PRNP

Summary Top Help

Gene Description:

prion protein

Synonyms:

prion, CD230, AI325101, Prn, Prn-i, PRNP, PrP, PrP33-35C, PrPSc, Prn-p, ASCR, PrP27-30, GSS, CJD, Prnp, PRIP, PrPC, Sinc, PrPc, PrP, AA960666

Orthologs:

Human PRNP (protein-coding), Mouse Prnp (protein-coding), Rat Prnp (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1 Rat: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd13	Mouse	chr2:114118625..158330390	44.21	582	3 no lod score

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm27	Rat	chr3:96506745..149496698	52.99	606

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr20:4666797..4682236 (15.44 kb) View in Genome Browser

(Mouse) NCBIM37 - chr2:131735664..131764167 (28.50 kb) View in Genome Browser

(Rat) RGSC3.4 - chr3:119676137..119691507 (15.37 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PRNP:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PRNP:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 1

Biocarta: 1

Reactome: 3

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 37

Publications from PubMed Top Help

Type 1 Diabetes Publications: 7

Publications: 1139

Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.
Kudo W, Lee HP, Zou WQ, Wang X, Perry G, Zhu X, Smith MA, Petersen RB, Lee HG
Hum Mol Genet. 2012
PubMed ID: 22100763
Depressive-like behaviour of mice lacking cellular prion protein.
Gadotti VM, Bonfield SP, Zamponi GW
Behav Brain Res. 2012
PubMed ID: 21439331
The effects of host age on the transport of complement-bound complexes to the spleen and the pathogenesis of intravenous scrapie infection.
Brown KL, Gossner A, Mok S, Mabbott NA
J Virol. 2012
PubMed ID: 22031932
A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation.
Westergard L, Turnbaugh JA, Harris DA
J Biol Chem. 2011
PubMed ID: 22025612
Contribution of individual histidines to prion protein copper binding.
Davies P, McHugh PC, Hammond VJ, Marken F, Brown DR
Biochemistry. 2011
PubMed ID: 22039779
Expression of the prion-like protein Shadoo in the developing mouse embryo.
Young R, Bouet S, Polyte J, Le Guillou S, Passet B, Vilotte M, Castille J, Beringue V, Le Provost F, Laude H, Vilotte JL
Biochem Biophys Res Commun. 2011
PubMed ID: 22093825
Structural polymorphism in amyloids: new insights from studies with Y145Stop prion protein fibrils.
Jones EM, Wu B, Surewicz K, Nadaud PS, Helmus JJ, Chen S, Jaroniec CP, Surewicz WK
J Biol Chem. 2011
PubMed ID: 22002245
The octapeptide repeat PrP(C) region and cobalamin-deficient polyneuropathy of the rat.
Scalabrino G, Mutti E, Veber D, Rodriguez Menendez V, Novembrino C, Calligaro A, Tredici G
Muscle Nerve. 2011
PubMed ID: 22102467
Long-time scale fluctuations of human prion protein determined by restrained MD simulations.
Khorvash M, Lamour G, Gsponer J
Biochemistry. 2011
PubMed ID: 22032174
Copper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions.
Thakur AK, Srivastava AK, Srinivas V, Chary KV, Rao CM
J Biol Chem. 2011
PubMed ID: 21900252
Amyloid-β-induced synapse damage is mediated via cross-linkage of cellular prion proteins.
Bate C, Williams A
J Biol Chem. 2011
PubMed ID: 21900234
Endogenous prion protein attenuates experimentally induced colitis.
Martin GR, Keenan CM, Sharkey KA, Jirik FR
Am J Pathol. 2011
PubMed ID: 21924230
Leu138 in bovine prion peptide fibrils is involved in seeding discrimination related to codon 129 M/V polymorphism in the prion peptide seeding experiment.
Liao TY, Lee LY, Chen RP
FEBS J. 2011
PubMed ID: 21920025
Increased excitatory amino acid transport into murine prion protein knockout astrocytes cultured in vitro.
Pathmajeyan MS, Patel SA, Carroll JA, Seib T, Striebel JF, Bridges RJ, Chesebro B
Glia. 2011
PubMed ID: 21766339
Comparison of mRNA expression patterns of class B scavenger receptors in BV2 microglia upon exposure to amyloidogenic fragments of beta-amyloid and prion proteins.
Kouadir M, Yang L, Tu J, Yin X, Zhou X, Zhao D
DNA Cell Biol. 2011
PubMed ID: 21631281
Cellular prion protein conformation and function.
Damberger FF, Christen B, Pérez DR, Hornemann S, Wüthrich K
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21987789
Prevalent mutations of human prion protein: a molecular modeling and molecular dynamics study.
Behmard E, Abdolmaleki P, Asadabadi EB, Jahandideh S
J Biomol Struct Dyn. 2011
PubMed ID: 21875156
Tau inhibits tubulin oligomerization induced by prion protein.
Osiecka KM, Nieznanska H, Skowronek KJ, Jozwiak J, Nieznanski K
Biochim Biophys Acta. 2011
PubMed ID: 21763357
Toward the molecular basis of inherited prion diseases: NMR structure of the human prion protein with V210I mutation.
Biljan I, Ilc G, Giachin G, Raspadori A, Zhukov I, Plavec J, Legname G
J Mol Biol. 2011
PubMed ID: 21839748
Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion protein.
Nunziante M, Ackermann K, Dietrich K, Wolf H, Gädtke L, Gilch S, Vorberg I, Groschup M, Schätzl HM
J Biol Chem. 2011
PubMed ID: 21835918
A nine amino acid domain is essential for mutant prion protein toxicity.
Westergard L, Turnbaugh JA, Harris DA
J Neurosci. 2011
PubMed ID: 21957261
Spongiform encephalopathy in transgenic mice expressing a point mutation in the β2-α2 loop of the prion protein.
Sigurdson CJ, Joshi-Barr S, Bett C, Winson O, Manco G, Schwarz P, Rülicke T, Nilsson KP, Margalith I, Raeber A, Peretz D, Hornemann S, Wüthrich K, Aguzzi A
J Neurosci. 2011
PubMed ID: 21957246
Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.
Griffiths HH, Whitehouse IJ, Baybutt H, Brown D, Kellett KA, Jackson CD, Turner AJ, Piccardo P, Manson JC, Hooper NM
J Biol Chem. 2011
PubMed ID: 21795680
Dynamic changes and surveillance function of prion protein expression in gastric cancer drug resistance.
Wang JH, Du JP, Zhang YH, Zhao XJ, Fan RY, Wang ZH, Wu ZT, Han Y
World J Gastroenterol. 2011
PubMed ID: 22046086
Generation of Sprn-regulated reporter mice reveals gonadic spatial expression of the prion-like protein Shadoo in mice.
Young R, Le Guillou S, Tilly G, Passet B, Vilotte M, Castille J, Beringue V, Le Provost F, Laude H, Vilotte JL
Biochem Biophys Res Commun. 2011
PubMed ID: 21871438
Intermolecular alignment in Y145Stop human prion protein amyloid fibrils probed by solid-state NMR spectroscopy.
Helmus JJ, Surewicz K, Apostol MI, Surewicz WK, Jaroniec CP
J Am Chem Soc. 2011
PubMed ID: 21827207
Relative and regional stabilities of the hamster, mouse, rabbit, and bovine prion proteins toward urea unfolding assessed by nuclear magnetic resonance and circular dichroism spectroscopies.
Julien O, Chatterjee S, Bjorndahl TC, Sweeting B, Acharya S, Semenchenko V, Chakrabartty A, Pai EF, Wishart DS, Sykes BD, Cashman NR
Biochemistry. 2011
PubMed ID: 21800884
Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171.
Striebel JF, Race B, Meade-White KD, LaCasse R, Chesebro B
PLoS Pathog. 2011
PubMed ID: 21980292
Clinical characterization of a kindred with a novel 12-octapeptide repeat insertion in the prion protein gene.
Kumar N, Boeve BF, Boot BP, Orr CF, Duffy J, Woodruff BK, Nair AK, Ellison J, Kuntz K, Kantarci K, Jack CR, Westmoreland BF, Fields JA, Baker M, Rademakers R, Parisi JE, Dickson DW
Arch Neurol. 2011
PubMed ID: 21911696
Chronic wasting disease prion trafficking via the autonomic nervous system.
Seelig DM, Mason GL, Telling GC, Hoover EA
Am J Pathol. 2011
PubMed ID: 21777560
Orally administered prion protein is incorporated by m cells and spreads into lymphoid tissues with macrophages in prion protein knockout mice.
Takakura I, Miyazawa K, Kanaya T, Itani W, Watanabe K, Ohwada S, Watanabe H, Hondo T, Rose MT, Mori T, Sakaguchi S, Nishida N, Katamine S, Yamaguchi T, Aso H
Am J Pathol. 2011
PubMed ID: 21763679
Conserved properties of human and bovine prion strains on transmission to guinea pigs.
Safar JG, Giles K, Lessard P, Letessier F, Patel S, Serban A, Dearmond SJ, Prusiner SB
Lab Invest. 2011
PubMed ID: 21727894
Experience with preventive genetic testing of corneal donors in slovakia.
Mitrová E, Cernák A, Slivarichová D, Koščová S, Bernovská V, Cernák M
Cornea. 2011
PubMed ID: 21508834
The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein.
Cissé M, Duplan E, Guillot-Sestier MV, Rumigny J, Bauer C, Pagès G, Orzechowski HD, Slack BE, Checler F, Vincent B
J Biol Chem. 2011
PubMed ID: 21586567
Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry.
Deriziotis P, André R, Smith DM, Goold R, Kinghorn KJ, Kristiansen M, Nathan JA, Rosenzweig R, Krutauz D, Glickman MH, Collinge J, Goldberg AL, Tabrizi SJ
EMBO J. 2011
PubMed ID: 21743439
Initial fate of prions upon peripheral infection: half-life, distribution, clearance, and tissue uptake.
Urayama A, Morales R, Niehoff ML, Banks WA, Soto C
FASEB J. 2011
PubMed ID: 21555356
Silencing of cellular prion protein (PrPC) expression by DNA-antisense oligonucleotides induces autophagy-dependent cell death in glioma cells.
Barbieri G, Palumbo S, Gabrusiewicz K, Azzalin A, Marchesi N, Spedito A, Biggiogera M, Sbalchiero E, Mazzini G, Miracco C, Pirtoli L, Kaminska B, Comincini S
Autophagy. 2011
PubMed ID: 21478678
Acute exposure to prion infection induces transient oxidative stress progressing to be cumulatively deleterious with chronic propagation in vitro.
Haigh CL, McGlade AR, Lewis V, Masters CL, Lawson VA, Collins SJ
Free Radic Biol Med. 2011
PubMed ID: 21466851
Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice.
Cissé M, Sanchez PE, Kim DH, Ho K, Yu GQ, Mucke L
J Neurosci. 2011
PubMed ID: 21775587
Copper(II)-induced secondary structure changes and reduced folding stability of the prion protein.
Younan ND, Klewpatinond M, Davies P, Ruban AV, Brown DR, Viles JH
J Mol Biol. 2011
PubMed ID: 21619885
Dissociation of infectivity from seeding ability in prions with alternate docking mechanism.
Miller MB, Geoghegan JC, Supattapone S
PLoS Pathog. 2011
PubMed ID: 21779169
An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein.
Vanderperre B, Staskevicius AB, Tremblay G, McCoy M, O'Neill MA, Cashman NR, Roucou X
FASEB J. 2011
PubMed ID: 21478263
Resistance against apoptosis by the cellular prion protein is dependent on its glycosylation status in oral HSC-2 and colon LS 174T cancer cells.
Yap YH, Say YH
Cancer Lett. 2011
PubMed ID: 21439722
Developmental influence of the cellular prion protein on the gene expression profile in mouse hippocampus.
Benvegnù S, Roncaglia P, Agostini F, Casalone C, Corona C, Gustincich S, Legname G
Physiol Genomics. 2011
PubMed ID: 21406608
Molecular origin of Gerstmann-Sträussler-Scheinker syndrome: insight from computer simulation of an amyloidogenic prion peptide.
Daidone I, Di Nola A, Smith JC
Biophys J. 2011
PubMed ID: 21689534
Neuroprotective effects of the cellular prion protein in autoimmune optic neuritis.
Williams SK, Fairless R, Weise J, Kalinke U, Schulz-Schaeffer W, Diem R
Am J Pathol. 2011
PubMed ID: 21641403
Inherited prion disease with 4-octapeptide repeat insertion: disease requires the interaction of multiple genetic risk factors.
Kaski DN, Pennington C, Beck J, Poulter M, Uphill J, Bishop MT, Linehan JM, O'Malley C, Wadsworth JD, Joiner S, Knight RS, Ironside JW, Brandner S, Collinge J, Mead S
Brain. 2011
PubMed ID: 21616973
P-selectin glycoprotein ligand-1 modulates immune inflammatory responses in the enteric lamina propria.
Nuñez-Andrade N, Lamana A, Sancho D, Gisbert JP, Gonzalez-Amaro R, Sanchez-Madrid F, Urzainqui A
J Pathol. 2011
PubMed ID: 21432853
Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain.
Takahashi RH, Tobiume M, Sato Y, Sata T, Gouras GK, Takahashi H
Neuropathology. 2011
PubMed ID: 21062360
Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein.
Barry AE, Klyubin I, Mc Donald JM, Mably AJ, Farrell MA, Scott M, Walsh DM, Rowan MJ
J Neurosci. 2011
PubMed ID: 21593310
The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication.
Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Müller V, Krishnan R, Vabulas RM, Kretzschmar HA, Lindquist S, Hartl FU, Multhaup G, Winklhofer KF, Tatzelt J
EMBO J. 2011
PubMed ID: 21441896
Aged PrP null mice show defective processing of neuregulins in the peripheral nervous system.
Benvegnù S, Gasperini L, Legname G
Mol Cell Neurosci. 2011
PubMed ID: 21334441
Heat shock protein 104 inhibited the fibrillization of prion peptide 106-126 and disassembled prion peptide 106-126 fibrils in vitro.
Liu YH, Han YL, Song J, Wang Y, Jing YY, Shi Q, Tian C, Wang ZY, Li CP, Han J, Dong XP
Int J Biochem Cell Biol. 2011
PubMed ID: 21296677
Correlation of polydispersed prion protein and characteristic pathology in the thalamus in variant Creutzfeldt-Jakob disease: implication of small oligomeric species.
Choi YP, Gröner A, Ironside JW, Head MW
Brain Pathol. 2011
PubMed ID: 21029243
An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity.
Solomon IH, Khatri N, Biasini E, Massignan T, Huettner JE, Harris DA
J Biol Chem. 2011
PubMed ID: 21385869
Amyloid features and neuronal toxicity of mature prion fibrils are highly sensitive to high pressure.
El Moustaine D, Perrier V, Acquatella-Tran Van Ba I, Meersman F, Ostapchenko VG, Baskakov IV, Lange R, Torrent J
J Biol Chem. 2011
PubMed ID: 21357423
Threshold for epileptiform activity is elevated in prion knockout mice.
Ratté S, Vreugdenhil M, Boult JK, Patel A, Asante EA, Collinge J, Jefferys JG
Neuroscience. 2011
PubMed ID: 21277354
Atomic structures suggest determinants of transmission barriers in mammalian prion disease.
Apostol MI, Wiltzius JJ, Sawaya MR, Cascio D, Eisenberg D
Biochemistry. 2011
PubMed ID: 21323366
Unaltered prion protein expression in Alzheimer disease patients.
Saijo E, Scheff SW, Telling GC
Prion. 2011
PubMed ID: 21654203
A Chinese Creutzfeldt-Jakob disease patient with E196K mutation in PRNP.
Shi Q, Chen C, Song XN, Gao C, Tian C, Zhou W, Song XH, Yao LS, Han J, Dong XP
Prion. 2011
PubMed ID: 21597335
Genetic prion disease with codon 196 PRNP mutation: clinical and pathological findings.
Schelzke G, Eigenbrod S, Romero C, Varges D, Breithaupt M, Taratuto AL, Kretzschmar HA, Zerr I
Neurobiol Aging. 2011
PubMed ID: 21232818
Normal modes of prion proteins: from native to infectious particle.
Samson AO, Levitt M
Biochemistry. 2011
PubMed ID: 21338080
Conserved stress-protective activity between prion protein and Shadoo.
Sakthivelu V, Seidel RP, Winklhofer KF, Tatzelt J
J Biol Chem. 2011
PubMed ID: 21257747
Monoacylated cellular prion protein modifies cell membranes, inhibits cell signaling, and reduces prion formation.
Bate C, Williams A
J Biol Chem. 2011
PubMed ID: 21212283
Alteration of the endocannabinoid system in mouse brain during prion disease.
Petrosino S, Ménard B, Zsürger N, Di Marzo V, Chabry J
Neuroscience. 2011
PubMed ID: 21195746
Recovery of small infectious PrP(res) aggregates from prion-infected cultured cells.
Anaya ZE, Savistchenko J, Massonneau V, Lacroux C, Andréoletti O, Vilette D
J Biol Chem. 2011
PubMed ID: 21212268
Generation of a new form of human PrP(Sc) in vitro by interspecies transmission from cervid prions.
Barria MA, Telling GC, Gambetti P, Mastrianni JA, Soto C
J Biol Chem. 2011
PubMed ID: 21209079
Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides.
Karpuj MV, Gelibter-Niv S, Tiran A, Rambold A, Tatzelt J, Nunziante M, Schatzl HM
J Biol Chem. 2011
PubMed ID: 21156803
Sheep and goat BSE propagate more efficiently than cattle BSE in human PrP transgenic mice.
Padilla D, Béringue V, Espinosa JC, Andreoletti O, Jaumain E, Reine F, Herzog L, Gutierrez-Adan A, Pintado B, Laude H, Torres JM
PLoS Pathog. 2011
PubMed ID: 21445238
Co-occurrence of types 1 and 2 PrP(res) in sporadic Creutzfeldt-Jakob disease MM1.
Kobayashi A, Mizukoshi K, Iwasaki Y, Miyata H, Yoshida Y, Kitamoto T
Am J Pathol. 2011
PubMed ID: 21356381
Comprehensive neuropathologic analysis of genetic prion disease associated with the E196K mutation in PRNP reveals phenotypic heterogeneity.
Eigenbrod S, Frick P, Giese A, Schelzke G, Zerr I, Kretzschmar HA
J Neuropathol Exp Neurol. 2011
PubMed ID: 21293298
Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteins.
Hong L, Simon JD
Metallomics. 2011
PubMed ID: 21116546
High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein.
Corsaro A, Thellung S, Bucciarelli T, Scotti L, Chiovitti K, Villa V, D'Arrigo C, Aceto A, Florio T
Int J Biochem Cell Biol. 2011
PubMed ID: 21094273
Cytosolic PrP induces apoptosis of cell by disrupting microtubule assembly.
Li XL, Wang GR, Jing YY, Pan MM, Dong CF, Zhou RM, Wang ZY, Shi Q, Gao C, Dong XP
J Mol Neurosci. 2011
PubMed ID: 20838930
Human prion protein mutants with deleted and inserted octarepeats undergo different pathways to trigger cell apoptosis.
Xu K, Wang X, Shi Q, Chen C, Tian C, Li XL, Zhou RM, Chu YL, Dong XP
J Mol Neurosci. 2011
PubMed ID: 20526696
Possible involvement of calpain-like activity in normal processing of cellular prion protein.
Hachiya N, Komata Y, Harguem S, Nishijima K, Kaneko K
Neurosci Lett. 2011
PubMed ID: 21193014
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases.
Sandberg MK, Al-Doujaily H, Sharps B, Clarke AR, Collinge J
Nature. 2011
PubMed ID: 21350487
Defining the pathway of worm-like amyloid fibril formation by the mouse prion protein by delineation of the productive and unproductive oligomerization reactions.
Jain S, Udgaonkar JB
Biochemistry. 2011
PubMed ID: 21214263
Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles.
Encalada SE, Szpankowski L, Xia CH, Goldstein LS
Cell. 2011
PubMed ID: 21335237
No association between genetic polymorphism at codon 129 of the prion protein gene and primary progressive multiple sclerosis.
Stüve O, Wang J, Chan A, Hemmer B, Cepok S, Nessler S, Zipp F, Goldman MD, Meuth SG, Korth C, Lambracht-Washington D
Arch Neurol. 2011
PubMed ID: 21320996
Cellular prion protein promotes glucose uptake through the Fyn-HIF-2α-Glut1 pathway to support colorectal cancer cell survival.
Li QQ, Sun YP, Ruan CP, Xu XY, Ge JH, He J, Xu ZD, Wang Q, Gao WC
Cancer Sci. 2011
PubMed ID: 21265952
Crucial role for prion protein membrane anchoring in the neuroinvasion and neural spread of prion infection.
Klingeborn M, Race B, Meade-White KD, Rosenke R, Striebel JF, Chesebro B
J Virol. 2011
PubMed ID: 21123371
Reticulon 3 attenuates the clearance of cytosolic prion aggregates via inhibiting autophagy.
Chen R, Jin R, Wu L, Ye X, Yang Y, Luo K, Wang W, Wu D, Ye X, Huang L, Huang T, Xiao G
Autophagy. 2011
PubMed ID: 21119307
Interactions of the prion peptide (PrP 106-126) with brain capillary endothelial cells: coordinated cell killing and remodeling of intercellular junctions.
Cooper I, Cohen-Kashi Malina K, Cagnotto A, Bazzoni G, Salmona M, Teichberg VI
J Neurochem. 2011
PubMed ID: 20804519
Enhanced susceptibility of T lymphocytes to oxidative stress in the absence of the cellular prion protein.
Aude-Garcia C, Villiers C, Candéias SM, Garrel C, Bertrand C, Collin V, Marche PN, Jouvin-Marche E
Cell Mol Life Sci. 2011
PubMed ID: 20717837
Comparison studies of the structural stability of rabbit prion protein with human and mouse prion proteins.
Zhang J
J Theor Biol. 2011
PubMed ID: 20970434
Tissue- and cell type-specific modification of prion protein (PrP)-like protein Doppel, which affects PrP endoproteolysis.
Sakudo A, Onodera T
Biochem Biophys Res Commun. 2011
PubMed ID: 21144827
Instability of the octarepeat region of the human prion protein gene.
Li B, Qing L, Yan J, Kong Q
PLoS One. 2011
PubMed ID: 22028931
The N-terminal, polybasic region is critical for prion protein neuroprotective activity.
Turnbaugh JA, Westergard L, Unterberger U, Biasini E, Harris DA
PLoS One. 2011
PubMed ID: 21980526
Expression of prion protein in mouse erythroid progenitors and differentiating murine erythroleukemia cells.
Panigaj M, Glier H, Wildova M, Holada K
PLoS One. 2011
PubMed ID: 21912705
Effect of hydrophobic mutations in the H2-H3 subdomain of prion protein on stability and conversion in vitro and in vivo.
Hafner-Bratkovič I, Gaedtke L, Ondracka A, Veranič P, Vorberg I, Jerala R
PLoS One. 2011
PubMed ID: 21909425
Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.
Khalifé M, Young R, Passet B, Halliez S, Vilotte M, Jaffrezic F, Marthey S, Béringue V, Vaiman D, Le Provost F, Laude H, Vilotte JL
PLoS One. 2011
PubMed ID: 21858045
Molecular interaction of TPPP with PrP antagonized the CytoPrP-induced disruption of microtubule structures and cytotoxicity.
Zhou RM, Jing YY, Guo Y, Gao C, Zhang BY, Chen C, Shi Q, Tian C, Wang ZY, Gong HS, Han J, Xu BL, Dong XP
PLoS One. 2011
PubMed ID: 21857997
Cellular prion protein protects from inflammatory and neuropathic pain.
Gadotti VM, Zamponi GW
Mol Pain. 2011
PubMed ID: 21843375
Metal-binding ability of human prion protein fragment peptides analyzed by column switch HPLC.
Kojima A, Mabuchi Y, Konishi M, Okihara R, Nagano M, Akizawa T
Chem Pharm Bull (Tokyo). 2011
PubMed ID: 21804240
Genetic cross-interaction between APOE and PRNP in sporadic Alzheimer's and Creutzfeldt-Jakob diseases.
Calero O, Bullido MJ, Clarimón J, Frank-García A, Martínez-Martín P, Lleó A, Rey MJ, Rábano A, Blesa R, Gómez-Isla T, Valdivieso F, de Pedro-Cuesta J, Ferrer I, Calero M
PLoS One. 2011
PubMed ID: 21799773
A polymorphism in the regulatory region of PRNP is associated with increased risk of sporadic Creutzfeldt-Jakob disease.
Sanchez-Juan P, Bishop MT, Croes EA, Knight RS, Will RG, van Duijn CM, Manson JC
BMC Med Genet. 2011
PubMed ID: 21600043
Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction.
Quaglio E, Restelli E, Garofoli A, Dossena S, De Luigi A, Tagliavacca L, Imperiale D, Migheli A, Salmona M, Sitia R, Forloni G, Chiesa R
PLoS One. 2011
PubMed ID: 21559407
Dynamic diagnosis of familial prion diseases supports the β2-α2 loop as a universal interference target.
Meli M, Gasset M, Colombo G
PLoS One. 2011
PubMed ID: 21552571
Prion protein expression regulates embryonic stem cell pluripotency and differentiation.
Miranda A, Pericuesta E, Ramírez MÁ, Gutierrez-Adan A
PLoS One. 2011
PubMed ID: 21483752
Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction.
Thellung S, Corsaro A, Villa V, Simi A, Vella S, Pagano A, Florio T
Cell Death Dis. 2011
PubMed ID: 21451573
Familial CJD associated PrP mutants within transmembrane region induced Ctm-PrP retention in ER and triggered apoptosis by ER stress in SH-SY5Y cells.
Wang X, Shi Q, Xu K, Gao C, Chen C, Li XL, Wang GR, Tian C, Han J, Dong XP
PLoS One. 2011
PubMed ID: 21298055
PSEN1 and PRNP gene mutations: co-occurrence makes onset very early in a family with FTD phenotype.
Bernardi L, Anfossi M, Geracitano S, Cola R, Puccio G, Curcio SA, Frangipane F, Mirabelli M, Clodomiro A, Di Lorenzo R, Smirne N, Maletta R, Iapaolo D, Bruni AC
J Alzheimers Dis. 2011
PubMed ID: 21297264
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Phenotypic variability of sporadic human prion disease and its molecular basis: past, present, and future.
Parchi P, Strammiello R, Giese A, Kretzschmar H
Acta Neuropathol. 2011
PubMed ID: 21107851
Molecular biology and pathology of prion strains in sporadic human prion diseases.
Gambetti P, Cali I, Notari S, Kong Q, Zou WQ, Surewicz WK
Acta Neuropathol. 2011
PubMed ID: 21058033
Expression and knockdown of cellular prion protein (PrPC) in differentiating mouse embryonic stem cells.
Peralta OA, Huckle WR, Eyestone WH
Differentiation. 2011
PubMed ID: 20926176
Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain.
Beraldo FH, Arantes CP, Santos TG, Machado CF, Roffe M, Hajj GN, Lee KS, Magalhães AC, Caetano FA, Mancini GL, Lopes MH, Américo TA, Magdesian MH, Ferguson SS, Linden R, Prado MA, Martins VR
FASEB J. 2011
PubMed ID: 20876210
Molecular pathology of human prion disease.
Wadsworth JD, Collinge J
Acta Neuropathol. 2011
PubMed ID: 20694796
Genetic Creutzfeldt-Jakob disease associated with the E200K mutation: characterization of a complex proteinopathy.
Kovacs GG, Seguin J, Quadrio I, Höftberger R, Kapás I, Streichenberger N, Biacabe AG, Meyronet D, Sciot R, Vandenberghe R, Majtenyi K, László L, Ströbel T, Budka H, Perret-Liaudet A
Acta Neuropathol. 2011
PubMed ID: 20593190
Tau, prions and Aβ: the triad of neurodegeneration.
Reiniger L, Lukic A, Linehan J, Rudge P, Collinge J, Mead S, Brandner S
Acta Neuropathol. 2011
PubMed ID: 20473510
A novel seven-octapeptide repeat insertion in the prion protein gene (PRNP) in a Dutch pedigree with Gerstmann-Sträussler-Scheinker disease phenotype: comparison with similar cases from the literature.
Jansen C, Voet W, Head MW, Parchi P, Yull H, Verrips A, Wesseling P, Meulstee J, Baas F, van Gool WA, Ironside JW, Rozemuller AJ
Acta Neuropathol. 2011
PubMed ID: 20198483
Pathogenic mutations in the hydrophobic core of the human prion protein can promote structural instability and misfolding.
van der Kamp MW, Daggett V
J Mol Biol. 2010
PubMed ID: 20932979
Pathologic evidence that the T188R mutation in PRNP is associated with prion disease.
Tartaglia MC, Thai JN, See T, Kuo A, Harbaugh R, Raudabaugh B, Cali I, Sattavat M, Sanchez H, DeArmond SJ, Geschwind MD
J Neuropathol Exp Neurol. 2010
PubMed ID: 21107135
Expression of prion gene and presence of prion protein during development of mouse molar tooth germ.
Khan QE, Press CM, Sehic A, Landin MA, Risnes S, Osmundsen H
Eur J Oral Sci. 2010
PubMed ID: 21083616
Exposure of hydrophobic core in human prion protein pathogenic mutant H187R.
Zhong L
J Biomol Struct Dyn. 2010
PubMed ID: 20919751
Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation.
Hughes MM, Field RH, Perry VH, Murray CL, Cunningham C
Glia. 2010
PubMed ID: 20878768
Elevated phosphorylated tau pT-181 in a possible PRNP codon 129 MV vCJD case.
Green AJ, Andrews MM, Bishop MT, McKenzie JM, McCord Y, Pennington C, Chohan G, Knight RS
J Neurol Neurosurg Psychiatry. 2010
PubMed ID: 20562404
Diverse effects on the native β-sheet of the human prion protein due to disease-associated mutations.
Chen W, van der Kamp MW, Daggett V
Biochemistry. 2010
PubMed ID: 20949975
Prion-like aggregates: infectious agents in human disease.
Westermark GT, Westermark P
Trends Mol Med. 2010
PubMed ID: 20870462
Anionic phospholipid interactions of the prion protein N terminus are minimally perturbing and not driven solely by the octapeptide repeat domain.
Boland MP, Hatty CR, Separovic F, Hill AF, Tew DJ, Barnham KJ, Haigh CL, James M, Masters CL, Collins SJ
J Biol Chem. 2010
PubMed ID: 20679345
The H187R mutation of the human prion protein induces conversion of recombinant prion protein to the PrP(Sc)-like form.
Hosszu LL, Tattum MH, Jones S, Trevitt CR, Wells MA, Waltho JP, Collinge J, Jackson GS, Clarke AR
Biochemistry. 2010
PubMed ID: 20718410
Influence of pH on the human prion protein: insights into the early steps of misfolding.
van der Kamp MW, Daggett V
Biophys J. 2010
PubMed ID: 20923664
Proteomic consequences of expression and pathological conversion of the prion protein in inducible neuroblastoma N2a cells.
Provansal M, Roche S, Pastore M, Casanova D, Belondrade M, Alais S, Leblanc P, Windl O, Lehmann S
Prion. 2010
PubMed ID: 20930564
Enhancement of phagocytotic activity by prion protein in PrP-deficient macrophage cells.
Uraki R, Sakudo A, Ando S, Kitani H, Onodera T
Int J Mol Med. 2010
PubMed ID: 20818492
PrPC, the cellular isoform of the human prion protein, is a novel biomarker of HIV-associated neurocognitive impairment and mediates neuroinflammation.
Roberts TK, Eugenin EA, Morgello S, Clements JE, Zink MC, Berman JW
Am J Pathol. 2010
PubMed ID: 20724601
Cellular prion protein promotes regeneration of adult muscle tissue.
Stella R, Massimino ML, Sandri M, Sorgato MC, Bertoli A
Mol Cell Biol. 2010
PubMed ID: 20679477
Calnexin inhibits thermal aggregation and neurotoxicity of prion protein.
Wang W, Chen R, Luo K, Wu D, Huang L, Huang T, Xiao G
J Cell Biochem. 2010
PubMed ID: 20506117
Characterization of the role of dendritic cells in prion transfer to primary neurons.
Langevin C, Gousset K, Costanzo M, Richard-Le Goff O, Zurzolo C
Biochem J. 2010
PubMed ID: 20670217
Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese.
Wang F, Shu C, Jia L, Zuo X, Zhang Y, Zhou A, Qin W, Song H, Wei C, Zhang F, Hong Z, Tang M, Wang DM, Jia J
Neurobiol Aging. 2010
PubMed ID: 20880607
Divergent heparin-induced fibrillation pathways of a prion amyloidogenic determinant.
Bazar E, Jelinek R
Chembiochem. 2010
PubMed ID: 20799315
Crystallographic studies of prion protein (PrP) segments suggest how structural changes encoded by polymorphism at residue 129 modulate susceptibility to human prion disease.
Apostol MI, Sawaya MR, Cascio D, Eisenberg D
J Biol Chem. 2010
PubMed ID: 20685658
Pro-prion binds filamin A, facilitating its interaction with integrin beta1, and contributes to melanomagenesis.
Li C, Yu S, Nakamura F, Pentikäinen OT, Singh N, Yin S, Xin W, Sy MS
J Biol Chem. 2010
PubMed ID: 20650901
Characterization of discontinuous epitope of prion protein recognized by the monoclonal antibody T2.
Sasamori E, Suzuki S, Kato M, Tagawa Y, Hanyu Y
Arch Biochem Biophys. 2010
PubMed ID: 20599662
Cellular prion protein overexpression disturbs cellular homeostasis in SH-SY5Y neuroblastoma cells but does not alter p53 expression: a proteomic study.
Weiss E, Ramljak S, Asif AR, Ciesielczyk B, Schmitz M, Gawinecka J, Schulz-Schaeffer W, Behrens C, Zerr I
Neuroscience. 2010
PubMed ID: 20547212
Analyses of shared genetic factors between asthma and obesity in children.
Melén E, Himes BE, Brehm JM, Boutaoui N, Klanderman BJ, Sylvia JS, Lasky-Su J
J Allergy Clin Immunol. 2010
PubMed ID: 20816195
The hydrophobic core region governs mutant prion protein aggregation and intracellular retention.
Biasini E, Tapella L, Restelli E, Pozzoli M, Massignan T, Chiesa R
Biochem J. 2010
PubMed ID: 20626348
Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues.
Chen S, Yadav SP, Surewicz WK
J Biol Chem. 2010
PubMed ID: 20576610
Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells.
Solomon IH, Huettner JE, Harris DA
J Biol Chem. 2010
PubMed ID: 20573963
Prion Protein Codon 129 Polymorphism Modifies Age at Onset of Frontotemporal Dementia With the C.709-1G>A Progranulin Mutation.
Moreno F, Alzualde A, Camblor PM, Barandiaran M, Van Deerlin VM, Gabilondo A, Martí Massó JF, de Munain AL, Indakoetxea B
Alzheimer Dis Assoc Disord. 2010
PubMed ID: 20711061
The prion protein as a receptor for amyloid-beta.
Kessels HW, Nguyen LN, Nabavi S, Malinow R
Nature. 2010
PubMed ID: 20703260
Spontaneous generation of mammalian prions.
Edgeworth JA, Gros N, Alden J, Joiner S, Wadsworth JD, Linehan J, Brandner S, Jackson GS, Weissmann C, Collinge J
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20660771
The unfolded state of the murine prion protein and properties of single-point mutants related to human prion diseases.
Gerum C, Schlepckow K, Schwalbe H
J Mol Biol. 2010
PubMed ID: 20541558
Analysis of single nucleotide polymorphisms of PRNP gene in twenty-four ethnic groups of India.
Sengupta M, Chakraborty A, Indian Genome Variation Consortium, Ray K
J Genet. 2010
PubMed ID: 20861579
A novel PRNP Y218N mutation in Gerstmann-Sträussler-Scheinker disease with neurofibrillary degeneration.
Alzualde A, Indakoetxea B, Ferrer I, Moreno F, Barandiaran M, Gorostidi A, Estanga A, Ruiz I, Calero M, van Leeuwen FW, Atares B, Juste R, Rodriguez-Martínez AB, López de Munain A
J Neuropathol Exp Neurol. 2010
PubMed ID: 20613639
Ionic mechanisms of action of prion protein fragment PrP(106-126) in rat basal forebrain neurons.
Alier K, Li Z, Mactavish D, Westaway D, Jhamandas JH
J Neurosci Res. 2010
PubMed ID: 20175205
Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR.
Roffé M, Beraldo FH, Bester R, Nunziante M, Bach C, Mancini G, Gilch S, Vorberg I, Castilho BA, Martins VR, Hajj GN
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20615969
Emergence and natural selection of drug-resistant prions.
Shorter J
Mol Biosyst. 2010
PubMed ID: 20422111
Horse prion protein NMR structure and comparisons with related variants of the mouse prion protein.
Pérez DR, Damberger FF, Wüthrich K
J Mol Biol. 2010
PubMed ID: 20460128
Cellular form of prion protein inhibits Reelin-mediated shedding of Caspr from the neuronal cell surface to potentiate Caspr-mediated inhibition of neurite outgrowth.
Devanathan V, Jakovcevski I, Santuccione A, Li S, Lee HJ, Peles E, Leshchyns'ka I, Sytnyk V, Schachner M
J Neurosci. 2010
PubMed ID: 20610764
Prion fibrillization is mediated by a native structural element that comprises helices H2 and H3.
Adrover M, Pauwels K, Prigent S, de Chiara C, Xu Z, Chapuis C, Pastore A, Rezaei H
J Biol Chem. 2010
PubMed ID: 20375014
Polymorphisms of the prion protein gene (PRNP) in a Serbian population.
Dimitrijević R, Cadez I, Keckarević-Marković M, Keckarević D, Kecmanović M, Dobricić V, Savić-Pavićević D, Brajusković G, Romac S
Int J Neurosci. 2010
PubMed ID: 20583902
PRNP allelic series from 19 years of prion protein gene sequencing at the MRC Prion Unit.
Beck JA, Poulter M, Campbell TA, Adamson G, Uphill JB, Guerreiro R, Jackson GS, Stevens JC, Manji H, Collinge J, Mead S
Hum Mutat. 2010
PubMed ID: 20583301
Prion protein expression and the M129V polymorphism of the PRNP gene in patients with colorectal cancer.
Antonacopoulou AG, Palli M, Marousi S, Dimitrakopoulos FI, Kyriakopoulou U, Tsamandas AC, Scopa CD, Papavassiliou AG, Kalofonos HP
Mol Carcinog. 2010
PubMed ID: 20564346
Interaction of the prion protein fragment PrP 185-206 with biological membranes: effect on membrane permeability.
Sonkina S, Tukhfatullina II, Benseny-Cases N, Ionov M, Bryszewska M, Salakhutdinov BA, Cladera J
J Pept Sci. 2010
PubMed ID: 20552563
Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
Johnson AD, Yanek LR, Chen MH, Faraday N, Larson MG, Tofler G, Lin SJ, Kraja AT, Province MA, Yang Q, Becker DM, O'Donnell CJ, Becker LC
Nat Genet. 2010
PubMed ID: 20526338
Highly polar environments catalyze the unfolding of PrP C helix 1.
Lingenheil M, Denschlag R, Tavan P
Eur Biophys J. 2010
PubMed ID: 20049591
Defining sporadic Creutzfeldt-Jakob disease strains and their transmission properties.
Bishop MT, Will RG, Manson JC
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20547859
