PRKDC

Summary Top Help

Gene Description:

protein kinase, DNA-activated, catalytic polypeptide; protein kinase, DNA activated, catalytic polypeptide

Synonyms:

XRCC7, AI326420, slip, AU019811, p460, DOXNPH, p350, DNAPDcs, DNPK1, PRKDC, HYRC, HYRC1, dxnph, DNA-PKcs, Prkdc, scid, DNAPK

Orthologs:

Human PRKDC (protein-coding), Mouse Prkdc (protein-coding), Rat Prkdc (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Iddm17	Rat	chr11:19445919..87759784	68.31	594

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr8:48685669..48872743 (1877 kb) View in Genome Browser

(Mouse) NCBIM37 - chr16:15637959..15842332 (204.37 kb) View in Genome Browser

(Rat) RGSC3.4 - chr11:86951420..87169229 (217.81 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PRKDC:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PRKDC:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 2

Biocarta: 4

Reactome: 4

NCI-Nature Pathway Interaction Database: 4

Gene Ontology: 38

Publications from PubMed Top Help

Type 1 Diabetes Publications: 66

IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction.
Westwell-Roper C, Dai DL, Soukhatcheva G, Potter KJ, van Rooijen N, Ehses JA, Verchere CB
J Immunol. 2011
PubMed ID: 21813778
Cardiovascular adaptations of pregnancy in T and B cell-deficient mice.
Burke SD, Barrette VF, Carter AL, Gravel J, Adams MA, Croy BA
Biol Reprod. 2011
PubMed ID: 21613629
mRNA of the pro-apoptotic gene BBC3 serves as a molecular marker for TNF-α-induced islet damage in humans.
Omori K, Mitsuhashi M, Ishiyama K, Nair I, Rawson J, Todorov I, Kandeel F, Mullen Y
Diabetologia. 2011
PubMed ID: 21567299
Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice.
Viret C, Leung-Theung-Long S, Serre L, Lamare C, Vignali DA, Malissen B, Carrier A, Guerder S
J Clin Invest. 2011
PubMed ID: 21505262
Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes.
Lee SM, Yang H, Tartar DM, Gao B, Luo X, Ye SQ, Zaghouani H, Fang D
Diabetologia. 2011
PubMed ID: 21340626
PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice.
Okazaki T, Okazaki IM, Wang J, Sugiura D, Nakaki F, Yoshida T, Kato Y, Fagarasan S, Muramatsu M, Eto T, Hioki K, Honjo T
J Exp Med. 2011
PubMed ID: 21300912
Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes.
Forbes JM, Söderlund J, Yap FY, Knip M, Andrikopoulos S, Ilonen J, Simell O, Veijola R, Sourris KC, Coughlan MT, Forsblom C, Slattery R, Grey ST, Wessman M, Yamamoto H, Bierhaus A, Cooper ME, Groop PH
Diabetologia. 2011
PubMed ID: 21298413
CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease.
Yang GX, Wu Y, Tsukamoto H, Leung PS, Lian ZX, Rainbow DB, Hunter KM, Morris GA, Lyons PA, Peterson LB, Wicker LS, Gershwin ME, Ridgway WM
J Immunol. 2011
PubMed ID: 21169553
mt-Nd2a modifies resistance against autoimmune Type 1 diabetes in NOD mice at the level of the pancreatic beta cell.
Chen J, Gusdon AM, Piganelli J, Leiter EH, Mathews CE
Diabetes. 2010
PubMed ID: 20980458
Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model.
Zhao Y, Guo C, Hwang D, Lin B, Dingeldein M, Mihailescu D, Sam S, Sidhwani S, Zhang Y, Jain S, Skidgel RA, Prabhakar BS, Mazzone T, Holterman MJ
Biochem Biophys Res Commun. 2010
PubMed ID: 20691153
Reversal of autoimmunity by boosting memory-like autoregulatory T cells.
Tsai S, Shameli A, Yamanouchi J, Clemente-Casares X, Wang J, Serra P, Yang Y, Medarova Z, Moore A, Santamaria P
Immunity. 2010
PubMed ID: 20381385
Pancreatic duodenal homeobox 1 protein is a novel beta-cell-specific autoantigen for type I diabetes.
Li SW, Koya V, Li Y, Donelan W, Lin P, Reeves WH, Yang LJ
Lab Invest. 2009
PubMed ID: 19901909
Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice.
Chou FC, Shieh SJ, Sytwu HK
Eur J Immunol. 2009
PubMed ID: 19670381
Natural killer cells modulate overt autoimmunity to homeostasis in nonobese diabetic mice after anti-CD3 F(ab')2 antibody treatment through secreting transforming growth factor-beta.
Chen G, Han G, Wang J, Wang R, Xu R, Shen B, Qian J, Li Y
Am J Pathol. 2009
PubMed ID: 19644014
Autoimmune thyroiditis in Fcgamma receptor-deficient nonobese diabetic mice.
Ozaki H, Mori K, Nakagawa Y, Hoshikawa S, Ito S, Inoue Y, Takai T, Yoshida K
Clin Immunol. 2009
PubMed ID: 19447681
Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice.
Mangada J, Pearson T, Brehm MA, Wicker LS, Peterson LB, Shultz LD, Serreze DV, Rossini AA, Greiner DL
Diabetes. 2008
PubMed ID: 18984741
Non-obese diabetic-recombination activating gene-1 (NOD-Rag 1(null) ) interleukin (IL)-2 receptor common gamma chain (IL 2 rgamma(null)) null mice: a radioresistant model for human lymphohaematopoietic engraftment.
Pearson T, Shultz LD, Miller D, King M, Laning J, Fodor W, Cuthbert A, Burzenski L, Gott B, Lyons B, Foreman O, Rossini AA, Greiner DL
Clin Exp Immunol. 2008
PubMed ID: 18785974
A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
Pearson T, Shultz LD, Lief J, Burzenski L, Gott B, Chase T, Foreman O, Rossini AA, Bottino R, Trucco M, Greiner DL
Diabetologia. 2008
PubMed ID: 18563383
Pathogenicity of T helper 2 T-cell clones from T-cell receptor transgenic non-obese diabetic mice is determined by tumour necrosis factor-alpha.
He J, Haskins K
Immunology. 2008
PubMed ID: 17983440
Specific inhibition of autoimmune T cell transmigration contributes to beta cell functionality and insulin synthesis in non-obese diabetic (NOD) mice.
Savinov AY, Rozanov DV, Strongin AY
J Biol Chem. 2007
PubMed ID: 17761671
An early age-related increase in the frequency of CD4+ Foxp3+ cells in BDC2.5NOD mice.
Thomas DC, Mellanby RJ, Phillips JM, Cooke A
Immunology. 2007
PubMed ID: 17437531
Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity.
Nakayama M, Beilke JN, Jasinski JM, Kobayashi M, Miao D, Li M, Coulombe MG, Liu E, Elliott JF, Gill RG, Eisenbarth GS
J Clin Invest. 2007
PubMed ID: 17607359
CD8+ T lymphocytes specific for glutamic acid decarboxylase 90-98 epitope mediate diabetes in NOD SCID mouse.
Sévère S, Gauvrit A, Vu AT, Bach JM
Mol Immunol. 2007
PubMed ID: 17336387
Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells.
Luo X, Tarbell KV, Yang H, Pothoven K, Bailey SL, Ding R, Steinman RM, Suthanthiran M
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17307871
In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model.
Calderon B, Suri A, Unanue ER
Am J Pathol. 2006
PubMed ID: 17148676
Glucocorticoid signalling affects pancreatic development through both direct and indirect effects.
Gesina E, Blondeau B, Milet A, Le Nin I, Duchene B, Czernichow P, Scharfmann R, Tronche F, Breant B
Diabetologia. 2006
PubMed ID: 17001468
Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice.
Perone MJ, Bertera S, Tawadrous ZS, Shufesky WJ, Piganelli JD, Baum LG, Trucco M, Morelli AE
J Immunol. 2006
PubMed ID: 17015713
Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways.
Dudek NL, Thomas HE, Mariana L, Sutherland RM, Allison J, Estella E, Angstetra E, Trapani JA, Santamaria P, Lew AM, Kay TW
Diabetes. 2006
PubMed ID: 16936188
Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes.
Chaparro RJ, Konigshofer Y, Beilhack GF, Shizuru JA, McDevitt HO, Chien YH
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16895987
Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells.
Battaglia M, Stabilini A, Draghici E, Migliavacca B, Gregori S, Bonifacio E, Roncarolo MG
Diabetes. 2006
PubMed ID: 16731819
The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells.
Waldner H, Sobel RA, Price N, Kuchroo VK
J Immunol. 2006
PubMed ID: 16622013
Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.
Chen J, Chen YG, Reifsnyder PC, Schott WH, Lee CH, Osborne M, Scheuplein F, Haag F, Koch-Nolte F, Serreze DV, Leiter EH
J Immunol. 2006
PubMed ID: 16585549
Regulation of the pancreatic duodenal homeobox-1 protein by DNA-dependent protein kinase.
Lebrun P, Montminy MR, Van Obberghen E
J Biol Chem. 2005
PubMed ID: 16166097
MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo.
Kupfer TM, Crawford ML, Pham K, Gill RG
J Immunol. 2005
PubMed ID: 16081800
The influence of the major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice.
Wong FS, Du W, Thomas IJ, Wen L
Diabetes. 2005
PubMed ID: 15983204
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
Jaeschke A, Rincón M, Doran B, Reilly J, Neuberg D, Greiner DL, Shultz LD, Rossini AA, Flavell RA, Davis RJ
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15867147
IFN beta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice.
Alba A, Puertas MC, Carrillo J, Planas R, Ampudia R, Pastor X, Bosch F, Pujol-Borrell R, Verdaguer J, Vives-Pi M
J Immunol. 2004
PubMed ID: 15557158
Deranged early T cell development in immunodeficient strains of nonobese diabetic mice.
Yui MA, Rothenberg EV
J Immunol. 2004
PubMed ID: 15494484
Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.
Banuelos SJ, Shultz LD, Greiner DL, Burzenski LM, Gott B, Lyons BL, Rossini AA, Appel MC
Clin Immunol. 2004
PubMed ID: 15308121
Early events in islets and pancreatic lymph nodes in autoimmune diabetes.
Aspord C, Rome S, Thivolet C
J Autoimmun. 2004
PubMed ID: 15236750
T-cell receptor transgenic response to an endogenous polymorphic autoantigen determines susceptibility to diabetes.
Pauza ME, Dobbs CM, He J, Patterson T, Wagner S, Anobile BS, Bradley BJ, Lo D, Haskins K
Diabetes. 2004
PubMed ID: 15047613
NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.
Shultz LD, Banuelos S, Lyons B, Samuels R, Burzenski L, Gott B, Lang P, Leif J, Appel M, Rossini A, Greiner DL
Transplantation. 2003
PubMed ID: 14557749
Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice.
Darwiche R, Chong MM, Santamaria P, Thomas HE, Kay TW
J Immunol. 2003
PubMed ID: 12794162
Adenovirus early region 3 antiapoptotic 10.4K, 14.5K, and 14.7K genes decrease the incidence of autoimmune diabetes in NOD mice.
Pierce MA, Chapman HD, Post CM, Svetlanov A, Efrat S, Horwitz M, Serreze DV
Diabetes. 2003
PubMed ID: 12716741
Contribution of Fas to diabetes development.
Savinov AY, Tcherepanov A, Green EA, Flavell RA, Chervonsky AV
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12525697
During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities.
DiLorenzo TP, Lieberman SM, Takaki T, Honda S, Chapman HD, Santamaria P, Serreze DV, Nathenson SG
Clin Immunol. 2002
PubMed ID: 12498815
Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice.
Marron MP, Graser RT, Chapman HD, Serreze DV
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12361980
Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells.
Hugues S, Mougneau E, Ferlin W, Jeske D, Hofman P, Homann D, Beaudoin L, Schrike C, Von Herrath M, Lehuen A, Glaichenhaus N
Immunity. 2002
PubMed ID: 11869679
Cutting edge: interactions through the IL-10 receptor regulate autoimmune diabetes.
Phillips JM, Parish NM, Drage M, Cooke A
J Immunol. 2001
PubMed ID: 11714766
Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool.
Serreze DV, Johnson EA, Chapman HD, Graser RT, Marron MP, DiLorenzo TP, Silveira P, Yoshimura Y, Nathenson SG, Joyce S
Diabetes. 2001
PubMed ID: 11522664
An accessory role of TCRgammadelta (+) cells in the exacerbation of inflammatory bowel disease in TCRalpha mutant mice.
Kawaguchi-Miyashita M, Shimada S, Kurosu H, Kato-Nagaoka N, Matsuoka Y, Ohwaki M, Ishikawa H, Nanno M
Eur J Immunol. 2001
PubMed ID: 11298322
A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetes.
Balasa B, La Cava A, Van Gunst K, Mocnik L, Balakrishna D, Nguyen N, Tucker L, Sarvetnick N
J Immunol. 2000
PubMed ID: 11120869
Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions.
Graser RT, DiLorenzo TP, Wang F, Christianson GJ, Chapman HD, Roopenian DC, Nathenson SG, Serreze DV
J Immunol. 2000
PubMed ID: 10725754
Significant role for Fas in the pathogenesis of autoimmune diabetes.
Su X, Hu Q, Kristan JM, Costa C, Shen Y, Gero D, Matis LA, Wang Y
J Immunol. 2000
PubMed ID: 10679090
Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice.
Amrani A, Verdaguer J, Anderson B, Utsugi T, Bou S, Santamaria P
J Clin Invest. 1999
PubMed ID: 10207172
Absolute requirement of macrophages for the development and activation of beta-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice.
Jun HS, Santamaria P, Lim HW, Zhang ML, Yoon JW
Diabetes. 1999
PubMed ID: 9892220
Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells.
Bridgett M, Cetkovic-Cvrlje M, O'Rourke R, Shi Y, Narayanswami S, Lambert J, Ramiya V, Baekkeskov S, Leiter EH
Diabetes. 1998
PubMed ID: 9836515
Beta-cell apoptosis in an accelerated model of autoimmune diabetes.
Augstein P, Stephens LA, Allison J, Elefanty AG, Ekberg M, Kay TW, Harrison LC
Mol Med. 1998
PubMed ID: 9742505
Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis.
Mähler M, Bristol IJ, Leiter EH, Workman AE, Birkenmeier EH, Elson CO, Sundberg JP
Am J Physiol. 1998
PubMed ID: 9530156
Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent.
Serreze DV, Chapman HD, Varnum DS, Gerling I, Leiter EH, Shultz LD
J Immunol. 1997
PubMed ID: 9103469
Acute graft rejection of human fetal pancreas allografts using donor-specific human peripheral blood lymphocytes in the SCID mouse.
MacKenzie DA, Sollinger HW, Hullett DA
Transplantation. 1996
PubMed ID: 8633371
Retention of endocrine function in the SCID-Hu pancreas mouse--a model for the development of human fetal islet tissue.
Goldrath AW, Chen KE, Weide LG, Pour PM, Lebkowski JS, Alters SE
Transplantation. 1995
PubMed ID: 7770944
Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.
Shultz LD, Schweitzer PA, Christianson SW, Gott B, Schweitzer IB, Tennent B, McKenna S, Mobraaten L, Rajan TV, Greiner DL
J Immunol. 1995
PubMed ID: 7995938
How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model.
von Herrath MG, Dockter J, Oldstone MB
Immunity. 1994
PubMed ID: 7889411
The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.
Prochazka M, Gaskins HR, Shultz LD, Leiter EH
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1373493
Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice.
Leiter EH, Prochazka M, Shultz LD
J Immunol. 1987
PubMed ID: 3553324

