Home PSME2
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(Human) GRCh37 - chr14:24612574..24616779 (4.21 kb) View in Genome Browser
(Mouse) NCBIM37 - chr14:56206277..56209950 (3.67 kb) View in Genome Browser
(Rat) RGSC3.4 - chr15:33722370..33726669 (4.30 kb) View in Genome Browser
HaemAtlas Expression Table for PSME2:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for PSME2:The PSME2 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| PSME2 | PSME3 | Reactome | predicted | |
| PSME2 | PSMD14 | Reactome | predicted | |
| PSME2 | CFTR | IntAct | empirical | 17110338 |
| PSME2 | PSMB11 | Reactome | predicted | |
| PSME2 | PSMA8 | Reactome | predicted | |
| PSME2 | EPHA2 | IntAct | empirical | 21988832 |
| PSME2 | PSME4 | Reactome | predicted | |
| PSME2 | MGMT | BioGRID | empirical | 16226712 |
| PSME2 | MYOD1 | IntAct | empirical | 21988832 |
| PSME2 | NHLH1 | IntAct | empirical | 21988832 |
| PSME2 | PSMA1 | Reactome | predicted | |
| PSME2 | PSMA2 | Reactome | predicted | |
| PSME2 | PSMA3 | Reactome | predicted | |
| PSME2 | PSMA4 | Reactome | predicted | |
| PSME2 | PSMA5 | Reactome | predicted | |
| PSME2 | PSMA6 | Reactome | predicted | |
| PSME2 | PSMA7 | Reactome | predicted | |
| PSME2 | PSMB1 | Reactome | predicted | |
| PSME2 | PSMB2 | Reactome | predicted | |
| PSME2 | PSMB3 | Reactome | predicted | |
| PSME2 | PSMB4 | Reactome | predicted | |
| PSME2 | PSMB5 | Reactome | predicted | |
| PSME2 | PSMB6 | Reactome | predicted | |
| PSME2 | PSMB7 | Reactome | predicted | |
| PSME2 | PSMB8 | Reactome | predicted | |
| PSME2 | PSMB9 | Reactome | predicted | |
| PSME2 | PSMB10 | Reactome | predicted | |
| PSME2 | PSMC1 | Reactome | predicted | |
| PSME2 | PSMC2 | Reactome | predicted | |
| PSME2 | PSMC3 | Reactome | predicted | |
| PSME2 | PSMC4 | Reactome | predicted | |
| PSME2 | PSMC5 | Reactome | predicted | |
| PSME2 | PSMC6 | Reactome | predicted | |
| PSME2 | PSMD1 | Reactome | predicted | |
| PSME2 | PSMD2 | Reactome | predicted | |
| PSME2 | PSMD3 | Reactome | predicted | |
| PSME2 | PSMD4 | Reactome | predicted | |
| PSME2 | PSMD5 | Reactome | predicted | |
| PSME2 | PSMD7 | Reactome | predicted | |
| PSME2 | PSMD8 | Reactome | predicted | |
| PSME2 | PSMD9 | Reactome | predicted | |
| PSME2 | PSMD10 | Reactome | predicted | |
| PSME2 | PSMD11 | Reactome | predicted | |
| PSME2 | PSMD12 | Reactome | predicted | |
| PSME2 | PSMD13 | Reactome | predicted | |
| PSME2 | PSME1 | HPRD, MINT, IntAct, BioGRID, Reactome | empirical | 8663520 16189514 |
| PSME2 | PSME2 | HPRD, MINT, IntAct, BioGRID | empirical | 16189514 |
| PSME2 | UBC | BioGRID | empirical | 21987572 21139048 21890473 21906983 |
| PSME2 | PSMF1 | Reactome | predicted | |
| PSME2 | IKBKE | IntAct | empirical | 17353931 |
| PSME2 | PSMD6 | Reactome | predicted |
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Type 1 Diabetes Publications: 1
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Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta.
