Mod Pathol. 2010
PubMed ID: 20208477
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Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.
Furgeson SB, Simpson PA, Park I, Vanputten V, Horita H, Kontos CD, Nemenoff RA, Weiser-Evans MC
Cardiovasc Res. 2010
PubMed ID: 20051384
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IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells.
Ma J, Sawai H, Matsuo Y, Ochi N, Yasuda A, Takahashi H, Wakasugi T, Funahashi H, Sato M, Takeyama H
J Surg Res. 2010
PubMed ID: 19560785
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Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.
Maccario H, Perera NM, Gray A, Downes CP, Leslie NR
J Biol Chem. 2010
PubMed ID: 20177066
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Attenuation of PI3K/Akt-mediated tumorigenic signals through PTEN activation by DNA vaccine-induced anti-ErbB2 antibodies.
Porzia A, Lanzardo S, Citti A, Cavallo F, Forni G, Santoni A, Galandrini R, Paolini R
J Immunol. 2010
PubMed ID: 20220087
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17betaE2 promotes cell proliferation in endometriosis by decreasing PTEN via NFkappaB-dependent pathway.
Zhang H, Zhao X, Liu S, Li J, Wen Z, Li M
Mol Cell Endocrinol. 2010
PubMed ID: 19932734
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Immunosuppressive cyclosporin A activates AKT in keratinocytes through PTEN suppression: implications in skin carcinogenesis.
Han W, Ming M, He TC, He YY
J Biol Chem. 2010
PubMed ID: 20154081
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The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.
Vivanco I, Rohle D, Versele M, Iwanami A, Kuga D, Oldrini B, Tanaka K, Dang J, Kubek S, Palaskas N, Hsueh T, Evans M, Mulholland D, Wolle D, Rajasekaran S, Rajasekaran A, Liau LM, Cloughesy TF, Dikic I, Brennan C, Wu H, Mischel PS, Perera T, Mellinghoff IK
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20308550
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PTEN silencing reverses aging-related impairment of angiogenesis in microvascular endothelial cells.
Tarnawski AS, Pai R, Tanigawa T, Matysiak-Budnik T, Ahluwalia A
Biochem Biophys Res Commun. 2010
PubMed ID: 20193662
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Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis.
Cipriano R, Patton JT, Mayo LD, Jackson MW
Cell Cycle. 2010
PubMed ID: 20305378
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17beta-estradiol induces up-regulation of PTEN and PPARgamma in leiomyoma cells, but not in normal cells.
Jeong YJ, Noh EM, Lee YR, Yu HN, Jang KY, Lee SJ, Kim J, Kim JS
Int J Oncol. 2010
PubMed ID: 20198337
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PTEN/pAkt/p53 signaling pathway correlates with the radioresponse of non-small cell lung cancer.
Jung IL, Kang HJ, Kim KC, Kim IG
Int J Mol Med. 2010
PubMed ID: 20198299
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Evaluation of the mTOR pathway in ocular (uvea and conjunctiva) melanoma.
Pópulo H, Soares P, Rocha AS, Silva P, Lopes JM
Melanoma Res. 2010
PubMed ID: 20173664
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Complicated biallelic inactivation of Pten in radiation-induced mouse thymic lymphomas.
Yamaguchi Y, Takabatake T, Kakinuma S, Amasaki Y, Nishimura M, Imaoka T, Yamauchi K, Shang Y, Miyoshi-Imamura T, Nogawa H, Kobayashi Y, Shimada Y
Mutat Res. 2010
PubMed ID: 20060398
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Identification of novel PTEN-binding partners: PTEN interaction with fatty acid binding protein FABP4.
Gorbenko O, Panayotou G, Zhyvoloup A, Volkova D, Gout I, Filonenko V
Mol Cell Biochem. 2010
PubMed ID: 19911253
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PTEN, RASSF1 and DAPK site-specific hypermethylation and outcome in surgically treated stage I and II nonsmall cell lung cancer patients.
Buckingham L, Penfield Faber L, Kim A, Liptay M, Barger C, Basu S, Fidler M, Walters K, Bonomi P, Coon J
Int J Cancer. 2010
PubMed ID: 19795445
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Loss of function of PTEN alters the relationship between glucose concentration and cell proliferation, increases glycolysis, and sensitizes cells to 2-deoxyglucose.
Blouin MJ, Zhao Y, Zakikhani M, Algire C, Piura E, Pollak M
Cancer Lett. 2010
PubMed ID: 19744772
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Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc.
Kwak YD, Wang B, Pan W, Xu H, Jiang X, Liao FF
J Biol Chem. 2010
PubMed ID: 20100827
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Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.
Chagpar RB, Links PH, Pastor MC, Furber LA, Hawrysh AD, Chamberlain MD, Anderson DH
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20212113
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PTEN mutation spectrum in breast cancers and breast hyperplasia.
Yang J, Ren Y, Wang L, Li B, Chen Y, Zhao W, Xu W, Li T, Dai F
J Cancer Res Clin Oncol. 2010
PubMed ID: 20300775
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Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.
Lin HK, Chen Z, Wang G, Nardella C, Lee SW, Chan CH, Yang WL, Wang J, Egia A, Nakayama KI, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP
Nature. 2010
PubMed ID: 20237562
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Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves.
Ozçelik M, Cotter L, Jacob C, Pereira JA, Relvas JB, Suter U, Tricaud N
J Neurosci. 2010
PubMed ID: 20237282
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Leptin regulates AMPA receptor trafficking via PTEN inhibition.
Moult PR, Cross A, Santos SD, Carvalho AL, Lindsay Y, Connolly CN, Irving AJ, Leslie NR, Harvey J
J Neurosci. 2010
PubMed ID: 20237279
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Allele-specific tumor spectrum in pten knockin mice.
Wang H, Karikomi M, Naidu S, Rajmohan R, Caserta E, Chen HZ, Rawahneh M, Moffitt J, Stephens JA, Fernandez SA, Weinstein M, Wang D, Sadee W, La Perle K, Stromberg P, Rosol TJ, Eng C, Ostrowski MC, Leone G
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20194734
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ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.
Vemula S, Shi J, Hanneman P, Wei L, Kapur R
Blood. 2010
PubMed ID: 20008297
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Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486.
Small EM, O'Rourke JR, Moresi V, Sutherland LB, McAnally J, Gerard RD, Richardson JA, Olson EN
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20142475
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Mutations of PTEN gene in gliomas correlate to tumor differentiation and short-term survival rate.
Yang Y, Shao N, Luo G, Li L, Zheng L, Nilsson-Ehle P, Xu N
Anticancer Res. 2010
PubMed ID: 20393024
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VHL and PTEN loss coordinate to promote mouse liver vascular lesions.
Chen S, Sanford CA, Sun J, Choi V, Van Dyke T, Samulski RJ, Rathmell WK
Angiogenesis. 2010
PubMed ID: 20221685
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A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.
Alimonti A, Nardella C, Chen Z, Clohessy JG, Carracedo A, Trotman LC, Cheng K, Varmeh S, Kozma SC, Thomas G, Rosivatz E, Woscholski R, Cognetti F, Scher HI, Pandolfi PP
J Clin Invest. 2010
PubMed ID: 20197621
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Signaling via Alk5 controls the ontogeny of lung Clara cells.
Xing Y, Li C, Li A, Sridurongrit S, Tiozzo C, Bellusci S, Borok Z, Kaartinen V, Minoo P
Development. 2010
PubMed ID: 20147383
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Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling.
Hu M, Sun XJ, Zhang YL, Kuang Y, Hu CQ, Wu WL, Shen SH, Du TT, Li H, He F, Xiao HS, Wang ZG, Liu TX, Lu H, Huang QH, Chen SJ, Chen Z
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133625
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Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer.
Reid AH, Attard G, Ambroisine L, Fisher G, Kovacs G, Brewer D, Clark J, Flohr P, Edwards S, Berney DM, Foster CS, Fletcher A, Gerald WL, Møller H, Reuter VE, Scardino PT, Cuzick J, de Bono JS, Cooper CS, Transatlantic Prostate Group
Br J Cancer. 2010
PubMed ID: 20104229
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Oncolysis of prostate cancers induced by vesicular stomatitis virus in PTEN knockout mice.
Moussavi M, Fazli L, Tearle H, Guo Y, Cox M, Bell J, Ong C, Jia W, Rennie PS
Cancer Res. 2010
PubMed ID: 20145134
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Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells.
Omerovic J, Clague MJ, Prior IA
Biochem J. 2010
PubMed ID: 19922411
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TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pathway.
Kim EJ, Lee SY, Kim TR, Choi SI, Cho EW, Kim KC, Kim IG
Biochem Biophys Res Commun. 2010
PubMed ID: 20079711
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Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.
Medyouf H, Gao X, Armstrong F, Gusscott S, Liu Q, Gedman AL, Matherly LH, Schultz KR, Pflumio F, You MJ, Weng AP
Blood. 2010
PubMed ID: 20008304
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Autophagy impairment inhibits differentiation of glioma stem/progenitor cells.
Zhao Y, Huang Q, Yang J, Lou M, Wang A, Dong J, Qin Z, Zhang T
Brain Res. 2010
PubMed ID: 20004652
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FSH-stimulated PTEN activity accounts for the lack of FSH mitogenic effect in prepubertal rat Sertoli cells.
Dupont J, Musnier A, Decourtye J, Boulo T, Lécureuil C, Guillou H, Valet S, Fouchécourt S, Pitetti JL, Nef S, Reiter E, Crépieux P
Mol Cell Endocrinol. 2010
PubMed ID: 19778579
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Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.
Davidson L, Maccario H, Perera NM, Yang X, Spinelli L, Tibarewal P, Glancy B, Gray A, Weijer CJ, Downes CP, Leslie NR
Oncogene. 2010
PubMed ID: 19915616
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Infrequent hypermethylation of the PTEN gene in Korean non-small-cell lung cancers.
Kim DS, Lee SM, Yoon GS, Choi JE, Park JY
Cancer Sci. 2010
PubMed ID: 20175786
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TP53 mutations in endometrial cancers: relation to PTEN gene defects.
Janiec-Jankowska A, Konopka B, Goluda C, Najmoła U
Int J Gynecol Cancer. 2010
PubMed ID: 20169661
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Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation.
Fu M, Sato Y, Lyons-Warren A, Zhang B, Kane MA, Napoli JL, Heuckeroth RO
Development. 2010
PubMed ID: 20110328
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SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation.
Thomsen MK, Ambroisine L, Wynn S, Cheah KS, Foster CS, Fisher G, Berney DM, Møller H, Reuter VE, Scardino P, Cuzick J, Ragavan N, Singh PB, Martin FL, Butler CM, Cooper CS, Swain A, Transatlantic Prostate Group
Cancer Res. 2010
PubMed ID: 20103652
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Caffeine confers radiosensitization of PTEN-deficient malignant glioma cells by enhancing ionizing radiation-induced G1 arrest and negatively regulating Akt phosphorylation.
Sinn B, Tallen G, Schroeder G, Grassl B, Schulze J, Budach V, Tinhofer I
Mol Cancer Ther. 2010
PubMed ID: 20103602
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Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation.
Michaud J, Im DS, Hla T
J Immunol. 2010
PubMed ID: 20042570
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TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic cancer cells.
Chow JY, Ban M, Wu HL, Nguyen F, Huang M, Chung H, Dong H, Carethers JM
Am J Physiol Gastrointest Liver Physiol. 2010
PubMed ID: 19940030
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Beyond BRCA1 and BRCA2 wild-type breast and/or ovarian cancer families: germline mutations in TP53 and PTEN.
Blanco A, Graña B, Fachal L, Santamariña M, Cameselle-Teijeiro J, Ruíz-Ponte C, Carracedo A, Vega A
Clin Genet. 2010
PubMed ID: 19930417
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Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles.
Adhikari D, Zheng W, Shen Y, Gorre N, Hämäläinen T, Cooney AJ, Huhtaniemi I, Lan ZJ, Liu K
Hum Mol Genet. 2010
PubMed ID: 19843540
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Methylation of PTEN as a prognostic factor in malignant melanoma of the skin.
Lahtz C, Stranzenbach R, Fiedler E, Helmbold P, Dammann RH
J Invest Dermatol. 2010
PubMed ID: 19798057
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PTEN-mediated G1 cell-cycle arrest in LNCaP prostate cancer cells is associated with altered expression of cell-cycle regulators.
van Duijn PW, Ziel-van der Made AC, van der Korput JA, Trapman J
Prostate. 2010
PubMed ID: 19784964
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UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes.
Ming M, Han W, Maddox J, Soltani K, Shea CR, Freeman DM, He YY
Oncogene. 2010
PubMed ID: 19881543
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PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice.
Peng C, Chen Y, Yang Z, Zhang H, Osterby L, Rosmarin AG, Li S
Blood. 2010
PubMed ID: 19965668
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Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes.
Jacques TS, Swales A, Brzozowski MJ, Henriquez NV, Linehan JM, Mirzadeh Z, O' Malley C, Naumann H, Alvarez-Buylla A, Brandner S
EMBO J. 2010
PubMed ID: 19927122
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PTEN status in advanced colorectal cancer treated with cetuximab.
Negri FV, Bozzetti C, Lagrasta CA, Crafa P, Bonasoni MP, Camisa R, Pedrazzi G, Ardizzoni A
Br J Cancer. 2010
PubMed ID: 19953097
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Clinical significance of genetic variations in the PI3K/PTEN/AKT/mTOR pathway in Korean patients with colorectal cancer.
Kim JG, Chae YS, Sohn SK, Kang BW, Moon JH, Lee SJ, Jeon SW, Park JS, Park JY, Choi GS
Oncology. 2010
PubMed ID: 21412012
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EGFR, PIK3CA and PTEN gene status and their protein product expression in neuroblastic tumours.
Izycka-Swieszewska E, Brzeskwiniewicz M, Wozniak A, Drozynska E, Grajkowska W, Perek D, Balcerska A, Klepacka T, Limon J
Folia Neuropathol. 2010
PubMed ID: 21225506
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The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression.
Langlois MJ, Bergeron S, Bernatchez G, Boudreau F, Saucier C, Perreault N, Carrier JC, Rivard N
PLoS One. 2010
PubMed ID: 21203412
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DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset.
Berg M, Danielsen SA, Ahlquist T, Merok MA, Ågesen TH, Vatn MH, Mala T, Sjo OH, Bakka A, Moberg I, Fetveit T, Mathisen Ø, Husby A, Sandvik O, Nesbakken A, Thiis-Evensen E, Lothe RA
PLoS One. 2010
PubMed ID: 21103049
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Posttranscriptional regulation of PTEN dosage by noncoding RNAs.
He L
Sci Signal. 2010
PubMed ID: 21045203
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Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer.
Covey TM, Edes K, Coombs GS, Virshup DM, Fitzpatrick FA
PLoS One. 2010
PubMed ID: 20975834
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Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations.
Banneau G, Guedj M, MacGrogan G, de Mascarel I, Velasco V, Schiappa R, Bonadona V, David A, Dugast C, Gilbert-Dussardier B, Ingster O, Vabres P, Caux F, de Reynies A, Iggo R, Sevenet N, Bonnet F, Longy M
Breast Cancer Res. 2010
PubMed ID: 20712882
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A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exercise.
Hamilton DL, Philp A, MacKenzie MG, Baar K
PLoS One. 2010
PubMed ID: 20661274
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Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC
PLoS One. 2010
PubMed ID: 20634891
-
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer)
PLoS Genet. 2010
PubMed ID: 20628624
-
Cancer and Lhermitte-Duclos disease are common in Cowden syndrome patients.
Riegert-Johnson DL, Gleeson FC, Roberts M, Tholen K, Youngborg L, Bullock M, Boardman LA
Hered Cancer Clin Pract. 2010
PubMed ID: 20565722
-
Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx.
Sullu Y, Gun S, Atmaca S, Karagoz F, Kandemir B
Diagn Pathol. 2010
PubMed ID: 20546613
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miR-22 forms a regulatory loop in PTEN/AKT pathway and modulates signaling kinetics.
Bar N, Dikstein R
PLoS One. 2010
PubMed ID: 20523723
-
Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma.
Castellino RC, Barwick BG, Schniederjan M, Buss MC, Becher O, Hambardzumyan D, Macdonald TJ, Brat DJ, Durden DL
PLoS One. 2010
PubMed ID: 20520772
-
Accelerated wound healing by mTOR activation in genetically defined mouse models.
Squarize CH, Castilho RM, Bugge TH, Gutkind JS
PLoS One. 2010
PubMed ID: 20498714
-
Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cell.
Zhao Z, Wu Q, Cheng J, Qiu X, Zhang J, Fan H
J Biomed Biotechnol. 2010
PubMed ID: 20467490
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[Our experience with analysis of the PTEN gene in patients suspected of having Cowden syndrome]
Vasovcák P, Foretová L, Puchmajerová A, Senkeríková M, Martínek J, Krepelová A
Klin Onkol. 2010
PubMed ID: 20465090
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Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway.
Dasari VR, Kaur K, Velpula KK, Gujrati M, Fassett D, Klopfenstein JD, Dinh DH, Rao JS
PLoS One. 2010
PubMed ID: 20436671
-
Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells.
Xu J, Zhou JY, Wei WZ, Wu GS
PLoS One. 2010
PubMed ID: 20419107
-
Clinical significance of PTEN and p-Akt co-expression in HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies.
Fabi A, Metro G, Di Benedetto A, Nisticò C, Vici P, Melucci E, Antoniani B, Perracchio L, Sperduti I, Milella M, Cognetti F, Mottolese M
Oncology. 2010
PubMed ID: 20389136
-
Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.
Poliseno L, Salmena L, Riccardi L, Fornari A, Song MS, Hobbs RM, Sportoletti P, Varmeh S, Egia A, Fedele G, Rameh L, Loda M, Pandolfi PP
Sci Signal. 2010
PubMed ID: 20388916
-
The role of the PTEN gene in malignant gliomas.
Alexiou GA, Voulgaris S
Neurol Neurochir Pol. 2010
PubMed ID: 20358487
-
DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response.
Dejeux E, Rønneberg JA, Solvang H, Bukholm I, Geisler S, Aas T, Gut IG, Børresen-Dale AL, Lønning PE, Kristensen VN, Tost J
Mol Cancer. 2010
PubMed ID: 20338046
-
Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers.
Song CH, Park SY, Eom KY, Kim JH, Kim SW, Kim JS, Kim IA
Breast Cancer Res. 2010
PubMed ID: 20226014
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[Expression of PTEN, matrix metaloproteinases 2 and 9 in thymomas].
Huang ZS, Shi F, Fu DH, Su YH, Lu WL
Zhonghua Zhong Liu Za Zhi. 2010
PubMed ID: 20211065
-
[Expression of Gemcitabine-resistance-related gene and polymorphism of ribonucleotide reductase M1 gene promoter in Gemcitabine-resistant A549/Gem and NCI-H460/Gem cell lines].
Liu XQ, Wang WX, Lin L, Song ST
Zhonghua Zhong Liu Za Zhi. 2010
PubMed ID: 20211060
-
MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol.
Ren Y, Zhou X, Mei M, Yuan XB, Han L, Wang GX, Jia ZF, Xu P, Pu PY, Kang CS
BMC Cancer. 2010
PubMed ID: 20113523
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Clinicopathological significance of nuclear PTEN expression in colorectal adenocarcinoma.
Jang KS, Song YS, Jang SH, Min KW, Na W, Jang SM, Jun YJ, Lee KH, Choi D, Paik SS
Histopathology. 2010
PubMed ID: 20102402
-
Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer.
Muggerud AA, Rønneberg JA, Wärnberg F, Botling J, Busato F, Jovanovic J, Solvang H, Bukholm I, Børresen-Dale AL, Kristensen VN, Sørlie T, Tost J
Breast Cancer Res. 2010
PubMed ID: 20056007
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Characterization of melanoma cells capable of propagating tumors from a single cell.
Held MA, Curley DP, Dankort D, McMahon M, Muthusamy V, Bosenberg MW
Cancer Res. 2010
PubMed ID: 20048081
-
Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer.
Leav I, Plescia J, Goel HL, Li J, Jiang Z, Cohen RJ, Languino LR, Altieri DC
Am J Pathol. 2010
PubMed ID: 19948822
-
AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma.
Cohen Y, Shalmon B, Korach J, Barshack I, Fridman E, Rechavi G
Gynecol Oncol. 2010
PubMed ID: 19853286
-
Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia.
Jotta PY, Ganazza MA, Silva A, Viana MB, da Silva MJ, Zambaldi LJ, Barata JT, Brandalise SR, Yunes JA
Leukemia. 2010
PubMed ID: 19829307
-
Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy.
Rane MJ, Song Y, Jin S, Barati MT, Wu R, Kausar H, Tan Y, Wang Y, Zhou G, Klein JB, Li X, Cai L
Am J Physiol Renal Physiol. 2010
PubMed ID: 19726550
-
The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.
Krentz AD, Murphy MW, Kim S, Cook MS, Capel B, Zhu R, Matin A, Sarver AL, Parker KL, Griswold MD, Looijenga LH, Bardwell VJ, Zarkower D
Proc Natl Acad Sci U S A. 2009
PubMed ID: 20007774
-
PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers.
Jin G, Kim MJ, Jeon HS, Choi JE, Kim DS, Lee EB, Cha SI, Yoon GS, Kim CH, Jung TH, Park JY
Lung Cancer. 2009
PubMed ID: 20018398
-
ERK activation is involved in tooth development via FGF10 signaling.
Cho KW, Cai J, Kim HY, Hosoya A, Ohshima H, Choi KY, Jung HS
J Exp Zool B Mol Dev Evol. 2009
PubMed ID: 19551815
-
Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer.
Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet JB, Lecomte T, Rougier P, Lievre A, Landi B, Boige V, Ducreux M, Ychou M, Bibeau F, Bouché O, Reid J, Stone S, Penault-Llorca F
J Clin Oncol. 2009
PubMed ID: 19884556
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miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation.
Garofalo M, Di Leva G, Romano G, Nuovo G, Suh SS, Ngankeu A, Taccioli C, Pichiorri F, Alder H, Secchiero P, Gasparini P, Gonelli A, Costinean S, Acunzo M, Condorelli G, Croce CM
Cancer Cell. 2009
PubMed ID: 19962668
-
Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.
Baker DJ, Jin F, Jeganathan KB, van Deursen JM
Cancer Cell. 2009
PubMed ID: 19962666
-
Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN.
Kim YC, Kitaura H, Taira T, Iguchi-Ariga SM, Ariga H
Int J Oncol. 2009
PubMed ID: 19885556
-
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells.
Song LB, Li J, Liao WT, Feng Y, Yu CP, Hu LJ, Kong QL, Xu LH, Zhang X, Liu WL, Li MZ, Zhang L, Kang TB, Fu LW, Huang WL, Xia YF, Tsao SW, Li M, Band V, Band H, Shi QH, Zeng YX, Zeng MS
J Clin Invest. 2009
PubMed ID: 19884659
-
Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction.
Puig I, Champeval D, De Santa Barbara P, Jaubert F, Lyonnet S, Larue L
J Clin Invest. 2009
PubMed ID: 19884655
-
Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells.
Malchinkhuu E, Sato K, Maehama T, Ishiuchi S, Yoshimoto Y, Mogi C, Kimura T, Kurose H, Tomura H, Okajima F
Mol Biol Cell. 2009
PubMed ID: 19864456
-
Premature ovarian failure, menopause and ovarian cancer, three nodes on the same string: Pten and other potential genes on the go.
Kuang H, Zhang L, Peng J, Chen Q
Med Hypotheses. 2009
PubMed ID: 19733443
-
Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathways.
Huang SK, White ES, Wettlaufer SH, Grifka H, Hogaboam CM, Thannickal VJ, Horowitz JC, Peters-Golden M
FASEB J. 2009
PubMed ID: 19671668
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Involvement of the PTEN-AKT-FOXO3a pathway in neuronal apoptosis in developing rat brain after hypoxia-ischemia.
Li D, Qu Y, Mao M, Zhang X, Li J, Ferriero D, Mu D
J Cereb Blood Flow Metab. 2009
PubMed ID: 19623194
-
Upregulation of PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively inhibits lipopolysaccharide-induced VCAM-1 but not ICAM-1 expression in human endothelial cells.
Tsoyi K, Kim WS, Kim YM, Kim HJ, Seo HG, Lee JH, Yun-Choi HS, Chang KC
Atherosclerosis. 2009
PubMed ID: 19540498
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RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China.
Lin Q, Geng J, Ma K, Yu J, Sun J, Shen Z, Bao G, Chen Y, Zhang H, He Y, Luo X, Feng X, Zhu J
J Cancer Res Clin Oncol. 2009
PubMed ID: 19506903
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Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy.
Browne CD, Del Nagro CJ, Cato MH, Dengler HS, Rickert RC
Immunity. 2009
PubMed ID: 19896393
-
Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression.
Sagana RL, Yan M, Cornett AM, Tsui JL, Stephenson DA, Huang SK, Moore BB, Ballinger MN, Melonakos J, Kontos CD, Aronoff DM, Peters-Golden M, White ES
J Biol Chem. 2009
PubMed ID: 19808686
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PTEN dosage is essential for neurofibroma development and malignant transformation.
Gregorian C, Nakashima J, Dry SM, Nghiemphu PL, Smith KB, Ao Y, Dang J, Lawson G, Mellinghoff IK, Mischel PS, Phelps M, Parada LF, Liu X, Sofroniew MV, Eilber FC, Wu H
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19846776
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Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model.
Mulholland DJ, Xin L, Morim A, Lawson D, Witte O, Wu H
Cancer Res. 2009
PubMed ID: 19887604
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Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1.
Zhou J, Brugarolas J, Parada LF
Hum Mol Genet. 2009
PubMed ID: 19692352
-
[Change from inflammation to carcinoma in ulcerative colitis: the role of PTEN/PI3K/AKT].
Fu DG, Huang XL, Gan HT, Zhang DK, Zhao LQ
Sichuan Da Xue Xue Bao Yi Xue Ban. 2009
PubMed ID: 20067111
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PTEN loss induces epithelial--mesenchymal transition in human colon cancer cells.
Bowen KA, Doan HQ, Zhou BP, Wang Q, Zhou Y, Rychahou PG, Evers BM
Anticancer Res. 2009
PubMed ID: 20032390
-
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
-
Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells.
Vitolo MI, Weiss MB, Szmacinski M, Tahir K, Waldman T, Park BH, Martin SS, Weber DJ, Bachman KE
Cancer Res. 2009
PubMed ID: 19843859
-
In pursuit of leucine-rich repeat-containing G protein-coupled receptor-5 regulation and function in the uterus.
Sun X, Jackson L, Dey SK, Daikoku T
Endocrinology. 2009
PubMed ID: 19797400
-
Paired box gene 8-peroxisome proliferator-activated receptor-gamma fusion protein and loss of phosphatase and tensin homolog synergistically cause thyroid hyperplasia in transgenic mice.
Diallo-Krou E, Yu J, Colby LA, Inoki K, Wilkinson JE, Thomas DG, Giordano TJ, Koenig RJ
Endocrinology. 2009
PubMed ID: 19797117
-
Epigenetic modulation of PTEN expression during antiandrogenic therapies in human prostate cancer.
Gravina GL, Biordi L, Martella F, Flati V, Ricevuto E, Ficorella C, Tombolini V, Festuccia C
Int J Oncol. 2009
PubMed ID: 19787268
-
PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells.
Ma J, Sawai H, Ochi N, Matsuo Y, Xu D, Yasuda A, Takahashi H, Wakasugi T, Takeyama H
Mol Cell Biochem. 2009
PubMed ID: 19437103
-
Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast tumor growth.
Ghosh-Choudhury T, Mandal CC, Woodruff K, St Clair P, Fernandes G, Choudhury GG, Ghosh-Choudhury N
Breast Cancer Res Treat. 2009
PubMed ID: 18953692
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PI3 kinase signals BCR-dependent mature B cell survival.
Srinivasan L, Sasaki Y, Calado DP, Zhang B, Paik JH, DePinho RA, Kutok JL, Kearney JF, Otipoby KL, Rajewsky K
Cell. 2009
PubMed ID: 19879843
-
Analysis of PTEN complex assembly and identification of heterogeneous nuclear ribonucleoprotein C as a component of the PTEN-associated complex.
Mosessian S, Avliyakulov NK, Mulholland DJ, Boontheung P, Loo JA, Wu H
J Biol Chem. 2009
PubMed ID: 19740742
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Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes.
Finlay DK, Sinclair LV, Feijoo C, Waugh CM, Hagenbeek TJ, Spits H, Cantrell DA
J Exp Med. 2009
PubMed ID: 19808258
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Pten in stromal fibroblasts suppresses mammary epithelial tumours.
Trimboli AJ, Cantemir-Stone CZ, Li F, Wallace JA, Merchant A, Creasap N, Thompson JC, Caserta E, Wang H, Chong JL, Naidu S, Wei G, Sharma SM, Stephens JA, Fernandez SA, Gurcan MN, Weinstein MB, Barsky SH, Yee L, Rosol TJ, Stromberg PC, Robinson ML, Pepin F, Hallett M, Park M, Ostrowski MC, Leone G
Nature. 2009
PubMed ID: 19847259
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Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury.
Tiozzo C, De Langhe S, Yu M, Londhe VA, Carraro G, Li M, Li C, Xing Y, Anderson S, Borok Z, Bellusci S, Minoo P
Am J Respir Crit Care Med. 2009
PubMed ID: 19574443
-
PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase.
Gupta A, Dey CS
Mol Cell Endocrinol. 2009
PubMed ID: 19501627
-
TSC2 deficiency increases PTEN via HIF1alpha.
Mahimainathan L, Ghosh-Choudhury N, Venkatesan B, Das F, Mandal CC, Dey N, Habib SL, Kasinath BS, Abboud HE, Ghosh Choudhury G
J Biol Chem. 2009
PubMed ID: 19648120
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Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia.
Yamanaka Y, Tagawa H, Takahashi N, Watanabe A, Guo YM, Iwamoto K, Yamashita J, Saitoh H, Kameoka Y, Shimizu N, Ichinohasama R, Sawada K
Blood. 2009
PubMed ID: 19641183
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A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.
Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD
Postgrad Med J. 2009
PubMed ID: 19789190
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MyosinV controls PTEN function and neuronal cell size.
van Diepen MT, Parsons M, Downes CP, Leslie NR, Hindges R, Eickholt BJ
Nat Cell Biol. 2009
PubMed ID: 19767745
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Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma.
Park JK, Lee EJ, Esau C, Schmittgen TD
Pancreas. 2009
PubMed ID: 19730150
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PTEN expression and mutation in colorectal carcinomas.
Li XH, Zheng HC, Takahashi H, Masuda S, Yang XH, Takano Y
Oncol Rep. 2009
PubMed ID: 19724853
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Involvement of Pin1 induction in epithelial-mesenchymal transition of tamoxifen-resistant breast cancer cells.
Kim MR, Choi HK, Cho KB, Kim HS, Kang KW
Cancer Sci. 2009
PubMed ID: 19681904
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Cholesteatoma growth and proliferation: posttranscriptional regulation by microRNA-21.
Friedland DR, Eernisse R, Erbe C, Gupta N, Cioffi JA
Otol Neurotol. 2009
PubMed ID: 19672202
-
Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN.
Regina S, Valentin JB, Lachot S, Lemarié E, Rollin J, Gruel Y
Clin Chem. 2009
PubMed ID: 19661141
-
p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.
Rabinovsky R, Pochanard P, McNear C, Brachmann SM, Duke-Cohan JS, Garraway LA, Sellers WR
Mol Cell Biol. 2009
PubMed ID: 19635806
-
Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis.
Li C, Li A, Li M, Xing Y, Chen H, Hu L, Tiozzo C, Anderson S, Taketo MM, Minoo P
Dev Biol. 2009
PubMed ID: 19631635
-
Mechanistic insight into WEB-2170-induced apoptosis in human acute myelogenous leukemia cells: the crucial role of PTEN.
Cellai C, Laurenzana A, Bianchi E, Sdelci S, Manfredini R, Vannucchi AM, Caporale R, Balliu M, Mannelli F, Ferrari S, Bosi A, Miniati D, Cocco PL, Veronneau S, Stankova J, Paoletti F
Exp Hematol. 2009
PubMed ID: 19615424
-
A Cre/LoxP conditional luciferase reporter transgenic mouse for bioluminescence monitoring of tumorigenesis.
Woolfenden S, Zhu H, Charest A
Genesis. 2009
PubMed ID: 19603508
-
PTEN/AKT pathway involved in histone deacetylases inhibitor induced cell growth inhibition and apoptosis of oral squamous cell carcinoma cells.