Publications: 879

Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.
Takagi S, Saito Y, Hijikata A, Tanaka S, Watanabe T, Hasegawa T, Mochizuki S, Kunisawa J, Kiyono H, Koseki H, Ohara O, Saito T, Taniguchi S, Shultz LD, Ishikawa F
Blood. 2012
PubMed ID: 22279057
Engraftment of human HSC in non-irradiated newborn NOD-scid IL2rγnull mice is enhanced by transgenic expression of membrane-bound human SCF.
Brehm MA, Racki WJ, Leif J, Burzenski L, Hosur V, Wetmore A, Gott B, Herlihy M, Ignotz R, Dunn R, Shultz LD, Greiner DL
Blood. 2012
PubMed ID: 22246028
HIV latency in the humanized BLT mouse.
Marsden MD, Kovochich M, Suree N, Shimizu S, Mehta R, Cortado R, Bristol G, An DS, Zack JA
J Virol. 2012
PubMed ID: 22072769
Oncogene-targeting T cells reject large tumors while oncogene inactivation selects escape variants in mouse models of cancer.
Anders K, Buschow C, Herrmann A, Milojkovic A, Loddenkemper C, Kammertoens T, Daniel P, Yu H, Charo J, Blankenstein T
Cancer Cell. 2011
PubMed ID: 22172721
Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context.
Gunn A, Bennardo N, Cheng A, Stark JM
J Biol Chem. 2011
PubMed ID: 22027841
Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
Macrophages prevent human red blood cell reconstitution in immunodeficient mice.
Hu Z, Van Rooijen N, Yang YG
Blood. 2011
PubMed ID: 21926352
Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum.
Tanori M, Pasquali E, Leonardi S, Giardullo P, Di Majo V, Taccioli G, Essers J, Kanaar R, Mullenders LH, Atkinson MJ, Mancuso M, Saran A, Pazzaglia S
Oncogene. 2011
PubMed ID: 21602895
Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice.
Sela U, Olds P, Park A, Schlesinger SJ, Steinman RM
J Exp Med. 2011
PubMed ID: 22084406
Telomere protection by TPP1/POT1 requires tethering to TIN2.
Takai KK, Kibe T, Donigian JR, Frescas D, de Lange T
Mol Cell. 2011
PubMed ID: 22099311
Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo.
Baerenwaldt A, Lux A, Danzer H, Spriewald BM, Ullrich E, Heidkamp G, Dudziak D, Nimmerjahn F
Proc Natl Acad Sci U S A. 2011
PubMed ID: 22065769
Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rγ(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease.
Covassin L, Laning J, Abdi R, Langevin DL, Phillips NE, Shultz LD, Brehm MA
Clin Exp Immunol. 2011
PubMed ID: 21985373
Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair.
Malewicz M, Kadkhodaei B, Kee N, Volakakis N, Hellman U, Viktorsson K, Leung CY, Chen B, Lewensohn R, van Gent DC, Chen DJ, Perlmann T
Genes Dev. 2011
PubMed ID: 21979916
ORAI1 deficiency impairs activated T cell death and enhances T cell survival.
Kim KD, Srikanth S, Yee MK, Mock DC, Lawson GW, Gwack Y
J Immunol. 2011
PubMed ID: 21873530
Course of infection with the emergent pathogen Brucella microti in immunocompromised mice.
Jiménez de Bagüés MP, de Martino A, Quintana JF, Alcaraz A, Pardo J
Infect Immun. 2011
PubMed ID: 21825066
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.
Viatour P, Ehmer U, Saddic LA, Dorrell C, Andersen JB, Lin C, Zmoos AF, Mazur PK, Schaffer BE, Ostermeier A, Vogel H, Sylvester KG, Thorgeirsson SS, Grompe M, Sage J
J Exp Med. 2011
PubMed ID: 21875955
Asymmetry-defective oligodendrocyte progenitors are glioma precursors.
Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C
Cancer Cell. 2011
PubMed ID: 21907924
Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.
Berndt JD, Aoyagi A, Yang P, Anastas JN, Tang L, Moon RT
J Cell Biol. 2011
PubMed ID: 21875946
GPR56 Regulates VEGF production and angiogenesis during melanoma progression.
Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A, Begum S, Hynes RO, Xu L
Cancer Res. 2011
PubMed ID: 21724588
Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host.
Xu W, Xin L, Soong L, Zhang K
Infect Immun. 2011
PubMed ID: 21576322
Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.
Bandeira M, Santos CS, de Azevedo EC, Soares LM, Macedo JO, Marchi S, da Silva CL, Chagas-Junior AD, McBride AJ, McBride FW, Reis MG, Athanazio DA
Infect Immun. 2011
PubMed ID: 21576342
Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice.
Lou YR, Peng QY, Li T, Medvecky CM, Lin Y, Shih WJ, Conney AH, Shapses S, Wagner GC, Lu YP
Carcinogenesis. 2011
PubMed ID: 21525235
DNA-dependent protein kinase interacts functionally with the RNA polymerase II complex recruited at the human immunodeficiency virus (HIV) long terminal repeat and plays an important role in HIV gene expression.
Tyagi S, Ochem A, Tyagi M
J Gen Virol. 2011
PubMed ID: 21450944
The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.
Kemp MG, Lindsey-Boltz LA, Sancar A
J Biol Chem. 2011
PubMed ID: 21487018
A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia.
Bouquet F, Ousset M, Biard D, Fallone F, Dauvillier S, Frit P, Salles B, Muller C
J Cell Sci. 2011
PubMed ID: 21576354
Human T cell development in the liver of humanized NOD/SCID/IL-2Rγ(null)(NSG) mice generated by intrahepatic injection of CD34(+) human (h) cord blood (CB) cells.
Choi B, Chun E, Kim M, Kim SY, Kim ST, Yoon K, Lee KY, Kim SJ
Clin Immunol. 2011
PubMed ID: 21429805
PIDD orchestrates translesion DNA synthesis in response to UV irradiation.
Logette E, Schuepbach-Mallepell S, Eckert MJ, Leo XH, Jaccard B, Manzl C, Tardivel A, Villunger A, Quadroni M, Gaide O, Tschopp J
Cell Death Differ. 2011
PubMed ID: 21415862
The association of DNA-dependent protein kinase activity of peripheral blood lymphocytes with prognosis of cancer.
Someya M, Sakata KI, Matsumoto Y, Kamdar RP, Kai M, Toyota M, Hareyama M
Br J Cancer. 2011
PubMed ID: 21559021
PTEN deletion and heme oxygenase-1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcome.
Li Y, Su J, DingZhang X, Zhang J, Yoshimoto M, Liu S, Bijian K, Gupta A, Squire JA, Alaoui Jamali MA, Bismar TA
J Pathol. 2011
PubMed ID: 21381033
The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells.
Barroso-delJesus A, Lucena-Aguilar G, Sanchez L, Ligero G, Gutierrez-Aranda I, Menendez P
FASEB J. 2011
PubMed ID: 21266536
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair.
Zhang S, Yajima H, Huynh H, Zheng J, Callen E, Chen HT, Wong N, Bunting S, Lin YF, Li M, Lee KJ, Story M, Gapud E, Sleckman BP, Nussenzweig A, Zhang CC, Chen DJ, Chen BP
J Cell Biol. 2011
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Involvement of DNA-dependent protein kinase in normal cell cycle progression through mitosis.
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J Biol Chem. 2011
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Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation.
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Mol Cell Biol. 2011
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Murine Prkdc polymorphisms impact DNA-PKcs function.
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Radiat Res. 2011
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An analysis of CAF-1-interacting proteins reveals dynamic and direct interactions with the KU complex and 14-3-3 proteins.
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J Biol Chem. 2011
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Functional complementation between FADD and RIP1 in embryos and lymphocytes.
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Nature. 2011
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The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma.
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Cancer Cell. 2011
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Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm.
Wang P, Rodriguez RT, Wang J, Ghodasara A, Kim SK
Cell Stem Cell. 2011
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The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.
Hasegawa M, Kawai K, Mitsui T, Taniguchi K, Monnai M, Wakui M, Ito M, Suematsu M, Peltz G, Nakamura M, Suemizu H
Biochem Biophys Res Commun. 2011
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Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts.
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Int Immunol. 2011
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Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.
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Proc Natl Acad Sci U S A. 2011
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Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.
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Proc Natl Acad Sci U S A. 2011
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Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
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Mol Cell Proteomics. 2011
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Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagy.
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Brain Res. 2011
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Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages.
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PLoS One. 2011
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Gene expression associated with DNA-dependent protein kinase activity under normoxia, hypoxia, and reoxygenation.
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J Radiat Res (Tokyo). 2011
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DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange.
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PLoS One. 2011
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Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin.
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Mol Cancer. 2011
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
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Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy.
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Am J Pathol. 2011
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Strand-specific PCR of UV radiation-damaged genomic DNA revealed an essential role of DNA-PKcs in the transcription-coupled repair.
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BMC Biochem. 2011
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Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection.
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Eur J Immunol. 2011
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Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability.
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Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity.
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Leukemia. 2011
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Phosphorylation of p50 NF-kappaB at a single serine residue by DNA-dependent protein kinase is critical for VCAM-1 expression upon TNF treatment.
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J Biol Chem. 2010
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Dual functional monoclonal antibody PF-04605412 targets integrin alpha5beta1 and elicits potent antibody-dependent cellular cytotoxicity.
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Cancer Res. 2010
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Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation.
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Cell Stem Cell. 2010
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Low expression of Ku70/80, but high expression of DNA-PKcs, predict good response to radiotherapy in early breast cancer.
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Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population.
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Oncogene. 2010
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Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence.
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Blood. 2010
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Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells.
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Oncogene. 2010
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Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice.
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GAPDH mediates nitrosylation of nuclear proteins.
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Nat Cell Biol. 2010
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Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies.
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Polymorphic variants of DNA repair gene XRCC3 and XRCC7 and risk of prostate cancer: a study from North Indian population.
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DNA Cell Biol. 2010
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DNA-PK promotes the survival of young neurons in the embryonic mouse retina.
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Cell Death Differ. 2010
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Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells.
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Blood. 2010
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MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3.
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Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited.
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Cancer Res. 2010
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Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.
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Aging (Albany NY). 2010
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A human MAP kinase interactome.
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Nat Methods. 2010
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DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis.
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EMBO Mol Med. 2010
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Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.
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Carcinogenesis. 2010
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Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice.
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Blood. 2010
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Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.
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Proc Natl Acad Sci U S A. 2010
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Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.
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Nature. 2010
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Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.
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Genes Dev. 2010
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Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway.
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Cancer Res. 2010
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Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.
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Proc Natl Acad Sci U S A. 2010
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Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells.
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Science. 2010
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Leukemia regression by vascular disruption and antiangiogenic therapy.
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Blood. 2010
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Long-term human CD34+ stem cell-engrafted nonobese diabetic/SCID/IL-2R gamma(null) mice show impaired CD8+ T cell maintenance and a functional arrest of immature NK cells.
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J Immunol. 2010
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Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.
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Proc Natl Acad Sci U S A. 2010
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CD62L expression identifies a unique subset of polyfunctional CD56dim NK cells.
Juelke K, Killig M, Luetke-Eversloh M, Parente E, Gruen J, Morandi B, Ferlazzo G, Thiel A, Schmitt-Knosalla I, Romagnani C
Blood. 2010
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Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
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FEBS J. 2010
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Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo.
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Nat Biotechnol. 2010
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Identification of a cell of origin for human prostate cancer.
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Science. 2010
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Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15.
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Blood. 2010
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BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery.
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J Neurosci. 2010
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Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice.
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Proc Natl Acad Sci U S A. 2010
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Variation within DNA repair pathway genes and risk of multiple sclerosis.
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Am J Epidemiol. 2010
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Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis.
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Mol Biol Cell. 2010
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Comparison of human cord blood engraftment between immunocompromised mouse strains.
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Blood. 2010
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Network organization of the human autophagy system.
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Nature. 2010
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Regulatory functions of TRAIL in hematopoietic progenitors: human umbilical cord blood and murine bone marrow transplantation.
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Leukemia. 2010
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MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.
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Mol Cell Biol. 2010
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Tracking the rejection and survival of mouse ovarian iso- and allografts in vivo with bioluminescent imaging.
Chen CH, Yeh YC, Wu GJ, Huang YH, Lai WF, Liu JY, Tzeng CR
Reproduction. 2010
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Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
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Mol Med. 2010
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Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.
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J Biol Chem. 2010
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Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation.
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Blood. 2010
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The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.
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Genes Dev. 2010
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CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.
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J Immunol. 2010
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Phosphorylation of histone H2A.X by DNA-dependent protein kinase is not affected by core histone acetylation, but it alters nucleosome stability and histone H1 binding.
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An immunocompromised murine model of chronic Bartonella infection.
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Am J Pathol. 2010
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Type-I IFN signaling suppresses an excessive IFN-gamma response and thus prevents lung damage and chronic inflammation during pneumocystis (PC) clearance in CD4 T cell-competent mice.
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Am J Pathol. 2010
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Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation.
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Nucleic Acids Res. 2010
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BCR/ABL downregulates DNA-PK(CS)-dependent and upregulates backup non-homologous end joining in leukemic cells.
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Mol Biol Rep. 2010
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Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.
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Breast Cancer Res Treat. 2010
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Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate.
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Cancer Cell. 2010
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Regulation of learning and memory by meningeal immunity: a key role for IL-4.
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J Exp Med. 2010
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NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors.
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PLoS Pathog. 2010
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Radiation-induced survivin nuclear accumulation is linked to DNA damage repair.
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Int J Radiat Oncol Biol Phys. 2010
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Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.
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Mol Cell Biol. 2010
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Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alpha.
Medunjanin S, Weinert S, Schmeisser A, Mayer D, Braun-Dullaeus RC
Mol Biol Cell. 2010
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Systematic analysis of human protein complexes identifies chromosome segregation proteins.
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Science. 2010
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Plk4 is required for cytokinesis and maintenance of chromosomal stability.
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Proc Natl Acad Sci U S A. 2010
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An Oct4-centered protein interaction network in embryonic stem cells.
van den Berg DL, Snoek T, Mullin NP, Yates A, Bezstarosti K, Demmers J, Chambers I, Poot RA
Cell Stem Cell. 2010
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Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities.
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Oncol Rep. 2010
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Lymphocyte responses exacerbate angiotensin II-dependent hypertension.
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Am J Physiol Regul Integr Comp Physiol. 2010
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Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice.
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Blood. 2010
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Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells.
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Blood. 2010
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Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells.
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Cell Stem Cell. 2010
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Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha.
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EMBO Rep. 2010
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Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.
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Mol Cell Biol. 2010
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Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes.
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Leukemia. 2010
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Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells.
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J Immunol. 2010
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Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.
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Cancer Res. 2010
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Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor.
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Nat Med. 2010
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Immune effectors required for hepatitis B virus clearance.
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Proc Natl Acad Sci U S A. 2010
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Aire's partners in the molecular control of immunological tolerance.
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Cell. 2010
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Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
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Nature. 2010
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The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice.
Rauch DA, Hurchla MA, Harding JC, Deng H, Shea LK, Eagleton MC, Niewiesk S, Lairmore MD, Piwnica-Worms D, Rosol TJ, Weber JD, Ratner L, Weilbaecher KN
PLoS One. 2010
PubMed ID: 21209895
The effect of DNA-dependent protein kinase on adeno-associated virus replication.
Choi YK, Nash K, Byrne BJ, Muzyczka N, Song S
PLoS One. 2010
PubMed ID: 21188139
Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation.
Yan D, Ng WL, Zhang X, Wang P, Zhang Z, Mo YY, Mao H, Hao C, Olson JJ, Curran WJ, Wang Y
PLoS One. 2010
PubMed ID: 20617180
DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression.
An J, Huang YC, Xu QZ, Zhou LJ, Shang ZF, Huang B, Wang Y, Liu XD, Wu DC, Zhou PK
BMC Mol Biol. 2010
PubMed ID: 20205745
Site and strain-specific variation in gut microbiota profiles and metabolism in experimental mice.
Friswell MK, Gika H, Stratford IJ, Theodoridis G, Telfer B, Wilson ID, McBain AJ
PLoS One. 2010
PubMed ID: 20052418
Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo.
Ebrahem Q, Chaurasia SS, Vasanji A, Qi JH, Klenotic PA, Cutler A, Asosingh K, Erzurum S, Anand-Apte B
Am J Pathol. 2010
PubMed ID: 19948826
Suppression of DNA-PKcs enhances FGF-2 dependent human endothelial cell proliferation via negative regulation of Akt.