Conservation of a glycine-rich region in the prion protein is required for uptake of prion infectivity.
Harrison CF, Lawson VA, Coleman BM, Kim YS, Masters CL, Cappai R, Barnham KJ, Hill AF
J Biol Chem. 2010
PubMed ID: 20356832
Copper (II) promotes the formation of soluble neurotoxic PrP oligomers in acidic environment.
Wu D, Zhang W, Luo Q, Luo K, Huang L, Wang W, Huang T, Chen R, Lin Y, Pang D, Xiao G
J Cell Biochem. 2010
PubMed ID: 20564047
Structural properties and dynamic behavior of nonfibrillar oligomers formed by PrP(106-126).
Walsh P, Neudecker P, Sharpe S
J Am Chem Soc. 2010
PubMed ID: 20465257
Codon 129 polymorphism and the E200K mutation do not affect the cellular prion protein isoform composition in the cerebrospinal fluid from patients with Creutzfeldt-Jakob disease.
Schmitz M, Schlomm M, Hasan B, Beekes M, Mitrova E, Korth C, Breil A, Carimalo J, Gawinecka J, Varges D, Zerr I
Eur J Neurosci. 2010
PubMed ID: 20529115
A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death.
Christensen HM, Dikranian K, Li A, Baysac KC, Walls KC, Olney JW, Roth KA, Harris DA
Am J Pathol. 2010
PubMed ID: 20472884
Neurodevelopmental expression and localization of the cellular prion protein in the central nervous system of the mouse.
Benvegnù S, Poggiolini I, Legname G
J Comp Neurol. 2010
PubMed ID: 20394048
Creutzfeldt-Jakob disease with PRNP G114V mutation in a Chinese family.
Liu Z, Jia L, Piao Y, Lu D, Wang F, Lv H, Lu Y, Jia J
Acta Neurol Scand. 2010
PubMed ID: 20028338
Transient expressions of doppel and its structural analog prionDelta32-121 in SH-SY5Y cells caused cytotoxicity possibly by triggering similar apoptosis pathway.
Xu K, Wang X, Tian C, Shi S, Wang GR, Shi Q, Li P, Zhou RM, Jiang HY, Chu YL, Dong XP
Mol Biol Rep. 2010
PubMed ID: 19728151
Mapping the interaction site of prion protein and Sho.
Jiayu W, Zhu H, Ming X, Xiong W, Songbo W, Bocui S, Wensen L, Jiping L, Keying M, Zhongyi L, Hongwei G
Mol Biol Rep. 2010
PubMed ID: 19685161
Altered expression of type 1 inositol 1,4,5-trisphosphate receptor in the Ngsk Prnp deficient mice.
Lee HP, Choi JK, Shin HY, Jeon YC, Jeong BH, Lee HG, Kim JI, Choi EK, Carp RI, Kim YS
Neuroscience. 2010
PubMed ID: 20219645
Memory impairment in transgenic Alzheimer mice requires cellular prion protein.
Gimbel DA, Nygaard HB, Coffey EE, Gunther EC, Laurén J, Gimbel ZA, Strittmatter SM
J Neurosci. 2010
PubMed ID: 20445063
Spreading of prions from the immune to the peripheral nervous system: a potential implication of dendritic cells.
Dorban G, Defaweux V, Heinen E, Antoine N
Histochem Cell Biol. 2010
PubMed ID: 20238136
Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans.
Bizat N, Peyrin JM, Haïk S, Cochois V, Beaudry P, Laplanche JL, Néri C
J Neurosci. 2010
PubMed ID: 20392961
A novel copper(II) coordination at His186 in full-length murine prion protein.
Watanabe Y, Hiraoka W, Igarashi M, Ito K, Shimoyama Y, Horiuchi M, Yamamori T, Yasui H, Kuwabara M, Inagaki F, Inanami O
Biochem Biophys Res Commun. 2010
PubMed ID: 20206606
Rare E196K mutation in the PRNP gene of a patient exhibiting behavioral abnormalities.
Béjot Y, Osseby GV, Caillier M, Moreau T, Laplanche JL, Giroud M
Clin Neurol Neurosurg. 2010
PubMed ID: 20005032
Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway.
Massignan T, Biasini E, Lauranzano E, Veglianese P, Pignataro M, Fioriti L, Harris DA, Salmona M, Chiesa R, Bonetto V
Mol Cell Proteomics. 2010
PubMed ID: 19996123
Low density subcellular fractions enhance disease-specific prion protein misfolding.
Graham JF, Agarwal S, Kurian D, Kirby L, Pinheiro TJ, Gill AC
J Biol Chem. 2010
PubMed ID: 20106973
Live cell fluorescence resonance energy transfer predicts an altered molecular association of heterologous PrPSc with PrPC.
Mallik S, Yang W, Norstrom EM, Mastrianni JA
J Biol Chem. 2010
PubMed ID: 20086009
Microdeletions within the hydrophobic core region of cellular prion protein alter its topology and metabolism.
Lutz J, Brabeck C, Niemann HH, Kloz U, Korth C, Lingappa VR, Bürkle A
Biochem Biophys Res Commun. 2010
PubMed ID: 20138835
No evidence for prion protein gene locus multiplication in Creutzfeldt-Jakob disease.
Collins SJ, Schuur M, Boyd A, Lewis V, Klug GM, McGlade A, van Oosterhout A, Breedveld G, Oostra BA, Masters C, Van Duijn CM
Neurosci Lett. 2010
PubMed ID: 20105449
[M129V PRNP gene polymorphism in Castilla y León shows a similar distribution to other Spanish regions and other European countries]
Castellanos A, Pérez Prieto M, Castrodeza J, Mirón Canelo JA, González-Sarmiento R
Med Clin (Barc). 2010
PubMed ID: 20004419
A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.
Massignan T, Stewart RS, Biasini E, Solomon IH, Bonetto V, Chiesa R, Harris DA
J Biol Chem. 2010
PubMed ID: 19940127
A whole genome association study of mother-to-child transmission of HIV in Malawi.
Joubert BR, Lange EM, Franceschini N, Mwapasa V, North KE, Meshnick SR, the NIAID Center for HIV/AIDS Vaccine Immunology
Genome Med. 2010
PubMed ID: 20487506
Axonal prion protein is required for peripheral myelin maintenance.
Bremer J, Baumann F, Tiberi C, Wessig C, Fischer H, Schwarz P, Steele AD, Toyka KV, Nave KA, Weis J, Aguzzi A
Nat Neurosci. 2010
PubMed ID: 20098419
Neuroprotective function of cellular prion protein in a mouse model of amyotrophic lateral sclerosis.
Steinacker P, Hawlik A, Lehnert S, Jahn O, Meier S, Görz E, Braunstein KE, Krzovska M, Schwalenstöcker B, Jesse S, Pröpper C, Böckers T, Ludolph A, Otto M
Am J Pathol. 2010
PubMed ID: 20075202
PET of brain prion protein amyloid in Gerstmann-Sträussler-Scheinker disease.
Kepe V, Ghetti B, Farlow MR, Bresjanac M, Miller K, Huang SC, Wong KP, Murrell JR, Piccardo P, Epperson F, Repovs G, Smid LM, Petric A, Siddarth P, Liu J, Satyamurthy N, Small GW, Barrio JR
Brain Pathol. 2010
PubMed ID: 19725833
Generating a prion with bacterially expressed recombinant prion protein.
Wang F, Wang X, Yuan CG, Ma J
Science. 2010
PubMed ID: 20110469
Inverse correlation of thermal lability and conversion efficiency for five prion protein polymorphic variants.
Kirby L, Agarwal S, Graham JF, Goldmann W, Gill AC
Biochemistry. 2010
PubMed ID: 20085368
Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein.
Balducci C, Beeg M, Stravalaci M, Bastone A, Sclip A, Biasini E, Tapella L, Colombo L, Manzoni C, Borsello T, Chiesa R, Gobbi M, Salmona M, Forloni G
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133875
Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling.
Hu W, Nessler S, Hemmer B, Eagar TN, Kane LP, Leliveld SR, Müller-Schiffmann A, Gocke AR, Lovett-Racke A, Ben LH, Hussain RZ, Breil A, Elliott JL, Puttaparthi K, Cravens PD, Singh MP, Petsch B, Stitz L, Racke MK, Korth C, Stüve O
Brain. 2010
PubMed ID: 20145049
Prion protein amyloidosis with divergent phenotype associated with two novel nonsense mutations in PRNP.
Jansen C, Parchi P, Capellari S, Vermeij AJ, Corrado P, Baas F, Strammiello R, van Gool WA, van Swieten JC, Rozemuller AJ
Acta Neuropathol. 2010
PubMed ID: 19911184
A genome-wide association study on African-ancestry populations for asthma.
Mathias RA, Grant AV, Rafaels N, Hand T, Gao L, Vergara C, Tsai YJ, Yang M, Campbell M, Foster C, Gao P, Togias A, Hansel NN, Diette G, Adkinson NF, Liu MC, Faruque M, Dunston GM, Watson HR, Bracken MB, Hoh J, Maul P, Maul T, Jedlicka AE, Murray T, Hetmanski JB, Ashworth R, Ongaco CM, Hetrick KN, Doheny KF, Pugh EW, Rotimi CN, Ford J, Eng C, Burchard EG, Sleiman PM, Hakonarson H, Forno E, Raby BA, Weiss ST, Scott AF, Kabesch M, Liang L, Abecasis G, Moffatt MF, Cookson WO, Ruczinski I, Beaty TH, Barnes KC
J Allergy Clin Immunol. 2010
PubMed ID: 19910028
Transmissible spongiform encephalopathies with P102L mutation of PRNP manifesting different phenotypes: clinical, neuroimaging, and electrophysiological studies in Chinese kindred in Taiwan.
Chi NF, Lee YC, Lu YC, Wu HM, Soong BW
J Neurol. 2010
PubMed ID: 19696976
Amino acid conditions near the GPI anchor attachment site of prion protein for the conversion and the GPI anchoring.
Hizume M, Kobayashi A, Mizusawa H, Kitamoto T
Biochem Biophys Res Commun. 2010
PubMed ID: 20040362
Rhythmic pupillary oscillation in Creutzfeldt-Jakob disease associated with the Glu/Lys mutation of prion protein codon 200.
Nagasaka K, Ohta E, Nagasaka T, Togashi S, Miwa M, Nakamura Y, Shindo K, Shiozawa Z
Mov Disord. 2010
PubMed ID: 20077484
Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4.
Jen A, Parkyn CJ, Mootoosamy RC, Ford MJ, Warley A, Liu Q, Bu G, Baskakov IV, Moestrup S, McGuinness L, Emptage N, Morris RJ
J Cell Sci. 2010
PubMed ID: 20048341
Doppel and PrPC co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cells.
Caputo A, Sarnataro D, Campana V, Costanzo M, Negro A, Sorgato MC, Zurzolo C
Biochem J. 2010
PubMed ID: 19888917
Conformational diversity in prion protein variants influences intermolecular beta-sheet formation.
Lee S, Antony L, Hartmann R, Knaus KJ, Surewicz K, Surewicz WK, Yee VC
EMBO J. 2010
PubMed ID: 19927125
Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress.
Torres M, Castillo K, Armisén R, Stutzin A, Soto C, Hetz C
PLoS One. 2010
PubMed ID: 21209925
D178N, 129Val and N171S, 129Val genotype in a family with Creutzfeldt-Jakob disease.
Appleby BS, Appleby KK, Hall RC, Wallin MT
Dement Geriatr Cogn Disord. 2010
PubMed ID: 21071944
Prion protein is reduced in aging and in sporadic but not in familial Alzheimer's disease.
Whitehouse IJ, Jackson C, Turner AJ, Hooper NM
J Alzheimers Dis. 2010
PubMed ID: 20930299
Glycosaminoglycan sulphation affects the seeded misfolding of a mutant prion protein.
Lawson VA, Lumicisi B, Welton J, Machalek D, Gouramanis K, Klemm HM, Stewart JD, Masters CL, Hoke DE, Collins SJ, Hill AF
PLoS One. 2010
PubMed ID: 20808809
NMR structure of the human prion protein with the pathological Q212P mutation reveals unique structural features.
Ilc G, Giachin G, Jaremko M, Jaremko Ł, Benetti F, Plavec J, Zhukov I, Legname G
PLoS One. 2010
PubMed ID: 20661422
Brain transcriptional stability upon prion protein-encoding gene invalidation in zygotic or adult mouse.
Chadi S, Young R, Le Guillou S, Tilly G, Bitton F, Martin-Magniette ML, Soubigou-Taconnat L, Balzergue S, Vilotte M, Peyre C, Passet B, Béringue V, Renou JP, Le Provost F, Laude H, Vilotte JL
BMC Genomics. 2010
PubMed ID: 20649983
Oxidation of Helix-3 methionines precedes the formation of PK resistant PrP.
Canello T, Frid K, Gabizon R, Lisa S, Friedler A, Moskovitz J, Gasset M, Gabizon R
PLoS Pathog. 2010
PubMed ID: 20625387
Lack of association between PRNP M129V polymorphism and multiple sclerosis, mild cognitive impairment, alcoholism and schizophrenia in a Korean population.
Choi IG, Woo SI, Kim HJ, Kim DJ, Park BL, Cheong HS, Pasaje CF, Park TJ, Bae JS, Chai YG, Shin HD
Dis Markers. 2010
PubMed ID: 20592456
Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
Shulman JM, Chibnik LB, Aubin C, Schneider JA, Bennett DA, De Jager PL
PLoS One. 2010
PubMed ID: 20574532
Interactions between PrP(c) and other ligands with the 37-kDa/67-kDa laminin receptor.
Mbazima V, Da Costa Dias B, Omar A, Jovanovic K, Weiss SF
Front Biosci. 2010
PubMed ID: 20515747
Copper, endoproteolytic processing of the prion protein and cell signalling.
Haigh CL, Marom SY, Collins SJ
Front Biosci. 2010
PubMed ID: 20515743
Cellular roles of the prion protein in association with reggie/flotillin microdomains.
Solis GP, Malaga-Trillo E, Plattner H, Stuermer CA
Front Biosci. 2010
PubMed ID: 20515742
Clinical features of rapidly progressive Alzheimer's disease.
Schmidt C, Redyk K, Meissner B, Krack L, von Ahsen N, Roeber S, Kretzschmar H, Zerr I
Dement Geriatr Cogn Disord. 2010
PubMed ID: 20453509
Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.
Laumet G, Chouraki V, Grenier-Boley B, Legry V, Heath S, Zelenika D, Fievet N, Hannequin D, Delepine M, Pasquier F, Hanon O, Brice A, Epelbaum J, Berr C, Dartigues JF, Tzourio C, Campion D, Lathrop M, Bertram L, Amouyel P, Lambert JC
J Alzheimers Dis. 2010
PubMed ID: 20413850
Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoring.
Chesebro B, Race B, Meade-White K, Lacasse R, Race R, Klingeborn M, Striebel J, Dorward D, McGovern G, Jeffrey M
PLoS Pathog. 2010
PubMed ID: 20221436
The octarepeat region of the prion protein is conformationally altered in PrP(Sc).
Yam AY, Gao CM, Wang X, Wu P, Peretz D
PLoS One. 2010
PubMed ID: 20195363
Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations.
Oliveira-Martins JB, Yusa S, Calella AM, Bridel C, Baumann F, Dametto P, Aguzzi A
PLoS One. 2010
PubMed ID: 20161712
Aptamers to explore prion protein interactions with nucleic acids.
Marc D
Front Biosci. 2010
PubMed ID: 20036833
PrP interactions with nucleic acids and glycosaminoglycans in function and disease.
Silva JL, Gomes MP, Vieira TC, Cordeiro Y
Front Biosci. 2010
PubMed ID: 20036811
Variant CJD in an individual heterozygous for PRNP codon 129.
Kaski D, Mead S, Hyare H, Cooper S, Jampana R, Overell J, Knight R, Collinge J, Rudge P
Lancet. 2009
PubMed ID: 20109837
The alpha-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivo.
Guillot-Sestier MV, Sunyach C, Druon C, Scarzello S, Checler F
J Biol Chem. 2009
PubMed ID: 19850936
Cellular prion protein modulates age-related behavioral and neurochemical alterations in mice.
Rial D, Duarte FS, Xikota JC, Schmitz AE, Dafré AL, Figueiredo CP, Walz R, Prediger RD
Neuroscience. 2009
PubMed ID: 19747526
Dramatic reduction of PrP C level and glycosylation in peripheral nerves following PrP knock-out from Schwann cells does not prevent transmissible spongiform encephalopathy neuroinvasion.
Bradford BM, Tuzi NL, Feltri ML, McCorquodale C, Cancellotti E, Manson JC
J Neurosci. 2009
PubMed ID: 20007469
Inherited Creutzfeldt-Jakob disease in a Dutch patient with a novel five octapeptide repeat insertion and unusual cerebellar morphology.
Jansen C, van Swieten JC, Capellari S, Strammiello R, Parchi P, Rozemuller AJ
J Neurol Neurosurg Psychiatry. 2009
PubMed ID: 19917818
Immune cell types involved in early uptake and transport of recombinant mouse prion protein in Peyer's patches of calves.
Lwin S, Inoshima Y, Atoji Y, Ueno H, Ishiguro N
Cell Tissue Res. 2009
PubMed ID: 19834742
Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation.
Gilch S, Bach C, Lutzny G, Vorberg I, Schätzl HM
Cell Mol Life Sci. 2009
PubMed ID: 19823766
Reciprocal remodeling upon binding of the prion protein to its signaling partner hop/STI1.
Romano SA, Cordeiro Y, Lima LM, Lopes MH, Silva JL, Foguel D, Linden R
FASEB J. 2009
PubMed ID: 19703931
Generation of monoclonal antibody that distinguishes PrPSc from PrPC and neutralizes prion infectivity.
Horiuchi M, Karino A, Furuoka H, Ishiguro N, Kimura K, Shinagawa M
Virology. 2009
PubMed ID: 19766283
Developmental expression of prion protein and its ligands stress-inducible protein 1 and vitronectin.
Hajj GN, Santos TG, Cook ZS, Martins VR
J Comp Neurol. 2009
PubMed ID: 19760599
A novel protective prion protein variant that colocalizes with kuru exposure.
Mead S, Whitfield J, Poulter M, Shah P, Uphill J, Campbell T, Al-Dujaily H, Hummerich H, Beck J, Mein CA, Verzilli C, Whittaker J, Alpers MP, Collinge J
N Engl J Med. 2009
PubMed ID: 19923577
The role of glycophosphatidylinositol anchor in the amplification of the scrapie isoform of prion protein in vitro.
Kim JI, Surewicz K, Gambetti P, Surewicz WK
FEBS Lett. 2009
PubMed ID: 19854187
Adoptive transfer of T lymphocytes sensitized against the prion protein attenuates prion invasion in scrapie-infected mice.
Gourdain P, Grégoire S, Iken S, Bachy V, Dorban G, Chaigneau T, Debiec H, Bergot AS, Renault I, Aucouturier P, Carnaud C
J Immunol. 2009
PubMed ID: 19846876
Clathrin-independent internalization of normal cellular prion protein in neuroblastoma cells is associated with the Arf6 pathway.
Kang YS, Zhao X, Lovaas J, Eisenberg E, Greene LE
J Cell Sci. 2009
PubMed ID: 19843586
Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3.
Boy J, Schmidt T, Wolburg H, Mack A, Nuber S, Böttcher M, Schmitt I, Holzmann C, Zimmermann F, Servadio A, Riess O
Hum Mol Genet. 2009
PubMed ID: 19666958
Structural insights into alternate aggregated prion protein forms.
Polano M, Bek A, Benetti F, Lazzarino M, Legname G
J Mol Biol. 2009
PubMed ID: 19720066
Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells.
Bach C, Gilch S, Rost R, Greenwood AD, Horsch M, Hajj GN, Brodesser S, Facius A, Schädler S, Sandhoff K, Beckers J, Leib-Mösch C, Schätzl HM, Vorberg I
J Biol Chem. 2009
PubMed ID: 19748890
Aggregation and amyloid fibril formation induced by chemical dimerization of recombinant prion protein in physiological-like conditions.
Roostaee A, Côté S, Roucou X
J Biol Chem. 2009
PubMed ID: 19710507
No replication of genetic association between candidate polymorphisms and Alzheimer's disease.
Cousin E, Macé S, Rocher C, Dib C, Muzard G, Hannequin D, Pradier L, Deleuze JF, Génin E, Brice A, Campion D
Neurobiol Aging. 2009
PubMed ID: 19889475
Spatial correlations between the vacuolation, prion protein (PrPsc) deposits and the cerebral blood vessels in sporadic Creutzfeldt-Jakob disease.
Armstrong RA
Curr Neurovasc Res. 2009
PubMed ID: 19807656
Analysis of protein levels of 24 cytokines in scrapie agent-infected brain and glial cell cultures from mice differing in prion protein expression levels.
Tribouillard-Tanvier D, Striebel JF, Peterson KE, Chesebro B
J Virol. 2009
PubMed ID: 19710140
Differential solubility of prions is associated in manifold phenotypes.
Kuczius T, Karch H, Groschup MH
Mol Cell Neurosci. 2009
PubMed ID: 19607920
Function of PrPC (1-OPRD) in biological activities of gastric cancer cell lines.
Liang J, Wang J, Luo G, Pan Y, Wang X, Guo C, Zhang D, Yin F, Zhang X, Liu J, Wang J, Guo X, Wu K, Fan D
J Cell Mol Med. 2009
PubMed ID: 19210573
Enhancement of protein misfolding cyclic amplification by using concentrated cellular prion protein source.
Mays CE, Titlow W, Seward T, Telling GC, Ryou C
Biochem Biophys Res Commun. 2009
PubMed ID: 19664595
Natural and synthetic prion structure from X-ray fiber diffraction.
Wille H, Bian W, McDonald M, Kendall A, Colby DW, Bloch L, Ollesch J, Borovinskiy AL, Cohen FE, Prusiner SB, Stubbs G
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19805070
The prion or the related Shadoo protein is required for early mouse embryogenesis.
Young R, Passet B, Vilotte M, Cribiu EP, Béringue V, Le Provost F, Laude H, Vilotte JL
FEBS Lett. 2009
PubMed ID: 19766638
Codistribution of amyloid beta plaques and spongiform degeneration in familial Creutzfeldt-Jakob disease with the E200K-129M haplotype.
Ghoshal N, Cali I, Perrin RJ, Josephson SA, Sun N, Gambetti P, Morris JC
Arch Neurol. 2009
PubMed ID: 19822779
Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease: its effect on the phenotype and prion-type characteristics.
Cali I, Castellani R, Alshekhlee A, Cohen Y, Blevins J, Yuan J, Langeveld JP, Parchi P, Safar JG, Zou WQ, Gambetti P
Brain. 2009
PubMed ID: 19734292
Binding of TCA to the prion protein: mechanism, implication for therapy, and application as probe for complex formation of bio-macromolecules.
Mangels C, Frank AO, Ziegler J, Klingenstein R, Schweimer K, Willbold D, Korth C, Rösch P, Schwarzinger S
J Biomol Struct Dyn. 2009
PubMed ID: 19583442
New insights into cellular prion protein (PrPc) functions: the "ying and yang" of a relevant protein.
Nicolas O, Gavín R, del Río JA
Brain Res Rev. 2009
PubMed ID: 19523487
Prion protein and its ligand stress inducible protein 1 regulate astrocyte development.
Arantes C, Nomizo R, Lopes MH, Hajj GN, Lima FR, Martins VR
Glia. 2009
PubMed ID: 19243016
The unfolding of the prion protein sheds light on the mechanisms of prion susceptibility and species barrier.
Robinson PJ, Pinheiro TJ
Biochemistry. 2009
PubMed ID: 19655812
Characterization of a specific interaction between ADAM23 and cellular prion protein.
Costa MD, Paludo KS, Klassen G, Lopes MH, Mercadante AF, Martins VR, Camargo AA, Nakao LS, Zanata SM
Neurosci Lett. 2009
PubMed ID: 19477226
Prion protein with an insertional mutation accumulates on axonal and dendritic plasmalemma and is associated with distinctive ultrastructural changes.
Jeffrey M, Goodsir C, McGovern G, Barmada SJ, Medrano AZ, Harris DA
Am J Pathol. 2009
PubMed ID: 19700753
Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer.
Li C, Yu S, Nakamura F, Yin S, Xu J, Petrolla AA, Singh N, Tartakoff A, Abbott DW, Xin W, Sy MS
J Clin Invest. 2009
PubMed ID: 19690385
Prion proteins with pathogenic and protective mutations show similar structure and dynamics.
Bae SH, Legname G, Serban A, Prusiner SB, Wright PE, Dyson HJ
Biochemistry. 2009
PubMed ID: 19618915
PrPC-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site.
Haigh CL, Lewis VA, Vella LJ, Masters CL, Hill AF, Lawson VA, Collins SJ
Cell Res. 2009
PubMed ID: 19597535
Spongiform pathology in mouse CNS lacking 'neuropathy target esterase' and cellular prion protein.
Rosenbluth J, Schiff R, Lam P, Nuriel T, Chao MV
Neurobiol Dis. 2009
PubMed ID: 19524041
Development of oligomeric prion-protein aggregates in a mouse model of prion disease.
Sasaki K, Minaki H, Iwaki T
J Pathol. 2009
PubMed ID: 19479969
Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice.
Jackson WS, Borkowski AW, Faas H, Steele AD, King OD, Watson N, Jasanoff A, Lindquist S
Neuron. 2009
PubMed ID: 19709627
Conformational properties of beta-PrP.
Hosszu LL, Trevitt CR, Jones S, Batchelor M, Scott DJ, Jackson GS, Collinge J, Waltho JP, Clarke AR
J Biol Chem. 2009
PubMed ID: 19369250
A New Transgenic Mouse Model of Gerstmann-Straussler-Scheinker Syndrome Caused by the A117V Mutation of PRNP.
Yang W, Cook J, Rassbach B, Lemus A, DeArmond SJ, Mastrianni JA
J Neurosci. 2009
PubMed ID: 19675240
Loss of cerebellar granule neurons is associated with punctate but not with large focal deposits of prion protein in Creutzfeldt-Jakob disease.
Faucheux BA, Privat N, Brandel JP, Sazdovitch V, Laplanche JL, Maurage CA, Hauw JJ, Haïk S
J Neuropathol Exp Neurol. 2009
PubMed ID: 19606064
The consequences of pathogenic mutations to the human prion protein.
van der Kamp MW, Daggett V
Protein Eng Des Sel. 2009
PubMed ID: 19602567
Characterization of prion protein-enriched domains, isolated from rat cerebellar granule cells in culture.
Farina F, Botto L, Chinello C, Cunati D, Magni F, Masserini M, Palestini P
J Neurochem. 2009
PubMed ID: 19493159
Cellular prion protein coupling to TACE-dependent TNF-alpha shedding controls neurotransmitter catabolism in neuronal cells.
Pradines E, Loubet D, Mouillet-Richard S, Manivet P, Launay JM, Kellermann O, Schneider B
J Neurochem. 2009
PubMed ID: 19457070
Cytosolic prion protein induces apoptosis in human neuronal cell SH-SY5Y via mitochondrial disruption pathway.
Wang X, Dong CF, Shi Q, Shi S, Wang GR, Lei YJ, Xu K, An R, Chen JM, Jiang HY, Tian C, Gao C, Zhao YJ, Han J, Dong XP
BMB Rep. 2009
PubMed ID: 19643043
Phosphorylation of prion protein at serine 43 induces prion protein conformational change.
Giannopoulos PN, Robertson C, Jodoin J, Paudel H, Booth SA, LeBlanc AC
J Neurosci. 2009
PubMed ID: 19587281
The role of the prion protein membrane anchor in prion infection.
Priola SA, McNally KL
Prion. 2009
PubMed ID: 19786843
PrPc activation induces neurite outgrowth and differentiation in PC12 cells: role for caveolin-1 in the signal transduction pathway.
Pantera B, Bini C, Cirri P, Paoli P, Camici G, Manao G, Caselli A
J Neurochem. 2009
PubMed ID: 19457127
Glycosylation modification of human prion protein provokes apoptosis in HeLa cells in vitro.
Yang Y, Chen L, Pan HZ, Kou Y, Xu CM
BMB Rep. 2009
PubMed ID: 19558790
Morphology and secondary structure of stable beta-oligomers formed by amyloid peptide PrP(106-126).
Walsh P, Yau J, Simonetti K, Sharpe S
Biochemistry. 2009
PubMed ID: 19476383
Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration.
Chakrabarti O, Hegde RS
Cell. 2009
PubMed ID: 19524515
Early dysfunction of central 5-HT system in a murine model of bovine spongiform encephalopathy.
Vidal C, Herzog C, Haeberle AM, Bombarde C, Miquel MC, Carimalo J, Launay JM, Mouillet-Richard S, Lasmézas C, Dormont D, Kellermann O, Bailly Y
Neuroscience. 2009
PubMed ID: 19285121
Hydrogen/deuterium exchange mass spectrometry identifies two highly protected regions in recombinant full-length prion protein amyloid fibrils.
Nazabal A, Hornemann S, Aguzzi A, Zenobi R
J Mass Spectrom. 2009
PubMed ID: 19283723
The effects of prion protein expression on metal metabolism.
Kralovicova S, Fontaine SN, Alderton A, Alderman J, Ragnarsdottir KV, Collins SJ, Brown DR
Mol Cell Neurosci. 2009
PubMed ID: 19233277
A role of cellular prion protein in programming T-cell cytokine responses in disease.
Ingram RJ, Isaacs JD, Kaur G, Lowther DE, Reynolds CJ, Boyton RJ, Collinge J, Jackson GS, Altmann DM
FASEB J. 2009
PubMed ID: 19204074
Perturbation of T-cell development by insertional mutation of a PrP transgene.
Zabel M, Greenwood C, Thackray AM, Pulford B, Rens W, Bujdoso R
Immunology. 2009
PubMed ID: 19143847
Neuroglobin and prion cellular localization: investigation of a potential interaction.
Lechauve C, Rezaei H, Celier C, Kiger L, Corral-Debrinski M, Noinville S, Chauvierre C, Hamdane D, Pato C, Marden MC
J Mol Biol. 2009
PubMed ID: 19327369
UV-light-induced conversion and aggregation of prion proteins.
Redecke L, Binder S, Elmallah MI, Broadbent R, Tilkorn C, Schulz B, May P, Goos A, Eich A, Rübhausen M, Betzel C
Free Radic Biol Med. 2009
PubMed ID: 19249347
Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein.
Wolschner C, Giese A, Kretzschmar HA, Huber R, Moroder L, Budisa N
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19416900
[Polymorphism of the prion protein PRNP gene and risk of multiple sclerosis development in ethnic Russians from Bashkortostan]
Chubukova OV, Mustafina OE, Chemeris AV, Tuktarova IA, Bakhtiiarova KZ, Magzhanov RV, Nikonorov IuM
Genetika. 2009
PubMed ID: 19534429
Anti-PrP Mab 6D11 suppresses PrP(Sc) replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo.
Sadowski MJ, Pankiewicz J, Prelli F, Scholtzova H, Spinner DS, Kascsak RB, Kascsak RJ, Wisniewski T
Neurobiol Dis. 2009
PubMed ID: 19385058
Enhanced prion protein stability coupled to DNA recognition and milieu acidification.
Marques AF, Cordeiro Y, Silva JL, Lima LM
Biophys Chem. 2009
PubMed ID: 19286300
Folding kinetics of the human prion protein probed by temperature jump.
Hart T, Hosszu LL, Trevitt CR, Jackson GS, Waltho JP, Collinge J, Clarke AR
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19321423
The cellular prion protein and its role in Alzheimer disease.
Velayos JL, Irujo A, Cuadrado-Tejedor M, Paternain B, Moleres FJ, Ferrer V
Prion. 2009
PubMed ID: 19556894
Early onset prion disease from octarepeat expansion correlates with copper binding properties.
Stevens DJ, Walter ED, Rodríguez A, Draper D, Davies P, Brown DR, Millhauser GL
PLoS Pathog. 2009
PubMed ID: 19381258
Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
Wollscheid B, Bausch-Fluck D, Henderson C, O'Brien R, Bibel M, Schiess R, Aebersold R, Watts JD
Nat Biotechnol. 2009
PubMed ID: 19349973
Characterization of cell-surface prion protein relative to its recombinant analogue: insights from molecular dynamics simulations of diglycosylated, membrane-bound human prion protein.
DeMarco ML, Daggett V
J Neurochem. 2009
PubMed ID: 19226372
Identification of adjacent binding sites for the YY1 and E4BP4 transcription factors in the ovine PrP (Prion) gene promoter.
Burgess ST, Shen C, Ferguson LA, O'Neill GT, Docherty K, Hunter N, Goldmann W
J Biol Chem. 2009
PubMed ID: 19129193
Core structure of amyloid fibrils formed by residues 106-126 of the human prion protein.
Walsh P, Simonetti K, Sharpe S
Structure. 2009
PubMed ID: 19278656
Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein.
Wille H, Shanmugam M, Murugesu M, Ollesch J, Stubbs G, Long JR, Safar JG, Prusiner SB
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19223590
Earlier Onset of Alzheimer's Disease: Risk Polymorphisms Within PRNP, PRND, CYP46, and APOE Genes.
Golanska E, Hulas-Bigoszewska K, Sieruta M, Zawlik I, Witusik M, Gresner SM, Sobow T, Styczynska M, Peplonska B, Barcikowska M, Liberski PP, Corder EH
J Alzheimers Dis. 2009
PubMed ID: 19363267
Prion mutation D178N with highly variable disease onset and phenotype.
Synofzik M, Bauer P, Schöls L
J Neurol Neurosurg Psychiatry. 2009
PubMed ID: 19228673
Absence of spontaneous disease and comparative prion susceptibility of transgenic mice expressing mutant human prion proteins.
Asante EA, Gowland I, Grimshaw A, Linehan JM, Smidak M, Houghton R, Osiguwa O, Tomlinson A, Joiner S, Brandner S, Wadsworth JD, Collinge J
J Gen Virol. 2009
PubMed ID: 19218199
Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936.
Houlihan LM, Harris SE, Luciano M, Gow AJ, Starr JM, Visscher PM, Deary IJ
Genes Brain Behav. 2009
PubMed ID: 19077115
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.
Laurén J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM
Nature. 2009
PubMed ID: 19242475
Crystal structure of human prion protein bound to a therapeutic antibody.
Antonyuk SV, Trevitt CR, Strange RW, Jackson GS, Sangar D, Batchelor M, Cooper S, Fraser C, Jones S, Georgiou T, Khalili-Shirazi A, Clarke AR, Hasnain SS, Collinge J
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19204296
Deletion of the amino-terminal domain of the prion protein does not impair prion protein-dependent neuronal differentiation and neuritogenesis.
Barenco MG, Valori CF, Roncoroni C, Loewer J, Montrasio F, Rossi D
J Neurosci Res. 2009
PubMed ID: 18831069
ATM-mediated transcriptional elevation of prion in response to copper-induced oxidative stress.
Qin K, Zhao L, Ash RD, McDonough WF, Zhao RY
J Biol Chem. 2009
PubMed ID: 19064990
Human prion protein (PrP) 219K is converted to PrPSc but shows heterozygous inhibition in variant Creutzfeldt-Jakob disease infection.
Hizume M, Kobayashi A, Teruya K, Ohashi H, Ironside JW, Mohri S, Kitamoto T
J Biol Chem. 2009
PubMed ID: 19074151
Genetic polymorphism at codon 129 of the prion protein gene is not associated with multiple sclerosis.
Stüve O, Korth C, Gabatto P, Cameron EM, Hu W, Eagar TN, Monson NL, Frohman EM, Racke MK, Zabetian CP, Oksenberg JR
Arch Neurol. 2009
PubMed ID: 19204171
Helix 3 is necessary and sufficient for prion protein's anti-Bax function.
Laroche-Pierre S, Jodoin J, LeBlanc AC
J Neurochem. 2009
PubMed ID: 19196429
Dynamics of a truncated prion protein, PrP(113-231), from (15)N NMR relaxation: order parameters calculated and slow conformational fluctuations localized to a distinct region.
O'Sullivan DB, Jones CE, Abdelraheim SR, Brazier MW, Toms H, Brown DR, Viles JH
Protein Sci. 2009
PubMed ID: 19173221
Can copper binding to the prion protein generate a misfolded form of the protein?
Pushie MJ, Rauk A, Jirik FR, Vogel HJ
Biometals. 2009
PubMed ID: 19140013
The role of P-glycoprotein/cellular prion protein interaction in multidrug-resistant breast cancer cells treated with paclitaxel.
Li QQ, Cao XX, Xu JD, Chen Q, Wang WJ, Tang F, Chen ZQ, Liu XP, Xu ZD
Cell Mol Life Sci. 2009
PubMed ID: 19099191
alpha-cleavage of the prion protein occurs in a late compartment of the secretory pathway and is independent of lipid rafts.
Walmsley AR, Watt NT, Taylor DR, Perera WS, Hooper NM
Mol Cell Neurosci. 2009
PubMed ID: 19056496
Protein microarray analysis identifies human cellular prion protein interactors.
Satoh J, Obayashi S, Misawa T, Sumiyoshi K, Oosumi K, Tabunoki H
Neuropathol Appl Neurobiol. 2009
PubMed ID: 18482256
Biosynthesis of prion protein nucleocytoplasmic isoforms by alternative initiation of translation.
Juanes ME, Elvira G, García-Grande A, Calero M, Gasset M
J Biol Chem. 2009
PubMed ID: 19059915
Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB
Eur J Hum Genet. 2009
PubMed ID: 19156168
Regulation of prion gene expression by transcription factors SP1 and metal transcription factor-1.
Bellingham SA, Coleman LA, Masters CL, Camakaris J, Hill AF
J Biol Chem. 2009
PubMed ID: 18990686
De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis.
Sigurdson CJ, Nilsson KP, Hornemann S, Heikenwalder M, Manco G, Schwarz P, Ott D, Rülicke T, Liberski PP, Julius C, Falsig J, Stitz L, Wüthrich K, Aguzzi A
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19073920
PRNP variation in UK sporadic and variant Creutzfeldt Jakob disease highlights genetic risk factors and a novel non-synonymous polymorphism.
Bishop MT, Pennington C, Heath CA, Will RG, Knight RS
BMC Med Genet. 2009
PubMed ID: 20035629
Unfolded-state structure and dynamics influence the fibril formation of human prion protein.
Gerum C, Silvers R, Wirmer-Bartoschek J, Schwalbe H
Angew Chem Int Ed Engl. 2009
PubMed ID: 19882604
Regulation of GABA(A) and glutamate receptor expression, synaptic facilitation and long-term potentiation in the hippocampus of prion mutant mice.
Rangel A, Madroñal N, Gruart i Massó A, Gavín R, Llorens F, Sumoy L, Torres JM, Delgado-García JM, Del Río JA
PLoS One. 2009
PubMed ID: 19855845
Manganese enhances prion protein survival in model soils and increases prion infectivity to cells.
Davies P, Brown DR
PLoS One. 2009
PubMed ID: 19844576
Transmissibility of atypical scrapie in ovine transgenic mice: major effects of host prion protein expression and donor prion genotype.
Arsac JN, Bétemps D, Morignat E, Féraudet C, Bencsik A, Aubert D, Grassi J, Baron T
PLoS One. 2009
PubMed ID: 19806224
Functionally relevant domains of the prion protein identified in vivo.
Baumann F, Pahnke J, Radovanovic I, Rülicke T, Bremer J, Tolnay M, Aguzzi A
PLoS One. 2009
PubMed ID: 19738901
Mutations at codons 178, 200-129, and 232 contributed to the inherited prion diseases in Korean patients.
Choi BY, Kim SY, Seo SY, An SS, Kim S, Park SE, Lee SH, Choi YJ, Kim SJ, Kim CK, Park JS, Ju YR
BMC Infect Dis. 2009
PubMed ID: 19698114
Efficient knockdown of human prnp mRNA expression levels using hybrid hammerhead ribozymes.
Stobart MJ, Simon SL, Plews M, Lamoureux L, Knox JD
J Toxicol Environ Health A. 2009
PubMed ID: 19697238