Gan YH, Zhang S
Oral Oncol. 2009
PubMed ID: 19574087
-
Dysregulated PI3K/Akt/PTEN pathway is a marker of a short disease-free survival in node-negative breast carcinoma.
Capodanno A, Camerini A, Orlandini C, Baldini E, Resta ML, Bevilacqua G, Collecchi P
Hum Pathol. 2009
PubMed ID: 19428048
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Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model.
Karuppagounder SS, Xu H, Shi Q, Chen LH, Pedrini S, Pechman D, Baker H, Beal MF, Gandy SE, Gibson GE
Neurobiol Aging. 2009
PubMed ID: 18406011
-
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.
Kim JY, Duan X, Liu CY, Jang MH, Guo JU, Pow-anpongkul N, Kang E, Song H, Ming GL
Neuron. 2009
PubMed ID: 19778506
-
A luminal epithelial stem cell that is a cell of origin for prostate cancer.
Wang X, Kruithof-de Julio M, Economides KD, Walker D, Yu H, Halili MV, Hu YP, Price SM, Abate-Shen C, Shen MM
Nature. 2009
PubMed ID: 19741607
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Inhibition of tumor growth progression by antiandrogens and mTOR inhibitor in a Pten-deficient mouse model of prostate cancer.
Zhang W, Zhu J, Efferson CL, Ware C, Tammam J, Angagaw M, Laskey J, Bettano KA, Kasibhatla S, Reilly JF, Sur C, Majumder PK
Cancer Res. 2009
PubMed ID: 19738074
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Simultaneous loss of the DLC1 and PTEN tumor suppressors enhances breast cancer cell migration.
Heering J, Erlmann P, Olayioye MA
Exp Cell Res. 2009
PubMed ID: 19482022
-
Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a.
Fine B, Hodakoski C, Koujak S, Su T, Saal LH, Maurer M, Hopkins B, Keniry M, Sulis ML, Mense S, Hibshoosh H, Parsons R
Science. 2009
PubMed ID: 19729658
-
Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis.
Hou SC, Chan LW, Chou YC, Su CY, Chen X, Shih YL, Tsai PC, Shen CK, Yan YT
FEBS Lett. 2009
PubMed ID: 19619540
-
[Expression of beta-catenin, Glut-1, PTEN proteins in uterine endometrioid adenocarcinoma and its precursor lesions].
Xiong Y, Xiong YY, Zhou YF
Zhonghua Bing Li Xue Za Zhi. 2009
PubMed ID: 20079187
-
[Effect of signal transduction inhibitors on human endometrial carcinoma cells with differential PTEN gene expression].
Xiao L, Yang YB, Shen HM, Xu CF, Wang XY, Li XM
Zhonghua Fu Chan Ke Za Zhi. 2009
PubMed ID: 20079181
-
PTEN expression is down-regulated in liver tissues of rats with hepatic fibrosis induced by biliary stenosis.
Hao LS, Zhang XL, An JY, Karlin J, Tian XP, Dun ZN, Xie SR, Chen S
APMIS. 2009
PubMed ID: 19703128
-
Utility of PTEN expression of endometrial "surface epithelial changes" and underlying atypical endometrial hyperplasia.
Quddus MR, Ologun BA, Sung CJ, Steinhoff MM, Lawrence WD
Int J Gynecol Pathol. 2009
PubMed ID: 19696618
-
Inside life of melanoma cell signaling, molecular insights, and therapeutic targets.
Sosman JA, Margolin KA
Curr Oncol Rep. 2009
PubMed ID: 19679016
-
Allelic loss of the PTEN gene and mutation of the TP53 gene in choriocarcinoma arising from gastric adenocarcinoma: analysis of loss of heterozygosity in two male patients with extragonadal choriocarcinoma.
Tate G, Suzuki T, Nemoto H, Kishimoto K, Hibi K, Mitsuya T
Cancer Genet Cytogenet. 2009
PubMed ID: 19665071
-
The protective effect of early hypothermia on PTEN phosphorylation correlates with free radical inhibition in rat stroke.
Lee SM, Zhao H, Maier CM, Steinberg GK
J Cereb Blood Flow Metab. 2009
PubMed ID: 19553907
-
Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations.
Tougeron D, Fauquembergue E, Rouquette A, Le Pessot F, Sesboüé R, Laurent M, Berthet P, Mauillon J, Di Fiore F, Sabourin JC, Michel P, Tosi M, Frébourg T, Latouche JB
Mod Pathol. 2009
PubMed ID: 19503063
-
Metaplastic breast carcinomas are basal-like breast cancers: a genomic profiling analysis.
Weigelt B, Kreike B, Reis-Filho JS
Breast Cancer Res Treat. 2009
PubMed ID: 18815879
-
Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells.
Fan HY, Liu Z, Paquet M, Wang J, Lydon JP, DeMayo FJ, Richards JS
Cancer Res. 2009
PubMed ID: 19679546
-
Systems biology reveals new strategies for personalizing cancer medicine and confirms the role of PTEN in resistance to trastuzumab.
Faratian D, Goltsov A, Lebedeva G, Sorokin A, Moodie S, Mullen P, Kay C, Um IH, Langdon S, Goryanin I, Harrison DJ
Cancer Res. 2009
PubMed ID: 19638581
-
No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer.
Phillips LS, Thompson CL, Merkulova A, Plummer SJ, Tucker TC, Casey G, Li L
World J Gastroenterol. 2009
PubMed ID: 19673018
-
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
-
Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis.
Turner JD, Langley RS, Johnston KL, Gentil K, Ford L, Wu B, Graham M, Sharpley F, Slatko B, Pearlman E, Taylor MJ
J Biol Chem. 2009
PubMed ID: 19458089
-
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
-
Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.
Fernandez-Marcos PJ, Abu-Baker S, Joshi J, Galvez A, Castilla EA, Cañamero M, Collado M, Saez C, Moreno-Bueno G, Palacios J, Leitges M, Serrano M, Moscat J, Diaz-Meco MT
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19470463
-
Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/beta-catenin genes in human herpesvirus 8-associated primary effusion lymphoma.
Boulanger E, Marchio A, Hong SS, Pineau P
Haematologica. 2009
PubMed ID: 19608668
-
Notch-1 signaling is lost in prostate adenocarcinoma and promotes PTEN gene expression.
Whelan JT, Kellogg A, Shewchuk BM, Hewan-Lowe K, Bertrand FE
J Cell Biochem. 2009
PubMed ID: 19479935
-
Nuclear PTEN levels and G2 progression in melanoma cells.
Jacob AI, Romigh T, Waite KA, Eng C
Melanoma Res. 2009
PubMed ID: 19478684
-
Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function.
Lobo GP, Waite KA, Planchon SM, Romigh T, Nassif NT, Eng C
Hum Mol Genet. 2009
PubMed ID: 19457929
-
Fluorescence in situ hybridization study shows association of PTEN deletion with ERG rearrangement during prostate cancer progression.
Han B, Mehra R, Lonigro RJ, Wang L, Suleman K, Menon A, Palanisamy N, Tomlins SA, Chinnaiyan AM, Shah RB
Mod Pathol. 2009
PubMed ID: 19407851
-
PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer.
Sircar K, Yoshimoto M, Monzon FA, Koumakpayi IH, Katz RL, Khanna A, Alvarez K, Chen G, Darnel AD, Aprikian AG, Saad F, Bismar TA, Squire JA
J Pathol. 2009
PubMed ID: 19402094
-
The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Larson Gedman A, Chen Q, Kugel Desmoulin S, Ge Y, LaFiura K, Haska CL, Cherian C, Devidas M, Linda SB, Taub JW, Matherly LH
Leukemia. 2009
PubMed ID: 19340001
-
Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.
Shay KP, Hagen TM
Biogerontology. 2009
PubMed ID: 18931933
-
X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization.
Van Themsche C, Leblanc V, Parent S, Asselin E
J Biol Chem. 2009
PubMed ID: 19473982
-
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
-
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.
Gutierrez A, Sanda T, Grebliunaite R, Carracedo A, Salmena L, Ahn Y, Dahlberg S, Neuberg D, Moreau LA, Winter SS, Larson R, Zhang J, Protopopov A, Chin L, Pandolfi PP, Silverman LB, Hunger SP, Sallan SE, Look AT
Blood. 2009
PubMed ID: 19458356
-
Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains.
Chalhoub N, Zhu G, Zhu X, Baker SJ
Genes Dev. 2009
PubMed ID: 19605683
-
In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.
Hoeflich KP, O'Brien C, Boyd Z, Cavet G, Guerrero S, Jung K, Januario T, Savage H, Punnoose E, Truong T, Zhou W, Berry L, Murray L, Amler L, Belvin M, Friedman LS, Lackner MR
Clin Cancer Res. 2009
PubMed ID: 19567590
-
Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair.
Gupta A, Yang Q, Pandita RK, Hunt CR, Xiang T, Misri S, Zeng S, Pagan J, Jeffery J, Puc J, Kumar R, Feng Z, Powell SN, Bhat A, Yaguchi T, Wadhwa R, Kaul SC, Parsons R, Khanna KK, Pandita TK
Cell Cycle. 2009
PubMed ID: 19502790
-
PTEN deficiency in a luminal ErbB-2 mouse model results in dramatic acceleration of mammary tumorigenesis and metastasis.
Schade B, Rao T, Dourdin N, Lesurf R, Hallett M, Cardiff RD, Muller WJ
J Biol Chem. 2009
PubMed ID: 19435886
-
[Effects of wild type PTEN gene on proliferation, apoptosis and the influence on apoptosis key factor Bcl-2 and Caspase family on K562 cells]
Cheng ZY, Liang WT, Niu ZY, Xue F, Yao L, Pan L
Sichuan Da Xue Xue Bao Yi Xue Ban. 2009
PubMed ID: 19764572
-
[The relationship between PTEN expression and PI3K/AKT signal pathway in colon carcinoma]
Qi JK, Huang XL, Meng ZM, Gan HT, Fu DG
Sichuan Da Xue Xue Bao Yi Xue Ban. 2009
PubMed ID: 19764563
-
Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancer.
Kim J, Eltoum IE, Roh M, Wang J, Abdulkadir SA
PLoS Genet. 2009
PubMed ID: 19578399
-
TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN.
Kato M, Putta S, Wang M, Yuan H, Lanting L, Nair I, Gunn A, Nakagawa Y, Shimano H, Todorov I, Rossi JJ, Natarajan R
Nat Cell Biol. 2009
PubMed ID: 19543271
-
Physiological PTEN expression in peripheral T-cell lymphoma not otherwise specified.
Gazzola A, Bertuzzi C, Agostinelli C, Righi S, Pileri SA, Piccaluga PP
Haematologica. 2009
PubMed ID: 19508975
-
PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma.
Petrella BL, Brinckerhoff CE
Cancer Biol Ther. 2009
PubMed ID: 19483472
-
Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia.
Ljungberg MC, Sunnen CN, Lugo JN, Anderson AE, D'Arcangelo G
Dis Model Mech. 2009
PubMed ID: 19470613
-
Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-alpha expression in macrophages by reducing IL-10 expression.
Baker AK, Wang R, Mackman N, Luyendyk JP
Mol Immunol. 2009
PubMed ID: 19447494
-
A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles.
Pollizzi K, Malinowska-Kolodziej I, Doughty C, Betz C, Ma J, Goto J, Kwiatkowski DJ
Hum Mol Genet. 2009
PubMed ID: 19357198
-
Investigation of MMAC/PTEN gene mutations and protein expression in low grade gliomas.
Cecener G, Tunca B, Egeli U, Bekar A, Guler G, Vatan O, Tolunay S
Cell Mol Neurobiol. 2009
PubMed ID: 19350382
-
Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice.
Narayanan NK, Nargi D, Randolph C, Narayanan BA
Int J Cancer. 2009
PubMed ID: 19326431
-
Endogenous tumor suppression mediated by PTEN involves survivin gene silencing.
Guha M, Plescia J, Leav I, Li J, Languino LR, Altieri DC
Cancer Res. 2009
PubMed ID: 19470765
-
Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling.
Korkaya H, Paulson A, Charafe-Jauffret E, Ginestier C, Brown M, Dutcher J, Clouthier SG, Wicha MS
PLoS Biol. 2009
PubMed ID: 19492080
-
Relevance of insulin-like growth factor 2 in the etiopathophysiology of diabetic nephropathy: possible roles of phosphatase and tensin homolog on chromosome 10 and secreted protein acidic and rich in cysteine as regulators of repair.
Sireesha M, Sambasivan V, Kumar VK, Radha S, Raj AY, Qurratulain H
J Diabetes. 2009
PubMed ID: 20929508
-
[Mutation and protein expression of PTEN gene in cervical adenocarcinoma and glandular intraepithelial neoplasia].
Huang M, Li WC, Gao DL, Wang YP, Gu YL
Zhonghua Bing Li Xue Za Zhi. 2009
PubMed ID: 19781347
-
[Morphological diagnosis of endometrial intraepithelial neoplasia and expression of PTEN].
Zhou WX, Liang ZY, Gao J, Liu TH
Zhonghua Bing Li Xue Za Zhi. 2009
PubMed ID: 19781346
-
The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ
PLoS Genet. 2009
PubMed ID: 19521500
-
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo.
Huse JT, Brennan C, Hambardzumyan D, Wee B, Pena J, Rouhanifard SH, Sohn-Lee C, le Sage C, Agami R, Tuschl T, Holland EC
Genes Dev. 2009
PubMed ID: 19487573
-
Pediatric juvenile polyposis syndromes: an update.
Huang SC, Erdman SH
Curr Gastroenterol Rep. 2009
PubMed ID: 19463221
-
Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation.
Sarraj B, Massberg S, Li Y, Kasorn A, Subramanian K, Loison F, Silberstein LE, von Andrian U, Luo HR
J Immunol. 2009
PubMed ID: 19454716
-
A reduction in Pten tumor suppressor activity promotes ErbB-2-induced mouse prostate adenocarcinoma formation through the activation of signaling cascades downstream of PDK1.
Rodriguez OC, Lai EW, Vissapragada S, Cromelin C, Avetian M, Salinas P, Ramos H, Kallakury B, Casimiro M, Lisanti MP, Tanowitz HB, Pacak K, Glazer RI, Avantaggiati M, Albanese C
Am J Pathol. 2009
PubMed ID: 19443706
-
PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer.
Loupakis F, Pollina L, Stasi I, Ruzzo A, Scartozzi M, Santini D, Masi G, Graziano F, Cremolini C, Rulli E, Canestrari E, Funel N, Schiavon G, Petrini I, Magnani M, Tonini G, Campani D, Floriani I, Cascinu S, Falcone A
J Clin Oncol. 2009
PubMed ID: 19398573
-
Pancreas-specific Pten deficiency causes partial resistance to diabetes and elevated hepatic AKT signaling.
Tong Z, Fan Y, Zhang W, Xu J, Cheng J, Ding M, Deng H
Cell Res. 2009
PubMed ID: 19365404
-
Insulin attenuates the insulin-like growth factor-I (IGF-I)-Akt pathway, not IGF-I-extracellularly regulated kinase pathway, in luteinized granulosa cells with an increase in PTEN.
Iwase A, Goto M, Harata T, Takigawa S, Nakahara T, Suzuki K, Manabe S, Kikkawa F
J Clin Endocrinol Metab. 2009
PubMed ID: 19318457
-
Inhibition of vascular smooth-muscle cell proliferation and arterial restenosis by HO-3867, a novel synthetic curcuminoid, through up-regulation of PTEN expression.
Selvendiran K, Kuppusamy ML, Bratasz A, Tong L, Rivera BK, Rink C, Sen CK, Kálai T, Hideg K, Kuppusamy P
J Pharmacol Exp Ther. 2009
PubMed ID: 19276401
-
DeltaNp73alpha inhibits PTEN expression in thyroid cancer cells.
Vella V, Puppin C, Damante G, Vigneri R, Sanfilippo M, Vigneri P, Tell G, Frasca F
Int J Cancer. 2009
PubMed ID: 19173293
-
Epithelial phosphatase and tensin homolog regulates intestinal architecture and secretory cell commitment and acts as a modifier gene in neoplasia.
Langlois MJ, Roy SA, Auclair BA, Jones C, Boudreau F, Carrier JC, Rivard N, Perreault N
FASEB J. 2009
PubMed ID: 19168705
-
Conditional loss of PTEN leads to skeletal abnormalities and lipoma formation.
Hsieh SC, Chen NT, Lo SH
Mol Carcinog. 2009
PubMed ID: 18973188
-
Mutational spectrum of conserved regions of TP53 and PTEN genes in Kangri cancer (of the skin) in the Kashmiri population.
Hussain I, ul Rehman S, Afroze D, Zahoor L, Abdullah S, Hafiz A, Shah ZA, Iqbal S, Shaffi M, Das BC, Siddiqi MA
Mutat Res. 2009
PubMed ID: 19486858
-
Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity.
Cao J, Schulte J, Knight A, Leslie NR, Zagozdzon A, Bronson R, Manevich Y, Beeson C, Neumann CA
EMBO J. 2009
PubMed ID: 19369943
-
Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer.
Miller TW, Pérez-Torres M, Narasanna A, Guix M, Stål O, Pérez-Tenorio G, Gonzalez-Angulo AM, Hennessy BT, Mills GB, Kennedy JP, Lindsley CW, Arteaga CL
Cancer Res. 2009
PubMed ID: 19435893
-
Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells.
Fournier MV, Fata JE, Martin KJ, Yaswen P, Bissell MJ
Cancer Res. 2009
PubMed ID: 19417140
-
Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia.
Li Y, Jia Y, Pichavant M, Loison F, Sarraj B, Kasorn A, You J, Robson BE, Umetsu DT, Mizgerd JP, Ye K, Luo HR
Blood. 2009
PubMed ID: 19286998
-
Long-term survivors of glioblastoma: clinical features and molecular analysis.
Sonoda Y, Kumabe T, Watanabe M, Nakazato Y, Inoue T, Kanamori M, Tominaga T
Acta Neurochir (Wien). 2009
PubMed ID: 19730774
-
PI3K/Akt pathway mutations in Retinoblastoma.
Cohen Y, Merhavi-Shoham E, Avraham-Lubin BC, Savetsky M, Frenkel S, Pe'er J, Goldenberg-Cohen N
Invest Ophthalmol Vis Sci. 2009
PubMed ID: 19420344
-
Significance of phosphatase and tensin homologue (PTEN), O(6)-methylguanine-DNA methyltransferase (MGMT), and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein expression in gynaecomastia.
Zhu L, Liu Z, Yang J, Cai J
J Int Med Res. 2009
PubMed ID: 19589246
-
Genetic alterations in the PI3K pathway in prostate cancer.
Sun X, Huang J, Homma T, Kita D, Klocker H, Schafer G, Boyle P, Ohgaki H
Anticancer Res. 2009
PubMed ID: 19443396
-
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.
Carver BS, Tran J, Gopalan A, Chen Z, Shaikh S, Carracedo A, Alimonti A, Nardella C, Varmeh S, Scardino PT, Cordon-Cardo C, Gerald W, Pandolfi PP
Nat Genet. 2009
PubMed ID: 19396168
-
Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis.
King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH, Taylor BS, Sander C, Cardiff RD, Couto SS, Gerald WL, Sawyers CL
Nat Genet. 2009
PubMed ID: 19396167
-
PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth.
Blando J, Portis M, Benavides F, Alexander A, Mills G, Dave B, Conti CJ, Kim J, Walker CL
Am J Pathol. 2009
PubMed ID: 19395652
-
Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.
Hay T, Matthews JR, Pietzka L, Lau A, Cranston A, Nygren AO, Douglas-Jones A, Smith GC, Martin NM, O'Connor M, Clarke AR
Cancer Res. 2009
PubMed ID: 19383921
-
Crosstalk between PTEN/Akt2 and TGFbeta signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model.
Taniai E, Kawai M, Dewa Y, Nishimura J, Harada T, Saegusa Y, Matsumoto S, Takahashi M, Mitsumori K, Shibutani M
Cancer Sci. 2009
PubMed ID: 19309364
-
Braf(V600E) cooperates with Pten loss to induce metastatic melanoma.
Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky WE, You MJ, DePinho RA, McMahon M, Bosenberg M
Nat Genet. 2009
PubMed ID: 19282848
-
Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis.
Boyer A, Paquet M, Laguë MN, Hermo L, Boerboom D
Carcinogenesis. 2009
PubMed ID: 19237610
-
IGF1-induced AKT phosphorylation and cell proliferation are suppressed with the increase in PTEN during luteinization in human granulosa cells.
Goto M, Iwase A, Harata T, Takigawa S, Suzuki K, Manabe S, Kikkawa F
Reproduction. 2009
PubMed ID: 19225041
-
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
-
PTEN deficiency is a common defect in juvenile myelomonocytic leukemia.
Liu YL, Castleberry RP, Emanuel PD
Leuk Res. 2009
PubMed ID: 19010541
-
Expression profiling of supraglottic carcinoma: PTEN and thrombospondin 2 are associated with inhibition of lymphatic metastasis.
Bai W, Wang L, Ji W, Gao H
Acta Otolaryngol. 2009
PubMed ID: 18720079
-
Induction of gene encoding FABP4 in Pten-null keratinocytes.
Tsuda M, Inoue-Narita T, Suzuki A, Itami S, Blumenberg M, Manabe M
FEBS Lett. 2009
PubMed ID: 19303874
-
Genetic mutations associated with cigarette smoking in pancreatic cancer.
Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH
Cancer Res. 2009
PubMed ID: 19351817
-
Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo.
Miller KA, Yeager N, Baker K, Liao XH, Refetoff S, Di Cristofano A
Cancer Res. 2009
PubMed ID: 19351816
-
Post-transcriptional and post-translational regulation of PTEN by transforming growth factor-beta1.
Yang Y, Zhou F, Fang Z, Wang L, Li Z, Sun L, Wang C, Yao W, Cai X, Jin J, Zha X
J Cell Biochem. 2009
PubMed ID: 19206163
-
Rak functions as a tumor suppressor by regulating PTEN protein stability and function.
Yim EK, Peng G, Dai H, Hu R, Li K, Lu Y, Mills GB, Meric-Bernstam F, Hennessy BT, Craven RJ, Lin SY
Cancer Cell. 2009
PubMed ID: 19345329
-
Pharmacogenomic Profiling of the PI3K/PTEN Pathway in Sporadic Breast Cancer.
Nassiri I, Faghihi M, Tavassoli M
Iran Biomed J. 2009
PubMed ID: 19471547
-
Expression status and mutational analysis of the PTEN and P13K subunit genes in ovarian granulosa cell tumors.
Bittinger S, Alexiadis M, Fuller PJ
Int J Gynecol Cancer. 2009
PubMed ID: 19407556
-
Upregulation of PTEN involved in scorpion venom-induced apoptosis in a lymphoma cell line.
Gao F, Li H, Chen YD, Yu XN, Wang R, Chen XL
Leuk Lymphoma. 2009
PubMed ID: 19373662
-
Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer.
Attard G, Swennenhuis JF, Olmos D, Reid AH, Vickers E, A'Hern R, Levink R, Coumans F, Moreira J, Riisnaes R, Oommen NB, Hawche G, Jameson C, Thompson E, Sipkema R, Carden CP, Parker C, Dearnaley D, Kaye SB, Cooper CS, Molina A, Cox ME, Terstappen LW, de Bono JS
Cancer Res. 2009
PubMed ID: 19339269
-
Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma.
Hino R, Uozaki H, Murakami N, Ushiku T, Shinozaki A, Ishikawa S, Morikawa T, Nakaya T, Sakatani T, Takada K, Fukayama M
Cancer Res. 2009
PubMed ID: 19339266
-
Determination of genetic predisposition to patent ductus arteriosus in preterm infants.
Dagle JM, Lepp NT, Cooper ME, Schaa KL, Kelsey KJ, Orr KL, Caprau D, Zimmerman CR, Steffen KM, Johnson KJ, Marazita ML, Murray JC
Pediatrics. 2009
PubMed ID: 19336370
-
Combined PTEN and p27kip1 protein expression patterns are associated with obesity and prognosis in endometrial carcinomas.
Dellas A, Jundt G, Sartorius G, Schneider M, Moch H
Clin Cancer Res. 2009
PubMed ID: 19293259
-
Bcl2 -938C/A polymorphism carries increased risk of biochemical recurrence after radical prostatectomy.
Hirata H, Hinoda Y, Kikuno N, Suehiro Y, Shahryari V, Ahmad AE, Tabatabai ZL, Igawa M, Dahiya R
J Urol. 2009
PubMed ID: 19237173
-
Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis.
Catasus L, Gallardo A, Cuatrecasas M, Prat J
Mod Pathol. 2009
PubMed ID: 19234438
-
MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue.
Roy S, Khanna S, Hussain SR, Biswas S, Azad A, Rink C, Gnyawali S, Shilo S, Nuovo GJ, Sen CK
Cardiovasc Res. 2009
PubMed ID: 19147652
-
Differential expression of PTEN in normal adult rat brain and upregulation of PTEN and p-Akt in the ischemic cerebral cortex.
Cai QY, Chen XS, Zhong SC, Luo X, Yao ZX
Anat Rec (Hoboken). 2009
PubMed ID: 19142997
-
Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes.
Vinciguerra M, Sgroi A, Veyrat-Durebex C, Rubbia-Brandt L, Buhler LH, Foti M
Hepatology. 2009
PubMed ID: 19072831
-
RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs.
Lorente A, Mueller W, Urdangarín E, Lázcoz P, Lass U, von Deimling A, Castresana JS
Brain Pathol. 2009
PubMed ID: 18616639
-
FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation.
Mei Y, Zhang Y, Yamamoto K, Xie W, Mak TW, You H
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19276113
-
Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation.
Salvesen HB, Carter SL, Mannelqvist M, Dutt A, Getz G, Stefansson IM, Raeder MB, Sos ML, Engelsen IB, Trovik J, Wik E, Greulich H, Bø TH, Jonassen I, Thomas RK, Zander T, Garraway LA, Oyan AM, Sellers WR, Kalland KH, Meyerson M, Akslen LA, Beroukhim R
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19261849
-
Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity.
Rong Y, Belozerov VE, Tucker-Burden C, Chen G, Durden DL, Olson JJ, Van Meir EG, Mackman N, Brat DJ
Cancer Res. 2009
PubMed ID: 19276385
-
Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas.
Han S, Polizzano C, Nielsen GP, Hornicek FJ, Rosenberg AE, Ramesh V
Clin Cancer Res. 2009
PubMed ID: 19276265
-
Inactivation of p53 and Pten promotes invasive bladder cancer.
Puzio-Kuter AM, Castillo-Martin M, Kinkade CW, Wang X, Shen TH, Matos T, Shen MM, Cordon-Cardo C, Abate-Shen C
Genes Dev. 2009
PubMed ID: 19261747
-
PTEN and p53 are required for hypoxia induced expression of maspin in glioblastoma cells.
Eitel JA, Bijangi-Vishehsaraei K, Saadatzadeh MR, Bhavsar JR, Murphy MP, Pollok KE, Mayo LD
Cell Cycle. 2009
PubMed ID: 19221500
-
Oviduct-specific glycoprotein is a molecular marker for invasion in endometrial tumorigenesis identified using a relevant mouse model.
Wang H, Joshi A, Iaconis L, Solomon GJ, Xiang Z, Verhage HG, Douglas W, Ronnett BM, Ellenson LH
Int J Cancer. 2009
PubMed ID: 19101990
-
Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1.
Fuchs S, Herzog D, Sumara G, Büchmann-Møller S, Civenni G, Wu X, Chrostek-Grashoff A, Suter U, Ricci R, Relvas JB, Brakebusch C, Sommer L
Cell Stem Cell. 2009
PubMed ID: 19265663
-
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells.
Bleau AM, Hambardzumyan D, Ozawa T, Fomchenko EI, Huse JT, Brennan CW, Holland EC
Cell Stem Cell. 2009
PubMed ID: 19265662
-
[The expression of PTEN and P16 protein in nasal inverted papilloma].
Zhao J, Wang Y, Kong W
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009
PubMed ID: 19522184
-
Expression of FAK and PTEN in bronchioloalveolar carcinoma and lung adenocarcinoma.
Wang C, Yang R, Yue D, Zhang Z
Lung. 2009
PubMed ID: 19242756
-
Conserved gene expression programs integrate mammalian prostate development and tumorigenesis.
Pritchard C, Mecham B, Dumpit R, Coleman I, Bhattacharjee M, Chen Q, Sikes RA, Nelson PS
Cancer Res. 2009
PubMed ID: 19223557
-
PTEN expression controls cellular response to cetuximab by mediating PI3K/AKT and RAS/RAF/MAPK downstream signaling in KRAS wild-type, hormone refractory prostate cancer cells.
Bouali S, Chrétien AS, Ramacci C, Rouyer M, Becuwe P, Merlin JL
Oncol Rep. 2009
PubMed ID: 19212633
-
Clinical significance of miR-21 expression in breast cancer: SYBR-Green I-based real-time RT-PCR study of invasive ductal carcinoma.
Huang GL, Zhang XH, Guo GL, Huang KT, Yang KY, Shen X, You J, Hu XQ
Oncol Rep. 2009
PubMed ID: 19212625
-
Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice.
Ishii H, Horie Y, Ohshima S, Anezaki Y, Kinoshita N, Dohmen T, Kataoka E, Sato W, Goto T, Sasaki J, Sasaki T, Watanabe S, Suzuki A, Ohnishi H
J Hepatol. 2009
PubMed ID: 19162361
-
Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications.
Sakamoto K, Iwasaki K, Sugiyama H, Tsuji Y
Mol Biol Cell. 2009
PubMed ID: 19158375
-
Conditional Pten knock-out mice: a model for metastatic phaeochromocytoma.
Korpershoek E, Loonen AJ, Corvers S, van Nederveen FH, Jonkers J, Ma X, Ziel-van der Made A, Korsten H, Trapman J, Dinjens WN, de Krijger RR
J Pathol. 2009
PubMed ID: 19142977
-
Antifolate/folate-activated HGF/c-Met signalling pathways in mouse kidneys-the putative role of their downstream effectors in cross-talk with androgen receptor.
Dudkowska M, Bajer S, Jaworski T, Zielińska J, Manteuffel-Cymborowska M, Grzelakowska-Sztabert B
Arch Biochem Biophys. 2009
PubMed ID: 19135973
-
PTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15.
Peacock JW, Palmer J, Fink D, Ip S, Pietras EM, Mui AL, Chung SW, Gleave ME, Cox ME, Parsons R, Peter ME, Ong CJ
Mol Cell Biol. 2009
PubMed ID: 19103758
-
Regulation of cell cycle entry by PTEN in smooth muscle cell proliferation of human coronary artery bypass conduits.
Jia G, Mitra AK, Gangahar DM, Agrawal DK
J Cell Mol Med. 2009
PubMed ID: 18544045
-
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.
Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Pfannl R, Bronson RT, Chen JW, Weissleder R, Housman DE, Charest A
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19196966
-
Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy.
Hildebrandt MA, Yang H, Hung MC, Izzo JG, Huang M, Lin J, Ajani JA, Wu X
J Clin Oncol. 2009
PubMed ID: 19164214
-
PTEN downregulates p75NTR expression by decreasing DNA-binding activity of Sp1.
Rankin SL, Guy CS, Mearow KM
Biochem Biophys Res Commun. 2009
PubMed ID: 19114034
-
Id-1 activates Akt-mediated Wnt signaling and p27(Kip1) phosphorylation through PTEN inhibition.
Lee JY, Kang MB, Jang SH, Qian T, Kim HJ, Kim CH, Kim Y, Kong G
Oncogene. 2009
PubMed ID: 19079342
-
Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis.
Gregorian C, Nakashima J, Le Belle J, Ohab J, Kim R, Liu A, Smith KB, Groszer M, Garcia AD, Sofroniew MV, Carmichael ST, Kornblum HI, Liu X, Wu H
J Neurosci. 2009
PubMed ID: 19211894
-
Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice.
Zhou J, Blundell J, Ogawa S, Kwon CH, Zhang W, Sinton C, Powell CM, Parada LF
J Neurosci. 2009
PubMed ID: 19211884
-
Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior.
Page DT, Kuti OJ, Prestia C, Sur M
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19208814
-
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.
Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM
Cancer Cell. 2009
PubMed ID: 19185849
-
[The role of PTEN-FAK signaling pathway in metastasis and invasive ability of leukemia cells]
Cheng ZY, Guo XL, Li SH, Wang SY, Yang XY, Xue F, Wen SP, Pan L
Zhonghua Xue Ye Xue Za Zhi. 2009
PubMed ID: 19563023
-
The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly.