Murata S, Udono H, Tanahashi N, Hamada N, Watanabe K, Adachi K, Yamano T, Yui K, Kobayashi N, Kasahara M, Tanaka K, Chiba T
EMBO J. 2001
PubMed ID: 11689430
Publications: 80
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Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
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PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo.
de Graaf N, van Helden MJ, Textoris-Taube K, Chiba T, Topham DJ, Kloetzel PM, Zaiss DM, Sijts AJ
Eur J Immunol. 2011
PubMed ID: 21360704
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Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
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Allele-selective effect of PA28 in MHC class I antigen processing.
Yamano T, Sugahara H, Mizukami S, Murata S, Chiba T, Tanaka K, Yui K, Udono H
J Immunol. 2008
PubMed ID: 18641301
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Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.
Wang X, Chen CF, Baker PR, Chen PL, Kaiser P, Huang L
Biochemistry. 2007
PubMed ID: 17323924
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The ubiquitin-proteasome system plays essential roles in presenting an 8-mer CTL epitope expressed in APC to corresponding CD8+ T cells.
Duan X, Hisaeda H, Shen J, Tu L, Imai T, Chou B, Murata S, Chiba T, Tanaka K, Fehling HJ, Koga T, Sueishi K, Himeno K
Int Immunol. 2006
PubMed ID: 16569681
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Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.
Niture SK, Doneanu CE, Velu CS, Bailey NI, Srivenugopal KS
Biochem Biophys Res Commun. 2005
PubMed ID: 16226712
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Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells.
Ossendorp F, Fu N, Camps M, Granucci F, Gobin SJ, van den Elsen PJ, Schuurhuis D, Adema GJ, Lipford GB, Chiba T, Sijts A, Kloetzel PM, Ricciardi-Castagnoli P, Melief CJ
J Immunol. 2005
PubMed ID: 15944286
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus.
Basler M, Youhnovski N, Van Den Broek M, Przybylski M, Groettrup M
J Immunol. 2004
PubMed ID: 15356141
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Mammalian Cdh1/Fzr mediates its own degradation.
Listovsky T, Oren YS, Yudkovsky Y, Mahbubani HM, Weiss AM, Lebendiker M, Brandeis M
EMBO J. 2004
PubMed ID: 15029244
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G.
Conticello SG, Harris RS, Neuberger MS
Curr Biol. 2003
PubMed ID: 14614829
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Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex.
Yu X, Yu Y, Liu B, Luo K, Kong W, Mao P, Yu XF
Science. 2003
PubMed ID: 14564014
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The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity.
Shindo K, Takaori-Kondo A, Kobayashi M, Abudu A, Fukunaga K, Uchiyama T
J Biol Chem. 2003
PubMed ID: 12970355
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The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity.
Kao S, Khan MA, Miyagi E, Plishka R, Buckler-White A, Strebel K
J Virol. 2003
PubMed ID: 14557625
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HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation.
Marin M, Rose KM, Kozak SL, Kabat D
Nat Med. 2003
PubMed ID: 14528301
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The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif.
Sheehy AM, Gaddis NC, Malim MH
Nat Med. 2003
PubMed ID: 14528300
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Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.
Apcher GS, Heink S, Zantopf D, Kloetzel PM, Schmid HP, Mayer RJ, Krüger E
FEBS Lett. 2003
PubMed ID: 14550573
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HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability.
Stopak K, de Noronha C, Yonemoto W, Greene WC
Mol Cell. 2003
PubMed ID: 14527406
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Virology. Weapons of mutational destruction.
KewalRamani VN, Coffin JM
Science. 2003
PubMed ID: 12920286
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Death by deamination: a novel host restriction system for HIV-1.
Goff SP
Cell. 2003
PubMed ID: 12914693
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Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.
Mariani R, Chen D, Schröfelbauer B, Navarro F, König R, Bollman B, Münk C, Nymark-McMahon H, Landau NR
Cell. 2003
PubMed ID: 12859895
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Good to CU.
Gu Y, Sundquist WI
Nature. 2003
PubMed ID: 12840737
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Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts.
Mangeat B, Turelli P, Caron G, Friedli M, Perrin L, Trono D
Nature. 2003
PubMed ID: 12808466
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The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA.