Cerebral amyloid angiopathy: a common cause of cerebral hemorrhage.
Pezzini A, Del Zotto E, Volonghi I, Giossi A, Costa P, Padovani A
Curr Med Chem. 2009
PubMed ID: 19601795
Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport.
Singh A, Kong Q, Luo X, Petersen RB, Meyerson H, Singh N
PLoS One. 2009
PubMed ID: 19568430
Total prion protein levels in the cerebrospinal fluid are reduced in patients with various neurological disorders.
Meyne F, Gloeckner SF, Ciesielczyk B, Heinemann U, Krasnianski A, Meissner B, Zerr I
J Alzheimers Dis. 2009
PubMed ID: 19542614
Lipid rafts and clathrin cooperate in the internalization of PrP in epithelial FRT cells.
Sarnataro D, Caputo A, Casanova P, Puri C, Paladino S, Tivodar SS, Campana V, Tacchetti C, Zurzolo C
PLoS One. 2009
PubMed ID: 19503793
Prion protein expression and processing in human mononuclear cells: the impact of the codon 129 prion gene polymorphism.
Segarra C, Lehmann S, Coste J
PLoS One. 2009
PubMed ID: 19495414
Activation of p53-regulated pro-apoptotic signaling pathways in PrP-mediated myopathy.
Liang J, Parchaliuk D, Medina S, Sorensen G, Landry L, Huang S, Wang M, Kong Q, Booth SA
BMC Genomics. 2009
PubMed ID: 19400950
Lack of association between PRNP 1368 polymorphism and Alzheimer's disease or vascular dementia.
Jeong BH, Lee KH, Lee YJ, Kim YJ, Choi EK, Kim YH, Cho YS, Carp RI, Kim YS
BMC Med Genet. 2009
PubMed ID: 19351416
Prion protein modulates cellular iron uptake: a novel function with implications for prion disease pathogenesis.
Singh A, Mohan ML, Isaac AO, Luo X, Petrak J, Vyoral D, Singh N
PLoS One. 2009
PubMed ID: 19212444
Methionine sulfoxides on prion protein Helix-3 switch on the alpha-fold destabilization required for conversion.
Colombo G, Meli M, Morra G, Gabizon R, Gasset M
PLoS One. 2009
PubMed ID: 19172188
Olfactory behavior and physiology are disrupted in prion protein knockout mice.
Le Pichon CE, Valley MT, Polymenidou M, Chesler AT, Sagdullaev BT, Aguzzi A, Firestein S
Nat Neurosci. 2009
PubMed ID: 19098904
Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study.
Mead S, Poulter M, Uphill J, Beck J, Whitfield J, Webb TE, Campbell T, Adamson G, Deriziotis P, Tabrizi SJ, Hummerich H, Verzilli C, Alpers MP, Whittaker JC, Collinge J
Lancet Neurol. 2009
PubMed ID: 19081515
The role of stress and anxiety in the onset of familial Creutzfeldt-Jakob Disease (CJD): review.
Gigi A
Stress. 2009
PubMed ID: 19051123
A deleted prion protein that is neurotoxic in vivo is localized normally in cultured cells.
Christensen HM, Harris DA
J Neurochem. 2009
PubMed ID: 19046329
A thermodynamic approach to the conformational preferences of the 180-195 segment derived from the human prion protein alpha2-helix.
Ronga L, Palladino P, Ragone R, Benedetti E, Rossi F
J Pept Sci. 2009
PubMed ID: 19035579
Immunolocalisation of PrPSc in scrapie-infected N2a mouse neuroblastoma cells by light and electron microscopy.
Veith NM, Plattner H, Stuermer CA, Schulz-Schaeffer WJ, Bürkle A
Eur J Cell Biol. 2009
PubMed ID: 18834644
Critical region for amyloid fibril formation of mouse prion protein: unusual amyloidogenic properties of the helix 2 peptide.
Yamaguchi K, Matsumoto T, Kuwata K
Biochemistry. 2008
PubMed ID: 19053276
Atypical presentation of Creutzfeldt-Jakob disease: the first Italian case associated with E196K mutation in the PRNP gene.
Clerici F, Elia A, Girotti F, Contri P, Mariani C, Tagliavini F, Di Fede G
J Neurol Sci. 2008
PubMed ID: 18706660
Prion protein amyloid formation under native-like conditions involves refolding of the C-terminal alpha-helical domain.
Cobb NJ, Apetri AC, Surewicz WK
J Biol Chem. 2008
PubMed ID: 18930924
Cellular prion protein modulates defensive attention and innate fear-induced behaviour evoked in transgenic mice submitted to an agonistic encounter with the tropical coral snake Oxyrhopus guibei.
Lobão-Soares B, Walz R, Prediger RD, Freitas RL, Calvo F, Bianchin MM, Leite JP, Landemberger MC, Coimbra NC
Behav Brain Res. 2008
PubMed ID: 18590772
Identifying key components of the PrPC-PrPSc replicative interface.
Abalos GC, Cruite JT, Bellon A, Hemmers S, Akagi J, Mastrianni JA, Williamson RA, Solforosi L
J Biol Chem. 2008
PubMed ID: 18826953
Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities.
Chiesa R, Piccardo P, Biasini E, Ghetti B, Harris DA
J Neurosci. 2008
PubMed ID: 19052217
Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas.
Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson CJ, Aguzzi A
Immunity. 2008
PubMed ID: 19100703
Atypical frontotemporal dementia as a new clinical phenotype of Gerstmann-Straussler-Scheinker disease with the PrP-P102L mutation. Description of a previously unreported Italian family.
Giovagnoli AR, Di Fede G, Aresi A, Reati F, Rossi G, Tagliavini F
Neurol Sci. 2008
PubMed ID: 19030774
A novel insertional mutation in the prion protein gene: clinical and bio-molecular findings.
Mauro C, Giaccone G, Piscosquito G, Lavorgna A, Nigro M, Di Fede G, Leonardi A, Coppola C, Formisano S, Tagliavini F, Cotrufo R, Puoti G
J Neurol Neurosurg Psychiatry. 2008
PubMed ID: 19010951
Opposing roles of prion protein in oxidative stress- and ER stress-induced apoptotic signaling.
Anantharam V, Kanthasamy A, Choi CJ, Martin DP, Latchoumycandane C, Richt JA, Kanthasamy AG
Free Radic Biol Med. 2008
PubMed ID: 18835352
Dynamics and local ordering of spin-labeled prion protein: an ESR simulation study of a highly PH-sensitive site.
Chiang YW, Otoshima Y, Watanabe Y, Inanami O, Shimoyama Y
J Biomol Struct Dyn. 2008
PubMed ID: 18808201
Species-specific anti-apoptotic activity of cellular prion protein in a mouse PrP-deficient neuronal cell line transfected with mouse, hamster, and bovine Prnp.
Wu G, Nakajima K, Takeyama N, Yukawa M, Taniuchi Y, Sakudo A, Onodera T
Neurosci Lett. 2008
PubMed ID: 18809465
Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model.
Dossena S, Imeri L, Mangieri M, Garofoli A, Ferrari L, Senatore A, Restelli E, Balducci C, Fiordaliso F, Salio M, Bianchi S, Fioriti L, Morbin M, Pincherle A, Marcon G, Villani F, Carli M, Tagliavini F, Forloni G, Chiesa R
Neuron. 2008
PubMed ID: 19038218
Mild cognitive deficits associated to neocortical microgyria in mice with genetic deletion of cellular prion protein.
Xikota JC, Rial D, Ruthes D, Pereira R, Figueiredo CP, Prediger RD, Walz R
Brain Res. 2008
PubMed ID: 18840415
Resistance of bovine spongiform encephalopathy (BSE) prions to inactivation.
Giles K, Glidden DV, Beckwith R, Seoanes R, Peretz D, DeArmond SJ, Prusiner SB
PLoS Pathog. 2008
PubMed ID: 19008948
Atlas of gene expression in the developing kidney at microanatomic resolution.
Brunskill EW, Aronow BJ, Georgas K, Rumballe B, Valerius MT, Aronow J, Kaimal V, Jegga AG, Grimmond S, McMahon AP, Patterson LT, Little MH, Potter SS
Dev Cell. 2008
PubMed ID: 19000842
Ligand binding promotes prion protein aggregation--role of the octapeptide repeats.
Yu S, Yin S, Pham N, Wong P, Kang SC, Petersen RB, Li C, Sy MS
FEBS J. 2008
PubMed ID: 18959744
Increased PrPC expression correlates with endoglin (CD105) positive microvessels in advanced carotid lesions.
Krupinski J, Turu MM, Luque A, Badimon L, Slevin M
Acta Neuropathol. 2008
PubMed ID: 18810471
Human cellular prion protein interacts directly with clusterin protein.
Xu F, Karnaukhova E, Vostal JG
Biochim Biophys Acta. 2008
PubMed ID: 18786636
Isoform-specific contribution of protein kinase C to prion processing.
Alfa Cissé M, Louis K, Braun U, Mari B, Leitges M, Slack BE, Fisher A, Auberger P, Checler F, Vincent B
Mol Cell Neurosci. 2008
PubMed ID: 18722532
The cellular prion protein is preferentially expressed by CD4+ CD25+ Foxp3+ regulatory T cells.
Isaacs JD, Garden OA, Kaur G, Collinge J, Jackson GS, Altmann DM
Immunology. 2008
PubMed ID: 18462346
Chemically induced accumulation of GAGs delays PrP(Sc) clearance but prolongs prion disease incubation time.
Mayer-Sonnenfeld T, Avrahami D, Friedman-Levi Y, Gabizon R
Cell Mol Neurobiol. 2008
PubMed ID: 18350378
A novel PRNP-P105S mutation associated with atypical prion disease and a rare PrPSc conformation.
Tunnell E, Wollman R, Mallik S, Cortes CJ, Dearmond SJ, Mastrianni JA
Neurology. 2008
PubMed ID: 18955686
Evidence for stepwise formation of amyloid fibrils by the mouse prion protein.
Jain S, Udgaonkar JB
J Mol Biol. 2008
PubMed ID: 18687339
Hypothalamic-pituitary-adrenal axis disregulation in PrPC-null mice.
Sanchez-Alavez M, Criado JR, Klein I, Moroncini G, Conti B
Neuroreport. 2008
PubMed ID: 18797300
Unaltered SNARE complex formation in an in vivo model of prion disease.
Asuni AA, Cunningham C, Vigneswaran P, Perry VH, O'Connor V
Brain Res. 2008
PubMed ID: 18706894
Assessment of Alzheimer's disease case-control associations using family-based methods.
Schjeide BM, McQueen MB, Mullin K, Divito J, Hogan MF, Parkinson M, Hooli B, Lange C, Blacker D, Tanzi RE, Bertram L
Neurogenetics. 2008
PubMed ID: 18830724
Absence of the cellular prion protein exacerbates and prolongs neuroinflammation in experimental autoimmune encephalomyelitis.
Tsutsui S, Hahn JN, Johnson TA, Ali Z, Jirik FR
Am J Pathol. 2008
PubMed ID: 18815152
Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP.
Rambold AS, Miesbauer M, Olschewski D, Seidel R, Riemer C, Smale L, Brumm L, Levy M, Gazit E, Oesterhelt D, Baier M, Becker CF, Engelhard M, Winklhofer KF, Tatzelt J
J Neurochem. 2008
PubMed ID: 18691383
The involvement of cellular prion protein in the autophagy pathway in neuronal cells.
Oh JM, Shin HY, Park SJ, Kim BH, Choi JK, Choi EK, Carp RI, Kim YS
Mol Cell Neurosci. 2008
PubMed ID: 18674620
Hippocampal bursts caused by changes in NMDA receptor-dependent excitation in a mouse model of variant CJD.
Ratté S, Prescott SA, Collinge J, Jefferys JG
Neurobiol Dis. 2008
PubMed ID: 18638557
Structural characterization of a neurotoxic threonine-rich peptide corresponding to the human prion protein alpha 2-helical 180-195 segment, and comparison with full-length alpha 2-helix-derived peptides.
Ronga L, Palladino P, Saviano G, Tancredi T, Benedetti E, Ragone R, Rossi F
J Pept Sci. 2008
PubMed ID: 18563793
Conformational plasticity of the Gerstmann-Sträussler-Scheinker disease peptide as indicated by its multiple aggregation pathways.
Natalello A, Prokorov VV, Tagliavini F, Morbin M, Forloni G, Beeg M, Manzoni C, Colombo L, Gobbi M, Salmona M, Doglia SM
J Mol Biol. 2008
PubMed ID: 18619462
Nanomechanical properties of human prion protein amyloid as probed by force spectroscopy.
Ganchev DN, Cobb NJ, Surewicz K, Surewicz WK
Biophys J. 2008
PubMed ID: 18539633
Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration.
Rane NS, Kang SW, Chakrabarti O, Feigenbaum L, Hegde RS
Dev Cell. 2008
PubMed ID: 18804434
Dominant-negative effects of the N-terminal half of prion protein on neurotoxicity of prion protein-like protein/doppel in mice.
Yoshikawa D, Yamaguchi N, Ishibashi D, Yamanaka H, Okimura N, Yamaguchi Y, Mori T, Miyata H, Shigematsu K, Katamine S, Sakaguchi S
J Biol Chem. 2008
PubMed ID: 18562311
Methionine sulfoxides on PrPSc: a prion-specific covalent signature.
Canello T, Engelstein R, Moshel O, Xanthopoulos K, Juanes ME, Langeveld J, Sklaviadis T, Gasset M, Gabizon R
Biochemistry. 2008
PubMed ID: 18680312
Inter-oligomer interactions of the human prion protein are modulated by the polymorphism at codon 129.
Gerber R, Voitchovsky K, Mitchel C, Tahiri-Alaoui A, Ryan JF, Hore PJ, James W
J Mol Biol. 2008
PubMed ID: 18597782
M129V polymorphism in the prion protein gene is not associated with mesial temporal lobe epilepsy in a Han Chinese population.
Wang X, Sun W, Zhu X, Wu X, Li L, Zhu S, Du T, Liu Y, Niu N, Wang Y, Liu Y
Eur J Neurol. 2008
PubMed ID: 18549399
PRNP 1368 polymorphism is not associated with sporadic Creutzfeldt-Jakob disease in the Korean population.
Jeong BH, Lee KH, Lee YJ, Kim YH, Cho YS, Carp RI, Kim YS
Eur J Neurol. 2008
PubMed ID: 18549395
Retrotranslocation of prion proteins from the endoplasmic reticulum by preventing GPI signal transamidation.
Ashok A, Hegde RS
Mol Biol Cell. 2008
PubMed ID: 18508914
Evidence for an association of prion protein and sphingolipid-mediated signaling.
Schmalzbauer R, Eigenbrod S, Winoto-Morbach S, Xiang W, Schütze S, Bertsch U, Kretzschmar HA
J Neurochem. 2008
PubMed ID: 18498440
Differences of apparent diffusion coefficient values in patients with Creutzfeldt-Jakob disease according to the codon 129 genotype.
Galanaud D, Dormont D, Haïk S, Chiras J, Brandel JP, Ranjeva JP
AJNR Am J Neuroradiol. 2008
PubMed ID: 18372408
Stress-protective signalling of prion protein is corrupted by scrapie prions.
Rambold AS, Müller V, Ron U, Ben-Tal N, Winklhofer KF, Tatzelt J
EMBO J. 2008
PubMed ID: 18566584
Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease.
White MD, Farmer M, Mirabile I, Brandner S, Collinge J, Mallucci GR
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18632556
Altered neuron excitability and synaptic plasticity in the cerebellar granular layer of juvenile prion protein knock-out mice with impaired motor control.
Prestori F, Rossi P, Bearzatto B, Lainé J, Necchi D, Diwakar S, Schiffmann SN, Axelrad H, D'Angelo E
J Neurosci. 2008
PubMed ID: 18614678
The brain proteome profile is highly conserved between Prnp-/- and Prnp+/+ mice.
Crecelius AC, Helmstetter D, Strangmann J, Mitteregger G, Fröhlich T, Arnold GJ, Kretzschmar HA
Neuroreport. 2008
PubMed ID: 18580573
Reversible monomer-oligomer transition in human prion protein.
Sasaki K, Gaikwad J, Hashiguchi S, Kubota T, Sugimura K, Kremer W, Kalbitzer HR, Akasaka K
Prion. 2008
PubMed ID: 19158507
GFP-tagged mutant prion protein forms intra-axonal aggregates in transgenic mice.
Medrano AZ, Barmada SJ, Biasini E, Harris DA
Neurobiol Dis. 2008
PubMed ID: 18514536
The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding.
Heiseke A, Schöbel S, Lichtenthaler SF, Vorberg I, Groschup MH, Kretzschmar H, Schätzl HM, Nunziante M
Traffic. 2008
PubMed ID: 18419754
Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1.
Caetano FA, Lopes MH, Hajj GN, Machado CF, Pinto Arantes C, Magalhães AC, Vieira Mde P, Américo TA, Massensini AR, Priola SA, Vorberg I, Gomez MV, Linden R, Prado VF, Martins VR, Prado MA
J Neurosci. 2008
PubMed ID: 18579743
Expansion of the octarepeat domain alters the misfolding pathway but not the folding pathway of the prion protein.
Leliveld SR, Stitz L, Korth C
Biochemistry. 2008
PubMed ID: 18473442
Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8.
Kranich J, Krautler NJ, Heinen E, Polymenidou M, Bridel C, Schildknecht A, Huber C, Kosco-Vilbois MH, Zinkernagel R, Miele G, Aguzzi A
J Exp Med. 2008
PubMed ID: 18490487
Hypoxia induces expression of a GPI-anchorless splice variant of the prion protein.
Kikuchi Y, Kakeya T, Nakajima O, Sakai A, Ikeda K, Yamaguchi N, Yamazaki T, Tanamoto K, Matsuda H, Sawada J, Takatori K
FEBS J. 2008
PubMed ID: 18445040
Native, amyloid fibrils and beta-oligomers of the C-terminal domain of human prion protein display differential activation of complement and bind C1q, factor H and C4b-binding protein directly.
Sjöberg AP, Nyström S, Hammarström P, Blom AM
Mol Immunol. 2008
PubMed ID: 18406463
Globular and pre-fibrillar prion aggregates are toxic to neuronal cells and perturb their electrophysiology.
Sanghera N, Wall M, Vénien-Bryan C, Pinheiro TJ
Biochim Biophys Acta. 2008
PubMed ID: 18374666
Evidence for prion protein expression in enteroglial cells of the myenteric plexus of mouse intestine.
Albanese V, Lawson VA, Hill AF, Cappai R, Di Guardo G, Staikopoulos V, Thacker M, Furness JB, Chiocchetti R
Auton Neurosci. 2008
PubMed ID: 18358791
The deletion of amino acids 114-121 in the TM1 domain of mouse prion protein stabilizes its conformation but does not affect the overall structure.
Thaa B, Zahn R, Matthey U, Kroneck PM, Bürkle A, Fritz G
Biochim Biophys Acta. 2008
PubMed ID: 18088603
Expression and localization of the prion protein PrP(C) in the olfactory system of the mouse.
Le Pichon CE, Firestein S
J Comp Neurol. 2008
PubMed ID: 18338400
Thr but Asn of the N-glycosylation sites of PrP is indispensable for its misfolding.
Ikeda S, Kobayashi A, Kitamoto T
Biochem Biophys Res Commun. 2008
PubMed ID: 18343219
Manganese binding to the prion protein.
Brazier MW, Davies P, Player E, Marken F, Viles JH, Brown DR
J Biol Chem. 2008
PubMed ID: 18332141
Prion protein attenuates excitotoxicity by inhibiting NMDA receptors.
Khosravani H, Zhang Y, Tsutsui S, Hameed S, Altier C, Hamid J, Chen L, Villemaire M, Ali Z, Jirik FR, Zamponi GW
J Cell Biol. 2008
PubMed ID: 18443219
Novel PRNP mutation in a patient with a slow progressive dementia syndrome.
Heinemann U, Krasnianski A, Meissner B, Grasbon-Frodl EM, Kretzschmar HA, Zerr I
Med Sci Monit. 2008
PubMed ID: 18443555
Fibrillar prion peptide PrP(106-126) treatment induces Dab1 phosphorylation and impairs APP processing and A beta production in cortical neurons.
Gavín R, Ureña J, Rangel A, Pastrana MA, Requena JR, Soriano E, Aguzzi A, Del Río JA
Neurobiol Dis. 2008
PubMed ID: 18374587
Molecular evidence of founder effects of fatal familial insomnia through SNP haplotypes around the D178N mutation.
Rodríguez-Martínez AB, Alfonso-Sánchez MA, Peña JA, Sánchez-Valle R, Zerr I, Capellari S, Calero M, Zarranz JJ, de Pancorbo MM
Neurogenetics. 2008
PubMed ID: 18347820
Subcellular localization of prion proteins and the 37 kDa/67 kDa laminin receptor fused to fluorescent proteins.
Nikles D, Vana K, Gauczynski S, Knetsch H, Ludewigs H, Weiss S
Biochim Biophys Acta. 2008
PubMed ID: 18339329
Expression of cellular prion protein (PrP(c)) in schizophrenia, bipolar disorder, and depression.
Weis S, Haybaeck J, Dulay JR, Llenos IC
J Neural Transm. 2008
PubMed ID: 18188498
Reduced erythroid cell and erythropoietin production in response to acute anemia in prion protein-deficient (Prnp-/-) mice.
Zivny JH, Gelderman MP, Xu F, Piper J, Holada K, Simak J, Vostal JG
Blood Cells Mol Dis. 2008
PubMed ID: 17964827
Molecular conformation and dynamics of the Y145Stop variant of human prion protein in amyloid fibrils.
Helmus JJ, Surewicz K, Nadaud PS, Surewicz WK, Jaroniec CP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18436646
PRNP mutations in a series of apparently sporadic neurodegenerative dementias in China.
Zheng L, Longfei J, Jing Y, Xinqing Z, Haiqing S, Haiyan L, Fen W, Xiumin D, Jianping J
Am J Med Genet B Neuropsychiatr Genet. 2008
PubMed ID: 18425766
Normal cellular prion protein with a methionine at position 129 has a more exposed helix 1 and is more prone to aggregate.
Pham N, Yin S, Yu S, Wong P, Kang SC, Li C, Sy MS
Biochem Biophys Res Commun. 2008
PubMed ID: 18275852
Host PrP glycosylation: a major factor determining the outcome of prion infection.
Tuzi NL, Cancellotti E, Baybutt H, Blackford L, Bradford B, Plinston C, Coghill A, Hart P, Piccardo P, Barron RM, Manson JC
PLoS Biol. 2008
PubMed ID: 18416605
Alterations in Ca2+-buffering in prion-null mice: association with reduced afterhyperpolarizations in CA1 hippocampal neurons.
Powell AD, Toescu EC, Collinge J, Jefferys JG
J Neurosci. 2008
PubMed ID: 18400886
Population distribution of the methionine allele at the PRNP codon 129 polymorphism in Europe and the Middle East.
Mercier G, Diéterlen F, Lucotte G
Hum Biol. 2008
PubMed ID: 18720902
In vivo detection of thalamic gliosis: a pathoradiologic demonstration in familial fatal insomnia.
Haïk S, Galanaud D, Linguraru MG, Peoc'h K, Privat N, Faucheux BA, Ayache N, Hauw JJ, Dormont D, Brandel JP
Arch Neurol. 2008
PubMed ID: 18413481
Pathogenic mutations in the glycosylphosphatidylinositol signal peptide of PrP modulate its topology in neuroblastoma cells.
Gu Y, Singh A, Bose S, Singh N
Mol Cell Neurosci. 2008
PubMed ID: 18325785
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Cellular prion protein electron microscopy: attempts/limits and clues to a synaptic trait. Implications in neurodegeneration process.
Fournier JG
Cell Tissue Res. 2008
PubMed ID: 18236081
The normal distribution of PRNP codon 129 polymorphism in the Moroccan population (Arabs and Casablanca residents).
Nadifi S, Slassi I, Hachimi KM, Gazzaz B, Bellayou H, Raddaoui K, Laplanche JL
Pathol Biol (Paris). 2008
PubMed ID: 18191917
Observing fibrillar assemblies on scrapie-infected cells.
Wegmann S, Miesbauer M, Winklhofer KF, Tatzelt J, Muller DJ
Pflugers Arch. 2008
PubMed ID: 18175144
Complex I specific increase in superoxide formation and respiration rate by PrP-null mouse brain mitochondria.
Paterson AW, Curtis JC, Macleod NK
J Neurochem. 2008
PubMed ID: 17999717
Kuru prions and sporadic Creutzfeldt-Jakob disease prions have equivalent transmission properties in transgenic and wild-type mice.
Wadsworth JD, Joiner S, Linehan JM, Desbruslais M, Fox K, Cooper S, Cronier S, Asante EA, Mead S, Brandner S, Hill AF, Collinge J
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18316717
POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?
Antonacopoulou AG, Grivas PD, Skarlas L, Kalofonos M, Scopa CD, Kalofonos HP
Anticancer Res. 2008
PubMed ID: 18505059
Conformational pH dependence of intermediate states during oligomerization of the human prion protein.
Gerber R, Tahiri-Alaoui A, Hore PJ, James W
Protein Sci. 2008
PubMed ID: 18218718
Human tau protein forms complex with PrP and some GSS- and fCJD-related PrP mutants possess stronger binding activities with tau in vitro.
Wang XF, Dong CF, Zhang J, Wan YZ, Li F, Huang YX, Han L, Shan B, Gao C, Han J, Dong XP
Mol Cell Biochem. 2008
PubMed ID: 18038270
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Prion protein aggresomes are poly(A)+ ribonucleoprotein complexes that induce a PKR-mediated deficient cell stress response.
Goggin K, Beaudoin S, Grenier C, Brown AA, Roucou X
Biochim Biophys Acta. 2008
PubMed ID: 18023289
Conformational stability of PrP amyloid fibrils controls their smallest possible fragment size.
Sun Y, Makarava N, Lee CI, Laksanalamai P, Robb FT, Baskakov IV
J Mol Biol. 2008
PubMed ID: 18206163
Raman optical activity and circular dichroism reveal dramatic differences in the influence of divalent copper and manganese ions on prion protein folding.
Zhu F, Davies P, Thompsett AR, Kelly SM, Tranter GE, Hecht L, Isaacs NW, Brown DR, Barron LD
Biochemistry. 2008
PubMed ID: 18205409
A monoclonal antibody (1D12) defines novel distribution patterns of prion protein (PrP) as granules in nucleus.
Hosokawa T, Tsuchiya K, Sato I, Takeyama N, Ueda S, Tagawa Y, Kimura KM, Nakamura I, Wu G, Sakudo A, Casalone C, Mazza M, Caramelli M, Takahashi H, Sata T, Sugiura K, Baj A, Toniolo A, Onodera T
Biochem Biophys Res Commun. 2008
PubMed ID: 18068119
Copper binding sites in the C-terminal domain of mouse prion protein: A hybrid (QM/MM) molecular dynamics study.
Colombo MC, Vandevondele J, Van Doorslaer S, Laio A, Guidoni L, Rothlisberger U
Proteins. 2008
PubMed ID: 17876822
Cellular prion protein co-localizes with nAChR beta4 subunit in brain and gastrointestinal tract.
Petrakis S, Irinopoulou T, Panagiotidis CH, Engelstein R, Lindstrom J, Orr-Urtreger A, Gabizon R, Grigoriadis N, Sklaviadis T
Eur J Neurosci. 2008
PubMed ID: 18279314
Copper(II) ion binding to cellular prion protein.
Zidar J, Pirc ET, Hodoscek M, Bukovec P
J Chem Inf Model. 2008
PubMed ID: 18247504
PRNP M129V homozygosity in multiple system atrophy vs. Parkinson's disease.
Shibao C, Garland EM, Gamboa A, Vnencak-Jones CL, Van Woeltz M, Haines JL, Yu C, Biaggioni I
Clin Auton Res. 2008
PubMed ID: 18236005
Codon 129 polymorphism of prion protein gene in sporadic Alzheimer's disease.
Poleggi A, Bizzarro A, Acciarri A, Antuono P, Bagnoli S, Cellini E, Forno GD, Giannattasio C, Lauria A, Matera MG, Nacmias B, Puopolo M, Seripa D, Sorbi S, Wekstein DR, Pocchiari M, Masullo C
Eur J Neurol. 2008
PubMed ID: 18217885
GPI-anchorless human prion protein is secreted and glycosylated but lacks superoxide dismutase activity.
Sakudo A, Nakamura I, Tsuji S, Ikuta K
Int J Mol Med. 2008
PubMed ID: 18204788
Deconvoluting the Cu2+ binding modes of full-length prion protein.
Klewpatinond M, Davies P, Bowen S, Brown DR, Viles JH
J Biol Chem. 2008
PubMed ID: 18042548
PrPSc level and incubation time in a transgenic mouse model expressing Borna disease virus phosphoprotein after intracerebral prion infection.
Sakudo A, Onodera T, Ikuta K
Neurosci Lett. 2008
PubMed ID: 18155836
PrP N-terminal domain triggers PrP(Sc)-like aggregation of Dpl.
Erlich P, Cesbron JY, Lemaire-Vieille C, Curt A, Andrieu JP, Schoehn G, Jamin M, Gagnon J
Biochem Biophys Res Commun. 2008
PubMed ID: 17997980
Octapeptide repeat region of prion protein (PrP) is required at an early stage for production of abnormal prion protein in PrP-deficient neuronal cell line.
Sakudo A, Wu G, Onodera T, Ikuta K
Biochem Biophys Res Commun. 2008
PubMed ID: 17981146
Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H
BMC Genomics. 2008
PubMed ID: 18973680
Regulating factors of PrP glycosylation in Creutzfeldt-Jakob disease--implications for the dissemination and the diagnosis of human prion strains.
Levavasseur E, Laffont-Proust I, Morain E, Faucheux BA, Privat N, Peoc'h K, Sazdovitch V, Brandel JP, Hauw JJ, Haïk S
PLoS ONE. 2008
PubMed ID: 18665216
UV-light exposed prion protein fails to form amyloid fibrils.
Thakur AK, Rao ChM
PLoS ONE. 2008
PubMed ID: 18628989
Evidence for a pathogenic role of different mutations at codon 188 of PRNP.
Roeber S, Grasbon-Frodl EM, Windl O, Krebs B, Xiang W, Vollmert C, Illig T, Schröter A, Arzberger T, Weber P, Zerr I, Kretzschmar HA
PLoS ONE. 2008
PubMed ID: 18478114
Overexpression of cellular prion protein alters postischemic Erk1/2 phosphorylation but not Akt phosphorylation and protects against focal cerebral ischemia.
Weise J, Doeppner TR, Müller T, Wrede A, Schulz-Schaeffer W, Zerr I, Witte OW, Bähr M
Restor Neurol Neurosci. 2008
PubMed ID: 18431006
Prion protein M129V polymorphism affects retrieval-related brain activity.
Buchmann A, Mondadori CR, Hänggi J, Aerni A, Vrticka P, Luechinger R, Boesiger P, Hock C, Nitsch RM, de Quervain DJ, Papassotiropoulos A, Henke K
Neuropsychologia. 2008
PubMed ID: 18423780
Association between deposition of beta-amyloid and pathological prion protein in sporadic Creutzfeldt-Jakob disease.
Debatin L, Streffer J, Geissen M, Matschke J, Aguzzi A, Glatzel M
Neurodegener Dis. 2008
PubMed ID: 18349519
Survival in Alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon 4 allele.
Giannattasio C, Poleggi A, Puopolo M, Pocchiari M, Antuono P, Dal Forno G, Wekstein DR, Matera MG, Seripa D, Acciarri A, Bizzarro A, Lauria A, Masullo C
Dement Geriatr Cogn Disord. 2008
PubMed ID: 18332630
A versatile prion replication assay in organotypic brain slices.
Falsig J, Julius C, Margalith I, Schwarz P, Heppner FL, Aguzzi A
Nat Neurosci. 2008
PubMed ID: 18066056
The M129V polymorphism of codon 129 in the prion gene (PRNP) in the Danish population.
Dyrbye H, Broholm H, Dziegiel MH, Laursen H
Eur J Epidemiol. 2008
PubMed ID: 17987393
Relevance of the N-terminal NLS-like sequence of the prion protein for membrane perturbation effects.
Oglecka K, Lundberg P, Magzoub M, Göran Eriksson LE, Langel U, Gräslund A
Biochim Biophys Acta. 2008
PubMed ID: 17967411
The prion protein is a combined zinc and copper binding protein: Zn2+ alters the distribution of Cu2+ coordination modes.
Walter ED, Stevens DJ, Visconte MP, Millhauser GL
J Am Chem Soc. 2007
PubMed ID: 18034490
Normal prion protein trafficking in cultured human erythroblasts.
Griffiths RE, Heesom KJ, Anstee DJ
Blood. 2007
PubMed ID: 17827389
Hemin interactions and alterations of the subcellular localization of prion protein.
Lee KS, Raymond LD, Schoen B, Raymond GJ, Kett L, Moore RA, Johnson LM, Taubner L, Speare JO, Onwubiko HA, Baron GS, Caughey WS, Caughey B
J Biol Chem. 2007
PubMed ID: 17925394
High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrPSc in vivo.
Barron RM, Campbell SL, King D, Bellon A, Chapman KE, Williamson RA, Manson JC
J Biol Chem. 2007
PubMed ID: 17923484
Neuronal and astrocytic cells, obtained after differentiation of human neural GFAP-positive progenitors, present heterogeneous expression of PrPc.
Witusik M, Gresner SM, Hulas-Bigoszewska K, Krynska B, Azizi SA, Liberski PP, Brown P, Rieske P
Brain Res. 2007
PubMed ID: 17996224
Cellular prion protein expression in astrocytes modulates neuronal survival and differentiation.
Lima FR, Arantes CP, Muras AG, Nomizo R, Brentani RR, Martins VR
J Neurochem. 2007
PubMed ID: 17868300
Molecular architecture of human prion protein amyloid: a parallel, in-register beta-structure.
Cobb NJ, Sönnichsen FD, McHaourab H, Surewicz WK
Proc Natl Acad Sci U S A. 2007
PubMed ID: 18025469
Silencing of prion protein sensitizes breast adriamycin-resistant carcinoma cells to TRAIL-mediated cell death.
Meslin F, Hamaï A, Gao P, Jalil A, Cahuzac N, Chouaib S, Mehrpour M
Cancer Res. 2007
PubMed ID: 18006836
Prion protein regulates glutamate-dependent lactate transport of astrocytes.
Kleene R, Loers G, Langer J, Frobert Y, Buck F, Schachner M
J Neurosci. 2007
PubMed ID: 17989297
Two different clinical phenotypes of Creutzfeldt-Jakob disease with a M232R substitution.
Shiga Y, Satoh K, Kitamoto T, Kanno S, Nakashima I, Sato S, Fujihara K, Takata H, Nobukuni K, Kuroda S, Takano H, Umeda Y, Konno H, Nagasato K, Satoh A, Matsuda Y, Hidaka M, Takahashi H, Sano Y, Kim K, Konishi T, Doh-ura K, Sato T, Sasaki K, Nakamura Y, Yamada M, Mizusawa H, Itoyama Y
J Neurol. 2007
PubMed ID: 17965961
Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis.
Zabel MD, Heikenwalder M, Prinz M, Arrighi I, Schwarz P, Kranich J, von Teichman A, Haas KM, Zeller N, Tedder TF, Weis JH, Aguzzi A
J Immunol. 2007
PubMed ID: 17947689
Beta-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91-110 that recognise native PrPSc.
Khalili-Shirazi A, Kaisar M, Mallinson G, Jones S, Bhelt D, Fraser C, Clarke AR, Hawke SH, Jackson GS, Collinge J
Biochim Biophys Acta. 2007
PubMed ID: 17936697
Aquaporin 1 and aquaporin 4 overexpression in bovine spongiform encephalopathy in a transgenic murine model and in cattle field cases.
Costa C, Tortosa R, Rodríguez A, Ferrer I, Torres JM, Bassols A, Pumarola M
Brain Res. 2007
PubMed ID: 17868659
The neurochemical nature of PrP(c)-containing cells in the rat brain.
Moleres FJ, Velayos JL
Brain Res. 2007
PubMed ID: 17854776
Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a new prion strain.
Kobayashi A, Asano M, Mohri S, Kitamoto T
J Biol Chem. 2007
PubMed ID: 17709374
Interplays between covalent modifications in the endoplasmic reticulum increase conformational diversity in nascent prion protein.
Orsi A, Sitia R
Prion. 2007
PubMed ID: 19164910
Cellular prion protein regulates the motor behaviour performance and anxiety-induced responses in genetically modified mice.
Lobão-Soares B, Walz R, Carlotti CG, Sakamoto AC, Calvo F, Terzian AL, da Silva JA, Wichert-Ana L, Coimbra NC, Bianchin MM
Behav Brain Res. 2007
PubMed ID: 17618696
Bcl-2 overexpression delays caspase-3 activation and rescues cerebellar degeneration in prion-deficient mice that overexpress amino-terminally truncated prion.
Nicolas O, Gavín R, Braun N, Ureña JM, Fontana X, Soriano E, Aguzzi A, del Río JA
FASEB J. 2007
PubMed ID: 17494993
Cellular prion protein protects against reactive-oxygen-species-induced DNA damage.
Watt NT, Routledge MN, Wild CP, Hooper NM
Free Radic Biol Med. 2007
PubMed ID: 17697940
The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.
Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, Westaway D
EMBO J. 2007
PubMed ID: 17703189
Increased frequency of positive family history of dementia in sporadic CJD.
Krasnianski A, von Ahsen N, Heinemann U, Meissner B, Schulz-Schaeffer WJ, Kretzschmar HA, Armstrong VW, Zerr I
Neurobiol Aging. 2007
PubMed ID: 17822808
Normal cellular prion protein is a ligand of selectins: binding requires Le(X) but is inhibited by sLe(X).
Li C, Wong P, Pan T, Xiao F, Yin S, Chang B, Kang SC, Ironside J, Sy MS
Biochem J. 2007
PubMed ID: 17497959
Early onset fatal familial insomnia with rapid progression in a Chinese family line.
Yu S, Zhang Y, Li S, Sy MS, Sun S, Tien P, Xiao G
J Neurol. 2007
PubMed ID: 17385076
Enhanced susceptibility of Prnp-deficient mice to kainate-induced seizures, neuronal apoptosis, and death: Role of AMPA/kainate receptors.
Rangel A, Burgaya F, Gavín R, Soriano E, Aguzzi A, Del Río JA
J Neurosci Res. 2007
PubMed ID: 17304577
beta-Amyloid deposition and prion infection in adult primary brain cell long-term culture model.
Yun SW, Kouznetsova E, Nitschke C, Heinitz K, Schliebs R, Gerlach M, Riederer P, Klein MA
Biochem Biophys Res Commun. 2007
PubMed ID: 17612503
Inherited prion disease with 5-OPRI: phenotype modification by repeat length and codon 129.
Mead S, Webb TE, Campbell TA, Beck J, Linehan JM, Rutherfoord S, Joiner S, Wadsworth JD, Heckmann J, Wroe S, Doey L, King A, Collinge J
Neurology. 2007
PubMed ID: 17709704
A comparative molecular dynamics study on thermostability of human and chicken prion proteins.
Ji HF, Zhang HY
Biochem Biophys Res Commun. 2007
PubMed ID: 17560545
Characterization of the properties and trafficking of an anchorless form of the prion protein.
Campana V, Caputo A, Sarnataro D, Paladino S, Tivodar S, Zurzolo C
J Biol Chem. 2007
PubMed ID: 17556367
Species-specific differences in the intermediate states of human and Syrian hamster prion protein detected by high pressure NMR spectroscopy.
Kremer W, Kachel N, Kuwata K, Akasaka K, Kalbitzer HR
J Biol Chem. 2007
PubMed ID: 17519231
Cellular prion protein (PrPC) protects neuronal cells from the effect of huntingtin aggregation.
Lee KJ, Panzera A, Rogawski D, Greene LE, Eisenberg E
J Cell Sci. 2007
PubMed ID: 17635996
Late-onset olfactory deficits and mitral cell loss in mice lacking prion protein with ectopic expression of Doppel.
Kim CK, Sakudo A, Taniuchi Y, Shigematsu K, Kang CB, Saeki K, Matsumoto Y, Sakaguchi S, Itohara S, Onodera T
Int J Mol Med. 2007
PubMed ID: 17611634
Doppel induces degeneration of cerebellar Purkinje cells independently of Bax.
Dong J, Li A, Yamaguchi N, Sakaguchi S, Harris DA
Am J Pathol. 2007
