Mm

MAPK13

  Summary   Top   Help
Gene Description:   mitogen-activated protein kinase 13; mitogen activated protein kinase 13
Synonyms:   Mapk13, PRKM13, SAPK4, MAPK-13, Prkm13, Serk4, MAPK13, p38delta
Orthologs:   Human MAPK13 (protein-coding), Mouse Mapk13 (protein-coding), Rat Mapk13 (protein-coding)
 Sources
Human-Mouse: HomoloGene, MGD, RGD, Ensembl, Inparanoid
Human-Rat: HomoloGene, MGD, RGD, Ensembl, Inparanoid
Mouse-Rat: HomoloGene, MGD, RGD, Ensembl, Inparanoid
Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG
  Species Overlaps from T1DBase   Top   Help
  Species (Expand and mouseover the colored boxes for more details)

  Overlapping regions from T1DBase Curated Regions   Top   Help
Other Regions Overlapping this Feature:  Mouse: 1
  Linkage Regions: 1 Available
Locus Species Chromosomal Location Mb Number of genes Linkage and Congenic Studies
Mouse Idd16 Mouse chr17:26182038..29268449 3.09 81 3 no lod score
  Gene Annotation Overview from Genome Browser   Top   Help
  (Human) GRCh37 - chr6:36095586..36112301 (16.71 kb)  View in Genome Browser
  (Mouse) GRCm38 - chr17:28769307..28778704 (9.40 kb)  View in Genome Browser
  (Rat) Rnor_5.0 - chr20:8272098..8281191 (9.09 kb)  View in Genome Browser
  Haematopoietic Tissue Expression from HaemAtlas   Top   Help
  Haematopoietic Tissue Expression Table for MAPK13:
  Expression Legend
CD Marker Cell Type Lineage
EB Erythroblast PRECURSOR
MK Megakaryocyte PRECURSOR
CD66b Granulocyte MYELOID
CD14 Monocyte MYELOID
CD19 B Lymphocyte LYMPHOID
CD8 Tc Lymphocyte LYMPHOID
CD4 Th Lymphocyte LYMPHOID
CD56 Natural Killer cell LYMPHOID
Symbol Expression Level
High High
Moderate Moderate
Low Low
Not Detected Not Detected
  Beta Cell Expression from Beta Cell Gene Atlas   Top   Help
  Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat
ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas
 
 
 
 
 
 
 
 
 
 
 
 
 
  Expression Legend
 Range
0
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
100
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 No Data

The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.

A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

  Tissue Expression from BioGPS Gene Atlas   Top   Help
  Tissues Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
 
/tissue_expression/tmp/atlas-PB_CD14+_Monocytes.png /tissue_expression/tmp/atlas-PB_CD56+_NK_Cells.png /tissue_expression/tmp/atlas-PB_CD19-_B_Cells.png /tissue_expression/tmp/atlas-PB_CD4+_T_Cells.png /tissue_expression/tmp/atlas-PB_CD8+_T_Cells.png /tissue_expression/tmp/atlas-PB_BDCA4+_Dendritic_Cells.png /tissue_expression/tmp/atlas-721_B_Lymphoblasts.png /tissue_expression/tmp/atlas-Lymph_Node.png /tissue_expression/tmp/atlas-Thymus.png /tissue_expression/tmp/atlas-Salivary_Gland.png /tissue_expression/tmp/atlas-Bone_Marrow.png /tissue_expression/tmp/atlas-BM_CD34+.png /tissue_expression/tmp/atlas-Heart.png /tissue_expression/tmp/atlas-Skeletal_Muscle.png /tissue_expression/tmp/atlas-Kidney.png /tissue_expression/tmp/atlas-Liver.png /tissue_expression/tmp/atlas-Lung.png /tissue_expression/tmp/atlas-Pancreas.png /tissue_expression/tmp/atlas-Pancreatic_Islets.png /tissue_expression/tmp/atlas-Trachea.png /tissue_expression/tmp/atlas-Pituitary.png /tissue_expression/tmp/atlas-Thyroid.png /tissue_expression/tmp/atlas-Amygdala.png /tissue_expression/tmp/atlas-Caudate_Nucleus.png /tissue_expression/tmp/atlas-Cerebellum.png /tissue_expression/tmp/atlas-Hypothalamus.png /tissue_expression/tmp/atlas-Spinal_cord.png /tissue_expression/tmp/atlas-Thalamus.png /tissue_expression/tmp/atlas-Skin.png /tissue_expression/tmp/atlas-Ovary.png /tissue_expression/tmp/atlas-Placenta.png /tissue_expression/tmp/atlas-Prostate.png /tissue_expression/tmp/atlas-Testis.png /tissue_expression/tmp/atlas-Uterus.png
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 Expression Legend
 Range
0
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
100
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 No Data
Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.
  Interactions   Top   Help
  Interactions Table for MAPK13:
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
 