Varga EA, Pastore M, Prior T, Herman GE, McBride KL
Genet Med. 2009
PubMed ID: 19265751
-
Correlation between PTEN expression and PI3K/Akt signal pathway in endometrial carcinoma.
Gao Q, Ye F, Xia X, Xing H, Lu Y, Zhou J, Ma D
J Huazhong Univ Sci Technolog Med Sci. 2009
PubMed ID: 19224164
-
Interactions between PTEN and the c-Met pathway in glioblastoma and implications for therapy.
Li Y, Guessous F, DiPierro C, Zhang Y, Mudrick T, Fuller L, Johnson E, Marcinkiewicz L, Engelhardt M, Kefas B, Schiff D, Kim J, Abounader R
Mol Cancer Ther. 2009
PubMed ID: 19190120
-
Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma.
Moral M, Segrelles C, Lara MF, Martínez-Cruz AB, Lorz C, Santos M, García-Escudero R, Lu J, Kiguchi K, Buitrago A, Costa C, Saiz C, Rodriguez-Peralto JL, Martinez-Tello FJ, Rodriguez-Pinilla M, Sanchez-Cespedes M, Garín M, Grande T, Bravo A, DiGiovanni J, Paramio JM
Cancer Res. 2009
PubMed ID: 19176372
-
Laminar and compartmental regulation of dendritic growth in mature cortex.
Chow DK, Groszer M, Pribadi M, Machniki M, Carmichael ST, Liu X, Trachtenberg JT
Nat Neurosci. 2009
PubMed ID: 19151711
-
Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury.
Ruan H, Li J, Ren S, Gao J, Li G, Kim R, Wu H, Wang Y
J Mol Cell Cardiol. 2009
PubMed ID: 19038262
-
PTEN promoter methylation and LOH of 10q22-23 locus in PTEN expression of ovarian clear cell adenocarcinomas.
Ho CM, Lin MC, Huang SH, Huang CJ, Lai HC, Chien TY, Chang SF
Gynecol Oncol. 2009
PubMed ID: 19007975
-
Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast cancer cells.
Das T, Bae YH, Wells A, Roy P
J Cell Physiol. 2009
PubMed ID: 18937284
-
EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors.
Li L, Dutra A, Pak E, Labrie JE, Gerstein RM, Pandolfi PP, Recht LD, Ross AH
Neuro Oncol. 2009
PubMed ID: 18812521
-
Loss of PTEN function may account for reduced proliferation pathway sensitivity to LY294002 in human prostate and bladder cancer cells.
Kanda S, Kanetake H, Miyata Y
J Cancer Res Clin Oncol. 2009
PubMed ID: 18726116
-
PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancer.
Guigon CJ, Zhao L, Willingham MC, Cheng SY
Oncogene. 2009
PubMed ID: 18997818
-
The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma.
Chung JY, Hong SM, Choi BY, Cho H, Yu E, Hewitt SM
Clin Cancer Res. 2009
PubMed ID: 19147772
-
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.
Rahdar M, Inoue T, Meyer T, Zhang J, Vazquez F, Devreotes PN
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19114656
-
PTEN regulation by Akt-EGR1-ARF-PTEN axis.
Yu J, Zhang SS, Saito K, Williams S, Arimura Y, Ma Y, Ke Y, Baron V, Mercola D, Feng GS, Adamson E, Mustelin T
EMBO J. 2009
PubMed ID: 19057511
-
The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations.
Dubrovska A, Kim S, Salamone RJ, Walker JR, Maira SM, García-Echeverría C, Schultz PG, Reddy VA
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19116269
-
Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model.
Alcantara Llaguno S, Chen J, Kwon CH, Jackson EL, Li Y, Burns DK, Alvarez-Buylla A, Parada LF
Cancer Cell. 2009
PubMed ID: 19111880
-
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway.
Mounir Z, Krishnamoorthy JL, Robertson GP, Scheuner D, Kaufman RJ, Georgescu MM, Koromilas AE
Sci Signal. 2009
PubMed ID: 20029030
-
PTEN inhibits BMI1 function independently of its phosphatase activity.
Fan C, He L, Kapoor A, Rybak AP, De Melo J, Cutz JC, Tang D
Mol Cancer. 2009
PubMed ID: 19903340
-
P-REX2a driving tumorigenesis by PTEN inhibition.
Leslie NR
Sci Signal. 2009
PubMed ID: 19861688
-
Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons.
Diaz-Ruiz O, Zapata A, Shan L, Zhang Y, Tomac AC, Malik N, de la Cruz F, Bäckman CM
PLoS One. 2009
PubMed ID: 19750226
-
Differential p53-independent outcomes of p19(Arf) loss in oncogenesis.
Chen Z, Carracedo A, Lin HK, Koutcher JA, Behrendt N, Egia A, Alimonti A, Carver BS, Gerald W, Teruya-Feldstein J, Loda M, Pandolfi PP
Sci Signal. 2009
PubMed ID: 19690330
-
Gene expression analysis of an EGFR indirectly related pathway identified PTEN and MMP9 as reliable diagnostic markers for human glial tumor specimens.
Comincini S, Paolillo M, Barbieri G, Palumbo S, Sbalchiero E, Azzalin A, Russo MA, Schinelli S
J Biomed Biotechnol. 2009
PubMed ID: 19657395
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Oocyte-specific deletion of Pten in mice reveals a stage-specific function of PTEN/PI3K signaling in oocytes in controlling follicular activation.
Jagarlamudi K, Liu L, Adhikari D, Reddy P, Idahl A, Ottander U, Lundin E, Liu K
PLoS One. 2009
PubMed ID: 19587782
-
Accumulating progenitor cells in the luminal epithelial cell layer are candidate tumor initiating cells in a Pten knockout mouse prostate cancer model.
Korsten H, Ziel-van der Made A, Ma X, van der Kwast T, Trapman J
PLoS One. 2009
PubMed ID: 19461893
-
Mutational analysis of the PTEN gene in women with premature ovarian failure.
Shimizu Y, Kimura F, Takebayashi K, Fujiwara M, Takakura K, Takahashi K
Acta Obstet Gynecol Scand. 2009
PubMed ID: 19449221
-
Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex.
Lu J, Jeong H, Kong N, Yang Y, Carroll J, Luo HR, Silberstein LE, Yupoma, Chai L
PLoS One. 2009
PubMed ID: 19440552
-
The tumor suppressor protein PTEN inhibits rat hepatic stellate cell activation.
Takashima M, Parsons CJ, Ikejima K, Watanabe S, White ES, Rippe RA
J Gastroenterol. 2009
PubMed ID: 19436944
-
Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities.
Lam JB, Chow KH, Xu A, Lam KS, Liu J, Wong NS, Moon RT, Shepherd PR, Cooper GJ, Wang Y
PLoS One. 2009
PubMed ID: 19319191
-
Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer.
Couto SS, Cao M, Duarte PC, Banach-Petrosky W, Wang S, Romanienko P, Wu H, Cardiff RD, Abate-Shen C, Cunha GR
Differentiation. 2009
PubMed ID: 19281769
-
Expression of PTEN and SHP1, investigated from tissue microarrays in pediatric acute lymphoblastic, leukemia.
Gauffin F, Diffner E, Gustafsson B, Nordgren A, Wingren AG, Sander B, Persson JL, Gustafsson B
Pediatr Hematol Oncol. 2009
PubMed ID: 19206008
-
Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis.
Wu Z, Cho H, Hampton GM, Theodorescu D
Neoplasia. 2009
PubMed ID: 19107233
-
Irs2 inactivation suppresses tumor progression in Pten+/- mice.
Szabolcs M, Keniry M, Simpson L, Reid LJ, Koujak S, Schiff SC, Davidian G, Licata S, Gruvberger-Saal S, Murty VV, Nandula S, Efstratiadis A, Kushner JA, White MF, Parsons R
Am J Pathol. 2009
PubMed ID: 19095950
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The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies.
Bansal N, Yendluri V, Wenham RM
Cancer Control. 2009
PubMed ID: 19078924
-
Genetically engineered mouse models of brain cancer and the promise of preclinical testing.
Huse JT, Holland EC
Brain Pathol. 2009
PubMed ID: 19076778
-
Immunohistochemical expression of PTEN and phosphorylated Akt are not correlated with clinical outcome in breast cancer patients treated with trastuzumab-containing neo-adjuvant chemotherapy.
Yonemori K, Tsuta K, Shimizu C, Hatanaka Y, Hashizume K, Ono M, Kouno T, Ando M, Tamura K, Katsumata N, Hasegawa T, Kinoshita T, Fujiwara Y
Med Oncol. 2009
PubMed ID: 19016009
-
Temporal PTEN inactivation causes proliferation of saphenous vein smooth muscle cells of human CABG conduits.
Mitra AK, Jia G, Gangahar DM, Agrawal DK
J Cell Mol Med. 2009
PubMed ID: 18363844
-
A cross-talk between oncogenic Ras and tumor suppressor PTEN through FAK Tyr861 phosphorylation in NIH/3T3 mouse embryonic fibroblasts.
Bahk YY, Cho IH, Kim TS
Biochem Biophys Res Commun. 2008
PubMed ID: 19000654
-
Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis.
Rychahou PG, Kang J, Gulhati P, Doan HQ, Chen LA, Xiao SY, Chung DH, Evers BM
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19075230
-
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium.
Fu Y, Wey S, Wang M, Ye R, Liao CP, Roy-Burman P, Lee AS
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19033462
-
[Impact of PTEN gene knockout in human breast carcinoma MCF-7 cells on activity of JNK pathway]
Jin Y, Hu JL, Xiao L, Cui W
Ai Zheng. 2008
PubMed ID: 19079986
-
Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064572
-
Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.
Qiu W, Federico L, Naples M, Avramoglu RK, Meshkani R, Zhang J, Tsai J, Hussain M, Dai K, Iqbal J, Kontos CD, Horie Y, Suzuki A, Adeli K
Hepatology. 2008
PubMed ID: 19026012
-
B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta.
Henley T, Kovesdi D, Turner M
Eur J Immunol. 2008
PubMed ID: 19016531
-
Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation.
Marsh V, Winton DJ, Williams GT, Dubois N, Trumpp A, Sansom OJ, Clarke AR
Nat Genet. 2008
PubMed ID: 19011632
-
Hedgehog signaling regulates brain tumor-initiating cell proliferation and portends shorter survival for patients with PTEN-coexpressing glioblastomas.
Xu Q, Yuan X, Liu G, Black KL, Yu JS
Stem Cells. 2008
PubMed ID: 18787206
-
Reversal of the malignant phenotype of ovarian cancer A2780 cells through transfection with wild-type PTEN gene.
Wu H, Wang S, Weng D, Xing H, Song X, Zhu T, Xia X, Weng Y, Xu G, Meng L, Zhou J, Ma D
Cancer Lett. 2008
PubMed ID: 18662848
-
Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium.
Kim JW, Kang KH, Burrola P, Mak TW, Lemke G
Genes Dev. 2008
PubMed ID: 18997061
-
Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway.
Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z
Science. 2008
PubMed ID: 18988856
-
PTEN mutation: many birds with one stone in tumorigenesis.
Liu W, Zhou Y, Reske SN, Shen C
Anticancer Res. 2008
PubMed ID: 19189642
-
The role of the PI3K-AKT kinase pathway in T-cell development beyond the beta checkpoint.
Xue L, Chiang L, Kang C, Winoto A
Eur J Immunol. 2008
PubMed ID: 18991293
-
PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress.
Yang G, Sun Q, Teng Y, Li F, Weng T, Yang X
Development. 2008
PubMed ID: 18832389
-
Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/AKT signaling pathway in thyroid tumors.
Hou P, Ji M, Xing M
Cancer. 2008
PubMed ID: 18831514
-
PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability.
Silva A, Yunes JA, Cardoso BA, Martins LR, Jotta PY, Abecasis M, Nowill AE, Leslie NR, Cardoso AA, Barata JT
J Clin Invest. 2008
PubMed ID: 18830414
-
Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status.
Danielsen SA, Lind GE, Bjørnslett M, Meling GI, Rognum TO, Heim S, Lothe RA
Hum Mutat. 2008
PubMed ID: 18781614
-
PTEN hamartoma tumor syndromes.
Blumenthal GM, Dennis PA
Eur J Hum Genet. 2008
PubMed ID: 18781191
-
Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression.
Laguë MN, Paquet M, Fan HY, Kaartinen MJ, Chu S, Jamin SP, Behringer RR, Fuller PJ, Mitchell A, Doré M, Huneault LM, Richards JS, Boerboom D
Carcinogenesis. 2008
PubMed ID: 18687666
-
Ischemia-reperfusion injury and cardioprotection: investigating PTEN, the phosphatase that negatively regulates PI3K, using a congenital model of PTEN haploinsufficiency.
Siddall HK, Warrell CE, Yellon DM, Mocanu MM
Basic Res Cardiol. 2008
PubMed ID: 18604624
-
Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells.
Estrada R, Zeng Q, Lu H, Sarojini H, Lee JF, Mathis SP, Sanchez T, Wang E, Kontos CD, Lin CY, Hla T, Haribabu B, Lee MJ
J Biol Chem. 2008
PubMed ID: 18765664
-
PI3K/Akt: getting it right matters.
Franke TF
Oncogene. 2008
PubMed ID: 18955974
-
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.
Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, DePinho RA
Nature. 2008
PubMed ID: 18948956
-
Is PTEN loss associated with clinical outcome measures in human prostate cancer?
McCall P, Witton CJ, Grimsley S, Nielsen KV, Edwards J
Br J Cancer. 2008
PubMed ID: 18854827
-
Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression.
Nishino J, Kim I, Chada K, Morrison SJ
Cell. 2008
PubMed ID: 18957199
-
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network.
Song MS, Salmena L, Carracedo A, Egia A, Lo-Coco F, Teruya-Feldstein J, Pandolfi PP
Nature. 2008
PubMed ID: 18716620
-
[The dynamic expression of PTEN in fibrogenic rat liver tissues and its relation to the activation and proliferation of hepatic stellate cells]
Hao LS, Zhang XL, Li YL, Tian XP, An JY
Zhonghua Gan Zang Bing Za Zhi. 2008
PubMed ID: 18983770
-
[Expression of tumor suppressor gene pten in patients with myelodysplastic syndrome and acute myeloid leukemia].
Zou XL, Liu T, Meng WT, Huang XO
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008
PubMed ID: 18928601
-
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
-
TGFbeta modulates PTEN expression independently of SMAD signaling for growth proliferation in colon cancer cells.
Chow JY, Cabral JA, Chang J, Carethers JM
Cancer Biol Ther. 2008
PubMed ID: 18769113
-
CSIG inhibits PTEN translation in replicative senescence.
Ma L, Chang N, Guo S, Li Q, Zhang Z, Wang W, Tong T
Mol Cell Biol. 2008
PubMed ID: 18678645
-
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
-
Resistance to TRAIL-induced apoptosis caused by constitutional phosphorylation of Akt and PTEN in acute lymphoblastic leukemia cells.
Dida F, Li Y, Iwao A, Deguchi T, Azuma E, Komada Y
Exp Hematol. 2008
PubMed ID: 18599181
-
Contribution of PTEN large rearrangements in Cowden disease: a multiplex amplifiable probe hybridisation (MAPH) screening approach.
Chibon F, Primois C, Bressieux JM, Lacombe D, Lok C, Mauriac L, Taieb A, Longy M
J Med Genet. 2008
PubMed ID: 18456716
-
The role of PTEN signaling perturbations in cancer and in targeted therapy.
Keniry M, Parsons R
Oncogene. 2008
PubMed ID: 18794882
-
PTEN: a new guardian of the genome.
Yin Y, Shen WH
Oncogene. 2008
PubMed ID: 18794879
-
The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey.
Knobbe CB, Lapin V, Suzuki A, Mak TW
Oncogene. 2008
PubMed ID: 18794876
-
Genetic and phenotypic heterogeneity in the PTEN hamartoma tumour syndrome.
Orloff MS, Eng C
Oncogene. 2008
PubMed ID: 18794875
-
ATP modulates PTEN subcellular localization in multiple cancer cell lines.
Lobo GP, Waite KA, Planchon SM, Romigh T, Houghton JA, Eng C
Hum Mol Genet. 2008
PubMed ID: 18579579
-
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A
Science. 2008
PubMed ID: 18787170
-
Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression.
Chandrasekar B, Boylston WH, Venkatachalam K, Webster NJ, Prabhu SD, Valente AJ
J Biol Chem. 2008
PubMed ID: 18632660
-
PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway.
Chan PM, Lim L, Manser E
J Biol Chem. 2008
PubMed ID: 18586681
-
PTEN-deficient cancers depend on PIK3CB.
Wee S, Wiederschain D, Maira SM, Loo A, Miller C, deBeaumont R, Stegmeier F, Yao YM, Lengauer C
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18755892
-
Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas.
Scheper MA, Chaisuparat R, Nikitakis NG, Sauk JJ
Oral Dis. 2008
PubMed ID: 18826385
-
Chemoprevention and treatment of experimental Cowden's disease by mTOR inhibition with rapamycin.
Squarize CH, Castilho RM, Gutkind JS
Cancer Res. 2008
PubMed ID: 18757421
-
PTEN acetylation modulates its interaction with PDZ domain.
Ikenoue T, Inoki K, Zhao B, Guan KL
Cancer Res. 2008
PubMed ID: 18757404
-
Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation.
Byron SA, Gartside MG, Wellens CL, Mallon MA, Keenan JB, Powell MA, Goodfellow PJ, Pollock PM
Cancer Res. 2008
PubMed ID: 18757403
-
Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls.
Fridberg M, Kjellström S, Anagnostaki L, Skogvall I, Mustelin T, Wiebe T, Persson JL, Dictor M, Wingren AG
Pediatr Hematol Oncol. 2008
PubMed ID: 18728972
-
Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model.
Kinkade CW, Castillo-Martin M, Puzio-Kuter A, Yan J, Foster TH, Gao H, Sun Y, Ouyang X, Gerald WL, Cordon-Cardo C, Abate-Shen C
J Clin Invest. 2008
PubMed ID: 18725989
-
Predictive value of PTEN and AR coexpression of sustained responsiveness to hormonal therapy in prostate cancer--a pilot study.
El Sheikh SS, Romanska HM, Abel P, Domin J, Lalani el-N
Neoplasia. 2008
PubMed ID: 18714395
-
SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis.
El-Bizri N, Guignabert C, Wang L, Cheng A, Stankunas K, Chang CP, Mishina Y, Rabinovitch M
Development. 2008
PubMed ID: 18667463
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Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells.
Fan HY, Liu Z, Cahill N, Richards JS
Mol Endocrinol. 2008
PubMed ID: 18606860
-
Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth.
John GB, Gallardo TD, Shirley LJ, Castrillon DH
Dev Biol. 2008
PubMed ID: 18601916
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Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation.
Wang X, Shi Y, Wang J, Huang G, Jiang X
Biochem J. 2008
PubMed ID: 18498243
-
Novel PTEN mutations in neurodevelopmental disorders and macrocephaly.
Orrico A, Galli L, Buoni S, Orsi A, Vonella G, Sorrentino V
Clin Genet. 2008
PubMed ID: 18759867
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Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.
Nardella C, Chen Z, Salmena L, Carracedo A, Alimonti A, Egia A, Carver B, Gerald W, Cordon-Cardo C, Pandolfi PP
Genes Dev. 2008
PubMed ID: 18708577
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Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx2.1 and Pten.
Xing Y, Li C, Hu L, Tiozzo C, Li M, Chai Y, Bellusci S, Anderson S, Minoo P
Dev Biol. 2008
PubMed ID: 18602626
-
Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.
Jia S, Liu Z, Zhang S, Liu P, Zhang L, Lee SH, Zhang J, Signoretti S, Loda M, Roberts TM, Zhao JJ
Nature. 2008
PubMed ID: 18594509
-
[The changes of PTEN/Akt1 expression and cell proliferation in pulmonary arterial smooth muscle cells induced by hypoxia in rats].
Yi B, Qian GS, Bai L
Zhonghua Jie He He Hu Xi Za Zhi. 2008
PubMed ID: 19080402
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[Expression of Skp2 and PTEN and its correlation in glottic carcinoma].
Zhao H, He X, Pu Z, Wang Q
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008
PubMed ID: 18950007
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Cellular commitment to reentry into the cell cycle after stalled DNA is determined by site-specific phosphorylation of Chk1 and PTEN.
Martin SA, Ouchi T
Mol Cancer Ther. 2008
PubMed ID: 18723495
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Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice.
Hollander MC, Balogh AR, Liwanag J, Han W, Linnoila RI, Anver MR, Dennis PA
Neoplasia. 2008
PubMed ID: 18683321
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An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, Neve RM, Kuo WL, Davies M, Carey M, Hu Z, Guan Y, Sahin A, Symmans WF, Pusztai L, Nolden LK, Horlings H, Berns K, Hung MC, van de Vijver MJ, Valero V, Gray JW, Bernards R, Mills GB, Hennessy BT
Cancer Res. 2008
PubMed ID: 18676830
-
Phosphatase and tensin homologue and pituitary tumor-transforming gene in pituitary adenomas. Clinical-pathologic and immunohistochemical analysis.
Tena-Suck ML, Ortiz-Plata A, de la Vega HA
Ann Diagn Pathol. 2008
PubMed ID: 18620995
-
First report of ovarian dysgerminoma in Cowden syndrome with germline PTEN mutation and PTEN-related 10q loss of tumor heterozygosity.
Cho MY, Kim HS, Eng C, Kim DS, Kang SJ, Eom M, Yi SY, Bronner MP
Am J Surg Pathol. 2008
PubMed ID: 18594467
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Variable phenotypes associated with 10q23 microdeletions involving the PTEN and BMPR1A genes.
Menko FH, Kneepkens CM, de Leeuw N, Peeters EA, Van Maldergem L, Kamsteeg EJ, Davidson R, Rozendaal L, Lasham CA, Peeters-Scholte CM, Jansweijer MC, Hilhorst-Hofstee Y, Gille JJ, Heins YM, Nieuwint AW, Sistermans EA
Clin Genet. 2008
PubMed ID: 18510548
-
Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells.
Ohtani M, Nagai S, Kondo S, Mizuno S, Nakamura K, Tanabe M, Takeuchi T, Matsuda S, Koyasu S
Blood. 2008
PubMed ID: 18492954
-
Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells.
Kikuno N, Shiina H, Urakami S, Kawamoto K, Hirata H, Tanaka Y, Majid S, Igawa M, Dahiya R
Int J Cancer. 2008
PubMed ID: 18431742
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PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients.
Perrone F, Lampis A, Orsenigo M, Di Bartolomeo M, Gevorgyan A, Losa M, Frattini M, Riva C, Andreola S, Bajetta E, Bertario L, Leo E, Pierotti MA, Pilotti S
Ann Oncol. 2008
PubMed ID: 18669866
-
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
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PTEN expression in endometrial biopsies as a marker of progression to endometrial carcinoma.
Lacey JV, Mutter GL, Ronnett BM, Ioffe OB, Duggan MA, Rush BB, Glass AG, Richesson DA, Chatterjee N, Langholz B, Sherman ME
Cancer Res. 2008
PubMed ID: 18632658
-
Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis.
Inoue-Narita T, Hamada K, Sasaki T, Hatakeyama S, Fujita S, Kawahara K, Sasaki M, Kishimoto H, Eguchi S, Kojima I, Beermann F, Kimura T, Osawa M, Itami S, Mak TW, Nakano T, Manabe M, Suzuki A
Cancer Res. 2008
PubMed ID: 18632629
-
Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice.
Daikoku T, Hirota Y, Tranguch S, Joshi AR, DeMayo FJ, Lydon JP, Ellenson LH, Dey SK
Cancer Res. 2008
PubMed ID: 18632614
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Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway.
Bu S, Kapanadze B, Hsu T, Trojanowska M
J Biol Chem. 2008
PubMed ID: 18482992
-
Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis.
Xia H, Diebold D, Nho R, Perlman D, Kleidon J, Kahm J, Avdulov S, Peterson M, Nerva J, Bitterman P, Henke C
J Exp Med. 2008
PubMed ID: 18541712
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Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.
Steelman LS, Navolanic PM, Sokolosky ML, Taylor JR, Lehmann BD, Chappell WH, Abrams SL, Wong EW, Stadelman KM, Terrian DM, Leslie NR, Martelli AM, Stivala F, Libra M, Franklin RA, McCubrey JA
Oncogene. 2008
PubMed ID: 18332865
-
Augmentation by carnosic acid of apoptosis in human leukaemia cells induced by arsenic trioxide via upregulation of the tumour suppressor PTEN.
Wang R, Li H, Guo G, Li X, Yu X, Li H, Wang J, Liu F, Chen X
J Int Med Res. 2008
PubMed ID: 18652763
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PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils.
Heit B, Robbins SM, Downey CM, Guan Z, Colarusso P, Miller BJ, Jirik FR, Kubes P
Nat Immunol. 2008
PubMed ID: 18536720
-
Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia.
Frew IJ, Minola A, Georgiev S, Hitz M, Moch H, Richard S, Vortmeyer AO, Krek W
Mol Cell Biol. 2008
PubMed ID: 18474617
-
Loss of Pten, a tumor suppressor, causes the strong inhibition of autophagy without affecting LC3 lipidation.
Ueno T, Sato W, Horie Y, Komatsu M, Tanida I, Yoshida M, Ohshima S, Mak TW, Watanabe S, Kominami E
Autophagy. 2008
PubMed ID: 18424911
-
Chromosomal imbalances, loss of heterozygosity, and immunohistochemical expression of TP53, RB1, and PTEN in intraductal cancer, intraepithelial neoplasia, and invasive adenocarcinoma of the prostate.
Bettendorf O, Schmidt H, Staebler A, Grobholz R, Heinecke A, Boecker W, Hertle L, Semjonow A
Genes Chromosomes Cancer. 2008
PubMed ID: 18383208
-
PCR-SSCP-DNA sequencing method in detecting PTEN gene mutation and its significance in human gastric cancer.
Guo CY, Xu XF, Wu JY, Liu SF
World J Gastroenterol. 2008
PubMed ID: 18609703
-
The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization.
Fouladkou F, Landry T, Kawabe H, Neeb A, Lu C, Brose N, Stambolic V, Rotin D
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18562292
-
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
Frew IJ, Thoma CR, Georgiev S, Minola A, Hitz M, Montani M, Moch H, Krek W
EMBO J. 2008
PubMed ID: 18497742
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PTEN loss does not predict for response to RAD001 (Everolimus) in a glioblastoma orthotopic xenograft test panel.
Yang L, Clarke MJ, Carlson BL, Mladek AC, Schroeder MA, Decker P, Wu W, Kitange GJ, Grogan PT, Goble JM, Uhm J, Galanis E, Giannini C, Lane HA, James CD, Sarkaria JN
Clin Cancer Res. 2008
PubMed ID: 18559622
-
The expression of mammalian target of rapamycin in Ishikawa and HEC-1A cells.
Li X, Xiao L, Yang Y, Shen H, Zeng H, Wang Z
J Huazhong Univ Sci Technolog Med Sci. 2008
PubMed ID: 18563337
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Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas.
Thorarinsdottir HK, Santi M, McCarter R, Rushing EJ, Cornelison R, Jales A, MacDonald TJ
Clin Cancer Res. 2008
PubMed ID: 18519768
-
PTEN expression and methylation status in oral squamous cell carcinoma.
Kurasawa Y, Shiiba M, Nakamura M, Fushimi K, Ishigami T, Bukawa H, Yokoe H, Uzawa K, Tanzawa H
Oncol Rep. 2008
PubMed ID: 18497947
-
Rapamycin treatment for a child with germline PTEN mutation.
Marsh DJ, Trahair TN, Martin JL, Chee WY, Walker J, Kirk EP, Baxter RC, Marshall GM
Nat Clin Pract Oncol. 2008
PubMed ID: 18431376
-
PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex.
Woiwode A, Johnson SA, Zhong S, Zhang C, Roeder RG, Teichmann M, Johnson DL
Mol Cell Biol. 2008
PubMed ID: 18391023
-
PPARbeta/delta agonist stimulates human lung carcinoma cell growth through inhibition of PTEN expression: the involvement of PI3K and NF-kappaB signals.
Han S, Ritzenthaler JD, Zheng Y, Roman J
Am J Physiol Lung Cell Mol Physiol. 2008
PubMed ID: 18390835
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Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice.
Huang X, Wullschleger S, Shpiro N, McGuire VA, Sakamoto K, Woods YL, McBurnie W, Fleming S, Alessi DR
Biochem J. 2008
PubMed ID: 18387000
-
Hepatic insulin resistance induced by prenatal alcohol exposure is associated with reduced PTEN and TRB3 acetylation in adult rat offspring.
Yao XH, Nyomba BL
Am J Physiol Regul Integr Comp Physiol. 2008
PubMed ID: 18385463
-
A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer.
Hellwinkel OJ, Rogmann JP, Asong LE, Luebke AM, Eichelberg C, Ahyai S, Isbarn H, Graefen M, Huland H, Schlomm T
BJU Int. 2008
PubMed ID: 18336616
-
The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.
Ahn Y, Hwang CY, Lee SR, Kwon KS, Lee C
Biochem J. 2008
PubMed ID: 18307411
-
Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress.
Oudit GY, Kassiri Z, Zhou J, Liu QC, Liu PP, Backx PH, Dawood F, Crackower MA, Scholey JW, Penninger JM
Cardiovasc Res. 2008
PubMed ID: 18281373
-
GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis.
Shu CW, Sun FC, Cho JH, Lin CC, Liu PF, Chen PY, Chang MD, Fu HW, Lai YK
J Cell Physiol. 2008
PubMed ID: 18064632
-
Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifen.
Turbiner J, Moreno-Bueno G, Dahiya S, Sánchez-Estevez C, Hardisson D, Prat J, Oliva E, Palacios J
Mod Pathol. 2008
PubMed ID: 18500270
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Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation.
Guo W, Lasky JL, Chang CJ, Mosessian S, Lewis X, Xiao Y, Yeh JE, Chen JY, Iruela-Arispe ML, Varella-Garcia M, Wu H
Nature. 2008
PubMed ID: 18463637
-
Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21 WAF-induced differentiation triggered by GSK3beta inactivation and reduced AKT activity.
Yao D, Alexander CL, Quinn JA, Chan WC, Wu H, Greenhalgh DA
J Cell Sci. 2008
PubMed ID: 18445683
-
Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma.
Dal Col J, Zancai P, Terrin L, Guidoboni M, Ponzoni M, Pavan A, Spina M, Bergamin S, Rizzo S, Tirelli U, De Rossi A, Doglioni C, Dolcetti R
Blood. 2008
PubMed ID: 18339899
-
Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha.
Nemenoff RA, Simpson PA, Furgeson SB, Kaplan-Albuquerque N, Crossno J, Garl PJ, Cooper J, Weiser-Evans MC
Circ Res. 2008
PubMed ID: 18340011
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Incidentally simultaneous occurrence of RET/PTC, H4-PTEN and BRAF mutation in papillary thyroid carcinoma.
Wang YL, Wang JC, Wu Y, Zhang L, Huang CP, Shen Q, Zhu YX, Li DS, Ji QH
Cancer Lett. 2008
PubMed ID: 18226854
-
[Promoter methylation status of PTEN gene and the effect of induced demethylation in leukemia cell lines]
Li M, Liu H, Xu ZF, Liu XR, Wang Y, Rao Q, Wang JX, Wang M
Zhonghua Xue Ye Xue Za Zhi. 2008
PubMed ID: 18844062
-
[Role of PTEN protein in multidrug resistance of prostate cancer cells]
Sherbakova EA, Stromskaia TP, Rybalkina EIu, Kalita OV, Stavrovskaia AA
Mol Biol (Mosk). 2008
PubMed ID: 18702307
-
N-myc downstream-regulated gene 1 as a downregulated target gene of PTEN in the controlling of tumourigenesis in endometrioid carcinoma.
Li S, Chen J, Yang Z, Lu G, Tang H, Hu H
Indian J Med Res. 2008
PubMed ID: 18653908
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Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in Cowden syndrome.
Pezzolesi MG, Platzer P, Waite KA, Eng C
Am J Hum Genet. 2008
PubMed ID: 18460397
-
Pten haploinsufficiency accelerates formation of high-grade astrocytomas.
Kwon CH, Zhao D, Chen J, Alcantara S, Li Y, Burns DK, Mason RP, Lee EY, Wu H, Parada LF
Cancer Res. 2008
PubMed ID: 18451155
-
PTEN and p27Kip1 are not downregulated in the majority of renal cell carcinomas--implications for Akt activation.
