Home VANGL2
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(Human) GRCh37 - chr1:160370231..160398468 (28.24 kb) View in Genome Browser
(Mouse) NCBIM37 - chr1:173931091..173958575 (27.48 kb) View in Genome Browser
(Rat) RGSC3.4 - chr13:87964426..87988364 (23.94 kb) View in Genome Browser
HaemAtlas Expression Table for VANGL2:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
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Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for VANGL2:The VANGL2 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| VANGL2 | DVL1 | HPRD, IntAct | empirical | 12490194 15456783 |
| VANGL2 | DVL2 | IntAct, BioGRID | empirical | 15456783 16571627 16116426 |
| VANGL2 | DVL3 | IntAct, BioGRID | empirical | 15456783 19008950 |
| VANGL2 | MAGI3 | HPRD | empirical | 15195140 |
| VANGL2 | SFRP2 | BioGRID | empirical | 18257070 |
| VANGL2 | UBC | BioGRID | empirical | 21139048 |
| VANGL2 | YWHAG | IntAct | empirical | 17353931 |
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Type 1 Diabetes Publications: 1
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Sequence and expression analysis of Nhlh1: a basic helix-loop-helix gene implicated in neurogenesis.
Murdoch JN, Eddleston J, Leblond-Bourget N, Stanier P, Copp AJ
Dev Genet. 1999
PubMed ID: 10079519
Publications: 146
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PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube.
Heydeck W, Liu A
Dev Dyn. 2011
PubMed ID: 21761479
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Mitotic internalization of planar cell polarity proteins preserves tissue polarity.
Devenport D, Oristian D, Heller E, Fuchs E
Nat Cell Biol. 2011
PubMed ID: 21743464
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Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape.
Tang N, Marshall WF, McMahon M, Metzger RJ, Martin GR
Science. 2011
PubMed ID: 21764747
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Focusing forward genetics: a tripartite ENU screen for neurodevelopmental mutations in the mouse.
Stottmann RW, Moran JL, Turbe-Doan A, Driver E, Kelley M, Beier DR
Genetics. 2011
PubMed ID: 21515572
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Contribution of VANGL2 mutations to isolated neural tube defects.
Kibar Z, Salem S, Bosoi CM, Pauwels E, De Marco P, Merello E, Bassuk AG, Capra V, Gros P
Clin Genet. 2011
PubMed ID: 20738329
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A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
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A novel hypomorphic Looptail allele at the planar cell polarity Vangl2 gene.
Guyot MC, Bosoi CM, Kharfallah F, Reynolds A, Drapeau P, Justice M, Gros P, Kibar Z
Dev Dyn. 2011
PubMed ID: 21404367
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Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development.
Armstrong A, Ryu YK, Chieco D, Kuruvilla R
J Neurosci. 2011
PubMed ID: 21325504
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Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance.
Shafer B, Onishi K, Lo C, Colakoglu G, Zou Y
Dev Cell. 2011
PubMed ID: 21316586
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Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2.
Gao B, Song H, Bishop K, Elliot G, Garrett L, English MA, Andre P, Robinson J, Sood R, Minami Y, Economides AN, Yang Y
Dev Cell. 2011
PubMed ID: 21316585
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Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity.
Li S, Esterberg R, Lachance V, Ren D, Radde-Gallwitz K, Chi F, Parent JL, Fritz A, Chen P
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21262816
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Loss of membrane targeting of Vangl proteins causes neural tube defects.
Iliescu A, Gravel M, Horth C, Kibar Z, Gros P
Biochemistry. 2011
PubMed ID: 21142127
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Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.
Dawe CE, Kooistra MK, Fairbridge NA, Pisio AC, McDermid HE
Dev Dyn. 2011
PubMed ID: 21246654
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Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney.
Perälä N, Jakobson M, Ola R, Fazzari P, Penachioni JY, Nymark M, Tanninen T, Immonen T, Tamagnone L, Sariola H
Differentiation. 2011
PubMed ID: 21035938
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Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes.
