PSMD10

Summary Top Help

Gene Description:

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

Synonyms:

p28Gank, p28, dJ889N15.2, PSMD10, AW554874, p28(GANK), Psmd10

Orthologs:

Human PSMD10 (protein-coding), Mouse Psmd10 (protein-coding), Rat Psmd10 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chrX:107327435..107334874 (7.44 kb) View in Genome Browser

(Mouse) NCBIM37 - chrX:137482964..137491267 (8.30 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PSMD10:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PSMD10:

The PSMD10 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
PSMD10	CDK4	HPRD	empirical	11779854
PSMD10	PSME3	Reactome	predicted
PSMD10	PSMD14	IntAct, BioGRID, Reactome, Sanger Interaction Map	empirical	19615732 19412159 15345047
PSMD10	PSMB11	Reactome	predicted
PSMD10	PSMA8	Reactome	predicted
PSMD10	PSME4	Reactome	predicted
PSMD10	PSAT1	IntAct	empirical	21988832
PSMD10	MAGEA4	HPRD, IntAct	empirical	12525503
PSMD10	MDM2	HPRD, BioGRID	empirical	16023600 18332869 17904523
PSMD10	NFKB1	BioGRID	empirical	17904523
PSMD10	UCHL5	IntAct, BioGRID	empirical	19490896 19615732
PSMD10	PSMA1	Reactome	predicted
PSMD10	PSMA2	Reactome	predicted
PSMD10	PSMA3	Reactome	predicted
PSMD10	PSMA4	Reactome	predicted
PSMD10	PSMA5	Reactome	predicted
PSMD10	PSMA6	Reactome	predicted
PSMD10	PSMA7	Reactome	predicted
PSMD10	PSMB1	Reactome	predicted
PSMD10	PSMB2	Reactome	predicted
PSMD10	PSMB3	Reactome	predicted
PSMD10	PSMB4	Reactome	predicted
PSMD10	PSMB5	Reactome	predicted
PSMD10	PSMB6	Reactome	predicted
PSMD10	PSMB7	Reactome	predicted
PSMD10	PSMB8	Reactome	predicted
PSMD10	PSMB9	Reactome	predicted
PSMD10	PSMB10	Reactome	predicted
PSMD10	PSMC1	IntAct, BioGRID, Reactome, Sanger Interaction Map	empirical	17353931 19490896 15345047
PSMD10	PSMC2	IntAct, Reactome, Sanger Interaction Map	empirical	17353931 19490896 15345047
PSMD10	PSMC3	IntAct, BioGRID, Reactome	empirical	17353931 19490896
PSMD10	PSMC4	HPRD, MINT, IntAct, BioGRID, Reactome, Sanger Interaction Map	empirical	11779854 16189514 17353931 12525503 19490896 21988832 19412159 15345047
PSMD10	PSMC5	IntAct, BioGRID, Reactome	empirical	17353931 19490896
PSMD10	PSMC6	IntAct, BioGRID, Reactome, Sanger Interaction Map	empirical	17353931 19490896 15345047
PSMD10	PSMD1	IntAct, Reactome	empirical	17353931 19490896
PSMD10	PSMD2	IntAct, Reactome	empirical	17353931
PSMD10	PSMD3	IntAct, BioGRID, Reactome	empirical	17353931
PSMD10	PSMD4	IntAct, BioGRID, Reactome, Sanger Interaction Map	empirical	17353931 15345047
PSMD10	PSMD5	Reactome	predicted
PSMD10	PSMD7	IntAct, Reactome, Sanger Interaction Map	empirical	17353931 19615732 15345047
PSMD10	PSMD8	Reactome	predicted
PSMD10	PSMD9	Reactome	predicted
PSMD10	PSMD11	IntAct, BioGRID, Reactome, Sanger Interaction Map	empirical	17353931 19490896 15345047
PSMD10	PSMD12	IntAct, BioGRID, Reactome	empirical	17353931 19490896
PSMD10	PSMD13	IntAct, Reactome, Sanger Interaction Map	empirical	19490896 15345047
PSMD10	PSME1	Reactome	predicted
PSMD10	PSME2	Reactome	predicted
PSMD10	RB1	HPRD, IntAct	empirical	10613832 12525503
PSMD10	RELA	BioGRID	empirical	17904523
PSMD10	ELOVL1	IntAct, BioGRID	empirical	17353931
PSMD10	TP53	BioGRID	empirical	16023600
PSMD10	UBC	BioGRID	empirical	16196087 22118674 21139048 21890473 21906983
PSMD10	PAAF1	IntAct, BioGRID	empirical	17353931 19490896
PSMD10	HIST1H2BC	BioGRID	empirical	17353931
PSMD10	LDB1	IntAct	empirical	21988832
PSMD10	DOK2	IntAct, BioGRID	empirical	17353931
PSMD10	USP14	IntAct, BioGRID	empirical	19615732
PSMD10	PSMF1	Reactome	predicted
PSMD10	PSMD6	IntAct, BioGRID, Reactome, Sanger Interaction Map	empirical	17353931 19490896 15345047