Mannell H, Hammitzsch A, Mettler R, Pohl U, Krötz F
Cell Signal. 2010
PubMed ID: 19781633
Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression.
Ohno M, Kunimoto M, Nishizuka M, Osada S, Imagawa M
Biochem Biophys Res Commun. 2009
PubMed ID: 19833092
Division and apoptosis of E2f-deficient retinal progenitors.
Chen D, Pacal M, Wenzel P, Knoepfler PS, Leone G, Bremner R
Nature. 2009
PubMed ID: 20016601
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.
Das BB, Antony S, Gupta S, Dexheimer TS, Redon CE, Garfield S, Shiloh Y, Pommier Y
EMBO J. 2009
PubMed ID: 19851285
Synovial fibroblasts spread rheumatoid arthritis to unaffected joints.
Lefèvre S, Knedla A, Tennie C, Kampmann A, Wunrau C, Dinser R, Korb A, Schnäker EM, Tarner IH, Robbins PD, Evans CH, Stürz H, Steinmeyer J, Gay S, Schölmerich J, Pap T, Müller-Ladner U, Neumann E
Nat Med. 2009
PubMed ID: 19898488
Complement receptor 3 deficiency influences lesion progression during Leishmania major infection in BALB/c mice.
Carter CR, Whitcomb JP, Campbell JA, Mukbel RM, McDowell MA
Infect Immun. 2009
PubMed ID: 19797068
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q
Occup Environ Med. 2009
PubMed ID: 19773279
The DNA-PK catalytic subunit regulates Bax-mediated excitotoxic cell death by Ku70 phosphorylation.
Liu J, Naegele JR, Lin SL
Brain Res. 2009
PubMed ID: 19664609
Do DNA repair genes OGG1, XRCC3 and XRCC7 have an impact on susceptibility to bladder cancer in the North Indian population?
Gangwar R, Ahirwar D, Mandhani A, Mittal RD
Mutat Res. 2009
PubMed ID: 19815090
A mouse model of inducible liver injury caused by tet-on regulated urokinase for studies of hepatocyte transplantation.
Song X, Guo Y, Duo S, Che J, Wu C, Ochiya T, Ding M, Deng H
Am J Pathol. 2009
PubMed ID: 19808649
ADAR1 is required for hematopoietic progenitor cell survival via RNA editing.
XuFeng R, Boyer MJ, Shen H, Li Y, Yu H, Gao Y, Yang Q, Wang Q, Cheng T
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19805087
Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.
Matafora V, D'Amato A, Mori S, Blasi F, Bachi A
Mol Cell Proteomics. 2009
PubMed ID: 19596686
Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses.
Seif AE, Barrett DM, Milone M, Brown VI, Grupp SA, Reid GS
Blood. 2009
PubMed ID: 19636062
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.
Ahel D, Horejsí Z, Wiechens N, Polo SE, Garcia-Wilson E, Ahel I, Flynn H, Skehel M, West SC, Jackson SP, Owen-Hughes T, Boulton SJ
Science. 2009
PubMed ID: 19661379
Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86.
Beskow C, Skikuniene J, Holgersson A, Nilsson B, Lewensohn R, Kanter L, Viktorsson K
Br J Cancer. 2009
PubMed ID: 19672258
Humanized mice show clinical signs of dengue fever according to infecting virus genotype.
Mota J, Rico-Hesse R
J Virol. 2009
PubMed ID: 19535452
Hepatitis C virus-core protein facilitates the degradation of Ku70 and reduces DNA-PK activity in hepatocytes.
Saitou K, Mizumoto K, Nishimura T, Kai C, Tsukiyama-Kohara K
Virus Res. 2009
PubMed ID: 19467273
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.
Gottschalk AJ, Timinszky G, Kong SE, Jin J, Cai Y, Swanson SK, Washburn MP, Florens L, Ladurner AG, Conaway JW, Conaway RC
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19666485
Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design.
VanBuskirk KM, O'Neill MT, De La Vega P, Maier AG, Krzych U, Williams J, Dowler MG, Sacci JB, Kangwanrangsan N, Tsuboi T, Kneteman NM, Heppner DG, Murdock BA, Mikolajczak SA, Aly AS, Cowman AF, Kappe SH
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19625622
The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells.
Liu D, Zhang T, Marshall AJ, Okkenhaug K, Vanhaesebroeck B, Uzonna JE
J Immunol. 2009
PubMed ID: 19596993
Common genetic variants in candidate genes and risk of familial lymphoid malignancies.
Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR
Br J Haematol. 2009
PubMed ID: 19573080
Enhanced generation of hematopoietic cells from human hepatocarcinoma cell-stimulated human embryonic and induced pluripotent stem cells.
Lu M, Kardel MD, O'Connor MD, Eaves CJ
Exp Hematol. 2009
PubMed ID: 19481135
Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.
Unsinger J, McDonough JS, Shultz LD, Ferguson TA, Hotchkiss RS
J Leukoc Biol. 2009
PubMed ID: 19369639
A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70.
Hasegawa M, Kurata M, Yamamoto K, Yoshida K, Aizawa S, Kitagawa M
Leuk Res. 2009
PubMed ID: 19058849
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
Sfeir A, Kosiyatrakul ST, Hockemeyer D, MacRae SL, Karlseder J, Schildkraut CL, de Lange T
Cell. 2009
PubMed ID: 19596237
Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.
King MA, Covassin L, Brehm MA, Racki W, Pearson T, Leif J, Laning J, Fodor W, Foreman O, Burzenski L, Chase TH, Gott B, Rossini AA, Bortell R, Shultz LD, Greiner DL
Clin Exp Immunol. 2009
PubMed ID: 19659776
[Correlation of DNA-dependent protein kinase catalytic subunit expression to radiosensitivity of non-small cell lung cancer cell lines].
Pan Y, Li WX, Li JM, Zhu JQ, Liang YQ, Guo AL
Ai Zheng. 2009
PubMed ID: 19624897
Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.
Tomimatsu N, Mukherjee B, Burma S
EMBO Rep. 2009
PubMed ID: 19444312
Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation.
Hoggatt J, Singh P, Sampath J, Pelus LM
Blood. 2009
PubMed ID: 19324903
Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.
Powley IR, Kondrashov A, Young LA, Dobbyn HC, Hill K, Cannell IG, Stoneley M, Kong YW, Cotes JA, Smith GC, Wek R, Hayes C, Gant TW, Spriggs KA, Bushell M, Willis AE
Genes Dev. 2009
PubMed ID: 19451221
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.
Callén E, Jankovic M, Wong N, Zha S, Chen HT, Difilippantonio S, Di Virgilio M, Heidkamp G, Alt FW, Nussenzweig A, Nussenzweig M
Mol Cell. 2009
PubMed ID: 19450527
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Significance of phosphatase and tensin homologue (PTEN), O(6)-methylguanine-DNA methyltransferase (MGMT), and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein expression in gynaecomastia.
Zhu L, Liu Z, Yang J, Cai J
J Int Med Res. 2009
PubMed ID: 19589246
Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells.
Bao L, Haas M, Pippin J, Wang Y, Miwa T, Chang A, Minto AW, Petkova M, Qiao G, Song WC, Alpers CE, Zhang J, Shankland SJ, Quigg RJ
J Clin Invest. 2009
PubMed ID: 19349693
Altered dendritic cell phenotype in response to Leishmania amazonensis amastigote infection is mediated by MAP kinase, ERK.
Boggiatto PM, Jie F, Ghosh M, Gibson-Corley KN, Ramer-Tait AE, Jones DE, Petersen CA
Am J Pathol. 2009
PubMed ID: 19349356
MRE11 complex links RECQ5 helicase to sites of DNA damage.
Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori AA, Gerrits B, Shevelev I, Janscak P
Nucleic Acids Res. 2009
PubMed ID: 19270065
Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice.
Boldizsar F, Tarjanyi O, Nemeth P, Mikecz K, Glant TT
Int Immunol. 2009
PubMed ID: 19254958
Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.
Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Méjean A, Desgrandchamps F, Lathrop M, Sarasin A, Benhamou S
Carcinogenesis. 2009
PubMed ID: 19237606
ALK mutants in the kinase domain exhibit altered kinase activity and differential sensitivity to small molecule ALK inhibitors.
Lu L, Ghose AK, Quail MR, Albom MS, Durkin JT, Holskin BP, Angeles TS, Meyer SL, Ruggeri BA, Cheng M
Biochemistry. 2009
PubMed ID: 19249873
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.
Ouyang J, Shi Y, Valin A, Xuan Y, Gill G
Mol Cell. 2009
PubMed ID: 19394292
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.
Deriano L, Stracker TH, Baker A, Petrini JH, Roth DB
Mol Cell. 2009
PubMed ID: 19362533
Tumours with PI3K activation are resistant to dietary restriction.
Kalaany NY, Sabatini DM
Nature. 2009
PubMed ID: 19279572
hnRNP-U is a specific DNA-dependent protein kinase substrate phosphorylated in response to DNA double-strand breaks.
Berglund FM, Clarke PR
Biochem Biophys Res Commun. 2009
PubMed ID: 19351595
Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation.
Hossain MB, Ji P, Anish R, Jacobson RH, Takada S
J Biol Chem. 2009
PubMed ID: 19181665
A role of DNA-PK for the metabolic gene regulation in response to insulin.
Wong RH, Chang I, Hudak CS, Hyun S, Kwan HY, Sul HS
Cell. 2009
PubMed ID: 19303849
Recognition of live phosphatidylserine-labeled tumor cells by dendritic cells: a novel approach to immunotherapy of skin cancer.
Shurin MR, Potapovich AI, Tyurina YY, Tourkova IL, Shurin GV, Kagan VE
Cancer Res. 2009
PubMed ID: 19276376
DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif.
Park J, Feng J, Li Y, Hammarsten O, Brazil DP, Hemmings BA
J Biol Chem. 2009
PubMed ID: 19144640
Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9.
Wang Y, Sul HS
Cell Metab. 2009
PubMed ID: 19254573
DNA repair-deficient Xpa/p53 knockout mice are sensitive to the non-genotoxic carcinogen cyclosporine A: escape of initiated cells from immunosurveillance?
van Kesteren PC, Beems RB, Luijten M, Robinson J, de Vries A, van Steeg H
Carcinogenesis. 2009
PubMed ID: 19136475
CD40/CD40L contributes to hypercholesterolemia-induced microvascular inflammation.
Stokes KY, Calahan L, Hamric CM, Russell JM, Granger DN
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19112095
Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.
Read TA, Fogarty MP, Markant SL, McLendon RE, Wei Z, Ellison DW, Febbo PG, Wechsler-Reya RJ
Cancer Cell. 2009
PubMed ID: 19185848
Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation.
Morris SC, Heidorn SM, Herbert DR, Perkins C, Hildeman DA, Khodoun MV, Finkelman FD
J Immunol. 2009
PubMed ID: 19155490
DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases.
Yajima H, Lee KJ, Zhang S, Kobayashi J, Chen BP
J Mol Biol. 2009
PubMed ID: 19071136
Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice.
Tsuji H, Ishii-Ohba H, Noda Y, Kubo E, Furuse T, Tatsumi K
Mutat Res. 2009
PubMed ID: 19000702
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.
McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, Gozani O, Burlingame AL, Bohr VA, Chua KF
Aging (Albany NY). 2009
PubMed ID: 20157594
DNA double strand break repair enzymes function at multiple steps in retroviral infection.
Sakurai Y, Komatsu K, Agematsu K, Matsuoka M
Retrovirology. 2009
PubMed ID: 20003485
Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.
Jaiswal S, Pearson T, Friberg H, Shultz LD, Greiner DL, Rothman AL, Mathew A
PLoS One. 2009
PubMed ID: 19802382
Complexes of DNA-dependent protein kinase with single-stranded oligo-(AGGG)6: identification and possible role in modulation of ribosomal RNA transcription.
Netchvolodov KK, Kurova VS, Kononikhin AS, Savochkina YA, Nikolaevb EN, Kupriyanova NS, Ryskov AP, Varfolomeev SD
Dokl Biochem Biophys. 2009
PubMed ID: 19341095
Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6.
Mi J, Dziegielewski J, Bolesta E, Brautigan DL, Larner JM
PLoS One. 2009
PubMed ID: 19198648
Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice.
Elahi E, Suraweera N, Volikos E, Haines J, Brown N, Davidson G, Churchman M, Ilyas M, Tomlinson I, Silver A
PLoS One. 2009
PubMed ID: 19194513
A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining.
van der Burg M, Ijspeert H, Verkaik NS, Turul T, Wiegant WW, Morotomi-Yano K, Mari PO, Tezcan I, Chen DJ, Zdzienicka MZ, van Dongen JJ, van Gent DC
J Clin Invest. 2009
PubMed ID: 19075392
DNA-PK suppresses a p53-independent apoptotic response to DNA damage.
Gurley KE, Moser R, Gu Y, Hasty P, Kemp CJ
EMBO Rep. 2009
PubMed ID: 19057578
Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.
Stracker TH, Williams BR, Deriano L, Theunissen JW, Adelman CA, Roth DB, Petrini JH
Mol Cell Biol. 2009
PubMed ID: 19015239
Brain trauma enhances transient cytomegalovirus invasion of the brain only in mice that are immunodeficient.
van den Pol AN
J Virol. 2009
PubMed ID: 18945784
HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase.
Durkin SS, Guo X, Fryrear KA, Mihaylova VT, Gupta SK, Belgnaoui SM, Haoudi A, Kupfer GM, Semmes OJ
J Biol Chem. 2008
PubMed ID: 18957425
Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Enjuanes A, Benavente Y, Bosch F, Martín-Guerrero I, Colomer D, Pérez-Alvarez S, Reina O, Ardanaz MT, Jares P, García-Orad A, Pujana MA, Montserrat E, de Sanjosé S, Campo E
Cancer Res. 2008
PubMed ID: 19074885
Efficient tumour formation by single human melanoma cells.
Quintana E, Shackleton M, Sabel MS, Fullen DR, Johnson TM, Morrison SJ
Nature. 2008
PubMed ID: 19052619
DNA-dependent protein kinase is involved in heat shock protein-mediated accumulation of hypoxia-inducible factor-1alpha in hypoxic preconditioned HepG2 cells.
Kang MJ, Jung SM, Kim MJ, Bae JH, Kim HB, Kim JY, Park SJ, Song HS, Kim DW, Kang CD, Kim SH
FEBS J. 2008
PubMed ID: 19021771
The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair.
Alfaro MP, Pagni M, Vincent A, Atkinson J, Hill MF, Cates J, Davidson JM, Rottman J, Lee E, Young PP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19017790
Tissue-specific DNA-PK-dependent H2AX phosphorylation and gamma-H2AX elimination after X-irradiation in vivo.
Koike M, Sugasawa J, Yasuda M, Koike A
Biochem Biophys Res Commun. 2008
PubMed ID: 18755145
Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains.
Agliano A, Martin-Padura I, Mancuso P, Marighetti P, Rabascio C, Pruneri G, Shultz LD, Bertolini F
Int J Cancer. 2008
PubMed ID: 18688847
In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.
Surucu B, Bozulic L, Hynx D, Parcellier A, Hemmings BA
J Biol Chem. 2008
PubMed ID: 18757368
Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells.
Notley CA, Inglis JJ, Alzabin S, McCann FE, McNamee KE, Williams RO
J Exp Med. 2008
PubMed ID: 18936235
Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: A two-stage Spanish case-control study.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A
Gynecol Oncol. 2008
PubMed ID: 18950845
RAD52 polymorphisms contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.
Siraj AK, Al-Rasheed M, Ibrahim M, Siddiqui K, Al-Dayel F, Al-Sanea O, Uddin S, Al-Kuraya K
J Endocrinol Invest. 2008
PubMed ID: 19092295
IGFBP2 is overexpressed by pediatric malignant astrocytomas and induces the repair enzyme DNA-PK.
Becher OJ, Peterson KM, Khatua S, Santi MR, MacDonald TJ
J Child Neurol. 2008
PubMed ID: 18952587
STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease.
O'Malley JT, Eri RD, Stritesky GL, Mathur AN, Chang HC, Hogenesch H, Srinivasan M, Kaplan MH
J Immunol. 2008
PubMed ID: 18802110
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells.
Ruis BL, Fattah KR, Hendrickson EA
Mol Cell Biol. 2008
PubMed ID: 18710952
Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice.
Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Takeda K, Utsunomiya H, Oda K, Warabi E, Ishii T, Osaka K, Hyodo I, Yamamoto M
Am J Physiol Gastrointest Liver Physiol. 2008
PubMed ID: 18687751
DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks.
Yu Y, Mahaney BL, Yano K, Ye R, Fang S, Douglas P, Chen DJ, Lees-Miller SP
DNA Repair (Amst). 2008
PubMed ID: 18644470
Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects.
Ingman WV, Robertson SA
Biol Reprod. 2008
PubMed ID: 18614704
Processing of clustered DNA damage in human breast cancer cells MCF-7 with partial DNA-PKcs deficiency.
Peddi P, Francisco DC, Cecil AM, Hair JM, Panayiotidis MI, Georgakilas AG
Cancer Lett. 2008
PubMed ID: 18550272
Requirement of myeloid cells for axon regeneration.
Barrette B, Hébert MA, Filali M, Lafortune K, Vallières N, Gowing G, Julien JP, Lacroix S
J Neurosci. 2008
PubMed ID: 18799670
EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.
Huston E, Lynch MJ, Mohamed A, Collins DM, Hill EV, MacLeod R, Krause E, Baillie GS, Houslay MD
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18728186
[Expression and clinical significance of DNA-PKcs in nasopharyngeal carcinoma].
Yan SS, Liu L, Liu ZG, Zeng MS, Song LB, Xia YF
Ai Zheng. 2008
PubMed ID: 18799040
DNA repair of clustered lesions in mammalian cells: involvement of non-homologous end-joining.
Malyarchuk S, Castore R, Harrison L
Nucleic Acids Res. 2008
PubMed ID: 18653525
T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice.
Kumar P, Ban HS, Kim SS, Wu H, Pearson T, Greiner DL, Laouar A, Yao J, Haridas V, Habiro K, Yang YG, Jeong JH, Lee KY, Kim YH, Kim SW, Peipp M, Fey GH, Manjunath N, Shultz LD, Lee SK, Shankar P
Cell. 2008
PubMed ID: 18691745
Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation.
Wang J, Cho S, Ueno A, Cheng L, Xu BY, Xu BY, Desrosiers MD, Shi Y, Yang Y
J Immunol. 2008
PubMed ID: 18684934
Cooperative role of macrophages and neutrophils in host Antiprotozoan resistance in mice acutely infected with Cryptosporidium parvum.
Takeuchi D, Jones VC, Kobayashi M, Suzuki F
Infect Immun. 2008
PubMed ID: 18519557
Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury.
Liebler JM, Lutzko C, Banfalvi A, Senadheera D, Aghamohammadi N, Crandall ED, Borok Z
Am J Physiol Lung Cell Mol Physiol. 2008
PubMed ID: 18515407
DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin.
Friesen C, Uhl M, Pannicke U, Schwarz K, Miltner E, Debatin KM
Mol Biol Cell. 2008
PubMed ID: 18508926
Immune responses to Pneumocystis murina are robust in healthy mice but largely absent in CD40 ligand-deficient mice.
Hernandez-Novoa B, Bishop L, Logun C, Munson PJ, Elnekave E, Rangel ZG, Barb J, Danner RL, Kovacs JA
J Leukoc Biol. 2008
PubMed ID: 18467653
Activities of DNA-PK and Ku86, but not Ku70, may predict sensitivity to cisplatin in human gliomas.
Shao CJ, Fu J, Shi HL, Mu YG, Chen ZP
J Neurooncol. 2008
PubMed ID: 18415044
Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers.
Danoy P, Michiels S, Dessen P, Pignat C, Boulet T, Monet M, Bouchardy C, Lathrop M, Sarasin A, Benhamou S
Int J Cancer. 2008
PubMed ID: 18449888
Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.
Toulany M, Kehlbach R, Florczak U, Sak A, Wang S, Chen J, Lobrich M, Rodemann HP
Mol Cancer Ther. 2008
PubMed ID: 18644989
Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo.
Touvrey C, Couedel C, Soulas P, Couderc R, Jasin M, de Villartay JP, Marche PN, Jouvin-Marche E, Candéias SM
Mol Immunol. 2008
PubMed ID: 18501428
p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK.
Boehme KA, Kulikov R, Blattner C
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18505846
Genetic variants of the XRCC7 gene involved in DNA repair and risk of human bladder cancer.
Wang SY, Peng L, Li CP, Li AP, Zhou JW, Zhang ZD, Liu QZ
Int J Urol. 2008
PubMed ID: 18422577
CD4+ T lymphocytes mediate hypercholesterolemia-induced endothelial dysfunction via a NAD(P)H oxidase-dependent mechanism.
Wolfort RM, Stokes KY, Granger DN
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 18408127
Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice.
Simpson-Abelson MR, Sonnenberg GF, Takita H, Yokota SJ, Conway TF, Kelleher RJ, Shultz LD, Barcos M, Bankert RB
J Immunol. 2008
PubMed ID: 18453623
IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens.
Dann SM, Spehlmann ME, Hammond DC, Iimura M, Hase K, Choi LJ, Hanson E, Eckmann L
J Immunol. 2008
PubMed ID: 18453602
Creation of "humanized" mice to study human immunity.
Pearson T, Greiner DL, Shultz LD
Curr Protoc Immunol. 2008
PubMed ID: 18491294
Tagging single nucleotide polymorphisms in phosphoinositide-3-kinase-related protein kinase genes involved in DNA damage "checkpoints" and lung cancer susceptibility.
Hu Z, Liu H, Wang H, Miao R, Sun W, Jin G, Wang Y, Ma H, Jin L, Wei Q, Lu D, Huang W, Shen H
Clin Cancer Res. 2008
PubMed ID: 18451257
Antigen receptor editing in anti-DNA transitional B cells deficient for surface IgM.
Kiefer K, Nakajima PB, Oshinsky J, Seeholzer SH, Radic M, Bosma GC, Bosma MJ
J Immunol. 2008
PubMed ID: 18424731
Interleukin-12 and host defense against murine Pneumocystis pneumonia.
Ruan S, McKinley L, Zheng M, Rudner X, D'Souza A, Kolls JK, Shellito JE
Infect Immun. 2008
PubMed ID: 18332204
Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.
Kunisawa J, Gohda M, Kurashima Y, Ishikawa I, Higuchi M, Kiyono H
Blood. 2008
PubMed ID: 18292290
PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival.
Bozulic L, Surucu B, Hynx D, Hemmings BA
Mol Cell. 2008
PubMed ID: 18439899
Activation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitro.
Shank LC, Kelley JB, Gioeli D, Yang CS, Spencer A, Allison LA, Paschal BM
J Biol Chem. 2008
PubMed ID: 18270197
FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16.
Heo K, Kim H, Choi SH, Choi J, Kim K, Gu J, Lieber MR, Yang AS, An W
Mol Cell. 2008
PubMed ID: 18406329
Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription.
Kim K, Choi J, Heo K, Kim H, Levens D, Kohno K, Johnson EM, Brock HW, An W
J Biol Chem. 2008
PubMed ID: 18258596
DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.
Franco S, Murphy MM, Li G, Borjeson T, Boboila C, Alt FW
J Exp Med. 2008
PubMed ID: 18316419
Intestinal epithelial cell up-regulation of LY6 molecules during colitis results in enhanced chemokine secretion.
Flanagan K, Modrusan Z, Cornelius J, Chavali A, Kasman I, Komuves L, Mo L, Diehl L
J Immunol. 2008
PubMed ID: 18322195
Endosomal translocation of CpG-oligodeoxynucleotides inhibits DNA-PKcs-dependent IL-10 production in macrophages.
Yotsumoto S, Saegusa K, Aramaki Y
J Immunol. 2008
PubMed ID: 18178819
Physical and in silico approaches identify DNA-PK in a Tax DNA-damage response interactome.
Ramadan E, Ward M, Guo X, Durkin SS, Sawyer A, Vilela M, Osgood C, Pothen A, Semmes OJ
Retrovirology. 2008
PubMed ID: 18922151
Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK.
Dittmann K, Mayer C, Kehlbach R, Rodemann HP
Mol Cancer. 2008
PubMed ID: 18789131
DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein.
An J, Yang DY, Xu QZ, Zhang SM, Huo YY, Shang ZF, Wang Y, Wu DC, Zhou PK
Mol Cancer. 2008
PubMed ID: 18426604
GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma.
Anderson MG, Nair KS, Amonoo LA, Mehalow A, Trantow CM, Masli S, John SW
BMC Genet. 2008
PubMed ID: 18402690
DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells.
Arlander SJ, Greene BT, Innes CL, Paules RS
Cancer Res. 2008
PubMed ID: 18172300
Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons.
Benner EJ, Banerjee R, Reynolds AD, Sherman S, Pisarev VM, Tsiperson V, Nemachek C, Ciborowski P, Przedborski S, Mosley RL, Gendelman HE
PLoS ONE. 2008
PubMed ID: 18167537
Macrophages driven to a novel state of activation have anti-inflammatory properties in mice.
Brem-Exner BG, Sattler C, Hutchinson JA, Koehl GE, Kronenberg K, Farkas S, Inoue S, Blank C, Knechtle SJ, Schlitt HJ, Fändrich F, Geissler EK
J Immunol. 2008
PubMed ID: 18097035
Use of a genetically engineered strain to evaluate the pathogenic potential of yeast cell and filamentous forms during Candida albicans systemic infection in immunodeficient mice.
Saville SP, Lazzell AL, Chaturvedi AK, Monteagudo C, Lopez-Ribot JL
Infect Immun. 2008
PubMed ID: 17967861
Polymorphisms in DNA repair genes, ionizing radiation exposure and risk of breast cancer in U.S. Radiologic technologists.
Bhatti P, Struewing JP, Alexander BH, Hauptmann M, Bowen L, Mateus-Pereira LH, Pineda MA, Simon SL, Weinstock RM, Rosenstein M, Stovall M, Preston DL, Linet MS, Doody MM, Sigurdson AJ
Int J Cancer. 2008
PubMed ID: 17764108
DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication.
Müller B, Blackburn J, Feijoo C, Zhao X, Smythe C
J Cell Biol. 2007
PubMed ID: 18158334
Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients.
Kwun J, Hu H, Schadde E, Roenneburg D, Sullivan KA, DeMartino J, Burlingham WJ, Knechtle SJ
J Immunol. 2007
PubMed ID: 18056341
Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood.
Majeti R, Park CY, Weissman IL
Cell Stem Cell. 2007
PubMed ID: 18371405
A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair.
Wu S, Shi Y, Mulligan P, Gay F, Landry J, Liu H, Lu J, Qi HH, Wang W, Nickoloff JA, Wu C, Shi Y
Nat Struct Mol Biol. 2007
PubMed ID: 18026119
Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells.
Takenaka K, Prasolava TK, Wang JC, Mortin-Toth SM, Khalouei S, Gan OI, Dick JE, Danska JS
Nat Immunol. 2007
PubMed ID: 17982459
Dynamic change of histone H2AX phosphorylation independent of ATM and DNA-PK in mouse skin in situ.
Koike M, Mashino M, Sugasawa J, Koike A
Biochem Biophys Res Commun. 2007
PubMed ID: 17923115
Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guérin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity.
Yan BS, Pichugin AV, Jobe O, Helming L, Eruslanov EB, Gutiérrez-Pabello JA, Rojas M, Shebzukhov YV, Kobzik L, Kramnik I
J Immunol. 2007
PubMed ID: 17982083
[Expression and significance of GLUT-1 and DNA-PKcs in serous ovarian tumors]
Cai Y, Shao SL, Wang QH, Yan LJ, Wang XY, Wang LX
Ai Zheng. 2007
PubMed ID: 17991316
Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate.
Samy ET, Meyer CA, Caplazi P, Langrish CL, Lora JM, Bluethmann H, Peng SL
J Immunol. 2007
PubMed ID: 17947634
Characterization of an immunodeficient mouse model of mucopolysaccharidosis type I suitable for preclinical testing of human stem cell and gene therapy.
Garcia-Rivera MF, Colvin-Wanshura LE, Nelson MS, Nan Z, Khan SA, Rogers TB, Maitra I, Low WC, Gupta P
Brain Res Bull. 2007
PubMed ID: 17920451
Behavior of CD34+ cells isolated from patients with polycythemia vera in NOD/SCID mice.
Ishii T, Zhao Y, Sozer S, Shi J, Zhang W, Hoffman R, Xu M
Exp Hematol. 2007
PubMed ID: 17764815
VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes.
Halin C, Tobler NE, Vigl B, Brown LF, Detmar M
Blood. 2007
PubMed ID: 17625067
Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in recombinant inbred mice.
Llamas B, Bélanger S, Picard S, Deschepper CF
Physiol Genomics. 2007
PubMed ID: 17566079
Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients.
Someya M, Sakata K, Matsumoto Y, Tauchi H, Narimatsu H, Hareyama M
Oncol Rep. 2007
PubMed ID: 17786349
Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer.
Lee HS, Choe G, Park KU, Park do J, Yang HK, Lee BL, Kim WH
Int J Oncol. 2007
PubMed ID: 17786318
The role of DNA-PKcs and artemis in opening viral DNA hairpin termini in various tissues in mice.
Inagaki K, Ma C, Storm TA, Kay MA, Nakai H
J Virol. 2007
PubMed ID: 17686847
Toward development of a novel NOD/SCID-based in vivo strategy to model multiple myeloma pathogenesis.
Bueno C, Lopes LF, Greaves M, Menendez P
Exp Hematol. 2007
PubMed ID: 17681665
T and B lymphocyte depletion has a marked effect on the fibrosis of dystrophic skeletal muscles in the scid/mdx mouse.
Farini A, Meregalli M, Belicchi M, Battistelli M, Parolini D, D'Antona G, Gavina M, Ottoboni L, Constantin G, Bottinelli R, Torrente Y