Babayeva S, Zilber Y, Torban E
Am J Physiol Renal Physiol. 2011
PubMed ID: 20534871
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Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B.
Wang B, Sinha T, Jiao K, Serra R, Wang J
Hum Mol Genet. 2011
PubMed ID: 20962035
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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When whorls collide: the development of hair patterns in frizzled 6 mutant mice.
Wang Y, Chang H, Nathans J
Development. 2010
PubMed ID: 21062866
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The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation.
Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH
Hum Mol Genet. 2010
PubMed ID: 20843830
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Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem.
Fenstermaker AG, Prasad AA, Bechara A, Adolfs Y, Tissir F, Goffinet A, Zou Y, Pasterkamp RJ
J Neurosci. 2010
PubMed ID: 21106844
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Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.
Yu H, Smallwood PM, Wang Y, Vidaltamayo R, Reed R, Nathans J
Development. 2010
PubMed ID: 20940229
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Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling.
Rocha PP, Scholze M, Bleiss W, Schrewe H
Development. 2010
PubMed ID: 20630950
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Epidermal wound repair is regulated by the planar cell polarity signaling pathway.
Caddy J, Wilanowski T, Darido C, Dworkin S, Ting SB, Zhao Q, Rank G, Auden A, Srivastava S, Papenfuss TA, Murdoch JN, Humbert PO, Parekh V, Boulos N, Weber T, Zuo J, Cunningham JM, Jane SM
Dev Cell. 2010
PubMed ID: 20643356
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Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning.
Song H, Hu J, Chen W, Elliott G, Andre P, Gao B, Yang Y
Nature. 2010
PubMed ID: 20562861
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VANGL2 mutations in human cranial neural-tube defects.
Lei YP, Zhang T, Li H, Wu BL, Jin L, Wang HY
N Engl J Med. 2010
PubMed ID: 20558380
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Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.
Tissir F, Qu Y, Montcouquiol M, Zhou L, Komatsu K, Shi D, Fujimori T, Labeau J, Tyteca D, Courtoy P, Poumay Y, Uemura T, Goffinet AM
Nat Neurosci. 2010
PubMed ID: 20473291
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The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis.
Yates LL, Schnatwinkel C, Murdoch JN, Bogani D, Formstone CJ, Townsend S, Greenfield A, Niswander LA, Dean CH
Hum Mol Genet. 2010
PubMed ID: 20223754
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Molecular and cellular mechanisms underlying neural tube defects in the loop-tail mutant mouse.
Gravel M, Iliescu A, Horth C, Apuzzo S, Gros P
Biochemistry. 2010
PubMed ID: 20329788
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Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b.
Wansleeben C, Feitsma H, Montcouquiol M, Kroon C, Cuppen E, Meijlink F
Development. 2010
PubMed ID: 20215345
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Epicardial-myocardial signaling directing coronary vasculogenesis.
Olivey HE, Svensson EC
Circ Res. 2010
PubMed ID: 20299672
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Vang-like protein 2 and Rac1 interact to regulate adherens junctions.
Lindqvist M, Horn Z, Bryja V, Schulte G, Papachristou P, Ajima R, Dyberg C, Arenas E, Yamaguchi TP, Lagercrantz H, Ringstedt T
J Cell Sci. 2010
PubMed ID: 20067994
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The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.
Paudyal A, Damrau C, Patterson VL, Ermakov A, Formstone C, Lalanne Z, Wells S, Lu X, Norris DP, Dean CH, Henderson DJ, Murdoch JN
BMC Dev Biol. 2010
PubMed ID: 20704721
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Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis.
Antic D, Stubbs JL, Suyama K, Kintner C, Scott MP, Axelrod JD
PLoS One. 2010
PubMed ID: 20126399
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Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure.
Merte J, Jensen D, Wright K, Sarsfield S, Wang Y, Schekman R, Ginty DD
Nat Cell Biol. 2010
PubMed ID: 19966784
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The planar cell polarity protein Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion.
Cantrell VA, Jessen JR
Cancer Lett. 2010
PubMed ID: 19577357
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The small GTPase Rac1 regulates auditory hair cell morphogenesis.