Interactor Interactor Sources Classification Pubmed IDs
MAPK13   PDIA6   IntAct, BioGRID  empirical  19135240 
MAPK13   G3BP1   IntAct, BioGRID  empirical  19135240 
MAPK13   TFG   IntAct, BioGRID  empirical  19135240 
MAPK13   CCT4   IntAct, BioGRID  empirical  19135240 
MAPK13   CCT2   IntAct, BioGRID  empirical  19135240 
MAPK13   PAICS   IntAct, BioGRID  empirical  19135240 
MAPK13   IGF2BP2   IntAct, BioGRID  empirical  19135240 
MAPK13   CCT8   IntAct, BioGRID  empirical  19135240 
MAPK13   NUDC   IntAct, BioGRID  empirical  19135240 
MAPK13   STIP1   IntAct, BioGRID  empirical  19135240 
MAPK13   CKB   IntAct, BioGRID  empirical  19135240 
MAPK13   CLTC   IntAct  empirical  19135240 
MAPK13   ATF2   HPRD, IntAct, BioGRID  empirical  9207191  19135240  12244047 
MAPK13   PARP1   IntAct, BioGRID  empirical  19135240 
MAPK13   DDX1   IntAct, BioGRID  empirical  19135240 
MAPK13   DDX3X   IntAct, BioGRID  empirical  19135240 
MAPK13   DHX9   IntAct, BioGRID  empirical  19135240 
MAPK13   AHCY   IntAct, BioGRID  empirical  19135240 
MAPK13   EEF1A1   IntAct, BioGRID  empirical  19135240 
MAPK13   EEF1B2   IntAct, BioGRID  empirical  19135240 
MAPK13   EEF1D   IntAct, BioGRID  empirical  19135240 
MAPK13   EEF2   IntAct, BioGRID  empirical  19135240 
MAPK13   EIF4A1   IntAct, BioGRID  empirical  19135240 
MAPK13   ENO1   IntAct, BioGRID  empirical  19135240 
MAPK13   EPRS   IntAct  empirical  19135240 
MAPK13   FASN   IntAct  empirical  19135240 
MAPK13   FGF12   BioGRID  empirical  12244047 
MAPK13   ALDOA   IntAct, BioGRID  empirical  19135240 
MAPK13   CCT5   IntAct, BioGRID  empirical  19135240 
MAPK13   ANKLE2   IntAct, BioGRID  empirical  18624398 
MAPK13   GANAB   IntAct, BioGRID  empirical  19135240 
MAPK13   MAPK8IP2   BioGRID  empirical  12244047  11378392 
MAPK13   FPR1   IntAct  empirical  22447027 
MAPK13   FUS   IntAct, BioGRID  empirical  19135240 
MAPK13   XRCC6   IntAct, BioGRID  empirical  19135240 
MAPK13   GAPDH   IntAct, BioGRID  empirical  19135240 
MAPK13   SERBP1   IntAct, BioGRID  empirical  19135240 
MAPK13   PHGDH   IntAct  empirical  19135240 
MAPK13   GDI2   IntAct, BioGRID  empirical  19135240 
MAPK13   PABPC1   IntAct, BioGRID  empirical  19135240 
MAPK13   CACYBP   IntAct, BioGRID  empirical  19135240 
MAPK13   HTRA2   BioGRID  empirical  17906618 
MAPK13   GPX4   IntAct, BioGRID  empirical  21988832 
MAPK13   PDIA3   IntAct, BioGRID  empirical  19135240 
MAPK13   EEF2K   HPRD  empirical  11500363  12171600 
MAPK13   HIST1H1C   IntAct, BioGRID  empirical  19135240 
MAPK13   HIST1H1E   IntAct, BioGRID  empirical  19135240 
MAPK13   HNRNPA1   IntAct, BioGRID  empirical  19135240 
MAPK13   HNRNPK   IntAct, BioGRID  empirical  19135240 
MAPK13   HSPA5   IntAct, BioGRID  empirical  19135240 
MAPK13   APP   BioGRID  empirical  21832049 
MAPK13   ILF3   IntAct  empirical  19135240 
MAPK13   ARF3   IntAct, BioGRID  empirical  19135240 
MAPK13   LDHA   IntAct, BioGRID  empirical  19135240 