J Pathol. 2007
PubMed ID: 17668421
PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration.
Eiseler T, Schmid MA, Topbas F, Pfizenmaier K, Hausser A
FEBS Lett. 2007
PubMed ID: 17707375
[Expression of GLUT-1, p63 and DNA-Pkcs in serous ovarian tumors and their significance]
Shao SL, Cai Y, Wang QH, Yan LJ, Zhao XY, Wang LX
Zhonghua Zhong Liu Za Zhi. 2007
PubMed ID: 18246802
Tagging SNPs in non-homologous end-joining pathway genes and risk of glioma.
Liu Y, Zhang H, Zhou K, Chen L, Xu Z, Zhong Y, Liu H, Li R, Shugart YY, Wei Q, Jin L, Huang F, Lu D, Zhou L
Carcinogenesis. 2007
PubMed ID: 17389609
Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction.
Ingman WV, Robertson SA
Endocrinology. 2007
PubMed ID: 17478551
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.
Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride K, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A
Cell. 2007
PubMed ID: 17599403
Maternal effects of the scid mutation on radiation-induced transgenerational instability in mice.
Hatch T, Derijck AA, Black PD, van der Heijden GW, de Boer P, Dubrova YE
Oncogene. 2007
PubMed ID: 17237807
Semi-automatic classification of skeletal morphology in genetically altered mice using flat-panel volume computed tomography.
Dullin C, Missbach-Guentner J, Vogel WF, Grabbe E, Alves F
PLoS Genet. 2007
PubMed ID: 17658952
[Potentials of DNA-PKcs, Ku80, and ATM in enhancing radiosensitivity of cervical carcinoma cells]
Zhuang L, Yu SY, Huang XY, Cao Y, Xiong HH
Ai Zheng. 2007
PubMed ID: 17626748
The molecular causes of low ATM protein expression in breast carcinoma; promoter methylation and levels of the catalytic subunit of DNA-dependent protein kinase.
Treilleux I, Chapot B, Goddard S, Pisani P, Angèle S, Hall J
Histopathology. 2007
PubMed ID: 17593081
Correction of DNA protein kinase deficiency by spliceosome-mediated RNA trans-splicing and sleeping beauty transposon delivery.
Zayed H, Xia L, Yerich A, Yant SR, Kay MA, Puttaraju M, McGarrity GJ, Wiest DL, McIvor RS, Tolar J, Blazar BR
Mol Ther. 2007
PubMed ID: 17457319
T cells are essential for bacterial clearance, and gamma interferon, tumor necrosis factor alpha, and B cells are crucial for disease development in Coxiella burnetii infection in mice.
Andoh M, Zhang G, Russell-Lodrigue KE, Shive HR, Weeks BR, Samuel JE
Infect Immun. 2007
PubMed ID: 17438029
DNA-PK phosphorylation sites on Oct-1 promote cell survival following DNA damage.
Schild-Poulter C, Shih A, Tantin D, Yarymowich NC, Soubeyrand S, Sharp PA, Haché RJ
Oncogene. 2007
PubMed ID: 17213819
Existence of a threshold-like dose for gamma-ray induction of thymic lymphomas and no susceptibility to radiation-induced solid tumors in SCID mice.
Ishii-Ohba H, Kobayashi S, Nishimura M, Shimada Y, Tsuji H, Sado T, Ogiu T
Mutat Res. 2007
PubMed ID: 17397880
Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system.
Burdeinick-Kerr R, Wind J, Griffin DE
J Virol. 2007
PubMed ID: 17376910
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK.
Costantini S, Woodbine L, Andreoli L, Jeggo PA, Vindigni A
DNA Repair (Amst). 2007
PubMed ID: 17241822
Phosphorylation of RNA helicase A by DNA-dependent protein kinase is indispensable for expression of the MDR1 gene product P-glycoprotein in multidrug-resistant human leukemia cells.
Zhong X, Safa AR
Biochemistry. 2007
PubMed ID: 17441731
Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres.
Wong KK, Maser RS, Sahin E, Bailey ST, Xia H, Ji H, McNamara K, Naylor M, Bronson RT, Ghosh S, Welsh R, DePinho RA
Oncogene. 2007
PubMed ID: 17072335
De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.
Tadokoro Y, Ema H, Okano M, Li E, Nakauchi H
J Exp Med. 2007
PubMed ID: 17420264
MyD88 is required for the formation of long-term humoral immunity to virus infection.
Guay HM, Andreyeva TA, Garcea RL, Welsh RM, Szomolanyi-Tsuda E
J Immunol. 2007
PubMed ID: 17404295
Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice.
Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Flaherty KR, Martinez FJ, Hogaboam CM
Am J Pathol. 2007
PubMed ID: 17392156
Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity.
Jeyakumar M, Liu XF, Erdjument-Bromage H, Tempst P, Bagchi MK
J Biol Chem. 2007
PubMed ID: 17242407
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.
Chen BP, Uematsu N, Kobayashi J, Lerenthal Y, Krempler A, Yajima H, Löbrich M, Shiloh Y, Chen DJ
J Biol Chem. 2007
PubMed ID: 17189255
Effect of hepatocyte growth factor on long term hematopoiesis of human progenitor cells in transgenic-severe combined immunodeficiency mice.
Sugiura K, Taketani S, Yoshimura T, Nishino T, Nishino N, Fujisawa J, Hisha H, Inaba T, Ikehara S
Cytokine. 2007
PubMed ID: 17512212
Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitis.
Hontecillas R, Bassaganya-Riera J
J Immunol. 2007
PubMed ID: 17312139
DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.
Maser RS, Wong KK, Sahin E, Xia H, Naylor M, Hedberg HM, Artandi SE, DePinho RA
Mol Cell Biol. 2007
PubMed ID: 17145779
The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination.
Kiefer K, Oshinsky J, Kim J, Nakajima PB, Bosma GC, Bosma MJ
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17296939
A role for the HOXB7 homeodomain protein in DNA repair.
Rubin E, Wu X, Zhu T, Cheung JC, Chen H, Lorincz A, Pandita RK, Sharma GG, Ha HC, Gasson J, Hanakahi LA, Pandita TK, Sukumar S
Cancer Res. 2007
PubMed ID: 17308091
Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.
Cannavo E, Gerrits B, Marra G, Schlapbach R, Jiricny J
J Biol Chem. 2007
PubMed ID: 17148452
Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair.
Fang L, Wang Y, Du D, Yang G, Tak Kwok T, Kai Kong S, Chen B, Chen DJ, Chen Z
Cell Res. 2007
PubMed ID: 17287830
Humanized mice in translational biomedical research.
Shultz LD, Ishikawa F, Greiner DL
Nat Rev Immunol. 2007
PubMed ID: 17259968
Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.
Koch HB, Zhang R, Verdoodt B, Bailey A, Zhang CD, Yates JR, Menssen A, Hermeking H
Cell Cycle. 2007
PubMed ID: 17314511
Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase.
Karlsson KH, Stenerlöw B
BMC Mol Biol. 2007
PubMed ID: 17963495
Extent to which hairpin opening by the Artemis:DNA-PKcs complex can contribute to junctional diversity in V(D)J recombination.
Lu H, Schwarz K, Lieber MR
Nucleic Acids Res. 2007
PubMed ID: 17932067
Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts.
Povirk LF, Zhou RZ, Ramsden DA, Lees-Miller SP, Valerie K
Nucleic Acids Res. 2007
PubMed ID: 17526517
Dynamic binding of Ku80, Ku70 and NF90 to the IL-2 promoter in vivo in activated T-cells.
Shi L, Qiu D, Zhao G, Corthesy B, Lees-Miller S, Reeves WH, Kao PN
Nucleic Acids Res. 2007
PubMed ID: 17389650
Polymorphisms of DNA repair genes are risk factors for prostate cancer.
Hirata H, Hinoda Y, Tanaka Y, Okayama N, Suehiro Y, Kawamoto K, Kikuno N, Majid S, Vejdani K, Dahiya R
Eur J Cancer. 2007
PubMed ID: 17196815
B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection.
Noorchashm H, Reed AJ, Rostami SY, Mozaffari R, Zekavat G, Koeberlein B, Caton AJ, Naji A
J Immunol. 2006
PubMed ID: 17114442
Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp.
Bolz DD, Sundsbak RS, Ma Y, Akira S, Weis JH, Schwan TG, Weis JJ
Infect Immun. 2006
PubMed ID: 17030581
IL-10 deficiency promotes increased Borrelia burgdorferi clearance predominantly through enhanced innate immune responses.
Lazarus JJ, Meadows MJ, Lintner RE, Wooten RM
J Immunol. 2006
PubMed ID: 17082624
Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages.
Liebe B, Petukhova G, Barchi M, Bellani M, Braselmann H, Nakano T, Pandita TK, Jasin M, Fornace A, Meistrich ML, Baarends WM, Schimenti J, de Lange T, Keeney S, Camerini-Otero RD, Scherthan H
Exp Cell Res. 2006
PubMed ID: 17010969
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Prolactin delays hair regrowth in mice.
Craven AJ, Nixon AJ, Ashby MG, Ormandy CJ, Blazek K, Wilkins RJ, Pearson AJ
J Endocrinol. 2006
PubMed ID: 17088411
The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation.
Gelman AE, LaRosa DF, Zhang J, Walsh PT, Choi Y, Sunyer JO, Turka LA
Immunity. 2006
PubMed ID: 17055754
Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression.
Yamasaki H, Sada A, Iwata T, Niwa T, Tomizawa M, Xanthopoulos KG, Koike T, Shiojiri N
Development. 2006
PubMed ID: 17021047
Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model.
Kometani K, Aoki M, Kawamata S, Shinozuka Y, Era T, Taniwaki M, Hattori M, Minato N
Cancer Res. 2006
PubMed ID: 17047059
Matrix metalloproteinase 9 (MMP-9) is upregulated during scarless wound healing in athymic nude mice.
Manuel JA, Gawronska-Kozak B
Matrix Biol. 2006
PubMed ID: 17010584
Leydig cell function in mice lacking connexin43.
Kahiri CN, Khalil MW, Tekpetey F, Kidder GM
Reproduction. 2006
PubMed ID: 17008472
Suppression of experimental colitis by intestinal mononuclear phagocytes.
Qualls JE, Kaplan AM, van Rooijen N, Cohen DA
J Leukoc Biol. 2006
PubMed ID: 16888083
Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends.
Drouet J, Frit P, Delteil C, de Villartay JP, Salles B, Calsou P
J Biol Chem. 2006
PubMed ID: 16857680
Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration.
Trowbridge JJ, Scott MP, Bhatia M
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16968775
DNA-PK autophosphorylation facilitates Artemis endonuclease activity.
Goodarzi AA, Yu Y, Riballo E, Douglas P, Walker SA, Ye R, Härer C, Marchetti C, Morrice N, Jeggo PA, Lees-Miller SP
EMBO J. 2006
PubMed ID: 16874298
Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death.
Lu D, Huang J, Basu A
J Biol Chem. 2006
PubMed ID: 16785234
Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.
Uhlig HH, McKenzie BS, Hue S, Thompson C, Joyce-Shaikh B, Stepankova R, Robinson N, Buonocore S, Tlaskalova-Hogenova H, Cua DJ, Powrie F
Immunity. 2006
PubMed ID: 16919486
Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance.
Ambrosino E, Spadaro M, Iezzi M, Curcio C, Forni G, Musiani P, Wei WZ, Cavallo F
Cancer Res. 2006
PubMed ID: 16885376
Interaction of natural killer cells with Trypanosoma cruzi-infected fibroblasts.
Lieke T, Steeg C, Graefe SE, Fleischer B, Jacobs T
Clin Exp Immunol. 2006
PubMed ID: 16879257
Antibody-mediated disease remission in the mouse model of lyme borreliosis.
Barthold SW, Hodzic E, Tunev S, Feng S
Infect Immun. 2006
PubMed ID: 16861670
Role of transcription factor T-bet expression by CD4+ cells in gastritis due to Helicobacter pylori in mice.
Eaton KA, Benson LH, Haeger J, Gray BM
Infect Immun. 2006
PubMed ID: 16861655
Aggregative organization enhances the DNA end-joining process that is mediated by DNA-dependent protein kinase.
Takahagi M, Tatsumi K
FEBS J. 2006
PubMed ID: 16759233
VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization.
Li B, Sharpe EE, Maupin AB, Teleron AA, Pyle AL, Carmeliet P, Young PP
FASEB J. 2006
PubMed ID: 16754748
HIV-1 Tat depresses DNA-PK(CS) expression and DNA repair, and sensitizes cells to ionizing radiation.
Sun Y, Huang YC, Xu QZ, Wang HP, Bai B, Sui JL, Zhou PK
Int J Radiat Oncol Biol Phys. 2006
PubMed ID: 16751065
A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.
Ju BG, Lunyak VV, Perissi V, Garcia-Bassets I, Rose DW, Glass CK, Rosenfeld MG
Science. 2006
PubMed ID: 16794079
The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.
Jiang X, Sun Y, Chen S, Roy K, Price BD
J Biol Chem. 2006
PubMed ID: 16603769
Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair.
Spagnolo L, Rivera-Calzada A, Pearl LH, Llorca O
Mol Cell. 2006
PubMed ID: 16713581
Artemis phosphorylated by DNA-dependent protein kinase associates preferentially with discrete regions of chromatin.
Soubeyrand S, Pope L, De Chasseval R, Gosselin D, Dong F, de Villartay JP, Haché RJ
J Mol Biol. 2006
PubMed ID: 16600297
Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.
Riedel CG, Katis VL, Katou Y, Mori S, Itoh T, Helmhart W, Gálová M, Petronczki M, Gregan J, Cetin B, Mudrak I, Ogris E, Mechtler K, Pelletier L, Buchholz F, Shirahige K, Nasmyth K
Nature. 2006
PubMed ID: 16541024
Scarless skin repair in immunodeficient mice.
Gawronska-Kozak B, Bogacki M, Rim JS, Monroe WT, Manuel JA
Wound Repair Regen. 2006
PubMed ID: 16808805
CD4+ T-cell modulation of visceral nociception in mice.
Verma-Gandhu M, Bercik P, Motomura Y, Verdu EF, Khan WI, Blennerhassett PA, Wang L, El-Sharkawy RT, Collins SM
Gastroenterology. 2006
PubMed ID: 16697736
p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc.
Gladdy RA, Nutter LM, Kunath T, Danska JS, Guidos CJ
Mol Cancer Res. 2006
PubMed ID: 16687486
Gene therapy: therapeutic gene causing lymphoma.
Woods NB, Bottero V, Schmidt M, von Kalle C, Verma IM
Nature. 2006
PubMed ID: 16641981
Polymorphisms of DNA repair genes are associated with renal cell carcinoma.
Hirata H, Hinoda Y, Matsuyama H, Tanaka Y, Okayama N, Suehiro Y, Zhao H, Urakami S, Kawamoto K, Kawakami T, Igawa M, Naito K, Dahiya R
Biochem Biophys Res Commun. 2006
PubMed ID: 16510122
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract.
Owyang AM, Zaph C, Wilson EH, Guild KJ, McClanahan T, Miller HR, Cua DJ, Goldschmidt M, Hunter CA, Kastelein RA, Artis D
J Exp Med. 2006
PubMed ID: 16606667
Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes.
Carrero JA, Calderon B, Unanue ER
J Exp Med. 2006
PubMed ID: 16549598
UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK.
Cruet-Hennequart S, Coyne S, Glynn MT, Oakley GG, Carty MP
DNA Repair (Amst). 2006
PubMed ID: 16520097
Analysis of DNA-dependent protein kinase-mediated DNA end joining by two-photon fluorescence cross-correlation spectroscopy.
Merkle D, Block WD, Yu Y, Lees-Miller SP, Cramb DT
Biochemistry. 2006
PubMed ID: 16566590
Phosphoproteome analysis of the human mitotic spindle.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16565220
Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon.
O'Hara JR, Skinn AC, MacNaughton WK, Sherman PM, Sharkey KA
Cell Microbiol. 2006
PubMed ID: 16548890
Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation.
Wu X, Shell SM, Yang Z, Zou Y
Cancer Res. 2006
PubMed ID: 16540648
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.
Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC
Nature. 2006
PubMed ID: 16400328
Modulation of MOG 37-50-specific CD8+ T cell activation and expansion by CD43.
Ford ML, Evavold BD
Cell Immunol. 2006
PubMed ID: 16890924
Identification of a B-1 B cell-specified progenitor.
Montecino-Rodriguez E, Leathers H, Dorshkind K
Nat Immunol. 2006
PubMed ID: 16429139
Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint.
Pedraza-Alva G, Koulnis M, Charland C, Thornton T, Clements JL, Schlissel MS, Rincón M
EMBO J. 2006
PubMed ID: 16456545
Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.
Shiio Y, Rose DW, Aur R, Donohoe S, Aebersold R, Eisenman RN
Mol Cell Biol. 2006
PubMed ID: 16449650
Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden.
Viriyakosol S, Matthias MA, Swancutt MA, Kirkland TN, Vinetz JM
Infect Immun. 2006
PubMed ID: 16428731
Null mutation in transforming growth factor beta1 disrupts ovarian function and causes oocyte incompetence and early embryo arrest.
Ingman WV, Robker RL, Woittiez K, Robertson SA
Endocrinology. 2006
PubMed ID: 16269452
DNA sequence and analysis of human chromosome 8.
Nusbaum C, Mikkelsen TS, Zody MC, Asakawa S, Taudien S, Garber M, Kodira CD, Schueler MG, Shimizu A, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Allen NR, Anderson S, Asakawa T, Blechschmidt K, Bloom T, Borowsky ML, Butler J, Cook A, Corum B, DeArellano K, DeCaprio D, Dooley KT, Dorris L, Engels R, Glöckner G, Hafez N, Hagopian DS, Hall JL, Ishikawa SK, Jaffe DB, Kamat A, Kudoh J, Lehmann R, Lokitsang T, Macdonald P, Major JE, Matthews CD, Mauceli E, Menzel U, Mihalev AH, Minoshima S, Murayama Y, Naylor JW, Nicol R, Nguyen C, O'Leary SB, O'Neill K, Parker SC, Polley A, Raymond CK, Reichwald K, Rodriguez J, Sasaki T, Schilhabel M, Siddiqui R, Smith CL, Sneddon TP, Talamas JA, Tenzin P, Topham K, Venkataraman V, Wen G, Yamazaki S, Young SK, Zeng Q, Zimmer AR, Rosenthal A, Birren BW, Platzer M, Shimizu N, Lander ES
Nature. 2006
PubMed ID: 16421571
Development of functional B cells in a line of SCID mice with transgenes coding for anti-double-stranded DNA antibody.
Bosma GC, Oshinsky J, Kiefer K, Nakajima PB, Charan D, Congelton C, Radic M, Bosma MJ
J Immunol. 2006
PubMed ID: 16393973
The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability.
Yeh ES, Lew BO, Means AR
J Biol Chem. 2006
PubMed ID: 16223725
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.
Stetson DB, Medzhitov R
Immunity. 2006
PubMed ID: 16413926
Nonhomologous end-joining deficiency of L5178Y-S cells is not associated with mutation in the ABCDE autophosphorylation cluster.
Brzóska K, Kruszewski M, Szumiel I
Acta Biochim Pol. 2006
PubMed ID: 16404475
XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage.
Lévy N, Martz A, Bresson A, Spenlehauer C, de Murcia G, Ménissier-de Murcia J
Nucleic Acids Res. 2006
PubMed ID: 16397295
Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice.
Li E, Zhou P, Singer SM
J Immunol. 2006
PubMed ID: 16365445
The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.
Someya M, Sakata K, Matsumoto Y, Yamamoto H, Monobe M, Ikeda H, Ando K, Hosoi Y, Suzuki N, Hareyama M
Carcinogenesis. 2006
PubMed ID: 16000400
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.
Hresko RC, Mueckler M
J Biol Chem. 2005
PubMed ID: 16221682
Endocrine self and gut non-self intersect in the pancreatic lymph nodes.
Turley SJ, Lee JW, Dutton-Swain N, Mathis D, Benoist C
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16317068
Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.
Niture SK, Doneanu CE, Velu CS, Bailey NI, Srivenugopal KS
Biochem Biophys Res Commun. 2005
PubMed ID: 16226712
Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice.
Cui X, Yu Y, Gupta S, Cho YM, Lees-Miller SP, Meek K
Mol Cell Biol. 2005
PubMed ID: 16314509
CD4+ T cell-independent DNA vaccination against opportunistic infections.
Zheng M, Ramsay AJ, Robichaux MB, Norris KA, Kliment C, Crowe C, Rapaka RR, Steele C, McAllister F, Shellito JE, Marrero L, Schwarzenberger P, Zhong Q, Kolls JK
J Clin Invest. 2005
PubMed ID: 16308571
Immunological control of methicillin-resistant Staphylococcus aureus (MRSA) infection in an immunodeficient murine model of thermal injuries.
Katakura T, Yoshida T, Kobayashi M, Herndon DN, Suzuki F
Clin Exp Immunol. 2005
PubMed ID: 16297152
M-CSF mediates TNF-induced inflammatory osteolysis.
Kitaura H, Zhou P, Kim HJ, Novack DV, Ross FP, Teitelbaum SL
J Clin Invest. 2005
PubMed ID: 16294221
Postreplicative joining of DNA double-strand breaks causes genomic instability in DNA-PKcs-deficient mouse embryonic fibroblasts.
Martín M, Genescà A, Latre L, Jaco I, Taccioli GE, Egozcue J, Blasco MA, Iliakis G, Tusell L
Cancer Res. 2005
PubMed ID: 16288010
Proteomic analysis of ubiquitinated proteins from human MCF-7 breast cancer cells by immunoaffinity purification and mass spectrometry.
Vasilescu J, Smith JC, Ethier M, Figeys D
J Proteome Res. 2005
PubMed ID: 16335966
Lymphotoxin-beta receptor signaling is required for the homeostatic control of HEV differentiation and function.
Browning JL, Allaire N, Ngam-Ek A, Notidis E, Hunt J, Perrin S, Fava RA
Immunity. 2005
PubMed ID: 16286021
Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model.
van Rossum AM, Lysenko ES, Weiser JN
Infect Immun. 2005
PubMed ID: 16239576
Cardiac apoptosis in severe relapsing fever borreliosis.
Londoño D, Bai Y, Zückert WR, Gelderblom H, Cadavid D
Infect Immun. 2005
PubMed ID: 16239571
Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining.
Houghtaling S, Newell A, Akkari Y, Taniguchi T, Olson S, Grompe M
Hum Mol Genet. 2005
PubMed ID: 16135554
Global loss of imprinting leads to widespread tumorigenesis in adult mice.
Holm TM, Jackson-Grusby L, Brambrink T, Yamada Y, Rideout WM, Jaenisch R
Cancer Cell. 2005
PubMed ID: 16226703
DNA-PK is responsible for enhanced phosphorylation of histone H2AX under hypertonic conditions.
Reitsema T, Klokov D, Banáth JP, Olive PL
DNA Repair (Amst). 2005
PubMed ID: 16046194
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase.
Dittmann K, Mayer C, Fehrenbacher B, Schaller M, Raju U, Milas L, Chen DJ, Kehlbach R, Rodemann HP
J Biol Chem. 2005
PubMed ID: 16000298
Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.
De Palma M, Venneri MA, Galli R, Sergi Sergi L, Politi LS, Sampaolesi M, Naldini L
Cancer Cell. 2005
PubMed ID: 16169466
Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice.
Ishikawa F, Yasukawa M, Lyons B, Yoshida S, Miyamoto T, Yoshimoto G, Watanabe T, Akashi K, Shultz LD, Harada M
Blood. 2005
PubMed ID: 15920010
The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.
Akiba H, Takeda K, Kojima Y, Usui Y, Harada N, Yamazaki T, Ma J, Tezuka K, Yagita H, Okumura K
J Immunol. 2005
PubMed ID: 16081804
Novel role of the Ras cascade in memory B cell response.
Takahashi Y, Inamine A, Hashimoto S, Haraguchi S, Yoshioka E, Kojima N, Abe R, Takemori T
Immunity. 2005
PubMed ID: 16111632
SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes.
Bellani MA, Romanienko PJ, Cairatti DA, Camerini-Otero RD
J Cell Sci. 2005
PubMed ID: 15998665
The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps.
Ma Y, Schwarz K, Lieber MR
DNA Repair (Amst). 2005
PubMed ID: 15936993
p53 deficiency does not affect mutation rate in the mouse germline.
Burr KL, Smith AG, Dubrova YE
Oncogene. 2005
PubMed ID: 15806156
Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells.
Dhanalakshmi S, Agarwal C, Singh RP, Agarwal R
J Biol Chem. 2005
PubMed ID: 15792956
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Shultz LD, Lyons BL, Burzenski LM, Gott B, Chen X, Chaleff S, Kotb M, Gillies SD, King M, Mangada J, Greiner DL, Handgretinger R
J Immunol. 2005
PubMed ID: 15879151
Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression.
Wang J, Pluth JM, Cooper PK, Cowan MJ, Chen DJ, Yannone SM
DNA Repair (Amst). 2005
PubMed ID: 15811628
Reproductive and neurological Quaking(viable) phenotypes in a severe combined immune deficient mouse background.
Tucker TA, Kundert JA, Bondareva AA, Schmidt EE
Immunogenetics. 2005
PubMed ID: 15900494
Role of epidermal growth factor receptor signaling in RAS-driven melanoma.
Bardeesy N, Kim M, Xu J, Kim RS, Shen Q, Bosenberg MW, Wong WH, Chin L
Mol Cell Biol. 2005
PubMed ID: 15870287
A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection.
Suffia I, Reckling SK, Salay G, Belkaid Y
J Immunol. 2005
PubMed ID: 15845457
Role of type I IFNs in pulmonary complications of Pneumocystis murina infection.
Meissner NN, Swain S, Tighe M, Harmsen A, Harmsen A
J Immunol. 2005
PubMed ID: 15843544
Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.
Chen BP, Chan DW, Kobayashi J, Burma S, Asaithamby A, Morotomi-Yano K, Botvinick E, Qin J, Chen DJ
J Biol Chem. 2005
PubMed ID: 15677476
Glioblastoma cells deficient in DNA-dependent protein kinase are resistant to cell death.
Chen GG, Sin FL, Leung BC, Ng HK, Poon WS
J Cell Physiol. 2005
PubMed ID: 15493013
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.
Falck J, Coates J, Jackson SP
Nature. 2005
PubMed ID: 15758953
Regulation of CHK2 by DNA-dependent protein kinase.
Li J, Stern DF
J Biol Chem. 2005
PubMed ID: 15668230
Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells.
Mayeur GL, Kung WJ, Martinez A, Izumiya C, Chen DJ, Kung HJ
J Biol Chem. 2005
PubMed ID: 15640154
p53 prevents maturation of T cell development to the immature CD4-CD8+ stage in Bcl11b-/- mice.
Okazuka K, Wakabayashi Y, Kashihara M, Inoue J, Sato T, Yokoyama M, Aizawa S, Aizawa Y, Mishima Y, Kominami R
Biochem Biophys Res Commun. 2005
PubMed ID: 15694382
Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II.
Mischo HE, Hemmerich P, Grosse F, Zhang S
J Biol Chem. 2005
PubMed ID: 15613478
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells.
Fahlén L, Read S, Gorelik L, Hurst SD, Coffman RL, Flavell RA, Powrie F
J Exp Med. 2005
PubMed ID: 15753207
Toll-like receptor 9-induced type I IFN protects mice from experimental colitis.
Katakura K, Lee J, Rachmilewitz D, Li G, Eckmann L, Raz E
J Clin Invest. 2005
PubMed ID: 15765149
Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis.
Kiaris H, Chatzistamou I, Trimis G, Frangou-Plemmenou M, Pafiti-Kondi A, Kalofoutis A
Cancer Res. 2005
PubMed ID: 15753354
Interferon-gamma mediates antigen trafficking to MHC class II-positive late endosomes of enterocytes.
Büning J, Schmitz M, Repenning B, Ludwig D, Schmidt MA, Strobel S, Zimmer KP
Eur J Immunol. 2005
PubMed ID: 15688349
DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.
Drouet J, Delteil C, Lefrançois J, Concannon P, Salles B, Calsou P
J Biol Chem. 2005
PubMed ID: 15520013
DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.
Dragoi AM, Fu X, Ivanov S, Zhang P, Sheng L, Wu D, Li GC, Chu WM
EMBO J. 2005
PubMed ID: 15678105
Vigilins bind to promiscuously A-to-I-edited RNAs and are involved in the formation of heterochromatin.
Wang Q, Zhang Z, Blackwell K, Carmichael GG
Curr Biol. 2005
PubMed ID: 15723802
Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses.
Grenningloh R, Kang BY, Ho IC
J Exp Med. 2005
PubMed ID: 15728239
A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse.
Zheng Z, Schmidt-Ott KM, Chua S, Foster KA, Frankel RZ, Pavlidis P, Barasch J, D'Agati VD, Gharavi AG
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15699352
Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development.
Rooney S, Alt FW, Sekiguchi J, Manis JP
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15699324
Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles.
Nonaka S, Naito T, Chen H, Yamamoto M, Moro K, Kiyono H, Hamada H, Ishikawa H
J Immunol. 2005
PubMed ID: 15699117
Normal hematopoiesis is maintained by activated bone marrow CD4+ T cells.
Monteiro JP, Benjamin A, Costa ES, Barcinski MA, Bonomo A
Blood. 2005
PubMed ID: 15514013
Phosphorylation of linker histones by DNA-dependent protein kinase is required for DNA ligase IV-dependent ligation in the presence of histone H1.
Kysela B, Chovanec M, Jeggo PA
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15671175
The life and death of DNA-PK.
Collis SJ, DeWeese TL, Jeggo PA, Parker AR
Oncogene. 2005
PubMed ID: 15592499
Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).
Rivera-Calzada A, Maman JD, Maman JP, Spagnolo L, Pearl LH, Llorca O
Structure. 2005
PubMed ID: 15698568
Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs).
Convery E, Shin EK, Ding Q, Wang W, Douglas P, Davis LS, Nickoloff JA, Lees-Miller SP, Meek K
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15668400
Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells.
Rivera J, Zaragoza O, Casadevall A