Grimsley-Myers CM, Sipe CW, Géléoc GS, Lu X
J Neurosci. 2009
PubMed ID: 20016102
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Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins.
Ahrens MJ, Li Y, Jiang H, Dudley AT
Development. 2009
PubMed ID: 19762422
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A Genome-wide Study of Common SNPs and CNVs in Cognitive Performance in the CANTAB battery.
Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KL, Hunt P, Ge D, Heinzen EL, Maia JM, Shianna KV, Weale ME, Cherkas LF, Clement G, Spector TD, Gibson G, Goldstein DB
Hum Mol Genet. 2009
PubMed ID: 19734545
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Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak.
Suriben R, Kivimäe S, Fisher DA, Moon RT, Cheyette BN
Nat Genet. 2009
PubMed ID: 19701191
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Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity.
Tao H, Suzuki M, Kiyonari H, Abe T, Sasaoka T, Ueno N
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19706528
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Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells.
Le Grand F, Jones AE, Seale V, Scimè A, Rudnicki MA
Cell Stem Cell. 2009
PubMed ID: 19497282
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2.
Vandenberg AL, Sassoon DA
Development. 2009
PubMed ID: 19363157
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Strabismus regulates asymmetric cell divisions and cell fate determination in the mouse brain.
Lake BB, Sokol SY
J Cell Biol. 2009
PubMed ID: 19332887
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Motor neurons with axial muscle projections specified by Wnt4/5 signaling.
Agalliu D, Takada S, Agalliu I, McMahon AP, Jessell TM
Neuron. 2009
PubMed ID: 19285468
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Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium.
Matsuyama M, Aizawa S, Shimono A
PLoS Genet. 2009
PubMed ID: 19300477
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Wnt5a is essential for intestinal elongation in mice.
Cervantes S, Yamaguchi TP, Hebrok M
Dev Biol. 2009
PubMed ID: 19100728
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Sfrp1 and Sfrp2 are required for normal male sexual development in mice.
Warr N, Siggers P, Bogani D, Brixey R, Pastorelli L, Yates L, Dean CH, Wells S, Satoh W, Shimono A, Greenfield A
Dev Biol. 2009
PubMed ID: 19100252
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Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases.
Vivancos V, Chen P, Spassky N, Qian D, Dabdoub A, Kelley M, Studer M, Guthrie S
Neural Dev. 2009
PubMed ID: 19210786
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Effects of Retinoic Acid on the Expressions of Vangl1 and Vangl2 in Mouse Fetuses.
Liu J, Qi J, Zhu J, Zhang L, Liang Y, Ning Q, Luo X
J Neurogenet. 2008
PubMed ID: 19012162
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Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.
Etheridge SL, Ray S, Li S, Hamblet NS, Lijam N, Tsang M, Greer J, Kardos N, Wang J, Sussman DJ, Chen P, Wynshaw-Boris A
PLoS Genet. 2008
PubMed ID: 19008950
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Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles.
Devenport D, Fuchs E
Nat Cell Biol. 2008
PubMed ID: 18849982
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Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
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Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo.
García-García MJ, Shibata M, Anderson KV
Development. 2008
PubMed ID: 18701545
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Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice.
Yang Z, Chen Y, Lillo C, Chien J, Yu Z, Michaelides M, Klein M, Howes KA, Li Y, Kaminoh Y, Chen H, Zhao C, Chen Y, Al-Sheikh YT, Karan G, Corbeil D, Escher P, Kamaya S, Li C, Johnson S, Frederick JM, Zhao Y, Wang C, Cameron DJ, Huttner WB, Schorderet DF, Munier FL, Moore AT, Birch DG, Baehr W, Hunt DM, Williams DS, Zhang K
J Clin Invest. 2008
PubMed ID: 18654668
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Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease.
Saburi S, Hester I, Fischer E, Pontoglio M, Eremina V, Gessler M, Quaggin SE, Harrison R, Mount R, McNeill H
Nat Genet. 2008
PubMed ID: 18604206
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Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.