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: 47

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	REACT_6954
APC/C-mediated degradation of cell cycle proteins	REACT_6828
APC/C:Cdc20 mediated degradation of mitotic proteins	REACT_6781
APC/C:Cdc20 mediated degradation of Securin	REACT_6871
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	REACT_6761
Apoptosis	REACT_578
Assembly of the pre-replicative complex	REACT_2243
Autodegradation of Cdh1 by Cdh1:APC/C	REACT_6785
Autodegradation of the E3 ubiquitin ligase COP1	REACT_20549
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	REACT_6850
CDK-mediated phosphorylation and removal of Cdc6	REACT_1221
CDT1 association with the CDC6:ORC:origin complex	REACT_1949
Cell Cycle Checkpoints	REACT_1538
Cell Cycle, Mitotic	REACT_152
Cyclin A:Cdk2-associated events at S phase entry	REACT_9029
Cyclin E associated events during G1/S transition	REACT_1574
Degradation of beta-catenin by the destruction complex	REACT_11063
DNA Replication	REACT_383
DNA Replication Pre-Initiation	REACT_734
G1/S DNA Damage Checkpoints	REACT_2254
G1/S Transition	REACT_1783
M/G1 Transition	REACT_1725
Metabolism of amino acids and derivatives	REACT_13
Mitotic G1-G1/S phases	REACT_21267
Mitotic M-M/G1 phases	REACT_21300
Orc1 removal from chromatin	REACT_1156
p53-Dependent G1 DNA Damage Response	REACT_1625
p53-Dependent G1/S DNA damage checkpoint	REACT_85
p53-Independent DNA Damage Response	REACT_2160
p53-Independent G1/S DNA damage checkpoint	REACT_1208
Regulation of activated PAK-2p34 by proteasome mediated degradation	REACT_13464
Regulation of APC/C activators between G1/S and early anaphase	REACT_6837
Regulation of Apoptosis	REACT_13648
Regulation of DNA replication	REACT_829
Regulation of mitotic cell cycle	REACT_21279
Regulation of ornithine decarboxylase (ODC)	REACT_13565
Removal of licensing factors from origins	REACT_207
S Phase	REACT_899
SCF(Skp2)-mediated degradation of p27/p21	REACT_9003
SCF-beta-TrCP mediated degradation of Emi1	REACT_6821
Signaling by Wnt	REACT_11045
Stabilization of p53	REACT_309
Switching of origins to a post-replicative state	REACT_2148
Synthesis of DNA	REACT_2014
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	REACT_1614
Ubiquitin-dependent degradation of Cyclin D	REACT_938
Ubiquitin-dependent degradation of Cyclin D1	REACT_4