Hennenlotter J, Ohneseit PA, Simon P, Merseburger AS, Serth J, Kuehs U, Kramer M, Hartmann JT, Stenzl A, Kuczyk MA
Oncol Rep. 2008
PubMed ID: 18425369
-
Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages.
Kuroda S, Nishio M, Sasaki T, Horie Y, Kawahara K, Sasaki M, Natsui M, Matozaki T, Tezuka H, Ohteki T, Förster I, Mak TW, Nakano T, Suzuki A
Eur J Immunol. 2008
PubMed ID: 18398930
-
Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells.
Feutz AC, Barrandon Y, Monard D
J Cell Sci. 2008
PubMed ID: 18398001
-
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking.
Sinclair LV, Finlay D, Feijoo C, Cornish GH, Gray A, Ager A, Okkenhaug K, Hagenbeek TJ, Spits H, Cantrell DA
Nat Immunol. 2008
PubMed ID: 18391955
-
TLR4/CD14-mediated PI3K activation is an essential component of interferon-dependent VSV resistance in macrophages.
Schabbauer G, Luyendyk J, Crozat K, Jiang Z, Mackman N, Bahram S, Georgel P
Mol Immunol. 2008
PubMed ID: 18339426
-
PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression.
Chang CJ, Mulholland DJ, Valamehr B, Mosessian S, Sellers WR, Wu H
Mol Cell Biol. 2008
PubMed ID: 18332125
-
The AP-2alpha transcription factor is required for the ganglioside GM3-stimulated transcriptional regulation of a PTEN gene.
Choi HJ, Chung TW, Kim SJ, Cho SY, Lee YS, Lee YC, Ko JH, Kim CH
Glycobiology. 2008
PubMed ID: 18316341
-
Large genomic deletions of SMAD4, BMPR1A and PTEN in juvenile polyposis.
van Hattem WA, Brosens LA, de Leng WW, Morsink FH, Lens S, Carvalho R, Giardiello FM, Offerhaus GJ
Gut. 2008
PubMed ID: 18178612
-
Presenilins regulate the cellular level of the tumor suppressor PTEN.
Zhang H, Liu R, Wang R, Hong S, Xu H, Zhang YW
Neurobiol Aging. 2008
PubMed ID: 17222949
-
PTEN deletion leads to deregulation of antioxidants and increased oxidative damage in mouse embryonic fibroblasts.
Huo YY, Li G, Duan RF, Gou Q, Fu CL, Hu YC, Song BQ, Yang ZH, Wu DC, Zhou PK
Free Radic Biol Med. 2008
PubMed ID: 18275859
-
Peripubertal hyperinsulinemia upregulates phosphatidylinositol 3-kinase/akt pathway in rat ovaries.
Chakrabarty S, Nagamani M
Reprod Sci. 2008
PubMed ID: 18421022
-
Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis.
Dourdin N, Schade B, Lesurf R, Hallett M, Munn RJ, Cardiff RD, Muller WJ
Cancer Res. 2008
PubMed ID: 18381417
-
Correlation between NDRG1 and PTEN expression in endometrial carcinoma.
Chen J, Li S, Yang Z, Lu G, Hu H
Cancer Sci. 2008
PubMed ID: 18377423
-
Antigen-induced Pten gene deletion in T cells exacerbates neuropathology in experimental autoimmune encephalomyelitis.
Johnson TA, Tsutsui S, Jirik FR
Am J Pathol. 2008
PubMed ID: 18349128
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Utility of thin-layer preparations in endometrial cytology: immunocytochemical expression of PTEN, beta-catenin and p53 for benign endometrial lesions.
Norimatsu Y, Miyamoto T, Kobayashi TK, Oda T, Moriya T, Yanoh K, Miyake Y, Ohno E
Diagn Cytopathol. 2008
PubMed ID: 18335551
-
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes.
Xiao C, Srinivasan L, Calado DP, Patterson HC, Zhang B, Wang J, Henderson JM, Kutok JL, Rajewsky K
Nat Immunol. 2008
PubMed ID: 18327259
-
TGF-beta mediates PTEN suppression and cell motility through calcium-dependent PKC-alpha activation in pancreatic cancer cells.
Chow JY, Dong H, Quach KT, Van Nguyen PN, Chen K, Carethers JM
Am J Physiol Gastrointest Liver Physiol. 2008
PubMed ID: 18239055
-
Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development.
Cho KW, Cho SW, Lee JM, Lee MJ, Gang HS, Jung HS
Gene Expr Patterns. 2008
PubMed ID: 18203667
-
Regulation of the PTEN promoter by statins and SREBP.
Teresi RE, Planchon SM, Waite KA, Eng C
Hum Mol Genet. 2008
PubMed ID: 18065496
-
Inhibition of apoptosis by MAD1 is mediated by repression of the PTEN tumor suppressor gene.
Rottmann S, Speckgens S, Lüscher-Firzlaff J, Lüscher B
FASEB J. 2008
PubMed ID: 17998413
-
The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration.
Dey N, Crosswell HE, De P, Parsons R, Peng Q, Su JD, Durden DL
Cancer Res. 2008
PubMed ID: 18339867
-
PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations.
Li Y, Guessous F, Kwon S, Kumar M, Ibidapo O, Fuller L, Johnson E, Lal B, Hussaini I, Bao Y, Laterra J, Schiff D, Abounader R
Cancer Res. 2008
PubMed ID: 18339852
-
Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages.
Luyendyk JP, Schabbauer GA, Tencati M, Holscher T, Pawlinski R, Mackman N
J Immunol. 2008
PubMed ID: 18322234
-
Txnip balances metabolic and growth signaling via PTEN disulfide reduction.
Hui ST, Andres AM, Miller AK, Spann NJ, Potter DW, Post NM, Chen AZ, Sachithanantham S, Jung DY, Kim JK, Davis RA
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18322014
-
Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis.
Escrivà M, Peiró S, Herranz N, Villagrasa P, Dave N, Montserrat-Sentís B, Murray SA, Francí C, Gridley T, Virtanen I, García de Herreros A
Mol Cell Biol. 2008
PubMed ID: 18172008
-
T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus.
Hagenbeek TJ, Spits H
Leukemia. 2008
PubMed ID: 18046443
-
Conditional deletion of Pten causes bronchiolar hyperplasia.
Davé V, Wert SE, Tanner T, Thitoff AR, Loudy DE, Whitsett JA
Am J Respir Cell Mol Biol. 2008
PubMed ID: 17921358
-
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).
Emerling BM, Weinberg F, Liu JL, Mak TW, Chandel NS
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18268343
-
Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma.
Ratnacaram CK, Teletin M, Jiang M, Meng X, Chambon P, Metzger D
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18268330
-
PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes.
Redfern RE, Redfern D, Furgason ML, Munson M, Ross AH, Gericke A
Biochemistry. 2008
PubMed ID: 18220422
-
Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer.
Iwanaga K, Yang Y, Raso MG, Ma L, Hanna AE, Thilaganathan N, Moghaddam S, Evans CM, Li H, Cai WW, Sato M, Minna JD, Wu H, Creighton CJ, Demayo FJ, Wistuba II, Kurie JM
Cancer Res. 2008
PubMed ID: 18281487
-
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice.
Xue L, Nolla H, Suzuki A, Mak TW, Winoto A
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18250301
-
A causal role for ERG in neoplastic transformation of prostate epithelium.
Klezovitch O, Risk M, Coleman I, Lucas JM, Null M, True LD, Nelson PS, Vasioukhin V
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18245377
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Utility of EGFR and PTEN numerical aberrations in the evaluation of diffusely infiltrating astrocytomas. Laboratory investigation.
Mott RT, Turner KC, Bigner DD, McLendon RE
J Neurosurg. 2008
PubMed ID: 18240930
-
Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation.
Chi JH, Panner A, Cachola K, Crane CA, Murray J, Pieper RO, James CD, Parsa AT
J Neurosurg. 2008
PubMed ID: 18240926
-
Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool.
Reddy P, Liu L, Adhikari D, Jagarlamudi K, Rajareddy S, Shen Y, Du C, Tang W, Hämäläinen T, Peng SL, Lan ZJ, Cooney AJ, Huhtaniemi I, Liu K
Science. 2008
PubMed ID: 18239123
-
The nuclear affairs of PTEN.
Planchon SM, Waite KA, Eng C
J Cell Sci. 2008
PubMed ID: 18216329
-
Portrait of PTEN: messages from mutant mice.
Suzuki A, Nakano T, Mak TW, Sasaki T
Cancer Sci. 2008
PubMed ID: 18201277
-
Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.
Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T
Rheumatology (Oxford). 2008
PubMed ID: 18174230
-
Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities.
Fraser MM, Bayazitov IT, Zakharenko SS, Baker SJ
Neuroscience. 2008
PubMed ID: 18082964
-
Mammalian target of rapamycin is the key effector of phosphatidylinositol-3-OH-initiated proliferative signals in the thyroid follicular epithelium.
Yeager N, Brewer C, Cai KQ, Xu XX, Di Cristofano A
Cancer Res. 2008
PubMed ID: 18199538
-
MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN.
Yang H, Kong W, He L, Zhao JJ, O'Donnell JD, Wang J, Wenham RM, Coppola D, Kruk PA, Nicosia SV, Cheng JQ
Cancer Res. 2008
PubMed ID: 18199536
-
The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells.
Janas ML, Hodson D, Stamataki Z, Hill S, Welch K, Gambardella L, Trotman LC, Pandolfi PP, Vigorito E, Turner M
J Immunol. 2008
PubMed ID: 18178811
-
Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma.
Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, dePinho RA
Cold Spring Harb Symp Quant Biol. 2008
PubMed ID: 19150964
-
PTEN polymorphisms and the risk of esophageal carcinoma and gastric cardiac carcinoma in a high incidence region of China.
Ge H, Cao YY, Chen LQ, Wang YM, Chen ZF, Wen DG, Zhang XF, Guo W, Wang N, Li Y, Zhang JH
Dis Esophagus. 2008
PubMed ID: 19125794
-
The pace of prostatic intraepithelial neoplasia development is determined by the timing of Pten tumor suppressor gene excision.
Luchman HA, Benediktsson H, Villemaire ML, Peterson AC, Jirik FR
PLoS ONE. 2008
PubMed ID: 19081794
-
Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells.
Marty B, Maire V, Gravier E, Rigaill G, Vincent-Salomon A, Kappler M, Lebigot I, Djelti F, Tourdès A, Gestraud P, Hupé P, Barillot E, Cruzalegui F, Tucker GC, Stern MH, Thiery JP, Hickman JA, Dubois T
Breast Cancer Res. 2008
PubMed ID: 19055754
-
Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival.
Sawai H, Yasuda A, Ochi N, Ma J, Matsuo Y, Wakasugi T, Takahashi H, Funahashi H, Sato M, Takeyama H
BMC Gastroenterol. 2008
PubMed ID: 19036165
-
Genome wide identification of recessive cancer genes by combinatorial mutation analysis.
Volinia S, Mascellani N, Marchesini J, Veronese A, Ormondroyd E, Alder H, Palatini J, Negrini M, Croce CM
PLoS ONE. 2008
PubMed ID: 18846217
-
Potential value of PTEN in predicting cetuximab response in colorectal cancer: an exploratory study.
Razis E, Briasoulis E, Vrettou E, Skarlos DV, Papamichael D, Kostopoulos I, Samantas E, Xanthakis I, Bobos M, Galanidi E, Bai M, Gikonti I, Koukouma A, Kafiri G, Papakostas P, Kalogeras KT, Kosmidis P, Fountzilas G
BMC Cancer. 2008
PubMed ID: 18700047
-
Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer.
Yang Y, Iwanaga K, Raso MG, Wislez M, Hanna AE, Wieder ED, Molldrem JJ, Wistuba II, Powis G, Demayo FJ, Kim CF, Kurie JM
PLoS ONE. 2008
PubMed ID: 18493606
-
APE1/Ref-1 regulates PTEN expression mediated by Egr-1.
Fantini D, Vascotto C, Deganuto M, Bivi N, Gustincich S, Marcon G, Quadrifoglio F, Damante G, Bhakat KK, Mitra S, Tell G
Free Radic Res. 2008
PubMed ID: 18324520
-
[Expression of survivin, p27 and PTEN in hepatocellular carcinoma and their clinical significances]
Huang AM, Ding Y, Liu JF, Gao LY, Zang SB, Chen SP
Zhonghua Gan Zang Bing Za Zhi. 2008
PubMed ID: 18226337
-
Tissue microarray based analysis of prognostic markers in invasive bladder cancer: much effort to no avail?
Liedberg F, Anderson H, Chebil G, Gudjonsson S, Höglund M, Lindgren D, Lundberg LM, Lövgren K, Fernö M, Månsson W
Urol Oncol. 2008
PubMed ID: 18190825
-
Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells.
Pan Y, Weinman EJ, Dai JL
Breast Cancer Res. 2008
PubMed ID: 18190691
-
PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism.
Vinciguerra M, Veyrat-Durebex C, Moukil MA, Rubbia-Brandt L, Rohner-Jeanrenaud F, Foti M
Gastroenterology. 2008
PubMed ID: 18166358
-
Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis.
Dihal AA, van der Woude H, Hendriksen PJ, Charif H, Dekker LJ, Ijsselstijn L, de Boer VC, Alink GM, Burgers PC, Rietjens IM, Woutersen RA, Stierum RH
Proteomics. 2008
PubMed ID: 18095365
-
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.
Saal LH, Gruvberger-Saal SK, Persson C, Lövgren K, Jumppanen M, Staaf J, Jönsson G, Pires MM, Maurer M, Holm K, Koujak S, Subramaniyam S, Vallon-Christersson J, Olsson H, Su T, Memeo L, Ludwig T, Ethier SP, Krogh M, Szabolcs M, Murty VV, Isola J, Hibshoosh H, Parsons R, Borg A
Nat Genet. 2008
PubMed ID: 18066063
-
Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells.
Zeiser R, Leveson-Gower DB, Zambricki EA, Kambham N, Beilhack A, Loh J, Hou JZ, Negrin RS
Blood. 2008
PubMed ID: 17967941
-
Expression and clinical role of DJ-1, a negative regulator of PTEN, in ovarian carcinoma.
Davidson B, Hadar R, Schlossberg A, Sternlicht T, Slipicevic A, Skrede M, Risberg B, Flørenes VA, Kopolovic J, Reich R
Hum Pathol. 2008
PubMed ID: 17949781
-
Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain.
Li W, Sun G, Yang S, Qu Q, Nakashima K, Shi Y
Mol Endocrinol. 2008
PubMed ID: 17901127
-
Increased Rac activity is required for the progression of T-lymphomas induced by Pten-deficiency.
Strumane K, Song JY, Baas I, Collard JG
Leuk Res. 2008
PubMed ID: 17521720
-
Activation of phosphatase and tensin homolog on chromosome 10 mediates the inhibition of FcgammaR phagocytosis by prostaglandin E2 in alveolar macrophages.
Canetti C, Serezani CH, Atrasz RG, White ES, Aronoff DM, Peters-Golden M
J Immunol. 2007
PubMed ID: 18056380
-
[The mitochondrial localization of tumor suppressor PTEN promotes apoptosis in A431 cells]
Yue XJ, Song WD, Jiang XJ
Wei Sheng Wu Xue Bao. 2007
PubMed ID: 18271247
-
[Gene rearrangement analysis of papillary thyroid carcinoma].
Wang YL, Wang JC, Li DS, Zhu YX, Wu Y, Ji QH
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007
PubMed ID: 18335752
-
[Research of the expression of PTEN in squamous cell carcinoma of larynx by the tissue chip technology].
Wang S, Liu F, Li X, Dong P
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007
PubMed ID: 18260377
-
Reversal of multidrug resistance and inhibition of phosphorylation of AKT in human ovarian cancer cell line by wild-type PTEN gene.
Wu H, Weng D, Xing H
J Huazhong Univ Sci Technolog Med Sci. 2007
PubMed ID: 18231751
-
Homeoprotein Cdx2 and nuclear PTEN expression profiles are related to gastric cancer prognosis.
Bai Z, Ye Y, Chen D, Shen D, Xu F, Cui Z, Wang S
APMIS. 2007
PubMed ID: 18184409
-
Low expression of FHIT and PTEN correlates with malignancy of gastric carcinomas: tissue-array findings.
Zheng H, Takahashi H, Murai Y, Cui Z, Nomoto K, Tsuneyama K, Takano Y
Appl Immunohistochem Mol Morphol. 2007
PubMed ID: 18091387
-
Aging gastropathy-novel mechanisms: hypoxia, up-regulation of multifunctional phosphatase PTEN, and proapoptotic factors.
Tarnawski A, Pai R, Deng X, Ahluwalia A, Khomenko T, Tanigawa T, Akahoshi T, Sandor Z, Szabo S
Gastroenterology. 2007
PubMed ID: 18054565
-
Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation.
Plum L, Rother E, Münzberg H, Wunderlich FT, Morgan DA, Hampel B, Shanabrough M, Janoschek R, Könner AC, Alber J, Suzuki A, Krone W, Horvath TL, Rahmouni K, Brüning JC
Cell Metab. 2007
PubMed ID: 18054313
-
Androgen signaling and its interactions with other signaling pathways in prostate cancer.
Kaarbø M, Klokk TI, Saatcioglu F
Bioessays. 2007
PubMed ID: 18008377
-
Down-regulation of tumor suppressor gene PTEN, overexpression of p53, plus high proliferating cell nuclear antigen index predict poor patient outcome of hepatocellular carcinoma after resection.
Hu TH, Wang CC, Huang CC, Chen CL, Hung CH, Chen CH, Wang JH, Lu SN, Lee CM, Changchien CS, Tai MH
Oncol Rep. 2007
PubMed ID: 17982625
-
Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss.
Mori N, Kyo S, Sakaguchi J, Mizumoto Y, Ohno S, Maida Y, Hashimoto M, Takakura M, Inoue M
Cancer Sci. 2007
PubMed ID: 17924977
-
Serum withdrawal-induced accumulation of phosphoinositide 3-kinase lipids in differentiating 3T3-L6 myoblasts: distinct roles for Ship2 and PTEN.
Mandl A, Sarkes D, Carricaburu V, Jung V, Rameh L
Mol Cell Biol. 2007
PubMed ID: 17893321
-
Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells.
Freeley M, Park J, Yang KJ, Wange RL, Volkov Y, Kelleher D, Long A
Cell Signal. 2007
PubMed ID: 17826953
-
PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis.
Fang J, Ding M, Yang L, Liu LZ, Jiang BH
Cell Signal. 2007
PubMed ID: 17826033
-
Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin.
Shao J, Washington MK, Saxena R, Sheng H
Carcinogenesis. 2007
PubMed ID: 17693663
-
Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade.
Liu JL, Mao Z, LaFortune TA, Alonso MM, Gallick GE, Fueyo J, Yung WK
Cancer Res. 2007
PubMed ID: 18006852
-
PTEN down-regulates IL-17 expression in a murine model of toluene diisocyanate-induced airway disease.
Kim SR, Lee KS, Park SJ, Min KH, Lee KY, Choe YH, Lee YR, Kim JS, Hong SJ, Lee YC
J Immunol. 2007
PubMed ID: 17982072
-
Restoring E-cadherin-mediated cell-cell adhesion increases PTEN protein level and stability in human breast carcinoma cells.
Li Z, Wang L, Zhang W, Fu Y, Zhao H, Hu Y, Prins BP, Zha X
Biochem Biophys Res Commun. 2007
PubMed ID: 17845801
-
[Expression and significance of Notch1 and PTEN in gastric cancer]
Li DW, Wu Q, Peng ZH, Yang ZR, Wang Y
Ai Zheng. 2007
PubMed ID: 17991315
-
Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras.
Vasudevan KM, Burikhanov R, Goswami A, Rangnekar VM
Cancer Res. 2007
PubMed ID: 17974977
-
Phosphatase PTEN in neuronal injury and brain disorders.
Chang N, El-Hayek YH, Gomez E, Wan Q
Trends Neurosci. 2007
PubMed ID: 17959258
-
PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors.
Noro R, Gemma A, Miyanaga A, Kosaihira S, Minegishi Y, Nara M, Kokubo Y, Seike M, Kataoka K, Matsuda K, Okano T, Yoshimura A, Kudoh S
Int J Oncol. 2007
PubMed ID: 17912443
-
MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells.
Hu Y, Li Z, Guo L, Wang L, Zhang L, Cai X, Zhao H, Zha X
Arch Biochem Biophys. 2007
PubMed ID: 17880912
-
High proportion of large genomic deletions and a genotype phenotype update in 80 unrelated families with juvenile polyposis syndrome.
Aretz S, Stienen D, Uhlhaas S, Stolte M, Entius MM, Loff S, Back W, Kaufmann A, Keller KM, Blaas SH, Siebert R, Vogt S, Spranger S, Holinski-Feder E, Sunde L, Propping P, Friedl W
J Med Genet. 2007
PubMed ID: 17873119
-
Investigate the role of PTEN in chemotaxis of human breast cancer cells.
Wan W, Zou H, Sun R, Liu Y, Wang J, Ma D, Zhang N
Cell Signal. 2007
PubMed ID: 17761400
-
The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death.
Yim JH, Kim YJ, Ko JH, Cho YE, Kim SM, Kim JY, Lee S, Park JH
Cell Death Differ. 2007
PubMed ID: 17657248
-
PIK3CA mutations are mutually exclusive with PTEN loss in diffuse large B-cell lymphoma.
Abubaker J, Bavi PP, Al-Harbi S, Siraj AK, Al-Dayel F, Uddin S, Al-Kuraya K
Leukemia. 2007
PubMed ID: 17657213
-
RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells.
Chow JY, Quach KT, Cabrera BL, Cabral JA, Beck SE, Carethers JM
Carcinogenesis. 2007
PubMed ID: 17638924
-
PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients.
Frattini M, Saletti P, Romagnani E, Martin V, Molinari F, Ghisletta M, Camponovo A, Etienne LL, Cavalli F, Mazzucchelli L
Br J Cancer. 2007
PubMed ID: 17940504
-
Mutation of the PTEN gene in a human hepatic angiosarcoma.
Tate G, Suzuki T, Mitsuya T
Cancer Genet Cytogenet. 2007
PubMed ID: 17954274
-
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance.
Zhou J, Wulfkuhle J, Zhang H, Gu P, Yang Y, Deng J, Margolick JB, Liotta LA, Petricoin E, Zhang Y
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17911267
-
Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner.
Song P, Wu Y, Xu J, Xie Z, Dong Y, Zhang M, Zou MH
Circulation. 2007
PubMed ID: 17875968
-
HoxA5 stabilizes adherens junctions via increased Akt1.
Arderiu G, Cuevas I, Chen A, Carrio M, East L, Boudreau NJ
Cell Adh Migr. 2007
PubMed ID: 19262140
-
Expression of proliferative and preapoptotic molecules in human myometrium and leiomyoma throughout the menstrual cycle.
Kayisli UA, Berkkanoglu M, Kizilay G, Senturk L, Arici A
Reprod Sci. 2007
PubMed ID: 18000229
-
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
Berns K, Horlings HM, Hennessy BT, Madiredjo M, Hijmans EM, Beelen K, Linn SC, Gonzalez-Angulo AM, Stemke-Hale K, Hauptmann M, Beijersbergen RL, Mills GB, van de Vijver MJ, Bernards R
Cancer Cell. 2007
PubMed ID: 17936563
-
Overexpression of PTEN induces cell growth arrest and apoptosis in human breast cancer ZR-75-1 cells.
Li X, Lin G, Wu B, Zhou X, Zhou K
Acta Biochim Biophys Sin (Shanghai). 2007
PubMed ID: 17928923
-
[Expression and clinical significance of survivin and PTEN in adrenal tumors]
Qin ZK, Zhou FJ, Dai YP, Chen W, Hou JH, Han H, Liu ZW, Yu SL, Zhang DZ, Yang JA
Ai Zheng. 2007
PubMed ID: 17927889
-
[Inhibitory effects of tumor suppressor gene PTEN on proliferation and metastasis of breast cancer ZR-75-1 cells]
Lin GP, Li XY, Huang JW, Xiong L, Zhou KY
Ai Zheng. 2007
PubMed ID: 17927875
-
PTEN and VEGF: possible predictors for sentinel lymph node micro-metastasis in breast cancer.
Zhu L, Loo WT, Louis WC
Biomed Pharmacother. 2007
PubMed ID: 17919877
-
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice.
Yanagi S, Kishimoto H, Kawahara K, Sasaki T, Sasaki M, Nishio M, Yajima N, Hamada K, Horie Y, Kubo H, Whitsett JA, Mak TW, Nakano T, Nakazato M, Suzuki A
J Clin Invest. 2007
PubMed ID: 17909629
-
Prolonged exposure to reduced levels of androgen accelerates prostate cancer progression in Nkx3.1; Pten mutant mice.
Banach-Petrosky W, Jessen WJ, Ouyang X, Gao H, Rao J, Quinn J, Aronow BJ, Abate-Shen C
Cancer Res. 2007
PubMed ID: 17909013
-
Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency.
Lu CH, Wyszomierski SL, Tseng LM, Sun MH, Lan KH, Neal CL, Mills GB, Hortobagyi GN, Esteva FJ, Yu D
Clin Cancer Res. 2007
PubMed ID: 17908983
-
Loss of heterozygosity analysis identifies genetic abnormalities in mycosis fungoides and specific loci associated with disease progression.
Katona TM, O'Malley DP, Cheng L, Hiatt KM, Wang M, Anagnostou JJ, Billings SD, Smoller BR
Am J Surg Pathol. 2007
PubMed ID: 17895757
-
PTEN expression in renal cell carcinoma and oncocytoma and prognosis.
Hager M, Haufe H, Kemmerling R, Mikuz G, Kolbitsch C, Moser PL
Pathology. 2007
PubMed ID: 17886097
-
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal AM, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons R, Zúñiga-Pflücker JC, Dominguez M, Ferrando AA
Nat Med. 2007
PubMed ID: 17873882
-
Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation.
Teresi RE, Zbuk KM, Pezzolesi MG, Waite KA, Eng C
Am J Hum Genet. 2007
PubMed ID: 17847000
-
Loss of heterozygosity on chromosome 10q23 and mutation of the phosphatase and tensin homolog deleted from chromosome 10 tumor suppressor gene in Korean hepatocellular carcinoma patients.
Bae JJ, Rho JW, Lee TJ, Yun SS, Kim HJ, Choi JH, Jeong D, Jang BC, Lee TY
Oncol Rep. 2007
PubMed ID: 17786367
-
Co-existence of high levels of the PTEN protein with enhanced Akt activation in renal cell carcinoma.
He L, Fan C, Gillis A, Feng X, Sanatani M, Hotte S, Kapoor A, Tang D
Biochim Biophys Acta. 2007
PubMed ID: 17681738
-
PTEN expression contributes to the regulation of muscle protein degradation in diabetes.
Hu Z, Lee IH, Wang X, Sheng H, Zhang L, Du J, Mitch WE
Diabetes. 2007
PubMed ID: 17623817
-
Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway.
Cesaratto L, Calligaris SD, Vascotto C, Deganuto M, Bellarosa C, Quadrifoglio F, Ostrow JD, Tiribelli C, Tell G
J Mol Med. 2007
PubMed ID: 17479230
-
EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression.
Selvendiran K, Tong L, Vishwanath S, Bratasz A, Trigg NJ, Kutala VK, Hideg K, Kuppusamy P
J Biol Chem. 2007
PubMed ID: 17684018
-
Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation.
Sun G, Yu RT, Evans RM, Shi Y
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17873065
-
Expression of PTEN, PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissues.
Wu SK, Wang BJ, Yang Y, Feng XH, Zhao XP, Yang DL
World J Gastroenterol. 2007
PubMed ID: 17729405
-
A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice.
Ogawa S, Kwon CH, Zhou J, Koovakkattu D, Parada LF, Sinton CM
Brain Res. 2007
PubMed ID: 17706614
-
FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome.
Yoshimoto M, Cunha IW, Coudry RA, Fonseca FP, Torres CH, Soares FA, Squire JA
Br J Cancer. 2007
PubMed ID: 17700571
-
CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells.
Opavsky R, Wang SH, Trikha P, Raval A, Huang Y, Wu YZ, Rodriguez B, Keller B, Liyanarachchi S, Wei G, Davuluri RV, Weinstein M, Felsher D, Ostrowski M, Leone G, Plass C
PLoS Genet. 2007
PubMed ID: 17907813
-
PTEN: its deregulation and tumorigenesis.
Maehama T
Biol Pharm Bull. 2007
PubMed ID: 17827710
-
PIK3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastatic to kidney.
Vranić S, Bilalović N, Lee LM, Kruslin B, Lilleberg SL, Gatalica Z
Hum Pathol. 2007
PubMed ID: 17669465
-
A reappraisal by quantitative flow cytometry analysis of PTEN expression in acute leukemia.
Yang J, Liu J, Zheng J, Du W, He Y, Liu W, Huang S
Leukemia. 2007
PubMed ID: 17611573
-
[Kidney tumors]
Thüroff JW
Urologe A. 2007
PubMed ID: 17593340
-
The spectrum of vascular anomalies in patients with PTEN mutations: implications for diagnosis and management.
Tan WH, Baris HN, Burrows PE, Robson CD, Alomari AI, Mulliken JB, Fishman SJ, Irons MB
J Med Genet. 2007
PubMed ID: 17526801
-
IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells.
Perks CM, Vernon EG, Rosendahl AH, Tonge D, Holly JM
Oncogene. 2007
PubMed ID: 17369847
-
Regulation of PTEN expression in intestinal epithelial cells by c-Jun NH2-terminal kinase activation and nuclear factor-kappaB inhibition.
Wang Q, Zhou Y, Wang X, Chung DH, Evers BM
Cancer Res. 2007
PubMed ID: 17699782
-
Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma.
Ollikainen M, Gylling A, Puputti M, Nupponen NN, Abdel-Rahman WM, Butzow R, Peltomäki P
Int J Cancer. 2007
PubMed ID: 17471559
-
Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain.
Odriozola L, Singh G, Hoang T, Chan AM
J Biol Chem. 2007
PubMed ID: 17565999
-
BMP suppresses PTEN expression via RAS/ERK signaling.
Beck SE, Carethers JM
Cancer Biol Ther. 2007
PubMed ID: 18059158
-
[Expressions of phosphorylated-Smad2 and PTEN in hepatocellular carcinomas and adjacent liver tissues]
Wu SK, Wang BJ, Yang Y, Tian YJ, Bao JJ, Feng XH, Yang DL
Zhonghua Gan Zang Bing Za Zhi. 2007
PubMed ID: 17711623
-
Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults.
Rajaraman P, Wang SS, Rothman N, Brown MM, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Chanock SJ, Inskip PD
Cancer Epidemiol Biomarkers Prev. 2007
PubMed ID: 17684142
-
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer.
Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T
Gastroenterology. 2007
PubMed ID: 17681183
-
Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence.
Liao CP, Zhong C, Saribekyan G, Bading J, Park R, Conti PS, Moats R, Berns A, Shi W, Zhou Z, Nikitin AY, Roy-Burman P
Cancer Res. 2007
PubMed ID: 17671224
-
Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney.
Little SE, Bax DA, Rodriguez-Pinilla M, Natrajan R, Messahel B, Pritchard-Jones K, Vujanic GM, Reis-Filho JS, Jones C
Clin Cancer Res. 2007
PubMed ID: 17646270
-
Phosphoinositide 3-kinases as a common platform for multi-hormone signaling.
Hirsch E, Costa C, Ciraolo E
J Endocrinol. 2007
PubMed ID: 17641274
-
Variants in EMX2 and PTEN do not contribute to risk of endometriosis.
Treloar SA, Zhao ZZ, Le L, Zondervan KT, Martin NG, Kennedy S, Nyholt DR, Montgomery GW
Mol Hum Reprod. 2007
PubMed ID: 17563403
-
Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth.
Ford-Hutchinson AF, Ali Z, Lines SE, Hallgrímsson B, Boyd SK, Jirik FR
J Bone Miner Res. 2007
PubMed ID: 17456009
-
Up-regulation of PTEN at the transcriptional level is an adverse prognostic factor in female lung adenocarcinomas.
Inamura K, Togashi Y, Nomura K, Ninomiya H, Hiramatsu M, Okui M, Satoh Y, Okumura S, Nakagawa K, Tsuchiya E, Ishikawa Y
Lung Cancer. 2007
PubMed ID: 17452061
-
PTEN is destabilized by phosphorylation on Thr366.
Maccario H, Perera NM, Davidson L, Downes CP, Leslie NR
Biochem J. 2007
PubMed ID: 17444818
-
Phosphorylated galectin-3 mediates tumor necrosis factor-related apoptosis-inducing ligand signaling by regulating phosphatase and tensin homologue deleted on chromosome 10 in human breast carcinoma cells.