Infect Immun. 2005
PubMed ID: 15664957
Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis.
Niimi N, Sugo N, Aratani Y, Koyama H
Cell Death Differ. 2005
PubMed ID: 15647757
Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors.
Wang H, Wang M, Wang H, Böcker W, Iliakis G
J Cell Physiol. 2005
PubMed ID: 15389585
The double-edged sword of activation-induced cytidine deaminase.
Wu X, Geraldes P, Platt JL, Cascalho M
J Immunol. 2005
PubMed ID: 15634916
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures.
Neema M, Navarro-Quiroga I, Chechlacz M, Gilliams-Francis K, Liu J, Lamonica K, Lin SL, Naegele JR
Hippocampus. 2005
PubMed ID: 16216017
The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism.
Pajonk F, van Ophoven A, Weissenberger C, McBride WH
BMC Cancer. 2005
PubMed ID: 16001975
HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins.
Van Maele B, Debyser Z
AIDS Rev. 2005
PubMed ID: 15875659
Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.
Liu Y, Shreder KR, Gai W, Corral S, Ferris DK, Rosenblum JS
Chem Biol. 2005
PubMed ID: 15664519
Interplay between paracrine signaling and gap junctional communication in ovarian follicles.
Gittens JE, Barr KJ, Vanderhyden BC, Kidder GM
J Cell Sci. 2005
PubMed ID: 15585573
Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl.
Zhang JQ, Okumura C, McCarty T, Shin MS, Mukhopadhyay P, Hori M, Torrey TA, Naghashfar Z, Zhou JX, Lee CH, Roopenian DC, Morse HC, Davidson WF
J Exp Med. 2004
PubMed ID: 15583018
A biochemically defined system for mammalian nonhomologous DNA end joining.
Ma Y, Lu H, Tippin B, Goodman MF, Shimazaki N, Koiwai O, Hsieh CL, Schwarz K, Lieber MR
Mol Cell. 2004
PubMed ID: 15574326
Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design.
Karki RG, Tang Y, Burke TR, Nicklaus MC
J Comput Aided Mol Des. 2004
PubMed ID: 16075307
TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice.
Horai R, Nakajima A, Habiro K, Kotani M, Nakae S, Matsuki T, Nambu A, Saijo S, Kotaki H, Sudo K, Okahara A, Tanioka H, Ikuse T, Ishii N, Schwartzberg PL, Abe R, Iwakura Y
J Clin Invest. 2004
PubMed ID: 15578092
Pivotal roles of interleukin-6 in transmural inflammation in murine T cell transfer colitis.
Kitamura K, Nakamoto Y, Kaneko S, Mukaida N
J Leukoc Biol. 2004
PubMed ID: 15339938
Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs.
Espejel S, Klatt P, Ménissier-de Murcia J, Martín-Caballero J, Flores JM, Taccioli G, de Murcia G, Blasco MA
J Cell Biol. 2004
PubMed ID: 15545322
MDC1 regulates DNA-PK autophosphorylation in response to DNA damage.
Lou Z, Chen BP, Asaithamby A, Minter-Dykhouse K, Chen DJ, Chen J
J Biol Chem. 2004
PubMed ID: 15377652
Specificity-based negative selection of autoreactive B cells during memory formation.
Guay HM, Panarey L, Reed AJ, Caton AJ
J Immunol. 2004
PubMed ID: 15494496
Potentiality of DNA-dependent protein kinase to phosphorylate Ser46 of human p53.
Komiyama S, Taniguchi S, Matsumoto Y, Tsunoda E, Ohto T, Suzuki Y, Yin HL, Tomita M, Enomoto A, Morita A, Suzuki T, Ohtomo K, Hosoi Y, Suzuki N
Biochem Biophys Res Commun. 2004
PubMed ID: 15381073
The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice.
Boyartchuk V, Rojas M, Yan BS, Jobe O, Hurt N, Dorfman DM, Higgins DE, Dietrich WF, Kramnik I
J Immunol. 2004
PubMed ID: 15470055
Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13.
Cupedo T, Lund FE, Ngo VN, Randall TD, Jansen W, Greuter MJ, de Waal-Malefyt R, Kraal G, Cyster JG, Mebius RE
J Immunol. 2004
PubMed ID: 15470030
Germline mutation rates at tandem repeat loci in DNA-repair deficient mice.
Barber RC, Miccoli L, van Buul PP, Burr KL, van Duyn-Goedhart A, Angulo JF, Dubrova YE
Mutat Res. 2004
PubMed ID: 15450426
CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis.
Dohi T, Fujihashi K, Koga T, Etani Y, Yoshino N, Kawamura YI, McGhee JR
Am J Pathol. 2004
PubMed ID: 15466391
Ablation of TrkA function in the immune system causes B cell abnormalities.
Coppola V, Barrick CA, Southon EA, Celeste A, Wang K, Chen B, Haddad el-B, Yin J, Nussenzweig A, Subramaniam A, Tessarollo L
Development. 2004
PubMed ID: 15459109
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.
Zhang X, Succi J, Feng Z, Prithivirajsingh S, Story MD, Legerski RJ
Mol Cell Biol. 2004
PubMed ID: 15456891
Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization.
McCool TL, Weiser JN
Infect Immun. 2004
PubMed ID: 15385481
A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor.
Chiang EY, Stroynowski I
J Immunol. 2004
PubMed ID: 15383569
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase.
Feng J, Park J, Cron P, Hess D, Hemmings BA
J Biol Chem. 2004
PubMed ID: 15262962
Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.
Veuger SJ, Curtin NJ, Smith GC, Durkacz BW
Oncogene. 2004
PubMed ID: 15286704
Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.
Reddy YV, Ding Q, Lees-Miller SP, Meek K, Ramsden DA
J Biol Chem. 2004
PubMed ID: 15258142
Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase.
Wang YG, Nnakwe C, Lane WS, Modesti M, Frank KM
J Biol Chem. 2004
PubMed ID: 15194694
Genomic analysis of mouse retinal development.
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
PLoS Biol. 2004
PubMed ID: 15226823
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T
Curr Biol. 2004
PubMed ID: 15324660
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15302935
Polymorphisms of DNA repair genes and risk of glioma.
Wang LE, Bondy ML, Shen H, El-Zein R, Aldape K, Cao Y, Pudavalli V, Levin VA, Yung WK, Wei Q
Cancer Res. 2004
PubMed ID: 15313891
DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase.
Lee GE, Yu EY, Cho CH, Lee J, Muller MT, Chung IK
J Biol Chem. 2004
PubMed ID: 15190070
Expression of DNA-dependent protein kinase in human granulocytes.
Sallmyr A, Miller A, Gabdoulkhakova A, Safronova V, Henriksson G, Bredberg A
Cell Res. 2004
PubMed ID: 15353130
Role of DNA-PK in the cellular response to DNA double-strand breaks.
Burma S, Chen DJ
DNA Repair (Amst). 2004
PubMed ID: 15279776
MyD88 plays a unique role in host defense but not arthritis development in Lyme disease.
Bolz DD, Sundsbak RS, Ma Y, Akira S, Kirschning CJ, Zachary JF, Weis JH, Weis JJ
J Immunol. 2004
PubMed ID: 15265935
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
Meek SE, Lane WS, Piwnica-Worms H
J Biol Chem. 2004
PubMed ID: 15161933
Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule.
Sawchuk DJ, Mansilla-Soto J, Alarcon C, Singha NC, Langen H, Bianchi ME, Lees-Miller SP, Nussenzweig MC, Cortes P
J Biol Chem. 2004
PubMed ID: 15123719
Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection.
Graham KL, Gustin KE, Rivera C, Kuyumcu-Martinez NM, Choe SS, Lloyd RE, Sarnow P, Utz PJ
J Virol. 2004
PubMed ID: 15163725
Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection.
Bitsaktsis C, Huntington J, Winslow G
J Immunol. 2004
PubMed ID: 15153508
Functional and biochemical dissection of the structure-specific nuclease ARTEMIS.
Pannicke U, Ma Y, Hopfner KP, Niewolik D, Lieber MR, Schwarz K
EMBO J. 2004
PubMed ID: 15071507
Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.
Espejel S, Martín M, Klatt P, Martín-Caballero J, Flores JM, Blasco MA
EMBO Rep. 2004
PubMed ID: 15105825
Arthritogenic properties of double-stranded (viral) RNA.
Zare F, Bokarewa M, Nenonen N, Bergström T, Alexopoulou L, Flavell RA, Tarkowski A
J Immunol. 2004
PubMed ID: 15100310
DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage.
Jack MT, Woo RA, Motoyama N, Takai H, Lee PW
J Biol Chem. 2004
PubMed ID: 14752107
Dysfunctional mammalian telomeres join with DNA double-strand breaks.
Bailey SM, Cornforth MN, Ullrich RL, Goodwin EH
DNA Repair (Amst). 2004
PubMed ID: 15010310
The kinase activity of DNA-PK is required to protect mammalian telomeres.
Bailey SM, Brenneman MA, Halbrook J, Nickoloff JA, Ullrich RL, Goodwin EH
DNA Repair (Amst). 2004
PubMed ID: 15177038
ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.
Panta GR, Kaur S, Cavin LG, Cortés ML, Mercurio F, Lothstein L, Sweatman TW, Israel M, Arsura M
Mol Cell Biol. 2004
PubMed ID: 14966265
DNA-dependent PK inhibits adeno-associated virus DNA integration.
Song S, Lu Y, Choi YK, Han Y, Tang Q, Zhao G, Berns KI, Flotte TR
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14766968
DNA-PKcs function regulated specifically by protein phosphatase 5.
Wechsler T, Chen BP, Harper R, Morotomi-Yano K, Huang BC, Meek K, Cleaver JE, Chen DJ, Wabl M
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14734805
The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination.
Poinsignon C, Moshous D, Callebaut I, de Chasseval R, Villey I, de Villartay JP
J Exp Med. 2004
PubMed ID: 14744996
DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner.
Zhang S, Schlott B, Görlach M, Grosse F
Nucleic Acids Res. 2004
PubMed ID: 14704337
Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions.
Cook AJ, Oganesian L, Harumal P, Basten A, Brink R, Jolly CJ
J Immunol. 2003
PubMed ID: 14662857
The role of DNA dependent protein kinase in synapsis of DNA ends.
Weterings E, Verkaik NS, Brüggenwirth HT, Hoeijmakers JH, van Gent DC
Nucleic Acids Res. 2003
PubMed ID: 14654699
Diabetogenic T cells are primed both in pancreatic and gut-associated lymph nodes in NOD mice.
Jaakkola I, Jalkanen S, Hänninen A
Eur J Immunol. 2003
PubMed ID: 14635033
DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner.
Park EJ, Chan DW, Park JH, Oettinger MA, Kwon J
Nucleic Acids Res. 2003
PubMed ID: 14627815
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Role of gamma delta T cells in the inflammatory response of experimental colitis mice.
Tsuchiya T, Fukuda S, Hamada H, Nakamura A, Kohama Y, Ishikawa H, Tsujikawa K, Yamamoto H
J Immunol. 2003
PubMed ID: 14607957
Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1.
Schild-Poulter C, Shih A, Yarymowich NC, Haché RJ
Cancer Res. 2003
PubMed ID: 14612514
Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: a new experimental model of diabetic autonomic neuropathy.
Schmidt RE, Dorsey DA, Beaudet LN, Frederick KE, Parvin CA, Plurad SB, Levisetti MG
Am J Pathol. 2003
PubMed ID: 14578206
Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma.
Shintani S, Mihara M, Li C, Nakahara Y, Hino S, Nakashiro K, Hamakawa H
Cancer Sci. 2003
PubMed ID: 14556663
Variations in Prkdc and susceptibility to benzene-induced toxicity in mice.
Faiola B, Bauer AK, Fuller ES, Wong VA, Pluta LJ, Abernethy DJ, Mangum JB, Everitt JI, Recio L
Toxicol Sci. 2003
PubMed ID: 12857942
Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.
Iwai H, Abe M, Hirose S, Tsushima F, Tezuka K, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M
J Immunol. 2003
PubMed ID: 12960306
Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex.
Goudelock DM, Jiang K, Pereira E, Russell B, Sanchez Y
J Biol Chem. 2003
PubMed ID: 12756247
Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.
Ding Q, Reddy YV, Wang W, Woods T, Douglas P, Ramsden DA, Lees-Miller SP, Meek K
Mol Cell Biol. 2003
PubMed ID: 12897153
Role of mammalian Rad54 in telomere length maintenance.
Jaco I, Muñoz P, Goytisolo F, Wesoly J, Bailey S, Taccioli G, Blasco MA
Mol Cell Biol. 2003
PubMed ID: 12897131
Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model.
Hiramatsu H, Nishikomori R, Heike T, Ito M, Kobayashi K, Katamura K, Nakahata T
Blood. 2003
PubMed ID: 12689924
Novel localization of the DNA-PK complex in lipid rafts: a putative role in the signal transduction pathway of the ionizing radiation response.
Lucero H, Gae D, Taccioli GE
J Biol Chem. 2003
PubMed ID: 12672807
Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility.
Fu YP, Yu JC, Cheng TC, Lou MA, Hsu GC, Wu CY, Chen ST, Wu HS, Wu PE, Shen CY
Cancer Res. 2003
PubMed ID: 12750264
BALB/c alleles for Prkdc and Cdkn2a interact to modify tumor susceptibility in Trp53+/- mice.
Blackburn AC, Brown JS, Naber SP, Otis CN, Wood JT, Jerry DJ
Cancer Res. 2003
PubMed ID: 12750252
Adenoma multiplicity in irradiated Apc(Min) mice is modified by chromosome 16 segments from BALB/c.
Degg NL, Weil MM, Edwards A, Haines J, Coster M, Moody J, Ellender M, Cox R, Silver A
Cancer Res. 2003
PubMed ID: 12750251
CTG repeat instability and size variation timing in DNA repair-deficient mice.
Savouret C, Brisson E, Essers J, Kanaar R, Pastink A, te Riele H, Junien C, Gourdon G
EMBO J. 2003
PubMed ID: 12727892
The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes.
Alugupalli KR, Gerstein RM, Chen J, Szomolanyi-Tsuda E, Woodland RT, Leong JM
J Immunol. 2003
PubMed ID: 12646649
Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase.
Ko L, Chin WW
J Biol Chem. 2003
PubMed ID: 12519782
The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets.
Hemmi H, Kaisho T, Takeda K, Akira S
J Immunol. 2003
PubMed ID: 12626561
Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells.
Haks MC, Belkowski SM, Ciofani M, Rhodes M, Lefebvre JM, Trop S, Hugo P, Zúñiga-Pflücker JC, Wiest DL
J Immunol. 2003
PubMed ID: 12626535
T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice.
Dohi T, Fujihashi K, Koga T, Shirai Y, Kawamura YI, Ejima C, Kato R, Saitoh K, McGhee JR
Gastroenterology. 2003
PubMed ID: 12612906
Function of DNA-protein kinase catalytic subunit during the early meiotic prophase without Ku70 and Ku86.
Hamer G, Roepers-Gajadien HL, van Duyn-Goedhart A, Gademan IS, Kal HB, van Buul PP, Ashley T, de Rooij DG
Biol Reprod. 2003
PubMed ID: 12604618
Engraftment of human CD34+ cells leads to widespread distribution of donor-derived cells and correction of tissue pathology in a novel murine xenotransplantation model of lysosomal storage disease.
Hofling AA, Vogler C, Creer MH, Sands MS
Blood. 2003
PubMed ID: 12406886
Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.
Calsou P, Delteil C, Frit P, Drouet J, Salles B
J Mol Biol. 2003
PubMed ID: 12547193
The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice.
Gladdy RA, Taylor MD, Williams CJ, Grandal I, Karaskova J, Squire JA, Rutka JT, Guidos CJ, Danska JS
Cancer Cell. 2003
PubMed ID: 12559174
IL-2 gene knockout affects T lymphocyte trafficking and the microglial response to regenerating facial motor neurons.
Petitto JM, Huang Z, Lo J, Streit WJ
J Neuroimmunol. 2003
PubMed ID: 12507776
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
DNA-dependent protein kinase activity is not required for immunoglobulin class switching.
Bosma GC, Kim J, Urich T, Fath DM, Cotticelli MG, Ruetsch NR, Radic MZ, Bosma MJ
J Exp Med. 2002
PubMed ID: 12461083
Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis.
Fiorucci S, Mencarelli A, Palazzetti B, Sprague AG, Distrutti E, Morelli A, Novobrantseva TI, Cirino G, Koteliansky VE, de Fougerolles AR
Immunity. 2002
PubMed ID: 12479823
Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice.
Engle SJ, Ormsby I, Pawlowski S, Boivin GP, Croft J, Balish E, Doetschman T
Cancer Res. 2002
PubMed ID: 12438215
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
Espejel S, Franco S, Sgura A, Gae D, Bailey SM, Taccioli GE, Blasco MA
EMBO J. 2002
PubMed ID: 12426399
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.
Douglas P, Sapkota GP, Morrice N, Yu Y, Goodarzi AA, Merkle D, Meek K, Alessi DR, Lees-Miller SP
Biochem J. 2002
PubMed ID: 12186630
Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.
Khaled AR, Li WQ, Huang J, Fry TJ, Khaled AS, Mackall CL, Muegge K, Young HA, Durum SK
Immunity. 2002
PubMed ID: 12433363
NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells.
Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K, Ueyama Y, Koyanagi Y, Sugamura K, Tsuji K, Heike T, Nakahata T
Blood. 2002
PubMed ID: 12384415
A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.
Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T
J Biol Chem. 2002
PubMed ID: 12171929
The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation.
Merkle D, Douglas P, Moorhead GB, Leonenko Z, Yu Y, Cramb D, Bazett-Jones DP, Lees-Miller SP
Biochemistry. 2002
PubMed ID: 12379113
Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2.
Wigginton JM, Lee JK, Wiltrout TA, Alvord WG, Hixon JA, Subleski J, Back TC, Wiltrout RH
J Immunol. 2002
PubMed ID: 12370382
Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication.
Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M
Biochim Biophys Acta. 2002
PubMed ID: 12393188
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.
Chan DW, Chen BP, Prithivirajsingh S, Kurimasa A, Story MD, Qin J, Chen DJ
Genes Dev. 2002
PubMed ID: 12231622
Radiation-induced apoptosis in the scid mouse spleen after low dose-rate irradiation.
Takahashi A, Asakawa I, Yuki K, Matsumoto T, Kumamoto M, Kondo N, Ohnishi K, Tachibana A, Ohnishi T
Int J Radiat Biol. 2002
PubMed ID: 12194752
The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis.
Kagari T, Doi H, Shimozato T
J Immunol. 2002
PubMed ID: 12133972
Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1.
Inamdar KV, Pouliot JJ, Zhou T, Lees-Miller SP, Rasouli-Nia A, Povirk LF
J Biol Chem. 2002
PubMed ID: 12023295
Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation.
Ishii KJ, Takeshita F, Gursel I, Gursel M, Conover J, Nussenzweig A, Klinman DM
J Exp Med. 2002
PubMed ID: 12119352
Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice.
Yahata T, Ando K, Nakamura Y, Ueyama Y, Shimamura K, Tamaoki N, Kato S, Hotta T
J Immunol. 2002
PubMed ID: 12077246
Synapsis of DNA ends by DNA-dependent protein kinase.
DeFazio LG, Stansel RM, Griffith JD, Chu G
EMBO J. 2002
PubMed ID: 12065431
DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53.
Woo RA, Jack MT, Xu Y, Burma S, Chen DJ, Lee PW
EMBO J. 2002
PubMed ID: 12065413
Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.
Yoshida M, Hosoi Y, Miyachi H, Ishii N, Matsumoto Y, Enomoto A, Nakagawa K, Yamada S, Suzuki N, Ono T
Int J Radiat Biol. 2002
PubMed ID: 12065055
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation.
Karmakar P, Piotrowski J, Brosh RM, Sommers JA, Miller SP, Cheng WH, Snowden CM, Ramsden DA, Bohr VA
J Biol Chem. 2002
PubMed ID: 11889123
IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells.
Manis JP, Dudley D, Kaylor L, Alt FW
Immunity. 2002
PubMed ID: 11970883
A role for antibody and Fc receptor in the clearance of Brugia malayi microfilariae.
Gray CA, Lawrence RA
Eur J Immunol. 2002
PubMed ID: 11920579
Defining interactions between DNA-PK and ligase IV/XRCC4.
Hsu HL, Yannone SM, Chen DJ
DNA Repair (Amst). 2002
PubMed ID: 12509254
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination.
Ma Y, Pannicke U, Schwarz K, Lieber MR
Cell. 2002
PubMed ID: 11955432
DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination.
Allen C, Kurimasa A, Brenneman MA, Chen DJ, Nickoloff JA
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11904432
Homeostatic regulation of intestinal villous epithelia by B lymphocytes.
Nishiyama Y, Hamada H, Nonaka S, Yamamoto H, Nanno M, Katayama Y, Takahashi H, Ishikawa H
J Immunol. 2002
PubMed ID: 11884426
Interferon regulatory factor-3 is an in vivo target of DNA-PK.
Karpova AY, Trost M, Murray JM, Cantley LC, Howley PM
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11867762
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.
Barcia R, López-Borges S, Vega FM, Lazo PA
Arch Biochem Biophys. 2002
PubMed ID: 11883897
Sequence analysis of 193.4 and 83.9 kbp of mouse and chicken genomic DNAs containing the entire Prkdc (DNA-PKcs) gene.
Fujimori A, Hashimoto H, Araki R, Saito T, Sato S, Kasama Y, Tsutsumi Y, Mori M, Fukumura R, Ohhata T, Tatsumi K, Abe M
Radiat Res. 2002
PubMed ID: 11839092
DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia.
Ding Q, Bramble L, Yuzbasiyan-Gurkan V, Bell T, Meek K
Gene. 2002
PubMed ID: 11867233
Directed proteomic analysis of the human nucleolus.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI
Curr Biol. 2002
PubMed ID: 11790298
DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX).
Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U
J Cell Sci. 2002
PubMed ID: 11801738
The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells.
Reichman TW, Muñiz LC, Mathews MB
Mol Cell Biol. 2002
PubMed ID: 11739746
DNA-PKcs is critical for telomere capping.
Gilley D, Tanaka H, Hande MP, Kurimasa A, Li GC, Oshimura M, Chen DJ
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11742099
Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells.
Pierce AJ, Hu P, Han M, Ellis N, Jasin M
Genes Dev. 2001
PubMed ID: 11751629
Mycobacterium avium subspecies paratuberculosis triggers intestinal pathophysiologic changes in beige/scid mice.
Mutwiri GK, Kosecka U, Benjamin M, Rosendal S, Perdue M, Butler DG
Comp Med. 2001
PubMed ID: 11924817
Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.
Wang H, Guan J, Wang H, Perrault AR, Wang Y, Iliakis G
Cancer Res. 2001
PubMed ID: 11731442
Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.
Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W
J Biol Chem. 2001
PubMed ID: 11551930
UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts.
Latonen L, Taya Y, Laiho M
Oncogene. 2001
PubMed ID: 11709713
Involvement of DNA-dependent protein kinase in regulation of stress-induced JNK activation.
Park SJ, Oh EJ, Yoo MA, Lee SH
DNA Cell Biol. 2001
PubMed ID: 11749722
High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase.
Ochiai M, Ubagai T, Kawamori T, Imai H, Sugimura T, Nakagama H
Carcinogenesis. 2001
PubMed ID: 11532879
Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons.
Binder GK, Griffin DE
Science. 2001
PubMed ID: 11452126
A cutaneous gene therapy approach to human leptin deficiencies: correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts.
Larcher F, Del Rio M, Serrano F, Segovia JC, Ramírez A, Meana A, Page A, Abad JL, González MA, Bueren J, Bernad A, Jorcano JL
FASEB J. 2001
PubMed ID: 11427484
Frameshift mutation in PRKDC, the gene for DNA-PKcs, in the DNA repair-defective, human, glioma-derived cell line M059J.
Anderson CW, Dunn JJ, Freimuth PI, Galloway AM, Allalunis-Turner MJ
Radiat Res. 2001
PubMed ID: 11418067
Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection.
Li L, Olvera JM, Yoder KE, Mitchell RS, Butler SL, Lieber M, Martin SL, Bushman FD
EMBO J. 2001
PubMed ID: 11406603
The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice.
Eaton KA, Mefford M, Thevenot T
J Immunol. 2001
PubMed ID: 11390498
The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.
Goytisolo FA, Samper E, Edmonson S, Taccioli GE, Blasco MA
Mol Cell Biol. 2001
PubMed ID: 11340158
The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase.
Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M, Haché RJ
J Biol Chem. 2001
PubMed ID: 11279128
Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and -/- mice.
Ganley L, Babu S, Rajan TV
Exp Parasitol. 2001
PubMed ID: 11426950
Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.
Sekiguchi J, Ferguson DO, Chen HT, Yang EM, Earle J, Frank K, Whitlow S, Gu Y, Xu Y, Nussenzweig A, Alt FW
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11248063
Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity.
Culmsee C, Bondada S, Mattson MP
Brain Res Mol Brain Res. 2001
PubMed ID: 11245929
Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice.
Vemuri MC, Schiller E, Naegele JR
Cell Death Differ. 2001
PubMed ID: 11319607
Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA-dependent protein kinase catalytic subunit) gene.
Yu Y, Okayasu R, Weil MM, Silver A, McCarthy M, Zabriskie R, Long S, Cox R, Ullrich RL
Cancer Res. 2001
PubMed ID: 11280730
Development of the tight-skin phenotype in immune-deficient mice.
Dodig TD, Mack KT, Cassarino DF, Clark SH
Arthritis Rheum. 2001
PubMed ID: 11263788
EBNA-LP associates with cellular proteins including DNA-PK and HA95.
Han I, Harada S, Weaver D, Xue Y, Lane W, Orstavik S, Skalhegg B, Kieff E
J Virol. 2001
PubMed ID: 11160753
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis.
Gurley KE, Kemp CJ
Curr Biol. 2001
PubMed ID: 11231155
Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.
Daniel R, Katz RA, Merkel G, Hittle JC, Yen TJ, Skalka AM
Mol Cell Biol. 2001
PubMed ID: 11158303
Lack of B cell leakiness in BALB/cA-nu, scid double mutant mice.
Hioki K, Kuramochi T, Endoh S, Terada E, Ueyama Y, Ito M
Exp Anim. 2001
PubMed ID: 11326425
Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice.
Glimm H, Eisterer W, Lee K, Cashman J, Holyoake TL, Nicolini F, Shultz LD, von Kalle C, Eaves CJ
J Clin Invest. 2001
PubMed ID: 11160136
Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4, KO, and CD8 KO mice.
Bumgardner GL, Gao D, Li J, Baskin JH, Heininger M, Orosz CG
Transplantation. 2000
PubMed ID: 11152110
Characterization of lymphocyte-dependent angiogenesis using a SCID mouse: human skin model of psoriasis.
Nickoloff BJ
J Investig Dermatol Symp Proc. 2000
PubMed ID: 11147678
Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.
Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI
EMBO J. 2000
PubMed ID: 11101529
Cutaneous inflammatory disorder in integrin alphaE (CD103)-deficient mice.
Schön MP, Schön M, Warren HB, Donohue JP, Parker CM
J Immunol. 2000
PubMed ID: 11086102
DNA-Dependent protein kinase is not required for efficient lentivirus integration.
Baekelandt V, Claeys A, Cherepanov P, De Clercq E, De Strooper B, Nuttin B, Debyser Z
J Virol. 2000
PubMed ID: 11070027
Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.
Zhou P, Szot GL, Guo Z, Kim O, He G, Wang J, Grusby MJ, Newell KA, Thistlethwaite JR, Bluestone JA, Alegre ML
J Immunol. 2000
PubMed ID: 11067913
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response.
Brush GS, Kelly TJ
Nucleic Acids Res. 2000
PubMed ID: 11000264
Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair.
Hanakahi LA, Bartlet-Jones M, Chappell C, Pappin D, West SC
Cell. 2000
PubMed ID: 11030616
Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice.
Hayward AR, Chmura K, Cosyns M
J Infect Dis. 2000
PubMed ID: 10950807
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.
Lopez-Borges S, Lazo PA
Oncogene. 2000
PubMed ID: 10951572
Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy.
Ashkar AA, Di Santo JP, Croy BA
J Exp Med. 2000
PubMed ID: 10899912
Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice.
Smythies LE, Waites KB, Lindsey JR, Harris PR, Ghiara P, Smith PD
J Immunol. 2000
PubMed ID: 10878379
A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity.
Belkaid Y, Mendez S, Lira R, Kadambi N, Milon G, Sacks D
J Immunol. 2000
PubMed ID: 10878373
Delayed wound healing in immunodeficient TGF-beta 1 knockout mice.
Crowe MJ, Doetschman T, Greenhalgh DG
J Invest Dermatol. 2000
PubMed ID: 10886500
Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: toward tolerance induction across discordant xenogeneic barriers.
Chen AM, Zhou Y, Swenson K, Sachs DH, Sykes M, Yang YG
