PRKCG

Summary Top Help

Gene Description:

protein kinase C, gamma

Synonyms:

Prkcg, Prkc, PKCI, SCA14, PKCgamma, Pkcc, RATPKCI, PKC, PKC-gamma, PKCG, PKCC, PRKCG, Prkcc

Orthologs:

Human PRKCG (protein-coding), Mouse Prkcc (protein-coding), Rat Prkcg (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr19:54382444..54410906 (28.46 kb) View in Genome Browser

(Mouse) NCBIM37 - chr7:3303640..3331005 (27.36 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:64145737..64172745 (271 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PRKCG:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PRKCG:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 30

Biocarta: 1

Reactome: 23

NCI-Nature Pathway Interaction Database: 7

Gene Ontology: 38

Publications from PubMed Top Help

Publications: 330

Conventional protein kinase C-α (PKC-α) and PKC-β negatively regulate RIG-I antiviral signal transduction.
Maharaj NP, Wies E, Stoll A, Gack MU
J Virol. 2012
PubMed ID: 22114345
Spinocerebellar ataxia type 14.
Chen DH, Raskind WH, Bird TD
Handb Clin Neurol. 2012
PubMed ID: 21827914
Specific protein kinase C isoforms are required for rod photoreceptor differentiation.
Pinzon-Guzman C, Zhang SS, Barnstable CJ
J Neurosci. 2011
PubMed ID: 22171059
Mutant PKCγ in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo.
Shuvaev AN, Horiuchi H, Seki T, Goenawan H, Irie T, Iizuka A, Sakai N, Hirai H
J Neurosci. 2011
PubMed ID: 21976518
Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.
Ishiuchi T, Takeichi M
Nat Cell Biol. 2011
PubMed ID: 21685893
Effect of perinatal thyroid hormone deficiency on expression of rat hippocampal conventional protein kinase C isozymes.
Zhang HM, Lin N, Dong Y, Su Q, Luo M
Mol Cell Biochem. 2011
PubMed ID: 21424759
Activation of cytosolic phospholipase A2 downstream of the Src-phospholipase D1 (PLD1)-protein kinase C γ (PKCγ) signaling axis is required for hypoxia-induced pathological retinal angiogenesis.
Zhang Q, Wang D, Singh NK, Kundumani-Sridharan V, Gadiparthi L, Rao ChM, Rao GN
J Biol Chem. 2011
PubMed ID: 21536681
NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor.
Rodríguez-Muñoz M, de la Torre-Madrid E, Sánchez-Blázquez P, Garzón J
Antioxid Redox Signal. 2011
PubMed ID: 21235400
Hypoxic preconditioning induced neuroprotection against cerebral ischemic injuries and its cPKCγ-mediated molecular mechanism.
Zhang N, Yin Y, Han S, Jiang J, Yang W, Bu X, Li J
Neurochem Int. 2011
PubMed ID: 21335048
Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development.
López-Juárez A, Morales-Lázaro S, Sánchez-Sánchez R, Sunkara M, Lomelí H, Velasco I, Morris AJ, Escalante-Alcalde D
Glia. 2011
PubMed ID: 21319224
Cooperative activity of noggin and gremlin 1 in axial skeleton development.
Stafford DA, Brunet LJ, Khokha MK, Economides AN, Harland RM
Development. 2011
PubMed ID: 21303853
PKCγ is required for ethanol-induced increases in GABA(A) receptor α4 subunit expression in cultured cerebral cortical neurons.
Werner DF, Kumar S, Criswell HE, Suryanarayanan A, Fetzer JA, Comerford CE, Morrow AL
J Neurochem. 2011
PubMed ID: 21155805
Changes in the expression of transthyretin and protein kinase Cγ genes in the prefrontal cortex in response to naltrexone.
Yu J, Halder D, Baek MN, Das ND, Choi MR, Oh DY, Choi IG, Jung KH, Chai YG
Neurosci Lett. 2011
PubMed ID: 21111029
Co-localization of neural cell adhesion molecule and fibroblast growth factor receptor 2 in early embryo development.
Vesterlund L, Töhönen V, Hovatta O, Kere J
Int J Dev Biol. 2011
PubMed ID: 21710437
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Age-related increase in PKC gamma expression in the cochlear nucleus of hearing impaired C57BL/6J and BALB/c mice.
Kou ZZ, Zhang Y, Zhang T, Li H, Li YQ
J Chem Neuroanat. 2011
PubMed ID: 21056652
Effect of trehalose on the properties of mutant {gamma}PKC, which causes spinocerebellar ataxia type 14, in neuronal cell lines and cultured Purkinje cells.
Seki T, Abe-Seki N, Kikawada T, Takahashi H, Yamamoto K, Adachi N, Tanaka S, Hide I, Saito N, Sakai N
J Biol Chem. 2010
PubMed ID: 20705605
Congo red, an amyloid-inhibiting compound, alleviates various types of cellular dysfunction triggered by mutant protein kinase cγ that causes spinocerebellar ataxia type 14 (SCA14) by inhibiting oligomerization and aggregation.
Seki T, Takahashi H, Yamamoto K, Ogawa K, Onji T, Adachi N, Tanaka S, Hide I, Saito N, Sakai N
J Pharmacol Sci. 2010
PubMed ID: 20938103
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Spinal mediators that may contribute selectively to antinociceptive tolerance but not other effects of morphine as revealed by deletion of GluR5.
Gregus AM, Inra CN, Giordano TP, Costa AC, Rajadhyaksha AM, Inturrisi CE
Neuroscience. 2010
PubMed ID: 20359526
Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.
Rex EB, Rankin ML, Yang Y, Lu Q, Gerfen CR, Jose PA, Sibley DR
Mol Pharmacol. 2010
PubMed ID: 20395553
Involvement of the spinal NMDA receptor/PKCγ signaling pathway in the development of bone cancer pain.
Xiaoping G, Xiaofang Z, Yaguo Z, Juan Z, Junhua W, Zhengliang M
Brain Res. 2010
PubMed ID: 20362561
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
Martins-de-Souza D, Maccarrone G, Wobrock T, Zerr I, Gormanns P, Reckow S, Falkai P, Schmitt A, Turck CW
J Psychiatr Res. 2010
PubMed ID: 20471030
Mutant protein kinase C gamma that causes spinocerebellar ataxia type 14 (SCA14) is selectively degraded by autophagy.
Yamamoto K, Seki T, Adachi N, Takahashi T, Tanaka S, Hide I, Saito N, Sakai N
Genes Cells. 2010
PubMed ID: 20398063
Protein kinase Cgamma in colon cancer cells: expression, Thr514 phosphorylation and sensitivity to butyrate-mediated upregulation as related to the degree of differentiation.
Garczarczyk D, Szeker K, Galfi P, Csordas A, Hofmann J
Chem Biol Interact. 2010
PubMed ID: 20188713
Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability.
Deng PY, Xiao Z, Jha A, Ramonet D, Matsui T, Leitges M, Shin HS, Porter JE, Geiger JD, Lei S
J Neurosci. 2010
PubMed ID: 20392936
Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice.