Mazurek N, Sun YJ, Liu KF, Gilcrease MZ, Schober W, Nangia-Makker P, Raz A, Bresalier RS
J Biol Chem. 2007
PubMed ID: 17420249
-
Pten inactivation and the emergence of androgen-independent prostate cancer.
Shen MM, Abate-Shen C
Cancer Res. 2007
PubMed ID: 17638861
-
PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney.
Kim D, Dressler GR
Dev Biol. 2007
PubMed ID: 17540362
-
The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN.
Papakonstanti EA, Ridley AJ, Vanhaesebroeck B
EMBO J. 2007
PubMed ID: 17581634
-
[The correlation study of PTEN gene expression and Akt phosphorylation in myelodysplastic syndrome]
Chen BG, Zhu M, Luo WD, Yan WH, Zhou MY, Li BL, Tao DD
Zhonghua Xue Ye Xue Za Zhi. 2007
PubMed ID: 18072631
-
Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha.
Dan HC, Adli M, Baldwin AS
Cancer Res. 2007
PubMed ID: 17616684
-
Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development.
Jiao J, Wang S, Qiao R, Vivanco I, Watson PA, Sawyers CL, Wu H
Cancer Res. 2007
PubMed ID: 17616663
-
Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids.
Berquin IM, Min Y, Wu R, Wu J, Perry D, Cline JM, Thomas MJ, Thornburg T, Kulik G, Smith A, Edwards IJ, D'Agostino R, Zhang H, Wu H, Kang JX, Chen YQ
J Clin Invest. 2007
PubMed ID: 17607361
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Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation.
Bedolla R, Prihoda TJ, Kreisberg JI, Malik SN, Krishnegowda NK, Troyer DA, Ghosh PM
Clin Cancer Res. 2007
PubMed ID: 17606718
-
Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma.
Wiencke JK, Zheng S, Jelluma N, Tihan T, Vandenberg S, Tamgüney T, Baumber R, Parsons R, Lamborn KR, Berger MS, Wrensch MR, Haas-Kogan DA, Stokoe D
Neuro Oncol. 2007
PubMed ID: 17504928
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Consequences of the loss of p53, RB1, and PTEN: relationship to gefitinib resistance in endometrial cancer.
Albitar L, Carter MB, Davies S, Leslie KK
Gynecol Oncol. 2007
PubMed ID: 17490733
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Differential association of phosphatidylinositol 3-kinase, SHIP-1, and PTEN with forming phagosomes.
Kamen LA, Levinsohn J, Swanson JA
Mol Biol Cell. 2007
PubMed ID: 17442886
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Mgat5 and Pten interact to regulate cell growth and polarity.
Cheung P, Dennis JW
Glycobiology. 2007
PubMed ID: 17400585
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Segmental overgrowth, lipomatosis, arteriovenous malformation and epidermal nevus (SOLAMEN) syndrome is related to mosaic PTEN nullizygosity.
Caux F, Plauchu H, Chibon F, Faivre L, Fain O, Vabres P, Bonnet F, Selma ZB, Laroche L, Gérard M, Longy M
Eur J Hum Genet. 2007
PubMed ID: 17392703
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The role of PTEN in prostate cancer cell tropism to the bone micro-environment.
Wu Z, McRoberts KS, Theodorescu D
Carcinogenesis. 2007
PubMed ID: 17347137
-
PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation.
Xiao Y, Yeong Chit Chia J, Gajewski JE, Sio Seng Lio D, Mulhern TD, Zhu HJ, Nandurkar H, Cheng HC
Cell Signal. 2007
PubMed ID: 17324556
-
Inhibition of PTEN by peroxynitrite activates the phosphoinositide-3-kinase/Akt neuroprotective signaling pathway.
Delgado-Esteban M, Martin-Zanca D, Andres-Martin L, Almeida A, Bolaños JP
J Neurochem. 2007
PubMed ID: 17302912
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PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer.
Pérez-Tenorio G, Alkhori L, Olsson B, Waltersson MA, Nordenskjöld B, Rutqvist LE, Skoog L, Stål O
Clin Cancer Res. 2007
PubMed ID: 17575221
-
Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly.
Buxbaum JD, Cai G, Chaste P, Nygren G, Goldsmith J, Reichert J, Anckarsäter H, Rastam M, Smith CJ, Silverman JM, Hollander E, Leboyer M, Gillberg C, Verloes A, Betancur C
Am J Med Genet B Neuropsychiatr Genet. 2007
PubMed ID: 17427195
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[Regulation of tissue factor expression by anti-oncogene PTEN in human neuroblastoma cell line]
Fang J, Tang H, Xia LH, Wei WN, Hu Y, Song SJ
Zhonghua Xue Ye Xue Za Zhi. 2007
PubMed ID: 17939398
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Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice.
Watanabe S, Horie Y, Kataoka E, Sato W, Dohmen T, Ohshima S, Goto T, Suzuki A
J Gastroenterol Hepatol. 2007
PubMed ID: 17567478
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The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas.
Hernando E, Charytonowicz E, Dudas ME, Menendez S, Matushansky I, Mills J, Socci ND, Behrendt N, Ma L, Maki RG, Pandolfi PP, Cordon-Cardo C
Nat Med. 2007
PubMed ID: 17496901
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PTEN reduces cuff-induced neointima formation and proinflammatory cytokines.
Koide S, Okazaki M, Tamura M, Ozumi K, Takatsu H, Kamezaki F, Tanimoto A, Tasaki H, Sasaguri Y, Nakashima Y, Otsuji Y
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17277022
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PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway.
Koul D, Shen R, Shishodia S, Takada Y, Bhat KP, Reddy SA, Aggarwal BB, Yung WK
Mol Cell Biochem. 2007
PubMed ID: 17235455
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Molecular genetic defects in endometrial carcinomas: microsatellite instability, PTEN and beta-catenin (CTNNB1) genes mutations.
Konopka B, Janiec-Jankowska A, Czapczak D, Paszko Z, Bidziński M, Olszewski W, Goluda C
J Cancer Res Clin Oncol. 2007
PubMed ID: 17219201
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PTEN regulates phospholipase D and phospholipase C.
Alvarez-Breckenridge CA, Waite KA, Eng C
Hum Mol Genet. 2007
PubMed ID: 17405772
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[Biological implication of PTEN gene expression in human gastric cancer and related molecular mechanisms]
He RF, Hu ZL, Wen JF
Zhonghua Bing Li Xue Za Zhi. 2007
PubMed ID: 17706140
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[Expression and significance of P16INK4A and PTEN in high-risk human papillomavirus-related cervical cancer]
Zhao XL, Cheng SX, Kong XD
Ai Zheng. 2007
PubMed ID: 17672936
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The prognostic value of PTEN, p53, and beta-catenin in endometrial carcinoma: a prospective immunocytochemical study.
Athanassiadou P, Athanassiades P, Grapsa D, Gonidi M, Athanassiadou AM, Stamati PN, Patsouris E
Int J Gynecol Cancer. 2007
PubMed ID: 17504383
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Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.
Saal LH, Johansson P, Holm K, Gruvberger-Saal SK, She QB, Maurer M, Koujak S, Ferrando AA, Malmström P, Memeo L, Isola J, Bendahl PO, Rosen N, Hibshoosh H, Ringnér M, Borg A, Parsons R
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17452630
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Recurrent 10q22-q23 deletions: a genomic disorder on 10q associated with cognitive and behavioral abnormalities.
Balciuniene J, Feng N, Iyadurai K, Hirsch B, Charnas L, Bill BR, Easterday MC, Staaf J, Oseth L, Czapansky-Beilman D, Avramopoulos D, Thomas GH, Borg A, Valle D, Schimmenti LA, Selleck SB
Am J Hum Genet. 2007
PubMed ID: 17436248
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Correlation of chromosomal imbalances by comparative genomic hybridization and expression of EGFR, PTEN, p53, and MIB-1 in diffuse gliomas.
Yakut T, Gutenberg A, Bekar A, Egeli U, Gunawan B, Ercan I, Tolunay S, Doygun M, Schulten HJ
Oncol Rep. 2007
PubMed ID: 17390041
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Comparative genomic and functional analyses reveal a novel cis-acting PTEN regulatory element as a highly conserved functional E-box motif deleted in Cowden syndrome.
Pezzolesi MG, Zbuk KM, Waite KA, Eng C
Hum Mol Genet. 2007
PubMed ID: 17341483
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Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions.
Subramanian KK, Jia Y, Zhu D, Simms BT, Jo H, Hattori H, You J, Mizgerd JP, Luo HR
Blood. 2007
PubMed ID: 17202315
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In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis.
Su Y, Eason RR, Geng Y, Till SR, Badger TM, Simmen RC
Carcinogenesis. 2007
PubMed ID: 17166883
-
Impact of novel PTEN mutations in Turkish patients with glioblastoma multiforme.
Tunca B, Bekar A, Cecener G, Egeli U, Vatan O, Tolunay S, Kocaeli H, Aksoy K
J Neurooncol. 2007
PubMed ID: 17151929
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Regulation of SCF(SKP2) ubiquitin E3 ligase assembly and p27(KIP1) proteolysis by the PTEN pathway and cyclin D1.
Jonason JH, Gavrilova N, Wu M, Zhang H, Sun H
Cell Cycle. 2007
PubMed ID: 17438373
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Phosphorylation of the survival kinase Akt by superoxide is dependent on an ascorbate-reversible oxidation of PTEN.
Lim S, Clément MV
Free Radic Biol Med. 2007
PubMed ID: 17382199
-
The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells.
Kishimoto H, Ohteki T, Yajima N, Kawahara K, Natsui M, Kawarasaki S, Hamada K, Horie Y, Kubo Y, Arase S, Taniguchi M, Vanhaesebroeck B, Mak TW, Nakano T, Koyasu S, Sasaki T, Suzuki A
Blood. 2007
PubMed ID: 17170126
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GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN.
Huang W, Chang HY, Fei T, Wu H, Chen YG
Oncogene. 2007
PubMed ID: 17043650
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A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.
Murcia CL, Gulden FO, Cherosky NA, Herrup K
Brain Res. 2007
PubMed ID: 16884697
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Peroxisome proliferator-activated receptor gamma and retinoic acid receptor synergistically up-regulate the tumor suppressor PTEN in human promyeloid leukemia cells.
Lee YR, Yu HN, Noh EM, Kim JS, Song EK, Han MK, Kim BS, Lee SH, Park J
Int J Hematol. 2007
PubMed ID: 17483060
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Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways.
Wu R, Hendrix-Lucas N, Kuick R, Zhai Y, Schwartz DR, Akyol A, Hanash S, Misek DE, Katabuchi H, Williams BO, Fearon ER, Cho KR
Cancer Cell. 2007
PubMed ID: 17418409
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Immunohistochemical expression of PTEN and beta-catenin for endometrial intraepithelial neoplasia in Japanese women.
Norimatsu Y, Moriya T, Kobayashi TK, Sakurai T, Shimizu K, Tsukayama C, Ohno E
Ann Diagn Pathol. 2007
PubMed ID: 17349568
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Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer.
Mehrian-Shai R, Chen CD, Shi T, Horvath S, Nelson SF, Reichardt JK, Sawyers CL
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17372210
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Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis.
Schmitz M, Grignard G, Margue C, Dippel W, Capesius C, Mossong J, Nathan M, Giacchi S, Scheiden R, Kieffer N
Int J Cancer. 2007
PubMed ID: 17163422
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Role of tumor suppressor PTEN in tumor necrosis factor alpha-induced inhibition of insulin signaling in murine skeletal muscle C2C12 cells.
Lo YT, Tzeng TF, Liu IM
Horm Metab Res. 2007
PubMed ID: 17373630
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Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model.
Milam MR, Celestino J, Wu W, Broaddus RR, Schmeler KM, Slomovitz BM, Soliman PT, Gershenson DM, Wang H, Ellenson LH, Lu KH
Am J Obstet Gynecol. 2007
PubMed ID: 17346540
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A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
Flores-Delgado G, Liu CW, Sposto R, Berndt N
J Proteome Res. 2007
PubMed ID: 17274640
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Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella.
Nayeem N, Kerr F, Naumann H, Linehan J, Lovestone S, Brandner S
Mol Cell Neurosci. 2007
PubMed ID: 17208451
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Mouse bone marrow and peripheral blood erythroid cell counts are regulated by different autosomal genetic loci.
Jawad M, Giotopoulos G, Fitch S, Cole C, Plumb M, Talbot CJ
Blood Cells Mol Dis. 2007
PubMed ID: 17185011
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Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone receptor expression in breast carcinoma.
Tokunaga E, Oki E, Kimura Y, Yamanaka T, Egashira A, Nishida K, Koga T, Morita M, Kakeji Y, Maehara Y
Breast Cancer Res Treat. 2007
PubMed ID: 17006756
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TNF-alpha upregulates PTEN via NF-kappaB signaling pathways in human leukemic cells.
Lee YR, Yu HN, Noh EM, Youn HJ, Song EK, Han MK, Park CS, Kim BS, Park YS, Park BK, Lee SH, Kim JS
Exp Mol Med. 2007
PubMed ID: 17334236
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Lifelong accumulation of bone in mice lacking Pten in osteoblasts.
Liu X, Bruxvoort KJ, Zylstra CR, Liu J, Cichowski R, Faugere MC, Bouxsein ML, Wan C, Williams BO, Clemens TL
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17287359
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Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.
Chugh P, Fan S, Planelles V, Maggirwar SB, Dewhurst S, Kim B
J Mol Biol. 2007
PubMed ID: 17157319
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Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury.
Zhang QG, Wu DN, Han D, Zhang GY
FEBS Lett. 2007
PubMed ID: 17239858
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ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages.
Cruz CM, Rinna A, Forman HJ, Ventura AL, Persechini PM, Ojcius DM
J Biol Chem. 2007
PubMed ID: 17132626
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[Clinical significance and expression of FLIP and PTEN protein in laryngeal squamous cell carcinoma].
Wei Z, Jiang X, Zhou X
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007
PubMed ID: 17441421
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Exogenous PTEN gene induces apoptosis in breast carcinoma cell line MDA468.
Chen Q, Wang C, Jiang C, Chen D
J Huazhong Univ Sci Technolog Med Sci. 2007
PubMed ID: 17393112
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Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis.
Yeager N, Klein-Szanto A, Kimura S, Di Cristofano A
Cancer Res. 2007
PubMed ID: 17283127
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PTEN-deficient intestinal stem cells initiate intestinal polyposis.
He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L
Nat Genet. 2007
PubMed ID: 17237784
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The p85alpha regulatory subunit of class IA phosphoinositide 3-kinase regulates beta-selection in thymocyte development.
Shiroki F, Matsuda S, Doi T, Fujiwara M, Mochizuki Y, Kadowaki T, Suzuki H, Koyasu S
J Immunol. 2007
PubMed ID: 17237381
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Phosphorylation of PTEN (phosphatase and tensin homologue deleted on chromosome ten) protein is enhanced in human fibromyomatous uteri.
Kovács KA, Lengyel F, Vértes Z, Környei JL, Gocze PM, Sumegi B, Szabó I, Vértes M
J Steroid Biochem Mol Biol. 2007
PubMed ID: 17097286
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Expression of PTEN and Akt phosphorylation in lipopolysaccharide-treated NIH3T3 cells.
Okamura H, Yoshida K, Sasaki E, Qiu L, Amorim BR, Morimoto H, Haneji T
Cell Biol Int. 2007
PubMed ID: 17081778
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c-Jun promotes cellular survival by suppression of PTEN.
Hettinger K, Vikhanskaya F, Poh MK, Lee MK, de Belle I, Zhang JT, Reddy SA, Sabapathy K
Cell Death Differ. 2007
PubMed ID: 16676006
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Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
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PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors.
Mellinghoff IK, Cloughesy TF, Mischel PS
Clin Cancer Res. 2007
PubMed ID: 17255257
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Essential role for nuclear PTEN in maintaining chromosomal integrity.
Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, Yin Y
Cell. 2007
PubMed ID: 17218262
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Ubiquitination regulates PTEN nuclear import and tumor suppression.
Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H, Pavletich NP, Carver BS, Cordon-Cardo C, Erdjument-Bromage H, Tempst P, Chi SG, Kim HJ, Misteli T, Jiang X, Pandolfi PP
Cell. 2007
PubMed ID: 17218261
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NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.
Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X
Cell. 2007
PubMed ID: 17218260
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A novel model to identify interaction partners of the PTEN tumor suppressor gene in human bladder cancer.
Herlevsen M, Oxford G, Ptak C, Shabanowitz J, Hunt DF, Conaway M, Theodorescu D
Biochem Biophys Res Commun. 2007
PubMed ID: 17126809
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Tumor spectrum, tumor latency and tumor incidence of the Pten-deficient mice.
Lu TL, Chang JL, Liang CC, You LR, Chen CM
PLoS ONE. 2007
PubMed ID: 18043744
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Prognostic significance of PTEN expression in esophageal squamous cell carcinoma from Linzhou City, a high incidence area of northern China.
Chang D, Wang TY, Li HC, Wei JC, Song JX
Dis Esophagus. 2007
PubMed ID: 17958724
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PTEN and NDUFB8 aberrations in cervical cancer tissue.
Hsieh SM, Maguire DJ, Lintell NA, McCabe M, Griffiths LR
Adv Exp Med Biol. 2007
PubMed ID: 17727244
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MMAC tumor supressor gene expression in ovarian endometriosis and ovarian adenocarcinoma.
Cirpan T, Aygul S, Terek MC, Kazandi M, Dikmen Y, Zekioglu O, Sagol S
Eur J Gynaecol Oncol. 2007
PubMed ID: 17713092
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Role of PTEN gene in progression of prostate cancer.
Pourmand G, Ziaee AA, Abedi AR, Mehrsai A, Alavi HA, Ahmadi A, Saadati HR
Urol J. 2007
PubMed ID: 17701929
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Germline mutations in the breast cancer susceptibility gene PTEN are rare in high-risk non-BRCA1/2 French Canadian breast cancer families.
Guénard F, Labrie Y, Ouellette G, Beauparlant CJ, Bessette P, Chiquette J, Laframboise R, Lépine J, Lespérance B, Pichette R, Plante M, Durocher F, INHERIT BRCAs
Fam Cancer. 2007
PubMed ID: 17636424
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Expression of PTEN and FHIT is involved in regulating the balance between apoptosis and proliferation in lung carcinomas.
Zheng H, Tsuneyama K, Takahashi H, Miwa S, Nomoto K, Saito H, Masuda S, Takano Y
Anticancer Res. 2007
PubMed ID: 17348444
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Immunohistochemical expression of PTEN in normal, hyperplastic and malignant endometrium and its correlation with hormone receptors, bcl-2, bax, and apoptotic index.
Kapucuoglu N, Aktepe F, Kaya H, Bircan S, Karahan N, Ciriş M
Pathol Res Pract. 2007
PubMed ID: 17317031
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Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance.
Lin PY, Fosmire SP, Park SH, Park JY, Baksh S, Modiano JF, Weiss RH
Mol Cancer. 2007
PubMed ID: 17300726
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Epigenetic interactions and the structure of phenotypic variation in the cranium.
Hallgrímsson B, Lieberman DE, Liu W, Ford-Hutchinson AF, Jirik FR
Evol Dev. 2007
PubMed ID: 17227368
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Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1.
Nishio M, Watanabe K, Sasaki J, Taya C, Takasuga S, Iizuka R, Balla T, Yamazaki M, Watanabe H, Itoh R, Kuroda S, Horie Y, Förster I, Mak TW, Yonekawa H, Penninger JM, Kanaho Y, Suzuki A, Sasaki T
Nat Cell Biol. 2007
PubMed ID: 17173042
-
Overexpression of PTEN suppresses growth and induces apoptosis by inhibiting the expression of survivin in bladder cancer cells.
Wu ZX, Song TB, Li DM, Zhang XT, Wu XL
Tumour Biol. 2007
PubMed ID: 17108713
-
Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.
Kim JS, Lee C, Bonifant CL, Ressom H, Waldman T
Mol Cell Biol. 2007
PubMed ID: 17060456
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Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines.
Sharrard RM, Maitland NJ
Cell Signal. 2007
PubMed ID: 16842970
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Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein.
Minaguchi T, Waite KA, Eng C
Cancer Res. 2006
PubMed ID: 17178862
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Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.
Lindsay Y, McCoull D, Davidson L, Leslie NR, Fairservice A, Gray A, Lucocq J, Downes CP
J Cell Sci. 2006
PubMed ID: 17158918
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[Expression and clinical significance of survivin gene and PTEN gene in laryngeal squamous cell carcinomas].
Zhu L, Wang S
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006
PubMed ID: 17357516
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[Expression of two kinds of tumor correlation protein in laryngeal carcinoma and precancerous lesions].
Zhao HC, He XG
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2006
PubMed ID: 17345711
-
Decreased hepatic futile cycling compensates for increased glucose disposal in the Pten heterodeficient mouse.
Xu J, Gowen L, Raphalides C, Hoyer KK, Weinger JG, Renard M, Troke JJ, Vaitheesyaran B, Lee WN, Saad MF, Sleeman MW, Teitell MA, Kurland IJ
Diabetes. 2006
PubMed ID: 17130482
-
PTEN c.511C>T nonsense mutation in a BRRS family disrupts a potential exonic splicing enhancer and causes exon skipping.
Suphapeetiporn K, Kongkam P, Tantivatana J, Sinthuwiwat T, Tongkobpetch S, Shotelersuk V
Jpn J Clin Oncol. 2006
PubMed ID: 17043057
-
Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasias.
Schick V, Majores M, Engels G, Spitoni S, Koch A, Elger CE, Simon M, Knobbe C, Blümcke I, Becker AJ
Acta Neuropathol. 2006
PubMed ID: 17013611
-
Ultraviolet B-induced matrix metalloproteinase-1 and -3 secretions are mediated via PTEN/Akt pathway in human dermal fibroblasts.
Oh JH, Kim A, Park JM, Kim SH, Chung AS
J Cell Physiol. 2006
PubMed ID: 16972255
-
PTEN modulates hepatitis B virus-X protein induced survival signaling in Chang liver cells.
Kang-Park S, Im JH, Lee JH, Lee YI
Virus Res. 2006
PubMed ID: 16872708
-
PTEN regulates fibroblast elimination during collagen matrix contraction.
Nho RS, Xia H, Diebold D, Kahm J, Kleidon J, White E, Henke CA
J Biol Chem. 2006
PubMed ID: 16963781
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Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort.
Pollack IF, Hamilton RL, James CD, Finkelstein SD, Burnham J, Yates AJ, Holmes EJ, Zhou T, Finlay JL, Children's Oncology Group
J Neurosurg. 2006
PubMed ID: 17328268
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[Expression of epidermal growth factor receptor and PTEN in malignancy brain tumors]
Liu JG, Liu YH, Cai J, Liu XS, Song WZ, Huang Y, Mao Q
Sichuan Da Xue Xue Bao Yi Xue Ban. 2006
PubMed ID: 17236582
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[Contiguous gene deletion within chromosome arm 10q is associated with juvenile polyposis of infancy, reflecting cooperation between the BMPR1A and PTEN tumor-suppressor genes]
Delnatte C, Sanlaville D, Mougenot JF, Stoppa-Lyonnet D
Med Sci (Paris). 2006
PubMed ID: 17101085
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Mutation-positive and mutation-negative patients with Cowden and Bannayan-Riley-Ruvalcaba syndromes associated with distinct 10q haplotypes.
Pezzolesi MG, Li Y, Zhou XP, Pilarski R, Shen L, Eng C
Am J Hum Genet. 2006
PubMed ID: 17033968
-
PTEN in the haematopoietic system and its therapeutic indications.
Cheung AM, Mak TW
Trends Mol Med. 2006
PubMed ID: 16996801
-
PIK3CA gene mutations in endometrial carcinoma: correlation with PTEN and K-RAS alterations.
Velasco A, Bussaglia E, Pallares J, Dolcet X, Llobet D, Encinas M, Llecha N, Palacios J, Prat J, Matias-Guiu X
Hum Pathol. 2006
PubMed ID: 16949921
-
PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations.
Kolasa IK, Rembiszewska A, Janiec-Jankowska A, Dansonka-Mieszkowska A, Lewandowska AM, Konopka B, Kupryjańczyk J
Gynecol Oncol. 2006
PubMed ID: 16793127
-
PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia.
Hayes MP, Wang H, Espinal-Witter R, Douglas W, Solomon GJ, Baker SJ, Ellenson LH
Clin Cancer Res. 2006
PubMed ID: 17062663
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Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death.
Zhu D, Hattori H, Jo H, Jia Y, Subramanian KK, Loison F, You J, Le Y, Honczarenko M, Silberstein L, Luo HR
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16988010
-
Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling.
Omori SA, Cato MH, Anzelon-Mills A, Puri KD, Shapiro-Shelef M, Calame K, Rickert RC
Immunity. 2006
PubMed ID: 17000121
-
Combination of PTEN gene therapy and radiation inhibits the growth of human prostate cancer xenografts.
Anai S, Goodison S, Shiverick K, Iczkowski K, Tanaka M, Rosser CJ
Hum Gene Ther. 2006
PubMed ID: 16984224
-
Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN.
Buckler JL, Walsh PT, Porrett PM, Choi Y, Turka LA
J Immunol. 2006
PubMed ID: 16982858
-
Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer.
Gao H, Ouyang X, Banach-Petrosky WA, Gerald WL, Shen MM, Abate-Shen C
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16973750
-
PCAF modulates PTEN activity.
Okumura K, Mendoza M, Bachoo RM, DePinho RA, Cavenee WK, Furnari FB
J Biol Chem. 2006
PubMed ID: 16829519
-
Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways.
Park CM, Park MJ, Kwak HJ, Lee HC, Kim MS, Lee SH, Park IC, Rhee CH, Hong SI
Cancer Res. 2006
PubMed ID: 16951163
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Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients.
Tsuruta H, Kishimoto H, Sasaki T, Horie Y, Natsui M, Shibata Y, Hamada K, Yajima N, Kawahara K, Sasaki M, Tsuchiya N, Enomoto K, Mak TW, Nakano T, Habuchi T, Suzuki A
Cancer Res. 2006
PubMed ID: 16951148
-
Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias.
Yoshimoto M, Cutz JC, Nuin PA, Joshua AM, Bayani J, Evans AJ, Zielenska M, Squire JA
Cancer Genet Cytogenet. 2006
PubMed ID: 16938570
-
PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs.
Walsh PT, Buckler JL, Zhang J, Gelman AE, Dalton NM, Taylor DK, Bensinger SJ, Hancock WW, Turka LA
J Clin Invest. 2006
PubMed ID: 16917540
-
Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation.
Park C, Lavine K, Mishina Y, Deng CX, Ornitz DM, Choi K
Development. 2006
PubMed ID: 16887829
-
The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulation.
Chung JH, Ostrowski MC, Romigh T, Minaguchi T, Waite KA, Eng C
Hum Mol Genet. 2006
PubMed ID: 16849370
-
Suppression of PTEN expression during aggregation with retinoic acid in P19 mouse embryonal carcinoma cells.
Lee JH, Shin SY, Kim S, Choo J, Lee YH
Biochem Biophys Res Commun. 2006
PubMed ID: 16842746
-
PTEN inhibits adrenomedullin expression and function in brain tumor cells.
Betchen SA, Musatov S, Roberts J, Pena J, Kaplitt MG
J Neurooncol. 2006
PubMed ID: 16821090
-
Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs.
Gil A, Andrés-Pons A, Fernández E, Valiente M, Torres J, Cervera J, Pulido R
Mol Biol Cell. 2006
PubMed ID: 16807353
-
Osteopontin is a downstream effector of the PI3-kinase pathway in melanomas that is inversely correlated with functional PTEN.
Packer L, Pavey S, Parker A, Stark M, Johansson P, Clarke B, Pollock P, Ringner M, Hayward N
Carcinogenesis. 2006
PubMed ID: 16571650
-
Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse.
Dai B, Kim O, Xie Y, Guo Z, Xu K, Wang B, Kong X, Melamed J, Chen H, Bieberich CJ, Borowsky AD, Kung HJ, Wei G, Ostrowski MC, Brodie A, Qiu Y
Cancer Res. 2006
PubMed ID: 16912182
-
Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice.
Gao H, Ouyang X, Banach-Petrosky WA, Shen MM, Abate-Shen C
Cancer Res. 2006
PubMed ID: 16912166
-
Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells.
Wang MY, Lu KV, Zhu S, Dia EQ, Vivanco I, Shackleford GM, Cavenee WK, Mellinghoff IK, Cloughesy TF, Sawyers CL, Mischel PS
Cancer Res. 2006
PubMed ID: 16912159
-
Down-regulation of PTEN by sodium orthovanadate inhibits ASK1 activation via PI3-K/Akt during cerebral ischemia in rat hippocampus.
Wu DN, Pei DS, Wang Q, Zhang GY
Neurosci Lett. 2006
PubMed ID: 16762504
-
Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.
Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, Kahn CR
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16880400
-
Analysis of PTEN mutation in non-familial pheochromocytoma.
Puc J, Placha G, Wocial B, Podsypanina K, Parsons R, Gaciong Z
Ann N Y Acad Sci. 2006
PubMed ID: 17102102
-
Mechanistic insights into maintenance of high p53 acetylation by PTEN.
Li AG, Piluso LG, Cai X, Wei G, Sellers WR, Liu X
Mol Cell. 2006
PubMed ID: 16916644
-
Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo.
Wendel HG, Malina A, Zhao Z, Zender L, Kogan SC, Cordon-Cardo C, Pelletier J, Lowe SW
Cancer Res. 2006
PubMed ID: 16885364
-
High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model.
Wei Q, Clarke L, Scheidenhelm DK, Qian B, Tong A, Sabha N, Karim Z, Bock NA, Reti R, Swoboda R, Purev E, Lavoie JF, Bajenaru ML, Shannon P, Herlyn D, Kaplan D, Henkelman RM, Gutmann DH, Guha A
Cancer Res. 2006
PubMed ID: 16885338
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
Engelman JA, Luo J, Cantley LC
Nat Rev Genet. 2006
PubMed ID: 16847462
-
Critical role for Daxx in regulating Mdm2.
Tang J, Qu LK, Zhang J, Wang W, Michaelson JS, Degenhardt YY, El-Deiry WS, Yang X
Nat Cell Biol. 2006
PubMed ID: 16845383
-
Activation of casein kinase II and inhibition of phosphatase and tensin homologue deleted on chromosome 10 phosphatase by nerve growth factor/p75NTR inhibit glycogen synthase kinase-3beta and stimulate axonal growth.
Arevalo MA, Rodríguez-Tébar A
Mol Biol Cell. 2006
PubMed ID: 16723502
-
Gene expression analysis reveals a signature of estrogen receptor activation upon loss of Pten in a mouse model of endometrial cancer.
Lian Z, De Luca P, Di Cristofano A
J Cell Physiol. 2006
PubMed ID: 16688764
-
Expression of mTOR signaling pathway markers in prostate cancer progression.
Kremer CL, Klein RR, Mendelson J, Browne W, Samadzedeh LK, Vanpatten K, Highstrom L, Pestano GA, Nagle RB
Prostate. 2006
PubMed ID: 16652388
-
The relationship between microsatellite instability and PTEN gene mutations in endometrial cancer.
Bilbao C, Rodríguez G, Ramírez R, Falcón O, León L, Chirino R, Rivero JF, Falcón O, Díaz-Chico BN, Díaz-Chico JC, Perucho M
Int J Cancer. 2006
PubMed ID: 16506206
-
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN.
Zhao M, Song B, Pu J, Wada T, Reid B, Tai G, Wang F, Guo A, Walczysko P, Gu Y, Sasaki T, Suzuki A, Forrester JV, Bourne HR, Devreotes PN, McCaig CD, Penninger JM
Nature. 2006
PubMed ID: 16871217
-
S6k1 is not required for Pten-deficient neuronal hypertrophy.
Chalhoub N, Kozma SC, Baker SJ
Brain Res. 2006
PubMed ID: 16777079
-
Synergistic function of Smad4 and PTEN in suppressing forestomach squamous cell carcinoma in the mouse.
Teng Y, Sun AN, Pan XC, Yang G, Yang LL, Wang MR, Yang X
Cancer Res. 2006
PubMed ID: 16849541
-
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal.
