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PSMB8

Gene Description:   proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) Synonyms:   PSMB5i, JMP, Ring10, RING10, D6S216, PSMB8, Lmp7, MGC1491, Psmb8, MGC124945, Lmp-7, NKJO, LMP7, D6S216E Orthologs:   Human PSMB8 (protein-coding), Mouse Psmb8 (protein-coding), Rat Psmb8 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid, KEGG Human-Rat: HomoloGene, MGD, RGD, Inparanoid, KEGG Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid, KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
MHC	Human	chr6:29910021..33498585	3.59	688

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd1	Mouse	chr17:34132973..35404440	1.27	98	6 no lod score

(Human) GRCh37 - chr6:32808494..32812712 (4.22 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr17:34334666..34338399 (3.73 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr20:4786260..4789419 (3.16 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for PSMB8: The PSMB8 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs PSMB8   PSME3   Reactome  predicted    PSMB8   PSMD14   Reactome  predicted    PSMB8   PSMB11   Reactome  predicted    PSMB8   PSMA8   Reactome  predicted    PSMB8   PSME4   Reactome  predicted    PSMB8   LSM1   HPRD, IntAct, BioGRID  empirical  15231747  PSMB8   PPP2R1A   IntAct  empirical  16857963  PSMB8   PSMA1   IntAct, Reactome  empirical  16857966  PSMB8   PSMA2   IntAct, Reactome  empirical  15887188  PSMB8   PSMA3   Reactome  predicted    PSMB8   PSMA4   Reactome  predicted    PSMB8   PSMA5   Reactome  predicted    PSMB8   PSMA6   Reactome  predicted    PSMB8   PSMA7   Reactome  predicted    PSMB8   PSMB1   IntAct, Reactome  empirical  14733938  PSMB8   PSMB2   Reactome  predicted    PSMB8   PSMB3   Reactome  predicted    PSMB8   PSMB4   Reactome  predicted    PSMB8   PSMB5   Reactome  predicted    PSMB8   PSMB6   Reactome  predicted    PSMB8   PSMB7   IntAct, Reactome  empirical  20723761  14733938  PSMB8   PSMB8   HPRD  empirical  1429565  PSMB8   PSMB9   IntAct, Reactome  empirical  14733938  PSMB8   PSMB10   Reactome  predicted    PSMB8   PSMC1   Reactome  predicted    PSMB8   PSMC2   Reactome  predicted    PSMB8   PSMC3   Reactome  predicted    PSMB8   PSMC4   Reactome  predicted    PSMB8   PSMC5   Reactome  predicted    PSMB8   PSMC6   Reactome  predicted    PSMB8   PSMD1   Reactome  predicted    PSMB8   PSMD2   Reactome  predicted    PSMB8   PSMD3   Reactome  predicted    PSMB8   PSMD4   Reactome  predicted    PSMB8   PSMD5   Reactome  predicted    PSMB8   PSMD7   Reactome  predicted    PSMB8   PSMD8   Reactome  predicted    PSMB8   PSMD9   Reactome  predicted    PSMB8   PSMD10   Reactome  predicted    PSMB8   PSMD11   Reactome  predicted    PSMB8   PSMD12   Reactome  predicted    PSMB8   PSMD13   Reactome  predicted    PSMB8   PSME1   Reactome  predicted    PSMB8   PSME2   Reactome  predicted    PSMB8   TAP1   HPRD, IntAct  empirical  15488952  PSMB8   TAP2   HPRD, IntAct  empirical  15488952  PSMB8   PSMF1   Reactome  predicted    PSMB8   PSMD6   Reactome  predicted