Ross SE, Mardinly AR, McCord AE, Zurawski J, Cohen S, Jung C, Hu L, Mok SI, Shah A, Savner EM, Tolias C, Corfas R, Chen S, Inquimbert P, Xu Y, McInnes RR, Rice FL, Corfas G, Ma Q, Woolf CJ, Greenberg ME
Neuron. 2010
PubMed ID: 20346763
[Association study between Protein Kinase C gamma gene polymorphism and major depressive disorder].
Wang X, Sun Y, Sun N, Liu W, Lang XE, Yang R, Wu CS, Zhang KR
Zhonghua Yi Xue Za Zhi. 2010
PubMed ID: 20627017
Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.
Roberts KE, Kawut SM, Krowka MJ, Brown RS, Trotter JF, Shah V, Peter I, Tighiouart H, Mitra N, Handorf E, Knowles JA, Zacks S, Fallon MB, Pulmonary Vascular Complications of Liver Disease Study Group
Gastroenterology. 2010
PubMed ID: 20346360
Protein kinase C: poised to signal.
Newton AC
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 19934406
Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development.
Brzezinski JA, Lamba DA, Reh TA
Development. 2010
PubMed ID: 20110327
Development and validation of a method for profiling post-translational modification activities using protein microarrays.
Del Rincón SV, Rogers J, Widschwendter M, Sun D, Sieburg HB, Spruck C
PLoS One. 2010
PubMed ID: 20596523
Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway.
Ahmed RP, Haider KH, Shujia J, Afzal MR, Ashraf M
PLoS One. 2010
PubMed ID: 20052412
Conventional protein kinase C plays a critical role in negative regulation of CD98-induced homotypic aggregation.
Cho JY, Katz DR, Skubitz KM, Chain BM
Tissue Antigens. 2010
PubMed ID: 19895572
Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance.
Niture SK, Jain AK, Jaiswal AK
J Cell Sci. 2009
PubMed ID: 19920073
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Post-ischaemic activation of kinases in the pre-conditioning-like cardioprotective effect of the platelet-activating factor.
Penna C, Mognetti B, Tullio F, Gattullo D, Mancardi D, Moro F, Pagliaro P, Alloatti G
Acta Physiol (Oxf). 2009
PubMed ID: 19432589
Expression of the mouse PR domain protein Prdm8 in the developing central nervous system.
Komai T, Iwanari H, Mochizuki Y, Hamakubo T, Shinkai Y
Gene Expr Patterns. 2009
PubMed ID: 19616129
Protein kinase C gamma, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin.
Asai H, Hirano M, Shimada K, Kiriyama T, Furiya Y, Ikeda M, Iwamoto T, Mori T, Nishinaka K, Konishi N, Udaka F, Ueno S
Hum Mol Genet. 2009
PubMed ID: 19561170
Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity.
Tao H, Suzuki M, Kiyonari H, Abe T, Sasaoka T, Ueno N
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19706528
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B.
Wouters MM, Roeder JL, Tharayil VS, Stanich JE, Strege PR, Lei S, Bardsley MR, Ordog T, Gibbons SJ, Farrugia G
J Biol Chem. 2009
PubMed ID: 19531484
Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.
Liu Q, Chen X, Macdonnell SM, Kranias EG, Lorenz JN, Leitges M, Houser SR, Molkentin JD
Circ Res. 2009
PubMed ID: 19556521
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Loss of protein kinase Cgamma in knockout mice and increased retinal sensitivity to hyperbaric oxygen.
Yevseyenkov VV, Das S, Lin D, Willard L, Davidson H, Sitaramayya A, Giblin FJ, Dang L, Takemoto DJ
Arch Ophthalmol. 2009
PubMed ID: 19365031
Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome.
Medina CF, Mazerolle C, Wang Y, Bérubé NG, Coupland S, Gibbons RJ, Wallace VA, Picketts DJ
Hum Mol Genet. 2009
PubMed ID: 19088125
PKC and MLCK-dependent, cytokine-induced rat coronary endothelial dysfunction.
Tinsley JH, Hunter FA, Childs EW
J Surg Res. 2009
PubMed ID: 18621396
The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC.
Ren L, Hong SH, Cassavaugh J, Osborne T, Chou AJ, Kim SY, Gorlick R, Hewitt SM, Khanna C
Oncogene. 2009
PubMed ID: 19060919
Zea mays annexins modulate cytosolic free Ca2+ and generate a Ca2+-permeable conductance.
Laohavisit A, Mortimer JC, Demidchik V, Coxon KM, Stancombe MA, Macpherson N, Brownlee C, Hofmann A, Webb AA, Miedema H, Battey NH, Davies JM
Plant Cell. 2009
PubMed ID: 19234085
Mutant gammaPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells.
Seki T, Shimahara T, Yamamoto K, Abe N, Amano T, Adachi N, Takahashi H, Kashiwagi K, Saito N, Sakai N
Neurobiol Dis. 2009
PubMed ID: 19041943
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW
Eur Arch Psychiatry Clin Neurosci. 2009
PubMed ID: 19165527
Experience on the Barnes spatial maze influences PKCgamma levels in the hippocampus.
Nithianantharajah J, Murphy M
Int J Neurosci. 2009
PubMed ID: 19466636
Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC.
Romero M, Jiménez R, Sánchez M, López-Sepúlveda R, Zarzuelo MJ, O'Valle F, Zarzuelo A, Pérez-Vizcaíno F, Duarte J
Atherosclerosis. 2009
PubMed ID: 18436224
Distinct roles of protein kinase C isoforms in myogenic constriction of rat posterior cerebral arteries.
Kashihara T, Nakayama K, Ishikawa T
J Pharmacol Sci. 2008
PubMed ID: 19057126
Ca(2+)-dependent protein kinase C isoforms are critical to estradiol 17beta-D-glucuronide-induced cholestasis in the rat.
Crocenzi FA, Sánchez Pozzi EJ, Ruiz ML, Zucchetti AE, Roma MG, Mottino AD, Vore M
Hepatology. 2008
PubMed ID: 18972403
mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice.
Liu JX, Tang YC, Liu Y, Tang FR
Epilepsy Res. 2008
PubMed ID: 18774262
Dual regulation of the cardiac L-type calcium channel in L6 cells by protein kinase C.
Tafti BA, Hantash BM
Cell Calcium. 2008
PubMed ID: 18456322
Nonclassical mechanisms of progesterone action in the brain: I. Protein kinase C activation in the hypothalamus of female rats.
Balasubramanian B, Portillo W, Reyna A, Chen JZ, Moore AN, Dash PK, Mani SK
Endocrinology. 2008
PubMed ID: 18617608
Isoflurane inhibits protein kinase Cgamma and calcium/calmodulin dependent protein kinase ii-alpha translocation to synaptic membranes in ischemic mice brains.
Matsumoto S, Murozono M, Nagaoka D, Matsuoka S, Takeda A, Narita H, Watanabe S, Isshiki A, Watanabe Y
Neurochem Res. 2008
PubMed ID: 18473171
Ethanol regulation of D(1) dopamine receptor signaling is mediated by protein kinase C in an isozyme-specific manner.
Rex EB, Rankin ML, Ariano MA, Sibley DR
Neuropsychopharmacology. 2008
PubMed ID: 18288091
Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex.
Joshi PS, Molyneaux BJ, Feng L, Xie X, Macklis JD, Gan L
Neuron. 2008
PubMed ID: 18957218
NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors.
Rodríguez-Muñoz M, de la Torre-Madrid E, Sánchez-Blázquez P, Wang JB, Garzón J
Cell Signal. 2008
PubMed ID: 18652891
Cerebellar development transcriptome database (CDT-DB): Profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum.
Sato A, Sekine Y, Saruta C, Nishibe H, Morita N, Sato Y, Sadakata T, Shinoda Y, Kojima T, Furuichi T
Neural Netw. 2008
PubMed ID: 18603407
Rac regulates the interaction of fascin with protein kinase C in cell migration.
Parsons M, Adams JC
J Cell Sci. 2008
PubMed ID: 18716283
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers.
Neumann S, Braz JM, Skinner K, Llewellyn-Smith IJ, Basbaum AI
J Neurosci. 2008
PubMed ID: 18685019
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation.
Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T
Nat Neurosci. 2008
PubMed ID: 18641643
Activation of mutant protein kinase Cgamma leads to aberrant sequestration and impairment of its cellular function.
Doran G, Davies KE, Talbot K
Biochem Biophys Res Commun. 2008
PubMed ID: 18503760
PKC gamma mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling.
Verbeek DS, Goedhart J, Bruinsma L, Sinke RJ, Reits EA
J Cell Sci. 2008
PubMed ID: 18577575
Enzymological analysis of mutant protein kinase Cgamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis.
Adachi N, Kobayashi T, Takahashi H, Kawasaki T, Shirai Y, Ueyama T, Matsuda T, Seki T, Sakai N, Saito N
J Biol Chem. 2008
PubMed ID: 18499672
Neurochemical characterization of neuronal populations expressing protein kinase C gamma isoform in the spinal cord and gracile nucleus of the rat.
Hughes AS, Averill S, King VR, Molander C, Shortland PJ
Neuroscience. 2008
PubMed ID: 18387748
Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice.
Holstege JC, de Graaff W, Hossaini M, Cano SC, Jaarsma D, van den Akker E, Deschamps J
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18430798
Implication of spinal protein kinase Cgamma isoform in activation of the mouse brain by intrathecal injection of the protein kinase C activator phorbol 12,13-dibutyrate using functional magnetic resonance imaging analysis.
Niikura K, Kobayashi Y, Okutsu D, Furuya M, Kawano K, Maitani Y, Suzuki T, Narita M
Neurosci Lett. 2008
PubMed ID: 18242849
[Effects of lead exposure on protein kinase C and calmodulin expression in hippocampus and neurobehavioral function of baby rats].
Wang FS, Liu ZH, Zhang JS, Di JR
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008
PubMed ID: 18761789
Pbx3 is required for normal locomotion and dorsal horn development.
Rottkamp CA, Lobur KJ, Wladyka CL, Lucky AK, O'Gorman S
Dev Biol. 2008
PubMed ID: 18155191
Dlx2 homeobox gene transcriptional regulation of Trkb neurotrophin receptor expression during mouse retinal development.
de Melo J, Zhou QP, Zhang Q, Zhang S, Fonseca M, Wigle JT, Eisenstat DD
Nucleic Acids Res. 2008
PubMed ID: 18086710
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.
Ikeda A, Miyazaki T, Kakizawa S, Okuno Y, Tsuchiya S, Myomoto A, Saito SY, Yamamoto T, Yamazaki T, Iino M, Tsujimoto G, Watanabe M, Takeshima H
Biochem Biophys Res Commun. 2007
PubMed ID: 17904530
Benign SCA14 phenotype in a German patient associated with a missense mutation in exon 3 of the PRKCG gene.
Wieczorek S, Arning L, Gizewski ER, Alheite I, Timmann D
Mov Disord. 2007
PubMed ID: 17708558
Codon 101 of PRKCG, a preferential mutation site in SCA14.
Nolte D, Klebe S, Baron R, Deuschl G, Müller U
Mov Disord. 2007
PubMed ID: 17659643
Protein kinase C as a stress sensor.
Barnett ME, Madgwick DK, Takemoto DJ
Cell Signal. 2007
PubMed ID: 17629453
Dkk3-Cre BAC transgenic mouse line: a tool for highly efficient gene deletion in retinal progenitor cells.
Sato S, Inoue T, Terada K, Matsuo I, Aizawa S, Tano Y, Fujikado T, Furukawa T
Genesis. 2007
PubMed ID: 17661397
Another mutation in cysteine 131 in protein kinase C gamma as a cause of spinocerebellar ataxia type 14.
Klebe S, Faivre L, Forlani S, Dussert C, Tourbah A, Brice A, Stevanin G, Durr A
Arch Neurol. 2007
PubMed ID: 17562946
The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibition.
Schlaepfer IR, Clegg HV, Corley RP, Crowley TJ, Hewitt JK, Hopfer CJ, Krauter K, Lessem J, Rhee SH, Stallings MC, Wehner JM, Young SE, Ehringer MA
Addict Biol. 2007
PubMed ID: 17508994
Impaired motor learning in the vestibulo-ocular reflex in mice with multiple climbing fiber input to cerebellar Purkinje cells.
Kimpo RR, Raymond JL
J Neurosci. 2007
PubMed ID: 17522312
PRKCG mutation (SCA-14) causing a Ramsay Hunt phenotype.
Visser JE, Bloem BR, van de Warrenburg BP
Mov Disord. 2007
PubMed ID: 17343273
Regulation of insulin receptor function.
Youngren JF
Cell Mol Life Sci. 2007
PubMed ID: 17347799
PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression.
Gomes AR, Correia SS, Esteban JA, Duarte CB, Carvalho AL
Traffic. 2007
PubMed ID: 17233759
Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM
Mol Cell Proteomics. 2007
PubMed ID: 17114649
aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb.
Smith CA, Lau KM, Rahmani Z, Dho SE, Brothers G, She YM, Berry DM, Bonneil E, Thibault P, Schweisguth F, Le Borgne R, McGlade CJ
EMBO J. 2007
PubMed ID: 17203073
Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation.
Tu X, Joeng KS, Nakayama KI, Nakayama K, Rajagopal J, Carroll TJ, McMahon AP, Long F
Dev Cell. 2007
PubMed ID: 17199045
PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.
Yoshida Y, Han B, Mendelsohn M, Jessell TM
Neuron. 2006
PubMed ID: 17145500
R659S mutation of gammaPKC is susceptible to cell death: implication of this mutation/polymorphism in the pathogenesis of retinitis pigmentosa.
Mochizuki H, Seki T, Adachi N, Saito N, Mishima HK, Sakai N
Neurochem Int. 2006
PubMed ID: 16828200
PKCgamma knockout mouse lenses are more susceptible to oxidative stress damage.
Lin D, Barnett M, Lobell S, Madgwick D, Shanks D, Willard L, Zampighi GA, Takemoto DJ
J Exp Biol. 2006
PubMed ID: 17050852