You H, Pellegrini M, Tsuchihara K, Yamamoto K, Hacker G, Erlacher M, Villunger A, Mak TW
J Exp Med. 2006
PubMed ID: 16801400
-
[Expression of tumor suppressor gene PTEN, PIP3 and cyclin D1 in oral squamous cell carcinoma and their correlations]
Xie SM, Shen LJ, Yin C, Ruan P, Yao X
Zhonghua Kou Qiang Yi Xue Za Zhi. 2006
PubMed ID: 17067457
-
Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction.
Vazquez F, Devreotes P
Cell Cycle. 2006
PubMed ID: 16861931
-
Epigenetic silencing of the PTEN gene in melanoma.
Mirmohammadsadegh A, Marini A, Nambiar S, Hassan M, Tannapfel A, Ruzicka T, Hengge UR
Cancer Res. 2006
PubMed ID: 16818626
-
Genetic background controls tumor development in PTEN-deficient mice.
Freeman D, Lesche R, Kertesz N, Wang S, Li G, Gao J, Groszer M, Martinez-Diaz H, Rozengurt N, Thomas G, Liu X, Wu H
Cancer Res. 2006
PubMed ID: 16818619
-
Patterns of loss of heterozygosity at 10q23.3 and microsatellite instability in endometriosis, atypical endometriosis, and ovarian carcinoma arising in association with endometriosis.
Ali-Fehmi R, Khalifeh I, Bandyopadhyay S, Lawrence WD, Silva E, Liao D, Sarkar FH, Munkarah AR
Int J Gynecol Pathol. 2006
PubMed ID: 16810057
-
Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN.
Mahimainathan L, Das F, Venkatesan B, Choudhury GG
Diabetes. 2006
PubMed ID: 16804083
-
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.
Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC
J Clin Invest. 2006
PubMed ID: 16794735
-
Distinct expression profiles for PTEN transcript and its splice variants in Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome.
Sarquis MS, Agrawal S, Shen L, Pilarski R, Zhou XP, Eng C
Am J Hum Genet. 2006
PubMed ID: 16773562
-
Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.
Xu X, Kobayashi S, Qiao W, Li C, Xiao C, Radaeva S, Stiles B, Wang RH, Ohara N, Yoshino T, LeRoith D, Torbenson MS, Gores GJ, Wu H, Gao B, Deng CX
J Clin Invest. 2006
PubMed ID: 16767220
-
A germline PTEN mutation with manifestations of prenatal onset and verrucous epidermal nevus.
Tekin M, Hişmi BO, Fitoz S, Yalçinkaya F, Ekim M, Kansu A, Ertem M, Deda G, Tutar E, Arsan S, Zhou XP, Pilarski R, Eng C, Akar N
Am J Med Genet A. 2006
PubMed ID: 16752378
-
Conditional expression of PTEN alters the androgen responsiveness of prostate cancer cells.
Wu Z, Conaway M, Gioeli D, Weber MJ, Theodorescu D
Prostate. 2006
PubMed ID: 16637073
-
Mutation screening and association study of the candidate prostate cancer susceptibility genes MSR1, PTEN, and KLF6.
Bar-Shira A, Matarasso N, Rosner S, Bercovich D, Matzkin H, Orr-Urtreger A
Prostate. 2006
PubMed ID: 16598737
-
Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease.
Hamilton G, Samedi F, Knight J, Archer N, Foy C, Walter S, Turic D, Jehu L, Moore P, Hollingworth P, O'Donovan MC, Williams J, Owen MJ, Lovestone S, Powell JF
Neurosci Lett. 2006
PubMed ID: 16574322
-
The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice.
Chen ML, Xu PZ, Peng XD, Chen WS, Guzman G, Yang X, Di Cristofano A, Pandolfi PP, Hay N
Genes Dev. 2006
PubMed ID: 16778075
-
Loss of PTEN is associated with progression to androgen independence.
Bertram J, Peacock JW, Fazli L, Mui AL, Chung SW, Cox ME, Monia B, Gleave ME, Ong CJ
Prostate. 2006
PubMed ID: 16496415
-
p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control.
Bai F, Pei XH, Pandolfi PP, Xiong Y
Mol Cell Biol. 2006
PubMed ID: 16738322
-
Identification of a tumour suppressor network opposing nuclear Akt function.
Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP
Nature. 2006
PubMed ID: 16680151
-
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention.
Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, Haug JS, Rupp D, Porter-Westpfahl KS, Wiedemann LM, Wu H, Li L
Nature. 2006
PubMed ID: 16633340
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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells.
Yilmaz OH, Valdez R, Theisen BK, Guo W, Ferguson DO, Wu H, Morrison SJ
Nature. 2006
PubMed ID: 16598206
-
Phosphatidylinositol 3'-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN.
Hartmann W, Digon-Söntgerath B, Koch A, Waha A, Endl E, Dani I, Denkhaus D, Goodyer CG, Sörensen N, Wiestler OD, Pietsch T
Clin Cancer Res. 2006
PubMed ID: 16707597
-
PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinib.
Ueda S, Basaki Y, Yoshie M, Ogawa K, Sakisaka S, Kuwano M, Ono M
Cancer Res. 2006
PubMed ID: 16707461
-
Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1.
Zhang CL, Zou Y, Yu RT, Gage FH, Evans RM
Genes Dev. 2006
PubMed ID: 16702404
-
In vivo magnetic resonance volumetric and spectroscopic analysis of mouse prostate cancer models.
Fricke ST, Rodriguez O, Vanmeter J, Dettin LE, Casimiro M, Chien CD, Newell T, Johnson K, Ileva L, Ojeifo J, Johnson MD, Albanese C
Prostate. 2006
PubMed ID: 16425198
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Pten regulates neuronal arborization and social interaction in mice.
Kwon CH, Luikart BW, Powell CM, Zhou J, Matheny SA, Zhang W, Li Y, Baker SJ, Parada LF
Neuron. 2006
PubMed ID: 16675393
-
[Expression of tumor suppressor gene PTEN in laryngeal carcinoma and its clinical significance].
Chen J, Li X
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006
PubMed ID: 16883792
-
Impact of loss of heterozygosity of encoding phosphate and tensin homolog on the prognosis of gastric cancer.
Oki E, Kakeji Y, Baba H, Tokunaga E, Nakamura T, Ueda N, Futatsugi M, Yamamoto M, Ikebe M, Maehara Y
J Gastroenterol Hepatol. 2006
PubMed ID: 16704528
-
Common genetic variation at PTEN and risk of sporadic breast and prostate cancer.
Haiman CA, Stram DO, Cheng I, Giorgi EE, Pooler L, Penney K, Le Marchand L, Henderson BE, Freedman ML
Cancer Epidemiol Biomarkers Prev. 2006
PubMed ID: 16702386
-
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans.
Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ, Di Vizio D, Divicio D, Nogueira C, Stommel J, Pinkus GS, Fletcher C, Hornick JL, Cavenee WK, Furnari FB, Depinho RA
Cancer Cell. 2006
PubMed ID: 16697958
-
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.
Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, Gleave ME, Witte ON, Liu X, Wu H
Cancer Cell. 2006
PubMed ID: 16697957
-
Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival.
Furumoto Y, Brooks S, Olivera A, Takagi Y, Miyagishi M, Taira K, Casellas R, Beaven MA, Gilfillan AM, Rivera J
J Immunol. 2006
PubMed ID: 16621980
-
PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin.
Li G, Hu Y, Huo Y, Liu M, Freeman D, Gao J, Liu X, Wu DC, Wu H
J Biol Chem. 2006
PubMed ID: 16507572
-
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
-
Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice.
Vilgelm A, Lian Z, Wang H, Beauparlant SL, Klein-Szanto A, Ellenson LH, Di Cristofano A
Cancer Res. 2006
PubMed ID: 16585156
-
Alteration and clinical relevance of PTEN expression and its correlation with survivin expression in epithelial ovarian tumors.
Sui L, Dong Y, Watanabe Y, Yamaguchi F, Sugimoto K, Tokuda M
Oncol Rep. 2006
PubMed ID: 16525657
-
Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cel
Shen YH, Zhang L, Gan Y, Wang X, Wang J, LeMaire SA, Coselli JS, Wang XL
J Biol Chem. 2006
PubMed ID: 16418168
-
Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane.
Vazquez F, Matsuoka S, Sellers WR, Yanagida T, Ueda M, Devreotes PN
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16537447
-
[The relationship between hypermethylation of the PTEN promoter and laryngeal squamous cell carcinoma].
Bai W, Li W, Chen X, Wang T
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006
PubMed ID: 16739377
-
[Pathogenic role of PTEN tumor suppressor gene in ovarian cancer associated to endometriosis]
Castiblanco G A, Pires N Y, Wistuba O I, Riquelme S E, Andrade M L, Corvalán R A
Rev Med Chil. 2006
PubMed ID: 16676097
-
Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer.
Daikoku T, Tranguch S, Trofimova IN, Dinulescu DM, Jacks T, Nikitin AY, Connolly DC, Dey SK
Cancer Res. 2006
PubMed ID: 16510568
-
Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse.
Ji SP, Zhang Y, Van Cleemput J, Jiang W, Liao M, Li L, Wan Q, Backstrom JR, Zhang X
Nat Med. 2006
PubMed ID: 16474401
-
Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancer.
Agrawal S, Eng C
Hum Mol Genet. 2006
PubMed ID: 16436456
-
Neonatal estrogenic exposure suppresses PTEN-related endometrial carcinogenesis in recombinant mice.
Begum M, Tashiro H, Katabuchi H, Suzuki A, Kurman RJ, Okamura H
Lab Invest. 2006
PubMed ID: 16402032
-
Casein kinase Iepsilon down-regulates phospho-Akt via PTEN, following genotoxic stress-induced apoptosis in hematopoietic cells.
Okamura A, Iwata N, Tamekane A, Yakushijin K, Nishikawa S, Hamaguchi M, Fukui C, Yamamoto K, Matsui T
Life Sci. 2006
PubMed ID: 16274701
-
The tumor suppressor PTEN is necessary for human Sprouty 2-mediated inhibition of cell proliferation.
Edwin F, Singh R, Endersby R, Baker SJ, Patel TB
J Biol Chem. 2006
PubMed ID: 16371366
-
Human alveolar macrophages are deficient in PTEN. The role of endogenous oxidants.
Flaherty DM, Monick MM, Hinde SL
J Biol Chem. 2006
PubMed ID: 16371363
-
PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling.
Takahashi Y, Morales FC, Kreimann EL, Georgescu MM
EMBO J. 2006
PubMed ID: 16456542
-
Significance of Survivin and PTEN expression in full lymph node-examined gastric cancer.
Deng H, Wu RL, Zhou HY, Huang X, Chen Y, Liu LJ
World J Gastroenterol. 2006
PubMed ID: 16534839
-
Cooperation between FGF8b overexpression and PTEN deficiency in prostate tumorigenesis.
Zhong C, Saribekyan G, Liao CP, Cohen MB, Roy-Burman P
Cancer Res. 2006
PubMed ID: 16489020
-
Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner.
Yoo LI, Liu DW, Le Vu S, Bronson RT, Wu H, Yuan J
Cancer Res. 2006
PubMed ID: 16488991
-
PTEN: a crucial mediator of mitochondria-dependent apoptosis.
Zhu Y, Hoell P, Ahlemeyer B, Krieglstein J
Apoptosis. 2006
PubMed ID: 16502258
-
Deconstructing mammalian reproduction: using knockouts to define fertility pathways.
Roy A, Matzuk MM
Reproduction. 2006
PubMed ID: 16452715
-
PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways.
Yao D, Alexander CL, Quinn JA, Porter MJ, Wu H, Greenhalgh DA
Cancer Res. 2006
PubMed ID: 16452183
-
Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation.
Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16432235
-
Interleukin-18 induces human cardiac endothelial cell death via a novel signaling pathway involving NF-kappaB-dependent PTEN activation.
Chandrasekar B, Valente AJ, Freeman GL, Mahimainathan L, Mummidi S
Biochem Biophys Res Commun. 2006
PubMed ID: 16325763
-
PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer.
Mulholland DJ, Dedhar S, Wu H, Nelson CC
Oncogene. 2006
PubMed ID: 16421604
-
Increased expression of osteopontin contributes to the progression of prostate cancer.
Khodavirdi AC, Song Z, Yang S, Zhong C, Wang S, Wu H, Pritchard C, Nelson PS, Roy-Burman P
Cancer Res. 2006
PubMed ID: 16424021
-
PTEN autoregulates its expression by stabilization of p53 in a phosphatase-independent manner.
Tang Y, Eng C
Cancer Res. 2006
PubMed ID: 16424003
-
Association of the phosphatase and tensin homolog gene (PTEN) with smoking initiation and nicotine dependence.
Zhang L, Kendler KS, Chen X
Am J Med Genet B Neuropsychiatr Genet. 2006
PubMed ID: 16331670
-
PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry.
Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16373498
-
Relationship between PTEN gene expression and differentiation of human glioma.
Yang Y, Shao N, Luo G, Li L, Nilsson-Ehle P, Xu N
Scand J Clin Lab Invest. 2006
PubMed ID: 17000554
-
Diabetes alters vascular mechanotransduction: pressure-induced regulation of mitogen activated protein kinases in the rat inferior vena cava.
Rice KM, Desai DH, Kakarla SK, Katta A, Preston DL, Wehner P, Blough ER
Cardiovasc Diabetol. 2006
PubMed ID: 16961925
-
The PTEN phosphatase is essential for long-term depression of hippocampal synapses.
Wang Y, Cheng A, Mattson MP
Neuromolecular Med. 2006
PubMed ID: 16775384
-
Atheroma development in apolipoprotein E-null mice is not affected by partial inactivation of PTEN.
Andrés V, Gascón-Irún M, Pandolfi PP, González-Navarro H
Front Biosci. 2006
PubMed ID: 16720346
-
PTEN promoter methylation in sporadic thyroid carcinomas.
Alvarez-Nuñez F, Bussaglia E, Mauricio D, Ybarra J, Vilar M, Lerma E, de Leiva A, Matias-Guiu X, Thyroid Neoplasia Study Group
Thyroid. 2006
PubMed ID: 16487009
-
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A
Am J Hum Genet. 2006
PubMed ID: 16385451
-
Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10).
White ES, Atrasz RG, Hu B, Phan SH, Stambolic V, Mak TW, Hogaboam CM, Flaherty KR, Martinez FJ, Kontos CD, Toews GB
Am J Respir Crit Care Med. 2006
PubMed ID: 16179636
-
Protein phosphatase activity of PTEN inhibited the invasion of glioma cells with epidermal growth factor receptor mutation type III expression.
Cai XM, Tao BB, Wang LY, Liang YL, Jin JW, Yang Y, Hu YL, Zha XL
Int J Cancer. 2005
PubMed ID: 15986432
-
Transforming acidic coiled coil 1 promotes transformation and mammary tumorigenesis.
Cully M, Shiu J, Piekorz RP, Muller WJ, Done SJ, Mak TW
Cancer Res. 2005
PubMed ID: 16288026
-
Heterogeneous tumor evolution initiated by loss of pRb function in a preclinical prostate cancer model.
Hill R, Song Y, Cardiff RD, Van Dyke T
Cancer Res. 2005
PubMed ID: 16288012
-
Postreplicative joining of DNA double-strand breaks causes genomic instability in DNA-PKcs-deficient mouse embryonic fibroblasts.
Martín M, Genescà A, Latre L, Jaco I, Taccioli GE, Egozcue J, Blasco MA, Iliakis G, Tusell L
Cancer Res. 2005
PubMed ID: 16288010
-
Relation of overexpression of S phase kinase-associated protein 2 with reduced expression of p27 and PTEN in human gastric carcinoma.
Ma XM, Liu Y, Guo JW, Liu JH, Zuo LF
World J Gastroenterol. 2005
PubMed ID: 16425372
-
Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer.
Oki E, Baba H, Tokunaga E, Nakamura T, Ueda N, Futatsugi M, Mashino K, Yamamoto M, Ikebe M, Kakeji Y, Maehara Y
Int J Cancer. 2005
PubMed ID: 15900596
-
PTEN-induction in U251 glioma cells decreases the expression of insulin-like growth factor binding protein-2.
Levitt RJ, Georgescu MM, Pollak M
Biochem Biophys Res Commun. 2005
PubMed ID: 16154532
-
Potential prognostic significance of p185(HER2) overexpression with loss of PTEN expression in gastric carcinomas.
Im SA, Lee KE, Nam E, Kim DY, Lee JH, Han HS, Seoh JY, Park HY, Cho MS, Han WS, Lee SN
Tumori. 2005
PubMed ID: 16457151
-
SEL1L affects human pancreatic cancer cell cycle and invasiveness through modulation of PTEN and genes related to cell-matrix interactions.
Cattaneo M, Fontanella E, Canton C, Delia D, Biunno I
Neoplasia. 2005
PubMed ID: 16331889
-
Expression signature of the mouse prostate.
Berquin IM, Min Y, Wu R, Wu H, Chen YQ
J Biol Chem. 2005
PubMed ID: 16055444
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Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice.
Bayascas JR, Leslie NR, Parsons R, Fleming S, Alessi DR
Curr Biol. 2005
PubMed ID: 16243031
-
Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta.
Al-Khouri AM, Ma Y, Togo SH, Williams S, Mustelin T
J Biol Chem. 2005
PubMed ID: 16107342
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TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN.
Vogelmann R, Nguyen-Tat MD, Giehl K, Adler G, Wedlich D, Menke A
J Cell Sci. 2005
PubMed ID: 16219695
-
Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN.
Gao P, Wange RL, Zhang N, Oppenheim JJ, Howard OM
Blood. 2005
PubMed ID: 15994292
-
Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma.
Watanabe S, Horie Y, Suzuki A
Hepatol Res. 2005
PubMed ID: 16214396
-
Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors.
Yang L, Mao C, Teng Y, Li W, Zhang J, Cheng X, Li X, Han X, Xia Z, Deng H, Yang X
Cancer Res. 2005
PubMed ID: 16204035
-
PTEN and p27 expression in mature T-cell and NK-cell neoplasms.
Uner AH, Sağlam A, Han U, Hayran M, Sungur A, Ruacan S
Leuk Lymphoma. 2005
PubMed ID: 16194892
-
Increased protein expression of the PTEN tumor suppressor in the presence of constitutively active Notch-1.
Chappell WH, Green TD, Spengeman JD, McCubrey JA, Akula SM, Bertrand FE
Cell Cycle. 2005
PubMed ID: 16096376
-
PTEN enters the nucleus by diffusion.
Liu F, Wagner S, Campbell RB, Nickerson JA, Schiffer CA, Ross AH
J Cell Biochem. 2005
PubMed ID: 16088943
-
The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN.
Dave B, Eason RR, Till SR, Geng Y, Velarde MC, Badger TM, Simmen RC
Carcinogenesis. 2005
PubMed ID: 15905199
-
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
-
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
-
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
-
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas.
Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y
Cancer Cell. 2005
PubMed ID: 16169464
-
A new mouse model of pancreatic cancer: PTEN gets its Akt together.
Maitra A, Hruban RH
Cancer Cell. 2005
PubMed ID: 16169459
-
Crosstalk between Pten and Ras signaling pathways in tumor development.
To MD, Perez-Losada J, Mao JH, Balmain A
Cell Cycle. 2005
PubMed ID: 16123588
-
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis.
Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A
Genes Dev. 2005
PubMed ID: 16107612
-
The use of genetically engineered mouse models of prostate cancer for nutrition and cancer chemoprevention research.
Klein RD
Mutat Res. 2005
PubMed ID: 15885713
-
Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines.
Goswami R, Singh D, Phillips G, Kilkus J, Dawson G
J Neurosci Res. 2005
PubMed ID: 15968641
-
Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases.
Valiente M, Andrés-Pons A, Gomar B, Torres J, Gil A, Tapparel C, Antonarakis SE, Pulido R
J Biol Chem. 2005
PubMed ID: 15951562
-
FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis.
Bandyopadhyay S, Pai SK, Watabe M, Gross SC, Hirota S, Hosobe S, Tsukada T, Miura K, Saito K, Markwell SJ, Wang Y, Huggenvik J, Pauza ME, Iiizumi M, Watabe K
Oncogene. 2005
PubMed ID: 15897909
-
Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines.
Ma DZ, Xu Z, Liang YL, Su JM, Li ZX, Zhang W, Wang LY, Zha XL
World J Gastroenterol. 2005
PubMed ID: 16052674
-
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis.
Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M, Koutcher JA, Scher HI, Ludwig T, Gerald W, Cordon-Cardo C, Pandolfi PP
Nature. 2005
PubMed ID: 16079851
-
Expression of PTEN in ovarian epithelial tumors and its relation to tumor behavior and growth.
Lee JS, Choi YD, Choi C, Lee MC, Park CS, Min KW
Anal Quant Cytol Histol. 2005
PubMed ID: 16220831
-
[PTEN negatively regulates isoproterenol-induced cardiac hypertrophy and effects of captopril on PTEN expression]
Zhou YZ, Zhu SJ, Yu LJ, Tian Y, Wang J
Zhonghua Xin Xue Guan Bing Za Zhi. 2005
PubMed ID: 16188065
-
Overexpression of the tumor suppressor gene phosphatase and tensin homologue partially inhibits wnt-1-induced mammary tumorigenesis.
Zhao H, Cui Y, Dupont J, Sun H, Hennighausen L, Yakar S
Cancer Res. 2005
PubMed ID: 16061670
-
Loss-of-function of Nkx3.1 promotes increased oxidative damage in prostate carcinogenesis.
Ouyang X, DeWeese TL, Nelson WG, Abate-Shen C
Cancer Res. 2005
PubMed ID: 16061659
-
PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex.
Zhang C, Comai L, Johnson DL
Mol Cell Biol. 2005
PubMed ID: 16055704
-
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2.
Manning BD, Logsdon MN, Lipovsky AI, Abbott D, Kwiatkowski DJ, Cantley LC
Genes Dev. 2005
PubMed ID: 16027169
-
Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression.
Ma L, Teruya-Feldstein J, Behrendt N, Chen Z, Noda T, Hino O, Cordon-Cardo C, Pandolfi PP
Genes Dev. 2005
PubMed ID: 16027168
-
PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma.
Uegaki K, Kanamori Y, Kigawa J, Kawaguchi W, Kaneko R, Naniwa J, Takahashi M, Shimada M, Oishi T, Itamochi H, Terakawa N
Oncol Rep. 2005
PubMed ID: 16012720
-
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.
Mehenni H, Lin-Marq N, Buchet-Poyau K, Reymond A, Collart MA, Picard D, Antonarakis SE
Hum Mol Genet. 2005
PubMed ID: 15987703
-
Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase.
Luo J, Sobkiw CL, Logsdon NM, Watt JM, Signoretti S, O'Connell F, Shin E, Shim Y, Pao L, Neel BG, Depinho RA, Loda M, Cantley LC
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16006513
-
Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.
Mayo LD, Seo YR, Jackson MW, Smith ML, Rivera Guzman J, Korgaonkar CK, Donner DB
J Biol Chem. 2005
PubMed ID: 15843377
-
Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis.
Ma X, Ziel-van der Made AC, Autar B, van der Korput HA, Vermeij M, van Duijn P, Cleutjens KB, de Krijger R, Krimpenfort P, Berns A, van der Kwast TH, Trapman J
Cancer Res. 2005
PubMed ID: 15994948
-
Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.
Liu JL, Sheng X, Hortobagyi ZK, Mao Z, Gallick GE, Yung WK
Mol Cell Biol. 2005
PubMed ID: 15988030
-
PTEN loss inhibits CHK1 to cause double stranded-DNA breaks in cells.
Puc J, Parsons R
Cell Cycle. 2005
PubMed ID: 15970699
-
PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization.
Yue Q, Groszer M, Gil JS, Berk AJ, Messing A, Wu H, Liu X
Development. 2005
PubMed ID: 15944184
-
Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations.
Zhang X, Podsypanina K, Huang S, Mohsin SK, Chamness GC, Hatsell S, Cowin P, Schiff R, Li Y
Oncogene. 2005
PubMed ID: 15824740
-
Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation.
Xiao A, Yin C, Yang C, Di Cristofano A, Pandolfi PP, Van Dyke T
Cancer Res. 2005
PubMed ID: 15958561
-
PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes.
Tang X, Powelka AM, Soriano NA, Czech MP, Guilherme A
J Biol Chem. 2005
PubMed ID: 15824124
-
Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia ind
Phillips RJ, Mestas J, Gharaee-Kermani M, Burdick MD, Sica A, Belperio JA, Keane MP, Strieter RM
J Biol Chem. 2005
PubMed ID: 15802268
-
Malignant glioma: the involvement of loss of allelic heterozygosity and PTEN mutations in a group of Malay patients.
Zainuddin N, Jaafar H, Isa MN, Abdullah JM
Southeast Asian J Trop Med Public Health. 2005
PubMed ID: 16124450
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Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression.
Baak JP, Van Diermen B, Steinbakk A, Janssen E, Skaland I, Mutter GL, Fiane B, Løvslett K
Hum Pathol. 2005
PubMed ID: 15948123
-
The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts.
Ozyildirim AM, Wistow GJ, Gao J, Wang J, Dickinson DP, Frierson HF, Laurie GW
Invest Ophthalmol Vis Sci. 2005
PubMed ID: 15851553
-
Using tumor markers to predict the survival of patients with metastatic renal cell carcinoma.
Kim HL, Seligson D, Liu X, Janzen N, Bui MH, Yu H, Shi T, Belldegrun AS, Horvath S, Figlin RA
J Urol. 2005
PubMed ID: 15821467
-
Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation.
Connor KM, Subbaram S, Regan KJ, Nelson KK, Mazurkiewicz JE, Bartholomew PJ, Aplin AE, Tai YT, Aguirre-Ghiso J, Flores SC, Melendez JA
J Biol Chem. 2005
PubMed ID: 15701646
-
Analysis of mouse embryonic patterning and morphogenesis by forward genetics.
García-García MJ, Eggenschwiler JT, Caspary T, Alcorn HL, Wyler MR, Huangfu D, Rakeman AS, Lee JD, Feinberg EH, Timmer JR, Anderson KV
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15755804
-
PTEN expression in ovine granulosa cells increases during terminal follicular growth.
Froment P, Bontoux M, Pisselet C, Monget P, Dupont J
FEBS Lett. 2005
PubMed ID: 15848175
-
mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma.
Hu X, Pandolfi PP, Li Y, Koutcher JA, Rosenblum M, Holland EC
Neoplasia. 2005
PubMed ID: 15967113
-
Genetic and epigenetic alterations of the PTEN gene in soft tissue sarcomas.
Kawaguchi K, Oda Y, Saito T, Takahira T, Yamamoto H, Tamiya S, Iwamoto Y, Tsuneyoshi M
Hum Pathol. 2005
PubMed ID: 15891996
-
Genotyping of patients with sporadic and radiation-associated meningiomas.
Sadetzki S, Flint-Richter P, Starinsky S, Novikov I, Lerman Y, Goldman B, Friedman E
Cancer Epidemiol Biomarkers Prev. 2005
PubMed ID: 15824172
-
Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations.
Butler MG, Dasouki MJ, Zhou XP, Talebizadeh Z, Brown M, Takahashi TN, Miles JH, Wang CH, Stratton R, Pilarski R, Eng C
J Med Genet. 2005
PubMed ID: 15805158
-
Rho Rocks PTEN.
Meili R, Sasaki AT, Firtel RA
Nat Cell Biol. 2005
PubMed ID: 15803130
-
Regulation of PTEN by Rho small GTPases.
Li Z, Dong X, Dong X, Wang Z, Liu W, Deng N, Ding Y, Tang L, Hla T, Zeng R, Li L, Wu D
Nat Cell Biol. 2005
PubMed ID: 15793569
-
PTEN promoter methylation and protein expression in normal early placentas and hydatidiform moles.
Chen H, Ye D, Xie X, Lu W, Zhu C, Chen X
J Soc Gynecol Investig. 2005
PubMed ID: 15784509
-
Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-kappaB activation in HL-60 cells.
Lee YR, Shim HJ, Yu HN, Song EK, Park J, Kwon KB, Park JW, Rho HW, Park BH, Han MK, Kim JS
Leuk Res. 2005
PubMed ID: 15725474
-
PTEN "meets" DMSO.
Santos NC, Martins-Silva J, Saldanha C
Leuk Res. 2005
PubMed ID: 15725467
-
Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics.
Crockett DK, Fillmore GC, Elenitoba-Johnson KS, Lim MS
Proteomics. 2005
PubMed ID: 15717329
-
Transient strong reduction of PTEN expression by specific RNAi induces loss of adhesion of the cells.
Mise-Omata S, Obata Y, Iwase S, Mise N, Doi TS
Biochem Biophys Res Commun. 2005
PubMed ID: 15707982
-
PTEN as an effector in the signaling of antimigratory G protein-coupled receptor.
Sanchez T, Thangada S, Wu MT, Kontos CD, Wu D, Wu H, Hla T
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15764699
-
Frequent genetic and biochemical alterations of the PI 3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma.
Pedrero JM, Carracedo DG, Pinto CM, Zapatero AH, Rodrigo JP, Nieto CS, Gonzalez MV
Int J Cancer. 2005
PubMed ID: 15543611
-
Elevated PTEN levels account for the increased sensitivity of ethanol-exposed cells to tumor necrosis factor-induced cytotoxicity.
Shulga N, Hoek JB, Pastorino JG
J Biol Chem. 2005
PubMed ID: 15623531
-
Dicer is required for embryonic angiogenesis during mouse development.
Yang WJ, Yang DD, Na S, Sandusky GE, Zhang Q, Zhao G
J Biol Chem. 2005
PubMed ID: 15613470
-
Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors.
Di Vizio D, Cito L, Boccia A, Chieffi P, Insabato L, Pettinato G, Motti ML, Schepis F, D'Amico W, Fabiani F, Tavernise B, Venuta S, Fusco A, Viglietto G
Oncogene. 2005
PubMed ID: 15674339
-
Genotype phenotype correlations in Israeli colorectal cancer patients.
Starinsky S, Figer A, Ben-Asher E, Geva R, Flex D, Fidder HH, Zidan J, Lancet D, Friedman E
Int J Cancer. 2005
PubMed ID: 15523694
-
[Expression of tumor suppressor PTEN in hypertrophy cardiomyocyte]
Wu Y, Hu YE
Zhonghua Xin Xue Guan Bing Za Zhi. 2005
PubMed ID: 15929827
-
DJ-1, a novel regulator of the tumor suppressor PTEN.
Kim RH, Peters M, Jang Y, Shi W, Pintilie M, Fletcher GC, DeLuca C, Liepa J, Zhou L, Snow B, Binari RC, Manoukian AS, Bray MR, Liu FF, Tsao MS, Mak TW
Cancer Cell. 2005
PubMed ID: 15766664
-
Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue.
Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H
Mol Cell Biol. 2005
PubMed ID: 15743841
-
Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2.
Subauste MC, Nalbant P, Adamson ED, Hahn KM
J Biol Chem. 2005
PubMed ID: 15579911
-
Lack of PTEN sequesters CHK1 and initiates genetic instability.
Puc J, Keniry M, Li HS, Pandita TK, Choudhury AD, Memeo L, Mansukhani M, Murty VV, Gaciong Z, Meek SE, Piwnica-Worms H, Hibshoosh H, Parsons R
Cancer Cell. 2005
PubMed ID: 15710331
-
Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia.
Huang J, Niu XL, Pippen AM, Annex BH, Kontos CD
Arterioscler Thromb Vasc Biol. 2005
PubMed ID: 15569824
-
Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen.
Shoman N, Klassen S, McFadden A, Bickis MG, Torlakovic E, Chibbar R
Mod Pathol. 2005
PubMed ID: 15475931
-
Loss of heterozygosity on 10q23.3 and mutation of tumor suppressor gene PTEN in gastric cancer and precancerous lesions.
Li YL, Tian Z, Wu DY, Fu BY, Xin Y
World J Gastroenterol. 2005
PubMed ID: 15633233
-
Deciphering cancer complexities in genetically engineered mice.
Simin K, Hill R, Song Y, Zhang Q, Bash R, Cardiff RD, Yin C, Xiao A, McCarthy K, van Dyke T
Cold Spring Harb Symp Quant Biol. 2005
PubMed ID: 16869764
-
Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice.
Huang S, Li Y, Chen Y, Podsypanina K, Chamorro M, Olshen AB, Desai KV, Tann A, Petersen D, Green JE, Varmus HE
Genome Biol. 2005
PubMed ID: 16207355
-
Reduced expression of PTEN protein and its prognostic implications in invasive ductal carcinoma of the breast.
Tsutsui S, Inoue H, Yasuda K, Suzuki K, Higashi H, Era S, Mori M
Oncology. 2005
PubMed ID: 16020969
-
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
-
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer.