Zhang H, Yang B, Pomerantz RJ, Zhang C, Arunachalam SC, Gao L
Nature. 2003
PubMed ID: 12808465
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DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses.
Harris RS, Sheehy AM, Craig HM, Malim MH, Neuberger MS
Nat Immunol. 2003
PubMed ID: 12830140
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DNA deamination mediates innate immunity to retroviral infection.
Harris RS, Bishop KN, Sheehy AM, Craig HM, Petersen-Mahrt SK, Watt IN, Neuberger MS, Malim MH
Cell. 2003
PubMed ID: 12809610
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Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.
Margottin-Goguet F, Hsu JY, Loktev A, Hsieh HM, Reimann JD, Jackson PK
Dev Cell. 2003
PubMed ID: 12791267
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Hypermutation of HIV-1 DNA in the absence of the Vif protein.
Lecossier D, Bouchonnet F, Clavel F, Hance AJ
Science. 2003
PubMed ID: 12750511
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Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions.
Gaddis NC, Chertova E, Sheehy AM, Henderson LE, Malim MH
J Virol. 2003
PubMed ID: 12719574
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The DNA sequence and analysis of human chromosome 14.
Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Brüls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Ségurens B, Anière F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Ménard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufossé-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guérin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quétier F, Waterston R, Hood L, Weissenbach J
Nature. 2003
PubMed ID: 12508121
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Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells.
Miyagi T, Tatsumi T, Takehara T, Kanto T, Kuzushita N, Sugimoto Y, Jinushi M, Kasahara A, Sasaki Y, Hori M, Hayashi N
J Gastroenterol Hepatol. 2003
PubMed ID: 12519221
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing.
Huang X, Seifert U, Salzmann U, Henklein P, Preissner R, Henke W, Sijts AJ, Kloetzel PM, Dubiel W
J Mol Biol. 2002
PubMed ID: 12419264
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The role of the proteasome activator PA28 in MHC class I antigen processing.
Sijts A, Sun Y, Janek K, Kral S, Paschen A, Schadendorf D, Kloetzel PM
Mol Immunol. 2002
PubMed ID: 12200048
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Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.
Sheehy AM, Gaddis NC, Choi JD, Malim MH
Nature. 2002
PubMed ID: 12167863
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Two distinct pathways mediated by PA28 and hsp90 in major histocompatibility complex class I antigen processing.
Yamano T, Murata S, Shimbara N, Tanaka N, Chiba T, Tanaka K, Yui K, Udono H
J Exp Med. 2002
PubMed ID: 12119343
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A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD
Science. 2002
PubMed ID: 12040188
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The mouse Supt16h/Fact140 gene, encoding part of the FACT chromatin transcription complex, maps close to Tcra and is highly expressed in thymus.
McGuire MV, Suthipinijtham P, Gascoigne NR
Mamm Genome. 2001
PubMed ID: 11471063
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Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.
Geley S, Kramer E, Gieffers C, Gannon J, Peters JM, Hunt T
J Cell Biol. 2001
PubMed ID: 11285280
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Nucleotide sequence analysis of the approximately 35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes.
Yawata M, Murata S, Tanaka K, Ishigatsubo Y, Kasahara M
Immunogenetics. 2001
PubMed ID: 11345588
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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Degradation of HIV-1 integrase by the N-end rule pathway.
Mulder LC, Muesing MA
J Biol Chem. 2000
PubMed ID: 10893419
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Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis.
Tanahashi N, Murakami Y, Minami Y, Shimbara N, Hendil KB, Tanaka K
J Biol Chem. 2000
PubMed ID: 10799514
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Impaired immunoproteasome assembly and immune responses in PA28-/- mice.
Preckel T, Fung-Leung WP, Cai Z, Vitiello A, Salter-Cid L, Winqvist O, Wolfe TG, Von Herrath M, Angulo A, Ghazal P, Lee JD, Fourie AM, Wu Y, Pang J, Ngo K, Peterson PA, Früh K, Yang Y
Science. 1999
PubMed ID: 10591649
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Structural and functional characterizations of the proteasome-activating protein PA26 from Trypanosoma brucei.