Microarray analysis of the effects of a gamma-protein kinase C null mutation on gene expression in striatum: a role for transthyretin in mutant phenotypes.
Smith AM, Bowers BJ, Radcliffe RA, Wehner JM
Behav Genet. 2006
PubMed ID: 16767509
Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma.
Yamaguchi Y, Shirai Y, Matsubara T, Sanse K, Kuriyama M, Oshiro N, Yoshino K, Yonezawa K, Ono Y, Saito N
J Biol Chem. 2006
PubMed ID: 16905533
Preconditioning by 17beta-estradiol in isolated rat heart depends on PI3-K/PKB pathway, PKC, and ROS.
Sovershaev MA, Egorina EM, Andreasen TV, Jonassen AK, Ytrehus K
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16648180
Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy.
Pontier SM, Lahaie N, Ginham R, St-Gelais F, Bonin H, Bell DJ, Flynn H, Trudeau LE, McIlhinney J, White JH, Bouvier M
EMBO J. 2006
PubMed ID: 16724110
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY
Cell. 2006
PubMed ID: 16713569
Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT
Hum Mol Genet. 2006
PubMed ID: 16537572
Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening.
Li MZ, Wang JS, Jiang DJ, Xiang CX, Wang FY, Zhang KH, Williams PR, Chen ZF
Dev Biol. 2006
PubMed ID: 16516881
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Synergistic control of protein kinase Cgamma activity by ionotropic and metabotropic glutamate receptor inputs in hippocampal neurons.
Codazzi F, Di Cesare A, Chiulli N, Albanese A, Meyer T, Zacchetti D, Grohovaz F
J Neurosci. 2006
PubMed ID: 16571747
Protein kinase C attenuates beta-adrenergic receptor-mediated lipolysis, probably through inhibition of the beta1-adrenergic receptor system.
Nakamura J
Arch Biochem Biophys. 2006
PubMed ID: 16500613
Protein kinase Cgamma regulates myosin IIB phosphorylation, cellular localization, and filament assembly.
Rosenberg M, Ravid S
Mol Biol Cell. 2006
PubMed ID: 16394101
Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain.
Chen CL, Broom DC, Liu Y, de Nooij JC, Li Z, Cen C, Samad OA, Jessell TM, Woolf CJ, Ma Q
Neuron. 2006
PubMed ID: 16446141
Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile response.
Westfall MV, Lee AM, Robinson DA
J Biol Chem. 2005
PubMed ID: 16236710
Deficits in the mid-brain raphe nuclei and striatum of the AS/AGU rat, a protein kinase C-gamma mutant.
Al-Fayez M, Russell D, Wayne Davies R, Shiels PG, Baker PJ, Payne AP
Eur J Neurosci. 2005
PubMed ID: 16324113
Relative contribution of cell contact pattern, specific PKC isoforms and gap junctional communication in tight junction assembly in the mouse early embryo.
Eckert JJ, McCallum A, Mears A, Rumsby MG, Cameron IT, Fleming TP
Dev Biol. 2005
PubMed ID: 16271712
Expression of spinal NMDA receptor and PKCgamma after chronic morphine is regulated by spinal glucocorticoid receptor.
Lim G, Wang S, Zeng Q, Sung B, Yang L, Mao J
J Neurosci. 2005
PubMed ID: 16319314
New mutations in protein kinase Cgamma associated with spinocerebellar ataxia type 14.
Klebe S, Durr A, Rentschler A, Hahn-Barma V, Abele M, Bouslam N, Schöls L, Jedynak P, Forlani S, Denis E, Dussert C, Agid Y, Bauer P, Globas C, Wüllner U, Brice A, Riess O, Stevanin G
Ann Neurol. 2005
PubMed ID: 16193476
Roles of protein kinase C in regulation of P2X7 receptor-mediated calcium signalling of cultured type-2 astrocyte cell line, RBA-2.
Hung AC, Chu YJ, Lin YH, Weng JY, Chen HB, Au YC, Sun SH
Cell Signal. 2005
PubMed ID: 15985361
Expression profile of protein kinase C isozymes in preimplantation mouse development.
Dehghani H, Hahnel AC
Reproduction. 2005
PubMed ID: 16183862
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Generation and characterization of the PKC gamma-Cre mouse line.
Ding YQ, Xiang CX, Chen ZF
Genesis. 2005
PubMed ID: 16106361
Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death.
Seki T, Adachi N, Ono Y, Mochizuki H, Hiramoto K, Amano T, Matsubayashi H, Matsumoto M, Kawakami H, Saito N, Sakai N
J Biol Chem. 2005
PubMed ID: 15964845
PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.
Lu W, Ziff EB
Neuron. 2005
PubMed ID: 16055064
Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes.
Shumilla JA, Liron T, Mochly-Rosen D, Kendig JJ, Sweitzer SM
J Pain. 2005
PubMed ID: 16084468
Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction.
Boyle AJ, Kelly DJ, Zhang Y, Cox AJ, Gow RM, Way K, Itescu S, Krum H, Gilbert RE
J Mol Cell Cardiol. 2005
PubMed ID: 15878171
Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on Serine 839 regulates Ca2+ oscillations.
Kim CH, Braud S, Isaac JT, Roche KW
J Biol Chem. 2005
PubMed ID: 15894802
Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms.
Sánchez-Pérez AM, Felipo V
Neurochem Int. 2005
PubMed ID: 15936117
Insulin receptor-protein kinase C-gamma signaling mediates inhibition of hypoxia-induced necrosis of cortical neurons.
Hamabe W, Fujita R, Ueda H
J Pharmacol Exp Ther. 2005
PubMed ID: 15705736
Prolonged Alzheimer-like tau hyperphosphorylation induced by simultaneous inhibition of phosphoinositol-3 kinase and protein kinase C in N2a cells.
Xu GG, Deng YQ, Liu SJ, Li HL, Wang JZ
Acta Biochim Biophys Sin (Shanghai). 2005
PubMed ID: 15880264
The C2 domain of PKCdelta is a phosphotyrosine binding domain.
Benes CH, Wu N, Elia AE, Dharia T, Cantley LC, Soltoff SP
Cell. 2005
PubMed ID: 15851033
hMutS alpha is protected from ubiquitin-proteasome-dependent degradation by atypical protein kinase C zeta phosphorylation.
Hernandez-Pigeon H, Quillet-Mary A, Louat T, Schambourg A, Humbert O, Selves J, Salles B, Laurent G, Lautier D
J Mol Biol. 2005
PubMed ID: 15808853
Translocation of phospho-protein kinase Cs implies their roles in meiotic-spindle organization, polar-body emission and nuclear activity in mouse eggs.
Zheng ZY, Li QZ, Chen DY, Schatten H, Sun QY
Reproduction. 2005
PubMed ID: 15695617
Central glucocorticoid receptors modulate the expression and function of spinal NMDA receptors after peripheral nerve injury.
Wang S, Lim G, Zeng Q, Sung B, Yang L, Mao J
J Neurosci. 2005
PubMed ID: 15647493
Protein kinase C activity and isoform expression during early postnatal development of rat myocardium.
Hamplova B, Novakova O, Tvrzicka E, Kolar F, Novak F
Cell Biochem Biophys. 2005