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 46

Cell cycle checkpoint	GO:0000075
G1/S transition of mitotic cell cycle	GO:0000082
S phase of mitotic cell cycle	GO:0000084
Negative regulation of transcription from RNA polymerase II promoter	GO:0000122
Protein polyubiquitination	GO:0000209
M/G1 transition of mitotic cell cycle	GO:0000216
Mitotic cell cycle	GO:0000278
Proteasome complex	GO:0000502
Antigen processing and presentation of peptide antigen via MHC class I	GO:0002474
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:0002479
Protein binding	GO:0005515
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Cytoplasm	GO:0005737
Cytosol	GO:0005829
Proteasome regulatory particle	GO:0005838
Regulation of cellular amino acid metabolic process	GO:0006521
Apoptotic process	GO:0006915
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977
Cytoplasmic sequestering of NF-kappaB	GO:0007253
Transcription factor binding	GO:0008134
Proteasome regulatory particle, base subcomplex	GO:0008540
Gene expression	GO:0010467
Actin cytoskeleton	GO:0015629
Viral reproduction	GO:0016032
RNA metabolic process	GO:0016070
MRNA metabolic process	GO:0016071
Positive regulation of cell growth	GO:0030307
Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	GO:0031145
Positive regulation of protein ubiquitination	GO:0031398
Negative regulation of NF-kappaB transcription factor activity	GO:0032088
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO:0032436
Cellular nitrogen compound metabolic process	GO:0034641
Antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:0042590
Regulation of apoptotic process	GO:0042981
Negative regulation of apoptotic process	GO:0043066
Negative regulation of MAPK cascade	GO:0043409
Negative regulation of DNA damage response, signal transduction by p53 class mediator	GO:0043518
Small molecule metabolic process	GO:0044281
Intermediate filament cytoskeleton	GO:0045111
Positive regulation of cyclin-dependent protein kinase activity	GO:0045737
Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:0051436
Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:0051437
Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:0051439
Proteasome regulatory particle assembly	GO:0070682
Negative regulation of release of cytochrome c from mitochondria	GO:0090201

KEGG Network: None available

Biocarta: None available

Reactome: 47
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	REACT_6954
APC/C-mediated degradation of cell cycle proteins	REACT_6828
APC/C:Cdc20 mediated degradation of mitotic proteins	REACT_6781
APC/C:Cdc20 mediated degradation of Securin	REACT_6871
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	REACT_6761
Apoptosis	REACT_578
Assembly of the pre-replicative complex	REACT_2243
Autodegradation of Cdh1 by Cdh1:APC/C	REACT_6785
Autodegradation of the E3 ubiquitin ligase COP1	REACT_20549
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	REACT_6850
CDK-mediated phosphorylation and removal of Cdc6	REACT_1221
CDT1 association with the CDC6:ORC:origin complex	REACT_1949
Cell Cycle Checkpoints	REACT_1538
Cell Cycle, Mitotic	REACT_152
Cyclin A:Cdk2-associated events at S phase entry	REACT_9029
Cyclin E associated events during G1/S transition	REACT_1574
Degradation of beta-catenin by the destruction complex	REACT_11063
DNA Replication	REACT_383
DNA Replication Pre-Initiation	REACT_734
G1/S DNA Damage Checkpoints	REACT_2254
G1/S Transition	REACT_1783
M/G1 Transition	REACT_1725
Metabolism of amino acids and derivatives	REACT_13
Mitotic G1-G1/S phases	REACT_21267
Mitotic M-M/G1 phases	REACT_21300
Orc1 removal from chromatin	REACT_1156
p53-Dependent G1 DNA Damage Response	REACT_1625
p53-Dependent G1/S DNA damage checkpoint	REACT_85
p53-Independent DNA Damage Response	REACT_2160
p53-Independent G1/S DNA damage checkpoint	REACT_1208
Regulation of activated PAK-2p34 by proteasome mediated degradation	REACT_13464
Regulation of APC/C activators between G1/S and early anaphase	REACT_6837
Regulation of Apoptosis	REACT_13648
Regulation of DNA replication	REACT_829
Regulation of mitotic cell cycle	REACT_21279
Regulation of ornithine decarboxylase (ODC)	REACT_13565
Removal of licensing factors from origins	REACT_207
S Phase	REACT_899
SCF(Skp2)-mediated degradation of p27/p21	REACT_9003
SCF-beta-TrCP mediated degradation of Emi1	REACT_6821
Signaling by Wnt	REACT_11045
Stabilization of p53	REACT_309
Switching of origins to a post-replicative state	REACT_2148
Synthesis of DNA	REACT_2014
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	REACT_1614
Ubiquitin-dependent degradation of Cyclin D	REACT_938
Ubiquitin-dependent degradation of Cyclin D1	REACT_4