Dinulescu DM, Ince TA, Quade BJ, Shafer SA, Crowley D, Jacks T
Nat Med. 2005
PubMed ID: 15619626
-
Evaluation of germline PTEN mutations in endometrial cancer patients.
Black D, Bogomolniy F, Robson ME, Offit K, Barakat RR, Boyd J
Gynecol Oncol. 2005
PubMed ID: 15589575
-
The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway.
Seo JH, Ahn Y, Lee SR, Yeol Yeo C, Chung Hur K
Mol Biol Cell. 2005
PubMed ID: 15537704
-
PTEN expression elicited by EGR-1 transcription factor in calyculin A-induced apoptotic cells.
Okamura H, Yoshida K, Morimoto H, Haneji T
J Cell Biochem. 2005
PubMed ID: 15517593
-
Regulation of c-Met-dependent gene expression by PTEN.
Abounader R, Reznik T, Colantuoni C, Martinez-Murillo F, Rosen EM, Laterra J
Oncogene. 2004
PubMed ID: 15516982
-
A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.
Gao H, Ouyang X, Banach-Petrosky W, Borowsky AD, Lin Y, Kim M, Lee H, Shih WJ, Cardiff RD, Shen MM, Abate-Shen C
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15569926
-
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
-
The complexity of PTEN: mutation, marker and potential target for therapeutic intervention.
Steelman LS, Bertrand FE, McCubrey JA
Expert Opin Ther Targets. 2004
PubMed ID: 15584861
-
PTEN regulates motility but not directionality during leukocyte chemotaxis.
Lacalle RA, Gómez-Moutón C, Barber DF, Jiménez-Baranda S, Mira E, Martínez-A C, Carrera AC, Mañes S
J Cell Sci. 2004
PubMed ID: 15564381
-
PTEN promoter is methylated in a proportion of invasive breast cancers.
Khan S, Kumagai T, Vora J, Bose N, Sehgal I, Koeffler PH, Bose S
Int J Cancer. 2004
PubMed ID: 15382065
-
Molecular genetic alterations in endometrioid carcinomas of the ovary: similar frequency of beta-catenin abnormalities but lower rate of microsatellite instability and PTEN alterations than in uterine endometrioid carcinomas.
Catasús L, Bussaglia E, Rodrguez I, Gallardo A, Pons C, Irving JA, Prat J
Hum Pathol. 2004
PubMed ID: 15668893
-
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice.
Kim HW, Park IK, Cho CS, Lee KH, Beck GR, Colburn NH, Cho MH
Cancer Res. 2004
PubMed ID: 15520204
-
Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo.
Fraser MM, Zhu X, Kwon CH, Uhlmann EJ, Gutmann DH, Baker SJ
Cancer Res. 2004
PubMed ID: 15520182
-
PTEN permits acute increases in D3-phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt.
Seminario MC, Precht P, Bunnell SC, Warren SE, Morris CM, Taub D, Wange RL
Eur J Immunol. 2004
PubMed ID: 15468057
-
Inactivation of PTEN is associated with increased angiogenesis and VEGF overexpression in gastric cancer.
Zhou YJ, Xiong YX, Wu XT, Shi D, Fan W, Zhou T, Li YC, Huang X
World J Gastroenterol. 2004
PubMed ID: 15457582
-
The involvement of PTEN in sleep deprivation-induced memory impairment in rats.
Su CL, Chen CH, Lu HY, Gean PW
Mol Pharmacol. 2004
PubMed ID: 15317872
-
Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.
Okahara F, Ikawa H, Kanaho Y, Maehama T
J Biol Chem. 2004
PubMed ID: 15355975
-
grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice.
Cully M, Elia A, Ong SH, Stambolic V, Pawson T, Tsao MS, Mak TW
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15492213
-
The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling.
Hagenbeek TJ, Naspetti M, Malergue F, Garçon F, Nunès JA, Cleutjens KB, Trapman J, Krimpenfort P, Spits H
J Exp Med. 2004
PubMed ID: 15452180
-
PTEN mutations do not cause nuclear beta-catenin accumulation in endometrial carcinomas.
Wappenschmidt B, Wardelmann E, Gehrig A, Schöndorf T, Maass N, Bonatz G, Gassel AM, Pietsch T, Mallmann P, Weber BH, Schmutzler RK
Hum Pathol. 2004
PubMed ID: 15492994
-
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
-
17 Beta-estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats.
Choi YC, Lee JH, Hong KW, Lee KS
Fundam Clin Pharmacol. 2004
PubMed ID: 15482376
-
[Analysis of loss of heterozygosity on chromosome 10 in human prostate carcinoma and high grade prostatic intraepithelial neoplasia]
Wang ZM, Lai FM
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004
PubMed ID: 15476185
-
Enhanced cell growth inhibition following PTEN nonviral gene transfer using polyethylenimine and photochemical internalization in endometrial cancer cells.
Maurice-Duelli A, Ndoye A, Bouali S, Leroux A, Merlin JL
Technol Cancer Res Treat. 2004
PubMed ID: 15453811
-
Promoter methylation of the PTEN gene is a common molecular change in breast cancer.
García JM, Silva J, Peña C, Garcia V, Rodríguez R, Cruz MA, Cantos B, Provencio M, España P, Bonilla F
Genes Chromosomes Cancer. 2004
PubMed ID: 15287024
-
Control of phosphatase and tensin homolog (PTEN) gene expression in normal and neoplastic thyroid cells.
Tell G, Pines A, Arturi F, Cesaratto L, Adamson E, Puppin C, Presta I, Russo D, Filetti S, Damante G
Endocrinology. 2004
PubMed ID: 15231710
-
Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells.
Lin HK, Hu YC, Lee DK, Chang C
Mol Endocrinol. 2004
PubMed ID: 15205473
-
PTENless means more.
Stiles B, Groszer M, Wang S, Jiao J, Wu H
Dev Biol. 2004
PubMed ID: 15328005
-
Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity.
Meuillet EJ, Mahadevan D, Berggren M, Coon A, Powis G
Arch Biochem Biophys. 2004
PubMed ID: 15313215
-
Correlation between synaptogenesis and the PTEN phosphatase expression in dendrites during postnatal brain development.
Perandones C, Costanzo RV, Kowaljow V, Pivetta OH, Carminatti H, Radrizzani M
Brain Res Mol Brain Res. 2004
PubMed ID: 15337313
-
PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity.
Gildea JJ, Herlevsen M, Harding MA, Gulding KM, Moskaluk CA, Frierson HF, Theodorescu D
Oncogene. 2004
PubMed ID: 15273733
-
Reduced PTEN expression is associated with poor outcome and angiogenesis in invasive ductal carcinoma of the breast.
Lee JS, Kim HS, Kim YB, Lee MC, Park CS, Min KW
Appl Immunohistochem Mol Morphol. 2004
PubMed ID: 15551732
-
NSAIDs activate PTEN and other phosphatases in human colon cancer cells: novel mechanism for chemopreventive action of NSAIDs.
Chu EC, Chai J, Tarnawski AS
Biochem Biophys Res Commun. 2004
PubMed ID: 15240129
-
PTEN regulates Mdm2 expression through the P1 promoter.
Chang CJ, Freeman DJ, Wu H
J Biol Chem. 2004
PubMed ID: 15090541
-
Association of PTEN mutation with HPV-negative adenocarcinoma of the uterine cervix.
Minaguchi T, Yoshikawa H, Nakagawa S, Yasugi T, Yano T, Iwase H, Mizutani K, Shiromizu K, Ohmi K, Watanabe Y, Noda K, Nishiu M, Nakamura Y, Taketani Y
Cancer Lett. 2004
PubMed ID: 15172121
-
Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines.
Zhang L, Yu Q, He J, Zha X
Mol Cell Biochem. 2004
PubMed ID: 15532706
-
Compound heterozygosity for Pten and SHIP augments T-dependent humoral immune responses and cytokine production by CD(4+) T cells.
Moody JL, Jirik FR
Immunology. 2004
PubMed ID: 15196208
-
Anemia, thrombocytopenia, leukocytosis, extramedullary hematopoiesis, and impaired progenitor function in Pten+/-SHIP-/- mice: a novel model of myelodysplasia.
Moody JL, Xu L, Helgason CD, Jirik FR
Blood. 2004
PubMed ID: 15001465
-
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas.
Horie Y, Suzuki A, Kataoka E, Sasaki T, Hamada K, Sasaki J, Mizuno K, Hasegawa G, Kishimoto H, Iizuka M, Naito M, Enomoto K, Watanabe S, Mak TW, Nakano T
J Clin Invest. 2004
PubMed ID: 15199412
-
Epigenetic and genetic alternation of PTEN in cervical neoplasm.
Cheung TH, Lo KW, Yim SF, Chan LK, Heung MS, Chan CS, Cheung AY, Chung TK, Wong YF
Gynecol Oncol. 2004
PubMed ID: 15196854
-
Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.
Goel A, Arnold CN, Niedzwiecki D, Carethers JM, Dowell JM, Wasserman L, Compton C, Mayer RJ, Bertagnolli MM, Boland CR
Cancer Res. 2004
PubMed ID: 15126336
-
PTEN and other tumor suppressor gene mutations as secondary genetic alterations in synovial sarcoma.
Saito T, Oda Y, Kawaguchi K, Takahira T, Yamamoto H, Tanaka K, Matsuda S, Sakamoto A, Iwamoto Y, Tsuneyoshi M
Oncol Rep. 2004
PubMed ID: 15069540
-
The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages.
Cao X, Wei G, Fang H, Guo J, Weinstein M, Marsh CB, Ostrowski MC, Tridandapani S
J Immunol. 2004
PubMed ID: 15067063
-
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif.
Walker SM, Leslie NR, Perera NM, Batty IH, Downes CP
Biochem J. 2004
PubMed ID: 14711368
-
A requirement of MAPKAPK2 in the uropod localization of PTEN during FMLP-induced neutrophil chemotaxis.
Wu Y, Hannigan MO, Kotlyarov A, Gaestel M, Wu D, Huang CK
Biochem Biophys Res Commun. 2004
PubMed ID: 15033451
-
Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase.
Mahimainathan L, Choudhury GG
J Biol Chem. 2004
PubMed ID: 14718524
-
Human cancer, PTEN and the PI-3 kinase pathway.
Parsons R
Semin Cell Dev Biol. 2004
PubMed ID: 15209376
-
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
-
Functional analysis of the tumour suppressor gene PTEN in murine B cells and keratinocytes.
Suzuki A, Sasaki T, Mak TW, Nakano T
Biochem Soc Trans. 2004
PubMed ID: 15046610
-
The tumour suppressor PTEN: involvement of a tumour suppressor candidate protein in PTEN turnover.
Maehama T, Okahara F, Kanaho Y
Biochem Soc Trans. 2004
PubMed ID: 15046605
-
Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species.
Downes CP, Walker S, McConnachie G, Lindsay Y, Batty IH, Leslie NR
Biochem Soc Trans. 2004
PubMed ID: 15046604
-
Role of PTEN in gastrointestinal stromal tumor progression.
Ricci R, Maggiano N, Castri F, Rinelli A, Murazio M, Pacelli F, Potenza AE, Vecchio FM, Larocca LM
Arch Pathol Lab Med. 2004
PubMed ID: 15043466
-
Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization.
Powles N, Babbs C, Ficker M, Schimmang T, Maconochie M
Dev Biol. 2004
PubMed ID: 15031102
-
Inhibition of neuronal phenotype by PTEN in PC12 cells.
Musatov S, Roberts J, Brooks AI, Pena J, Betchen S, Pfaff DW, Kaplitt MG
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14990793
-
Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.
Raftopoulou M, Etienne-Manneville S, Self A, Nicholls S, Hall A
Science. 2004
PubMed ID: 14976311
-
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected].
Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14769918
-
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten.
Backman SA, Ghazarian D, So K, Sanchez O, Wagner KU, Hennighausen L, Suzuki A, Tsao MS, Chapman WB, Stambolic V, Mak TW
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14747659
-
Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN.
Garl PJ, Wenzlau JM, Walker HA, Whitelock JM, Costell M, Weiser-Evans MC
Circ Res. 2004
PubMed ID: 14656929
-
Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.
Kim S, Domon-Dell C, Kang J, Chung DH, Freund JN, Evers BM
J Biol Chem. 2004
PubMed ID: 14623898
-
Co-downregulation of PTEN, KAI-1, and nm23-H1 tumor/metastasis suppressor proteins in non-small cell lung cancer.
Goncharuk VN, del-Rosario A, Kren L, Anwar S, Sheehan CE, Carlson JA, Ross JS
Ann Diagn Pathol. 2004
PubMed ID: 15129904
-
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
Tsao H, Goel V, Wu H, Yang G, Haluska FG
J Invest Dermatol. 2004
PubMed ID: 15009714
-
The coexistence of ERBB2, INT2, and CMYC oncogene amplifications and PTEN gene mutations in endometrial carcinoma.
Konopka B, Janiec-Jankowska A, Paszko Z, Goluda M
J Cancer Res Clin Oncol. 2004
PubMed ID: 14663583
-
PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells.
Zhao H, Dupont J, Yakar S, Karas M, LeRoith D
Oncogene. 2004
PubMed ID: 14737113
-
PTEN mutations are common in sporadic microsatellite stable colorectal cancer.
Nassif NT, Lobo GP, Wu X, Henderson CJ, Morrison CD, Eng C, Jalaludin B, Segelov E
Oncogene. 2004
PubMed ID: 14724591
-
PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal.
Orchiston EA, Bennett D, Leslie NR, Clarke RG, Winward L, Downes CP, Safrany ST
J Biol Chem. 2004
PubMed ID: 14561749
-
Tumor-derived prostaglandin E2 and transforming growth factor-beta stimulate endothelial cell motility through inhibition of protein phosphatase-2A and involvement of PTEN and phosphatidylinositide 3-kinase.
Young MR
Angiogenesis. 2004
PubMed ID: 15516833
-
Metastatic properties of prostate cancer cells are controlled by VEGF.
Chen J, De S, Brainard J, Byzova TV
Cell Commun Adhes. 2004
PubMed ID: 15500293
-
Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver.
Cui X, Li S, Shraim A, Kobayashi Y, Hayakawa T, Kanno S, Yamamoto M, Hirano S
Toxicol Pathol. 2004
PubMed ID: 14713550
-
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
-
Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation.
Li X, Leu S, Cheong A, Zhang H, Baibakov B, Shih C, Birnbaum MJ, Donowitz M
Gastroenterology. 2004
PubMed ID: 14699494
-
Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer.
Chung MJ, Jung SH, Lee BJ, Kang MJ, Lee DG
Pathol Int. 2004
PubMed ID: 14674989
-
PTEN gene mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastoma.
Kato H, Fujimura M, Kumabe T, Ishioka C, Kanamaru R, Yoshimoto T
J Clin Neurosci. 2004
PubMed ID: 14642363
-
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.
Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, Rowlands T, Egeblad M, Cowin P, Werb Z, Tan LK, Rosen JM, Varmus HE
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14668450
-
Insulin-like growth factor-II regulates PTEN expression in the mammary gland.
Moorehead RA, Hojilla CV, De Belle I, Wood GA, Fata JE, Adamson ED, Watson KL, Edwards DR, Khokha R
J Biol Chem. 2003
PubMed ID: 14517213
-
Pten dose dictates cancer progression in the prostate.
Trotman LC, Niki M, Dotan ZA, Koutcher JA, Di Cristofano A, Xiao A, Khoo AS, Roy-Burman P, Greenberg NM, Van Dyke T, Cordon-Cardo C, Pandolfi PP
PLoS Biol. 2003
PubMed ID: 14691534
-
Akt/PTEN signaling mediates estrogen-dependent proliferation of primordial germ cells in vitro.
Moe-Behrens GH, Klinger FG, Eskild W, Grotmol T, Haugen TB, De Felici M
Mol Endocrinol. 2003
PubMed ID: 14525951
-
Abnormal PTEN expression in portal hypertensive gastric mucosa: a key to impaired PI 3-kinase/Akt activation and delayed injury healing?
Tsugawa K, Jones MK, Akahoshi T, Moon WS, Maehara Y, Hashizume M, Sarfeh IJ, Tarnawski AS
FASEB J. 2003
PubMed ID: 14525948
-
Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN.
Attwell S, Mills J, Troussard A, Wu C, Dedhar S
Mol Biol Cell. 2003
PubMed ID: 12960424
-
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
-
Genetic interactions between Pten and p53 in radiation-induced lymphoma development.
Mao JH, Wu D, Perez-Losada J, Nagase H, DelRosario R, Balmain A
Oncogene. 2003
PubMed ID: 14627978
-
Association of the polymorphisms in the 5'-untranslated region of PTEN gene with type 2 diabetes in a Japanese population.
Ishihara H, Sasaoka T, Kagawa S, Murakami S, Fukui K, Kawagishi Y, Yamazaki K, Sato A, Iwata M, Urakaze M, Ishiki M, Wada T, Yaguchi S, Tsuneki H, Kimura I, Kobayashi M
FEBS Lett. 2003
PubMed ID: 14623110
-
Phosphoinositide 3-kinase cascade facilitates mu-opioid desensitization in sensory neurons by altering G-protein-effector interactions.
Tan M, Groszer M, Tan AM, Pandya A, Liu X, Xie CW
J Neurosci. 2003
PubMed ID: 14614088
-
Loss of PTEN expression is not uncommon, but lacks prognostic value in stage I NSCLC.
Olaussen KA, Soria JC, Morat L, Martin A, Sabatier L, Morere JF, Khayat D, Spano JP
Anticancer Res. 2003
PubMed ID: 14981940
-
Germline inactivation of PTEN and dysregulation of the phosphoinositol-3-kinase/Akt pathway cause human Lhermitte-Duclos disease in adults.
Zhou XP, Marsh DJ, Morrison CD, Chaudhury AR, Maxwell M, Reifenberger G, Eng C
Am J Hum Genet. 2003
PubMed ID: 14566704
-
Expression of the tumor suppressor gene PTEN is not altered in the progression of ovarian carcinomas and does not correlate with p27Kip1 expression.
Schöndorf T, Hoopmann M, Eversheim B, Valter MM, Becker M, Wappenschmidt B, Göhring UJ, Kübler T, Schmutzler RK, Schäfer R
Oncol Rep. 2003
PubMed ID: 14534684
-
mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo.
Kwon CH, Zhu X, Zhang J, Baker SJ
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14534328
-
Redox regulation of PI 3-kinase signalling via inactivation of PTEN.
Leslie NR, Bennett D, Lindsay YE, Stewart H, Gray A, Downes CP
EMBO J. 2003
PubMed ID: 14532122
-
Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.
Lu Y, Yu Q, Liu JH, Zhang J, Wang H, Koul D, McMurray JS, Fang X, Yung WK, Siminovitch KA, Mills GB
J Biol Chem. 2003
PubMed ID: 12869565
-
Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors.
Ruzinova MB, Schoer RA, Gerald W, Egan JE, Pandolfi PP, Rafii S, Manova K, Mittal V, Benezra R
Cancer Cell. 2003
PubMed ID: 14585355
-
PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells.
Zhou M, Gu L, Findley HW, Jiang R, Woods WG
Cancer Res. 2003
PubMed ID: 14559824
-
Regulation of PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression by estradiol and progesterone in human endometrium.
Guzeloglu-Kayisli O, Kayisli UA, Al-Rejjal R, Zheng W, Luleci G, Arici A
J Clin Endocrinol Metab. 2003
PubMed ID: 14557489
-
Role of PTEN and MMP-7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma.
Zheng HC, Sun JM, Li XH, Yang XF, Zhang YC, Xin Y
Pathol Int. 2003
PubMed ID: 14516315
-
Short postoperative survival for glioblastoma patients with a dysfunctional Rb1 pathway in combination with no wild-type PTEN.
Bäcklund LM, Nilsson BR, Goike HM, Schmidt EE, Liu L, Ichimura K, Collins VP
Clin Cancer Res. 2003
PubMed ID: 14519639
-
Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate.
Campbell RB, Liu F, Ross AH
J Biol Chem. 2003
PubMed ID: 12857747
-
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.
Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H
Cancer Cell. 2003
PubMed ID: 14522255
-
Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver.
Yeon JE, Califano S, Xu J, Wands JR, De La Monte SM
Hepatology. 2003
PubMed ID: 12939597
-
PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.
Radu A, Neubauer V, Akagi T, Hanafusa H, Georgescu MM
Mol Cell Biol. 2003
PubMed ID: 12917336
-
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
-
Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions.
Torres J, Rodriguez J, Myers MP, Valiente M, Graves JD, Tonks NK, Pulido R
J Biol Chem. 2003
PubMed ID: 12788938
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Growth, invasion, metastasis, differentiation, angiogenesis and apoptosis of gastric cancer regulated by expression of PTEN encoding products.
Zheng HC, Li YL, Sun JM, Yang XF, Li XH, Jiang WG, Zhang YC, Xin Y
World J Gastroenterol. 2003
PubMed ID: 12918097
-
Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway.
Zhou XP, Waite KA, Pilarski R, Hampel H, Fernandez MJ, Bos C, Dasouki M, Feldman GL, Greenberg LA, Ivanovich J, Matloff E, Patterson A, Pierpont ME, Russo D, Nassif NT, Eng C
Am J Hum Genet. 2003
PubMed ID: 12844284
-
Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells.
Wu W, Wang X, Zhang W, Reed W, Samet JM, Whang YE, Ghio AJ
J Biol Chem. 2003
PubMed ID: 12743124
-
Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases.
Abate-Shen C, Banach-Petrosky WA, Sun X, Economides KD, Desai N, Gregg JP, Borowsky AD, Cardiff RD, Shen MM
Cancer Res. 2003
PubMed ID: 12873978
-
Granular cell tumor in a PHTS patient with a novel germline PTEN mutation.
Marchese C, Montera M, Torrini M, Goldoni F, Mareni C, Forni M, Locatelli L
Am J Med Genet A. 2003
PubMed ID: 12833416
-
Hepatitis B Virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells.
Chung TW, Lee YC, Ko JH, Kim CH
Cancer Res. 2003
PubMed ID: 12839924
-
Membrane-binding and activation mechanism of PTEN.
Das S, Dixon JE, Cho W
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12808147
-
PTEN modulates insulin-like growth factor II (IGF-II)-mediated signaling; the protein phosphatase activity of PTEN downregulates IGF-II expression in hepatoma cells.
Kang-Park S, Lee YI, Lee YI
FEBS Lett. 2003
PubMed ID: 12804776
-
The role of PTEN in the progression and survival of prostate cancer.
Deocampo ND, Huang H, Tindall DJ
Minerva Endocrinol. 2003
PubMed ID: 12717346
-
Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors.
Bianco R, Shin I, Ritter CA, Yakes FM, Basso A, Rosen N, Tsurutani J, Dennis PA, Mills GB, Arteaga CL
Oncogene. 2003
PubMed ID: 12743604
-
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas.
Wang JY, Huang TJ, Chen FM, Hsieh MC, Lin SR, Hou MF, Hsieh JS
Virchows Arch. 2003
PubMed ID: 12695913
-
RRM1-induced metastasis suppression through PTEN-regulated pathways.
Gautam A, Li ZR, Bepler G
Oncogene. 2003
PubMed ID: 12687015
-
Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma.
Byun DS, Cho K, Ryu BK, Lee MG, Park JI, Chae KS, Kim HJ, Chi SG
Int J Cancer. 2003
PubMed ID: 12569555
-
PTEN/MMAC1 mutations correlate inversely with an altered p53 tumor suppressor gene in gynecologic tumors.
Soyoola EO, Pattillo RA
Am J Obstet Gynecol. 2003
PubMed ID: 12712134
-
Combined loss of PTEN and p27 expression is associated with tumor cell proliferation by Ki-67 and increased risk of recurrent disease in localized prostate cancer.
Halvorsen OJ, Haukaas SA, Akslen LA
Clin Cancer Res. 2003
PubMed ID: 12684422
-
Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma.
Kwak YG, Song CH, Yi HK, Hwang PH, Kim JS, Lee KS, Lee YC
J Clin Invest. 2003
PubMed ID: 12671058
-
Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis.
Pineau P, Marchio A, Nagamori S, Seki S, Tiollais P, Dejean A
Hepatology. 2003
PubMed ID: 12668978
-
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production.
Kimura T, Suzuki A, Fujita Y, Yomogida K, Lomeli H, Asada N, Ikeuchi M, Nagy A, Mak TW, Nakano T
Development. 2003
PubMed ID: 12620992
-
Dysregulated PTEN-PKB and negative receptor status in human breast cancer.
Shi W, Zhang X, Pintilie M, Ma N, Miller N, Banerjee D, Tsao MS, Mak T, Fyles A, Liu FF
Int J Cancer. 2003
PubMed ID: 12569575
-
PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocations.
Saito T, Oda Y, Kawaguchi K, Takahira T, Yamamoto H, Tamiya S, Tanaka K, Matsuda S, Sakamoto A, Iwamoto Y, Tsuneyoshi M
Int J Cancer. 2003
PubMed ID: 12569572
-
BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels.
Waite KA, Eng C
Hum Mol Genet. 2003
PubMed ID: 12620973
-
Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.
Suzuki A, Kaisho T, Ohishi M, Tsukio-Yamaguchi M, Tsubata T, Koni PA, Sasaki T, Mak TW, Nakano T
J Exp Med. 2003
PubMed ID: 12615906
-
Expression and significance of PTEN, hypoxia-inducible factor-1 alpha in colorectal adenoma and adenocarcinoma.
Jiang YA, Fan LF, Jiang CQ, Zhang YY, Luo HS, Tang ZJ, Xia D, Wang M
World J Gastroenterol. 2003
PubMed ID: 12632503
-
Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function.
Anzelon AN, Wu H, Rickert RC
Nat Immunol. 2003
PubMed ID: 12563260
-
Mapping of genetic modifiers of thymic lymphoma development in p53-knockout mice.
Ochiai Y, Tamura Y, Saito Y, Matsuki A, Wakabayashi Y, Aizawa Y, Niwa O, Kominami R
Oncogene. 2003
PubMed ID: 12592396
-
PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility.
Sugatani T, Alvarez U, Hruska KA
J Biol Chem. 2003
PubMed ID: 12460992
-
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms.
Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, Whale AD, Martinez-Diaz H, Rozengurt N, Cardiff RD, Liu X, Wu H
Cancer Cell. 2003
PubMed ID: 12620407
-
Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation.
Suzuki A, Itami S, Ohishi M, Hamada K, Inoue T, Komazawa N, Senoo H, Sasaki T, Takeda J, Manabe M, Mak TW, Nakano T
Cancer Res. 2003
PubMed ID: 12566313
-
Activation of PPARgamma increases PTEN expression in pancreatic cancer cells.
Farrow B, Evers BM
Biochem Biophys Res Commun. 2003
PubMed ID: 12535639
-
Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0-G1 in MCF-7 cells.
Ginn-Pease ME, Eng C
Cancer Res. 2003
PubMed ID: 12543774
-
Bannayan-Riley-Ruvalcaba syndrome: further delineation of the phenotype and management of PTEN mutation-positive cases.
Hendriks YM, Verhallen JT, van der Smagt JJ, Kant SG, Hilhorst Y, Hoefsloot L, Hansson KB, van der Straaten PJ, Boutkan H, Breuning MH, Vasen HF, Bröcker-Vriends AH
Fam Cancer. 2003
PubMed ID: 14574156
-
Expression and significance of new tumor suppressor gene PTEN in primary liver cancer.
Dong-Dong L, Xi-Ran Z, Xiang-Rong C
J Cell Mol Med. 2003
PubMed ID: 12767263
-
Loss of a single allele of SHIP exacerbates the immunopathology of Pten heterozygous mice.
Moody JL, Pereira CG, Magil A, Fritzler MJ, Jirik FR
Genes Immun. 2003
PubMed ID: 12595903
-
PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter.
Pore N, Liu S, Haas-Kogan DA, O'Rourke DM, Maity A
Cancer Res. 2003
PubMed ID: 12517803
-
Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis.
Gomez-Manzano C, Fueyo J, Jiang H, Glass TL, Lee HY, Hu M, Liu JL, Jasti SL, Liu TJ, Conrad CA, Yung WK
Ann Neurol. 2003
PubMed ID: 12509854
-
PTEN encoding product: a marker for tumorigenesis and progression of gastric carcinoma.
Yang L, Kuang LG, Zheng HC, Li JY, Wu DY, Zhang SM, Xin Y
World J Gastroenterol. 2003
PubMed ID: 12508347
-
PTEN regulation of neural development and CNS stem cells.
Li L, Liu F, Ross AH
J Cell Biochem. 2003
PubMed ID: 12461771
-
Recurrent allelic imbalance at the rat Pten locus in DMBA-induced fibrosarcomas.
Sjöling A, Samuelson E, Adamovic T, Behboudi A, Röhme D, Levan G
Genes Chromosomes Cancer. 2003
PubMed ID: 12461751
-
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
-
Increased expression of phosphatase and tensin homolog in reactive astrogliosis following intracerebroventricular kainic acid injection in mouse hippocampus.
Cho J, Lee SH, Seo JH, Kim HS, Ahn JG, Kim SS, Yim SV, Song DK, Cho SS
Neurosci Lett. 2002
PubMed ID: 12435489
-
FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer.
Modur V, Nagarajan R, Evers BM, Milbrandt J
J Biol Chem. 2002
PubMed ID: 12351634
-
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
-
PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease.
Wishart MJ, Dixon JE
Trends Cell Biol. 2002
PubMed ID: 12495846
-
Germline mutation of the tumour suppressor PTEN in Proteus syndrome.
Smith JM, Kirk EP, Theodosopoulos G, Marshall GM, Walker J, Rogers M, Field M, Brereton JJ, Marsh DJ
J Med Genet. 2002
PubMed ID: 12471211
-
PTEN inactivation is rare in melanoma tumours but occurs frequently in melanoma cell lines.
Pollock PM, Walker GJ, Glendening JM, Que Noy T, Bloch NC, Fountain JW, Hayward NK
Melanoma Res. 2002
PubMed ID: 12459646
-
Enhanced phosphorylation of PTEN in rat brain after transient middle cerebral artery occlusion.
Omori N, Jin G, Li F, Zhang WR, Wang SJ, Hamakawa Y, Nagano I, Manabe Y, Shoji M, Abe K
Brain Res. 2002
PubMed ID: 12414116
-
Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.
Yang G, Ayala G, De Marzo A, Tian W, Frolov A, Wheeler TM, Thompson TC, Harper JW
Clin Cancer Res. 2002
PubMed ID: 12429629
-
PTEN suppresses hyaluronic acid-induced matrix metalloproteinase-9 expression in U87MG glioblastoma cells through focal adhesion kinase dephosphorylation.
Park MJ, Kim MS, Park IC, Kang HS, Yoo H, Park SH, Rhee CH, Hong SI, Lee SH
Cancer Res. 2002
PubMed ID: 12414663
-
Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas.
Kurose K, Gilley K, Matsumoto S, Watson PH, Zhou XP, Eng C
Nat Genet. 2002
PubMed ID: 12379854
-
Genetic profile, PTEN mutation and therapeutic role of PTEN in glioblastomas.
Fan X, Aalto Y, Sanko SG, Knuutila S, Klatzmann D, Castresana JS
Int J Oncol. 2002
PubMed ID: 12370766
-
Inactivation of the PTEN gene by mutation, exonic deletion, and loss of transcript in human oral squamous cell carcinomas.
Shin KH, Kim JM, Rho KS, Park KH, Oh JE, Min BM
Int J Oncol. 2002
PubMed ID: 12370746
-
PTEN associates with the vault particles in HeLa cells.
Yu Z, Fotouhi-Ardakani N, Wu L, Maoui M, Wang S, Banville D, Shen SH
J Biol Chem. 2002
PubMed ID: 12177006
-
PTEN function in mammalian cell size regulation.
Backman S, Stambolic V, Mak T
Curr Opin Neurobiol. 2002
PubMed ID: 12367630
-
PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway.
Kim S, Domon-Dell C, Wang Q, Chung DH, Di Cristofano A, Pandolfi PP, Freund JN, Evers BM
Gastroenterology. 2002
PubMed ID: 12360479
-
A new locus for resistance to gamma-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice.
Santos J, Montagutelli X, Acevedo A, López P, Vaquero C, Fernández M, Arnau MR, Szatanik M, Salido E, Guénet JL, Fernández-Piqueras J
Oncogene. 2002
PubMed ID: 12242666
-
Direct identification of PTEN phosphorylation sites.
Miller SJ, Lou DY, Seldin DC, Lane WS, Neel BG
FEBS Lett. 2002
PubMed ID: 12297295
-
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.
Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G, Fratta L, Oliveira-dos-Santos AJ, Benovic JL, Kahn CR, Izumo S, Steinberg SF, Wymann MP, Backx PH, Penninger JM
Cell. 2002
PubMed ID: 12297047
-
PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium.
Dupont J, Renou JP, Shani M, Hennighausen L, LeRoith D
J Clin Invest. 2002
PubMed ID: 12235113
-
Silencing of the PTEN tumor-suppressor gene in anaplastic thyroid cancer.
Frisk T, Foukakis T, Dwight T, Lundberg J, Höög A, Wallin G, Eng C, Zedenius J, Larsson C
Genes Chromosomes Cancer. 2002
PubMed ID: 12203792
-
CCND1- and ERBB2-gene deregulation and PTEN mutation analyses in invasive lobular carcinoma of the breast.
Mercapide J, Zhang SY, Fan X, Furió-Bacete V, Schneider J, López de la Osa I, Patchefsky AS, Klein-Szanto AJ, Castresana JS
Mol Carcinog. 2002
PubMed ID: 12203362
-
PTEN, DMBT1, and p16 alterations in diffusely infiltrating astrocytomas.
Fan X, Muñoz J, Sanko SG, Castresana JS
Int J Oncol. 2002
PubMed ID: 12168116
-
MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer.
Koul D, Shen R, Garyali A, Ke LD, Liu TJ, Yung WK
Int J Oncol. 2002
PubMed ID: 12168088
-
Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.
Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H
Development. 2002
PubMed ID: 12163417
-
Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1.
Caselli A, Mazzinghi B, Camici G, Manao G, Ramponi G
Biochem Biophys Res Commun. 2002
PubMed ID: 12176037
-
PTEN expression is associated with prognosis for patients with advanced endometrial carcinoma undergoing postoperative chemotherapy.
Kanamori Y, Kigawa J, Itamochi H, Sultana H, Suzuki M, Ohwada M, Kamura T, Sugiyama T, Kikuchi Y, Kita T, Fujiwara K, Terakawa N
Int J Cancer. 2002
PubMed ID: 12209607
-
Impact of PTEN expression on the outcome of hepatitis C virus-positive cirrhotic hepatocellular carcinoma patients: possible relationship with COX II and inducible nitric oxide synthase.
Rahman MA, Kyriazanos ID, Ono T, Yamanoi A, Kohno H, Tsuchiya M, Nagasue N
Int J Cancer. 2002
PubMed ID: 12115563
-
Downregulation of PTEN/MMAC/TEP1 expression in human prostate cancer cell line DU145 by growth stimuli.
Bastola DR, Pahwa GS, Lin MF, Cheng PW
Mol Cell Biochem. 2002
PubMed ID: 12190124
-
The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells.
Xu Z, Stokoe D, Kane LP, Weiss A
Cell Growth Differ. 2002
PubMed ID: 12133897
-
PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.
Marino S, Krimpenfort P, Leung C, van der Korput HA, Trapman J, Camenisch I, Berns A, Brandner S
Development. 2002
PubMed ID: 12091320
-
Pten signaling in gliomas.
Knobbe CB, Merlo A, Reifenberger G
Neuro Oncol. 2002
PubMed ID: 12084351
-
Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation.
Birle D, Bottini N, Williams S, Huynh H, deBelle I, Adamson E, Mustelin T
J Immunol. 2002
PubMed ID: 12077256
-
Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.
Cook JA, August A, Henderson AJ
J Immunol. 2002
PubMed ID: 12077252
-
Disruption of a single Pten allele augments the chemotactic response of B lymphocytes to stromal cell-derived factor-1.
Fox JA, Ung K, Tanlimco SG, Jirik FR
J Immunol. 2002
PubMed ID: 12077227
-
Reversible inactivation of the tumor suppressor PTEN by H2O2.
Lee SR, Yang KS, Kwon J, Lee C, Jeong W, Rhee SG
J Biol Chem. 2002
PubMed ID: 11916965
-
Expression and significance of a new tumor suppression gene PTEN in primary renal cell carcinoma.
Guo SP, Zhai YQ, Wang WL, Ma FC
Ai Zheng. 2002
PubMed ID: 12452054
-
Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis.
Eng C
Ann N Y Acad Sci. 2002
PubMed ID: 12119278
-
Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis.
Stiles B, Gilman V, Khanzenzon N, Lesche R, Li A, Qiao R, Liu X, Wu H
Mol Cell Biol. 2002
PubMed ID: 11997518
-
A novel germline mutation of PTEN associated with brain tumours of multiple lineages.
Staal FJ, van der Luijt RB, Baert MR, van Drunen J, van Bakel H, Peters E, de Valk I, van Amstel HK, Taphoorn MJ, Jansen GH, van Veelen CW, Burgering B, Staal GE
Br J Cancer. 2002
PubMed ID: 12085208
-
PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation.
Li L, Liu F, Salmonsen RA, Turner TK, Litofsky NS, Di Cristofano A, Pandolfi PP, Jones SN, Recht LD, Ross AH
Mol Cell Neurosci. 2002
PubMed ID: 12056837
-
A 39-bp deletion polymorphism in PTEN in African American individuals: implications for molecular diagnostic testing.
Zhou XP, Hampel H, Roggenbuck J, Saba N, Prior TW, Eng C
J Mol Diagn. 2002
PubMed ID: 11986403
-
Loss of tumor suppressor protein PTEN during renal carcinogenesis.
Brenner W, Färber G, Herget T, Lehr HA, Hengstler JG, Thüroff JW
Int J Cancer. 2002
PubMed ID: 11948491
-
Assessment of the quality and frequency of mutations occurrence in PTEN gene in endometrial carcinomas and hyperplasias.
Konopka B, Paszko Z, Janiec-Jankowska A, Goluda M
Cancer Lett. 2002
PubMed ID: 11849740
-
Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.
Koul D, Jasser SA, Lu Y, Davies MA, Shen R, Shi Y, Mills GB, Yung WK
Oncogene. 2002
PubMed ID: 11948419
-
Reduced expression of PTEN correlates with breast cancer progression.
Bose S, Crane A, Hibshoosh H, Mansukhani M, Sandweis L, Parsons R
Hum Pathol. 2002
PubMed ID: 12055674
-
DNA mismatch repair deficiency accelerates endometrial tumorigenesis in Pten heterozygous mice.
Wang H, Douglas W, Lia M, Edelmann W, Kucherlapati R, Podsypanina K, Parsons R, Ellenson LH
Am J Pathol. 2002
PubMed ID: 11943731
-
The phosphatidylinositol phosphatase PTEN is under control of costimulation and regulates proliferation in human T cells.
Schmidt-Weber CB, Wohlfahrt JG, Akdis CA, Blaser K
Eur J Immunol. 2002
PubMed ID: 11932928
-
PTEN mutations in uterine sarcomas.
Amant F, de la Rey M, Dorfling CM, van der Walt L, Dreyer G, Dreyer L, Vergote I, Lindeque BG, Van Rensburg EJ
Gynecol Oncol. 2002
PubMed ID: 11925138
-
Protean PTEN: form and function.
Waite KA, Eng C
Am J Hum Genet. 2002
PubMed ID: 11875759
-
Promoter analysis of tumor suppressor gene PTEN: identification of minimum promoter region.
Sheng X, Koul D, Liu JL, Liu TJ, Yung WK
Biochem Biophys Res Commun. 2002
PubMed ID: 11906179
-
PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit.
Mayo MW, Madrid LV, Westerheide SD, Jones DR, Yuan XJ, Baldwin AS, Whang YE
J Biol Chem. 2002
PubMed ID: 11799112
-
PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects.
Huang J, Kontos CD
J Biol Chem. 2002
PubMed ID: 11784722
-
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.
Kim MJ, Cardiff RD, Desai N, Banach-Petrosky WA, Parsons R, Shen MM, Abate-Shen C
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11854455
-
Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation.
Xiao A, Wu H, Pandolfi PP, Louis DN, Van Dyke T
Cancer Cell. 2002
PubMed ID: 12086874
-
Reduced PTEN expression in gastric cancer and in the gastric mucosa of gastric cancer relatives.
Fei G, Ebert MP, Mawrin C, Leodolter A, Schmidt N, Dietzmann K, Malfertheiner P
Eur J Gastroenterol Hepatol. 2002
PubMed ID: 11953696
-
Promoter methylation and silencing of PTEN in gastric carcinoma.
Kang YH, Lee HS, Kim WH
Lab Invest. 2002
PubMed ID: 11896207
-
PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow.
Haier J, Nicolson GL
Oncogene. 2002
PubMed ID: 11857088
-
Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumors.
Zhou XP, Kuismanen S, Nystrom-Lahti M, Peltomaki P, Eng C
Hum Mol Genet. 2002
PubMed ID: 11854177
-
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy.
Mayo LD, Dixon JE, Durden DL, Tonks NK, Donner DB
J Biol Chem. 2002
PubMed ID: 11729185
-
Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice.
You MJ, Castrillon DH, Bastian BC, O'Hagan RC, Bosenberg MW, Parsons R, Chin L, DePinho RA
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11818530
-
Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene.
Lesche R, Groszer M, Gao J, Wang Y, Messing A, Sun H, Liu X, Wu H
Genesis. 2002
PubMed ID: 11857804
-
Exclusion of PTEN, CTNNB1, and PTCH as candidate genes for Birt-Hogg-Dube syndrome.
Toro JR, Shevchenko YO, Compton JG, Bale SJ
J Med Genet. 2002
PubMed ID: 11836379
-
Reduced PTEN expression in the pancreas overexpressing transforming growth factor-beta 1.
Ebert MP, Fei G, Schandl L, Mawrin C, Dietzmann K, Herrera P, Friess H, Gress TM, Malfertheiner P
Br J Cancer. 2002
PubMed ID: 11870516
-
Identification of germline mutation of PTEN gene and analysis of apoptosis resistance of the lymphocytes in a patient with Cowden disease.
Kanaseki T, Torigoe T, Hirohashi Y, Hirai I, Himi T, Sato N
Pathobiology. 2002
PubMed ID: 12415190
-
Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10.
Poetsch M, Lorenz G, Kleist B
Cancer Genet Cytogenet. 2002
PubMed ID: 11801303
-
Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex.
Vazquez F, Grossman SR, Takahashi Y, Rokas MV, Nakamura N, Sellers WR
J Biol Chem. 2001
PubMed ID: 11707428
-
PTEN gene mutations in colorectal cancers displaying microsatellite instability.
Shin KH, Park YJ, Park JG
Cancer Lett. 2001
PubMed ID: 11689295
-
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.
Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack JA, Kornblum HI, Liu X, Wu H
Science. 2001
PubMed ID: 11691952
-
Colorectal carcinomas and PTEN/MMAC1 gene mutations.
Dicuonzo G, Angeletti S, Garcia-Foncillas J, Brugarolas A, Okrouzhnov Y, Santini D, Tonini G, Lorino G, De Cesaris M, Baldi A
Clin Cancer Res. 2001
PubMed ID: 11751500
-
A novel germline mutation of the PTEN gene in a patient with macrocephaly, ventricular dilatation, and features of VATER association.
Reardon W, Zhou XP, Eng C
J Med Genet. 2001
PubMed ID: 11748304
-
Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease.
Kwon CH, Zhu X, Zhang J, Knoop LL, Tharp R, Smeyne RJ, Eberhart CG, Burger PC, Baker SJ
Nat Genet. 2001
PubMed ID: 11726927
-
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease.
Backman SA, Stambolic V, Suzuki A, Haight J, Elia A, Pretorius J, Tsao MS, Shannon P, Bolon B, Ivy GO, Mak TW
Nat Genet. 2001
PubMed ID: 11726926
-
PTEN does not modulate GLUT4 translocation in rat adipose cells under physiological conditions.
Mosser VA, Li Y, Quon MJ
Biochem Biophys Res Commun. 2001
PubMed ID: 11689011
-
Akt and PTEN: new diagnostic markers of non-small cell lung cancer?
David O
J Cell Mol Med. 2001
PubMed ID: 12067477
-
Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression.
Kwabi-Addo B, Giri D, Schmidt K, Podsypanina K, Parsons R, Greenberg N, Ittmann M
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11553783
-
The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival.
Schwartzbauer G, Robbins J
J Biol Chem. 2001
PubMed ID: 11448956
-
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice.
Podsypanina K, Lee RT, Politis C, Hennessy I, Crane A, Puc J, Neshat M, Wang H, Yang L, Gibbons J, Frost P, Dreisbach V, Blenis J, Gaciong Z, Fisher P, Sawyers C, Hedrick-Ellenson L, Parsons R
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11504907
-
PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme.
Smith JS, Tachibana I, Passe SM, Huntley BK, Borell TJ, Iturria N, O'Fallon JR, Schaefer PL, Scheithauer BW, James CD, Buckner JC, Jenkins RB
J Natl Cancer Inst. 2001
PubMed ID: 11504770
-
PTEN mutations are uncommon in Proteus syndrome.
Barker K, Martinez A, Wang R, Bevan S, Murday V, Shipley J, Houlston R, Harper J
J Med Genet. 2001
PubMed ID: 11476065
-
Rapid mutation scanning of genes associated with familial cancer syndromes using denaturing high-performance liquid chromatography.
Marsh DJ, Theodosopoulos G, Howell V, Richardson AL, Benn DE, Proos AL, Eng C, Robinson BG
Neoplasia. 2001
PubMed ID: 11494117
-
T cell-specific loss of Pten leads to defects in central and peripheral tolerance.
Suzuki A, Yamaguchi MT, Ohteki T, Sasaki T, Kaisho T, Kimura Y, Yoshida R, Wakeham A, Higuchi T, Fukumoto M, Tsubata T, Ohashi PS, Koyasu S, Penninger JM, Nakano T, Mak TW
Immunity. 2001
PubMed ID: 11371355
-
Evidence of a possible epigenetic inactivation mechanism operating on a region of mouse chromosome 19 in gamma-radiation-induced thymic lymphomas.
Santos J, Herranz M, Fernández M, Vaquero C, López P, Fernández-Piqueras J
Oncogene. 2001
PubMed ID: 11360203
-
Allelic loss of 10q23, the PTEN tumour suppressor gene locus, in Barrett's oesophagus-associated adenocarcinoma.
Kulke MH, Odze RD, Thakore KS, Thomas G, Wang H, Loda M, Eng C
Br J Cancer. 2001
PubMed ID: 11259087
-
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model.
Weng LP, Brown JL, Eng C
Hum Mol Genet. 2001
PubMed ID: 11230179
-
An intronic variant in PTEN is not associated with prostate cancer risk.
Nathanson KL, Omaruddin R, Malkowicz SB, Rebbeck TR
Cancer Epidemiol Biomarkers Prev. 2001
PubMed ID: 11303600
-
Mutation of the PTEN gene in advanced cervical cancer correlated with tumor progression and poor outcome after radiotherapy.
Harima Y, Sawada S, Nagata K, Sougawa M, Ostapenko V, Ohnishi T
Int J Oncol. 2001
PubMed ID: 11179477
-
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
-
Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus.
Hansen L, Jensen JN, Ekstrøm CT, Vestergaard H, Hansen T, Pedersen O
Diabetologia. 2001
PubMed ID: 11270682
-
Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse.
Di Cristofano A, De Acetis M, Koff A, Cordon-Cardo C, Pandolfi PP
Nat Genet. 2001
PubMed ID: 11175795
-
Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Tsujiuchi T, Sasaki Y, Tsutsumi M, Konishi Y
Cancer Lett. 2001
PubMed ID: 11146227
-
PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines.
Kondo K, Yao M, Kobayashi K, Ota S, Yoshida M, Kaneko S, Baba M, Sakai N, Kishida T, Kawakami S, Uemura H, Nagashima Y, Nakatani Y, Hosaka M
Int J Cancer. 2001
PubMed ID: 11146448
-
Mutational analysis of the PTEN gene in endometrial carcinoma and hyperplasia.
Sun H, Enomoto T, Fujita M, Wada H, Yoshino K, Ozaki K, Nakamura T, Murata Y
Am J Clin Pathol. 2001
PubMed ID: 11190805
-
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice.
Li Y, Podsypanina K, Liu X, Crane A, Tan LK, Parsons R, Varmus HE
BMC Mol Biol. 2001
PubMed ID: 11178110
-
Genetic heterogeneity in familial juvenile polyposis.
Huang SC, Chen CR, Lavine JE, Taylor SF, Newbury RO, Pham TT, Ricciardiello L, Carethers JM
Cancer Res. 2000
PubMed ID: 11156385
-
Alternative splicing of the human PTEN/MMAC1/TEP1 gene.
Sharrard RM, Maitland NJ
Biochim Biophys Acta. 2000
PubMed ID: 11121587
-
Molecular analysis of PTEN and MXI1 in primary bladder carcinoma.
Wang DS, Rieger-Christ K, Latini JM, Moinzadeh A, Stoffel J, Pezza JA, Saini K, Libertino JA, Summerhayes IC
Int J Cancer. 2000
PubMed ID: 11058880
-
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
-
Large-scale screen for genes involved in gonad development.
Wertz K, Herrmann BG
Mech Dev. 2000
PubMed ID: 11044607
-
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
-
Single mutations of the PTEN gene in recurrent ovarian carcinomas.
Schöndorf T, Dostal A, Grabmann J, Göhring UJ
J Soc Gynecol Investig. 2000
PubMed ID: 11035285
-
Identification of PTEN mutations in metastatic melanoma specimens.
Celebi JT, Shendrik I, Silvers DN, Peacocke M
J Med Genet. 2000
PubMed ID: 10978354
-
Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat.
Szpirer C, Van Vooren P, Rivière M, Scohy S, Collau G, Szpirer J
Mamm Genome. 2000
PubMed ID: 10967130
-
Somatic mutation of PTEN in vulvar cancer.
Holway AH, Rieger-Christ KM, Miner WR, Cain JW, Dugan JM, Pezza JA, Silverman ML, Shapter A, McLellan R, Summerhayes IC
Clin Cancer Res. 2000
PubMed ID: 10955808
-
Subcellular localization of intracellular protein tyrosine phosphatases in T cells.
Gjörloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M, Oh P, Williams S, Schnitzer J, Mustelin T
Eur J Immunol. 2000
PubMed ID: 10940933
-
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
-
Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase.
Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q, Lasky LA
J Biol Chem. 2000
PubMed ID: 10748157
-
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice.
Stambolic V, Tsao MS, Macpherson D, Suzuki A, Chapman WB, Mak TW
Cancer Res. 2000
PubMed ID: 10910075
-
Phosphorylation of the PTEN tail regulates protein stability and function.
Vazquez F, Ramaswamy S, Nakamura N, Sellers WR
Mol Cell Biol. 2000
PubMed ID: 10866658
-
PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1.
Bruni P, Boccia A, Baldassarre G, Trapasso F, Santoro M, Chiappetta G, Fusco A, Viglietto G
Oncogene. 2000
PubMed ID: 10918569
-
Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay.
Han SY, Kato H, Kato S, Suzuki T, Shibata H, Ishii S, Shiiba K, Matsuno S, Kanamaru R, Ishioka C
Cancer Res. 2000
PubMed ID: 10866302
-
Changes in endometrial PTEN expression throughout the human menstrual cycle.
Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Eng C
J Clin Endocrinol Metab. 2000
PubMed ID: 10852473
-
Absence of PTEN/MMAC1 pseudogene in mice.
Kwabi-Addo B, Thompson TC, Ittmann M
DNA Cell Biol. 2000
PubMed ID: 10855797
-
The expression profile for the tumour suppressor gene PTEN and associated polymorphic markers.
Hamilton JA, Stewart LM, Ajayi L, Gray IC, Gray NE, Roberts KG, Watson GJ, Kaisary AV, Snary D
Br J Cancer. 2000
PubMed ID: 10817502
-
Novel germline mutations in the PTEN tumour suppressor gene found in women with multiple cancers.
De Vivo I, Gertig DM, Nagase S, Hankinson SE, O'Brien R, Speizer FE, Parsons R, Hunter DJ
J Med Genet. 2000
PubMed ID: 10807691
-
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2.
Wu X, Hepner K, Castelino-Prabhu S, Do D, Kaye MB, Yuan XJ, Wood J, Ross C, Sawyers CL, Whang YE
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10760291
-
[Loss and inactivation of PTEN/MMAC1/TEP1 gene in lung cancer]
Zhang L, Liu T, Liu H, Gao J, Gu C
Zhonghua Bing Li Xue Za Zhi. 2000
PubMed ID: 11866895
-
Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia.
Liu TC, Lin PM, Chang JG, Lee JP, Chen TP, Lin SF
Am J Hematol. 2000
PubMed ID: 10706759
-
Homozygous deletion of the PTEN tumor-suppressor gene is not a feature in oral squamous cell carcinoma.
Chen Q, Samaranayake LP, Zhou H, Xiao L
Oral Oncol. 2000
PubMed ID: 10889927
-
Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding.
Adey NB, Huang L, Ormonde PA, Baumgard ML, Pero R, Byreddy DV, Tavtigian SV, Bartel PL
Cancer Res. 2000
PubMed ID: 10646847
-
Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas.
Hu YC, Lam KY, Tang JC, Srivastava G
Mol Pathol. 1999
PubMed ID: 10748870
-
PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death.
Weng LP, Smith WM, Dahia PL, Ziebold U, Gil E, Lees JA, Eng C
Cancer Res. 1999
PubMed ID: 10582703
-
Regulation of PTEN expression in neuronal apoptosis.
Kyrylenko S, Roschier M, Korhonen P, Salminen A
Brain Res Mol Brain Res. 1999
PubMed ID: 10581415
-
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.
Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP
Cell. 1999
PubMed ID: 10555148
-
Impaired Fas response and autoimmunity in Pten+/- mice.
Di Cristofano A, Kotsi P, Peng YF, Cordon-Cardo C, Elkon KB, Pandolfi PP
Science. 1999
PubMed ID: 10497129
-
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region.
Georgescu MM, Kirsch KH, Akagi T, Shishido T, Hanafusa H
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10468583
-
PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome.
Marsh DJ, Kum JB, Lunetta KL, Bennett MJ, Gorlin RJ, Ahmed SF, Bodurtha J, Crowe C, Curtis MA, Dasouki M, Dunn T, Feit H, Geraghty MT, Graham JM, Hodgson SV, Hunter A, Korf BR, Manchester D, Miesfeldt S, Murday VA, Nathanson KL, Parisi M, Pober B, Romano C, Eng C
Hum Mol Genet. 1999
PubMed ID: 10400993
-
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway.
Tamura M, Gu J, Danen EH, Takino T, Miyamoto S, Yamada KM
J Biol Chem. 1999
PubMed ID: 10400703
-
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway.
Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Gavrilova N, Mueller B, Liu X, Wu H
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10339565
-
PTEN/MMAC1 mutations in hepatocellular carcinomas.
Yao YJ, Ping XL, Zhang H, Chen FF, Lee PK, Ahsan H, Chen CJ, Lee PH, Peacocke M, Santella RM, Tsou HC
Oncogene. 1999
PubMed ID: 10340391
-
Elevated frequency of loss of heterozygosity in mammary tumors arising in mouse mammary tumor virus/neu transgenic mice.
Cool M, Jolicoeur P
Cancer Res. 1999
PubMed ID: 10344755
-
Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development.
Luukko K, Ylikorkala A, Tiainen M, Mäkelä TP
Mech Dev. 1999
PubMed ID: 10381580
-
Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.
Sano T, Lin H, Chen X, Langford LA, Koul D, Bondy ML, Hess KR, Myers JN, Hong YK, Yung WK, Steck PA
Cancer Res. 1999
PubMed ID: 10213484
-
Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations.
Nelen MR, Kremer H, Konings IB, Schoute F, van Essen AJ, Koch R, Woods CG, Fryns JP, Hamel B, Hoefsloot LH, Peeters EA, Padberg GW
Eur J Hum Genet. 1999
PubMed ID: 10234502
-
PTEN: a tumour suppressor that functions as a phospholipid phosphatase.
Maehama T, Dixon JE
Trends Cell Biol. 1999
PubMed ID: 10203785
-
Analysis of PTEN mutations and deletions in B-cell non-Hodgkin's lymphomas.
Butler MP, Wang SI, Chaganti RS, Parsons R, Dalla-Favera R
Genes Chromosomes Cancer. 1999
PubMed ID: 10092130
-
A mouse chromosome 19 genetic map including the Lvis1 viral insertion site.
Hansen GM, Tackles D, Schwartz C, Justice MJ
Genomics. 1999
PubMed ID: 10051411
-
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems.
Podsypanina K, Ellenson LH, Nemes A, Gu J, Tamura M, Yamada KM, Cordon-Cardo C, Catoretti G, Fisher PE, Parsons R
Proc Natl Acad Sci U S A. 1999
PubMed ID: 9990064
-
Severe Lhermitte-Duclos disease with unique germline mutation of PTEN.
Sutphen R, Diamond TM, Minton SE, Peacocke M, Tsou HC, Root AW
Am J Med Genet. 1999
PubMed ID: 10051160
-
Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.
Tamura M, Gu J, Takino T, Yamada KM
Cancer Res. 1999
PubMed ID: 9927060
-
Variant manifestation of Cowden disease in Japan: hamartomatous polyposis of the digestive tract with mutation of the PTEN gene.
Kurose K, Araki T, Matsunaka T, Takada Y, Emi M
Am J Hum Genet. 1999
PubMed ID: 9915974
-
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
-
Mouse models in tumor suppression.
Ghebranious N, Donehower LA
Oncogene. 1998
PubMed ID: 9917000
-
The Ptentative nature of mouse knockouts.
Bradley A, Luo G
Nat Genet. 1998
PubMed ID: 9843198
-
Identification of a novel PTEN mutation (L139X) in a patient with Cowden disease and Sjögren's syndrome.
Raizis AM, Ferguson MM, Robinson BA, Atkinson CH, George PM
Mol Pathol. 1998
PubMed ID: 10193515
-
The lipid phosphatase activity of PTEN is critical for its tumor supressor function.
Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP, Tonks NK
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9811831
-
Germline PTEN mutations in Cowden syndrome-like families.
Marsh DJ, Dahia PL, Caron S, Kum JB, Frayling IM, Tomlinson IP, Hughes KS, Eeles RA, Hodgson SV, Murday VA, Houlston R, Eng C
J Med Genet. 1998
PubMed ID: 9832031
-
Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease.
Chi SG, Kim HJ, Park BJ, Min HJ, Park JH, Kim YW, Dong SH, Kim BH, Lee JI, Chang YW, Chang R, Kim WK, Yang MH
Gastroenterology. 1998
PubMed ID: 9797362
-
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.
Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I, Ho A, Wakeham A, Itie A, Khoo W, Fukumoto M, Mak TW
Curr Biol. 1998
PubMed ID: 9799734
-
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.
Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP, Mak TW
Cell. 1998
PubMed ID: 9778245
-
Novel mutation of the PTEN gene in an Italian Cowden's disease kindred.
Scala S, Bruni P, Lo Muzio L, Mignogna M, Viglietto G, Fusco A
Int J Oncol. 1998
PubMed ID: 9735393
-
Mutation analysis of the PTEN/MMAC1 gene in lung cancer.
Forgacs E, Biesterveld EJ, Sekido Y, Fong K, Muneer S, Wistuba II, Milchgrub S, Brezinschek R, Virmani A, Gazdar AF, Minna JD
Oncogene. 1998
PubMed ID: 9794233
-
Pten is essential for embryonic development and tumour suppression.
Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP
Nat Genet. 1998
PubMed ID: 9697695
-
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers.
Cairns P, Evron E, Okami K, Halachmi N, Esteller M, Herman JG, Bose S, Wang SI, Parsons R, Sidransky D
Oncogene. 1998
PubMed ID: 9671402
-
Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias.
Maxwell GL, Risinger JI, Gumbs C, Shaw H, Bentley RC, Barrett JC, Berchuck A, Futreal PA
Cancer Res. 1998
PubMed ID: 9635567
-
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN.
Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM
Science. 1998
PubMed ID: 9616126
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.
Maehama T, Dixon JE
J Biol Chem. 1998
PubMed ID: 9593664
-
The genetic basis of Cowden's syndrome: three novel mutations in PTEN/MMAC1/TEP1.
Tsou HC, Ping XL, Xie XX, Gruener AC, Zhang H, Nini R, Swisshelm K, Sybert V, Diamond TM, Sutphen R, Peacocke M
Hum Genet. 1998
PubMed ID: 9600246
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Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation.
Marsh DJ, Coulon V, Lunetta KL, Rocca-Serra P, Dahia PL, Zheng Z, Liaw D, Caron S, Duboué B, Lin AY, Richardson AL, Bonnetblanc JM, Bressieux JM, Cabarrot-Moreau A, Chompret A, Demange L, Eeles RA, Yahanda AM, Fearon ER, Fricker JP, Gorlin RJ, Hodgson SV, Huson S, Lacombe D, Eng C
Hum Mol Genet. 1998
PubMed ID: 9467011
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Pten, a candidate tumor suppressor gene, maps to mouse chromosome 19.
Hansen GM, Justice MJ
Mamm Genome. 1998
PubMed ID: 9434957
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PTEN germ-line mutations in juvenile polyposis coli.
Olschwang S, Serova-Sinilnikova OM, Lenoir GM, Thomas G
Nat Genet. 1998
PubMed ID: 9425889
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Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis.
Lynch ED, Ostermeyer EA, Lee MK, Arena JF, Ji H, Dann J, Swisshelm K, Suchard D, MacLeod PM, Kvinnsland S, Gjertsen BT, Heimdal K, Lubs H, Møller P, King MC
Am J Hum Genet. 1997
PubMed ID: 9399897
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PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.
Liu W, James CD, Frederick L, Alderete BE, Jenkins RB
Cancer Res. 1997
PubMed ID: 9393744
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A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.
Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE
J Biol Chem. 1997
PubMed ID: 9367992
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Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain.
Furnari FB, Lin H, Huang HS, Cavenee WK
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9356475
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PTEN/MMAC1 mutations in endometrial cancers.
Risinger JI, Hayes AK, Berchuck A, Barrett JC
Cancer Res. 1997
PubMed ID: 9354433
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Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors.
Dahia PL, Marsh DJ, Zheng Z, Zedenius J, Komminoth P, Frisk T, Wallin G, Parsons R, Longy M, Larsson C, Eng C
Cancer Res. 1997
PubMed ID: 9354427
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The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases.
Tsou HC, Teng DH, Ping XL, Brancolini V, Davis T, Hu R, Xie XX, Gruener AC, Schrager CA, Christiano AM, Eng C, Steck P, Ott J, Tavtigian SV, Peacocke M
Am J Hum Genet. 1997
PubMed ID: 9345101
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Somatic mutations of PTEN in glioblastoma multiforme.
Wang SI, Puc J, Li J, Bruce JN, Cairns P, Sidransky D, Parsons R
Cancer Res. 1997
PubMed ID: 9331071
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Deletion of PTEN in a patient with Bannayan-Riley-Ruvalcaba syndrome suggests allelism with Cowden disease.
Arch EM, Goodman BK, Van Wesep RA, Liaw D, Clarke K, Parsons R, McKusick VA, Geraghty MT
Am J Med Genet. 1997
PubMed ID: 9286463
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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase.
Myers MP, Stolarov JP, Eng C, Li J, Wang SI, Wigler MH, Parsons R, Tonks NK
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9256433
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Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.
Nelen MR, van Staveren WC, Peeters EA, Hassel MB, Gorlin RJ, Hamm H, Lindboe CF, Fryns JP, Sijmons RH, Woods DG, Mariman EC, Padberg GW, Kremer H
Hum Mol Genet. 1997
PubMed ID: 9259288
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Germline mutations in PTEN are present in Bannayan-Zonana syndrome.
Marsh DJ, Dahia PL, Zheng Z, Liaw D, Parsons R, Gorlin RJ, Eng C
Nat Genet. 1997
PubMed ID: 9241266
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TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.
Li DM, Sun H
Cancer Res. 1997
PubMed ID: 9187108
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Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome.
Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, Bose S, Call KM, Tsou HC, Peacocke M, Eng C, Parsons R
Nat Genet. 1997
PubMed ID: 9140396
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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.
Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH, Tavtigian SV
Nat Genet. 1997
PubMed ID: 9090379
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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R
Science. 1997
PubMed ID: 9072974
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Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
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Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers.
Peiffer SL, Herzog TJ, Tribune DJ, Mutch DG, Gersell DJ, Goodfellow PJ
Cancer Res. 1995
PubMed ID: 7728760
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Human Ia antigens--purification and molecular structure.
Snary D, Barnstable C, Bodmer WF, Goodfellow P, Crumpton MJ
Cold Spring Harb Symp Quant Biol. 1977
PubMed ID: 70315
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