View all

KEGG Network: 1   Proteasome Human - 3050 Mouse - 3050 Rat - 3050

Biocarta: 1   Antigen Processing and Presentation Human

Reactome: 47   Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins REACT_6954 APC/C-mediated degradation of cell cycle proteins REACT_6828 APC/C:Cdc20 mediated degradation of mitotic proteins REACT_6781 APC/C:Cdc20 mediated degradation of Securin REACT_6871 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 REACT_6761 Apoptosis REACT_578 Assembly of the pre-replicative complex REACT_2243 Autodegradation of Cdh1 by Cdh1:APC/C REACT_6785 Autodegradation of the E3 ubiquitin ligase COP1 REACT_20549 Cdc20:Phospho-APC/C mediated degradation of Cyclin A REACT_6850 CDK-mediated phosphorylation and removal of Cdc6 REACT_1221 CDT1 association with the CDC6:ORC:origin complex REACT_1949 Cell Cycle Checkpoints REACT_1538 Cell Cycle, Mitotic REACT_152 Cyclin A:Cdk2-associated events at S phase entry REACT_9029 Cyclin E associated events during G1/S transition REACT_1574 Degradation of beta-catenin by the destruction complex REACT_11063 DNA Replication REACT_383 DNA Replication Pre-Initiation REACT_734 G1/S DNA Damage Checkpoints REACT_2254 G1/S Transition REACT_1783 M/G1 Transition REACT_1725 Metabolism of amino acids and derivatives REACT_13 Mitotic G1-G1/S phases REACT_21267 Mitotic M-M/G1 phases REACT_21300 Orc1 removal from chromatin REACT_1156 p53-Dependent G1 DNA Damage Response REACT_1625 p53-Dependent G1/S DNA damage checkpoint REACT_85 p53-Independent DNA Damage Response REACT_2160 p53-Independent G1/S DNA damage checkpoint REACT_1208 Regulation of activated PAK-2p34 by proteasome mediated degradation REACT_13464 Regulation of APC/C activators between G1/S and early anaphase REACT_6837 Regulation of Apoptosis REACT_13648 Regulation of DNA replication REACT_829 Regulation of mitotic cell cycle REACT_21279 Regulation of ornithine decarboxylase (ODC) REACT_13565 Removal of licensing factors from origins REACT_207 S Phase REACT_899 SCF(Skp2)-mediated degradation of p27/p21 REACT_9003 SCF-beta-TrCP mediated degradation of Emi1 REACT_6821 Signaling by Wnt REACT_11045 Stabilization of p53 REACT_309 Switching of origins to a post-replicative state REACT_2148 Synthesis of DNA REACT_2014 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A REACT_1614 Ubiquitin-dependent degradation of Cyclin D REACT_938 Ubiquitin-dependent degradation of Cyclin D1 REACT_4

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 31   Cell cycle checkpoint GO:0000075 G1/S transition of mitotic cell cycle GO:0000082 S phase of mitotic cell cycle GO:0000084 Protein polyubiquitination GO:0000209 M/G1 transition of mitotic cell cycle GO:0000216 Mitotic cell cycle GO:0000278 Proteasome complex GO:0000502 Antigen processing and presentation of peptide antigen via MHC class I GO:0002474 Threonine-type endopeptidase activity GO:0004298 Nucleus GO:0005634 Nucleoplasm GO:0005654 Cytoplasm GO:0005737 Cytosol GO:0005829 Proteasome core complex GO:0005839 Regulation of cellular amino acid metabolic process GO:0006521 Apoptosis GO:0006915 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 Peptidase activity GO:0008233 Viral reproduction GO:0016032 RNA metabolic process GO:0016070 MRNA metabolic process GO:0016071 Cytokine-mediated signaling pathway GO:0019221 Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 Cellular nitrogen compound metabolic process GO:0034641 Regulation of apoptosis GO:0042981 Interspecies interaction between organisms GO:0044419 Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051436 Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051437 Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051439 Proteolysis involved in cellular protein catabolic process GO:0051603 Type I interferon-mediated signaling pathway GO:0060337