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 46
Cell cycle checkpoint	GO:0000075
G1/S transition of mitotic cell cycle	GO:0000082
S phase of mitotic cell cycle	GO:0000084
Negative regulation of transcription from RNA polymerase II promoter	GO:0000122
Protein polyubiquitination	GO:0000209
M/G1 transition of mitotic cell cycle	GO:0000216
Mitotic cell cycle	GO:0000278
Proteasome complex	GO:0000502
Antigen processing and presentation of peptide antigen via MHC class I	GO:0002474
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:0002479
Protein binding	GO:0005515
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Cytoplasm	GO:0005737
Cytosol	GO:0005829
Proteasome regulatory particle	GO:0005838
Regulation of cellular amino acid metabolic process	GO:0006521
Apoptotic process	GO:0006915
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977
Cytoplasmic sequestering of NF-kappaB	GO:0007253
Transcription factor binding	GO:0008134
Proteasome regulatory particle, base subcomplex	GO:0008540
Gene expression	GO:0010467
Actin cytoskeleton	GO:0015629
Viral reproduction	GO:0016032
RNA metabolic process	GO:0016070
MRNA metabolic process	GO:0016071
Positive regulation of cell growth	GO:0030307
Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	GO:0031145
Positive regulation of protein ubiquitination	GO:0031398
Negative regulation of NF-kappaB transcription factor activity	GO:0032088
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO:0032436
Cellular nitrogen compound metabolic process	GO:0034641
Antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:0042590
Regulation of apoptotic process	GO:0042981
Negative regulation of apoptotic process	GO:0043066
Negative regulation of MAPK cascade	GO:0043409
Negative regulation of DNA damage response, signal transduction by p53 class mediator	GO:0043518
Small molecule metabolic process	GO:0044281
Intermediate filament cytoskeleton	GO:0045111
Positive regulation of cyclin-dependent protein kinase activity	GO:0045737
Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:0051436
Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:0051437
Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:0051439
Proteasome regulatory particle assembly	GO:0070682
Negative regulation of release of cytochrome c from mitochondria	GO:0090201