Transplantation. 2000
PubMed ID: 10910267
Unexpected rearrangement and expression of the immunoglobulin lambda1 locus in scid mice.
Ruetsch NR, Bosma GC, Bosma MJ
J Exp Med. 2000
PubMed ID: 10839808
Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase.
Sayed M, Kim SO, Salh BS, Issinger OG, Pelech SL
J Biol Chem. 2000
PubMed ID: 10747897
Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction.
Lode HN, Xiang R, Pertl U, Förster E, Schoenberger SP, Gillies SD, Reisfeld RA
J Clin Invest. 2000
PubMed ID: 10841521
The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase.
Jhappan C, Yusufzai TM, Anderson S, Anver MR, Merlino G
Mol Cell Biol. 2000
PubMed ID: 10805749
Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.
Ko L, Cardona GR, Chin WW
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10823961
Development of intermediate-grade (mantle cell) and low-grade (small lymphocytic and marginal zone) human non-Hodgkin's lymphomas xenotransplanted in severe combined immunodeficiency mouse models.
Bryant J, Pham L, Yoshimura L, Tamayo A, Ordonez N, Ford RJ
Lab Invest. 2000
PubMed ID: 10780672
Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial T cells.
Oida T, Suzuki K, Nanno M, Kanamori Y, Saito H, Kubota E, Kato S, Itoh M, Kaminogawa S, Ishikawa H
J Immunol. 2000
PubMed ID: 10725718
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
Role of B cells in maintaining helper T-cell memory.
van Essen D, Dullforce P, Gray D
Philos Trans R Soc Lond B Biol Sci. 2000
PubMed ID: 10794053
Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.
Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10716994
B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites.
Paciorkowski N, Porte P, Shultz LD, Rajan TV
J Exp Med. 2000
PubMed ID: 10684864
The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest.
Wang S, Guo M, Ouyang H, Li X, Cordon-Cardo C, Kurimasa A, Chen DJ, Fuks Z, Ling CC, Li GC
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10677503
Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier.
Yang YG, Chen AM, Garrett LJ, Sergio JJ, Theodore P, Awwad M, VerHalen J, Bodine DM, Sachs DH, Sykes M
Xenotransplantation. 2000
PubMed ID: 10809058
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.
Shieh SY, Ahn J, Tamai K, Taya Y, Prives C
Genes Dev. 2000
PubMed ID: 10673501
Substrate specificities and identification of putative substrates of ATM kinase family members.
Kim ST, Lim DS, Canman CE, Kastan MB
J Biol Chem. 1999
PubMed ID: 10608806
A comparative gene map of the horse (Equus caballus).
Caetano AR, Shiue YL, Lyons LA, O'Brien SJ, Laughlin TF, Bowling AT, Murray JD
Genome Res. 1999
PubMed ID: 10613847
The SCID mouse: an experimental model for endometriosis.
Awwad JT, Sayegh RA, Tao XJ, Hassan T, Awwad ST, Isaacson K
Hum Reprod. 1999
PubMed ID: 10601104
Irradiation-induced rescue of thymocyte differentiation and V(D)J recombination in mice lacking the catalytic subunit of DNA-dependent protein kinase.
Wang C, Bogue MA, Nguyen AP, Roth DB
J Immunol. 1999
PubMed ID: 10570295
Functional regulation of L-type calcium channels via protein kinase A-mediated phosphorylation of the beta(2) subunit.
Bünemann M, Gerhardstein BL, Gao T, Hosey MM
J Biol Chem. 1999
PubMed ID: 10567342
Dendritic cells require T cells for functional maturation in vivo.
Shreedhar V, Moodycliffe AM, Ullrich SE, Bucana C, Kripke ML, Flores-Romo L
Immunity. 1999
PubMed ID: 10591187
Differential subcellular localization of DNA-dependent protein kinase components Ku and DNA-PKcs during mitosis.
Koike M, Awaji T, Kataoka M, Tsujimoto G, Kartasova T, Koike A, Shiomi T
J Cell Sci. 1999
PubMed ID: 10547363
Resistance to skin tumorigenesis in DNAPK-deficient SCID mice is not due to immunodeficiency but results from hypersensitivity to TPA-induced apoptosis.
Kemp CJ, Vo K, Gurley KE
Carcinogenesis. 1999
PubMed ID: 10545405
Irradiation-mediated rescue of T cell-specific V(D)J recombination and thymocyte differentiation in severe combined immunodeficient mice by bone marrow cells.
Wang C, Bogue MA, Levitt JM, Roth DB
J Exp Med. 1999
PubMed ID: 10544197
Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation.
Suzuki K, Kodama S, Watanabe M
J Biol Chem. 1999
PubMed ID: 10464290
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex.
Gell D, Jackson SP
Nucleic Acids Res. 1999
PubMed ID: 10446239
Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro.
Ariumi Y, Masutani M, Copeland TD, Mimori T, Sugimura T, Shimotohno K, Ueda K, Hatanaka M, Noda M
Oncogene. 1999
PubMed ID: 10467406
Identification of the sites phosphorylated by cyclic AMP-dependent protein kinase on the beta 2 subunit of L-type voltage-dependent calcium channels.
Gerhardstein BL, Puri TS, Chien AJ, Hosey MM
Biochemistry. 1999
PubMed ID: 10441130
Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells.
Haks MC, Krimpenfort P, van den Brakel JH, Kruisbeek AM
Immunity. 1999
PubMed ID: 10435582
DNA-dependent protein kinase-independent activation of p53 in response to DNA damage.
Burma S, Kurimasa A, Xie G, Taya Y, Araki R, Abe M, Crissman HA, Ouyang H, Li GC, Chen DJ
J Biol Chem. 1999
PubMed ID: 10358069
Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) mice.
Serpe CJ, Kohm AP, Huppenbauer CB, Sanders VM, Jones KJ
J Neurosci. 1999
PubMed ID: 10341268
Phosphorylation by DNAPK inhibits the DNA-binding function of p53/T antigen complex in vitro.
Sheppard HM, Liu X
Anticancer Res. 1999
PubMed ID: 10470151
Sequence-ready physical map of the mouse chromosome 16 region with conserved synteny to the human velocardiofacial syndrome region on 22q11.2.
Lund J, Roe B, Chen F, Budarf M, Galili N, Riblet R, Miller RD, Emanuel BS, Reeves RH
Mamm Genome. 1999
PubMed ID: 10337614
Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells.
Emoto M, Mittrücker HW, Schmits R, Mak TW, Kaufmann SH
J Immunol. 1999
PubMed ID: 10227978
The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit.
Singleton BK, Torres-Arzayus MI, Rottinghaus ST, Taccioli GE, Jeggo PA
Mol Cell Biol. 1999
PubMed ID: 10207052
A role for DNA-PK in retroviral DNA integration.
Daniel R, Katz RA, Skalka AM
Science. 1999
PubMed ID: 10213687
Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo.
Fernandez NC, Lozier A, Flament C, Ricciardi-Castagnoli P, Bellet D, Suter M, Perricaudet M, Tursz T, Maraskovsky E, Zitvogel L
Nat Med. 1999
PubMed ID: 10202929
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.
Shao RG, Cao CX, Zhang H, Kohn KW, Wold MS, Pommier Y
EMBO J. 1999
PubMed ID: 10064605
Elongated telomeres in scid mice.
Hande P, Slijepcevic P, Silver A, Bouffler S, van Buul P, Bryant P, Lansdorp P
Genomics. 1999
PubMed ID: 10051409
Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.
Kurimasa A, Ouyang H, Dong LJ, Wang S, Li X, Cordon-Cardo C, Chen DJ, Li GC
Proc Natl Acad Sci U S A. 1999
PubMed ID: 9990036
DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer.
Chan DW, Ye R, Veillette CJ, Lees-Miller SP
Biochemistry. 1999
PubMed ID: 10026262
Mutations in the p53 and scid genes do not cooperate in lymphomagenesis in doubly heterozygous mice.
Kosugi S, Miyazawa T, Chou D, Saito Y, Shinbo T, Matsuki A, Okano H, Miyaji C, Watanabe H, Hatakeyama K, Niwa O, Kominami R
Biochem Biophys Res Commun. 1999
PubMed ID: 10082662
The Ku70 autoantigen interacts with p40phox in B lymphocytes.
Grandvaux N, Grizot S, Vignais PV, Dagher MC
J Cell Sci. 1999
PubMed ID: 9914162
Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors.
Gallo-Hendrikx E, Percy D, Copps J, McKeown B, Quinton M, McMillan I, Croy BA, Wildeman AG
APMIS. 1999
PubMed ID: 10225324
IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-gamma.
Hoshino T, Winkler-Pickett RT, Mason AT, Ortaldo JR, Young HA
J Immunol. 1999
PubMed ID: 9886369
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation.
Bogue MA, Jhappan C, Roth DB
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9861008
Resistance to the African trypanosomes is IFN-gamma dependent.
Hertz CJ, Filutowicz H, Mansfield JM
J Immunol. 1998
PubMed ID: 9862708
Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas.
Fogler WE, Volker K, Watanabe M, Wigginton JM, Roessler P, Brunda MJ, Ortaldo JR, Wiltrout RH
J Immunol. 1998
PubMed ID: 9834083
Inappropriate apoptosis of salivary and lacrimal gland epithelium of immunodeficient NOD-scid mice.
Kong L, Robinson CP, Peck AB, Vela-Roch N, Sakata KM, Dang H, Talal N, Humphreys-Beher MG
Clin Exp Rheumatol. 1998
PubMed ID: 9844759
Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis.
Bharti A, Kraeft SK, Gounder M, Pandey P, Jin S, Yuan ZM, Lees-Miller SP, Weichselbaum R, Weaver D, Chen LB, Kufe D, Kharbanda S
Mol Cell Biol. 1998
PubMed ID: 9774685
Regulation of DNA-dependent protein kinase by the Lyn tyrosine kinase.
Kumar S, Pandey P, Bharti A, Jin S, Weichselbaum R, Weaver D, Kufe D, Kharbanda S
J Biol Chem. 1998
PubMed ID: 9748231
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.
Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE, Abraham RT
Cancer Res. 1998
PubMed ID: 9766667
The complexity of p53 modulation: emerging patterns from divergent signals.
Giaccia AJ, Kastan MB
Genes Dev. 1998
PubMed ID: 9765199
A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination.
Gao Y, Chaudhuri J, Zhu C, Davidson L, Weaver DT, Alt FW
Immunity. 1998
PubMed ID: 9768756
Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity.
Taccioli GE, Amatucci AG, Beamish HJ, Gell D, Xiang XH, Torres Arzayus MI, Priestley A, Jackson SP, Marshak Rothstein A, Jeggo PA, Herrera VL
Immunity. 1998
PubMed ID: 9768755
Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor.
Stalder AK, Carson MJ, Pagenstecher A, Asensio VC, Kincaid C, Benedict M, Powell HC, Masliah E, Campbell IL
Am J Pathol. 1998
PubMed ID: 9736027
High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro.
Yumoto Y, Shirakawa H, Yoshida M, Suwa A, Watanabe F, Teraoka H
J Biochem. 1998
PubMed ID: 9722660
Mouse cdc21 only 0.5 kb upstream from dna-pkcs in a head-to-head organization: an implication of co-evolution of ATM family members and cell cycle regulating genes.
Saito T, Matsuda Y, Ishii H, Watanabe F, Mori M, Hayashi A, Araki R, Fujimori A, Fukumura R, Morimyo M, Tatsumi K, Hori T, Abe M
Mamm Genome. 1998
PubMed ID: 9716665
Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice.
Babu S, Porte P, Klei TR, Shultz LD, Rajan TV
J Immunol. 1998
PubMed ID: 9686607
Infection of the laboratory mouse with the intracellular pathogen Ehrlichia chaffeensis.
Winslow GM, Yager E, Shilo K, Collins DN, Chu FK
Infect Immun. 1998
PubMed ID: 9673277
DNA double-strand breaks, p53, and apoptosis during lymphomagenesis in scid/scid mice.
Gurley KE, Vo K, Kemp CJ
Cancer Res. 1998
PubMed ID: 9679979
DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D.
Yavuzer U, Smith GC, Bliss T, Werner D, Jackson SP
Genes Dev. 1998
PubMed ID: 9679063
Further characterization of the radiosensitivity of the scid mouse.
van Buul PP, Abramsson-Zetterberg L, Zandman IM, van Duyn-Goedhart A
Int J Radiat Biol. 1998
PubMed ID: 9687973
DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties.
Liu L, Kwak YT, Bex F, García-Martínez LF, Li XH, Meek K, Lane WS, Gaynor RB
Mol Cell Biol. 1998
PubMed ID: 9632806
Antibody-IL-12 fusion proteins are effective in SCID mouse models of prostate and colon carcinoma metastases.
Gillies SD, Lan Y, Wesolowski JS, Qian X, Reisfeld RA, Holden S, Super M, Lo KM
J Immunol. 1998
PubMed ID: 9637539
Developmental malformations and intrauterine deaths in gamma-ray-irradiated scid mouse embryos.
Shoji S, Watanabe H, Katoh O, Masaoka Y, Matsuura S, Tauchi H, Endo S, Komatsu K
Int J Radiat Biol. 1998
PubMed ID: 9690689
No requirement for V(D)J recombination in p53-deficient thymic lymphoma.
Liao MJ, Zhang XX, Hill R, Gao J, Qumsiyeh MB, Nichols W, Van Dyke T
Mol Cell Biol. 1998
PubMed ID: 9584189
Murine cell line SX9 bearing a mutation in the dna-pkcs gene exhibits aberrant V(D)J recombination not only in the coding joint but also in the signal joint.
Fukumura R, Araki R, Fujimori A, Mori M, Saito T, Watanabe F, Sarashi M, Itsukaichi H, Eguchi-Kasai K, Sato K, Tatsumi K, Abe M
J Biol Chem. 1998
PubMed ID: 9582343
Reduced joining of DNA double strand breaks with an abnormal mutation spectrum in rodent mutants of DNA-PKcs and Ku80.
Tzung TY, Rünger TM
Int J Radiat Biol. 1998
PubMed ID: 9652803
Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis.
Andrade F, Roy S, Nicholson D, Thornberry N, Rosen A, Casciola-Rosen L
Immunity. 1998
PubMed ID: 9586635
Modulation of Sp1 phosphorylation by human immunodeficiency virus type 1 Tat.
Chun RF, Semmes OJ, Neuveut C, Jeang KT
J Virol. 1998
PubMed ID: 9525578
Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex.
Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, Berger SL
Mol Cell Biol. 1998
PubMed ID: 9488450
DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45.
Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP
J Biol Chem. 1998
PubMed ID: 9442054
DNA-dependent protein kinase: DNA binding and activation in the absence of Ku.
Hammarsten O, Chu G
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9435225
The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase.
Leber R, Wise TW, Mizuta R, Meek K
J Biol Chem. 1998
PubMed ID: 9430729
Assignment of the ZIP kinase gene to human chromosome 19p13.3 by somatic hybrid analysis and fluorescence in-situ hybridization.
Saito T, Seki N, Ohira M, Hayashi A, Kozuma S, Hattori A, Hori T
J Hum Genet. 1998
PubMed ID: 9747039
The Xid defect imparts susceptibility to experimental murine filariosis--association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine.
Al-Qaoud KM, Fleischer B, Hoerauf A
Int Immunol. 1998
PubMed ID: 9488152
Increased intracellular Th1 cytokines in scid mice with inflammatory bowel disease.
Bregenholt S, Claesson MH
Eur J Immunol. 1998
PubMed ID: 9485217
Splenic T helper cell type 1 cytokine profile and extramedullary haematopoiesis in severe combined immunodeficient (scid) mice with inflammatory bowel disease (IBD).
Bregenholt S, Claesson MH
Clin Exp Immunol. 1998
PubMed ID: 9472677
A new chance for SCID gene therapy.
Bordignon C
Nat Med. 1998
PubMed ID: 9427599
A crucial role for B cells in neuroinvasive scrapie.
Klein MA, Frigg R, Flechsig E, Raeber AJ, Kalinke U, Bluethmann H, Bootz F, Suter M, Zinkernagel RM, Aguzzi A
Nature. 1997
PubMed ID: 9414161
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus.
Jhappan C, Morse HC, Fleischmann RD, Gottesman MM, Merlino G
Nat Genet. 1997
PubMed ID: 9398856
Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis.
Morrison C, Smith GC, Stingl L, Jackson SP, Wagner EF, Wang ZQ
Nat Genet. 1997
PubMed ID: 9398855
Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions.
Jin S, Weaver DT
EMBO J. 1997
PubMed ID: 9362500
Lymphocytes mediate TNF-alpha-induced endothelial cell adhesion molecule expression: studies on SCID and RAG-1 mutant mice.
Horie Y, Chervenak RP, Wolf R, Gerritsen ME, Anderson DC, Komatsu S, Granger DN
J Immunol. 1997
PubMed ID: 9366433
Growth retardation and leaky SCID phenotype of Ku70-deficient mice.
Gu Y, Seidl KJ, Rathbun GA, Zhu C, Manis JP, van der Stoep N, Davidson L, Cheng HL, Sekiguchi JM, Frank K, Stanhope-Baker P, Schlissel MS, Roth DB, Alt FW
Immunity. 1997
PubMed ID: 9390689
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2.
Shieh SY, Ikeda M, Taya Y, Prives C
Cell. 1997
PubMed ID: 9363941
Heat shock transcription factor 1 binds selectively in vitro to Ku protein and the catalytic subunit of the DNA-dependent protein kinase.
Huang J, Nueda A, Yoo S, Dynan WS
J Biol Chem. 1997
PubMed ID: 9325337
Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit.
Jin S, Kharbanda S, Mayer B, Kufe D, Weaver DT
J Biol Chem. 1997
PubMed ID: 9312071
Interaction between DNA-dependent protein kinase and a novel protein, KIP.
Wu X, Lieber MR
Mutat Res. 1997
PubMed ID: 9372844
The murine DNA-PKcs gene consists of 86 exons dispersed in more than 250 kb.
Fujimori A, Araki R, Fukumura R, Saito T, Mori M, Mita K, Tatsumi K, Abe M
Genomics. 1997
PubMed ID: 9339376
Cytotoxic T-cell-resistant variants arise at early times after infection in C57BL/6 but not in SCID mice infected with a neurotropic coronavirus.
Pewe L, Xue S, Perlman S
J Virol. 1997
PubMed ID: 9311846
Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells.
Zernik-Kobak M, Vasunia K, Connelly M, Anderson CW, Dixon K
J Biol Chem. 1997
PubMed ID: 9295339
bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8- T cell progenitors.
O'Reilly LA, Harris AW, Strasser A
Int Immunol. 1997
PubMed ID: 9310832
Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo.
O'Reilly LA, Harris AW, Tarlinton DM, Corcoran LM, Strasser A
J Immunol. 1997
PubMed ID: 9278319
Nonspecific immune responses and mechanisms of resistance to Eimeria papillata infections in mice.
Schito ML, Barta JR
Infect Immun. 1997
PubMed ID: 9234770
Human skin/SCID mouse chimeras as an in vivo model for human cutaneous mast cell hyperplasia.
Christofidou-Solomidou M, Longley BJ, Whitaker-Menezes D, Albelda SM, Murphy GF
J Invest Dermatol. 1997
PubMed ID: 9204963
Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection.
Doherty TM, Sher A
J Immunol. 1997
PubMed ID: 9144497
The Fas-deficient SCID mouse exhibits the development of T cells in the thymus.
Yasutomo K, Maeda K, Hisaeda H, Good RA, Kuroda Y, Himeno K
J Immunol. 1997
PubMed ID: 9144486
Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitro.
Niu H, Erdjument-Bromage H, Pan ZQ, Lee SH, Tempst P, Hurwitz J
J Biol Chem. 1997
PubMed ID: 9139719
Different developmental arrest points in RAG-2 -/- and SCID thymocytes on two genetic backgrounds: developmental choices and cell death mechanisms before TCR gene rearrangement.
Diamond RA, Ward SB, Owada-Makabe K, Wang H, Rothenberg EV
J Immunol. 1997
PubMed ID: 9126963
Functional interaction between DNA-PK and c-Abl in response to DNA damage.
Kharbanda S, Pandey P, Jin S, Inoue S, Bharti A, Yuan ZM, Weichselbaum R, Weaver D, Kufe D
Nature. 1997
PubMed ID: 9109492
Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice.
Christianson SW, Greiner DL, Hesselton RA, Leif JH, Wagar EJ, Schweitzer IB, Rajan TV, Gott B, Roopenian DC, Shultz LD
J Immunol. 1997
PubMed ID: 9103418
SCID-bg mice as xenograft recipients.
Shibata S, Asano T, Ogura A, Hashimoto N, Hayakawa J, Uetsuka K, Nakayama H, Doi K
Lab Anim. 1997
PubMed ID: 9175014
IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi.
Hunter CA, Ellis-Neyes LA, Slifer T, Kanaly S, Grünig G, Fort M, Rennick D, Araujo FG
J Immunol. 1997
PubMed ID: 9120288
Studies of the susceptibility of nude, CD4 knockout, and SCID mutant mice to the disease induced by the murine AIDS defective virus.
Simard C, Klein SJ, Mak T, Jolicoeur P
J Virol. 1997
PubMed ID: 9060661
Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice.
Araki R, Fujimori A, Hamatani K, Mita K, Saito T, Mori M, Fukumura R, Morimyo M, Muto M, Itoh M, Tatsumi K, Abe M
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9122213
Effect of different Ig transgenes on B cell differentiation in scid mice.
Chang Y, Bosma MJ
Int Immunol. 1997
PubMed ID: 9088976
Sequence-specific DNA binding and transcription factor phosphorylation by Ku Autoantigen/DNA-dependent protein kinase. Phosphorylation of Ser-527 of the rat glucocorticoid receptor.
Giffin W, Kwast-Welfeld J, Rodda DJ, Préfontaine GG, Traykova-Andonova M, Zhang Y, Weigel NL, Lefebvre YA, Haché RJ
J Biol Chem. 1997
PubMed ID: 9038175
Immunodeficient and immunosuppressed mice as models to test anti-Pneumocystis carinii drugs.
Walzer PD, Runck J, Steele P, White M, Linke MJ, Sidman CL
Antimicrob Agents Chemother. 1997
PubMed ID: 9021175
Interleukin-6 overexpression cannot generate serious disorders in severe combined immunodeficiency mice.
Katsume A, Miyai T, Suzuki H, Moriguchi Y, Kawata H, Tatsumi T, Suematsu S, Kishimoto T, Ohsugi Y
Clin Immunol Immunopathol. 1997
PubMed ID: 9000479
MCM4 and PRKDC, human genes encoding proteins MCM4 and DNA-PKcs, are close neighbours located on chromosome 8q12-->q13.
Ladenburger EM, Fackelmayer FO, Hameister H, Knippers R
Cytogenet Cell Genet. 1997
PubMed ID: 9284934
Protective immunity to HIV-1 in SCID/beige mice reconstituted with peripheral blood lymphocytes of exposed but uninfected individuals.
Zhang C, Cui Y, Houston S, Chang LJ
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8962121
p53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice.
Gurley KE, Kemp CJ
Carcinogenesis. 1996
PubMed ID: 9006086
The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.
Fried LM, Koumenis C, Peterson SR, Green SL, van Zijl P, Allalunis-Turner J, Chen DJ, Fishel R, Giaccia AJ, Brown JM, Kirchgessner CU
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8943020
Alternate splice-site utilization in the gene for the catalytic subunit of the DNA-activated protein kinase, DNA-PKcs.
Connelly MA, Zhang H, Kieleczawa J, Anderson CW
Gene. 1996
PubMed ID: 8917110
The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.
Rolink A, Melchers F, Andersson J
Immunity. 1996
PubMed ID: 8885865
Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes.
Danska JS, Holland DP, Mariathasan S, Williams KM, Guidos CJ
Mol Cell Biol. 1996
PubMed ID: 8816463
Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.
Blunt T, Gell D, Fox M, Taccioli GE, Lehmann AR, Jackson SP, Jeggo PA
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8816792
CPP32/Yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme.
Teraoka H, Yumoto Y, Watanabe F, Tsukada K, Suwa A, Enari M, Nagata S
FEBS Lett. 1996
PubMed ID: 8804412
Mutations in the p53 and SCID genes cooperate in tumorigenesis.
Nacht M, Strasser A, Chan YR, Harris AW, Schlissel M, Bronson RT, Jacks T
Genes Dev. 1996
PubMed ID: 8769648
V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.
Guidos CJ, Williams CJ, Grandal I, Knowles G, Huang MT, Danska JS
Genes Dev. 1996
PubMed ID: 8769647
Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice.
Christianson SW, Greiner DL, Schweitzer IB, Gott B, Beamer GL, Schweitzer PA, Hesselton RM, Shultz LD
Cell Immunol. 1996
PubMed ID: 8806787
Dysfunctional cytokine receptor signaling in severe combined immunodeficiency.
Leonard WJ
J Investig Med. 1996
PubMed ID: 8795294
Normal D-JH rearranged products of the IgH gene in SCID mouse bone marrow.
Araki R, Itoh M, Hamatani K, Abe M
Int Immunol. 1996
PubMed ID: 8757950
Effect of the mouse scid mutation on meiotic recombination.
Heine D, Passmore HC, Patel V, Shultz LD, Ward-Bailey P, Cook SA, Davisson MT
Mamm Genome. 1996
PubMed ID: 8672126
Preferential hematopoiesis by paroxysmal nocturnal hemoglobinuria clone engrafted in SCID mice.
Iwamoto N, Kawaguchi T, Horikawa K, Nagakura S, Kagimoto T, Suda T, Takatsuki K, Nakakuma H
Blood. 1996
PubMed ID: 8652806
Transfer of type II collagen-induced arthritis from DBA/1 to severe combined immunodeficiency mice can be prevented by blockade of Mac-1.
Taylor PC, Chu CQ, Plater-Zyberk C, Maini RN
Immunology. 1996
PubMed ID: 8690467
Ability of spleen, peritoneal cavity, and lymph node B cells to reconstitute serum immunoglobulin in SCID mice.
Riggs J, Stowers R
Immunology. 1996
PubMed ID: 8707345
p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes.
Bogue MA, Zhu C, Aguilar-Cordova E, Donehower LA, Roth DB
Genes Dev. 1996
PubMed ID: 8598286
Nitric oxide and host defense against Pneumocystis carinii infection in a mouse model.
Shellito JE, Kolls JK, Olariu R, Beck JM
J Infect Dis. 1996
PubMed ID: 8568306
Frequency and histological appearance of adenomas in multiple intestinal neoplasia mice are unaffected by severe combined immunodeficiency (scid) mutation.
Dudley ME, Sundberg JP, Roopenian DC
Int J Cancer. 1996
PubMed ID: 8567125
Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta.
Chan DW, Mody CH, Ting NS, Lees-Miller SP
Biochem Cell Biol. 1996
PubMed ID: 9035691
Cloning and chromosomal mapping of the mouse DNA-dependent protein kinase gene.
Hamatani K, Matsuda Y, Araki R, Itoh M, Abe M
Immunogenetics. 1996
PubMed ID: 8881030
Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes.
Li T, Ramirez K, Palacios R
Cell Growth Differ. 1996
PubMed ID: 8788039
Translocation of bacteria from the gastrointestinal tract in immunodeficient mice.
Ohsugi T, Kiuchi Y, Shimoda K, Oguri S, Maejima K
Lab Anim. 1996
PubMed ID: 8709573
Insertional mutagenesis affecting programmed cell death leads to thymic hyperplasia and altered thymopoiesis.
Volkmann A, Döffinger R, Rüther U, Kyewski BA
J Immunol. 1996
PubMed ID: 8598454
Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells.
Serreze DV, Leiter EH, Hanson MS, Christianson SW, Shultz LD, Hesselton RM, Greiner DL
Diabetes. 1995
PubMed ID: 7589844
Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases.
Poltoratsky VP, Shi X, York JD, Lieber MR, Carter TH
J Immunol. 1995
PubMed ID: 7594449
Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.
Miller RD, Hogg J, Ozaki JH, Gell D, Jackson SP, Riblet R
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7479885
Prevention of adoptive transfer of murine Sjögren's syndrome into severe combined immunodeficient (SCID) mice by antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1).
Hayashi Y, Haneji N, Yanagi K, Higashiyama H, Yagita H, Hamano H
Clin Exp Immunol. 1995
PubMed ID: 7586691
High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice.
Hesselton RM, Greiner DL, Mordes JP, Rajan TV, Sullivan JL, Shultz LD
J Infect Dis. 1995
PubMed ID: 7561218
Graves' disease in severe combined immunodeficient mice.
Soliman M, Kaplan E, Straus F, Fisfalen ME, Hidaka Y, Guimaraes V, DeGroot LJ
J Clin Endocrinol Metab. 1995
PubMed ID: 7559863
Tumorigenicity of human T-cell leukemia virus type I-infected cell lines in severe combined immunodeficient mice and characterization of the cells proliferating in vivo.
Imada K, Takaori-Kondo A, Akagi T, Shimotohno K, Sugamura K, Hattori T, Yamabe H, Okuma M, Uchiyama T
Blood. 1995
PubMed ID: 7662981
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product.
Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, Admon A, Lees-Miller SP, Anderson CW, Jackson SP
Cell. 1995
PubMed ID: 7671312
X-ray induced translocations in bone marrow cells of scid and wild type mice detected by fluorescence in situ hybridization using mouse chromosome specific DNA libraries.
Grigorova M, Boei JJ, van Duyn-Goedhart A, Natarajan AT, van Buul PP
Mutat Res. 1995
PubMed ID: 7666867
In vivo sequestration of Plasmodium falciparum-infected human erythrocytes: a severe combined immunodeficiency mouse model for cerebral malaria.
Willimann K, Matile H, Weiss NA, Imhof BA
J Exp Med. 1995
PubMed ID: 7650476
BCL-2 expression by leukaemic blasts in a SCID mouse model of biphenotypic leukaemia associated with the t(4;11)(q21;q23) translocation.