Yamamoto S, Nishimura O, Misaki K, Nishita M, Minami Y, Yonemura S, Tarui H, Sasaki H
Dev Cell. 2008
PubMed ID: 18606138
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A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth.
Lefèvre G, Michel V, Weil D, Lepelletier L, Bizard E, Wolfrum U, Hardelin JP, Petit C
Development. 2008
PubMed ID: 18339676
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GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
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Non-cell-autonomous roles for the planar cell polarity gene Vangl2 in development of the coronary circulation.
Phillips HM, Hildreth V, Peat JD, Murdoch JN, Kobayashi K, Chaudhry B, Henderson DJ
Circ Res. 2008
PubMed ID: 18174466
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Genetic interaction between members of the Vangl family causes neural tube defects in mice.
Torban E, Patenaude AM, Leclerc S, Rakowiecki S, Gauthier S, Andelfinger G, Epstein DJ, Gros P
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18296642
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Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse.
Satoh W, Matsuyama M, Takemura H, Aizawa S, Shimono A
Genesis. 2008
PubMed ID: 18257070
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Ciliary proteins link basal body polarization to planar cell polarity regulation.
Jones C, Roper VC, Foucher I, Qian D, Banizs B, Petit C, Yoder BK, Chen P
Nat Genet. 2008
PubMed ID: 18066062
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Mutation analysis of the Vangl2 coding region revealed no common cause for Tetralogy of Fallot.
Erdal E, Erdal C, Bulut G, Kunter I, Kir M, Atabey N, Açikel U
J Int Med Res. 2007
PubMed ID: 18034999
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Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2.
Zhou W, Lin L, Majumdar A, Li X, Zhang X, Liu W, Etheridge L, Shi Y, Martin J, Van de Ven W, Kaartinen V, Wynshaw-Boris A, McMahon AP, Rosenfeld MG, Evans SM
Nat Genet. 2007
PubMed ID: 17767158
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EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
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Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization.
Phillips HM, Rhee HJ, Murdoch JN, Hildreth V, Peat JD, Anderson RH, Copp AJ, Chaudhry B, Henderson DJ
Circ Res. 2007
PubMed ID: 17556662
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In utero topographic analysis of astrocytes and neuronal cells in the spinal cord of mutant mice with myelomeningocele.
Reis JL, Correia-Pinto J, Monteiro MP, Hutchins GM
J Neurosurg. 2007
PubMed ID: 17566405
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Wnt5a functions in planar cell polarity regulation in mice.
Qian D, Jones C, Rzadzinska A, Mark S, Zhang X, Steel KP, Dai X, Chen P
Dev Biol. 2007
PubMed ID: 17433286
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Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear.
Deans MR, Antic D, Suyama K, Scott MP, Axelrod JD, Goodrich LV
J Neurosci. 2007
PubMed ID: 17376975
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Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure.
Ybot-Gonzalez P, Savery D, Gerrelli D, Signore M, Mitchell CE, Faux CH, Greene ND, Copp AJ
Development. 2007
PubMed ID: 17229766
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Planar cell polarity signaling in vertebrates.
Jones C, Chen P
Bioessays. 2007
PubMed ID: 17226800
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Wnt7a overexpression delays beta-tubulin III expression in transgenic mouse embryos.
Horn Z, Papachristou P, Shariatmadari M, Peyronnet J, Eriksson B, Ringstedt T
Brain Res. 2007
PubMed ID: 17174942
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Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation.
Torban E, Wang HJ, Patenaude AM, Riccomagno M, Daniels E, Epstein D, Gros P
Gene Expr Patterns. 2007
PubMed ID: 16962386
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T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration.
Song MR, Shirasaki R, Cai CL, Ruiz EC, Evans SM, Lee SK, Pfaff SL
Development. 2006
PubMed ID: 17119020
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The DNA sequence and biological annotation of human chromosome 1.