PubMed ID: 17569776
Contributions of neuronal prion protein on sleep recovery and stress response following sleep deprivation.
Sánchez-Alavez M, Conti B, Moroncini G, Criado JR
Brain Res. 2007
PubMed ID: 17570349
Dual polarisation interferometry analysis of copper binding to the prion protein: evidence for two folding states.
Thompsett AR, Brown DR
Biochim Biophys Acta. 2007
PubMed ID: 17573247
Amyloid fibrils of mammalian prion protein induce axonal degeneration in NTERA2-derived terminally differentiated neurons.
Novitskaya V, Makarava N, Sylvester I, Bronstein IB, Baskakov IV
J Neurochem. 2007
PubMed ID: 17472702
Cellular prion protein promotes proliferation and G1/S transition of human gastric cancer cells SGC7901 and AGS.
Liang J, Pan Y, Zhang D, Guo C, Shi Y, Wang J, Chen Y, Wang X, Liu J, Guo X, Chen Z, Qiao T, Fan D
FASEB J. 2007
PubMed ID: 17409275
Scrapie infection of prion protein-deficient cell line upon ectopic expression of mutant prion proteins.
Maas E, Geissen M, Groschup MH, Rost R, Onodera T, Schätzl H, Vorberg IM
J Biol Chem. 2007
PubMed ID: 17468101
Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.
Parkin ET, Watt NT, Hussain I, Eckman EA, Eckman CB, Manson JC, Baybutt HN, Turner AJ, Hooper NM
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17573534
Association between the M129V variant allele of PRNP gene and mild temporal lobe epilepsy in women.
Labate A, Manna I, Gambardella A, Le Piane E, La Russa A, Condino F, Cittadella R, Aguglia U, Quattrone A
Neurosci Lett. 2007
PubMed ID: 17092648
Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice.
Li A, Piccardo P, Barmada SJ, Ghetti B, Harris DA
EMBO J. 2007
PubMed ID: 17510630
Involvement of cellular prion protein in the nociceptive response in mice.
Meotti FC, Carqueja CL, Gadotti Vde M, Tasca CI, Walz R, Santos AR
Brain Res. 2007
PubMed ID: 17433806
Diversity in neuroanatomical distribution of abnormal prion protein in atypical scrapie.
Nentwig A, Oevermann A, Heim D, Botteron C, Zellweger K, Drögemüller C, Zurbriggen A, Seuberlich T
PLoS Pathog. 2007
PubMed ID: 17559305
Polymorphisms at codons 129 and 219 of the prion protein gene (PRNP) are not associated with sporadic Alzheimer's disease in the Korean population.
Jeong BH, Lee KH, Jeong YE, Hwang KA, Lee YJ, Carp RI, Ju YR, Kim YS
Eur J Neurol. 2007
PubMed ID: 17539938
Motor behavioral and neuropathological deficits in mice deficient for normal prion protein expression.
Nazor KE, Seward T, Telling GC
Biochim Biophys Acta. 2007
PubMed ID: 17531449
Cellular prion protein interaction with vitronectin supports axonal growth and is compensated by integrins.
Hajj GN, Lopes MH, Mercadante AF, Veiga SS, da Silveira RB, Santos TG, Ribeiro KC, Juliano MA, Jacchieri SG, Zanata SM, Martins VR
J Cell Sci. 2007
PubMed ID: 17504807
Reduced susceptibility to bovine spongiform encephalopathy prions in transgenic mice expressing a bovine PrP with five octapeptide repeats.
Brun A, Gutiérrez-Adán A, Castilla J, Pintado B, Díaz-San Segundo F, Cano MJ, Alamillo E, Espinosa JC, Torres JM
J Gen Virol. 2007
PubMed ID: 17485546
Coenzyme Q and protein/lipid oxidation in a BSE-infected transgenic mouse model.
Martin SF, Burón I, Espinosa JC, Castilla J, Villalba JM, Torres JM
Free Radic Biol Med. 2007
PubMed ID: 17462540
CpG oligodeoxynucleotide-enhanced humoral immune response and production of antibodies to prion protein PrPSc in mice immunized with 139A scrapie-associated fibrils.
Spinner DS, Kascsak RB, Lafauci G, Meeker HC, Ye X, Flory MJ, Kim JI, Schuller-Levis GB, Levis WR, Wisniewski T, Carp RI, Kascsak RJ
J Leukoc Biol. 2007
PubMed ID: 17379700
Prion protein resides in membrane microclusters of the immunological synapse during lymphocyte activation.
Paar C, Wurm S, Pfarr W, Sonnleitner A, Wechselberger C
Eur J Cell Biol. 2007
PubMed ID: 17449139
Prion protein and the red cell.
Anstee DJ
Curr Opin Hematol. 2007
PubMed ID: 17414209
Changes in neuropeptide expression in mice infected with prions.
Diez M, Groth D, DeArmond SJ, Prusiner SB, Hökfelt T
Neurobiol Aging. 2007
PubMed ID: 16621165
Inducible overexpression of wild-type prion protein in the muscles leads to a primary myopathy in transgenic mice.
Huang S, Liang J, Zheng M, Li X, Wang M, Wang P, Vanegas D, Wu D, Chakraborty B, Hays AP, Chen K, Chen SG, Booth S, Cohen M, Gambetti P, Kong Q
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17420473
The role of the octarepeat region in neuroprotective function of the cellular prion protein.
Mitteregger G, Vosko M, Krebs B, Xiang W, Kohlmannsperger V, Nölting S, Hamann GF, Kretzschmar HA
Brain Pathol. 2007
PubMed ID: 17388948
Prion protein activates and fixes complement directly via the classical pathway: implications for the mechanism of scrapie agent propagation in lymphoid tissue.
Mitchell DA, Kirby L, Paulin SM, Villiers CL, Sim RB
Mol Immunol. 2007
PubMed ID: 17337056
Packaging of prions into exosomes is associated with a novel pathway of PrP processing.
Vella LJ, Sharples RA, Lawson VA, Masters CL, Cappai R, Hill AF
J Pathol. 2007
PubMed ID: 17334982
A 3-disulfide mutant of mouse prion protein expression, oxidative folding, reductive unfolding, conformational stability, aggregation and isomerization.
Lu BY, Chang JY
Arch Biochem Biophys. 2007
PubMed ID: 17320038
Developmental expression of PrP in the post-implantation embryo.
Tremblay P, Bouzamondo-Bernstein E, Heinrich C, Prusiner SB, DeArmond SJ
Brain Res. 2007
PubMed ID: 17292334
Human cellular prion protein hPrPC is sorted to the apical membrane of epithelial cells.
De Keukeleire B, Donadio S, Micoud J, Lechardeur D, Benharouga M
Biochem Biophys Res Commun. 2007
PubMed ID: 17276393
Site-specific conformational studies of prion protein (PrP) amyloid fibrils revealed two cooperative folding domains within amyloid structure.
Sun Y, Breydo L, Makarava N, Yang Q, Bocharova OV, Baskakov IV
J Biol Chem. 2007
PubMed ID: 17244617
Accumulation of prion protein in the brain that is not associated with transmissible disease.
Piccardo P, Manson JC, King D, Ghetti B, Barron RM
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360589
Immunohistochemical characterization of cell types expressing the cellular prion protein in the small intestine of cattle and mice.
Miyazawa K, Kanaya T, Tanaka S, Takakura I, Watanabe K, Ohwada S, Kitazawa H, Rose MT, Sakaguchi S, Katamine S, Yamaguchi T, Aso H
Histochem Cell Biol. 2007
PubMed ID: 17165097
Cellular prion protein is increased in the plasma and peri-infarcted brain tissue after acute stroke.
Mitsios N, Saka M, Krupinski J, Pennucci R, Sanfeliu C, Miguel Turu M, Gaffney J, Kumar P, Kumar S, Sullivan M, Slevin M
J Neurosci Res. 2007
PubMed ID: 17149767
Bending and unwinding of nucleic acid by prion protein.
Bera A, Roche AC, Nandi PK
Biochemistry. 2007
PubMed ID: 17260961
Two Norwegian sisters with late onset Creutzfeldt-Jakob disease caused by the E200K mutation.
Farbu E, Tysnes OB, Mørk S, Krossnes BK, Bindoff LA
J Neurol. 2007
PubMed ID: 17334659
Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice.
Mallucci GR, White MD, Farmer M, Dickinson A, Khatun H, Powell AD, Brandner S, Jefferys JG, Collinge J
Neuron. 2007
PubMed ID: 17270731
Altered prion protein glycosylation in the aging mouse brain.
Goh AX, Li C, Sy MS, Wong BS
J Neurochem. 2007
PubMed ID: 17144900
Temporal and spatial expression profiles of the Fat3 protein, a giant cadherin molecule, during mouse development.
Nagae S, Tanoue T, Takeichi M
Dev Dyn. 2007
PubMed ID: 17131403
Structural characterization of beta-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro.
Redecke L, von Bergen M, Clos J, Konarev PV, Svergun DI, Fittschen UE, Broekaert JA, Bruns O, Georgieva D, Mandelkow E, Genov N, Betzel C
J Struct Biol. 2007
PubMed ID: 17023178
Beta-sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange.
Lu X, Wintrode PL, Surewicz WK
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242357
N-terminally deleted forms of the prion protein activate both Bax-dependent and Bax-independent neurotoxic pathways.
Li A, Barmada SJ, Roth KA, Harris DA
J Neurosci. 2007
PubMed ID: 17251426
Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.
Li A, Christensen HM, Stewart LR, Roth KA, Chiesa R, Harris DA
EMBO J. 2007
PubMed ID: 17245437
Lethal recessive myelin toxicity of prion protein lacking its central domain.
Baumann F, Tolnay M, Brabeck C, Pahnke J, Kloz U, Niemann HH, Heikenwalder M, Rülicke T, Bürkle A, Aguzzi A
EMBO J. 2007
PubMed ID: 17245436
Nonpolar substitution at the C-terminus of the prion protein, a mimic of the glycosylphosphatidylinositol anchor, partially impairs amyloid fibril formation.
Breydo L, Sun Y, Makarava N, Lee CI, Novitskaia V, Bocharova O, Kao JP, Baskakov IV
Biochemistry. 2007
PubMed ID: 17223707
The C-terminal products of cellular prion protein processing, C1 and C2, exert distinct influence on p53-dependent staurosporine-induced caspase-3 activation.
Sunyach C, Cisse MA, da Costa CA, Vincent B, Checler F
J Biol Chem. 2007
PubMed ID: 17121821
Regulatory sequences of the PRNP gene influence susceptibility to sporadic Creutzfeldt-Jakob disease.
Bratosiewicz-Wasik J, Liberski PP, Golanska E, Jansen GH, Wasik TJ
Neurosci Lett. 2007
PubMed ID: 17134829
Is there a role for cellular prion protein in intrathymic T cell differentiation and migration?
Terra-Granado E, Berbert LR, de Meis J, Nomizo R, Martins VR, Savino W, Silva-Barbosa SD
Neuroimmunomodulation. 2007
PubMed ID: 18073517
Induced prion protein controls immune-activated retroviruses in the mouse spleen.
Lötscher M, Recher M, Lang KS, Navarini A, Hunziker L, Santimaria R, Glatzel M, Schwarz P, Böni J, Zinkernagel RM
PLoS ONE. 2007
PubMed ID: 17987132
Mutant prion protein D202N associated with familial prion disease is retained in the endoplasmic reticulum and forms 'curly' intracellular aggregates.
Gu Y, Verghese S, Bose S, Mohan M, Singh N
J Mol Neurosci. 2007
PubMed ID: 17873292
Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis.
Mack DL, Boulanger CA, Callahan R, Smith GH
Breast Cancer Res. 2007
PubMed ID: 17626637
Absence of association between codon 129 and 219 polymorphisms of the prion protein gene and vascular dementia.
Jeong BH, Na HR, Bae JC, Lee KH, Lee YJ, Kim NH, Song JH, Carp RI, Kim YS
Dement Geriatr Cogn Disord. 2007
PubMed ID: 17570906
Polymorphism distribution of prion protein codon 117, 129 and 171 in Taiwan.
Wang KC, Wang V, Sun MC, Chiueh TI, Soong BW, Shan DE
Eur J Epidemiol. 2007
PubMed ID: 17410475
Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro.
Thellung S, Corsaro A, Villa V, Venezia V, Nizzari M, Bisaglia M, Russo C, Schettini G, Aceto A, Florio T
Ann N Y Acad Sci. 2007
PubMed ID: 17405937
Prion protein aggregation and neurotoxicity in cortical neurons.
Melo JB, Agostinho P, Oliveira CR
Ann N Y Acad Sci. 2007
PubMed ID: 17405933
Cellular prion protein modulates the intracellular calcium response to hydrogen peroxide.
Krebs B, Wiebelitz A, Balitzki-Korte B, Vassallo N, Paluch S, Mitteregger G, Onodera T, Kretzschmar HA, Herms J
J Neurochem. 2007
PubMed ID: 17241158
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.
Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE
Nat Genet. 2007
PubMed ID: 17192785
Prion protein does not redox-silence Cu2+, but is a sacrificial quencher of hydroxyl radicals.
Nadal RC, Abdelraheim SR, Brazier MW, Rigby SE, Brown DR, Viles JH
Free Radic Biol Med. 2007
PubMed ID: 17157195
No association of prion protein gene polymorphisms with Alzheimer's disease in Korean population.
Ahn K, Kim E, Kwon YA, Kim DK, Lee JE, Jo SA
Exp Mol Med. 2006
PubMed ID: 17202849
Group I mGluR signaling in BSE-infected bovine-PrP transgenic mice.
Rodríguez A, Martín M, Albasanz JL, Barrachina M, Espinosa JC, Torres JM, Ferrer I
Neurosci Lett. 2006
PubMed ID: 17084974
Multiple forms of copper (II) co-ordination occur throughout the disordered N-terminal region of the prion protein at pH 7.4.
Wells MA, Jelinska C, Hosszu LL, Craven CJ, Clarke AR, Collinge J, Waltho JP, Jackson GS
Biochem J. 2006
PubMed ID: 16925523
The interaction between prion protein and laminin modulates memory consolidation.
Coitinho AS, Freitas AR, Lopes MH, Hajj GN, Roesler R, Walz R, Rossato JI, Cammarota M, Izquierdo I, Martins VR, Brentani RR
Eur J Neurosci. 2006
PubMed ID: 17156386
Prion protein prevents Bax-mediated cell death in the absence of other Bcl-2 family members in Saccharomyces cerevisiae.
Bounhar Y, Mann KK, Roucou X, LeBlanc AC
FEMS Yeast Res. 2006
PubMed ID: 17156017
Transmission and characterization of bovine spongiform encephalopathy sources in two ovine transgenic mouse lines (TgOvPrP4 and TgOvPrP59).
Cordier C, Bencsik A, Philippe S, Bétemps D, Ronzon F, Calavas D, Crozet C, Baron T
J Gen Virol. 2006
PubMed ID: 17098996
The prion protein is neuroprotective against retinal degeneration in vivo.
Frigg R, Wenzel A, Samardzija M, Oesch B, Wariwoda H, Navarini AA, Seeliger MW, Tanimoto N, Remé C, Grimm C
Exp Eye Res. 2006
PubMed ID: 16952355
Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome.
Gavin BA, Dolph MJ, Deleault NR, Geoghegan JC, Khurana V, Feany MB, Dolph PJ, Supattapone S
J Neurosci. 2006
PubMed ID: 17135402
Insoluble aggregates and protease-resistant conformers of prion protein in uninfected human brains.
Yuan J, Xiao X, McGeehan J, Dong Z, Cali I, Fujioka H, Kong Q, Kneale G, Gambetti P, Zou WQ
J Biol Chem. 2006
PubMed ID: 16987816
Junctional expression of the prion protein PrPC by brain endothelial cells: a role in trans-endothelial migration of human monocytes.
Viegas P, Chaverot N, Enslen H, Perrière N, Couraud PO, Cazaubon S
J Cell Sci. 2006
PubMed ID: 17062642
[The relationship between prion protein gene codon 129 polymorphism and Alzheimer's disease]
Qian HR, Wang LN, Zhu MW
Zhonghua Nei Ke Za Zhi. 2006
PubMed ID: 17313881
Prion protein expression by mouse dendritic cells is restricted to the nonplasmacytoid subsets and correlates with the maturation state.
Martínez del Hoyo G, López-Bravo M, Metharom P, Ardavín C, Aucouturier P
J Immunol. 2006
PubMed ID: 17056541
High frequency occurrence of 1-OPRD variant of PRNP gene in gastric cancer cell lines and Chinese population with gastric cancer.
Liang J, Wang JB, Pan YL, Wang J, Liu LL, Guo XY, Sun L, Lin T, Han S, Xie HH, Yin F, Guo XG, Fan D
Cell Biol Int. 2006
PubMed ID: 16914329
Prion protein gene M129 allele is a risk factor for Alzheimer's disease.
Gacia M, Safranow K, Styczyńska M, Jakubowska K, Pepłońska B, Chodakowska-Zebrowska M, Przekop I, Słowik A, Golańska E, Hułas-Bigoszewska K, Chlubek D, Religa D, Zekanowski C, Barcikowska M
J Neural Transm. 2006
PubMed ID: 16897605
Polymorphic microsatellite sites in the PRNP region point to excess of homozygotes in Creutzfeldt-Jakob disease patients.
Geldermann H, Bartenschlager H, Preuss S, Melchinger-Wild E, Herzog K, Zerr I
Gene. 2006
PubMed ID: 16889908
Clinicopathologic characteristics of sporadic Japanese Creutzfeldt-Jakob disease classified according to prion protein gene polymorphism and prion protein type.
Iwasaki Y, Yoshida M, Hashizume Y, Kitamoto T, Sobue G
Acta Neuropathol. 2006
PubMed ID: 16847689
A reassessment of copper(II) binding in the full-length prion protein.
Wells MA, Jackson GS, Jones S, Hosszu LL, Craven CJ, Clarke AR, Collinge J, Waltho JP
Biochem J. 2006
PubMed ID: 16824036
Dividing roles of prion protein in staurosporine-mediated apoptosis.
Zhang Y, Qin K, Wang J, Hung T, Zhao RY
Biochem Biophys Res Commun. 2006
PubMed ID: 16950206
Prion protein modifies TGF-beta induced signal transduction.
Wurm S, Wechselberger C
Biochem Biophys Res Commun. 2006
PubMed ID: 16942751
Computational comparison of cation coordination to human prion peptide models.
Riihimäki ES, Kloo L
Inorg Chem. 2006
PubMed ID: 17029361
Intracellular accumulation of a 46 kDa species of mouse prion protein as a result of loss of glycosylation in cultured mammalian cells.
Biswas S, Langeveld JP, Tipper D, Lu S
Biochem Biophys Res Commun. 2006
PubMed ID: 16935263
Prion protein inhibits microtubule assembly by inducing tubulin oligomerization.
Nieznanski K, Podlubnaya ZA, Nieznanska H
Biochem Biophys Res Commun. 2006
PubMed ID: 16934224
Prion protein 90-231 contains a streptavidin-binding motif.
Boetel T, Bade S, Schmidt MA, Frey A
Biochem Biophys Res Commun. 2006
PubMed ID: 16934221
Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein.
Orsi A, Fioriti L, Chiesa R, Sitia R
J Biol Chem. 2006
PubMed ID: 16908519
Significant association of a M129V independent polymorphism in the 5' UTR of the PRNP gene with sporadic Creutzfeldt-Jakob disease in a large German case-control study.
Vollmert C, Windl O, Xiang W, Rosenberger A, Zerr I, Wichmann HE, Bickeböller H, Illig T, KORA group, Kretzschmar HA
J Med Genet. 2006
PubMed ID: 17047093
Axotomy-induced motoneuron death is delayed in mice overexpressing PrPc.
Coulpier M, Messiaen S, Boucreaux D, Eloit M
Neuroscience. 2006
PubMed ID: 16843609
Formation of soluble oligomers and amyloid fibrils with physical properties of the scrapie isoform of the prion protein from the C-terminal domain of recombinant murine prion protein mPrP-(121-231).
Martins SM, Frosoni DJ, Martinez AM, De Felice FG, Ferreira ST
J Biol Chem. 2006
PubMed ID: 16844683
Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons.
Fuhrmann M, Bittner T, Mitteregger G, Haider N, Moosmang S, Kretzschmar H, Herms J
J Neurochem. 2006
PubMed ID: 16945105
Transmission of elk and deer prions to transgenic mice.
Tamgüney G, Giles K, Bouzamondo-Bernstein E, Bosque PJ, Miller MW, Safar J, DeArmond SJ, Prusiner SB
J Virol. 2006
PubMed ID: 16940522
The charge structure of helix 1 in the prion protein regulates conversion to pathogenic PrPSc.
Norstrom EM, Mastrianni JA
J Virol. 2006
PubMed ID: 16912302
Doppel-induced apoptosis and counteraction by cellular prion protein in neuroblastoma and astrocytes.
Qin K, Zhao L, Tang Y, Bhatta S, Simard JM, Zhao RY
Neuroscience. 2006
PubMed ID: 16766127
Rdj2, a J protein family member, interacts with cellular prion PrP(C).
Beck KE, Kay JG, Braun JE
Biochem Biophys Res Commun. 2006
PubMed ID: 16774738
Structural insights into the interaction between prion protein and nucleic acid.
Lima LM, Cordeiro Y, Tinoco LW, Marques AF, Oliveira CL, Sampath S, Kodali R, Choi G, Foguel D, Torriani I, Caughey B, Silva JL
Biochemistry. 2006
PubMed ID: 16866364
Codon 129 polymorphism of the human prion protein influences the kinetics of amyloid formation.
Lewis PA, Tattum MH, Jones S, Bhelt D, Batchelor M, Clarke AR, Collinge J, Jackson GS
J Gen Virol. 2006
PubMed ID: 16847141
Prion protein reduces both oxidative and non-oxidative copper toxicity.
Haigh CL, Brown DR
J Neurochem. 2006
PubMed ID: 16787422
Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP.
Rambold AS, Miesbauer M, Rapaport D, Bartke T, Baier M, Winklhofer KF, Tatzelt J
Mol Biol Cell. 2006
PubMed ID: 16707568
Interaction between the cellular prion (PrPC) and the 2P domain K+ channel TREK-1 protein.
Azzalin A, Ferrara V, Arias A, Cerri S, Avella D, Pisu MB, Nano R, Bernocchi G, Ferretti L, Comincini S
Biochem Biophys Res Commun. 2006
PubMed ID: 16750514
Acetylcholinesterase triggers the aggregation of PrP 106-126.
Pera M, Román S, Ratia M, Camps P, Muñoz-Torrero D, Colombo L, Manzoni C, Salmona M, Badia A, Clos MV
Biochem Biophys Res Commun. 2006
PubMed ID: 16750169
Influence of homozygosity for methionine at codon 129 of the human prion gene on the onset of neurological and hepatic symptoms in Wilson disease.
Merle U, Stremmel W, Gessner R
Arch Neurol. 2006
PubMed ID: 16831968
Immunohistochemical expression of prion protein (PrPC) in the human forebrain during development.
Adle-Biassette H, Verney C, Peoc'h K, Dauge MC, Razavi F, Choudat L, Gressens P, Budka H, Henin D
J Neuropathol Exp Neurol. 2006
PubMed ID: 16825956
Gerstmann-Sträussler-Scheinker: a new phenotype with 'curly' PrP deposits.
Colucci M, Moleres FJ, Xie ZL, Ray-Chaudhury A, Gutti S, Butefisch CM, Cervenakova L, Wang W, Goldfarb LG, Kong Q, Ghetti B, Chen SG, Gambetti P
J Neuropathol Exp Neurol. 2006
PubMed ID: 16825951
Role of cellular prion protein on LTP expression in aged mice.
Maglio LE, Martins VR, Izquierdo I, Ramirez OA
Brain Res. 2006
PubMed ID: 16730679
Prion protein protects against ethanol-induced Bax-mediated cell death in vivo.
Gains MJ, Roth KA, LeBlanc AC
Neuroreport. 2006
PubMed ID: 16738485
Functional implication of cellular prion protein in antigen-driven interactions between T cells and dendritic cells.
Ballerini C, Gourdain P, Bachy V, Blanchard N, Levavasseur E, Grégoire S, Fontes P, Aucouturier P, Hivroz C, Carnaud C
J Immunol. 2006
PubMed ID: 16751368
Probing the conformation of the prion protein within a single amyloid fibril using a novel immunoconformational assay.
Novitskaya V, Makarava N, Bellon A, Bocharova OV, Bronstein IB, Williamson RA, Baskakov IV
J Biol Chem. 2006
PubMed ID: 16569635
Prion protein in patients with renal failure.
Starke R, Mackie I, Drummond O, MacGregor I, Harrison P, Machin S
Transfus Med. 2006
PubMed ID: 16764594
Dichotomous versus palm-type mechanisms of lateral assembly of amyloid fibrils.
Makarava N, Bocharova OV, Salnikov VV, Breydo L, Anderson M, Baskakov IV
Protein Sci. 2006
PubMed ID: 16731968
Polymorphism of PRNP codons in the normal Icelandic population.
Georgsson G, Tryggvason T, Jonasdottir AD, Gudmundsson S, Thorgeirsdottir S
Acta Neurol Scand. 2006
PubMed ID: 16674609
Cellular isoform of the prion protein PrPc in human intestinal cell lines: genetic polymorphism at codon 129, mRNA quantification and protein detection in lipid rafts.
Garmy N, Guo XJ, Taïeb N, Tourrès C, Tamalet C, Fantini J, Yahi N
Cell Biol Int. 2006
PubMed ID: 16672189
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY
Cell. 2006
PubMed ID: 16713569
Cellular prion protein is released on exosomes from activated platelets.
Robertson C, Booth SA, Beniac DR, Coulthart MB, Booth TF, McNicol A
Blood. 2006
PubMed ID: 16434486
Amyloid fibrils of mammalian prion protein are highly toxic to cultured cells and primary neurons.
Novitskaya V, Bocharova OV, Bronstein I, Baskakov IV
J Biol Chem. 2006
PubMed ID: 16554307
The interaction between cytoplasmic prion protein and the hydrophobic lipid core of membrane correlates with neurotoxicity.
Wang X, Wang F, Arterburn L, Wollmann R, Ma J
J Biol Chem. 2006
PubMed ID: 16537534
Cognitive performance of patients with mesial temporal lobe epilepsy is not associated with human prion protein gene variant allele at codons 129 and 171.
Coimbra ER, Rezek K, Escorsi-Rosset S, Landemberger MC, Castro RM, Valadão MN, Guarnieri R, Velasco TR, Terra-Bustamante VC, Bianchin MM, Wichert-Ana L, Alexandre V, Brentani RR, Martins VR, Sakamoto AC, Walz R
Epilepsy Behav. 2006
PubMed ID: 16580884
Deletion of cellular prion protein results in reduced Akt activation, enhanced postischemic caspase-3 activation, and exacerbation of ischemic brain injury.
Weise J, Sandau R, Schwarting S, Crome O, Wrede A, Schulz-Schaeffer W, Zerr I, Bähr M
Stroke. 2006
PubMed ID: 16574930
Comparative genomic organization of the human and bovine PRNP locus.
Choi SH, Kim IC, Kim DS, Kim DW, Chae SH, Choi HH, Choi I, Yeo JS, Song MN, Park HS
Genomics. 2006
PubMed ID: 16460908
Is M129V of PRNP gene associated with Alzheimer's disease? A case-control study and a meta-analysis.
Del Bo R, Scarlato M, Ghezzi S, Martinelli-Boneschi F, Fenoglio C, Galimberti G, Galbiati S, Virgilio R, Galimberti D, Ferrarese C, Scarpini E, Bresolin N, Comi GP
Neurobiol Aging. 2006
PubMed ID: 16099550
Prion proteins with insertion mutations have altered N-terminal conformation and increased ligand binding activity and are more susceptible to oxidative attack.
Yin S, Yu S, Li C, Wong P, Chang B, Xiao F, Kang SC, Yan H, Xiao G, Grassi J, Tien P, Sy MS
J Biol Chem. 2006
PubMed ID: 16478730
Removal of the glycosylphosphatidylinositol anchor from PrP(Sc) by cathepsin D does not reduce prion infectivity.
Lewis PA, Properzi F, Prodromidou K, Clarke AR, Collinge J, Jackson GS
Biochem J. 2006
PubMed ID: 16441239
Putative aggregation initiation sites in prion protein.
Ziegler J, Viehrig C, Geimer S, Rösch P, Schwarzinger S
FEBS Lett. 2006
PubMed ID: 16545382
Prion protein gene codon 129 modulates clinical course of neurological Wilson disease.
Grubenbecher S, Stüve O, Hefter H, Korth C
Neuroreport. 2006
PubMed ID: 16543824
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Cell-specific metabolism and pathogenesis of transmembrane prion protein.
Gu Y, Luo X, Basu S, Fujioka H, Singh N
Mol Cell Biol. 2006
PubMed ID: 16537913
vCJD prion acquires altered virulence through trans-species infection.
Asano M, Mohri S, Ironside JW, Ito M, Tamaoki N, Kitamoto T
Biochem Biophys Res Commun. 2006
PubMed ID: 16480953
Role of N-terminal familial mutations in prion protein fibrillization and prion amyloid propagation in vitro.
Jones EM, Surewicz K, Surewicz WK
J Biol Chem. 2006
PubMed ID: 16443601
Overexpression of cellular prion protein induces an antioxidant environment altering T cell development in the thymus.
Jouvin-Marche E, Attuil-Audenis V, Aude-Garcia C, Rachidi W, Zabel M, Podevin-Dimster V, Siret C, Huber C, Martinic M, Riondel J, Villiers CL, Favier A, Naquet P, Cesbron JY, Marche PN
J Immunol. 2006
PubMed ID: 16517717
The determinants of stability in the human prion protein: insights into folding and misfolding from the analysis of the change in the stabilization energy distribution in different conditions.
Colacino S, Tiana G, Broglia RA, Colombo G
Proteins. 2006
PubMed ID: 16432880
The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations.
Scholz SW, Xiromerisiou G, Fung HC, Eerola J, Hellström O, Papadimitriou A, Hadjigeorgiou GM, Tienari PJ, Fernandez HH, Mandel R, Okun MS, Gwinn-Hardy K, Singleton AB
Neurosci Lett. 2006
PubMed ID: 16298483
Protease-resistant prion protein in lymphoreticular tumors of variant Creutzfeldt-Jakob disease mice.
Cervenakova L, Yakovleva O, McKenzie C
Emerg Infect Dis. 2006
PubMed ID: 16704797
Familial Creutzfeldt-Jakob disease with an R208H-129V haplotype and Kuru plaques.
Basset-Leobon C, Uro-Coste E, Peoc'h K, Haik S, Sazdovitch V, Rigal M, Andreoletti O, Hauw JJ, Delisle MB
Arch Neurol. 2006
PubMed ID: 16533975
Synthesis and structural characterization of a mimetic membrane-anchored prion protein.
Hicks MR, Gill AC, Bath IK, Rullay AK, Sylvester ID, Crout DH, Pinheiro TJ
FEBS J. 2006
PubMed ID: 16519692
Analysis of the polymorphic prion protein gene codon 129 in idiopathic Parkinson's disease.
Gossrau G, Herting B, Möckel S, Kempe A, Koch R, Reichmann H, Lampe JB
J Neural Transm. 2006
PubMed ID: 15997418
Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis.
Steele AD, Emsley JG, Ozdinler PH, Lindquist S, Macklis JD
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16492732
Synaptosomal glutamate release and uptake in mice lacking the cellular prion protein.
Thais ME, Carqueja CL, Santos TG, Silva RV, Stroeh E, Machado RS, Wahlheim DO, Bianchin MM, Sakamoto AC, Brentani RR, Martins VR, Walz R, Tasca CI
Brain Res. 2006
PubMed ID: 16519879
GFP-tagged PrP supports compromised prion replication in transgenic mice.
Bian J, Nazor KE, Angers R, Jernigan M, Seward T, Centers A, Green M, Telling GC
Biochem Biophys Res Commun. 2006
PubMed ID: 16386707
Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal.
Zhang CC, Steele AD, Lindquist S, Lodish HF
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16467153
Prion protein induced signaling cascades in monocytes.
Krebs B, Dorner-Ciossek C, Schmalzbauer R, Vassallo N, Herms J, Kretzschmar HA
Biochem Biophys Res Commun. 2006
PubMed ID: 16343423
The prion protein requires cholesterol for cell surface localization.
Gilch S, Kehler C, Schätzl HM
Mol Cell Neurosci. 2006
PubMed ID: 16278084
Annealing prion protein amyloid fibrils at high temperature results in extension of a proteinase K-resistant core.
Bocharova OV, Makarava N, Breydo L, Anderson M, Salnikov VV, Baskakov IV
J Biol Chem. 2006
PubMed ID: 16314415
Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model.
Gobbi M, Colombo L, Morbin M, Mazzoleni G, Accardo E, Vanoni M, Del Favero E, Cantù L, Kirschner DA, Manzoni C, Beeg M, Ceci P, Ubezio P, Forloni G, Tagliavini F, Salmona M
J Biol Chem. 2006
PubMed ID: 16286452
Prion genotypes in Central America suggest selection for the V129 allele.
Hardy J, Scholz S, Evans W, Goldfarb L, Singleton A
Am J Med Genet B Neuropsychiatr Genet. 2006
PubMed ID: 16287045
Autopsy-proven Creutzfeldt-Jakob disease with a codon 180 mutation showing dissociation between diffusion-weighted magnetic resonance imaging and single-photon emission computed tomography findings: Is this a suggestive finding in long survival?
Shindo K, Shimokawa C, Ohta E, Inada H, Togashi S, Nitta K, Nagasaka T, Kato R, Kobayashi M, Shiozawa Z
Eur Neurol. 2006
PubMed ID: 16921242
Exclusion of mutations in the PRNP, JPH3, TBP, ATN1, CREBBP, POU3F2 and FTL genes as a cause of disease in Portuguese patients with a Huntington-like phenotype.
Costa Mdo C, Teixeira-Castro A, Constante M, Magalhães M, Magalhães P, Cerqueira J, Vale J, Passão V, Barbosa C, Robalo C, Coutinho P, Barros J, Santos MM, Sequeiros J, Maciel P
J Hum Genet. 2006
PubMed ID: 16858508
Overexpression of PrPC and its antiapoptosis function in gastric cancer.
Liang J, Pan YL, Ning XX, Sun LJ, Lan M, Hong L, Du JP, Liu N, Liu CJ, Qiao TD, Fan DM
Tumour Biol. 2006
PubMed ID: 16582585
Analysis of PRNP gene codon 129 polymorphism in the Greek population.
Saetta AA, Michalopoulos NV, Malamis G, Papanastasiou PI, Mazmanian N, Karlou M, Kouzoupis A, Korkolopoulou P, Patsouris E
Eur J Epidemiol. 2006
PubMed ID: 16547836
Fusion of Doppel to octapeptide repeat and N-terminal half of hydrophobic region of prion protein confers resistance to serum deprivation.
Lee DC, Sakudo A, Kim CK, Nishimura T, Saeki K, Matsumoto Y, Yokoyama T, Chen SG, Itohara S, Onodera T
Microbiol Immunol. 2006
PubMed ID: 16547418
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Identification of prion protein binding proteins by combined use of far-Western immunoblotting, two dimensional gel electrophoresis and mass spectrometry.
Strom A, Diecke S, Hunsmann G, Stuke AW
Proteomics. 2006
PubMed ID: 16294306
Induction of cellular prion protein gene expression by copper in neurons.
Varela-Nallar L, Toledo EM, Larrondo LF, Cabral AL, Martins VR, Inestrosa NC
Am J Physiol Cell Physiol. 2006
PubMed ID: 16148034
High affinity binding between copper and full-length prion protein identified by two different techniques.
Thompsett AR, Abdelraheim SR, Daniels M, Brown DR
J Biol Chem. 2005
PubMed ID: 16258172
Altered glycosylated PrP proteins can have different neuronal trafficking in brain but do not acquire scrapie-like properties.
Cancellotti E, Wiseman F, Tuzi NL, Baybutt H, Monaghan P, Aitchison L, Simpson J, Manson JC
J Biol Chem. 2005
PubMed ID: 16219759
Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.
McCracken S, Longman D, Marcon E, Moens P, Downey M, Nickerson JA, Jessberger R, Wilde A, Caceres JF, Emili A, Blencowe BJ
J Biol Chem. 2005
PubMed ID: 16159877
Definable equilibrium states in the folding of human prion protein.
Hosszu LL, Wells MA, Jackson GS, Jones S, Batchelor M, Clarke AR, Craven CJ, Waltho JP, Collinge J
Biochemistry. 2005
PubMed ID: 16342955
Interaction of cellular prion and stress-inducible protein 1 promotes neuritogenesis and neuroprotection by distinct signaling pathways.
Lopes MH, Hajj GN, Muras AG, Mancini GL, Castro RM, Ribeiro KC, Brentani RR, Linden R, Martins VR
J Neurosci. 2005
PubMed ID: 16339028
Creutzfeldt-Jakob disease risk and PRNP codon 129 polymorphism: necessity to revalue current data.
Mitrová E, Mayer V, Jovankovicová V, Slivarichová D, Wsólová L
Eur J Neurol. 2005
PubMed ID: 16324095
Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia.
Li X, Rowland LP, Mitsumoto H, Przedborski S, Bird TD, Schellenberg GD, Peskind E, Johnson N, Siddique T, Mesulam MM, Weintraub S, Mastrianni JA
Ann Neurol. 2005
PubMed ID: 16315279
Creutzfeldt-Jakob disease (CJD) with a mutation at codon 148 of prion protein gene: relationship with sporadic CJD.
Pastore M, Chin SS, Bell KL, Dong Z, Yang Q, Yang L, Yuan J, Chen SG, Gambetti P, Zou WQ
Am J Pathol. 2005
PubMed ID: 16314483
Breaking an absolute species barrier: transgenic mice expressing the mink PrP gene are susceptible to transmissible mink encephalopathy.
Windl O, Buchholz M, Neubauer A, Schulz-Schaeffer W, Groschup M, Walter S, Arendt S, Neumann M, Voss AK, Kretzschmar HA
J Virol. 2005
PubMed ID: 16282497
Association of sporadic Creutzfeldt-Jakob disease with homozygous genotypes at PRNP codons 129 and 219 in the Korean population.
Jeong BH, Lee KH, Kim NH, Jin JK, Kim JI, Carp RI, Kim YS
Neurogenetics. 2005
PubMed ID: 16217673
Recombinant prion protein does not possess SOD-1 activity.
Jones S, Batchelor M, Bhelt D, Clarke AR, Collinge J, Jackson GS
Biochem J. 2005
PubMed ID: 16156720
The metabolism of glycosaminoglycans is impaired in prion diseases.
Mayer-Sonnenfeld T, Zeigler M, Halimi M, Dayan Y, Herzog C, Lasmezas CI, Gabizon R
Neurobiol Dis. 2005
PubMed ID: 15951190
The N-terminal cleavage of cellular prion protein in the human brain.
Laffont-Proust I, Faucheux BA, Hässig R, Sazdovitch V, Simon S, Grassi J, Hauw JJ, Moya KL, Haïk S
FEBS Lett. 2005
PubMed ID: 16263114
Disease-related prion protein forms aggresomes in neuronal cells leading to caspase activation and apoptosis.
Kristiansen M, Messenger MJ, Klöhn PC, Brandner S, Wadsworth JD, Collinge J, Tabrizi SJ
J Biol Chem. 2005
PubMed ID: 16157591
The murine B cell repertoire is severely selected against endogenous cellular prion protein.
Grégoire S, Bergot AS, Féraudet C, Carnaud C, Aucouturier P, Rosset MB
J Immunol. 2005
PubMed ID: 16272297
Transgenic mice expressing bovine PrP with a four extra repeat octapeptide insert mutation show a spontaneous, non-transmissible, neurodegenerative disease and an expedited course of BSE infection.
Castilla J, Gutiérrez-Adán A, Brun A, Pintado B, Salguero FJ, Parra B, Segundo FD, Ramírez MA, Rábano A, Cano MJ, Torres JM