	KEGG Network: 1 Proteasome Human - 3050 Mouse - 3050 Rat - 3050
	Biocarta: 1 Antigen Processing and Presentation Human
	Reactome: 47 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins REACT_6954 APC/C-mediated degradation of cell cycle proteins REACT_6828 APC/C:Cdc20 mediated degradation of mitotic proteins REACT_6781 APC/C:Cdc20 mediated degradation of Securin REACT_6871 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 REACT_6761 Apoptosis REACT_578 Assembly of the pre-replicative complex REACT_2243 Autodegradation of Cdh1 by Cdh1:APC/C REACT_6785 Autodegradation of the E3 ubiquitin ligase COP1 REACT_20549 Cdc20:Phospho-APC/C mediated degradation of Cyclin A REACT_6850 CDK-mediated phosphorylation and removal of Cdc6 REACT_1221 CDT1 association with the CDC6:ORC:origin complex REACT_1949 Cell Cycle Checkpoints REACT_1538 Cell Cycle, Mitotic REACT_152 Cyclin A:Cdk2-associated events at S phase entry REACT_9029 Cyclin E associated events during G1/S transition REACT_1574 Degradation of beta-catenin by the destruction complex REACT_11063 DNA Replication REACT_383 DNA Replication Pre-Initiation REACT_734 G1/S DNA Damage Checkpoints REACT_2254 G1/S Transition REACT_1783 M/G1 Transition REACT_1725 Metabolism of amino acids and derivatives REACT_13 Mitotic G1-G1/S phases REACT_21267 Mitotic M-M/G1 phases REACT_21300 Orc1 removal from chromatin REACT_1156 p53-Dependent G1 DNA Damage Response REACT_1625 p53-Dependent G1/S DNA damage checkpoint REACT_85 p53-Independent DNA Damage Response REACT_2160 p53-Independent G1/S DNA damage checkpoint REACT_1208 Regulation of activated PAK-2p34 by proteasome mediated degradation REACT_13464 Regulation of APC/C activators between G1/S and early anaphase REACT_6837 Regulation of Apoptosis REACT_13648 Regulation of DNA replication REACT_829 Regulation of mitotic cell cycle REACT_21279 Regulation of ornithine decarboxylase (ODC) REACT_13565 Removal of licensing factors from origins REACT_207 S Phase REACT_899 SCF(Skp2)-mediated degradation of p27/p21 REACT_9003 SCF-beta-TrCP mediated degradation of Emi1 REACT_6821 Signaling by Wnt REACT_11045 Stabilization of p53 REACT_309 Switching of origins to a post-replicative state REACT_2148 Synthesis of DNA REACT_2014 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A REACT_1614 Ubiquitin-dependent degradation of Cyclin D REACT_938 Ubiquitin-dependent degradation of Cyclin D1 REACT_4
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 31 Cell cycle checkpoint GO:0000075 G1/S transition of mitotic cell cycle GO:0000082 S phase of mitotic cell cycle GO:0000084 Protein polyubiquitination GO:0000209 M/G1 transition of mitotic cell cycle GO:0000216 Mitotic cell cycle GO:0000278 Proteasome complex GO:0000502 Antigen processing and presentation of peptide antigen via MHC class I GO:0002474 Threonine-type endopeptidase activity GO:0004298 Nucleus GO:0005634 Nucleoplasm GO:0005654 Cytoplasm GO:0005737 Cytosol GO:0005829 Proteasome core complex GO:0005839 Regulation of cellular amino acid metabolic process GO:0006521 Apoptosis GO:0006915 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 Peptidase activity GO:0008233 Viral reproduction GO:0016032 RNA metabolic process GO:0016070 MRNA metabolic process GO:0016071 Cytokine-mediated signaling pathway GO:0019221 Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 Cellular nitrogen compound metabolic process GO:0034641 Regulation of apoptosis GO:0042981 Interspecies interaction between organisms GO:0044419 Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051436 Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051437 Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051439 Proteolysis involved in cellular protein catabolic process GO:0051603 Type I interferon-mediated signaling pathway GO:0060337

Type 1 Diabetes Publications: 4

• Genetic susceptibility to type 1 diabetes in the intracellular pathway of antigen processing - a subject review and cross-study comparison.
  Sia C, Weinem M
  Rev Diabet Stud. 2005
  PubMed ID: 17491658
   
  
• Relationship of large multifunctional proteasome 7 gene polymorphism with susceptibility to type 1 diabetes mellitus and DR3 gene.
  Ding H, Cheng H, Fu Z, Yan L, Yang G
  Chin Med J (Engl). 2001
  PubMed ID: 11793848
   
  
• Assessment of the non-HLA-DR-DQ contribution to IDDM1 in British Caucasian families: analysis of LMP7 polymorphisms.
  McTernan CL, Stewart LC, Mijovic CH, Barnett AH
  Diabet Med. 2000
  PubMed ID: 11051286
   