PubMed ID: 16043888
Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120.
Langford D, Hurford R, Hashimoto M, Digicaylioglu M, Masliah E
BMC Neurosci. 2005
PubMed ID: 15689238
Distinctive activation mechanisms and functions for protein kinase Cdelta.
Steinberg SF
Biochem J. 2004
PubMed ID: 15491280
Inhibition of gap junction activity through the release of the C1B domain of protein kinase Cgamma (PKCgamma) from 14-3-3: identification of PKCgamma-binding sites.
Nguyen TA, Takemoto LJ, Takemoto DJ
J Biol Chem. 2004
PubMed ID: 15459208
Protein kinase C isoforms differentially phosphorylate human choline acetyltransferase regulating its catalytic activity.
Dobransky T, Doherty-Kirby A, Kim AR, Brewer D, Lajoie G, Rylett RJ
J Biol Chem. 2004
PubMed ID: 15381704
PKC signaling at fertilization in mammalian eggs.
Halet G
Biochim Biophys Acta. 2004
PubMed ID: 15590069
Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells.
Woo CH, Lim JH, Kim JH
J Immunol. 2004
PubMed ID: 15557194
Protein kinase C activity regulates the onset of anaphase I in mouse oocytes.
Viveiros MM, O'brien M, Eppig JJ
Biol Reprod. 2004
PubMed ID: 15229137
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101).
Li Y, Soos TJ, Li X, Wu J, Degennaro M, Sun X, Littman DR, Birnbaum MJ, Polakiewicz RD
J Biol Chem. 2004
PubMed ID: 15364919
Protein kinase Cdelta regulates apoptosis via activation of STAT1.
DeVries TA, Kalkofen RL, Matassa AA, Reyland ME
J Biol Chem. 2004
PubMed ID: 15322115
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Regulation of spontaneous meiosis resumption in mouse oocytes by various conventional PKC isozymes depends on cellular compartmentalization.
Avazeri N, Courtot AM, Lefevre B
J Cell Sci. 2004
PubMed ID: 15367584
Acute restraint stress reduces protein kinase C gamma in the hippocampus of C57BL/6 but not DBA/2 mice.
McNamara RK, Lenox RH
Neurosci Lett. 2004
PubMed ID: 15364414
Differential phosphorylation of connexin46 and connexin50 by H2O2 activation of protein kinase Cgamma.
Lin D, Lobell S, Jewell A, Takemoto DJ
Mol Vis. 2004
PubMed ID: 15467523
Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families.
Brusco A, Gellera C, Cagnoli C, Saluto A, Castucci A, Michielotto C, Fetoni V, Mariotti C, Migone N, Di Donato S, Taroni F
Arch Neurol. 2004
PubMed ID: 15148151
The DNA sequence and biology of human chromosome 19.
Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM
Nature. 2004
PubMed ID: 15057824
Activation of phospholipase C-gamma1 in human keratinocytes by hyperosmolar shock without enzyme phosphorylation.
Rodriguez I, Holloschi A, Kaszkin M, Cheng H, Kabsch K, Hafner M, Alonso A
Arch Dermatol Res. 2004
PubMed ID: 15014953
Conventional PKCs regulate the temporal pattern of Ca2+ oscillations at fertilization in mouse eggs.
Halet G, Tunwell R, Parkinson SJ, Carroll J
J Cell Biol. 2004
PubMed ID: 15051735
Association of CPI-17 with protein kinase C and casein kinase I.
Zemlickova E, Johannes FJ, Aitken A, Dubois T
Biochem Biophys Res Commun. 2004
PubMed ID: 15003508
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G
J Biol Chem. 2004
PubMed ID: 14676191
Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C.
Nery FC, Passos DO, Garcia VS, Kobarg J
J Biol Chem. 2004
PubMed ID: 14699138
The V5 domain of protein kinase C plays a critical role in determining the isoform-specific localization, translocation, and biological function of protein kinase C-delta and -epsilon.
Wang QJ, Lu G, Schlapkohl WA, Goerke A, Larsson C, Mischak H, Blumberg PM, Mushinski JF
Mol Cancer Res. 2004
PubMed ID: 14985469
Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase Cgamma gene.
Célérier E, Simonnet G, Maldonado R
Neuropharmacology. 2004
PubMed ID: 14680764
Isoform-specific phosphorylation of metabotropic glutamate receptor 5 by protein kinase C (PKC) blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKC.
Uchino M, Sakai N, Kashiwagi K, Shirai Y, Shinohara Y, Hirose K, Iino M, Yamamura T, Saito N
J Biol Chem. 2004
PubMed ID: 14561742
In vivo expression of classic PKC isoforms in the rat dental follicle as related to tooth eruption.
Yao S, Wise G
Connect Tissue Res. 2004
PubMed ID: 15763930
Protein kinase C-gamma and calcium/calmodulin-dependent protein kinase II-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion.
Matsumoto S, Shamloo M, Matsumoto E, Isshiki A, Wieloch T
J Cereb Blood Flow Metab. 2004
PubMed ID: 14688616
Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain.
Gardell LR, Ibrahim M, Wang R, Wang Z, Ossipov MH, Malan TP, Porreca F, Lai J
Neuroscience. 2004
PubMed ID: 14667440
Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol.
Cogram P, Hynes A, Dunlevy LP, Greene ND, Copp AJ
Hum Mol Genet. 2004
PubMed ID: 14613966
Identification of a novel SCA14 mutation in a Dutch autosomal dominant cerebellar ataxia family.
van de Warrenburg BP, Verbeek DS, Piersma SJ, Hennekam FA, Pearson PL, Knoers NV, Kremer HP, Sinke RJ
Neurology. 2003
PubMed ID: 14694043
Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2.
Lorenz K, Lohse MJ, Quitterer U
Nature. 2003
PubMed ID: 14654844
Open field activity and EtOH activation of gamma-PKC null mutants.
Hix DM, Bowers BJ, Miyamoto JH, Wehner JM
Addict Biol. 2003
PubMed ID: 14690876
Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C gamma.
Yabe I, Sasaki H, Chen DH, Raskind WH, Bird TD, Yamashita I, Tsuji S, Kikuchi S, Tashiro K
Arch Neurol. 2003
PubMed ID: 14676051
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains.
Ananthanarayanan B, Stahelin RV, Digman MA, Cho W
J Biol Chem. 2003
PubMed ID: 12954613
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ
Science. 2003
PubMed ID: 12958364
Physiological regulation of Munc18/nSec1 phosphorylation on serine-313.
Craig TJ, Evans GJ, Morgan A
J Neurochem. 2003
PubMed ID: 12950453
Role of protein kinase C family in the cerebellum-dependent adaptive learning of horizontal optokinetic response eye movements in mice.
Shutoh F, Katoh A, Ohki M, Itohara S, Tonegawa S, Nagao S
Eur J Neurosci. 2003
PubMed ID: 12859346
Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin.
Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM
Mol Cell Biol. 2003