FEBS Lett. 2005
PubMed ID: 16253245
Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis.
Taylor DR, Watt NT, Perera WS, Hooper NM
J Cell Sci. 2005
PubMed ID: 16254249
The membrane environment of endogenous cellular prion protein in primary rat cerebellar neurons.
Loberto N, Prioni S, Bettiga A, Chigorno V, Prinetti A, Sonnino S
J Neurochem. 2005
PubMed ID: 16248888
A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes.
Le Dur A, Béringue V, Andréoletti O, Reine F, Laï TL, Baron T, Bratberg B, Vilotte JL, Sarradin P, Benestad SL, Laude H
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16239348
Genetic prion disease: the EUROCJD experience.
Kovács GG, Puopolo M, Ladogana A, Pocchiari M, Budka H, van Duijn C, Collins SJ, Boyd A, Giulivi A, Coulthart M, Delasnerie-Laupretre N, Brandel JP, Zerr I, Kretzschmar HA, de Pedro-Cuesta J, Calero-Lara M, Glatzel M, Aguzzi A, Bishop M, Knight R, Belay G, Will R, Mitrova E, EUROCJD
Hum Genet. 2005
PubMed ID: 16187142
Neuropathologic characteristics of spinal cord lesions in sporadic Creutzfeldt-Jakob disease.
Iwasaki Y, Yoshida M, Hashizume Y, Kitamoto T, Sobue G
Acta Neuropathol. 2005
PubMed ID: 16175355
Proper axonal distribution of PrP(C) depends on cholesterol-sphingomyelin-enriched membrane domains and is developmentally regulated in hippocampal neurons.
Galvan C, Camoletto PG, Dotti CG, Aguzzi A, Ledesma MD
Mol Cell Neurosci. 2005
PubMed ID: 16139509
Aggravation of ischemic brain injury by prion protein deficiency: role of ERK-1/-2 and STAT-1.
Spudich A, Frigg R, Kilic E, Kilic U, Oesch B, Raeber A, Bassetti CL, Hermann DM
Neurobiol Dis. 2005
PubMed ID: 15893468
Reactive oxygen species-mediated beta-cleavage of the prion protein in the cellular response to oxidative stress.
Watt NT, Taylor DR, Gillott A, Thomas DA, Perera WS, Hooper NM
J Biol Chem. 2005
PubMed ID: 16120605
Sporadic Creutzfeldt-Jakob disease: the extent of microglia activation is dependent on the biochemical type of PrPSc.
Puoti G, Giaccone G, Mangieri M, Limido L, Fociani P, Zerbi P, Suardi S, Rossi G, Iussich S, Capobianco R, Di Fede G, Marcon G, Cotrufo R, Filippini G, Bugiani O, Tagliavini F
J Neuropathol Exp Neurol. 2005
PubMed ID: 16215462
The 14-3-3 protein forms a molecular complex with heat shock protein Hsp60 and cellular prion protein.
Satoh J, Onoue H, Arima K, Yamamura T
J Neuropathol Exp Neurol. 2005
PubMed ID: 16215457
Absence of evidence for the participation of the macrophage cellular prion protein in infection with Brucella suis.
Fontes P, Alvarez-Martinez MT, Gross A, Carnaud C, Köhler S, Liautard JP
Infect Immun. 2005
PubMed ID: 16177294
An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimers and PrP(Sc) aggregates.
Pan T, Chang B, Wong P, Li C, Li R, Kang SC, Robinson JD, Thompsett AR, Tein P, Yin S, Barnard G, McConnell I, Brown DR, Wisniewski T, Sy MS
J Virol. 2005
PubMed ID: 16160162
Copper binding is the governing determinant of prion protein turnover.
Haigh CL, Edwards K, Brown DR
Mol Cell Neurosci. 2005
PubMed ID: 16084105
Overexpression of PrPC by adenovirus-mediated gene targeting reduces ischemic injury in a stroke rat model.
Shyu WC, Lin SZ, Chiang MF, Ding DC, Li KW, Chen SF, Yang HI, Li H
J Neurosci. 2005
PubMed ID: 16192387
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Purification of normal cellular prion protein from human platelets and the formation of a high molecular weight prion protein complex following platelet activation.
Jones M, Head MW, Connolly JG, Farquhar CF, Hornsey VS, Pepper DS, MacGregor IR
Biochem Biophys Res Commun. 2005
PubMed ID: 16051190
The octarepeat domain of the prion protein binds Cu(II) with three distinct coordination modes at pH 7.4.
Chattopadhyay M, Walter ED, Newell DJ, Jackson PJ, Aronoff-Spencer E, Peisach J, Gerfen GJ, Bennett B, Antholine WE, Millhauser GL
J Am Chem Soc. 2005
PubMed ID: 16144413
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
PrP glycoforms are associated in a strain-specific ratio in native PrPSc.
Khalili-Shirazi A, Summers L, Linehan J, Mallinson G, Anstee D, Hawke S, Jackson GS, Collinge J
J Gen Virol. 2005
PubMed ID: 16099923
Gerstmann-Sträussler-Scheinker disease with the Q217R mutation mimicking frontotemporal dementia.
Woulfe J, Kertesz A, Frohn I, Bauer S, George-Hyslop PS, Bergeron C
Acta Neuropathol. 2005
PubMed ID: 16025285
Chronic wasting disease of elk: transmissibility to humans examined by transgenic mouse models.
Kong Q, Huang S, Zou W, Vanegas D, Wang M, Wu D, Yuan J, Zheng M, Bai H, Deng H, Chen K, Jenny AL, O'Rourke K, Belay ED, Schonberger LB, Petersen RB, Sy MS, Chen SG, Gambetti P
J Neurosci. 2005
PubMed ID: 16135751
Direct interaction between prion protein and tubulin.
Nieznanski K, Nieznanska H, Skowronek KJ, Osiecka KM, Stepkowski D
Biochem Biophys Res Commun. 2005
PubMed ID: 16004966
Absence of mutations in the prion-protein gene in a large cohort of HMSN patients.
Koop O, Timmerman V, de Jonghe P, Ringelstein B, Young P, Kuhlenbäumer G
Neuromuscul Disord. 2005
PubMed ID: 16009550
The prion gene is associated with human long-term memory.
Papassotiropoulos A, Wollmer MA, Aguzzi A, Hock C, Nitsch RM, de Quervain DJ
Hum Mol Genet. 2005
PubMed ID: 15987701
Prion protein (PrPc) promotes beta-amyloid plaque formation.
Schwarze-Eicker K, Keyvani K, Görtz N, Westaway D, Sachser N, Paulus W
Neurobiol Aging. 2005
PubMed ID: 15917101
Altered behavioural response to acute stress in mice lacking cellular prion protein.
Nico PB, de-Paris F, Vinadé ER, Amaral OB, Rockenbach I, Soares BL, Guarnieri R, Wichert-Ana L, Calvo F, Walz R, Izquierdo I, Sakamoto AC, Brentani R, Martins VR, Bianchin MM
Behav Brain Res. 2005
PubMed ID: 15970215
Cell-autonomous PrP-Doppel interaction regulates apoptosis in PrP gene-deficient neuronal cells.
Sakudo A, Lee DC, Nakamura I, Taniuchi Y, Saeki K, Matsumoto Y, Itohara S, Ikuta K, Onodera T
Biochem Biophys Res Commun. 2005
PubMed ID: 15950943
Nitric oxide induces prion protein via MEK and p38 MAPK signaling.
Wang V, Chuang TC, Hsu YD, Chou WY, Kao MC
Biochem Biophys Res Commun. 2005
PubMed ID: 15936714
The AGAAAAGA palindrome in PrP is required to generate a productive PrPSc-PrPC complex that leads to prion propagation.
Norstrom EM, Mastrianni JA
J Biol Chem. 2005
PubMed ID: 15917252
Immunodetection of disease-associated mutant PrP, which accelerates disease in GSS transgenic mice.
Nazor KE, Kuhn F, Seward T, Green M, Zwald D, Pürro M, Schmid J, Biffiger K, Power AM, Oesch B, Raeber AJ, Telling GC
EMBO J. 2005
PubMed ID: 15962001
Scrg1 is induced in TSE and brain injuries, and associated with autophagy.
Dron M, Bailly Y, Beringue V, Haeberlé AM, Griffond B, Risold PY, Tovey MG, Laude H, Dandoy-Dron F
Eur J Neurosci. 2005
PubMed ID: 16029203
Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells.
Roucou X, Giannopoulos PN, Zhang Y, Jodoin J, Goodyer CG, LeBlanc A
Cell Death Differ. 2005
PubMed ID: 15846375
Amidation and structure relaxation abolish the neurotoxicity of the prion peptide PrP106-126 in vivo and in vitro.
Bergström AL, Cordes H, Zsurger N, Heegaard PM, Laursen H, Chabry J
J Biol Chem. 2005
PubMed ID: 15824101
Anchorless prion protein results in infectious amyloid disease without clinical scrapie.
Chesebro B, Trifilo M, Race R, Meade-White K, Teng C, LaCasse R, Raymond L, Favara C, Baron G, Priola S, Caughey B, Masliah E, Oldstone M
Science. 2005
PubMed ID: 15933194
The expression of prion protein (PrP(C)) in the megakaryocyte lineage.
Starke R, Harrison P, Mackie I, Wang G, Erusalimsky JD, Gale R, Massé JM, Cramer E, Pizzey A, Biggerstaff J, Machin S
J Thromb Haemost. 2005
PubMed ID: 15946217
Interaction of PrP with NRAGE, a protein involved in neuronal apoptosis.
Bragason BT, Palsdottir A
Mol Cell Neurosci. 2005
PubMed ID: 15911347
A cylinder-shaped double ribbon structure formed by an amyloid hairpin peptide derived from the beta-sheet of murine PrP: an X-ray and molecular dynamics simulation study.
Croixmarie V, Briki F, David G, Coïc YM, Ovtracht L, Doucet J, Jamin N, Sanson A
J Struct Biol. 2005
PubMed ID: 15890277
Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons.
Criado JR, Sánchez-Alavez M, Conti B, Giacchino JL, Wills DN, Henriksen SJ, Race R, Manson JC, Chesebro B, Oldstone MB
Neurobiol Dis. 2005
PubMed ID: 15837581
Truncated prion protein and Doppel are myelinotoxic in the absence of oligodendrocytic PrPC.
Radovanovic I, Braun N, Giger OT, Mertz K, Miele G, Prinz M, Navarro B, Aguzzi A
J Neurosci. 2005
PubMed ID: 15888663
Purkinje-cell degeneration in prion protein-deficient mice is associated with a cerebellum-specific Doppel protein species signature.
Al Bersaoui R, Robert I, Lutz Y, Blanc F, Sommermeyer-Leroux G, Shibaguchi H, Aunis D, Fuchs JP
FEBS Lett. 2005
PubMed ID: 15862314
The presence of valine at residue 129 in human prion protein accelerates amyloid formation.
Baskakov I, Disterer P, Breydo L, Shaw M, Gill A, James W, Tahiri-Alaoui A
FEBS Lett. 2005
PubMed ID: 15862295
[Prion protein and copper: a mysterious relationship]
Rachidi W, Riondel J, McMahon HM, Favier A
Pathol Biol (Paris). 2005
PubMed ID: 15850959
Transmission barriers for bovine, ovine, and human prions in transgenic mice.
Scott MR, Peretz D, Nguyen HO, Dearmond SJ, Prusiner SB
J Virol. 2005
PubMed ID: 15827140
Mammalian prion protein suppresses Bax-induced cell death in yeast.
Li A, Harris DA
J Biol Chem. 2005
PubMed ID: 15753097
Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth.
Santuccione A, Sytnyk V, Leshchyns'ka I, Schachner M
J Cell Biol. 2005
PubMed ID: 15851519
A transmembrane form of the prion protein is localized in the Golgi apparatus of neurons.
Stewart RS, Harris DA
J Biol Chem. 2005
PubMed ID: 15671025
Comparative analysis of the human and chicken prion protein copper binding regions at pH 6.5.
Redecke L, Meyer-Klaucke W, Koker M, Clos J, Georgieva D, Genov N, Echner H, Kalbacher H, Perbandt M, Bredehorst R, Voelter W, Betzel C
J Biol Chem. 2005
PubMed ID: 15684434
Comparative study of PrPc expression in rat, monkey, and cow gastrointestinal tract.
Marcos Z, Bodegas ME, Sesma MP, Guembe L
Ann N Y Acad Sci. 2005
PubMed ID: 15891070
Circumventing tolerance to the prion protein (PrP): vaccination with PrP-displaying retrovirus particles induces humoral immune responses against the native form of cellular PrP.
Nikles D, Bach P, Boller K, Merten CA, Montrasio F, Heppner FL, Aguzzi A, Cichutek K, Kalinke U, Buchholz CJ
J Virol. 2005
PubMed ID: 15767405
Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein.
Stewart RS, Piccardo P, Ghetti B, Harris DA
J Neurosci. 2005
PubMed ID: 15800202
Glycosylation-related gene expression in prion diseases: PrPSc accumulation in scrapie infected GT1 cells depends on beta-1,4-linked GalNAc-4-SO4 hyposulfation.
Barret A, Forestier L, Deslys JP, Julien R, Gallet PF
J Biol Chem. 2005
PubMed ID: 15632154
Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor.
Kiachopoulos S, Bracher A, Winklhofer KF, Tatzelt J
J Biol Chem. 2005
PubMed ID: 15591591
An unusual soluble beta-turn-rich conformation of prion is involved in fibril formation and toxic to neuronal cells.
Kazlauskaite J, Young A, Gardner CE, Macpherson JV, Vénien-Bryan C, Pinheiro TJ
Biochem Biophys Res Commun. 2005
PubMed ID: 15670783
PrP cooperates with STI1 to regulate SOD activity in PrP-deficient neuronal cell line.
Sakudo A, Lee DC, Li S, Nakamura T, Matsumoto Y, Saeki K, Itohara S, Ikuta K, Onodera T
Biochem Biophys Res Commun. 2005
PubMed ID: 15670743
Normal brain mitochondrial respiration in adult mice lacking cellular prion protein.
Lobão-Soares B, Bianchin MM, Linhares MN, Carqueja CL, Tasca CI, Souza M, Marques W, Brentani R, Martins VR, Sakamoto AC, Carlotti CG, Walz R
Neurosci Lett. 2005
PubMed ID: 15694261
Combined pharmacological, mutational and cell biology approaches indicate that p53-dependent caspase 3 activation triggered by cellular prion is dependent on its endocytosis.
Sunyach C, Checler F
J Neurochem. 2005
PubMed ID: 15748158
The population distribution of the Met allele at the PRNP129 polymorphism (a high risk factor for Creutzfeldt-Jakob disease) in various regions of France and in West Europe.
Lucotte G, Mercier G
Infect Genet Evol. 2005
PubMed ID: 15639746
In vitro conversion of mammalian prion protein into amyloid fibrils displays unusual features.
Baskakov IV, Bocharova OV
Biochemistry. 2005
PubMed ID: 15709746
In vitro conversion of full-length mammalian prion protein produces amyloid form with physical properties of PrP(Sc).
Bocharova OV, Breydo L, Parfenov AS, Salnikov VV, Baskakov IV
J Mol Biol. 2005
PubMed ID: 15670611
A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein.
Uelhoff A, Tatzelt J, Aguzzi A, Winklhofer KF, Haass C
J Biol Chem. 2005
PubMed ID: 15615717
Binding of recombinant PrPc to human plasminogen: kinetic and thermodynamic study using a resonant mirror biosensor.
Cuccioloni M, Amici M, Eleuteri AM, Biagetti M, Barocci S, Angeletti M
Proteins. 2005
PubMed ID: 15609351
The cellular prion protein modulates phagocytosis and inflammatory response.
de Almeida CJ, Chiarini LB, da Silva JP, E Silva PM, Martins MA, Linden R
J Leukoc Biol. 2005
PubMed ID: 15539455
Octapeptide repeat region and N-terminal half of hydrophobic region of prion protein (PrP) mediate PrP-dependent activation of superoxide dismutase.
Sakudo A, Lee DC, Nishimura T, Li S, Tsuji S, Nakamura T, Matsumoto Y, Saeki K, Itohara S, Ikuta K, Onodera T
Biochem Biophys Res Commun. 2005
PubMed ID: 15596141
Pathological prion protein exposure switches on neuronal mitogen-activated protein kinase pathway resulting in microglia recruitment.
Marella M, Gaggioli C, Batoz M, Deckert M, Tartare-Deckert S, Chabry J
J Biol Chem. 2005
PubMed ID: 15528202
Female-specific neuroprotection against transient brain ischemia observed in mice devoid of prion protein is abolished by ectopic expression of prion protein-like protein.
Sakurai-Yamashita Y, Sakaguchi S, Yoshikawa D, Okimura N, Masuda Y, Katamine S, Niwa M
Neuroscience. 2005
PubMed ID: 16198494
Genotype frequencies at codon 129 of the prion protein gene in Brazil: Implications in susceptibility to variant Creutzfeldt-Jakob disease compared to European and Asian populations.
de Paula EV, Addas-Carvalho M, Costa DS, Saad ST, Gilli SC
Eur J Epidemiol. 2005
PubMed ID: 16119432
Presymptomatic signs in healthy CJD mutation carriers.
Gigi A, Vakil E, Kahana E, Hadar U
Dement Geriatr Cogn Disord. 2005
PubMed ID: 15775715
The neurotoxicity of prion protein (PrP) peptide 106-126 is independent of the expression level of PrP and is not mediated by abnormal PrP species.
Fioriti L, Quaglio E, Massignan T, Colombo L, Stewart RS, Salmona M, Harris DA, Forloni G, Chiesa R
Mol Cell Neurosci. 2005
PubMed ID: 15607951
Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.
Drisaldi B, Coomaraswamy J, Mastrangelo P, Strome B, Yang J, Watts JC, Chishti MA, Marvi M, Windl O, Ahrens R, Major F, Sy MS, Kretzschmar H, Fraser PE, Mount HT, Westaway D
J Biol Chem. 2004
PubMed ID: 15459186
Synthetic human prion protein octapeptide repeat binds to the proteinase K active site.
Georgieva D, Rypniewski W, Echner H, Perbandt M, Koker M, Clos J, Redecke L, Bredehorst R, Voelter W, Genov N, Betzel C
Biochem Biophys Res Commun. 2004
PubMed ID: 15555583
A neurogenomics approach to gene expression analysis in the developing brain.
Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T
Brain Res Mol Brain Res. 2004
PubMed ID: 15582152
Glycosylation deficiency at either one of the two glycan attachment sites of cellular prion protein preserves susceptibility to bovine spongiform encephalopathy and scrapie infections.
Neuendorf E, Weber A, Saalmueller A, Schatzl H, Reifenberg K, Pfaff E, Groschup MH
J Biol Chem. 2004
PubMed ID: 15448157
Gene expression profiling in chronic copper overload reveals upregulation of Prnp and App.
Armendariz AD, Gonzalez M, Loguinov AV, Vulpe CD
Physiol Genomics. 2004
PubMed ID: 15467011
Human prion protein with valine 129 prevents expression of variant CJD phenotype.
Wadsworth JD, Asante EA, Desbruslais M, Linehan JM, Joiner S, Gowland I, Welch J, Stone L, Lloyd SE, Hill AF, Brandner S, Collinge J
Science. 2004
PubMed ID: 15539564
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Modulation of signal transduction through the cellular prion protein is linked to its incorporation in lipid rafts.
Hugel B, Martínez MC, Kunzelmann C, Blättler T, Aguzzi A, Freyssinet JM
Cell Mol Life Sci. 2004
PubMed ID: 15583862
Hippocampal synaptic plasticity in mice devoid of cellular prion protein.
Maglio LE, Perez MF, Martins VR, Brentani RR, Ramirez OA
Brain Res Mol Brain Res. 2004
PubMed ID: 15530652
Creutzfeldt-Jakob disease with a novel insertion and codon 219 Lys/Lys polymorphism in PRNP.
Nishida Y, Sodeyama N, Toru Y, Toru S, Kitamoto T, Mizusawa H
Neurology. 2004
PubMed ID: 15557533
Prion replication alters the distribution of synaptophysin and caveolin 1 in neuronal lipid rafts.
Russelakis-Carneiro M, Hetz C, Maundrell K, Soto C
Am J Pathol. 2004
PubMed ID: 15509552
High capacity and low cost detection of prion protein gene variant alleles by denaturing HPLC.
Castro RM, Landemberger MC, Walz R, Carlotti CG, Huang N, Cunha DR, Moura R, Caballero OL, Sakamoto AC, Nitrini R, Brentani RR, Martins VR
J Neurosci Methods. 2004
PubMed ID: 15488240
Probing the instabilities in the dynamics of helical fragments from mouse PrPC.
Dima RI, Thirumalai D
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15494440
Prion protein protects against DNA damage induced by paraquat in cultured cells.
Senator A, Rachidi W, Lehmann S, Favier A, Benboubetra M
Free Radic Biol Med. 2004
PubMed ID: 15451062
Cellular prion protein regulates intracellular hydrogen peroxide level and prevents copper-induced apoptosis.
Nishimura T, Sakudo A, Nakamura I, Lee DC, Taniuchi Y, Saeki K, Matsumoto Y, Ogawa M, Sakaguchi S, Itohara S, Onodera T
Biochem Biophys Res Commun. 2004
PubMed ID: 15351724
Expression of Prnp mRNA (prion protein gene) in mouse spermatogenic cells.
Fujisawa M, Kanai Y, Nam SY, Maeda S, Nakamuta N, Kano K, Kurohmaru M, Hayashi Y
J Reprod Dev. 2004
PubMed ID: 15514463
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Clinical and genetic features of human prion diseases in Catalonia: 1993-2002.
Sanchez-Valle R, Nos C, Yagüe J, Graus F, Domínguez A, Saiz A, Catalan Collaborative Study Group for CJD
Eur J Neurol. 2004
PubMed ID: 15469448
Polymorphisms of the PRNP gene in Chinese populations and the identification of a novel insertion mutation.
Yu SL, Jin L, Sy MS, Mei FH, Kang SL, Sun GH, Tien P, Wang FS, Xiao GF
Eur J Hum Genet. 2004
PubMed ID: 15266305
Human Doppel and prion protein share common membrane microdomains and internalization pathways.
Massimino ML, Ballarin C, Bertoli A, Casonato S, Genovesi S, Negro A, Sorgato MC
Int J Biochem Cell Biol. 2004
PubMed ID: 15203115
Ionic strength and transition metals control PrPSc protease resistance and conversion-inducing activity.
Nishina K, Jenks S, Supattapone S
J Biol Chem. 2004
PubMed ID: 15262998
PrPSc binding antibodies are potent inhibitors of prion replication in cell lines.
Beringue V, Vilette D, Mallinson G, Archer F, Kaisar M, Tayebi M, Jackson GS, Clarke AR, Laude H, Collinge J, Hawke S
J Biol Chem. 2004
PubMed ID: 15133046
Identification of distinct N-terminal truncated forms of prion protein in different Creutzfeldt-Jakob disease subtypes.
Zanusso G, Farinazzo A, Prelli F, Fiorini M, Gelati M, Ferrari S, Righetti PG, Rizzuto N, Frangione B, Monaco S
J Biol Chem. 2004
PubMed ID: 15247220
Cre-loxP mediated control of PrP to study transmissible spongiform encephalopathy diseases.
Tuzi NL, Clarke AR, Bradford B, Aitchison L, Thomson V, Manson JC
Genesis. 2004
PubMed ID: 15354287
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S
Genome Res. 2004
PubMed ID: 15342556
PrP(C) association with lipid rafts in the early secretory pathway stabilizes its cellular conformation.
Sarnataro D, Campana V, Paladino S, Stornaiuolo M, Nitsch L, Zurzolo C
Mol Biol Cell. 2004
PubMed ID: 15229281
Cortical malformations are associated with a rare polymorphism of cellular prion protein.
Walz R, Castro RM, Landemberger MC, Velasco TR, Terra-Bustamante VC, Bastos AC, Bianchin M, Wichert-Ana L, Araújo D, Alexandre V, Santos AC, Machado HR, Carlotti CG, Brentani RR, Martins VR, Sakamoto AC
Neurology. 2004
PubMed ID: 15304595
GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice.
Barmada S, Piccardo P, Yamaguchi K, Ghetti B, Harris DA
Neurobiol Dis. 2004
PubMed ID: 15262264
Octapeptide repeat insertions in the prion protein gene and early onset dementia.
Croes EA, Theuns J, Houwing-Duistermaat JJ, Dermaut B, Sleegers K, Roks G, Van den Broeck M, van Harten B, van Swieten JC, Cruts M, Van Broeckhoven C, van Duijn CM
J Neurol Neurosurg Psychiatry. 2004
PubMed ID: 15258222
Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.
Maloney B, Ge YW, Greig N, Lahiri DK
FASEB J. 2004
PubMed ID: 15208260
Synthetic mammalian prions.
Legname G, Baskakov IV, Nguyen HO, Riesner D, Cohen FE, DeArmond SJ, Prusiner SB
Science. 2004
PubMed ID: 15286374
Hydration and packing effects on prion folding and beta-sheet conversion. High pressure spectroscopy and pressure perturbation calorimetry studies.
Cordeiro Y, Kraineva J, Ravindra R, Lima LM, Gomes MP, Foguel D, Winter R, Silva JL
J Biol Chem. 2004
PubMed ID: 15173173
Preferential Cu2+ coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein.
Jones CE, Abdelraheim SR, Brown DR, Viles JH
J Biol Chem. 2004
PubMed ID: 15145944
Prion protein codon 129 polymorphism and risk of Alzheimer disease.
Riemenschneider M, Klopp N, Xiang W, Wagenpfeil S, Vollmert C, Müller U, Förstl H, Illig T, Kretzschmar H, Kurz A
Neurology. 2004
PubMed ID: 15277640
Methionine 129 variant of human prion protein oligomerizes more rapidly than the valine 129 variant: implications for disease susceptibility to Creutzfeldt-Jakob disease.
Tahiri-Alaoui A, Gill AC, Disterer P, James W
J Biol Chem. 2004
PubMed ID: 15131108
Nonenzymatic glycation at the N terminus of pathogenic prion protein in transmissible spongiform encephalopathies.
Choi YG, Kim JI, Jeon YC, Park SJ, Choi EK, Rubenstein R, Kascsak RJ, Carp RI, Kim YS
J Biol Chem. 2004
PubMed ID: 15084583
Doppel-induced Purkinje cell death is stoichiometrically abrogated by prion protein.
Yamaguchi N, Sakaguchi S, Shigematsu K, Okimura N, Katamine S
Biochem Biophys Res Commun. 2004
PubMed ID: 15194501
Acute formation of protease-resistant prion protein does not always lead to persistent scrapie infection in vitro.
Vorberg I, Raines A, Priola SA
J Biol Chem. 2004
PubMed ID: 15133048
Cell surface expression of the prion protein in yeast does not alter copper utilization phenotypes.
Li A, Dong J, Harris DA
J Biol Chem. 2004
PubMed ID: 15090539
The residue 129 polymorphism in human prion protein does not confer susceptibility to Creutzfeldt-Jakob disease by altering the structure or global stability of PrPC.
Hosszu LL, Jackson GS, Trevitt CR, Jones S, Batchelor M, Bhelt D, Prodromidou K, Clarke AR, Waltho JP, Collinge J
J Biol Chem. 2004
PubMed ID: 15123682
Disease-associated prion protein elicits immunoglobulin M responses in vivo.
Tayebi M, Enever P, Sattar Z, Collinge J, Hawke S
Mol Med. 2004
PubMed ID: 15706401
Prion protein accumulation and neuroprotection in hypoxic brain damage.
McLennan NF, Brennan PM, McNeill A, Davies I, Fotheringham A, Rennison KA, Ritchie D, Brannan F, Head MW, Ironside JW, Williams A, Bell JE
Am J Pathol. 2004
PubMed ID: 15215178
Intrinsic resistance of oligodendrocytes to prion infection.
Prinz M, Montrasio F, Furukawa H, van der Haar ME, Schwarz P, Rülicke T, Giger OT, Häusler KG, Perez D, Glatzel M, Aguzzi A
J Neurosci. 2004
PubMed ID: 15229245
Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice.
Paisley D, Banks S, Selfridge J, McLennan NF, Ritchie AM, McEwan C, Irvine DS, Saunders PT, Manson JC, Melton DW
Am J Pathol. 2004
PubMed ID: 15161660
Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues.
Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA
Nat Biotechnol. 2004
PubMed ID: 15146195
Prion protein stimulates tissue-type plasminogen activator-mediated plasmin generation via a lysine-binding site on kringle 2.
Epple G, Schleuning WD, Kettelgerdes G, Kottgen E, Gessner R, Praus M
J Thromb Haemost. 2004
PubMed ID: 15140132
Subclinical bovine spongiform encephalopathy infection in transgenic mice expressing porcine prion protein.
Castilla J, Gutiérrez-Adán A, Brun A, Doyle D, Pintado B, Ramírez MA, Salguero FJ, Parra B, Segundo FD, Sánchez-Vizcaíno JM, Rogers M, Torres JM
J Neurosci. 2004
PubMed ID: 15163699
Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation.
Yadavalli R, Guttmann RP, Seward T, Centers AP, Williamson RA, Telling GC
J Biol Chem. 2004
PubMed ID: 15026410
Identification and characterization of a novel mouse prion gene allele.
Lloyd SE, Thompson SR, Beck JA, Linehan JM, Wadsworth JD, Brandner S, Collinge J, Fisher EM
Mamm Genome. 2004
PubMed ID: 15170227
Scrapie-like prion protein is translocated to the nuclei of infected cells independently of proteasome inhibition and interacts with chromatin.
Mangé A, Crozet C, Lehmann S, Béranger F
J Cell Sci. 2004
PubMed ID: 15126640
Polymorphisms in the prion protein gene and in the doppel gene increase susceptibility for Creutzfeldt-Jakob disease.
Croes EA, Alizadeh BZ, Bertoli-Avella AM, Rademaker T, Vergeer-Drop J, Dermaut B, Houwing-Duistermaat JJ, Wientjens DP, Hofman A, Van Broeckhoven C, van Duijn CM
Eur J Hum Genet. 2004
PubMed ID: 14970845
The effect of disease-associated mutations on the folding pathway of human prion protein.
Apetri AC, Surewicz K, Surewicz WK
J Biol Chem. 2004
PubMed ID: 14761942
Pathogenic human prion protein rescues PrP null phenotype in transgenic mice.
Asante EA, Li YG, Gowland I, Jefferys JG, Collinge J
Neurosci Lett. 2004
PubMed ID: 15082172
Hyperbaric oxygen enhances the expression of prion protein and heat shock protein 70 in a mouse neuroblastoma cell line.
Shyu WC, Lin SZ, Saeki K, Kubosaki A, Matsumoto Y, Onodera T, Chiang MF, Thajeb P, Li H
Cell Mol Neurobiol. 2004
PubMed ID: 15176439
Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions.
Genoud N, Behrens A, Miele G, Robay D, Heppner FL, Freigang S, Aguzzi A
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15007175
Cross-linking cellular prion protein triggers neuronal apoptosis in vivo.
Solforosi L, Criado JR, McGavern DB, Wirz S, Sánchez-Alavez M, Sugama S, DeGiorgio LA, Volpe BT, Wiseman E, Abalos G, Masliah E, Gilden D, Oldstone MB, Conti B, Williamson RA
Science. 2004
PubMed ID: 14752167
Different behavior toward bovine spongiform encephalopathy infection of bovine prion protein transgenic mice with one extra repeat octapeptide insert mutation.
Castilla J, Gutiérrez-Adán A, Brun A, Pintado B, Parra B, Ramírez MA, Salguero FJ, Díaz San Segundo F, Rábano A, Cano MJ, Torres JM
J Neurosci. 2004
PubMed ID: 14999066
Alpha- and beta- cleavages of the amino-terminus of the cellular prion protein.
Mangé A, Béranger F, Peoc'h K, Onodera T, Frobert Y, Lehmann S
Biol Cell. 2004
PubMed ID: 15050367
Both lysine-clusters of the NH2-terminal prion-protein fragment PrP23-110 are essential for t-PA mediated plasminogen activation.
Epple G, Langfeld K, Baier M, Holzhütter HG, Schleuning WD, Köttgen E, Gessner R, Praus M
Thromb Haemost. 2004
PubMed ID: 14983221
Autocatalytic conversion of recombinant prion proteins displays a species barrier.
Baskakov IV
J Biol Chem. 2004
PubMed ID: 14668351
The membrane domains occupied by glycosylphosphatidylinositol-anchored prion protein and Thy-1 differ in lipid composition.
Brügger B, Graham C, Leibrecht I, Mombelli E, Jen A, Wieland F, Morris R
J Biol Chem. 2004
PubMed ID: 14660659
The C-terminal globular domain of the prion protein is necessary and sufficient for import into the endoplasmic reticulum.
Heske J, Heller U, Winklhofer KF, Tatzelt J
J Biol Chem. 2004
PubMed ID: 14645231
Mutant PrPSc conformers induced by a synthetic peptide and several prion strains.
Tremblay P, Ball HL, Kaneko K, Groth D, Hegde RS, Cohen FE, DeArmond SJ, Prusiner SB, Safar JG
J Virol. 2004
PubMed ID: 14747574
Polymorphisms within the prion (PrP) and prion-like protein (Doppel) genes in AD.
Golanska E, Hulas-Bigoszewska K, Rutkiewicz E, Styczynska M, Peplonska B, Barcikowska M, Bratosiewicz-Wasik J, Liberski PP
Neurology. 2004
PubMed ID: 14745079
A mouse to remember.
Weissmann C, Büeler H
Cell. 2004
PubMed ID: 15055597
Prion protein suppresses perturbation of cellular copper homeostasis under oxidative conditions.
Sakudo A, Lee DC, Yoshimura E, Nagasaka S, Nitta K, Saeki K, Matsumoto Y, Lehmann S, Itohara S, Sakaguchi S, Onodera T
Biochem Biophys Res Commun. 2004
PubMed ID: 14706620
Immunoseparation of Prion protein-enriched domains from other detergent-resistant membrane fractions, isolated from neuronal cells.
Botto L, Masserini M, Cassetti A, Palestini P
FEBS Lett. 2004
PubMed ID: 14741357
Microtubules-associated intracellular localization of the NH2-terminal cellular prion protein fragment.
Hachiya NS, Watanabe K, Sakasegawa Y, Kaneko K
Biochem Biophys Res Commun. 2004
PubMed ID: 14697265
Prion protein prevents human breast carcinoma cell line from tumor necrosis factor alpha-induced cell death.
Diarra-Mehrpour M, Arrabal S, Jalil A, Pinson X, Gaudin C, Piétu G, Pitaval A, Ripoche H, Eloit M, Dormont D, Chouaib S
Cancer Res. 2004
PubMed ID: 14744790
The cellular prion protein PrPc is expressed in human enterocytes in cell-cell junctional domains.
Morel E, Fouquet S, Chateau D, Yvernault L, Frobert Y, Pincon-Raymond M, Chambaz J, Pillot T, Rousset M
J Biol Chem. 2004
PubMed ID: 14576159
Primary cultured neurons devoid of cellular prion display lower responsiveness to staurosporine through the control of p53 at both transcriptional and post-transcriptional levels.
Paitel E, Sunyach C, Alves da Costa C, Bourdon JC, Vincent B, Checler F
J Biol Chem. 2004
PubMed ID: 14570892
Polymorphisms of the prion protein gene (PRNP) in a Korean population.
Jeong BH, Nam JH, Lee YJ, Lee KH, Jang MK, Carp RI, Lee HD, Ju YR, Ahn Jo S, Park KY, Kim YS
J Hum Genet. 2004
PubMed ID: 15148589
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Novel heparan mimetics potently inhibit the scrapie prion protein and its endocytosis.
Schonberger O, Horonchik L, Gabizon R, Papy-Garcia D, Barritault D, Taraboulos A
Biochem Biophys Res Commun. 2003
PubMed ID: 14637161
Folding intermediates of the prion protein stabilized by hydrostatic pressure and low temperature.
Martins SM, Chapeaurouge A, Ferreira ST
J Biol Chem. 2003
PubMed ID: 14525996
CD and NMR studies of prion protein (PrP) helix 1. Novel implications for its role in the PrPC-->PrPSc conversion process.
Ziegler J, Sticht H, Marx UC, Müller W, Rösch P, Schwarzinger S
J Biol Chem. 2003
PubMed ID: 12952977
EAAT4 mRNA expression is preserved in the cerebellum of prion protein-deficient mice.
Yukitake M, Satoh J, Katamine S, Kuroda Y
Neurosci Lett. 2003
PubMed ID: 14625012
NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril formation of prion protein fragment 106-126.
Kuwata K, Matumoto T, Cheng H, Nagayama K, James TL, Roder H
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14657385
Humanized knock-in mice expressing chimeric prion protein showed varied susceptibility to different human prions.
Taguchi Y, Mohri S, Ironside JW, Muramoto T, Kitamoto T
Am J Pathol. 2003
PubMed ID: 14633630
Amino terminal interaction in the prion protein identified using fusion to green fluorescent protein.
Yao Y, Ren J, Jones IM
J Neurochem. 2003
PubMed ID: 14622086
The octapeptide repeats in mammalian prion protein constitute a pH-dependent folding and aggregation site.
Zahn R
J Mol Biol. 2003
PubMed ID: 14623188
Structural properties of Gerstmann-Straussler-Scheinker disease amyloid protein.
Salmona M, Morbin M, Massignan T, Colombo L, Mazzoleni G, Capobianco R, Diomede L, Thaler F, Mollica L, Musco G, Kourie JJ, Bugiani O, Sharma D, Inouye H, Kirschner DA, Forloni G, Tagliavini F
J Biol Chem. 2003
PubMed ID: 12970341
Mutational analysis of topological determinants in prion protein (PrP) and measurement of transmembrane and cytosolic PrP during prion infection.
Stewart RS, Harris DA
J Biol Chem. 2003
PubMed ID: 12933795
Surgical outcome in mesial temporal sclerosis correlates with prion protein gene variant.
Walz R, Castro RM, Velasco TR, Alexandre V, Lopes MH, Leite JP, Santos AC, Assirati JA, Wichert-Ana L, Terra-Bustamante VC, Bianchin MM, Maciag PC, Ribeiro KB, Guarnieri R, Araújo D, Cabalero O, Moura R, Salim AC, Kindlmann K, Landemberger MC, Marques W, Fernandes RM, Serafini LN, Machado HR, Carlotti CG, Brentani RR, Sakamoto AC, Martins VR
Neurology. 2003
PubMed ID: 14610121
NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells.
Schneider B, Mutel V, Pietri M, Ermonval M, Mouillet-Richard S, Kellermann O
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14597699
The normal population distribution of PRNP codon 129 polymorphism.
Nurmi MH, Bishop M, Strain L, Brett F, McGuigan C, Hutchison M, Farrell M, Tilvis R, Erkkilä S, Simell O, Knight R, Haltia M
Acta Neurol Scand. 2003
PubMed ID: 14616310
M129V variation in the prion protein may influence cognitive performance.
Rujescu D, Hartmann AM, Gonnermann C, Möller HJ, Giegling I
Mol Psychiatry. 2003
PubMed ID: 14593432
Transmission of murine scrapie to P101L transgenic mice.
Barron RM, Thomson V, King D, Shaw J, Melton DW, Manson JC
J Gen Virol. 2003
PubMed ID: 14573822
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.
Mallucci G, Dickinson A, Linehan J, Klöhn PC, Brandner S, Collinge J
Science. 2003
PubMed ID: 14593181
Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons.
Roucou X, Guo Q, Zhang Y, Goodyer CG, LeBlanc AC
J Biol Chem. 2003
PubMed ID: 12917444
Identification of novel proteinase K-resistant C-terminal fragments of PrP in Creutzfeldt-Jakob disease.
Zou WQ, Capellari S, Parchi P, Sy MS, Gambetti P, Chen SG
J Biol Chem. 2003
PubMed ID: 12917418