  
• Proteasome subunits, low-molecular-mass polypeptides 2 and 7 are hyperexpressed by target cells in autoimmune thyroid disease but not in insulin-dependent diabetes mellitus: implications for autoimmunity.
  Vives-Pi M, Vargas F, James RF, Trowsdale J, Costa M, Sospedra M, Somoza N, Obiols G, Tampé R, Pujol-Borrell R
  Tissue Antigens. 1997
  PubMed ID: 9271825
   
  

Publications: 158

• Association of defective HLA-I expression with antigen processing machinery and their association with clinicopathological characteristics in Kazak patients with esophageal cancer.
  Ayshamgul H, Ma H, Ilyar S, Zhang LW, Abulizi A
  Chin Med J (Engl). 2011
  PubMed ID: 21362330
   
  
• A novel role for the immunoproteasome in retinal function.
  Hussong SA, Roehrich H, Kapphahn RJ, Maldonado M, Pardue MT, Ferrington DA
  Invest Ophthalmol Vis Sci. 2011
  PubMed ID: 20881299
   
  
• Genome-wide association study identifies susceptibility loci for IgA nephropathy.
  Gharavi AG, Kiryluk K, Choi M, Li Y, Hou P, Xie J, Sanna-Cherchi S, Men CJ, Julian BA, Wyatt RJ, Novak J, He JC, Wang H, Lv J, Zhu L, Wang W, Wang Z, Yasuno K, Gunel M, Mane S, Umlauf S, Tikhonova I, Beerman I, Savoldi S, Magistroni R, Ghiggeri GM, Bodria M, Lugani F, Ravani P, Ponticelli C, Allegri L, Boscutti G, Frasca G, Amore A, Peruzzi L, Coppo R, Izzi C, Viola BF, Prati E, Salvadori M, Mignani R, Gesualdo L, Bertinetto F, Mesiano P, Amoroso A, Scolari F, Chen N, Zhang H, Lifton RP
  Nat Genet. 2011
  PubMed ID: 21399633
   
  
• A dominant role for the immunoproteasome in CD8+ T cell responses to murine cytomegalovirus.
  Hutchinson S, Sims S, O'Hara G, Silk J, Gileadi U, Cerundolo V, Klenerman P
  PLoS One. 2011
  PubMed ID: 21304910
   
  
• Initial characterization of the human central proteome.
  Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
  BMC Syst Biol. 2011
  PubMed ID: 21269460
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• PSMB8 encoding the β5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome.
  Agarwal AK, Xing C, DeMartino GN, Mizrachi D, Hernandez MD, Sousa AB, Martínez de Villarreal L, dos Santos HG, Garg A
  Am J Hum Genet. 2010
  PubMed ID: 21129723
   
  
• Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice.
  Moebius J, van den Broek M, Groettrup M, Basler M
  Eur J Immunol. 2010
  PubMed ID: 21108466
   
  
• Reduced immunoproteasome formation and accumulation of immunoproteasomal precursors in the brains of lymphocytic choriomeningitis virus-infected mice.
  Kremer M, Henn A, Kolb C, Basler M, Moebius J, Guillaume B, Leist M, Van den Eynde BJ, Groettrup M
  J Immunol. 2010
  PubMed ID: 20881186
   
  
• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
  Diabetes Care. 2010
  PubMed ID: 20628086
   
  
• Prevention of experimental colitis by a selective inhibitor of the immunoproteasome.
  Basler M, Dajee M, Moll C, Groettrup M, Kirk CJ
  J Immunol. 2010
  PubMed ID: 20525886
   
  
• No association of TAP and LMP genetic polymorphism in human brucellosis and its complications.
  Bravo MJ, Colmenero JD, Queipo-Ortuño MI, Martín J, Lavado R, Alonso A, Caballero A
  Hum Immunol. 2010
  PubMed ID: 20470844
   
  
• Genetic variation in the LMP/TAP gene and outcomes of hepatitis B virus infection in the Chinese population.
  Shi C, Qian YH, Su J, Luo SS, Gu J, You H, Cui Q, Lin YD, Dong MH, Yu RB
  Epidemiol Infect. 2010
  PubMed ID: 20525414
   