Yao Y, Huang L, Krutchinsky A, Wong ML, Standing KG, Burlingame AL, Wang CC
J Biol Chem. 1999
PubMed ID: 10567354
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Organization of the genes encoding the human proteasome activators PA28alpha and beta.
McCusker D, Wilson M, Trowsdale J
Immunogenetics. 1999
PubMed ID: 10199920
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A second gene encoding the mouse proteasome activator PA28beta subunit is part of a LINE1 element and is driven by a LINE1 promoter.
Zaiss DM, Kloetzel PM
J Mol Biol. 1999
PubMed ID: 10222192
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Characterization of the mouse proteasome regulator PA28b gene.
Li Y, Chambers J, Pang J, Ngo K, Peterson PA, Leung WP, Yang Y
Immunogenetics. 1999
PubMed ID: 9914329
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Antigen presentation by MHC class I and its regulation by interferon gamma.
Früh K, Yang Y
Curr Opin Immunol. 1999
PubMed ID: 10047537
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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Evidence for a newly discovered cellular anti-HIV-1 phenotype.
Simon JH, Gaddis NC, Fouchier RA, Malim MH
Nat Med. 1998
PubMed ID: 9846577
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An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.
Madani N, Kabat D
J Virol. 1998
PubMed ID: 9811770
-
Proteasome activator (PA28) subunits, alpha, beta and gamma (Ki antigen) in NT2 neuronal precursor cells and HeLa S3 cells.
Wójcik C, Tanaka K, Paweletz N, Naab U, Wilk S
Eur J Cell Biol. 1998
PubMed ID: 9840465
-
Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes.
Hendil KB, Khan S, Tanaka K
Biochem J. 1998
PubMed ID: 9620878
-
Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes.
Kohda K, Ishibashi T, Shimbara N, Tanaka K, Matsuda Y, Kasahara M
J Immunol. 1998
PubMed ID: 9590240
-
Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
Gene. 1997
PubMed ID: 9373149
-
Genetic relationships of the genes encoding the human proteasome beta subunits and the proteasome PA28 complex.
McCusker D, Jones T, Sheer D, Trowsdale J
Genomics. 1997
PubMed ID: 9344661
-
Expression and subcellular localization of mouse 20S proteasome activator complex PA28.
Soza A, Knuehl C, Groettrup M, Henklein P, Tanaka K, Kloetzel PM
FEBS Lett. 1997
PubMed ID: 9287111
-
HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation.
Seeger M, Ferrell K, Frank R, Dubiel W
J Biol Chem. 1997
PubMed ID: 9079628
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Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit.
Kohda K, Matsuda Y, Ishibashi T, Tanaka K, Kasahara M
Immunogenetics. 1997
PubMed ID: 9382924
-
PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes.
Kandil E, Kohda K, Ishibashi T, Tanaka K, Kasahara M
Immunogenetics. 1997
PubMed ID: 9218537
-
Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki.
Jiang H, Monaco JJ
Immunogenetics. 1997
PubMed ID: 9162094
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In vivo characterization of the proteasome regulator PA28.
Ahn K, Erlander M, Leturcq D, Peterson PA, Früh K, Yang Y
J Biol Chem. 1996
PubMed ID: 8663520
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Structure and functions of the 20S and 26S proteasomes.
Coux O, Tanaka K, Goldberg AL
Annu Rev Biochem. 1996
PubMed ID: 8811196
-
Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome.
Ahn JY, Tanahashi N, Akiyama K, Hisamatsu H, Noda C, Tanaka K, Chung CH, Shibmara N, Willy PJ, Mott JD
FEBS Lett. 1995
PubMed ID: 7789512
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PA28, an activator of the 20 S proteasome, is composed of two nonidentical but homologous subunits.
Mott JD, Pramanik BC, Moomaw CR, Afendis SJ, DeMartino GN, Slaughter CA
J Biol Chem. 1994
PubMed ID: 7989312
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Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
PubMed ID: 8125298
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Purification of an 11 S regulator of the multicatalytic protease.
Dubiel W, Pratt G, Ferrell K, Rechsteiner M
J Biol Chem. 1992
PubMed ID: 1429590
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