Nucleation-dependent conformational conversion of the Y145Stop variant of human prion protein: structural clues for prion propagation.
Kundu B, Maiti NR, Jones EM, Surewicz KA, Vanik DL, Surewicz WK
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14519851
Cellular heparan sulfate participates in the metabolism of prions.
Ben-Zaken O, Tzaban S, Tal Y, Horonchik L, Esko JD, Vlodavsky I, Taraboulos A
J Biol Chem. 2003
PubMed ID: 12871949
Prion protein expression modulates neuronal copper content.
Brown DR
J Neurochem. 2003
PubMed ID: 14511115
Post-translational import of the prion protein into the endoplasmic reticulum interferes with cell viability: a critical role for the putative transmembrane domain.
Heller U, Winklhofer KF, Heske J, Reintjes A, Tatzelt J
J Biol Chem. 2003
PubMed ID: 12853456
Small, highly structured RNAs participate in the conversion of human recombinant PrP(Sen) to PrP(Res) in vitro.
Adler V, Zeiler B, Kryukov V, Kascsak R, Rubenstein R, Grossman A
J Mol Biol. 2003
PubMed ID: 12946346
Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes.
Rouvinski A, Gahali-Sass I, Stav I, Metzer E, Atlan H, Taraboulos A
Biochem Biophys Res Commun. 2003
PubMed ID: 12927782
No superoxide dismutase activity of cellular prion protein in vivo.
Hutter G, Heppner FL, Aguzzi A
Biol Chem. 2003
PubMed ID: 14515989
Unexpected high testis-specific transcriptional activity of the cyclin T1 promoter in transgenic mice.
Mata X, Besnard N, Le Roux K, Tilly G, Andréoletti O, Hudrisier M, Costa Da Silva J, Laude H, Vilotte JL
FEBS Lett. 2003
PubMed ID: 12914944
Expression of normal cellular prion protein (PrP(c)) on T lymphocytes and the effect of copper ion: Analysis by wild-type and prion protein gene-deficient mice.
Kubosaki A, Nishimura-Nasu Y, Nishimura T, Yusa S, Sakudo A, Saeki K, Matsumoto Y, Itohara S, Onodera T
Biochem Biophys Res Commun. 2003
PubMed ID: 12878182
Cytosolic prion protein in neurons.
Mironov A, Latawiec D, Wille H, Bouzamondo-Bernstein E, Legname G, Williamson RA, Burton D, DeArmond SJ, Prusiner SB, Peters PJ
J Neurosci. 2003
PubMed ID: 12904479
Heterogeneity and regulation of cellular prion protein glycoforms in neuronal cell lines.
Monnet C, Marthiens V, Enslen H, Frobert Y, Sobel A, Mège RM
Eur J Neurosci. 2003
PubMed ID: 12911750
Deletion of N-terminal residues 23-88 from prion protein (PrP) abrogates the potential to rescue PrP-deficient mice from PrP-like protein/doppel-induced Neurodegeneration.
Atarashi R, Nishida N, Shigematsu K, Goto S, Kondo T, Sakaguchi S, Katamine S
J Biol Chem. 2003
PubMed ID: 12759361
Cellular prion protein ablation impairs behavior as a function of age.
Coitinho AS, Roesler R, Martins VR, Brentani RR, Izquierdo I
Neuroreport. 2003
PubMed ID: 12876477
Distribution of codon 129 genotype in human growth hormone-treated CJD patients in France and the UK.
Brandel JP, Preece M, Brown P, Croes E, Laplanche JL, Agid Y, Will R, Alpérovitch A
Lancet. 2003
PubMed ID: 12867116
A prion protein epitope selective for the pathologically misfolded conformation.
Paramithiotis E, Pinard M, Lawton T, LaBoissiere S, Leathers VL, Zou WQ, Estey LA, Lamontagne J, Lehto MT, Kondejewski LH, Francoeur GP, Papadopoulos M, Haghighat A, Spatz SJ, Head M, Will R, Ironside J, O'Rourke K, Tonelli Q, Ledebur HC, Chakrabartty A, Cashman NR
Nat Med. 2003
PubMed ID: 12778138
Neuropathological features of a case with schizophrenia and prion protein gene P102L mutation before onset of Gerstmann-Sträussler-Scheinker disease.
Sasaki K, Doh-ura K, Furuta A, Nakashima S, Morisada Y, Tateishi J, Iwaki T
Acta Neuropathol. 2003
PubMed ID: 12682740
Polymorphism of the codon 129 of the prion protein (PrP) gene and neuropathology of cerebral ageing.
Berr C, Helbecque N, Sazdovitch V, Mohr M, Amant C, Amouyel P, Alpérovitch A, Hauw JJ
Acta Neuropathol. 2003
PubMed ID: 12679875
The interplay of glycosylation and disulfide formation influences fibrillization in a prion protein fragment.
Bosques CJ, Imperiali B
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12805563
Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia.
Flechsig E, Hegyi I, Leimeroth R, Zuniga A, Rossi D, Cozzio A, Schwarz P, Rülicke T, Götz J, Aguzzi A, Weissmann C
EMBO J. 2003
PubMed ID: 12805223
Immunologically induced, complement-dependent up-regulation of the prion protein in the mouse spleen: follicular dendritic cells versus capsule and trabeculae.
Lötscher M, Recher M, Hunziker L, Klein MA
J Immunol. 2003
PubMed ID: 12794132
Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation.
Drisaldi B, Stewart RS, Adles C, Stewart LR, Quaglio E, Biasini E, Fioriti L, Chiesa R, Harris DA
J Biol Chem. 2003
PubMed ID: 12663673
The 129 codon polymorphism of the prion protein gene influences earlier cognitive performance in Down syndrome subjects.
Del Bo R, Comi GP, Giorda R, Crimi M, Locatelli F, Martinelli-Boneschi F, Pozzoli U, Castelli E, Bresolin N, Scarlato G
J Neurol. 2003
PubMed ID: 12796830
Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice.
Curtis J, Errington M, Bliss T, Voss K, MacLeod N
Neurobiol Dis. 2003
PubMed ID: 12758067
Stimulation of plasminogen activation by recombinant cellular prion protein is conserved in the NH2-terminal fragment PrP23-110.
Praus M, Kettelgerdes G, Baier M, Holzhütter HG, Jungblut PR, Maissen M, Epple G, Schleuning WD, Köttgen E, Aguzzi A, Gessner R
Thromb Haemost. 2003
PubMed ID: 12719777
The human prion octarepeat fragment prevents and reverses the inhibitory action of copper in the P2X4 receptor without modifying the zinc action.
Lorca RA, Chacón M, Barría MI, Inestrosa NC, Huidobro-Toro JP
J Neurochem. 2003
PubMed ID: 12694397
Sphingosine kinase-dependent migration of immature dendritic cells in response to neurotoxic prion protein fragment.
Kaneider NC, Kaser A, Dunzendorfer S, Tilg H, Wiedermann CJ
J Virol. 2003
PubMed ID: 12692258
Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics.
Mead S, Stumpf MP, Whitfield J, Beck JA, Poulter M, Campbell T, Uphill JB, Goldstein D, Alpers M, Fisher EM, Collinge J
Science. 2003
PubMed ID: 12690204
Determinants of the in vivo folding of the prion protein. A bipartite function of helix 1 in folding and aggregation.
Winklhofer KF, Heske J, Heller U, Reintjes A, Muranyi W, Moarefi I, Tatzelt J
J Biol Chem. 2003
PubMed ID: 12556465
Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene.
Korth C, Kaneko K, Groth D, Heye N, Telling G, Mastrianni J, Parchi P, Gambetti P, Will R, Ironside J, Heinrich C, Tremblay P, DeArmond SJ, Prusiner SB
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12684540
Soluble dimeric prion protein binds PrP(Sc) in vivo and antagonizes prion disease.
Meier P, Genoud N, Prinz M, Maissen M, Rülicke T, Zurbriggen A, Raeber AJ, Aguzzi A
Cell. 2003
PubMed ID: 12679034
On the same cell type GPI-anchored normal cellular prion and DAF protein exhibit different biological properties.
Li R, Liu T, Yoshihiro F, Tary-Lehmann M, Obrenovich M, Kuekrek H, Kang SC, Pan T, Wong BS, Medof ME, Sy MS
Biochem Biophys Res Commun. 2003
PubMed ID: 12659837
Early detection of PrPres in BSE-infected bovine PrP transgenic mice.
Castilla J, Gutiérrez Adán A, Brun A, Pintado B, Ramírez MA, Parra B, Doyle D, Rogers M, Salguero FJ, Sánchez C, Sánchez-Vizcaíno JM, Torres JM
Arch Virol. 2003
PubMed ID: 12664293
Cellular prion protein sensitizes neurons to apoptotic stimuli through Mdm2-regulated and p53-dependent caspase 3-like activation.
Paitel E, Fahraeus R, Checler F
J Biol Chem. 2003
PubMed ID: 12529324
Expression of prion protein increases cellular copper binding and antioxidant enzyme activities but not copper delivery.
Rachidi W, Vilette D, Guiraud P, Arlotto M, Riondel J, Laude H, Lehmann S, Favier A
J Biol Chem. 2003
PubMed ID: 12500977
Monoclonal antibodies inhibit prion replication and delay the development of prion disease.
White AR, Enever P, Tayebi M, Mushens R, Linehan J, Brandner S, Anstee D, Collinge J, Hawke S
Nature. 2003
PubMed ID: 12621436
Susceptibility of transgenic mice expressing chimeric sheep, bovine and human PrP genes to sheep scrapie.
Gombojav A, Shimauchi I, Horiuchi M, Ishiguro N, Shinagawa M, Kitamoto T, Miyoshi I, Mohri S, Takata M
J Vet Med Sci. 2003
PubMed ID: 12679564
PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease.
Dermaut B, Croes EA, Rademakers R, Van den Broeck M, Cruts M, Hofman A, van Duijn CM, Van Broeckhoven C
Ann Neurol. 2003
PubMed ID: 12601712
NMR structure of a variant human prion protein with two disulfide bridges.
Zahn R, Güntert P, von Schroetter C, Wüthrich K
J Mol Biol. 2003
PubMed ID: 12547204
Essential role of the prion protein N terminus in subcellular trafficking and half-life of cellular prion protein.
Nunziante M, Gilch S, Schätzl HM
J Biol Chem. 2003
PubMed ID: 12431994
Aggresome formation by mutant prion proteins: the unfolding role of proteasomes in familial prion disorders.
Mishra RS, Bose S, Gu Y, Li R, Singh N
J Alzheimers Dis. 2003
PubMed ID: 12590162
Prions prevent brain damage after experimental brain injury: a preliminary report.
Hoshino S, Inoue K, Yokoyama T, Kobayashi S, Asakura T, Teramoto A, Itohara S
Acta Neurochir Suppl. 2003
PubMed ID: 14753456
CD34+ cells from paroxysmal nocturnal hemoglobinuria (PNH) patients are deficient in surface expression of cellular prion protein (PrPc).
Risitano AM, Holada K, Chen G, Simak J, Vostal JG, Young NS, Maciejewski JP
Exp Hematol. 2003
PubMed ID: 12543108
Molecular evolution of the mammalian prion protein.
van Rheede T, Smolenaars MM, Madsen O, de Jong WW
Mol Biol Evol. 2003
PubMed ID: 12519913
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Prion and doppel proteins bind to granule cells of the cerebellum.
Legname G, Nelken P, Guan Z, Kanyo ZF, DeArmond SJ, Prusiner SB
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12446843
Intercellular transfer of the cellular prion protein.
Liu T, Li R, Pan T, Liu D, Petersen RB, Wong BS, Gambetti P, Sy MS
J Biol Chem. 2002
PubMed ID: 12359724
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
A cluster of familial Creutzfeldt-Jakob disease mutations recapitulate conserved residues in Doppel: a case of molecular mimicry?
Mastrangelo P, Serpell L, Dafforn T, Lesk A, Fraser P, Westaway D
FEBS Lett. 2002
PubMed ID: 12459456
BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein.
Asante EA, Linehan JM, Desbruslais M, Joiner S, Gowland I, Wood AL, Welch J, Hill AF, Lloyd SE, Wadsworth JD, Collinge J
EMBO J. 2002
PubMed ID: 12456643
Structural features of prions explored by sequence analysis. II. A PrP(Sc) model.
Mornon JP, Prat K, Dupuis F, Boisset N, Callebaut I
Cell Mol Life Sci. 2002
PubMed ID: 12568340
Genomic characterization of the human prion protein (PrP) gene locus.
Makrinou E, Collinge J, Antoniou M
Mamm Genome. 2002
PubMed ID: 12514748
Effect of the prion 129 polymorphism on nocturnal sleep and insomnia complaints: a population-based study.
Pedrazzoli M, Ling L, Young TB, Finn L, Tufik S, Mignot E
J Sleep Res. 2002
PubMed ID: 12464104
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol.
Ma J, Wollmann R, Lindquist S
Science. 2002
PubMed ID: 12386337
Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol.
Ma J, Lindquist S
Science. 2002
PubMed ID: 12386336
Cell membrane translocation of the N-terminal (1-28) part of the prion protein.
Lundberg P, Magzoub M, Lindberg M, Hällbrink M, Jarvet J, Eriksson LE, Langel U, Gräslund A
Biochem Biophys Res Commun. 2002
PubMed ID: 12435392
Kinetic intermediate in the folding of human prion protein.
Apetri AC, Surewicz WK
J Biol Chem. 2002
PubMed ID: 12356762
Decreased hyperlocomotion induced by MK-801, but not amphetamine and caffeine in mice lacking cellular prion protein (PrP(C)).
Coitinho AS, Dietrich MO, Hoffmann A, Dall'Igna OP, Souza DO, Martins VR, Brentani RR, Izquierdo I, Lara DR
Brain Res Mol Brain Res. 2002
PubMed ID: 12425947
Cell-surface prion protein interacts with glycosaminoglycans.
Pan T, Wong BS, Liu T, Li R, Petersen RB, Sy MS
Biochem J. 2002
PubMed ID: 12186633
Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form.
Zou WQ, Cashman NR
J Biol Chem. 2002
PubMed ID: 12161431
Polymorphism at codon 174 of the prion-like protein gene is not associated with sporadic Alzheimer's disease.
Infante J, Llorca J, Rodero L, Palacio E, Berciano J, Combarros O
Neurosci Lett. 2002
PubMed ID: 12399017
Sequence gaps join mice and men: phylogenetic evidence from deletions in two proteins.
Poux C, van Rheede T, Madsen O, de Jong WW
Mol Biol Evol. 2002
PubMed ID: 12411613
PrPC is sorted to the basolateral membrane of epithelial cells independently of its association with rafts.
Sarnataro D, Paladino S, Campana V, Grassi J, Nitsch L, Zurzolo C
Traffic. 2002
PubMed ID: 12383347
Recombinant human prion protein mutants huPrP D178N/M129 (FFI) and huPrP+9OR (fCJD) reveal proteinase K resistance.
Gauczynski S, Krasemann S, Bodemer W, Weiss S
J Cell Sci. 2002
PubMed ID: 12356908
Doppel and PrP(C) do not share the same membrane microenvironment.
Shaked Y, Hijazi N, Gabizon R
FEBS Lett. 2002
PubMed ID: 12387871
Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes.
Tzaban S, Friedlander G, Schonberger O, Horonchik L, Yedidia Y, Shaked G, Gabizon R, Taraboulos A
Biochemistry. 2002
PubMed ID: 12379130
Stimulation of PrP(C) retrograde transport toward the endoplasmic reticulum increases accumulation of PrP(Sc) in prion-infected cells.
Béranger F, Mangé A, Goud B, Lehmann S
J Biol Chem. 2002
PubMed ID: 12163492
Identification of genetic loci affecting mouse-adapted bovine spongiform encephalopathy incubation time in mice.
Lloyd SE, Uphill JB, Targonski PV, Fisher EM, Collinge J
Neurogenetics. 2002
PubMed ID: 12481985
Dominant-negative inhibition of prion replication in transgenic mice.
Perrier V, Kaneko K, Safar J, Vergara J, Tremblay P, DeArmond SJ, Cohen FE, Prusiner SB, Wallace AC
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12271119
Changes in the glycosylation pattern of prion protein in murine scrapie. Implications for the mechanism of neurodegeneration in prion diseases.
Russelakis-Carneiro M, Saborio GP, Anderes L, Soto C
J Biol Chem. 2002
PubMed ID: 12130636
Unusual property of prion protein unfolding in neutral salt solution.
Nandi PK, Leclerc E, Marc D
Biochemistry. 2002
PubMed ID: 12206674
DNA-induced partial unfolding of prion protein leads to its polymerisation to amyloid.
Nandi PK, Leclerc E, Nicole JC, Takahashi M
J Mol Biol. 2002
PubMed ID: 12215421
Endocytic intermediates involved with the intracellular trafficking of a fluorescent cellular prion protein.
Magalhães AC, Silva JA, Lee KS, Martins VR, Prado VF, Ferguson SS, Gomez MV, Brentani RR, Prado MA
J Biol Chem. 2002
PubMed ID: 12070160
Spontaneous mutations in the prion protein gene causing transmissible spongiform encephalopathy.
Dagvadorj A, Petersen RB, Lee HS, Cervenakova L, Shatunov A, Budka H, Brown P, Gambetti P, Goldfarb LG
Ann Neurol. 2002
PubMed ID: 12205650
Molecular modulation of expression of prion protein by heat shock.
Shyu WC, Harn HJ, Saeki K, Kubosaki A, Matsumoto Y, Onodera T, Chen CJ, Hsu YD, Chiang YH
Mol Neurobiol. 2002
PubMed ID: 12392052
Properties of the cellular prion protein expressed in Xenopus oocytes.
Connolly JG, Tate RJ, McLennan NF, Brown D, Telling GC, Fraser J, Head MW
Neuroreport. 2002
PubMed ID: 12151775
Cellular prion protein transduces neuroprotective signals.
Chiarini LB, Freitas AR, Zanata SM, Brentani RR, Martins VR, Linden R
EMBO J. 2002
PubMed ID: 12093733
Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection.
Zanata SM, Lopes MH, Mercadante AF, Hajj GN, Chiarini LB, Nomizo R, Freitas AR, Cabral AL, Lee KS, Juliano MA, de Oliveira E, Jachieri SG, Burlingame A, Huang L, Linden R, Brentani RR, Martins VR
EMBO J. 2002
PubMed ID: 12093732
The binding of prion proteins to serum components is affected by detergent extraction conditions.
Shaked Y, Engelstein R, Gabizon R
J Neurochem. 2002
PubMed ID: 12091459
Activated platelets of patients with paroxysmal nocturnal hemoglobinuria express cellular prion protein.
Holada K, Simak J, Risitano AM, Maciejewski J, Young NS, Vostal JG
Blood. 2002
PubMed ID: 12070046
Pathway complexity of prion protein assembly into amyloid.
Baskakov IV, Legname G, Baldwin MA, Prusiner SB, Cohen FE
J Biol Chem. 2002
PubMed ID: 11912192
Identification of the heparan sulfate binding sites in the cellular prion protein.
Warner RG, Hundt C, Weiss S, Turnbull JE
J Biol Chem. 2002
PubMed ID: 11882649
Folding and intrinsic stability of deletion variants of PrP(121-231), the folded C-terminal domain of the prion protein.
Eberl H, Glockshuber R
Biophys Chem. 2002
PubMed ID: 12034448
Cloning and sequencing of quail and pigeon prion genes.
Zhang L, Li N, Wang QG, Fan BL, Meng QY, Wu CX
Anim Biotechnol. 2002
PubMed ID: 12212939
Comparative analysis of normal prion protein expression on human, rodent, and ruminant blood cells by using a panel of prion antibodies.
Barclay GR, Houston EF, Halliday SI, Farquhar CF, Turner ML
Transfusion. 2002
PubMed ID: 12084159
All-trans retinoic acid down-regulates prion protein expression independently of granulocyte maturation.
Rybner C, Hillion J, Sahraoui T, Lanotte M, Botti J
Leukemia. 2002
PubMed ID: 11986958
Respiratory function in mice lacking or overexpressing the prion protein.
Boudinot E, Tremblay P, Champagnat J, Foutz AS
Neurosci Lett. 2002
PubMed ID: 11950500
PRNP contains both intronic and upstream regulatory regions that may influence susceptibility to Creutzfeldt-Jakob Disease.
McCormack JE, Baybutt HN, Everington D, Will RG, Ironside JW, Manson JC
Gene. 2002
PubMed ID: 12034503
Molecular features of the copper binding sites in the octarepeat domain of the prion protein.
Burns CS, Aronoff-Spencer E, Dunham CM, Lario P, Avdievich NI, Antholine WE, Olmstead MM, Vrielink A, Gerfen GJ, Peisach J, Scott WG, Millhauser GL
Biochemistry. 2002
PubMed ID: 11900542
Prions in skeletal muscle.
Bosque PJ, Ryou C, Telling G, Peretz D, Legname G, DeArmond SJ, Prusiner SB
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11904434
Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases.
Lorenz H, Windl O, Kretzschmar HA
J Biol Chem. 2002
PubMed ID: 11756421
Cellular prion protein is expressed on endothelial cells and is released during apoptosis on membrane microparticles found in human plasma.
Simák J, Holada K, D'Agnillo F, Janota J, Vostal JG
Transfusion. 2002
PubMed ID: 11961239
Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes.
Baron GS, Wehrly K, Dorward DW, Chesebro B, Caughey B
EMBO J. 2002
PubMed ID: 11867531
Expression of doppel in the CNS of mice does not modulate transmissible spongiform encephalopathy disease.
Tuzi NL, Gall E, Melton D, Manson JC
J Gen Virol. 2002
PubMed ID: 11842265
Ablation of cellular prion protein expression affects mitochondrial numbers and morphology.
Miele G, Jeffrey M, Turnbull D, Manson J, Clinton M
Biochem Biophys Res Commun. 2002
PubMed ID: 11846415
Regulation of the cellular prion protein gene expression depends on chromatin conformation.
Cabral AL, Lee KS, Martins VR
J Biol Chem. 2002
PubMed ID: 11739375
Loss of prion protein in a transgenic model of amyotrophic lateral sclerosis.
Dupuis L, Mbebi C, Gonzalez de Aguilar JL, Rene F, Muller A, de Tapia M, Loeffler JP
Mol Cell Neurosci. 2002
PubMed ID: 11860274
Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration.
Mallucci GR, Ratté S, Asante EA, Linehan J, Gowland I, Jefferys JG, Collinge J
EMBO J. 2002
PubMed ID: 11823413
Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells.
Prinz M, Montrasio F, Klein MA, Schwarz P, Priller J, Odermatt B, Pfeffer K, Aguzzi A
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11792852
Sleep deprivation in prion protein deficient mice sleep deprivation in prion protein deficient mice and control mice: genotype dependent regional rebound.
Huber R, Deboer T, Tobler I
Neuroreport. 2002
PubMed ID: 11924867
Lack of prion protein expression results in a neuronal phenotype sensitive to stress.
Brown DR, Nicholas RS, Canevari L
J Neurosci Res. 2002
PubMed ID: 11782965
[The prion protein]
Lehmann S
J Soc Biol. 2002
PubMed ID: 12645301
Rapid typing of the codon 129 polymorphism of the human prion protein gene by combined real-time PCR and melting curve analysis.
Schalasta G, Roth B, Enders G
Clin Lab. 2002
PubMed ID: 11833672
The cellular prion protein: a new partner of the lectin CBP70 in the nucleus of NB4 human promyelocytic leukemia cells.
Rybner C, Finel-Szermanski S, Felin M, Sahraoui T, Rousseau C, Fournier JG, Sève AP, Botti J
J Cell Biochem. 2002
PubMed ID: 11787070
The DNA sequence and comparative analysis of human chromosome 20.
Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J
Nature. 2001
PubMed ID: 11780052
Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation.
Ma J, Lindquist S
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11742063
Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein.
Schmitt-Ulms G, Legname G, Baldwin MA, Ball HL, Bradon N, Bosque PJ, Crossin KL, Edelman GM, DeArmond SJ, Cohen FE, Prusiner SB
J Mol Biol. 2001
PubMed ID: 11743735
Distribution of the M129V polymorphism of the prion protein gene in a Turkish population suggests a high risk for Creutzfeldt-Jakob disease.
Erginel-Unaltuna N, Peoc'h K, Komurcu E, Acuner TT, Issever H, Laplanche JL
Eur J Hum Genet. 2001
PubMed ID: 11840201
Sporadic--but not variant--Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP exon 1.
Mead S, Mahal SP, Beck J, Campbell T, Farrall M, Fisher E, Collinge J
Am J Hum Genet. 2001
PubMed ID: 11704923
Huntington disease phenocopy is a familial prion disease.
Moore RC, Xiang F, Monaghan J, Han D, Zhang Z, Edström L, Anvret M, Prusiner SB
Am J Hum Genet. 2001
PubMed ID: 11593450
PrPC directly interacts with proteins involved in signaling pathways.
Spielhaupter C, Schätzl HM
J Biol Chem. 2001
PubMed ID: 11571277
Chaperonin-mediated de novo generation of prion protein aggregates.
Stöckel J, Hartl FU
J Mol Biol. 2001
PubMed ID: 11697909
Influence of the prion protein and the apolipoprotein E genotype on the Creutzfeldt-Jakob Disease phenotype.
Van Everbroeck B, Croes EA, Pals P, Dermaut B, Jansen G, van Duijn CM, Cruts M, Van Broeckhoven C, Martin JJ, Cras P
Neurosci Lett. 2001
PubMed ID: 11684342
Species differences in the blood content of the normal cellular isoform of prion protein, PrP(c), measured by time-resolved fluoroimmunoassay.
MacGregor IR, Drummond O
Vox Sang. 2001
PubMed ID: 11903999
A new PRNP mutation (G131V) associated with Gerstmann-Sträussler-Scheinker disease.
Panegyres PK, Toufexis K, Kakulas BA, Cernevakova L, Brown P, Ghetti B, Piccardo P, Dlouhy SR
Arch Neurol. 2001
PubMed ID: 11709001
Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies.
Heppner FL, Musahl C, Arrighi I, Klein MA, Rülicke T, Oesch B, Zinkernagel RM, Kalinke U, Aguzzi A
Science. 2001
PubMed ID: 11546838
Role of the helix capping in the stability of the mouse prion (180-213) segment: investigation through molecular dynamics simulations.
Iovino M, Falconi M, Petruzzelli R, Desideri A
J Biomol Struct Dyn. 2001
PubMed ID: 11697729
Changing a single amino acid in the N-terminus of murine PrP alters TSE incubation time across three species barriers.
Barron RM, Thomson V, Jamieson E, Melton DW, Ironside J, Will R, Manson JC
EMBO J. 2001
PubMed ID: 11566872
All or none fibrillogenesis of a prion peptide.
Zou WQ, Yang DS, Fraser PE, Cashman NR, Chakrabartty A
Eur J Biochem. 2001
PubMed ID: 11559357
Crystal structure of the human prion protein reveals a mechanism for oligomerization.
Knaus KJ, Morillas M, Swietnicki W, Malone M, Surewicz WK, Yee VC
Nat Struct Biol. 2001
PubMed ID: 11524679
Combinatorial control of prion protein biogenesis by the signal sequence and transmembrane domain.
Kim SJ, Rahbar R, Hegde RS
J Biol Chem. 2001
PubMed ID: 11359769
Plasminogen binds to disease-associated prion protein of multiple species.
Maissen M, Roeckl C, Glatzel M, Goldmann W, Aguzzi A
Lancet. 2001
PubMed ID: 11438139
Efficient transmission of two different sheep scrapie isolates in transgenic mice expressing the ovine PrP gene.
Crozet C, Flamant F, Bencsik A, Aubert D, Samarut J, Baron T
J Virol. 2001
PubMed ID: 11333913
The prion protein has RNA binding and chaperoning properties characteristic of nucleocapsid protein NCP7 of HIV-1.
Gabus C, Derrington E, Leblanc P, Chnaiderman J, Dormont D, Swietnicki W, Morillas M, Surewicz WK, Marc D, Nandi P, Darlix JL
J Biol Chem. 2001
PubMed ID: 11278562
Identification of multiple quantitative trait loci linked to prion disease incubation period in mice.
Lloyd SE, Onwuazor ON, Beck JA, Mallinson G, Farrall M, Targonski P, Collinge J, Fisher EM
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11353827
Imbalance of antioxidant defense in mice lacking cellular prion protein.
Klamt F, Dal-Pizzol F, Conte da Frota ML, Walz R, Andrades ME, da Silva EG, Brentani RR, Izquierdo I, Fonseca Moreira JC
Free Radic Biol Med. 2001
PubMed ID: 11369504
Copper converts the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform.
Quaglio E, Chiesa R, Harris DA
J Biol Chem. 2001
PubMed ID: 11278539
In vivo conversion of cellular prion protein to pathogenic isoforms, as monitored by conformation-specific antibodies.
Yokoyama T, Kimura KM, Ushiki Y, Yamada S, Morooka A, Nakashiba T, Sassa T, Itohara S
J Biol Chem. 2001
PubMed ID: 11152682
Induction of HO-1 and NOS in doppel-expressing mice devoid of PrP: implications for doppel function.
Wong BS, Liu T, Paisley D, Li R, Pan T, Chen SG, Perry G, Petersen RB, Smith MA, Melton DW, Gambetti P, Brown DR, Sy MS
Mol Cell Neurosci. 2001
PubMed ID: 11312611
Prion protein affects Ca2+-activated K+ currents in cerebellar purkinje cells.
Herms JW, Tings T, Dunker S, Kretzschmar HA
Neurobiol Dis. 2001
PubMed ID: 11300727
Primary myopathy and accumulation of PrPSc-like molecules in peripheral tissues of transgenic mice expressing a prion protein insertional mutation.
Chiesa R, Pestronk A, Schmidt RE, Tourtellotte WG, Ghetti B, Piccardo P, Harris DA
Neurobiol Dis. 2001
PubMed ID: 11300723
A protease-resistant 61-residue prion peptide causes neurodegeneration in transgenic mice.
Supattapone S, Bouzamondo E, Ball HL, Wille H, Nguyen HO, Cohen FE, DeArmond SJ, Prusiner SB, Scott M
Mol Cell Biol. 2001
PubMed ID: 11259607
B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice.
Montrasio F, Cozzio A, Flechsig E, Rossi D, Klein MA, Rülicke T, Raeber AJ, Vosshenrich CA, Proft J, Aguzzi A, Weissmann C
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11274428
Changes in cortical and hippocampal ectonucleotidase activities in mice lacking cellular prion protein.
Pereira GS, Walz R, Bonan CD, Battastini AM, Izquierdo I, Martins VR, Brentani RR, Sarkis JJ
Neurosci Lett. 2001
PubMed ID: 11239719
Prion protein with an E200K mutation displays properties similar to those of the cellular isoform PrP(C).
Rosenmann H, Talmor G, Halimi M, Yanai A, Gabizon R, Meiner Z
J Neurochem. 2001
PubMed ID: 11259483
Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain.
Rossi D, Cozzio A, Flechsig E, Klein MA, Rülicke T, Aguzzi A, Weissmann C
EMBO J. 2001
PubMed ID: 11179214
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Identification of two prion protein regions that modify scrapie incubation time.
Supattapone S, Muramoto T, Legname G, Mehlhorn I, Cohen FE, DeArmond SJ, Prusiner SB, Scott MR
J Virol. 2001
PubMed ID: 11152514
Cleavage of the amino terminus of the prion protein by reactive oxygen species.
McMahon HE, Mangé A, Nishida N, Créminon C, Casanova D, Lehmann S
J Biol Chem. 2001
PubMed ID: 11060296
Increased susceptibility to Kuru of carriers of the PRNP 129 methionine/methionine genotype.
Lee HS, Brown P, Cervenáková L, Garruto RM, Alpers MP, Gajdusek DC, Goldfarb LG
J Infect Dis. 2001
PubMed ID: 11120925
The expression and potential function of cellular prion protein in human lymphocytes.
Li R, Liu D, Zanusso G, Liu T, Fayen JD, Huang JH, Petersen RB, Gambetti P, Sy MS
Cell Immunol. 2001
PubMed ID: 11161453
Flexibility of the murine prion protein and its Asp178Asn mutant investigated by molecular dynamics simulations.
Gsponer J, Ferrara P, Caflisch A
J Mol Graph Model. 2001
PubMed ID: 11775003
Molecular dynamics simulations of wild-type and point mutation human prion protein at normal and elevated temperature.
el-Bastawissy E, Knaggs MH, Gilbert IH
J Mol Graph Model. 2001
PubMed ID: 11775001
Biology of the prion gene complex.
Mastrangelo P, Westaway D
Biochem Cell Biol. 2001
PubMed ID: 11716303
Codon 129 polymorphism of the PRNP gene in normal Polish population and in Creutzfeldt-Jakob disease, and the search for new mutations in PRNP gene.
Bratosiewicz J, Liberski PP, Kulczycki J, Kordek R
Acta Neurobiol Exp (Wars). 2001
PubMed ID: 11584448
Prion diseases of humans and animals: their causes and molecular basis.
Collinge J
Annu Rev Neurosci. 2001
PubMed ID: 11283320
Lack of evidence to support the association of the human prion gene with schizophrenia.
Tsai MT, Su YC, Chen YH, Chen CH
Mol Psychiatry. 2001
PubMed ID: 11244488
Does PRNP gene control the clinical and pathological phenotype of human spongiform transmissible encephalopathies?
Masullo C, Macchi G
Clin Neuropathol. 2001
PubMed ID: 11220690
Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein.
Wong BS, Liu T, Li R, Pan T, Petersen RB, Smith MA, Gambetti P, Perry G, Manson JC, Brown DR, Sy MS
J Neurochem. 2001
PubMed ID: 11208919
The chaperone protein BiP binds to a mutant prion protein and mediates its degradation by the proteasome.
Jin T, Gu Y, Zanusso G, Sy M, Kumar A, Cohen M, Gambetti P, Singh N
J Biol Chem. 2000
PubMed ID: 10970892
Comparative mapping between humans and pigs: localization of 58 anchorage markers (TOASTs) by use of porcine somatic cell and radiation hybrid panels.
Lahbib-Mansais Y, Leroux S, Milan D, Yerle M, Robic A, Jiang Z, André C, Gellin J
Mamm Genome. 2000
PubMed ID: 11130978
Binding of disease-associated prion protein to plasminogen.
Fischer MB, Roeckl C, Parizek P, Schwarz HP, Aguzzi A
Nature. 2000
PubMed ID: 11100730
Bovine prion protein as a modulator of protein kinase CK2.
Meggio F, Negro A, Sarno S, Ruzzene M, Bertoli A, Sorgato MC, Pinna LA
Biochem J. 2000
PubMed ID: 11062072
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Physiological expression of the gene for PrP-like protein, PrPLP/Dpl, by brain endothelial cells and its ectopic expression in neurons of PrP-deficient mice ataxic due to Purkinje cell degeneration.
Li A, Sakaguchi S, Shigematsu K, Atarashi R, Roy BC, Nakaoke R, Arima K, Okimura N, Kopacek J, Katamine S
Am J Pathol. 2000
PubMed ID: 11073804
PrP(C) expression in the peripheral nervous system is a determinant of prion neuroinvasion.
Glatzel M, Aguzzi A
J Gen Virol. 2000
PubMed ID: 11038396
Solution structure of the E200K variant of human prion protein. Implications for the mechanism of pathogenesis in familial prion diseases.
Zhang Y, Swietnicki W, Zagorski MG, Surewicz WK, Sönnichsen FD
J Biol Chem. 2000
PubMed ID: 10954699
Post-translational hydroxylation at the N-terminus of the prion protein reveals presence of PPII structure in vivo.
Gill AC, Ritchie MA, Hunt LG, Steane SE, Davies KG, Bocking SP, Rhie AG, Bennett AD, Hope J
EMBO J. 2000
PubMed ID: 11032800
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Altered intracellular calcium homeostasis in cerebellar granule cells of prion protein-deficient mice.
Herms JW, Korte S, Gall S, Schneider I, Dunker S, Kretzschmar HA
J Neurochem. 2000
PubMed ID: 10987828
Identification of a novel gene encoding a PrP-like protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene.
Li A, Sakaguchi S, Atarashi R, Roy BC, Nakaoke R, Arima K, Okimura N, Kopacek J, Shigematsu K
Cell Mol Neurobiol. 2000
PubMed ID: 10930132
Signal transduction through prion protein.
Mouillet-Richard S, Ermonval M, Chebassier C, Laplanche JL, Lehmann S, Launay JM, Kellermann O
Science. 2000
PubMed ID: 10988071
Follicular dendritic cells and dissemination of Creutzfeldt-Jakob disease.
Manuelidis L, Zaitsev I, Koni P, Lu ZY, Flavell RA, Fritch W
J Virol. 2000
PubMed ID: 10954563
Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss.
Silverman GL, Qin K, Moore RC, Yang Y, Mastrangelo P, Tremblay P, Prusiner SB, Cohen FE, Westaway D
J Biol Chem. 2000
PubMed ID: 10842180
Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice.
Flechsig E, Shmerling D, Hegyi I, Raeber AJ, Fischer M, Cozzio A, von Mering C, Aguzzi A, Weissmann C
Neuron. 2000
PubMed ID: 10985358
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
NMR structures of three single-residue variants of the human prion protein.
Calzolai L, Lysek DA, Guntert P, von Schroetter C, Riek R, Zahn R, Wüthrich K
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10900000
Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation.
Chiesa R, Drisaldi B, Quaglio E, Migheli A, Piccardo P, Ghetti B, Harris DA
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10805813
Identification of three novel mutations (E196K, V203I, E211Q) in the prion protein gene (PRNP) in inherited prion diseases with Creutzfeldt-Jakob disease phenotype.
Peoc'h K, Manivet P, Beaudry P, Attane F, Besson G, Hannequin D, Delasnerie-Lauprêtre N, Laplanche JL
Hum Mutat. 2000
PubMed ID: 10790216
cDNA cloning of turtle prion protein.
Simonic T, Duga S, Strumbo B, Asselta R, Ceciliani F, Ronchi S
FEBS Lett. 2000
PubMed ID: 10708751
A synthetic peptide initiates Gerstmann-Sträussler-Scheinker (GSS) disease in transgenic mice.
Kaneko K, Ball HL, Wille H, Zhang H, Groth D, Torchia M, Tremblay P, Safar J, Prusiner SB, DeArmond SJ, Baldwin MA, Cohen FE
J Mol Biol. 2000
PubMed ID: 10656806
NMR solution structure of the human prion protein.
Zahn R, Liu A, Lührs T, Riek R, von Schroetter C, López García F, Billeter M, Calzolai L, Wider G, Wüthrich K
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10618385
High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes.
Finckh U, Müller-Thomsen T, Mann U, Eggers C, Marksteiner J, Meins W, Binetti G, Alberici A, Hock C, Nitsch RM, Gal A
Am J Hum Genet. 2000
PubMed ID: 10631141