Pocock CF, Malone M, Booth M, Evans M, Morgan G, Greil J, Cotter FE
Br J Haematol. 1995
PubMed ID: 7669664
Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8.
Sipley JD, Menninger JC, Hartley KO, Ward DC, Jackson SP, Anderson CW
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7638222
Regional expression of murine intestinal immune cells in normal and isografted intestine.
Okuyama S, Rubin D, Woodley M, Peters MG
Cell Immunol. 1995
PubMed ID: 7606793
Lol p I-specific IgE and IgG synthesis by peripheral blood mononuclear cells from atopic subjects in SCID mice.
Gagnon R, Boutin Y, Hébert J
J Allergy Clin Immunol. 1995
PubMed ID: 7797796
Development of B cells in scid mice with immunoglobulin transgenes: implications for the control of V(D)J recombination.
Chang Y, Bosma GC, Bosma MJ
Immunity. 1995
PubMed ID: 7796294
Defective killing of Candida albicans hyphae by neutrophils from beige mice.
Jones-Carson J, Vazquez-Torres A, Balish E
J Infect Dis. 1995
PubMed ID: 7769315
Regulation of early T cell development by the engagement of TCR-beta complex expressed on fetal thymocytes from TCR-beta-transgenic scid mice.
Takahama Y, Sugaya K, Tsuda S, Hasegawa T, Hashimoto Y
J Immunol. 1995
PubMed ID: 7751632
A novel SCID mouse model for studying spontaneous metastasis of human lung cancer to human tissue.
Teraoka S, Kyoizumi S, Seyama T, Yamakido M, Akiyama M
Jpn J Cancer Res. 1995
PubMed ID: 7790314
X-ray-induced chromosomal aberrations and cell killing in somatic and germ cells of the scid mouse.
Van Buul PP, De Rooij DG, Zandman IM, Grigorova M, Van Duyn-Goedhart A
Int J Radiat Biol. 1995
PubMed ID: 7775830
Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice.
Rohane PW, Shimada A, Kim DT, Edwards CT, Charlton B, Shultz LD, Fathman CG
Diabetes. 1995
PubMed ID: 7729614
Optimization of in vivo tumor targeting in SCID mice with divalent forms of 741F8 anti-c-erbB-2 single-chain Fv: effects of dose escalation and repeated i.v. administration.
Adams GP, McCartney JE, Wolf EJ, Eisenberg J, Tai MS, Huston JS, Stafford WF, Bookman MA, Houston LL, Weiner LM
Cancer Immunol Immunother. 1995
PubMed ID: 7600561
Lethally irradiated normal strains of mice radioprotected with SCID bone marrow develop sensitivity to low doses of staphylococcal enterotoxin B.
Aboud-Pirak E, Lubin I, Pirak ME, Canaan A, Lowell GH, Reisner Y
Immunol Lett. 1995
PubMed ID: 7590935
Sequence analysis and antigen binding characteristics of Ig SCID Ig+ mice.
Young D, Kearney JF
Int Immunol. 1995
PubMed ID: 7547707
Effector cells must recognize antigens expressed in the graft to cause efficient skin graft rejection in SCID mice.
Wecker H, Grusby MJ, Auchincloss H
Transplantation. 1995
PubMed ID: 7732570
Role of the Entamoeba histolytica cysteine proteinase in amebic liver abscess formation in severe combined immunodeficient mice.
Stanley SL, Zhang T, Rubin D, Li E
Infect Immun. 1995
PubMed ID: 7890426
Pulmonary alveolar proteinosis. A spontaneous and inducible disease in immunodeficient germ-free mice.
Warner T, Balish E
Am J Pathol. 1995
PubMed ID: 7717446
Cell counts in peripheral blood and bone marrow of male C.B-17 scid/scid mice.
Matsumoto K, Inukai S, Isaka T, Aruga N, Nakamura S, Nagasawa T, Naito J
Lab Anim. 1995
PubMed ID: 7603011
Tumor dormancy and cell signaling. II. Antibody as an agonist in inducing dormancy of a B cell lymphoma in SCID mice.
Racila E, Scheuermann RH, Picker LJ, Yefenof E, Tucker T, Chang W, Marches R, Street NE, Vitetta ES, Uhr JW
J Exp Med. 1995
PubMed ID: 7535341
Retroviral Producer Cells Cause Sarcoma in Severe Combined Immunodeficiency Mice.
Tung FY, Kelly VS, Hendricks JB
J Biomed Sci. 1995
PubMed ID: 11725048
Stimulation of defective DNA transfer activity in recombination deficient SCID cell extracts by a 72-kDa protein from wild-type thymocytes.
Jessberger R, Riwar B, Rolink A, Rodewald HR
J Biol Chem. 1995
PubMed ID: 7896825
Analysis of the intra-epithelial lymphocyte compartment in SCID mice that received co-isogenic CD4+ T cells. Evidence that mature post-thymic CD4+ T cells can be induced to express CD8 alpha in vivo.
Morrissey PJ, Charrier K, Horovitz DA, Fletcher FA, Watson JD
J Immunol. 1995
PubMed ID: 7876540
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.
Blunt T, Finnie NJ, Taccioli GE, Smith GC, Demengeot J, Gottlieb TM, Mizuta R, Varghese AJ, Alt FW, Jeggo PA
Cell. 1995
PubMed ID: 7889575
Encephalitogenic T lymphocytes develop from SJL/J hematopoietic cells transplanted into severe combined immunodeficient (SCID) mice.
Jones RE, Whitham RH, Sullivan T, Mass M, Bourdette DN
J Neuroimmunol. 1995
PubMed ID: 7535789
Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma.
Chambers R, Gillespie GY, Soroceanu L, Andreansky S, Chatterjee S, Chou J, Roizman B, Whitley RJ
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7877992
DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect.
Kirchgessner CU, Patil CK, Evans JW, Cuomo CA, Fried LM, Carter T, Oettinger MA, Brown JM
Science. 1995
PubMed ID: 7855601
Thermal response and hyperthermic radiosensitization of scid mouse bone marrow CFU-C.
O'Hara MD, Pollard MD, Wheatley G, Regine WF, Mohiuddin M, Leeper DB
Int J Radiat Oncol Biol Phys. 1995
PubMed ID: 7860404
The SCID mouse as a model for multiple myeloma.
Ahsmann EJ, van Tol MJ, Oudeman-Gruber J, Lokhorst H, Uytdehaag FG, Schuurman HJ, Bloem AC
Br J Haematol. 1995
PubMed ID: 7873382
The usefulness of severe combined immunodeficiency (SCID) mice to study human carcinogenesis.
Ito T, Seyama T, Kyoizumi S, Teraoka S, Iwamoto KS, Mizuno T, Tsuyama N, Asahara T, Dohi K, Akiyama M
Cancer Lett. 1995
PubMed ID: 7850767
Interactions of the scid or beige mutations with the viable motheaten mutation.
Dominique V, Francis L
Autoimmunity. 1995
PubMed ID: 8781712
Genetic mapping of reovirus virulence and organ tropism in severe combined immunodeficient mice: organ-specific virulence genes.
Haller BL, Barkon ML, Vogler GP, Virgin HW
J Virol. 1995
PubMed ID: 7983730
Differential Epstein-Barr virus gene expression in B-cell subsets recovered from lymphomas in SCID mice after transplantation of human peripheral blood lymphocytes.
Rochford R, Mosier DE
J Virol. 1995
PubMed ID: 7983705
Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination.
Zhu C, Roth DB
Immunity. 1995
PubMed ID: 7600297
Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet.
Fyfe AI, Qiao JH, Lusis AJ
J Clin Invest. 1994
PubMed ID: 7989611
Differential radiosensitising effect of the scid mutation among tissues, studied using high and low dose rates: implications for prognostic indicators in radiotherapy.
Hendry JH, Jiang TN
Radiother Oncol. 1994
PubMed ID: 7716261
Adenovirus E3 14.7-kilodalton protein, an antagonist of tumor necrosis factor cytolysis, increases the virulence of vaccinia virus in severe combined immunodeficient mice.
Tufariello JM, Cho S, Horwitz MS
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7971996
Human villous adenomas engrafted into scid mice survive for prolonged period without malignant transformation.
Bumpers HL, Alosco TR, Wang HQ, Petrelli NJ, Hoover EL, Bankert RB
J Clin Invest. 1994
PubMed ID: 7962563
Transfer of Sjögren's syndrome-like autoimmune lesions into SCID mice and prevention of lesions by anti-CD4 and anti-T cell receptor antibody treatment.
Hayashi Y, Haneji N, Hamano H, Yanagi K
Eur J Immunol. 1994
PubMed ID: 7957574
Complementation of V(D)J recombination defect and X-ray sensitivity of scid mouse cells by human chromosome 8.
Banga SS, Hall KT, Sandhu AK, Weaver DT, Athwal RS
Mutat Res. 1994
PubMed ID: 7526201
Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model.
Cotter FE, Johnson P, Hall P, Pocock C, al Mahdi N, Cowell JK, Morgan G
Oncogene. 1994
PubMed ID: 8084613
Enhancement of pancreatic tumor metastasis in transgenic immunodeficient mice.
Gallo-Hendrikx E, Copps J, Percy D, Croy BA, Wildeman AG
Oncogene. 1994
PubMed ID: 8084602
Myogenesis in thymic transplants in the severe combined immunodeficient mouse model of myasthenia gravis. Differentiation of thymic myoid cells into striated muscle cells.
Spuler S, Marx A, Kirchner T, Hohlfeld R, Wekerle H
Am J Pathol. 1994
PubMed ID: 7943168
Targeting of pancreatic islets of severe combined immunodeficient mice by passive transfer of allogeneic spleen cells from non-obese diabetic mice.
Reddy S, Liu W, Elliott RB
Immunol Cell Biol. 1994
PubMed ID: 7835983
Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells.
Powrie F, Leach MW, Mauze S, Menon S, Caddle LB, Coffman RL
Immunity. 1994
PubMed ID: 7600284
Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts.
Alegre ML, Peterson LJ, Jeyarajah DR, Weiser M, Bluestone JA, Thistlethwaite JR
J Immunol. 1994
PubMed ID: 8077678
Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse.
Murray AG, Petzelbauer P, Hughes CC, Costa J, Askenase P, Pober JS
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8090783
Long-term lymphoid reconstitution of SCID mice suggests self-renewing B and T cell populations in peripheral and mucosal tissues.
Hilbert DM, Anderson AO, Holmes KL, Rudikoff S
Transplantation. 1994
PubMed ID: 8073516
Homing and antigenic characterization of a human non-Hodgkin's lymphoma B cell line in severe combined immunodeficient (SCID) mice.
de Kroon JF, Kluin PM, Kluin-Nelemans HC, Willemze R, Falkenburg JH
Leukemia. 1994
PubMed ID: 8057678
VH11 bias and normal V-D-J junctions in SCID B lymphocytes rescued by neonatal T cell transfer.
Riggs JE, Feeney AJ, Kirven M, Mosier DE
Mol Immunol. 1994
PubMed ID: 8047070
Split tolerance between spleen and lymph node cells in severe combined immunodeficiency mice grafted with AKR fetal liver cells.
Maeda K, Nagasawa H, Furukawa A, Hisaeda H, Himeno K
Int Immunol. 1994
PubMed ID: 7981149
Follicular development from ovarian xenografts in SCID mice.
Gosden RG, Boulton MI, Grant K, Webb R
J Reprod Fertil. 1994
PubMed ID: 7966017
Low-dose interleukin 2 prevents the development of Epstein-Barr virus (EBV)-associated lymphoproliferative disease in scid/scid mice reconstituted i.p. with EBV-seropositive human peripheral blood lymphocytes.
Baiocchi RA, Caligiuri MA
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7911241
scid cells efficiently integrate hairpin and linear DNA substrates.
Staunton JE, Weaver DT
Mol Cell Biol. 1994
PubMed ID: 8196630
Analysis of the human anti-pig cellular immune response using the Hu-scid mouse-porcine skin graft model.
Moss A, Fryer JP, Leventhal JR, Simone P, Chen S, Reinsmoen N, Matas AJ
Transplant Proc. 1994
PubMed ID: 8029889
Attenuation of lpr-graft-versus-host disease (GVHD) in MRL/lpr spleen cell-injected SCID mice by in vivo treatment with anti-V beta 8.1,2 monoclonal antibody.
Hosaka N, Nagata N, Miyashima S, Ikehara S
Clin Exp Immunol. 1994
PubMed ID: 8004820
Effect of total body irradiation, busulfan-cyclophosphamide, or cyclophosphamide conditioning on inflammatory cytokine release and development of acute and chronic graft-versus-host disease in H-2-incompatible transplanted SCID mice.
Xun CQ, Thompson JS, Jennings CD, Brown SA, Widmer MB
Blood. 1994
PubMed ID: 8161803
Murine granulated metrial gland cell population in beige (bg/bg) and SCID (scid/scid) genotypes.
Yoshizawa M, Okada T, Morikawa Y, Sasaki F, Kiso Y
J Vet Med Sci. 1994
PubMed ID: 8075241
Bcl-2 expression promotes B- but not T-lymphoid development in scid mice.
Strasser A, Harris AW, Corcoran LM, Cory S
Nature. 1994
PubMed ID: 8133891
Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes.
Gerling IC, Friedman H, Greiner DL, Shultz LD, Leiter EH
Diabetes. 1994
PubMed ID: 8314017
Acute, lethal, natural killer cell-resistant myeloproliferative disease induced by polyomavirus in severe combined immunodeficient mice.
Szomolanyi-Tsuda E, Dundon PL, Joris I, Shultz LD, Woda BA, Welsh RM
Am J Pathol. 1994
PubMed ID: 8311119
The use of severe combined immunodeficiency mice to study the metabolism of human immunoglobulin G.
Zuckier LS, Georgescu L, Chang CJ, Scharff MD, Morrison SL
Cancer. 1994
PubMed ID: 8306262
The functional state of follicular dendritic cells in severe combined immunodeficient (SCID) mice: role of the lymphocytes.
Yoshida K, van den Berg TK, Dijkstra CD
Eur J Immunol. 1994
PubMed ID: 8299696
Protective reconstitution of the SCID mouse against reactivation of toxoplasmic encephalitis.
Beaman MH, Araujo FG, Remington JS
J Infect Dis. 1994
PubMed ID: 8106771
Hematopoietic cytokines enhance survival of SCID mice undergoing high-dose irradiation.
Wu DD, Bosch B, Keating A
Exp Hematol. 1994
PubMed ID: 7507860
A human gene that restores the DNA-repair defect in SCID mice is located on 8p11.1-->q11.1.
Kurimasa A, Nagata Y, Shimizu M, Emi M, Nakamura Y, Oshimura M
Hum Genet. 1994
PubMed ID: 8270250
Signs and lesions of experimental Sendai virus infection in two genetically distinct strains of SCID/beige mice.
Percy DH, Auger DC, Croy BA
Vet Pathol. 1994
PubMed ID: 8140728
Graves' disease thyroid tissue transplants in scid mice: persistent selectivity in hTcR Va gene family use.
De Riu S, Martin A, Valentine M, Concepcion ES, Shultz LD, Davies TF
Autoimmunity. 1994
PubMed ID: 7578854
Disseminated growth of Hodgkin's-derived cell lines L540 and L540cy in immune-deficient SCID mice.
Kapp U, Düx A, Schell-Frederick E, Banik N, Hummel M, Mücke S, Fonatsch C, Bullerdiek J, Gottstein C, Engert A
Ann Oncol. 1994
PubMed ID: 7513537
Complementation of the radiosensitive phenotype in severe combined immunodeficient mice by human chromosome 8.
Kirchgessner CU, Tosto LM, Biedermann KA, Kovacs M, Araujo D, Stanbridge EJ, Brown JM
Cancer Res. 1993
PubMed ID: 8261415
Engraftment of human synovium into severe combined immune deficient mice. Migration of human peripheral blood T cells to engrafted human synovium and to mouse lymph nodes.
Rendt KE, Barry TS, Jones DM, Richter CB, McCachren SS, Haynes BF
J Immunol. 1993
PubMed ID: 8258726
The SCID mouse: relevance as an animal model system for studying human disease.
Hendrickson EA
Am J Pathol. 1993
PubMed ID: 8256843
V(D)J recombination in peritoneal B cells of leaky scid mice.
Kotloff DB, Bosma MJ, Ruetsch NR
J Exp Med. 1993
PubMed ID: 8245777
New animal models for human autoimmune thyroid disease. Xenografts of human thyroid tissue in severe combined immunodeficient (SCID) and nude mice.
Volpé R, Akasu F, Morita T, Yoshikawa N, Resetkova E, Arreaza G, Mukuta T
Horm Metab Res. 1993
PubMed ID: 8119666
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for the treatment of lethal vaccinia virus infections in severe combined immune deficiency (SCID) mice.
Neyts J, De Clercq E
J Med Virol. 1993
PubMed ID: 8263505
Propagation of human papillomavirus type 11 in human xenografts using the severe combined immunodeficiency (SCID) mouse and comparison to the nude mouse model.
Bonnez W, Rose RC, Da Rin C, Borkhuis C, de Mesy Jensen KL, Reichman RC
Virology. 1993
PubMed ID: 8212584
Chlamydia trachomatis pneumonia in the severe combined immunodeficiency (SCID) mouse.
Magee DM, Igietseme JU, Smith JG, Bleicker CA, Grubbs BG, Schachter J, Rank RG, Williams DM
Reg Immunol. 1993
PubMed ID: 7520728
SCID mice as models for parasitic infections.
Stanley SL, Virgin HW
Parasitol Today. 1993
PubMed ID: 15463679
Quantitative comparison between the transplantability of human and murine tumors into the brain of NCr/Sed-nu/nu nude and severe combined immunodeficient mice.
Taghian A, Budach W, Zietman A, Freeman J, Gioioso D, Suit HD
Cancer Res. 1993
PubMed ID: 8402693
The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites.
Liu SH, Ma JT, Yueh AY, Lees-Miller SP, Anderson CW, Ng SY
J Biol Chem. 1993
PubMed ID: 8407951
Functional and phenotypic analysis of thymocytes in SCID mice. Evidence for functional response transitions before and after the SCID arrest point.
Rothenberg EV, Chen D, Diamond RA
J Immunol. 1993
PubMed ID: 8376791
Branhamella catarrhalis pathogenesis in SCID and SCID/beige mice. Brief report.
Harkness RE, Guimond MJ, McBey BA, Klein MH, Percy DH, Croy BA
APMIS. 1993
PubMed ID: 8267959
The induction of CD10 on a pre-B leukemia cell line occurs with progression of the disease in scid mice.
Ishii E, Greaves A, Grunberger T, Freedman MH, Letarte M
Leukemia. 1993
PubMed ID: 7692193
A model of human immunodeficiency virus encephalitis in scid mice.
Tyor WR, Power C, Gendelman HE, Markham RB
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8378344
The SCID mouse as a laboratory model for development of the exoerythrocytic stages of human and rodent malaria.
Butcher GA, Couchman AF, Van Pelt JF, Fleck SL, Sinden RE
Exp Parasitol. 1993
PubMed ID: 8375494
High frequency of normal DJH joints in B cell progenitors in severe combined immunodeficiency mice.
Pennycook JL, Chang Y, Celler J, Phillips RA, Wu GE
J Exp Med. 1993
PubMed ID: 8350042
Granulosa cell tumorigenesis in genetically hypogonadal-immunodeficient mice grafted with ovaries from tumor-susceptible donors.
Beamer WG, Shultz KL, Tennent BJ, Shultz LD
Cancer Res. 1993
PubMed ID: 8339285
The scid mutation in mice causes defects in the repair system for both double-strand DNA breaks and DNA cross-links.
Tanaka T, Yamagami T, Oka Y, Nomura T, Sugiyama H
Mutat Res. 1993
PubMed ID: 7688088
Functional complementation in mouse-human radiation hybrids assigns the putative murine scid gene to the pericentric region of human chromosome 8.
Komatsu K, Ohta T, Jinno Y, Niikawa N, Okumura Y
Hum Mol Genet. 1993
PubMed ID: 8364539
The severe combined immunodeficient (SCID) mouse as a model for the study of autoimmune diseases.
Vladutiu AO
Clin Exp Immunol. 1993
PubMed ID: 8324894
The SCID-hu mouse as a model for HIV-1 infection.
Aldrovandi GM, Feuer G, Gao L, Jamieson B, Kristeva M, Chen IS, Zack JA
Nature. 1993
PubMed ID: 8515816
The SCID-ra mouse: rat T-cell differentiation in the severe combined immunodeficient mouse.
De Heer C, Verlaan AP, Penninks AH, Schuurman HJ, Van Loveren H
APMIS. 1993
PubMed ID: 8103346
The mouse severe combined immune deficiency (scid) mutation is closely linked to the B-cell-specific developmental genes VpreB and lambda 5.
Miller RD, Ozaki JH, Riblet R
Genomics. 1993
PubMed ID: 8100803
Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.
Zheng CF, Guan KL
J Biol Chem. 1993
PubMed ID: 8388392
Bacterial superantigens mediate T cell deletions in the mouse severe combined immunodeficiency-human liver/thymus model.
Baccala R, Vandekerckhove BA, Jones D, Kono DH, Roncarolo MG, Theofilopoulos AN
J Exp Med. 1993
PubMed ID: 8478618
Strain-dependent leakiness of mice with severe combined immune deficiency.
Nonoyama S, Smith FO, Bernstein ID, Ochs HD
J Immunol. 1993
PubMed ID: 8473734
Activated natural killer cells suppress myelopoiesis in mice with severe combined immunodeficiency.
Pisa P, Sitnicka E, Hansson M
Scand J Immunol. 1993
PubMed ID: 8469936
Lethal exacerbation of Pneumocystis carinii pneumonia in severe combined immunodeficiency mice after infection by pneumonia virus of mice.
Roths JB, Smith AL, Sidman CL
J Exp Med. 1993
PubMed ID: 8459214
Studies of virus-induced myocardial injury in mice: value of the scid mutation on different genetic backgrounds and combined with other mutations.
Chow LH
Lab Anim Sci. 1993
PubMed ID: 8391609
The study of human neoplastic disease in severe combined immunodeficient mice.
Williams SS, Alosco TR, Croy BA, Bankert RB
Lab Anim Sci. 1993
PubMed ID: 8320961
Spontaneous and experimental infections in scid and scid/beige mice.
Percy DH, Barta JR
Lab Anim Sci. 1993
PubMed ID: 8320959
What are scid mice and why is it timely to devote a special topic issue to them?
Croy BA, Percy DH, Smith AL
Lab Anim Sci. 1993
PubMed ID: 8320956
Comparative abilities of athymic nude mice and severe combined immune deficient (SCID) mice to accept transplants of induced rat mammary carcinomas: enhanced transplantation efficiency of those rat mammary carcinomas that have elevated expression of neu o
Oakley CS, Welsch MA, Zhai YF, Chang CC, Gould MN, Welsch CW
Int J Cancer. 1993
PubMed ID: 8097186
Characterization of the DNA double strand break repair defect in scid mice.
Chang C, Biedermann KA, Mezzina M, Brown JM
Cancer Res. 1993
PubMed ID: 8443804
c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif.
Bannister AJ, Gottlieb TM, Kouzarides T, Jackson SP
Nucleic Acids Res. 1993
PubMed ID: 8464713
Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCR beta transgene.
Shores EW, Nakayama T, Wiest DL, Takahama Y, Sharrow S, Singer A
J Immunol. 1993
PubMed ID: 8094405
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen.
Gottlieb TM, Jackson SP
Cell. 1993
PubMed ID: 8422676
Reduction of leaky lymphocyte clones producing immunoglobulins and thymic lymphocytic leukemia by selective inbreeding of SCID (severe combined immunodeficiency) mice.
Inohara H, Nomura T, Hongyo T, Nakajima H, Kawaguchi T, Fukuda K, Sutoh K, Iwasa T, Matsunaga T
Acta Otolaryngol Suppl. 1993
PubMed ID: 8447219
Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation.
Mosier DE, Stell KL, Gulizia RJ, Torbett BE, Gilmore GL
J Exp Med. 1993
PubMed ID: 8418200
Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen.
Mamalaki C, Elliott J, Norton T, Yannoutsos N, Townsend AR, Chandler P, Simpson E, Kioussis D
Dev Immunol. 1993
PubMed ID: 8281031
A severe combined immunodeficient (SCID) mouse model for infection with Entamoeba histolytica.
Cieslak PR, Virgin HW, Stanley SL
J Exp Med. 1992
PubMed ID: 1460420
Herpes simplex virus type 1 mutant strain in1814 establishes a unique, slowly progressing infection in SCID mice.
Valyi-Nagy T, Deshmane SL, Raengsakulrach B, Nicosia M, Gesser RM, Wysocka M, Dillner A, Fraser NW
J Virol. 1992
PubMed ID: 1331523
Analysis of the defect in DNA end joining in the murine scid mutation.
Harrington J, Hsieh CL, Gerton J, Bosma G, Lieber MR
Mol Cell Biol. 1992
PubMed ID: 1406659
CD3+ T cells in severe combined immunodeficiency (scid) mice. VI. Rescue of scid-derived, IgM-producing B cells by transfer of CD4+ CD8- T cells from various lymphoid organs.
Rudolphi A, Claesson MH, Reimann J
Immunology. 1992
PubMed ID: 1358814
Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency (scid) mutation or X-linked immunodeficiency (xid) defect.
Roberts JL, Abe R, Shores EW, Singer A
J Immunol. 1992
PubMed ID: 1506683
Immune responses to Cryptosporidium muris and Cryptosporidium parvum in adult immunocompetent or immunocompromised (nude and SCID) mice.
McDonald V, Deer R, Uni S, Iseki M, Bancroft GJ
Infect Immun. 1992
PubMed ID: 1639500
Comparison of susceptibility of inbred and outbred infant mice to Escherichia coli heat-stable enterotoxin STa.
Bertin A
Infect Immun. 1992
PubMed ID: 1639480
Unexpected effects of the severe combined immunodeficiency mutation on murine lymphomagenesis.
Lieberman M, Hansteen GA, Waller EK, Weissman IL, Sen-Majumdar A
J Exp Med. 1992
PubMed ID: 1500852
DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein.
Iijima S, Teraoka H, Date T, Tsukada K
Eur J Biochem. 1992
PubMed ID: 1597196
Hemagglutination and graft-versus-host disease in the severe combined immunodeficiency mouse lymphoproliferative disease model.
Pirruccello SJ, Nakamine H, Beisel KW, Kleveland KL, Okano M, Taguchi Y, Davis JR, Mahloch ML, Purtilo DT
Am J Pathol. 1992
PubMed ID: 1580330
The severe combined immunodeficient (SCID) mouse as a model for human myeloid leukemias.
Cesano A, Hoxie JA, Lange B, Nowell PC, Bishop J, Santoli D
Oncogene. 1992
PubMed ID: 1570153
Current status review: the severe combined immunodeficient (SCID) mouse: xenogeneic-SCID chimeras in the investigation of human autoimmune disease.
Taylor PC
Int J Exp Pathol. 1992
PubMed ID: 1571284
Dynamics and localization of early B-lymphocyte precursor cells (pro-B cells) in the bone marrow of scid mice.
Osmond DG, Kim N, Manoukian R, Phillips RA, Rico-Vargas SA, Jacobsen K
Blood. 1992
PubMed ID: 1373084
Interleukin 1 participates in the development of anti-Listeria responses in normal and SCID mice.
Rogers HW, Sheehan KC, Brunt LM, Dower SK, Unanue ER, Schreiber RD
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1531270
Defective repair of radiation-induced chromosomal damage in scid/scid mice.
Disney JE, Barth AL, Shultz LD
Cytogenet Cell Genet. 1992
PubMed ID: 1733671
T cell receptor gamma and delta gene rearrangements in scid thymocytes. Similarity to those in normal thymocytes.
Kienker LJ, Kuziel WA, Garni-Wagner BA, Kumar V, Tucker PW
J Immunol. 1991
PubMed ID: 1661315
The scid mouse: mutation in a DNA repair gene creates recipients useful for studies on stem cells, lymphocyte development and graft-versus-host disease.
Phillips RA, Spaner DE
Immunol Rev. 1991
PubMed ID: 1804782
Skeletal muscle rhabdomyosarcomas in inbred laboratory mice.
Sundberg JP, Adkison DL, Bedigian HG
Vet Pathol. 1991
PubMed ID: 1830433
scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.
Biedermann KA, Sun JR, Giaccia AJ, Tosto LM, Brown JM
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1996340
The SCID mouse.
Pla M, Mahouy G
Nouv Rev Fr Hematol. 1991
PubMed ID: 1818304
A DNA-activated protein kinase from HeLa cell nuclei.
Carter T, Vancurová I, Sun I, Lou W, DeLeon S
Mol Cell Biol. 1990
PubMed ID: 2247066
The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues.
Lees-Miller SP, Anderson CW
J Biol Chem. 1989
PubMed ID: 2507541
The mouse mutation severe combined immune deficiency (scid) is on chromosome 16.
Bosma GC, Davisson MT, Ruetsch NR, Sweet HO, Shultz LD, Bosma MJ
Immunogenetics. 1989
PubMed ID: 2908877
The scid mouse mutant.
Bosma M, Schuler W, Bosma G
Curr Top Microbiol Immunol. 1988
PubMed ID: 3416632
Genetically determined murine models of immunodeficiency.
Shultz LD, Sidman CL
Annu Rev Immunol. 1987
PubMed ID: 3297105
Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency.
Schuler W, Weiler IJ, Schuler A, Phillips RA, Rosenberg N, Mak TW, Kearney JF, Perry RP, Bosma MJ
Cell. 1986
PubMed ID: 3093081
Full reconstitution of the immune deficiency in scid mice with normal stem cells requires low-dose irradiation of the recipients.
Fulop GM, Phillips RA
J Immunol. 1986
PubMed ID: 3519770
Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms.
Custer RP, Bosma GC, Bosma MJ
Am J Pathol. 1985
PubMed ID: 2412448
Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease.
Dorshkind K, Keller GM, Phillips RA, Miller RG, Bosma GC, O'Toole M, Bosma MJ
J Immunol. 1984
PubMed ID: 6607948
A severe combined immunodeficiency mutation in the mouse.
Bosma GC, Custer RP, Bosma MJ
Nature. 1983
PubMed ID: 6823332
The natural history and immunopathology of outbred athymic (nude) mice.
Gershwin ME, Merchant B, Gelfand MC, Vickers J, Steinberg AD, Hansen CT
Clin Immunol Immunopathol. 1975
PubMed ID: 1104226
Polymorphism of histocompatibility genes in the mouse.
Graff RJ
Transplant Proc. 1970
PubMed ID: 4107291