MAPK13   LDHB   IntAct, BioGRID  empirical  19135240 
MAPK13   MARCKS   IntAct, BioGRID  empirical  19135240 
MAPK13   SMAD4   HPRD, MINT, IntAct, BioGRID  empirical  15231748 
MAPK13   MAPT   BioGRID  empirical  9199504 
MAPK13   MBP   HPRD, BioGRID  empirical  9207191  17906618 
MAPK13   MDH2   IntAct, BioGRID  empirical  19135240 
MAPK13   MAP3K4   HPRD  empirical  9841871 
MAPK13   NAP1L4   IntAct, BioGRID  empirical  19135240 
MAPK13   NASP   IntAct, BioGRID  empirical  19135240 
MAPK13   NCL   IntAct, BioGRID  empirical  19135240 
MAPK13   NONO   IntAct, BioGRID  empirical  19135240 
MAPK13   YBX1   IntAct, BioGRID  empirical  19135240 
MAPK13   ATP5A1   IntAct, BioGRID  empirical  19135240 
MAPK13   PFN1   IntAct, BioGRID  empirical  19135240 
MAPK13   PGAM1   IntAct, BioGRID  empirical  19135240 
MAPK13   PGK1   IntAct, BioGRID  empirical  19135240 
MAPK13   PKD1   BioGRID  empirical  19135240 
MAPK13   PKM   IntAct, BioGRID  empirical  19135240 
MAPK13   PLS3   IntAct, BioGRID  empirical  19135240 
MAPK13   PPA1   IntAct, BioGRID  empirical  19135240 
MAPK13   PRKD1   IntAct, BioGRID  empirical  19135240 
MAPK13   MAPK13   BioGRID  empirical  23602568 
MAPK13   MAP2K6   HPRD  empirical  9218798 
MAPK13   AKIP1   IntAct, BioGRID  empirical  18624398 
MAPK13   RAN   IntAct, BioGRID  empirical  19135240 
MAPK13   RPLP2   IntAct, BioGRID  empirical  19135240 
MAPK13   RPS3   IntAct, BioGRID  empirical  19135240 
MAPK13   RPS14   IntAct, BioGRID  empirical  19135240 
MAPK13   SFPQ   IntAct, BioGRID  empirical  19135240 
MAPK13   TMPO   IntAct, BioGRID  empirical  19135240 
MAPK13   HSP90B1   IntAct, BioGRID  empirical  19135240 
MAPK13   CCT3   IntAct, BioGRID  empirical  19135240 
MAPK13   UBC   BioGRID  empirical  21906983 
MAPK13   UBA1   IntAct, BioGRID  empirical  19135240 
MAPK13   VCP   BioGRID  empirical  23383273 
MAPK13   YWHAB   IntAct, BioGRID  empirical  19135240 
MAPK13   YWHAZ   IntAct, BioGRID  empirical  19135240 
MAPK13   MAPKAPK3   HPRD  empirical  9207191 
MAPK13   TAF15   IntAct, BioGRID  empirical  19135240 
MAPK13   CANX   IntAct, BioGRID  empirical  19135240 
MAPK13   TAGLN2   IntAct, BioGRID  empirical  19135240 
MAPK13   GFM1   IntAct, BioGRID  empirical  19135240 
MAPK13   MAPKAPK5   HPRD  empirical  9628874 
MAPK13   CBR1   IntAct, BioGRID  empirical  19135240 
MAPK13   IQGAP1   IntAct, BioGRID  empirical  19135240 
MAPK13   CCT6A   IntAct, BioGRID  empirical  19135240 
MAPK13   PRDX6   IntAct  empirical  19135240 
MAPK13   EIF5B   IntAct, BioGRID  empirical  19135240 
  Cross-Reference to Pathways and GO Terms   Top   Help
  KEGG Network: 21
Amyotrophic lateral sclerosis (ALS) Human - 5014 Mouse - 5014 Rat - 5014
Chagas disease (American trypanosomiasis) Human - 5142 Mouse - 5142 Rat - 5142
Epithelial cell signaling in Helicobacter pylori infection Human - 5120
Fc epsilon RI signaling pathway Human - 4664 Mouse - 4664 Rat - 4664
GnRH signaling pathway Human - 4912 Mouse - 4912 Rat - 4912