Novel PRNP sequence variant associated with familial encephalopathy.
Cervenáková L, Buetefisch C, Lee HS, Taller I, Stone G, Gibbs CJ, Brown P, Hallett M, Goldfarb LG
Am J Med Genet. 1999
PubMed ID: 10581485
A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy.
Manson JC, Jamieson E, Baybutt H, Tuzi NL, Barron R, McConnell I, Somerville R, Ironside J, Will R, Sy MS, Melton DW, Hope J, Bostock C
EMBO J. 1999
PubMed ID: 10581259
Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity.
White AR, Collins SJ, Maher F, Jobling MF, Stewart LR, Thyer JM, Beyreuther K, Masters CL, Cappai R
Am J Pathol. 1999
PubMed ID: 10550328
Molecular dynamics simulations of human prion protein: importance of correct treatment of electrostatic interactions.
Zuegg J, Gready JE
Biochemistry. 1999
PubMed ID: 10529232
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.
Moore RC, Lee IY, Silverman GL, Harrison PM, Strome R, Heinrich C, Karunaratne A, Pasternak SH, Chishti MA, Liang Y, Mastrangelo P, Wang K, Smit AF, Katamine S, Carlson GA, Cohen FE, Prusiner SB, Melton DW, Tremblay P, Hood LE, Westaway D
J Mol Biol. 1999
PubMed ID: 10525406
Characterization and polyanion-binding properties of purified recombinant prion protein.
Brimacombe DB, Bennett AD, Wusteman FS, Gill AC, Dann JC, Bostock CJ
Biochem J. 1999
PubMed ID: 10477271
Molecular genetics of human prion diseases in Germany.
Windl O, Giese A, Schulz-Schaeffer W, Zerr I, Skworc K, Arendt S, Oberdieck C, Bodemer M, Poser S, Kretzschmar HA
Hum Genet. 1999
PubMed ID: 10987652
Prion protein peptide neurotoxicity can be mediated by astrocytes.
Brown DR
J Neurochem. 1999
PubMed ID: 10461901
Normal inhibitory avoidance learning and anxiety, but increased locomotor activity in mice devoid of PrP(C).
Roesler R, Walz R, Quevedo J, de-Paris F, Zanata SM, Graner E, Izquierdo I, Martins VR, Brentani RR
Brain Res Mol Brain Res. 1999
PubMed ID: 10521590
Prions prevent neuronal cell-line death.
Kuwahara C, Takeuchi AM, Nishimura T, Haraguchi K, Kubosaki A, Matsumoto Y, Saeki K, Matsumoto Y, Yokoyama T, Itohara S, Onodera T
Nature. 1999
PubMed ID: 10421360
Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein.
Wopfner F, Weidenhöfer G, Schneider R, von Brunn A, Gilch S, Schwarz TF, Werner T, Schätzl HM
J Mol Biol. 1999
PubMed ID: 10373359
A mouse prion protein transgene rescues mice deficient for the prion protein gene from purkinje cell degeneration and demyelination.
Nishida N, Tremblay P, Sugimoto T, Shigematsu K, Shirabe S, Petromilli C, Erpel SP, Nakaoke R, Atarashi R, Houtani T, Torchia M, Sakaguchi S, DeArmond SJ, Prusiner SB, Katamine S
Lab Invest. 1999
PubMed ID: 10378511
Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes.
Burbelo PD, Kozak CA, Finegold AA, Hall A, Pirone DM
Gene. 1999
PubMed ID: 10352232
Ancestral origins and worldwide distribution of the PRNP 200K mutation causing familial Creutzfeldt-Jakob disease.
Lee HS, Sambuughin N, Cervenakova L, Chapman J, Pocchiari M, Litvak S, Qi HY, Budka H, del Ser T, Furukawa H, Brown P, Gajdusek DC, Long JC, Korczyn AD, Goldfarb LG
Am J Hum Genet. 1999
PubMed ID: 10090891
Prion protein of 106 residues creates an artifical transmission barrier for prion replication in transgenic mice.
Supattapone S, Bosque P, Muramoto T, Wille H, Aagaard C, Peretz D, Nguyen HO, Heinrich C, Torchia M, Safar J, Cohen FE, DeArmond SJ, Prusiner SB, Scott M
Cell. 1999
PubMed ID: 10102274
The mahogany protein is a receptor involved in suppression of obesity.
Nagle DL, McGrail SH, Vitale J, Woolf EA, Dussault BJ, DiRocco L, Holmgren L, Montagno J, Bork P, Huszar D, Fairchild-Huntress V, Ge P, Keilty J, Ebeling C, Baldini L, Gilchrist J, Burn P, Carlson GA, Moore KJ
Nature. 1999
PubMed ID: 10086355
Scrapie-infected mice and PrP knockout mice share abnormal localization and activity of neuronal nitric oxide synthase.
Keshet GI, Ovadia H, Taraboulos A, Gabizon R
J Neurochem. 1999
PubMed ID: 10037495
Molecular genetics of transmissible spongiform encephalopathies.
Weissmann C
J Biol Chem. 1999
PubMed ID: 9867802
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Copper stimulates endocytosis of the prion protein.
Pauly PC, Harris DA
J Biol Chem. 1998
PubMed ID: 9837873
Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.
Chiesa R, Piccardo P, Ghetti B, Harris DA
Neuron. 1998
PubMed ID: 9883727
Impaired motor coordination in mice lacking prion protein.
Katamine S, Nishida N, Sugimoto T, Noda T, Sakaguchi S, Shigematsu K, Kataoka Y, Nakatani A, Hasegawa S, Moriuchi R, Miyamoto T
Cell Mol Neurobiol. 1998
PubMed ID: 9876879
A differentially expressed prion gene mRNA is found in prion-infected mouse brains and in N2A cells but not in uninfected mice.
Schröder B, Groschup M, Hunsmann G, Bodemer W
Biochem Biophys Res Commun. 1998
PubMed ID: 9792790
Doxycycline control of prion protein transgene expression modulates prion disease in mice.
Tremblay P, Meiner Z, Galou M, Heinrich C, Petromilli C, Lisse T, Cayetano J, Torchia M, Mobley W, Bujard H, DeArmond SJ, Prusiner SB
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9770528
Complete genomic sequence and analysis of the prion protein gene region from three mammalian species.
Lee IY, Westaway D, Smit AF, Wang K, Seto J, Chen L, Acharya C, Ankener M, Baskin D, Cooper C, Yao H, Prusiner SB, Hood LE
Genome Res. 1998
PubMed ID: 9799790
Phenotypic variability of Gerstmann-Sträussler-Scheinker disease is associated with prion protein heterogeneity.
Piccardo P, Dlouhy SR, Lievens PM, Young K, Bird TD, Nochlin D, Dickson DW, Vinters HV, Zimmerman TR, Mackenzie IR, Kish SJ, Ang LC, De Carli C, Pocchiari M, Brown P, Gibbs CJ, Gajdusek DC, Bugiani O, Ironside J, Tagliavini F, Ghetti B
J Neuropathol Exp Neurol. 1998
PubMed ID: 9786248
A 2-year longitudinal study of swimming navigation in mice devoid of the prion protein: no evidence for neurological anomalies or spatial learning impairments.
Lipp HP, Stagliar-Bozicevic M, Fischer M, Wolfer DP
Behav Brain Res. 1998
PubMed ID: 9754876
Prion protein fragment interacts with PrP-deficient cells.
Brown DR, Schmidt B, Kretzschmar HA
J Neurosci Res. 1998
PubMed ID: 9590434
Cultured skin fibroblasts isolated from mice devoid of the prion protein gene express major heat shock proteins in response to heat stress.
Satoh J, Yukitake M, Kurohara K, Nishida N, Katamine S, Miyamoto T, Kuroda Y
Exp Neurol. 1998
PubMed ID: 9582258
Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions.
Shmerling D, Hegyi I, Fischer M, Blättler T, Brandner S, Götz J, Rülicke T, Flechsig E, Cozzio A, von Mering C, Hangartner C, Aguzzi A, Weissmann C
Cell. 1998
PubMed ID: 9568713
Effects of copper on survival of prion protein knockout neurons and glia.
Brown DR, Schmidt B, Kretzschmar HA
J Neurochem. 1998
PubMed ID: 9523587
Prion protein expression in human leukocyte differentiation.
Dodelet VC, Cashman NR
Blood. 1998
PubMed ID: 9473220
Protective prion protein polymorphisms against sporadic Creutzfeldt-Jakob disease.
Shibuya S, Higuchi J, Shin RW, Tateishi J, Kitamoto T
Lancet. 1998
PubMed ID: 9482303
Mice with gene targetted prion protein alterations show that Prnp, Sinc and Prni are congruent.
Moore RC, Hope J, McBride PA, McConnell I, Selfridge J, Melton DW, Manson JC
Nat Genet. 1998
PubMed ID: 9462739
Molecular studies of prion diseases.
Safar J, Prusiner SB
Prog Brain Res. 1998
PubMed ID: 9932423
A crucial role for B cells in neuroinvasive scrapie.
Klein MA, Frigg R, Flechsig E, Raeber AJ, Kalinke U, Bluethmann H, Bootz F, Suter M, Zinkernagel RM, Aguzzi A
Nature. 1997
PubMed ID: 9414161
A prion-linked psychiatric disorder.
Samaia HB, Mari JJ, Vallada HP, Moura RP, Simpson AJ, Brentani RR
Nature. 1997
PubMed ID: 9384372
Prion (PrPSc)-specific epitope defined by a monoclonal antibody.
Korth C, Stierli B, Streit P, Moser M, Schaller O, Fischer R, Schulz-Schaeffer W, Kretzschmar H, Raeber A, Braun U, Ehrensperger F, Hornemann S, Glockshuber R, Riek R, Billeter M, Wüthrich K, Oesch B
Nature. 1997
PubMed ID: 9363892
Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.
Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J, Beier DR
Genome Res. 1997
PubMed ID: 9371744
Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie.
Raeber AJ, Race RE, Brandner S, Priola SA, Sailer A, Bessen RA, Mucke L, Manson J, Aguzzi A, Oldstone MB, Weissmann C, Chesebro B
EMBO J. 1997
PubMed ID: 9321385
The same prion strain causes vCJD and BSE.
Hill AF, Desbruslais M, Joiner S, Sidle KC, Gowland I, Collinge J, Doey LJ, Lantos P
Nature. 1997
PubMed ID: 9333232
Prion protein is necessary for latent learning and long-term memory retention.
Nishida N, Katamine S, Shigematsu K, Nakatani A, Sakamoto N, Hasegawa S, Nakaoke R, Atarashi R, Kataoka Y, Miyamoto T
Cell Mol Neurobiol. 1997
PubMed ID: 9353594
Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform.
James TL, Liu H, Ulyanov NB, Farr-Jones S, Zhang H, Donne DG, Kaneko K, Groth D, Mehlhorn I, Prusiner SB, Cohen FE
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9294167
Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation.
Kaneko K, Zulianello L, Scott M, Cooper CM, Wallace AC, James TL, Cohen FE, Prusiner SB
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9294164
NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231).
Riek R, Hornemann S, Wider G, Glockshuber R, Wüthrich K
FEBS Lett. 1997
PubMed ID: 9280298
Familial spongiform encephalopathy associated with a novel prion protein gene mutation.
Nitrini R, Rosemberg S, Passos-Bueno MR, da Silva LS, Iughetti P, Papadopoulos M, Carrilho PM, Caramelli P, Albrecht S, Zatz M, LeBlanc A
Ann Neurol. 1997
PubMed ID: 9266722
Prion protein NMR structure and species barrier for prion diseases.
Billeter M, Riek R, Wider G, Hornemann S, Glockshuber R, Wüthrich K
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9207082
Of mice and (mad) cows--transgenic mice help to understand prions.
Gabizon R, Taraboulos A
Trends Genet. 1997
PubMed ID: 9242048
Heritable disorder resembling neuronal storage disease in mice expressing prion protein with deletion of an alpha-helix.
Muramoto T, DeArmond SJ, Scott M, Telling GC, Cohen FE, Prusiner SB
Nat Med. 1997
PubMed ID: 9212101
Maid: a maternally transcribed novel gene encoding a potential negative regulator of bHLH proteins in the mouse egg and zygote.
Hwang SY, Oh B, Füchtbauer A, Füchtbauer EM, Johnson KR, Solter D, Knowles BB
Dev Dyn. 1997
PubMed ID: 9186056
Mossy fibre reorganization in the hippocampus of prion protein null mice.
Colling SB, Khana M, Collinge J, Jefferys JG
Brain Res. 1997
PubMed ID: 9163538
Sleep and sleep regulation in normal and prion protein-deficient mice.
Tobler I, Deboer T, Fischer M
J Neurosci. 1997
PubMed ID: 9030645
Characterization of a prion protein (PrP) gene from rabbit; a species with apparent resistance to infection by prions.
Loftus B, Rogers M
Gene. 1997
PubMed ID: 9031631
Characterisation of two promoters for prion protein (PrP) gene expression in neuronal cells.
Baybutt H, Manson J
Gene. 1997
PubMed ID: 9016962
The spectrum of transmissible spongiform encephalopathies.
Weber T, Aguzzi A
Intervirology. 1997
PubMed ID: 9450236
Induction of antibodies against human prion proteins (PrP) by DNA-mediated immunization of PrP0/0 mice.
Krasemann S, Groschup M, Hunsmann G, Bodemer W
J Immunol Methods. 1996
PubMed ID: 8982352
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains.
Vey M, Pilkuhn S, Wille H, Nixon R, DeArmond SJ, Smart EJ, Anderson RG, Taraboulos A, Prusiner SB
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8962161
Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system.
Brandner S, Raeber A, Sailer A, Blättler T, Fischer M, Weissmann C, Aguzzi A
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8917559
Mutation of the prion protein gene at codon 208 in familial Creutzfeldt-Jakob disease.
Mastrianni JA, Iannicola C, Myers RM, DeArmond S, Prusiner SB
Neurology. 1996
PubMed ID: 8909447
How many phenotypes from one genotype? The case of Prion diseases.
Kacser H, Small JR
J Theor Biol. 1996
PubMed ID: 8944151
Polymorphism at codon 129 or codon 219 of PRNP and clinical heterogeneity in a previously unreported family with Gerstmann-Sträussler-Scheinker disease (PrP-P102L mutation).
Barbanti P, Fabbrini G, Salvatore M, Petraroli R, Cardone F, Maras B, Equestre M, Macchi G, Lenzi GL, Pocchiari M
Neurology. 1996
PubMed ID: 8797472
Familial Creutzfeldt-Jakob disease with a five-repeat octapeptide insert mutation.
Cochran EJ, Bennett DA, Cervenáková L, Kenney K, Bernard B, Foster NL, Benson DF, Goldfarb LG, Brown P
Neurology. 1996
PubMed ID: 8797471
Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein.
Tatzelt J, Maeda N, Pekny M, Yang SL, Betsholtz C, Eliasson C, Cayetano J, Camerino AP, DeArmond SJ, Prusiner SB
Neurology. 1996
PubMed ID: 8757019
Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice.
Telling GC, Haga T, Torchia M, Tremblay P, DeArmond SJ, Prusiner SB
Genes Dev. 1996
PubMed ID: 8698234
NMR structure of the mouse prion protein domain PrP(121-321).
Riek R, Hornemann S, Wider G, Billeter M, Glockshuber R, Wüthrich K
Nature. 1996
PubMed ID: 8700211
Strain specific and common pathogenic events in murine models of scrapie and bovine spongiform encephalopathy.
Lasmézas CI, Deslys JP, Demaimay R, Adjou KT, Hauw JJ, Dormont D
J Gen Virol. 1996
PubMed ID: 8758005
Prion protein PrPc interacts with molecular chaperones of the Hsp60 family.
Edenhofer F, Rieger R, Famulok M, Wendler W, Weiss S, Winnacker EL
J Virol. 1996
PubMed ID: 8676499
Humanized prion protein knock-in by Cre-induced site-specific recombination in the mouse.
Kitamoto T, Nakamura K, Nakao K, Shibuya S, Shin RW, Gondo Y, Katsuki M, Tateishi J
Biochem Biophys Res Commun. 1996
PubMed ID: 8651915
Hippocampal slices from prion protein null mice: disrupted Ca(2+)-activated K+ currents.
Colling SB, Collinge J, Jefferys JG
Neurosci Lett. 1996
PubMed ID: 8734907
Altered circadian activity rhythms and sleep in mice devoid of prion protein.
Tobler I, Gaus SE, Deboer T, Achermann P, Fischer M, Rülicke T, Moser M, Oesch B, McBride PA, Manson JC
Nature. 1996
PubMed ID: 8602267
Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene.
Sakaguchi S, Katamine S, Nishida N, Moriuchi R, Shigematsu K, Sugimoto T, Nakatani A, Kataoka Y, Houtani T, Shirabe S, Okada H, Hasegawa S, Miyamoto T, Noda T
Nature. 1996
PubMed ID: 8606772
A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex.
Zuberi AR, Nguyen HQ, Auman HJ, Taylor BA, Roopenian DC
Genomics. 1996
PubMed ID: 8617512
Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus.
Lledo PM, Tremblay P, DeArmond SJ, Prusiner SB, Nicoll RA
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8637886
Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.
Fischer M, Rülicke T, Raeber A, Sailer A, Moser M, Oesch B, Brandner S, Aguzzi A, Weissmann C
EMBO J. 1996
PubMed ID: 8635458
Identification of a promoter region in the rat prion protein gene.
Saeki K, Matsumoto Y, Matsumoto Y, Onodera T
Biochem Biophys Res Commun. 1996
PubMed ID: 8619825
Normal host prion protein necessary for scrapie-induced neurotoxicity.
Brandner S, Isenmann S, Raeber A, Fischer M, Sailer A, Kobayashi Y, Marino S, Weissmann C, Aguzzi A
Nature. 1996
PubMed ID: 8552188
Three-exon structure of the gene encoding the rat prion protein and its expression in tissues.
Saeki K, Matsumoto Y, Hirota Y, Matsumoto Y, Onodera T
Virus Genes. 1996
PubMed ID: 8879116
The association between PrP and infectivity in scrapie and BSE infected mouse brain.
Somerville RA, Dunn AJ
Arch Virol. 1996
PubMed ID: 8634020
Patch-clamp analysis of synaptic transmission to cerebellar purkinje cells of prion protein knockout mice.
Herms JW, Kretzchmar HA, Titz S, Keller BU
Eur J Neurosci. 1995
PubMed ID: 8845956
Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent.
Sakaguchi S, Katamine S, Shigematsu K, Nakatani A, Moriuchi R, Nishida N, Kurokawa K, Nakaoke R, Sato H, Jishage K
J Virol. 1995
PubMed ID: 7494265
A mutant prion protein displays an aberrant membrane association when expressed in cultured cells.
Lehmann S, Harris DA
J Biol Chem. 1995
PubMed ID: 7592679
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein.
Telling GC, Scott M, Mastrianni J, Gabizon R, Torchia M, Cohen FE, DeArmond SJ, Prusiner SB
Cell. 1995
PubMed ID: 7553876
Double replacement gene targeting for the production of a series of mouse strains with different prion protein gene alterations.
Moore RC, Redhead NJ, Selfridge J, Hope J, Manson JC, Melton DW
Biotechnology (N Y). 1995
PubMed ID: 9636277
Truncated forms of the human prion protein in normal brain and in prion diseases.
Chen SG, Teplow DB, Parchi P, Teller JK, Gambetti P, Autilio-Gambetti L
J Biol Chem. 1995
PubMed ID: 7642585
First experimental transmission of fatal familial insomnia.
Tateishi J, Brown P, Kitamoto T, Hoque ZM, Roos R, Wollman R, Cervenáková L, Gajdusek DC
Nature. 1995
PubMed ID: 7630420
A candidate marsupial PrP gene reveals two domains conserved in mammalian PrP proteins.
Windl O, Dempster M, Estibeiro P, Lathe R
Gene. 1995
PubMed ID: 7622046
Genomic cloning of mouse MIF (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes.
Kozak CA, Adamson MC, Buckler CE, Segovia L, Paralkar V, Wistow G
Genomics. 1995
PubMed ID: 7558020
Gerstmann-Sträussler-Scheinker disease with mutation at codon 102 and methionine at codon 129 of PRNP in previously unreported patients.
Young K, Jones CK, Piccardo P, Lazzarini A, Golbe LI, Zimmerman TR, Dickson DW, McLachlan DC, St George-Hyslop P, Lennox A
Neurology. 1995
PubMed ID: 7783876
The cellular prion protein (PrP) selectively binds to Bcl-2 in the yeast two-hybrid system.
Kurschner C, Morgan JI
Brain Res Mol Brain Res. 1995
PubMed ID: 7609638
SSCP analysis and sequencing of the human prion protein gene (PRNP) detects two different 24 bp deletions in an atypical Alzheimer's disease family.
Perry RT, Go RC, Harrell LE, Acton RT
Am J Med Genet. 1995
PubMed ID: 7485229
Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein.
Whittington MA, Sidle KC, Gowland I, Meads J, Hill AF, Palmer MS, Jefferys JG, Collinge J
Nat Genet. 1995
PubMed ID: 7719349
Prion disease with 144 base pair insertion in a Japanese family line.
Oda T, Kitamoto T, Tateishi J, Mitsuhashi T, Iwabuchi K, Haga C, Oguni E, Kato Y, Tominaga I, Yanai K
Acta Neuropathol. 1995
PubMed ID: 7572084
PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology.
Manson JC, Clarke AR, McBride PA, McConnell I, Hope J
Neurodegeneration. 1994
PubMed ID: 7842304
A variant of Gerstmann-Sträussler-Scheinker disease carrying codon 105 mutation with codon 129 polymorphism of the prion protein gene: a clinicopathological study.
Itoh Y, Yamada M, Hayakawa M, Shozawa T, Tanaka J, Matsushita M, Kitamoto T, Tateishi J, Otomo E
J Neurol Sci. 1994
PubMed ID: 7699395
High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene.
Büeler H, Raeber A, Sailer A, Fischer M, Aguzzi A, Weissmann C
Mol Med. 1994
PubMed ID: 8790598
Prion protein is necessary for normal synaptic function.
Collinge J, Whittington MA, Sidle KC, Smith CJ, Palmer MS, Clarke AR, Jefferys JG
Nature. 1994
PubMed ID: 8035877
Structure and polymorphism of the mouse prion protein gene.
Westaway D, Cooper C, Turner S, Da Costa M, Carlson GA, Prusiner SB
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7912827
Astrocyte gene expression in experimental mouse scrapie.
Lazarini F, Boussin F, Deslys JP, Tardy M, Dormont D
J Comp Pathol. 1994
PubMed ID: 7962730
No propagation of prions in mice devoid of PrP.
Sailer A, Büeler H, Fischer M, Aguzzi A, Weissmann C
Cell. 1994
PubMed ID: 7912659
Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.
Carlson GA, Ebeling C, Yang SL, Telling G, Torchia M, Groth D, Westaway D, DeArmond SJ, Prusiner SB
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7911243
Comparison of expression patterns of PrP mRNA in the developing sheep and mouse.
Hunter N, Manson JC, Charleson FC, Hope J
Ann N Y Acad Sci. 1994
PubMed ID: 8030958
PrP-deficient mice are resistant to scrapie.
Weissmann C, Büeler H, Fischer M, Sailer A, Aguzzi A, Aguet M
Ann N Y Acad Sci. 1994
PubMed ID: 8030944
Expression of polyubiquitin and heat-shock protein 70 genes increases in the later stages of disease progression in scrapie-infected mouse brain.
Kenward N, Hope J, Landon M, Mayer RJ
J Neurochem. 1994
PubMed ID: 7512619
129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal.
Manson JC, Clarke AR, Hooper ML, Aitchison L, McConnell I, Hope J
Mol Neurobiol. 1994
PubMed ID: 7999308
Susceptibility to scrapie in mice is dependent on PrPC.
Weissmann C, Büeler H, Fischer M, Sauer A, Aguet M
Philos Trans R Soc Lond B Biol Sci. 1994
PubMed ID: 7913762
Mutation in codon 200 and polymorphism in codon 129 of the prion protein gene in Libyan Jews with Creutzfeldt-Jakob disease.
Gabizon R, Rosenman H, Meiner Z, Kahana I, Kahana E, Shugart Y, Ott J, Prusiner SB
Philos Trans R Soc Lond B Biol Sci. 1994
PubMed ID: 7913755
Genetics of prion diseases and prion diversity in mice.
Carlson GA, DeArmond SJ, Torchia M, Westaway D, Prusiner SB
Philos Trans R Soc Lond B Biol Sci. 1994
PubMed ID: 7913753
Effect of Sinc genotype, agent isolate and route of infection on the accumulation of protease-resistant PrP in non-central nervous system tissues during the development of murine scrapie.
Farquhar CF, Dornan J, Somerville RA, Tunstall AM, Hope J
J Gen Virol. 1994
PubMed ID: 7907357
Scrapie, Creutzfeldt-Jakob disease and bovine spongiform encephalopathy: the key role of a nerve membrane protein (PrP).
Hope J, Chong A
Biochem Soc Trans. 1994
PubMed ID: 7911437
Japanese family with Creutzfeldt-Jakob disease with codon 200 point mutation of the prion protein gene.
Inoue I, Kitamoto T, Doh-ura K, Shii H, Goto I, Tateishi J
Neurology. 1994
PubMed ID: 7906019
Prion protein (PrP) is not involved in the pathogenesis of spongiform encephalopathy in zitter rats.
Gomi H, Ikeda T, Kunieda T, Itohara S, Prusiner SB, Yamanouchi K
Neurosci Lett. 1994
PubMed ID: 7909925
Insights into the role of the immune system in prion diseases.
Berg LJ
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7904753
A missense mutation at codon 105 with codon 129 polymorphism of the prion protein gene in a new variant of Gerstmann-Sträussler-Scheinker disease.
Yamada M, Itoh Y, Fujigasaki H, Naruse S, Kaneko K, Kitamoto T, Tateishi J, Otomo E, Hayakawa M, Tanaka J
Neurology. 1993
PubMed ID: 7902972
A new point mutation of the prion protein gene in Creutzfeldt-Jakob disease.
Pocchiari M, Salvatore M, Cutruzzolá F, Genuardi M, Allocatelli CT, Masullo C, Macchi G, Alemá G, Galgani S, Xi YG
Ann Neurol. 1993
PubMed ID: 7902693
Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.
Prusiner SB, Groth D, Serban A, Koehler R, Foster D, Torchia M, Burton D, Yang SL, DeArmond SJ
Proc Natl Acad Sci U S A. 1993
PubMed ID: 7902565
Genetic and infectious prion diseases.
Prusiner SB
Arch Neurol. 1993
PubMed ID: 8105771
High-resolution mapping of a minor histocompatibility antigen gene on mouse chromosome 2.
Zuberi AR, Roopenian DC
Mamm Genome. 1993
PubMed ID: 8118101
Mice devoid of PrP are resistant to scrapie.
Büeler H, Aguzzi A, Sailer A, Greiner RA, Autenried P, Aguet M, Weissmann C
Cell. 1993
PubMed ID: 8100741
Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse.
Carlson GA, Ebeling C, Torchia M, Westaway D, Prusiner SB
Genetics. 1993
PubMed ID: 8462855
Novel missense variants of prion protein in Creutzfeldt-Jakob disease or Gerstmann-Sträussler syndrome.
Kitamoto T, Ohta M, Doh-ura K, Hitoshi S, Terao Y, Tateishi J
Biochem Biophys Res Commun. 1993
PubMed ID: 8461023
Kinetics of expression of prion protein in uninfected and scrapie-infected N2a mouse neuroblastoma cells.
Pfeifer K, Bachmann M, Schröder HC, Forrest J, Müller WE
Cell Biochem Funct. 1993
PubMed ID: 8095862
Role of the PrP gene in transmissible spongiform encephalopathies.
Weissmann C, Büeler H, Fischer M, Aguet M
Intervirology. 1993
PubMed ID: 8407244
Mutations and polymorphisms in the prion protein gene.
Palmer MS, Collinge J
Hum Mutat. 1993
PubMed ID: 8364585
Fatal familial insomnia and familial Creutzfeldt-Jakob disease: disease phenotype determined by a DNA polymorphism.
Goldfarb LG, Petersen RB, Tabaton M, Brown P, LeBlanc AC, Montagna P, Cortelli P, Julien J, Vital C, Pendelbury WW
Science. 1992
PubMed ID: 1439789
Prion protein preamyloid and amyloid deposits in Gerstmann-Sträussler-Scheinker disease, Indiana kindred.
Giaccone G, Verga L, Bugiani O, Frangione B, Serban D, Prusiner SB, Farlow MR, Ghetti B, Tagliavini F
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1357663
Deletion in the prion protein gene in a demented patient.
Diedrich JF, Knopman DS, List JF, Olson K, Frey WH, Emory CR, Sung JH, Haase AT
Hum Mol Genet. 1992
PubMed ID: 1363802
Accumulation of transcripts coding for prion protein in human astrocytes during infection with human immunodeficiency virus.
Müller WE, Pfeifer K, Forrest J, Rytik PG, Eremin VF, Popov SA, Schröder HC
Biochim Biophys Acta. 1992
PubMed ID: 1351748
Inherited prion disease with 144 base pair gene insertion. 1. Genealogical and molecular studies.
Poulter M, Baker HF, Frith CD, Leach M, Lofthouse R, Ridley RM, Shah T, Owen F, Collinge J, Brown J
Brain. 1992
PubMed ID: 1352724
The prion protein gene: a role in mouse embryogenesis?
Manson J, West JD, Thomson V, McBride P, Kaufman MH, Hope J
Development. 1992
PubMed ID: 1353438
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein.
Büeler H, Fischer M, Lang Y, Bluethmann H, Lipp HP, DeArmond SJ, Prusiner SB, Aguet M, Weissmann C
Nature. 1992
PubMed ID: 1373228
Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles.
Hsiao K, Dlouhy SR, Farlow MR, Cass C, Da Costa M, Conneally PM, Hodes ME, Ghetti B, Prusiner SB
Nat Genet. 1992
PubMed ID: 1363810
Fatal familial insomnia: a second kindred with mutation of prion protein gene at codon 178.
Medori R, Montagna P, Tritschler HJ, LeBlanc A, Cortelli P, Tinuper P, Lugaresi E, Gambetti P
Neurology. 1992
PubMed ID: 1347910
Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene.
Medori R, Tritschler HJ, LeBlanc A, Villare F, Manetto V, Chen HY, Xue R, Leal S, Montagna P, Cortelli P
N Engl J Med. 1992
PubMed ID: 1346338
Atypical Creutzfeldt-Jakob disease in an American family with an insert mutation in the PRNP amyloid precursor gene.
Brown P, Goldfarb LG, McCombie WR, Nieto A, Squillacote D, Sheremata W, Little BW, Godec MS, Gibbs CJ, Gajdusek DC
Neurology. 1992
PubMed ID: 1736177
Transmissible familial Creutzfeldt-Jakob disease associated with five, seven, and eight extra octapeptide coding repeats in the PRNP gene.
Goldfarb LG, Brown P, McCombie WR, Goldgaber D, Swergold GD, Wills PR, Cervenakova L, Baron H, Gibbs CJ, Gajdusek DC
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1683708
Assignment of secretogranin I locus to mouse chromosome 2 by in situ hybridization and interspecific backcross analysis.
Jenkins NA, Mattei MG, Gilbert DJ, Linard CG, Mbikay M, Chretien M, Copeland NG
Genomics. 1991
PubMed ID: 1685143
Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes.
Diedrich JF, Minnigan H, Carp RI, Whitaker JN, Race R, Frey W, Haase AT
J Virol. 1991
PubMed ID: 1870200
Creutzfeldt-Jacob disease associated with the PRNP codon 200Lys mutation: an analysis of 45 families.
Goldfarb LG, Brown P, Mitrovà E, Cervenáková L, Goldin L, Korczyn AD, Chapman J, Gálvez S, Cartier L, Rubenstein R
Eur J Epidemiol. 1991
PubMed ID: 1684755
Genomic structure of the human prion protein gene.
Puckett C, Concannon P, Casey C, Hood L
Am J Hum Genet. 1991
PubMed ID: 1678248
Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jakob disease.
Palmer MS, Dryden AJ, Hughes JT, Collinge J
Nature. 1991
PubMed ID: 1677164
Regulation of the glial fibrillary acidic protein, beta actin and prion protein mRNAs during brain development in mouse.
Lazarini F, Deslys JP, Dormont D
Brain Res Mol Brain Res. 1991
PubMed ID: 1681406
Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice.
Westaway D, Mirenda CA, Foster D, Zebarjadian Y, Scott M, Torchia M, Yang SL, Serban H, DeArmond SJ, Ebeling C
Neuron. 1991
PubMed ID: 1676894
Localization of the human gene allowing infection by gibbon ape leukemia virus to human chromosome region 2q11-q14 and to the homologous region on mouse chromosome 2.
Kaelbling M, Eddy R, Shows TB, Copeland NG, Gilbert DJ, Jenkins NA, Klinger HP, O'Hara B
J Virol. 1991
PubMed ID: 1672162
Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58.
Tagliavini F, Prelli F, Ghiso J, Bugiani O, Serban D, Prusiner SB, Farlow MR, Ghetti B, Frangione B
EMBO J. 1991
PubMed ID: 1672107
New mutation in scrapie amyloid precursor gene (at codon 178) in Finnish Creutzfeldt-Jakob kindred.
Goldfarb LG, Haltia M, Brown P, Nieto A, Kovanen J, McCombie WR, Trapp S, Gajdusek DC
Lancet. 1991
PubMed ID: 1671440
The scrapie fibril protein and its cellular isoform.
Hope J, Manson J
Curr Top Microbiol Immunol. 1991
PubMed ID: 1687385
The scrapie agent: "a virus by any other name".
Rohwer RG
Curr Top Microbiol Immunol. 1991
PubMed ID: 1687381
Genetics of prion diversity and host susceptibility.
Carlson GA
Curr Top Microbiol Immunol. 1991
PubMed ID: 1687380
Prion protein genes: evolutionary and functional aspects.
Oesch B, Westaway D, Prusiner SB
Curr Top Microbiol Immunol. 1991
PubMed ID: 1687379
Prion biology and diseases.
Prusiner SB
Harvey Lect. 1991
PubMed ID: 1670551
Mutation in codon 200 of scrapie amyloid protein gene in two clusters of Creutzfeldt-Jakob disease in Slovakia.
Goldfarb LG, Mitrová E, Brown P, Toh BK, Gajdusek DC
Lancet. 1990
PubMed ID: 1975028
An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob disease.
Owen F, Poulter M, Shah T, Collinge J, Lofthouse R, Baker H, Ridley R, McVey J, Crow TJ
Brain Res Mol Brain Res. 1990
PubMed ID: 2159587
Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.
Dickinson ME, Kobrin MS, Silan CM, Kingsley DM, Justice MJ, Miller DA, Ceci JD, Lock LF, Lee A, Buchberg AM
Genomics. 1990
PubMed ID: 1970330
A molecular genetic linkage map of mouse chromosome 2.
Siracusa LD, Silan CM, Justice MJ, Mercer JA, Bauskin AR, Ben-Neriah Y, Duboule D, Hastie ND, Copeland NG, Jenkins NA
Genomics. 1990
PubMed ID: 1970329
Creutzfeldt-Jakob disease patients with congophilic kuru plaques have the missense variant prion protein common to Gerstmann-Sträussler syndrome.
Doh-ura K, Tateishi J, Kitamoto T, Sasaki H, Sakaki Y
Ann Neurol. 1990
PubMed ID: 2180366
Analysis of linkage between scrapie incubation period and the prion protein gene in mice.
Race RE, Graham K, Ernst D, Caughey B, Chesebro B
J Gen Virol. 1990
PubMed ID: 1968507
Mutations in familial Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker's syndrome.
Goldgaber D, Goldfarb LG, Brown P, Asher DM, Brown WT, Lin S, Teener JW, Feinstone SM, Rubenstein R, Kascsak RJ
Exp Neurol. 1989
PubMed ID: 2572450
Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively.
Glaser T, Matthews KE, Hudson JW, Seth P, Housman DE, Crerar MM
Genomics. 1989
PubMed ID: 2575583
Pro----leu change at position 102 of prion protein is the most common but not the sole mutation related to Gerstmann-Sträussler syndrome.
Doh-ura K, Tateishi J, Sasaki H, Kitamoto T, Sakaki Y
Biochem Biophys Res Commun. 1989
PubMed ID: 2783132
Diagnosis of Gerstmann-Sträussler syndrome in familial dementia with prion protein gene analysis.
Collinge J, Harding AE, Owen F, Poulter M, Lofthouse R, Boughey AM, Shah T, Crow TJ
Lancet. 1989
PubMed ID: 2567794
Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome.
Hsiao K, Baker HF, Crow TJ, Poulter M, Owen F, Terwilliger JD, Westaway D, Ott J, Prusiner SB
Nature. 1989
PubMed ID: 2564168
Genetics and polymorphism of the mouse prion gene complex: control of scrapie incubation time.
Carlson GA, Goodman PA, Lovett M, Taylor BA, Marshall ST, Peterson-Torchia M, Westaway D, Prusiner SB
Mol Cell Biol. 1988
PubMed ID: 3149717
Molecular pathology of scrapie-associated fibril protein (PrP) in mouse brain affected by the ME7 strain of scrapie.
Hope J, Multhaup G, Reekie LJ, Kimberlin RH, Beyreuther K
Eur J Biochem. 1988
PubMed ID: 2894984
Distinct prion proteins in short and long scrapie incubation period mice.
Westaway D, Goodman PA, Mirenda CA, McKinley MP, Carlson GA, Prusiner SB
Cell. 1987
PubMed ID: 2890436
Cloning of rat "prion-related protein" cDNA.
Liao YC, Tokes Z, Lim E, Lackey A, Woo CH, Button JD, Clawson GA
Lab Invest. 1987
PubMed ID: 2889848
PrP and the nature of the scrapie agent.
Diener TO
Cell. 1987
PubMed ID: 2884041
Assignment of the human and mouse prion protein genes to homologous chromosomes.
Sparkes RS, Simon M, Cohn VH, Fournier RE, Lem J, Klisak I, Heinzmann C, Blatt C, Lucero M, Mohandas T
Proc Natl Acad Sci U S A. 1986
PubMed ID: 3094007
Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent.
Locht C, Chesebro B, Race R, Keith JM
Proc Natl Acad Sci U S A. 1986
PubMed ID: 3462700
Linkage of prion protein and scrapie incubation time genes.
Carlson GA, Kingsbury DT, Goodman PA, Coleman S, Marshall ST, DeArmond S, Westaway D, Prusiner SB
Cell. 1986
PubMed ID: 3015416
Molecular cloning of a human prion protein cDNA.
Kretzschmar HA, Stowring LE, Westaway D, Stubblebine WH, Prusiner SB, Dearmond SJ
DNA. 1986
PubMed ID: 3755672
Human prion protein cDNA: molecular cloning, chromosomal mapping, and biological implications.
Liao YC, Lebo RV, Clawson GA, Smuckler EA
Science. 1986
PubMed ID: 3014653
Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain.
Chesebro B, Race R, Wehrly K, Nishio J, Bloom M, Lechner D, Bergstrom S, Robbins K, Mayer L, Keith JM
Nature. 1985
PubMed ID: 3923361
A cellular gene encodes scrapie PrP 27-30 protein.
Oesch B, Westaway D, Wälchli M, McKinley MP, Kent SB, Aebersold R, Barry RA, Tempst P, Teplow DB, Hood LE
Cell. 1985
PubMed ID: 2859120
Novel proteinaceous infectious particles cause scrapie.
Prusiner SB
Science. 1982
PubMed ID: 6801762
Identification of a gene which controls the incubation period of some strains of scrapie agent in mice.
Dickinson AG, Meikle VM, Fraser H
J Comp Pathol. 1968
PubMed ID: 4970191