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	Human	Mouse	Rat
Entrez Gene	5591	19090	360748
EnsEMBL Gene(s)	ENSG00000253729 LRG_162	ENSMUSG00000022672	N/A
Unigene	Hs.491682	Mm.71	N/A
Homologene	PRKDC	Prkdc	Prkdc
OMIM	600899	N/A	N/A
GeneCards	PRKDC	N/A	N/A
Beta Cell Genomics	DT.100798105 DT.100798110 DT.447515 DT.91810315	DT.101703004 DT.488196 DT.91414116	N/A
Reactome	P78527	N/A	N/A
Plasma Peptide Atlas	ENSP00000313420	N/A	N/A
WikiGenes	5591	19090	360748

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Interactor	Interactor	Sources	Classification	Pubmed IDs
PRKDC	HDAC5	BioGRID	empirical	21081666
PRKDC	SAP25	IntAct, BioGRID	empirical	16449650
PRKDC	CHAF1A	BioGRID	empirical	21209461
PRKDC	C1D	HPRD	empirical	9679063
PRKDC	CIB1	HPRD, BioGRID	empirical	9372844 15190070
PRKDC	KAT5	BioGRID	empirical	16603769
PRKDC	CAMKK2	IntAct, BioGRID	empirical	20562859
PRKDC	CFTR	IntAct	empirical	17110338
PRKDC	MSL3	BioGRID	empirical	20479123
PRKDC	YWHAQ	BioGRID	empirical	20618440 15161933
PRKDC	RIPK3	MINT, IntAct	empirical	14743216
PRKDC	CHEK1	BioGRID	empirical	10608806 12756247
PRKDC	CBX3	IntAct	empirical	21888893
PRKDC	GABARAP	IntAct	empirical	20562859
PRKDC	GABARAPL2	IntAct	empirical	20562859
PRKDC	CHUK	HPRD, BioGRID	empirical	9632806
PRKDC	CLN3	IntAct, BioGRID	empirical	20562859
PRKDC	PARP1	HPRD, IntAct, BioGRID	empirical	9398855 20085707 21575865 16794079
PRKDC	CSNK2A2	IntAct	empirical	20711232
PRKDC	SGOL1	HPRD	empirical	16541024
PRKDC	AP1B1	BioGRID	empirical	10608806
PRKDC	DHX9	BioGRID	empirical	15613478
PRKDC	E4F1	BioGRID	empirical	10608806
PRKDC	AKT1	HPRD	empirical	15262962
PRKDC	ERG	IntAct	empirical	21575865
PRKDC	AKT2	BioGRID	empirical	16221682
PRKDC	ESR1	IntAct, BioGRID	empirical	21182205 16794079
PRKDC	ESR2	IntAct	empirical	21182203
PRKDC	ETS1	IntAct	empirical	21575865
PRKDC	ETV1	IntAct	empirical	21575865
PRKDC	PPP6R1	BioGRID	empirical	20065038
PRKDC	NCOA6	HPRD, BioGRID	empirical	12519782 10823961
PRKDC	GABARAPL1	IntAct	empirical	20562859
PRKDC	ABL1	HPRD, BioGRID	empirical	9312071
PRKDC	XRCC6	HPRD, IntAct, BioGRID	empirical	11279128 10446239 9312071 17308091 19303849 20711232 21575865 10064605 15520013 8422676
PRKDC	NPHP4	IntAct	empirical	21565611
PRKDC	GBAS	IntAct, BioGRID	empirical	20562859
PRKDC	KAT2A	BioGRID	empirical	9488450
PRKDC	GRB2	IntAct	empirical	12577067
PRKDC	NR3C1	HPRD	empirical	9038175
PRKDC	TFCP2L1	BioGRID	empirical	20362541
PRKDC	GZMB	HPRD	empirical	9586635
PRKDC	HIST1H1C	BioGRID	empirical	18258596
PRKDC	H2AFX	IntAct, BioGRID	empirical	20085707 14627815 15613478 18406329 20356835
PRKDC	HIST1H1A	BioGRID	empirical	20356835
PRKDC	HDGF	IntAct	empirical	21907836
PRKDC	HDLBP	BioGRID	empirical	15723802
PRKDC	HMGB1	HPRD	empirical	9722660
PRKDC	HMGB2	HPRD	empirical	9722660
PRKDC	HOXB7	IntAct, BioGRID	empirical	17308091
PRKDC	HOXC4	HPRD	empirical	11279128
PRKDC	AIRE	IntAct, BioGRID	empirical	20085707
PRKDC	HSF1	HPRD, BioGRID	empirical	9325337
PRKDC	BIRC5	BioGRID	empirical	20394854
PRKDC	HSP90AA1	HPRD	empirical	2507541
PRKDC	HSP90AB1	MINT, IntAct	empirical	16263121
PRKDC	IKBKB	BioGRID	empirical	9632806
PRKDC	ILF2	HPRD, BioGRID	empirical	9442054 17389650
PRKDC	PDX1	BioGRID	empirical	16166097
PRKDC	JUN	HPRD	empirical	8464713
PRKDC	LIG4	HPRD, BioGRID, Reactome	empirical	15194694 10608806 9430729 9259561
PRKDC	LYN	HPRD, BioGRID	empirical	9748231
PRKDC	MAP3K3	MINT, IntAct	empirical	14743216
PRKDC	MGMT	BioGRID	empirical	16226712
PRKDC	MLH1	BioGRID	empirical	17148452
PRKDC	MRE11A	BioGRID	empirical	19015239
PRKDC	MYC	IntAct, BioGRID	empirical	17314511
PRKDC	NBN	HPRD, BioGRID	empirical	15758953
PRKDC	NCF2	BioGRID	empirical	9914162
PRKDC	NCF4	BioGRID	empirical	9914162
PRKDC	ATM	HPRD	empirical	10464290
PRKDC	NFKB1	MINT	empirical	14743216
PRKDC	NFKB2	MINT, IntAct	empirical	14743216
PRKDC	NFKBIE	IntAct	empirical	14743216
PRKDC	PCNA	HPRD, BioGRID	empirical	12171929
PRKDC	C8orf55	BioGRID	empirical	20360068
PRKDC	SIRT6	BioGRID	empirical	20157594
PRKDC	POU2F1	BioGRID	empirical	17213819 14612514
PRKDC	PPP2CA	BioGRID	empirical	20065038
PRKDC	PPP6R3	BioGRID	empirical	20065038
PRKDC	PIDD	IntAct, BioGRID	empirical	19203584 21415862
PRKDC	PPP6C	BioGRID	empirical	20065038
PRKDC	PRKAB2	IntAct, BioGRID	empirical	20562859
PRKDC	PRKCD	HPRD	empirical	9774685
PRKDC	PRKDC	HPRD, BioGRID	empirical	10823961 12186630 20065038
PRKDC	MAPK8	HPRD, BioGRID	empirical	11749722
PRKDC	MAPK9	BioGRID	empirical	11749722
PRKDC	SMARCAD1	BioGRID	empirical	21549307
PRKDC	AICDA	BioGRID	empirical	15634916
PRKDC	PTS	BioGRID	empirical	10608806
PRKDC	RAD17	BioGRID	empirical	10608806
PRKDC	RBBP8	BioGRID	empirical	10608806
PRKDC	RELA	MINT, IntAct	empirical	14743216
PRKDC	RELB	MINT, IntAct	empirical	14743216
PRKDC	C12orf44	IntAct, BioGRID	empirical	20562859
PRKDC	RPA1	HPRD, BioGRID	empirical	10064605
PRKDC	RPA2	HPRD, BioGRID	empirical	11731442 10064605 9295339
PRKDC	RYK	BioGRID	empirical	21875946
PRKDC	DCLRE1C	HPRD, BioGRID	empirical	11955432 15936993
PRKDC	BMI1	BioGRID	empirical	20668194
PRKDC	NCF1	BioGRID	empirical	9914162
PRKDC	SP1	HPRD, BioGRID	empirical	8422676
PRKDC	SPI1	IntAct	empirical	21575865
PRKDC	BRCA1	BioGRID	empirical	10608806
PRKDC	SRF	HPRD	empirical	8407951
PRKDC	THRA	BioGRID	empirical	17242407
PRKDC	THRB	BioGRID	empirical	17242407
PRKDC	TNFRSF1A	MINT, IntAct	empirical	14743216
PRKDC	TNFRSF1B	MINT, IntAct	empirical	14743216
PRKDC	TOP1	IntAct	empirical	15848144
PRKDC	TOP2A	IntAct	empirical	20085707
PRKDC	TP53	HPRD, BioGRID	empirical	10470151 9765199 11551930 11709713 10673501 10747897 11883897 10951572 10608806 12756247 9679063 15792956
PRKDC	UBC	BioGRID	empirical	16335966 16196087 18781797 21987572 21963094 21139048 21890473 21906983
PRKDC	USF1	HPRD, IntAct, BioGRID	empirical	19303849
PRKDC	WRN	HPRD, BioGRID	empirical	11889123 10608806
PRKDC	XPA	HPRD	empirical	16540648
PRKDC	XRCC4	HPRD, BioGRID, Reactome	empirical	9430729 15520013 9259561
PRKDC	XRCC5	HPRD, IntAct, BioGRID, Reactome	empirical	10207052 10446239 9312071 17308091 19303849 20085707 20711232 12393188 15520013 15758953 9430729 9259561
PRKDC	YY1	IntAct, BioGRID	empirical	18026119
PRKDC	YWHAB	MINT	empirical	15324660
PRKDC	YWHAG	HPRD, MINT	empirical	15324660
PRKDC	YWHAZ	MINT	empirical	15161933
PRKDC	ZIC2	MINT	empirical	18097573
PRKDC	DDA1	IntAct, BioGRID	empirical	20562859
PRKDC	TTI2	IntAct, BioGRID	empirical	20801936
PRKDC	MAP1LC3B	IntAct	empirical	20562859
PRKDC	CASP2	IntAct	empirical	19203584
PRKDC	HIST1H3E	BioGRID	empirical	20504901
PRKDC	CASP3	HPRD	empirical	8804412
PRKDC	ATRIP	HPRD, BioGRID	empirical	15758953
PRKDC	KAT8	BioGRID	empirical	20479123
PRKDC	MAP1LC3A	IntAct	empirical	20562859
PRKDC	ATG4C	IntAct, BioGRID	empirical	20562859
PRKDC	IKBKG	MINT, IntAct	empirical	14743216
PRKDC	MKNK1	IntAct, BioGRID	empirical	20936779
PRKDC	RUVBL1	IntAct	empirical	20371770
PRKDC	BECN1	IntAct, BioGRID	empirical	20562859
PRKDC	TRADD	MINT, IntAct	empirical	14743216
PRKDC	HDAC3	BioGRID	empirical	17242407
PRKDC	EIF2S2	HPRD, BioGRID	empirical	9442054
PRKDC	RECQL5	BioGRID	empirical	19270065
PRKDC	CHD1L	BioGRID	empirical	19666485 19661379
PRKDC	IQCB1	IntAct	empirical	21565611
PRKDC	TTI1	IntAct, BioGRID	empirical	20371770 20810650 20427287
PRKDC	PPP6R2	BioGRID	empirical	20065038
PRKDC	CDC5L	BioGRID	empirical	11101529
PRKDC	TELO2	IntAct	empirical	18160036 20801936
PRKDC	NR1H4	BioGRID	empirical	19833092