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Development. 2006
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Eur J Neurosci. 2006
PubMed ID: 16487141
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J Neurochem. 2005
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Science. 2005
PubMed ID: 16141073
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Science. 2005
PubMed ID: 16141072
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Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway.
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Nat Genet. 2005
PubMed ID: 16116426
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Expression pattern of glypican-4 suggests multiple roles during mouse development.
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Dev Dyn. 2005
PubMed ID: 15830372
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Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract.
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Circ Res. 2005
PubMed ID: 15637299
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Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.
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J Biol Chem. 2004
PubMed ID: 15456783
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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Genome Res. 2004
PubMed ID: 15489334
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Oncogene. 2004
PubMed ID: 15195140
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PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates.
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Nature. 2004
PubMed ID: 15229603
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Nature. 2004
PubMed ID: 15057822
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
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Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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Cordon-bleu is a conserved gene involved in neural tube formation.
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Dev Biol. 2003
PubMed ID: 14512015
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Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
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DNA Res. 2003
PubMed ID: 14621295
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Identification of Vangl2 and Scrb1 as planar polarity genes in mammals.
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Nature. 2003
PubMed ID: 12724779
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Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse.
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Hum Mol Genet. 2003
PubMed ID: 12499390
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Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction.
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Dev Biol. 2003
PubMed ID: 12490194
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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Nature. 2002
PubMed ID: 12466851
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PubMed ID: 12466850
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Structure and expression of Strabismus 1 gene on human chromosome 1q21-q23.
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PubMed ID: 12011999
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A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
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Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop-tail mutation.
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Genomics. 2001
PubMed ID: 11707073
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Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification.
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Hum Mol Genet. 2001
PubMed ID: 11709546
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Cardiovascular defects associated with abnormalities in midline development in the Loop-tail mouse mutant.
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Circ Res. 2001
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Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.
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Nat Genet. 2001
PubMed ID: 11431695
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Identification of a new chemically induced allele (Lp(m1Jus)) at the loop-tail locus: morphology, histology, and genetic mapping.
Kibar Z, Underhill DA, Canonne-Hergaux F, Gauthier S, Justice MJ, Gros P
Genomics. 2001
PubMed ID: 11401449
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Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23.
Doudney K, Murdoch JN, Paternotte C, Bentley L, Gregory S, Copp AJ, Stanier P
Genomics. 2001
PubMed ID: 11401431
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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Mini-review: toward understanding mechanisms of genetic neural tube defects in mice.
Harris MJ, Juriloff DM
Teratology. 1999
PubMed ID: 10525207
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Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O
DNA Res. 1999
PubMed ID: 10574462
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A QTL for the genetic variance in free-running period and level of locomotor activity between inbred strains of mice.
Mayeda AR, Hofstetter JR
Behav Genet. 1999
PubMed ID: 10547923
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Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp).
Eddleston J, Murdoch JN, Copp AJ, Stanier P
Genomics. 1999
PubMed ID: 10051400
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Physical delineation of a 700-kb region overlapping the Looptail mutation on mouse chromosome 1.
Underhill DA, Mullick A, Groulx N, Beatty BG, Gros P
Genomics. 1999
PubMed ID: 9933565
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects.
Greene ND, Gerrelli D, Van Straaten HW, Copp AJ
Mech Dev. 1998
PubMed ID: 9545534
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Strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila.
Wolff T, Rubin GM
Development. 1998
PubMed ID: 9463361
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Failure of neural tube closure in the loop-tail (Lp) mutant mouse: analysis of the embryonic mechanism.
Gerrelli D, Copp AJ
Brain Res Dev Brain Res. 1997
PubMed ID: 9352104
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Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
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Alterations in cranial morphogenesis in the Lp mutant mouse.
Wilson DB, Wyatt DP
J Craniofac Genet Dev Biol. 1995
PubMed ID: 8719347
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Nhlh1, a basic helix-loop-helix transcription factor, is very tightly linked to the mouse looptail (Lp) mutation.
Mullick A, Groulx N, Trasler D, Gros P
Mamm Genome. 1995
PubMed ID: 8563167
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High-resolution linkage map in the vicinity of the Lp locus.