PubMed ID: 12832475
EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland.
Koyama N, Kashimata M, Sakashita H, Sakagami H, Gresik EW
Dev Dyn. 2003
PubMed ID: 12761849
Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.
Chikamori K, Grabowski DR, Kinter M, Willard BB, Yadav S, Aebersold RH, Bukowski RM, Hickson ID, Andersen AH, Ganapathi R, Ganapathi MK
J Biol Chem. 2003
PubMed ID: 12569090
Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein.
Corbit KC, Trakul N, Eves EM, Diaz B, Marshall M, Rosner MR
J Biol Chem. 2003
PubMed ID: 12551925
Ethanol differentially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice.
Proctor WR, Poelchen W, Bowers BJ, Wehner JM, Messing RO, Dunwiddie TV
J Pharmacol Exp Ther. 2003
PubMed ID: 12649378
Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia.
Chen DH, Brkanac Z, Verlinde CL, Tan XJ, Bylenok L, Nochlin D, Matsushita M, Lipe H, Wolff J, Fernandez M, Cimino PJ, Bird TD, Raskind WH
Am J Hum Genet. 2003
PubMed ID: 12644968
Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis.
Barclay JW, Craig TJ, Fisher RJ, Ciufo LF, Evans GJ, Morgan A, Burgoyne RD
J Biol Chem. 2003
PubMed ID: 12519779
Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation.
Correia SS, Duarte CB, Faro CJ, Pires EV, Carvalho AL
J Biol Chem. 2003
PubMed ID: 12471040
Protein kinase C is involved in clozapine's facilitation of N-methyl-D-aspartate- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex.
Jardemark KE, Ninan I, Liang X, Wang RY
Neuroscience. 2003
PubMed ID: 12699785
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E
Virology. 2002
PubMed ID: 12482669
Protein kinase C gamma (PKC gamma): function of neuron specific isotype.
Saito N, Shirai Y
J Biochem. 2002
PubMed ID: 12417016
Influence of a deletion of protein kinase C gamma isoform in the G-protein activation mediated through opioid receptor-like-1 and mu-opioid receptors in the mouse pons/medulla.
Narita M, Mizoguchi H, Khotib J, Suzuki M, Ozaki S, Yajima Y, Narita M, Tseng LF, Suzuki T
Neurosci Lett. 2002
PubMed ID: 12359310
A new dominant spinocerebellar ataxia linked to chromosome 19q13.4-qter.
Brkanac Z, Bylenok L, Fernandez M, Matsushita M, Lipe H, Wolff J, Nochlin D, Raskind WH, Bird TD
Arch Neurol. 2002
PubMed ID: 12164726
Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII.
Mayadevi M, Praseeda M, Kumar KS, Omkumar RV
Biochim Biophys Acta. 2002
PubMed ID: 12147342
PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments.
Qian Y, Baisden JM, Cherezova L, Summy JM, Guappone-Koay A, Shi X, Mast T, Pustula J, Zot HG, Mazloum N, Lee MY, Flynn DC
Mol Biol Cell. 2002
PubMed ID: 12134071
Association of protein kinase C with GABA(A) receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption.
Kumar S, Sieghart W, Morrow AL
J Neurochem. 2002
PubMed ID: 12091471
Phosphorylation of the recombinant rho1 GABA receptor.
Sedelnikova A, Weiss DS
Int J Dev Neurosci. 2002
PubMed ID: 12175859
The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions.
Slater SJ, Ho C, Stubbs CD
Chem Phys Lipids. 2002
PubMed ID: 12093536
Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction.
Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S
Biochem Biophys Res Commun. 2002
PubMed ID: 12054501
HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta.
Bennasser Y, Bahraoui E
FASEB J. 2002
PubMed ID: 11919157
Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
Fang X, Yu S, Tanyi JL, Lu Y, Woodgett JR, Mills GB
Mol Cell Biol. 2002
PubMed ID: 11884598
Regulation of phospholipase C-gamma1 by protein kinase A-dependent phosphorylation.
Bae SS, Choi JH, Oh YS, Yun SU, Ryu SH, Suh PG
Adv Enzyme Regul. 2002
PubMed ID: 12123716
Individual differences in spatial memory among aged rats are related to hippocampal PKCgamma immunoreactivity.
Colombo PJ, Gallagher M
Hippocampus. 2002
PubMed ID: 12000125
Altered dendritic development of cerebellar Purkinje cells in slice cultures from protein kinase Cgamma-deficient mice.
Schrenk K, Kapfhammer JP, Metzger F
Neuroscience. 2002
PubMed ID: 11934475
Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice.
Zeitz KP, Malmberg AB, Gilbert H, Basbaum AI
Pain. 2001
PubMed ID: 11731061
Ethanol consumption and behavioral impulsivity are increased in protein kinase Cgamma null mutant mice.
Bowers BJ, Wehner JM
J Neurosci. 2001
PubMed ID: 11606660
Reduced hyperalgesia induced by nerve injury, but not by inflammation in mice lacking protein kinase C gamma isoform.
Ohsawa M, Narita M, Mizoguchi H, Cheng E, Tseng LF
Eur J Pharmacol. 2001
PubMed ID: 11698038
Protein kinase C regulates the phosphorylation and cellular localization of occludin.
Andreeva AY, Krause E, Müller EC, Blasig IE, Utepbergenov DI
J Biol Chem. 2001
PubMed ID: 11502742
Altered trafficking of membrane proteins in purkinje cells of SCA1 transgenic mice.
Skinner PJ, Vierra-Green CA, Clark HB, Zoghbi HY, Orr HT
Am J Pathol. 2001
PubMed ID: 11549583
Age-dependent activation of PKC isoforms by angiotensin II in the proximal nephron.
Boesch DM, Garvin JL
Am J Physiol Regul Integr Comp Physiol. 2001
PubMed ID: 11507002
HIV envelope gp120 activates human arterial smooth muscle cells.
Schecter AD, Berman AB, Yi L, Mosoian A, McManus CM, Berman JW, Klotman ME, Taubman MB
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11504923
Glycogen synthase kinase-3: properties, functions, and regulation.
Ali A, Hoeflich KP, Woodgett JR
Chem Rev. 2001
PubMed ID: 11749387
The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord.
Chen ZF, Rebelo S, White F, Malmberg AB, Baba H, Lima D, Woolf CJ, Basbaum AI, Anderson DJ
Neuron. 2001
PubMed ID: 11498051
PKCgamma contributes to a subset of the NMDA-dependent spinal circuits that underlie injury-induced persistent pain.
Martin WJ, Malmberg AB, Basbaum AI
J Neurosci. 2001
PubMed ID: 11438608
Enhanced mu-opioid responses in the spinal cord of mice lacking protein kinase Cgamma isoform.
Narita M, Mizoguchi H, Suzuki T, Narita M, Dun NJ, Imai S, Yajima Y, Nagase H, Suzuki T, Tseng LF
J Biol Chem. 2001
PubMed ID: 11278552
Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current.
Liao GY, Wagner DA, Hsu MH, Leonard JP
Mol Pharmacol. 2001