Publications from PubMed Top Help

Publications: 91

Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Altun M, Kramer HB, Willems LI, McDermott JL, Leach CA, Goldenberg SJ, Kumar KG, Konietzny R, Fischer R, Kogan E, Mackeen MM, McGouran J, Khoronenkova SV, Parsons JL, Dianov GL, Nicholson B, Kessler BM
Chem Biol. 2011
PubMed ID: 22118674
Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer.
Li J, Knobloch TJ, Kresty LA, Zhang Z, Lang JC, Schuller DE, Weghorst CM
Anticancer Res. 2011
PubMed ID: 21868508
The oncoprotein p28GANK establishes a positive feedback loop in β-catenin signaling.
Dong LW, Yang GZ, Pan YF, Chen Y, Tan YX, Dai RY, Ren YB, Fu J, Wang HY
Cell Res. 2011
PubMed ID: 21691299
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways.
Fu J, Chen Y, Cao J, Luo T, Qian YW, Yang W, Ren YB, Su B, Cao GW, Yang Y, Yan YQ, Shen F, Wu MC, Feng GS, Wang HY
Hepatology. 2011
PubMed ID: 21254169
Novel gene P28GANK confers multidrug resistance by modulating the expression of MDR-1, Bcl-2 and Bax in osteosarcoma cells.
Wang G, Rong J, Zhou Z, Duo J
Mol Biol (Mosk). 2010
PubMed ID: 21287809
Gankyrin promotes the proliferation of human pancreatic cancer.
Meng Y, He L, Guo X, Tang S, Zhao X, Du R, Jin J, Bi Q, Li H, Nie Y, Liu J, Fan D
Cancer Lett. 2010
PubMed ID: 20483533
Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells.
Man JH, Liang B, Gu YX, Zhou T, Li AL, Li T, Jin BF, Bai B, Zhang HY, Zhang WN, Li WH, Gong WL, Li HY, Zhang XM
J Clin Invest. 2010
PubMed ID: 20628200
Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.
Piton A, Gauthier J, Hamdan FF, Lafrenière RG, Yang Y, Henrion E, Laurent S, Noreau A, Thibodeau P, Karemera L, Spiegelman D, Kuku F, Duguay J, Destroismaisons L, Jolivet P, Côté M, Lachapelle K, Diallo O, Raymond A, Marineau C, Champagne N, Xiong L, Gaspar C, Rivière JB, Tarabeux J, Cossette P, Krebs MO, Rapoport JL, Addington A, Delisi LE, Mottron L, Joober R, Fombonne E, Drapeau P, Rouleau GA
Mol Psychiatry. 2010
PubMed ID: 20479760
Mechanical unfolding of an ankyrin repeat protein.
Serquera D, Lee W, Settanni G, Marszalek PE, Paci E, Itzhaki LS
Biophys J. 2010
PubMed ID: 20371329
Overexpression of a novel gene gankyrin correlates with the malignant phenotype of colorectal cancer.
Tang S, Yang G, Meng Y, Du R, Li X, Fan R, Zhao L, Bi Q, Jin J, Gao L, Zhang L, Li H, Fan M, Wang Y, Wu K, Liu J, Fan D
Cancer Biol Ther. 2010
PubMed ID: 19901563
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
p28GANK inhibits endoplasmic reticulum stress-induced cell death via enhancement of the endoplasmic reticulum adaptive capacity.
Dai RY, Chen Y, Fu J, Dong LW, Ren YB, Yang GZ, Qian YW, Cao J, Tang SH, Yang SL, Wang HY
Cell Res. 2009
PubMed ID: 19736567
Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
The overexpression of multidrug resistance-associated proteins and gankyrin contribute to arsenic trioxide resistance in liver and gastric cancer cells.
Chen X, Zhang M, Liu LX
Oncol Rep. 2009
PubMed ID: 19513507
Chaperone-mediated pathway of proteasome regulatory particle assembly.
Roelofs J, Park S, Haas W, Tian G, McAllister FE, Huo Y, Lee BH, Zhang F, Shi Y, Gygi SP, Finley D
Nature. 2009
PubMed ID: 19412159
Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones.
Kaneko T, Hamazaki J, Iemura S, Sasaki K, Furuyama K, Natsume T, Tanaka K, Murata S
Cell. 2009
PubMed ID: 19490896
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Overexpression of a new gene P28GANK confers multidrug resistance of gastric cancer cells.
Li X, Zhang Y, Xiong C, Jin H, Jing B, Zhang Y, Fan D
Cancer Invest. 2009
PubMed ID: 19235584
Functional characterization of human oncoprotein gankyrin in Zebrafish.
Kim SY, Hur W, Choi JE, Kim D, Wang JS, Yoon HY, Piao LS, Yoon SK
Exp Mol Med. 2009
PubMed ID: 19287195
Involvement of the mitochondrial pathway in p53-independent apoptosis induced by p28GANK knockdown in Hep3B cells.
Wang J, Wang XF, Zhang LG, Xie SY, Li ZL, Li YJ, Li HH, Jiao F
Cytogenet Genome Res. 2009
PubMed ID: 19729910
p28GANK knockdown-derived reactive oxygen species induces apoptosis through mitochondrial dysfunction mediated by p38 in HepG2 cells.
Wang X, Li H, Chen Y, Fu J, Ren Y, Dong L, Tang S, Liu S, Wu M, Wang H
Int J Oncol. 2008
PubMed ID: 18813787
Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells.