Hepatitis C Human - 5160 Mouse - 5160 Rat - 5160
Influenza A Human - 5164 Mouse - 5164 Rat - 5164
Leishmaniasis Human - 5140 Mouse - 5140 Rat - 5140
Leukocyte transendothelial migration Human - 4670 Mouse - 4670 Rat - 4670
MAPK signaling pathway Human - 4010 Mouse - 4010 Rat - 4010
Neurotrophin signaling pathway Human - 4722 Mouse - 4722 Rat - 4722
NOD-like receptor signaling pathway Human - 4621 Mouse - 4621 Rat - 4621
Osteoclast differentiation Human - 4380 Mouse - 4380 Rat - 4380
Progesterone-mediated oocyte maturation Human - 4914 Mouse - 4914 Rat - 4914
RIG-I-like receptor signaling pathway Human - 4622 Mouse - 4622 Rat - 4622
Shigellosis Human - 5131
T cell receptor signaling pathway Human - 4660 Mouse - 4660 Rat - 4660
Toll-like receptor signaling pathway Human - 4620 Mouse - 4620 Rat - 4620
Toxoplasmosis Human - 5145 Mouse - 5145 Rat - 5145
Tuberculosis Human - 5152 Mouse - 5152 Rat - 5152
VEGF signaling pathway Human - 4370 Mouse - 4370 Rat - 4370
  Biocarta: 3
Keratinocyte Differentiation
MAPKinase Signaling Pathway
Stathmin and breast cancer resistance to antimicrotubule agents
  Reactome: 12
Cell-Cell communicationREACT_111155
DSCAM interactionsREACT_33095
Immune SystemREACT_107772
Innate Immune SystemREACT_86987
NGF signalling via TRKA from the plasma membraneREACT_12056
NOD1/2 Signaling PathwayREACT_75776
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysREACT_109121
p38MAPK eventsREACT_79087
Signal TransductionREACT_111102
Signalling by NGFREACT_86675
Signalling to ERKsREACT_12058
Signalling to RASREACT_12033
  NCI-Nature Pathway Interaction Database: 1
  Gene Ontology: 17
MAPK cascade GO:0000165
Protein serine/threonine kinase activity GO:0004674
MAP kinase activity GO:0004707
Protein binding GO:0005515
ATP binding GO:0005524
Cytosol GO:0005829
Transcription, DNA-templated GO:0006351
Regulation of transcription, DNA-templated GO:0006355
Response to stress GO:0006950
Response to osmotic stress GO:0006970
Cell cycle GO:0007049
Ras protein signal transduction GO:0007265
Peptidyl-serine phosphorylation GO:0018105
Positive regulation of interleukin-6 production GO:0032755
Intracellular signal transduction GO:0035556
Neurotrophin TRK receptor signaling pathway GO:0048011
Positive regulation of inflammatory response GO:0050729
  Publications from PubMed   Top   Help
  Publication table for MAPK13
  Model Organism Phenotype Links from MGI   Top   Help
  Model Organism Phenotype Links: Available
  External Links   Top   Help
  Human Mouse Rat
Entrez Gene 5603 26415 29513
EnsEMBL Gene(s) ENSG00000156711 ENSMUSG00000004864 ENSRNOG00000000515
Unigene Hs.178695 Mm.27970 Rn.207195
Homologene MAPK13 Mapk13 Mapk13
OMIM 602899 N/A N/A
GeneCards MAPK13 N/A N/A
Beta Cell Genomicsinfo DT.100022242 DT.121396393 DT.75139262 DT.99970880 DT.490228 DT.97389875 N/A
Reactome O15264 Q9Z1B7 N/A
Plasma Peptide Atlasinfo N/A N/A N/A
WikiGenes 5603 26415 29513
GWAS Centralinfo MAPK13 N/A N/A