PubMed ID: 11306676
Regulation of the ErbB3 binding protein Ebp1 by protein kinase C.
Lessor TJ, Hamburger AW
Mol Cell Endocrinol. 2001
PubMed ID: 11325528
Activation of annexin 7 by protein kinase C in vitro and in vivo.
Caohuy H, Pollard HB
J Biol Chem. 2001
PubMed ID: 11278415
Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.
Cunningham ML, Waldo GL, Hollinger S, Hepler JR, Harden TK
J Biol Chem. 2001
PubMed ID: 11063746
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.
Burgess DL, Gefrides LA, Foreman PJ, Noebels JL
Genomics. 2001
PubMed ID: 11170751
Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin.
Krasel C, Dammeier S, Winstel R, Brockmann J, Mischak H, Lohse MJ
J Biol Chem. 2001
PubMed ID: 11042191
HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.
Park IW, Wang JF, Groopman JE
Blood. 2001
PubMed ID: 11154208
[HIV-1 Tat protein induces IL-10 production by human monocytes: implications of the PKC and calcium pathway]
Bennasser Y, Yamina B, Contreras X, Xavier C, Moreau M, Marc M, Le Clerc C, Catherine L, Badou A, Abdallah B, Bahraoui E
J Soc Biol. 2001
PubMed ID: 11833470
Involvement of protein kinase Cgamma isoform in morphine-induced reinforcing effects.
Narita M, Aoki T, Ozaki S, Yajima Y, Suzuki T
Neuroscience. 2001
PubMed ID: 11246146
Role of two conserved cytoplasmic threonine residues (T410 and T412) in CD5 signaling.
Vilà JM, Calvo J, Places L, Padilla O, Arman M, Gimferrer I, Aussel C, Vives J, Lozano F
J Immunol. 2001
PubMed ID: 11123317
Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium.
Huang MB, Bond VC
J Acquir Immune Defic Syndr. 2000
PubMed ID: 11141237
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway.
Badou A, Bennasser Y, Moreau M, Leclerc C, Benkirane M, Bahraoui E
J Virol. 2000
PubMed ID: 11044099
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.
Fang X, Yu SX, Lu Y, Bast RC, Woodgett JR, Mills GB
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11035810
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genes encoding troponin I and troponin T are organized as three paralogous pairs in the mouse genome.
Barton PJ, Mullen AJ, Cullen ME, Dhoot GK, Simon-Chazottes D, Guénet JL
Mamm Genome. 2000
PubMed ID: 11003710
Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets.
Chung SH, Polgar J, Reed GL
J Biol Chem. 2000
PubMed ID: 10856305
A novel locus for dominant cerebellar ataxia (SCA14) maps to a 10.2-cM interval flanked by D19S206 and D19S605 on chromosome 19q13.4-qter.
Yamashita I, Sasaki H, Yabe I, Fukazawa T, Nogoshi S, Komeichi K, Takada A, Shiraishi K, Takiyama Y, Nishizawa M, Kaneko J, Tanaka H, Tsuji S, Tashiro K
Ann Neurol. 2000
PubMed ID: 10939565
The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development.
Pauken CM, Capco DG
Dev Biol. 2000
PubMed ID: 10882525
Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.
Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG
Nat Neurosci. 2000
PubMed ID: 10862698
Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication.
Lampe PD, TenBroek EM, Burt JM, Kurata WE, Johnson RG, Lau AF
J Cell Biol. 2000
PubMed ID: 10871288
Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.
Mayne M, Holden CP, Nath A, Geiger JD
J Immunol. 2000
PubMed ID: 10843712
Learning deficiency and alterations in acetylcholine receptors and protein kinase C in the brain of senescence-accelerated mouse (SAM)-P10.
Okuma Y, Murayama T, Tha KK, Yamada C, Hosokawa M, Ishikawa A, Watanabe R, Maekawa M, Nomura Y
Mech Ageing Dev. 2000
PubMed ID: 10802123
Dissection of behavior and psychiatric disorders using the mouse as a model.
Tarantino LM, Bucan M
Hum Mol Genet. 2000
PubMed ID: 10767319
Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling.
Fraser ID, Cong M, Kim J, Rollins EN, Daaka Y, Lefkowitz RJ, Scott JD
Curr Biol. 2000
PubMed ID: 10753752
Mice lacking PKC gamma exhibit decreased anxiety.
Bowers BJ, Collins AC, Tritto T, Wehner JM
Behav Genet. 2000
PubMed ID: 10979601
Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development.
Balasubramanian G, Amann JF, Reddy CS
J Craniofac Genet Dev Biol. 2000
PubMed ID: 10879655
A synthetic peptide derived from the non-structural protein 3 of hepatitis C virus serves as a specific substrate for PKC.
Borowski P, Resch K, Schmitz H, Heiland M
Biol Chem. 2000
PubMed ID: 10722046
Phosphorylation of HMG-I by protein kinase C attenuates its binding affinity to the promoter regions of protein kinase C gamma and neurogranin/RC3 genes.
Xiao DM, Pak JH, Wang X, Sato T, Huang FL, Chen HC, Huang KP
J Neurochem. 2000
PubMed ID: 10617144
HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system.
Idriss H, Kawa S, Damuni Z, Thompson EB, Wilson SH
Int J Biochem Cell Biol. 1999
PubMed ID: 10641798
The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer.
Tseng CP, Ely BD, Pong RC, Wang Z, Zhou J, Hsieh JT
J Biol Chem. 1999
PubMed ID: 10542228
Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch.
Santy LC, Frank SR, Hatfield JC, Casanova JE
Curr Biol. 1999
PubMed ID: 10531036
Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates.
Tözsér J, Bagossi P, Boross P, Louis JM, Majerova E, Oroszlan S, Copeland TD
Eur J Biochem. 1999
PubMed ID: 10491200
No mutations in the coding region of the PRKCG gene in three families with retinitis pigmentosa linked to the RP11 locus on chromosome 19q.
Dryja TP, McEvoy J, McGee TL, Berson EL
Am J Hum Genet. 1999
PubMed ID: 10441600
alpha-Synuclein shares physical and functional homology with 14-3-3 proteins.
Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B
J Neurosci. 1999
PubMed ID: 10407019
Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C.
Zhou Q, Ruiz-Lozano P, Martone ME, Chen J
J Biol Chem. 1999
PubMed ID: 10391924
14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells.
Autieri MV, Carbone CJ
DNA Cell Biol. 1999
PubMed ID: 10433554
Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation.
Fleming IN, Elliott CM, Buchanan FG, Downes CP, Exton JH
J Biol Chem. 1999
PubMed ID: 10212259
Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion.
Reed GL, Houng AK, Fitzgerald ML
Blood. 1999
PubMed ID: 10194441