Model Organism Phenotype Links from MGI Top Help

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	Human	Mouse	Rat
Entrez Gene	5621	19122	24686
EnsEMBL Gene(s)	ENSG00000171867	ENSMUSG00000079037	ENSRNOG00000021259
Unigene	Hs.472010	Mm.648	Rn.3936
Homologene	PRNP	Prnp	Prnp
OMIM	176640	N/A	N/A
GeneCards	PRNP	N/A	N/A
Beta Cell Genomics	DT.100882026 DT.100882036 DT.120809501 DT.91716071 DT.91729019 DT.92456884 DT.92456894	DT.101133252 DT.495766 DT.91401166 DT.94217511	N/A
Reactome	P04156	N/A	N/A
Plasma Peptide Atlas	ENSP00000368748	N/A	N/A
WikiGenes	5621	19122	24686

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Interactor	Interactor	Sources	Classification	Pubmed IDs
PRNP	FAM27E3	IntAct	empirical	18482256
PRNP	STIP1	HPRD	empirical	12093732
PRNP	WDR5	IntAct	empirical	18482256
PRNP	CIRBP	IntAct	empirical	18482256
PRNP	CLU	HPRD, MINT	empirical	15146195
PRNP	PLK3	IntAct	empirical	18482256
PRNP	CNP	IntAct	empirical	18482256
PRNP	CNTN1	HPRD, MINT	empirical	15146195
PRNP	PTRH1	IntAct	empirical	18482256
PRNP	CSN3	IntAct	empirical	18482256
PRNP	CSNK2A1	HPRD	empirical	11062072
PRNP	CSNK2A2	HPRD	empirical	11062072
PRNP	CSNK2B	HPRD	empirical	11062072
PRNP	AIFM3	IntAct	empirical	18482256
PRNP	DNM1	HPRD, MINT	empirical	15146195
PRNP	DPP6	HPRD, MINT	empirical	15146195
PRNP	FGF13	IntAct	empirical	18482256
PRNP	FHL1	IntAct	empirical	18482256
PRNP	CLSTN1	HPRD, MINT	empirical	15146195
PRNP	ALDOC	IntAct	empirical	16294306
PRNP	EIF2C1	IntAct	empirical	18482256
PRNP	ZNF740	IntAct	empirical	18482256
PRNP	GRB2	HPRD	empirical	11571277
PRNP	NOB1	IntAct	empirical	18482256
PRNP	ABT1	IntAct	empirical	18482256
PRNP	BAZ2B	IntAct	empirical	18482256
PRNP	HNRNPA2B1	IntAct	empirical	16294306
PRNP	HOXA1	IntAct	empirical	18482256
PRNP	APBB1	HPRD, MINT	empirical	15146195
PRNP	HSPA5	HPRD, MINT	empirical	15146195
PRNP	HSPD1	HPRD	empirical	8676499
PRNP	APLP1	HPRD, MINT	empirical	15146195
PRNP	APLP2	HPRD, MINT	empirical	15146195
PRNP	APOE	HPRD, MINT	empirical	15146195
PRNP	APP	IntAct	empirical	17934213 16286452
PRNP	L1CAM	HPRD, MINT	empirical	15146195
PRNP	LSAMP	HPRD, MINT	empirical	15146195
PRNP	MAG	HPRD, MINT	empirical	15146195
PRNP	MOG	HPRD, MINT	empirical	15146195
PRNP	MPG	IntAct	empirical	18482256
PRNP	NCAM1	HPRD, MINT, Reactome	empirical	15146195
PRNP	NCAM2	HPRD, MINT	empirical	15146195
PRNP	C18orf56	IntAct	empirical	18482256
PRNP	OPCML	HPRD, MINT	empirical	15146195
PRNP	P4HB	HPRD, MINT	empirical	15146195
PRNP	NTM	MINT	empirical	15146195
PRNP	DDX47	IntAct	empirical	18482256
PRNP	CWC15	IntAct	empirical	18482256
PRNP	PLG	HPRD	empirical	11100730
PRNP	FAM64A	IntAct	empirical	18482256
PRNP	PPARG	IntAct	empirical	20195357
PRNP	RNPC3	IntAct	empirical	18482256
PRNP	NHP2	IntAct	empirical	18482256
PRNP	RBM22	IntAct	empirical	18482256
PRNP	ADAP2	IntAct	empirical	18482256
PRNP	ARHGAP15	IntAct	empirical	18482256
PRNP	PRNP	IntAct	empirical	16286452
PRNP	PSMA3	HPRD, MINT, IntAct	empirical	16713569
PRNP	KIAA1191	IntAct	empirical	18482256
PRNP	ZFYVE28	IntAct	empirical	18482256
PRNP	MARK4	IntAct	empirical	18482256
PRNP	PVRL1	HPRD, MINT	empirical	15146195
PRNP	RPL41	IntAct	empirical	18482256
PRNP	TMEM237	IntAct	empirical	18482256
PRNP	SURF2	IntAct	empirical	18482256
PRNP	YWHAB	IntAct	empirical	16635246
PRNP	ZNF192	IntAct	empirical	18482256
PRNP	SCNM1	IntAct	empirical	18482256
PRNP	ERI3	HPRD	empirical	11571277
PRNP	BAG6	HPRD, MINT, IntAct	empirical	16169070
PRNP	ZNF408	IntAct	empirical	18482256
PRNP	TSC22D4	HPRD, MINT, IntAct	empirical	16713569
PRNP	SPARCL1	HPRD, MINT	empirical	15146195
PRNP	WIBG	IntAct	empirical	18482256
PRNP	C7orf50	IntAct	empirical	18482256
PRNP	DYRK3	IntAct	empirical	18482256
PRNP	CIRH1A	IntAct	empirical	18482256
PRNP	PPFIBP2	IntAct	empirical	18482256
PRNP	TSLP	IntAct	empirical	18482256
PRNP	CAV1	HPRD	empirical	10988071
PRNP	ADAM23	HPRD, MINT	empirical	15146195
PRNP	IER3	IntAct	empirical	18482256
PRNP	CCDC149	IntAct	empirical	18482256
PRNP	MTG1	IntAct	empirical	18482256
PRNP	PPP1R14A	IntAct	empirical	18482256
PRNP	TBPL1	IntAct	empirical	18482256
PRNP	PDE4DIP	IntAct	empirical	18482256