  
• Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
  Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R
  Pediatr Pulmonol. 2010
  PubMed ID: 20503287
   
  
• Immunoproteasome deficiency alters retinal proteasome's response to stress.
  Hussong SA, Kapphahn RJ, Phillips SL, Maldonado M, Ferrington DA
  J Neurochem. 2010
  PubMed ID: 20345760
   
  
• Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
  Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL, Thio CL
  J Infect Dis. 2010
  PubMed ID: 20331378
   
  
• Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses.
  Hensley SE, Zanker D, Dolan BP, David A, Hickman HD, Embry AC, Skon CN, Grebe KM, Griffin TA, Chen W, Bennink JR, Yewdell JW
  J Immunol. 2010
  PubMed ID: 20228196
   
  
• PSMB8 (LMP7) but not PSMB9 (LMP2) gene polymorphisms are associated to pigeon breeder's hypersensitivity pneumonitis.
  Camarena A, Aquino-Galvez A, Falfán-Valencia R, Sánchez G, Montaño M, Ramos C, Juárez A, García-de-Alba C, Granados J, Selman M
  Respir Med. 2010
  PubMed ID: 20153157
   
  
• Ontogenesis of rat immune system: Proteasome expression in different cell populations of the developing thymus.
  Melnikova VI, Sharova NP, Maslova EV, Voronova SN, Zakharova LA
  Cell Immunol. 2010
  PubMed ID: 20888554
   
  
• Critical role for the immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection.
  Tu L, Moriya C, Imai T, Ishida H, Tetsutani K, Duan X, Murata S, Tanaka K, Shimokawa C, Hisaeda H, Himeno K
  Eur J Immunol. 2009
  PubMed ID: 19830724
   
  
• Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
  Am J Hum Genet. 2009
  PubMed ID: 19913121
   
  
• High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
  Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA
  PLoS Genet. 2009
  PubMed ID: 19851445
   
  
• Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon-inducible immunoproteasome.
  Yang Z, Gagarin D, St Laurent G, Hammell N, Toma I, Hu CA, Iwasa A, McCaffrey TA
  Arterioscler Thromb Vasc Biol. 2009
  PubMed ID: 19443843
   
  
• A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.
  Muchamuel T, Basler M, Aujay MA, Suzuki E, Kalim KW, Lauer C, Sylvain C, Ring ER, Shields J, Jiang J, Shwonek P, Parlati F, Demo SD, Bennett MK, Kirk CJ, Groettrup M
  Nat Med. 2009
  PubMed ID: 19525961
   
  
• Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis.
  Maksymowych WP, Inman RD, Gladman DD, Reeve JP, Pope A, Rahman P
  Arthritis Rheum. 2009
  PubMed ID: 19404951
   
  
• Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma.
  Mehta AM, Jordanova ES, Corver WE, van Wezel T, Uh HW, Kenter GG, Jan Fleuren G
  Genes Chromosomes Cancer. 2009
  PubMed ID: 19202550
   
  
• In situ analysis of the antigen-processing machinery in acute myeloid leukaemic blasts by tissue microarray.
  Hoves S, Aigner M, Pfeiffer C, Laumer M, Obermann EC, Mackensen A
  Leukemia. 2009
  PubMed ID: 19148137
   
  
• Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
  Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
  Pediatr Infect Dis J. 2009
  PubMed ID: 19258923
   