Qiu W, Wu J, Walsh EM, Zhang Y, Chen CY, Fujita J, Xiao ZX
Oncogene. 2008
PubMed ID: 18332869
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Association of gankyrin protein expression with early clinical stages and insulin-like growth factor-binding protein 5 expression in human hepatocellular carcinoma.
Umemura A, Itoh Y, Itoh K, Yamaguchi K, Nakajima T, Higashitsuji H, Onoue H, Fukumoto M, Okanoue T, Fujita J
Hepatology. 2008
PubMed ID: 18161051
Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance.
Ortiz CM, Ito T, Tanaka E, Tsunoda S, Nagayama S, Sakai Y, Higashitsuji H, Fujita J, Shimada Y
Int J Cancer. 2008
PubMed ID: 17935131
Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export.
Chen Y, Li HH, Fu J, Wang XF, Ren YB, Dong LW, Tang SH, Liu SQ, Wu MC, Wang HY
Cell Res. 2007
PubMed ID: 18040287
The oncoprotein gankyrin interacts with RelA and suppresses NF-kappaB activity.
Higashitsuji H, Higashitsuji H, Liu Y, Masuda T, Fujita T, Abdel-Aziz HI, Kongkham S, Dawson S, John Mayer R, Itoh Y, Sakurai T, Itoh K, Fujita J
Biochem Biophys Res Commun. 2007
PubMed ID: 17904523
Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.
Mahajan A, Guo Y, Yuan C, Weghorst CM, Tsai MD, Li J
J Mol Biol. 2007
PubMed ID: 17881001
Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.
Wang X, Chen CF, Baker PR, Chen PL, Kaiser P, Huang L
Biochemistry. 2007
PubMed ID: 17323924
Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2.
Nitta RT, Smith CL, Kennedy BK
PLoS ONE. 2007
PubMed ID: 17896003
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.
Baillat D, Hakimi MA, Näär AM, Shilatifard A, Cooch N, Shiekhattar R
Cell. 2005
PubMed ID: 16239144
Towards a proteome-scale map of the human protein-protein interaction network.
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PubMed ID: 16141072
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Genome Res. 2004
PubMed ID: 15489334
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Biochemistry. 2004
PubMed ID: 15379554
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PubMed ID: 15029244
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Proteins. 2004
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Curr Biol. 2003
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Nat Med. 2003
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Nat Immunol. 2003
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Cell. 2003
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Science. 2003
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Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions.
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PubMed ID: 12525503
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PubMed ID: 12477932
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Nature. 2002
PubMed ID: 12466851
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Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.
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Nature. 2002
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Overexpression of p28/gankyrin in human hepatocellular carcinoma and its clinical significance.
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Proc Natl Acad Sci U S A. 2000
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Evidence for a newly discovered cellular anti-HIV-1 phenotype.
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Nat Med. 1998
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An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.
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J Virol. 1998
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J Biol Chem. 1997
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Multiple Grb2-protein complexes in human cancer cells.
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Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	5716	53380	116722
EnsEMBL Gene(s)	ENSG00000101843	ENSMUSG00000031429	N/A
Unigene	Hs.522752	Mm.17640	Rn.116732
Homologene	PSMD10	Psmd10	Psmd10
OMIM	603480	N/A	N/A
GeneCards	PSMD10	N/A	N/A
Beta Cell Genomics	DT.100878410 DT.319114	DT.101388152 DT.488786	N/A
Reactome	O75832	N/A	N/A
Plasma Peptide Atlas	ENSP00000217958	N/A	N/A
WikiGenes	5716	53380	116722

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