Mullick A, Trasler D, Gros P
Genomics. 1995
PubMed ID: 7607671
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Genetic basis of neural tube defects: the mouse gene loop-tail maps to a region of chromosome 1 syntenic with human 1q21-q23.
Stanier P, Henson JN, Eddleston J, Moore GE, Copp AJ
Genomics. 1995
PubMed ID: 7607670
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Developmental basis of severe neural tube defects in the loop-tail (Lp) mutant mouse: use of microsatellite DNA markers to identify embryonic genotype.
Copp AJ, Checiu I, Henson JN
Dev Biol. 1994
PubMed ID: 8088438
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Analysis of neurulation in a mouse model for neural dysraphism.
Wilson DB, Wyatt DP
Exp Neurol. 1994
PubMed ID: 8200433
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Abnormal elevation of the neural folds in the loop-tail mutant mouse.
Wilson DB, Wyatt DP
Acta Anat (Basel). 1992
PubMed ID: 1598821
-
An ultrastructural analysis of abnormal otic development in exencephalic mutant mice.
Wilson DB
Arch Otorhinolaryngol. 1985
PubMed ID: 3977771
-
Ultrastructural analysis of basal neuroepithelial cells in dysraphic mice.
Wilson DB
Virchows Arch B Cell Pathol Incl Mol Pathol. 1985
PubMed ID: 2858942
-
A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice.
Roths JB, Murphy ED, Eicher EM
J Exp Med. 1984
PubMed ID: 6693832
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Early development of the otocyst in an exencephalic mutant of the mouse.
Wilson DB
Acta Anat (Basel). 1983
PubMed ID: 6650116
-
Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains.
Kozak CA, Rowe WP
J Exp Med. 1980
PubMed ID: 6249881
-
Early development of the brain and spinal cord in dysraphic mice: a transmission electron microscopic study.
Wilson DB, Finta LA
J Comp Neurol. 1980
PubMed ID: 6991554
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Genetic variation in alkaline phosphatase of the house mouse (Mus musculus) with emphasis on a manganese-requiring isozyme.
Wilcox FH, Hirschhorn L, Taylor BA, Womack JE, Roderick TH
Biochem Genet. 1979
PubMed ID: 540002
-
Linkage of the locus for conversion of albumin (Acf-1) in the house mouse, Mus musculus.
Wilcox FH, Womack JE, Roderick TH
Biochem Genet. 1979
PubMed ID: 454356
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Differences in cerebral morphology in 2 stocks of mutant mice heterozygous for the loop-tail (Lp)-gene.
Wilson DB, Center EM
Experientia. 1977
PubMed ID: 923728
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Surface defects in ventricular cells of brains of mouse embryos homozygous for the Loop-tail gene: scanning electron microscopic study.
Wilson DB, Michael SD
Teratology. 1975
PubMed ID: 1138408
-
The neural cell cycle in the looptail (Lp) mutant mouse.
Wilson DB, Center EM
J Embryol Exp Morphol. 1974
PubMed ID: 4477997
-
Enlarged ventricles in the cerebrum of loop-tail mice.
van Abeelen JH, Raven SM
Experientia. 1968
PubMed ID: 4230658
-
Behavioural ontogeny of looptail mice.
van Abeelen JH
Anim Behav. 1968
PubMed ID: 5651230
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Influence of the neural tube on the differentiation of the inner ear in the mammalian embryo.
Deol MS
Nature. 1966
PubMed ID: 5912439
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Behavioural profiles of neurological mutant mice.
van Abeelen JH
Genetica. 1966
PubMed ID: 5955164
-
Axial elongation in the mouse and its retardation in homozygous looptail mice.
SMITH LJ, STEIN KF
J Embryol Exp Morphol. 1962
PubMed ID: 14039372
-
Abnormal development of the thoracic skeleton in mice homozygous for the gene for looped-tail.
STEIN KF, MACKENSEN JA
Am J Anat. 1957
PubMed ID: 13435227
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