  
• Upregulation of the immunoproteasome in peripheral blood mononuclear cells of patients with IgA nephropathy.
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• Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism: studies in humans and mice.
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• Herpes simplex virus type I infection of mature dendritic cells leads to reduced LMP7-mRNA-expression levels.
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• [Allele polymorphism of genes coding proteasome subunits is associated with an enhanced risk for arterial hypertension in adolescents]
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• Differential expression of constitutive and inducible proteasome subunits in human monocyte-derived DC differentiated in the presence of IFN-alpha or IL-4.
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• [An experimental study on the relationship between proteasome LMP7 subunit and alcoholic liver disease]
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• The proteasome immunosubunit multicatalytic endopeptidase complex-like 1 is a T-cell-intrinsic factor influencing homeostatic expansion.
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• Variation in HLA class I antigen-processing genes and susceptibility to human papillomavirus type 16-associated cervical cancer.
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• Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
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• Strong associations of psoriasis with antigen processing LMP and transport genes TAP differ by gender and phenotype.
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  Genes Immun. 2007
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• Genetic polymorphisms of LMP/TAP gene and hepatitis B virus infection risk in the Chinese population.
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• Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis.
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• Rates of processing determine the immunogenicity of immunoproteasome-generated epitopes.
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• Role of immunoproteasome catalytic subunits in the immune response to hepatitis B virus.
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• Differential expression of genes encoding constitutive and inducible 20S proteasomal core subunits in the testis and epididymis of theophylline- or 1,3-dinitrobenzene-exposed rats.
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• Heat shock up-regulates lmp2 and lmp7 and enhances presentation of immunoproteasome-dependent epitopes.
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• Immunoproteasome subunit deficiencies impact differentially on two immunodominant influenza virus-specific CD8+ T cell responses.
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• Immunoproteasomes are essential for clearance of Listeria monocytogenes in nonlymphoid tissues but not for induction of bacteria-specific CD8+ T cells.
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• Role of immunoproteasomes in cross-presentation.
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• The ubiquitin-proteasome system plays essential roles in presenting an 8-mer CTL epitope expressed in APC to corresponding CD8+ T cells.
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• BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
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  PLoS Biol. 2006
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• T cells lacking immunoproteasome subunits MECL-1 and LMP7 hyperproliferate in response to polyclonal mitogens.
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• Proteasomes shape the repertoire of T cells participating in antigen-specific immune responses.
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  Proc Natl Acad Sci U S A. 2006
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• Regulation of the neuronal proteasome by Zif268 (Egr1).
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  J Neurosci. 2006
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• Tumor cell lines expressing the proteasome subunit isoform LMP7E1 exhibit immunoproteasome deficiency.
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  Cancer Res. 2006
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• Immuno-proteasome subunit LMP7 is up-regulated in the ischemic kidney in an experimental model of renovascular hypertension.
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  Int J Biochem Cell Biol. 2006
  PubMed ID: 16769238
   
  
• Transcriptome analysis of human gastric cancer.
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  Mamm Genome. 2005
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• Pharmacogenomics of responsiveness to interferon IFN-beta treatment in multiple sclerosis: a genetic screen of 100 type I interferon-inducible genes.
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• [The frequency of allelic polymorphism of genes encoding immunoproteasome catalytic subunits in acute coronary syndrome patients]
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• [Association between LMP2/LMP7 gene polymorphism and the infection of hepatitis B virus]
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• Antisense transcription in the mammalian transcriptome.
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  Science. 2005
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• The transcriptional landscape of the mammalian genome.
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  Science. 2005
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• Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination.
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• IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response.
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• IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.
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• Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.
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• Association study of LMP gene polymorphisms in Mexican patients with spondyloarthritis.
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• Hepatitis C virus non-structural protein NS3 interacts with LMP7, a component of the immunoproteasome, and affects its proteasome activity.
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• Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach.
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• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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  Genome Res. 2004
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• Gene expression profiling in spleens of deoxynivalenol-exposed mice: immediate early genes as primary targets.
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• Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus.
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• HIV-1 tat protein modulates the generation of cytotoxic T cell epitopes by modifying proteasome composition and enzymatic activity.
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• A protein interaction framework for human mRNA degradation.
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• The genetic association database.
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• Mammalian Cdh1/Fzr mediates its own degradation.
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• The genomic sequence and comparative analysis of the rat major histocompatibility complex.
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• Complete sequencing and characterization of 21,243 full-length human cDNAs.
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  Nat Genet. 2004
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• The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G.
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• Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex.
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• The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity.
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• The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity.
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• HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation.
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• The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif.
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• The DNA sequence and analysis of human chromosome 6.
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  Nature. 2003
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• Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.
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• Genes of the LMP/TAP cluster are associated with the human autoimmune disease vitiligo.
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• HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability.
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• Virology. Weapons of mutational destruction.
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• Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts.
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• The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA.
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• DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses.
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• DNA deamination mediates innate immunity to retroviral infection.
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• Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.
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• Hypermutation of HIV-1 DNA in the absence of the Vif protein.
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• Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions.
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