Decreased ethanol sensitivity and tolerance development in gamma-protein kinase C null mutant mice is dependent on genetic background.
Bowers BJ, Owen EH, Collins AC, Abeliovich A, Tonegawa S, Wehner JM
Alcohol Clin Exp Res. 1999
PubMed ID: 10195808
Substrate phosphorylation in the protein kinase Cgamma knockout mouse.
Ramakers GM, Gerendasy DD, de Graan PN
J Biol Chem. 1999
PubMed ID: 9890937
Protein kinase C-theta is specifically localized on centrosomes and kinetochores in mitotic cells.
Passalacqua M, Patrone M, Sparatore B, Melloni E, Pontremoli S
Biochem J. 1999
PubMed ID: 9854032
The ultraviolet studies on protein-lipid interaction of a protein kinase C-gamma phorbol-binding domain.
Kowara R, Gryckiewicz E, Matecki A, Pawelczyk T
Acta Biochim Pol. 1999
PubMed ID: 10547041
Characterisation of non-structural protein 3 of hepatitis C virus as modulator of protein phosphorylation mediated by PKA and PKC: evidences for action on the level of substrate and enzyme.
Borowski P, Heiland M, Feucht H, Laufs R
Arch Virol. 1999
PubMed ID: 10365161
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Inflammation-induced up-regulation of protein kinase Cgamma immunoreactivity in rat spinal cord correlates with enhanced nociceptive processing.
Martin WJ, Liu H, Wang H, Malmberg AB, Basbaum AI
Neuroscience. 1999
PubMed ID: 10336135
Characterization of the mouse Src homology 3 domain gene Sh3d2c on Chr 7 demonstrates coexpression with huntingtin in the brain and identifies the processed pseudogene Sh3d2c-ps1 on Chr 2.
Zechner U, Scheel S, Hemberger M, Hopp M, Haaf T, Fundele R, Wanker EE, Lehrach H, Wedemeyer N, Himmelbauer H
Genomics. 1998
PubMed ID: 9878254
A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.
Izumi Y, Hirata M, Hasuwa H, Iwamoto R, Umata T, Miyado K, Tamai Y, Kurisaki T, Sehara-Fujisawa A, Ohno S, Mekada E
EMBO J. 1998
PubMed ID: 9857183
Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals.
Oancea E, Meyer T
Cell. 1998
PubMed ID: 9814702
Distinct effects of fatty acids on translocation of gamma- and epsilon-subspecies of protein kinase C.
Shirai Y, Kashiwagi K, Yagi K, Sakai N, Saito N
J Cell Biol. 1998
PubMed ID: 9786959
Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure.
Mahadev K, Vemuri MC
Arch Biochem Biophys. 1998
PubMed ID: 9705215
Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release.
Bai M, Trivedi S, Lane CR, Yang Y, Quinn SJ, Brown EM
J Biol Chem. 1998
PubMed ID: 9694886
Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways.
Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F
AIDS Res Hum Retroviruses. 1998
PubMed ID: 9671211
Alzheimer's-specific effects of soluble beta-amyloid on protein kinase C-alpha and -gamma degradation in human fibroblasts.
Favit A, Grimaldi M, Nelson TJ, Alkon DL
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9576922
Segregation of a PRKCG mutation in two RP11 families.
Al-Maghtheh M, Vithana EN, Inglehearn CF, Moore T, Bird AC, Bhattacharya SS
Am J Hum Genet. 1998
PubMed ID: 9545390
Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins.
Tokunaga C, Kuroda S, Tatematsu K, Nakagawa N, Ono Y, Kikkawa U
Biochem Biophys Res Commun. 1998
PubMed ID: 9514928
Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.
Borgatti P, Zauli G, Cantley LC, Capitani S
Biochem Biophys Res Commun. 1998
PubMed ID: 9446795
Evidence that the penetrance of mutations at the RP11 locus causing dominant retinitis pigmentosa is influenced by a gene linked to the homologous RP11 allele.
McGee TL, Devoto M, Ott J, Berson EL, Dryja TP
Am J Hum Genet. 1997
PubMed ID: 9345108
Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma.
Malmberg AB, Chen C, Tonegawa S, Basbaum AI
Science. 1997
PubMed ID: 9323205
NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions.
Xu RX, Pawelczyk T, Xia TH, Brown SC
Biochemistry. 1997
PubMed ID: 9271501
Serine phosphorylation of syndecan-2 proteoglycan cytoplasmic domain.
Oh ES, Couchman JR, Woods A
Arch Biochem Biophys. 1997
PubMed ID: 9244383
The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4.
Kim J, Ashworth L, Branscomb E, Stubbs L
Genome Res. 1997
PubMed ID: 9149948
The gene encoding the Schwann cell protein periaxin localizes on mouse chromosome 7 (Prx).
Gillespie CS, Lee M, Fantes JF, Brophy PJ
Genomics. 1997
PubMed ID: 9143514
ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes.
Liu D, Pavlopoulos E, Modi W, Moschonas N, Mavrothalassitis G
Oncogene. 1997
PubMed ID: 9136988
Phosphorylation of vitronectin on Ser362 by protein kinase C attenuates its cleavage by plasmin.
Gechtman Z, Shaltiel S
Eur J Biochem. 1997
PubMed ID: 9030777
Exposure to chronic psychosocial stress and corticosterone in the rat: effects on spatial discrimination learning and hippocampal protein kinase Cgamma immunoreactivity.
Krugers HJ, Douma BR, Andringa G, Bohus B, Korf J, Luiten PG
Hippocampus. 1997
PubMed ID: 9287082
Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor.
Omkumar RV, Kiely MJ, Rosenstein AJ, Min KT, Kennedy MB
J Biol Chem. 1996
PubMed ID: 8940188
Protein-protein interaction of zinc finger LIM domains with protein kinase C.
Kuroda S, Tokunaga C, Kiyohara Y, Higuchi O, Konishi H, Mizuno K, Gill GN, Kikkawa U
J Biol Chem. 1996
PubMed ID: 8940095
The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.
Zappelli F, Willems D, Osada S, Ohno S, Wetsel WC, Molinaro M, Cossu G, Bouché M
Dev Biol. 1996
PubMed ID: 8948582
Spinocerebellar mossy fiber terminal topography in the NR2C/PKC gamma double mutant cerebellum.
Ji Z, Ebralidze A, Tonegawa S, Vogel MW
Brain Res Dev Brain Res. 1996
PubMed ID: 8946062
In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46.
Holmes AM
Arch Biochem Biophys. 1996
PubMed ID: 8914829
Developmental expression of MARCKS and protein kinase C in mice in relation to the exencephaly resulting from MARCKS deficiency.
Blackshear PJ, Lai WS, Tuttle JS, Stumpo DJ, Kennington E, Nairn AC, Sulik KK
Brain Res Dev Brain Res. 1996
PubMed ID: 8922669
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Genetic maps of polymorphic DNA loci on rat chromosome 1.
Ding YP, Remmers EF, Du Y, Longman RE, Goldmuntz EA, Zha H, Kotake S, Cannon GW, Griffiths MM, Wilder RL
Genomics. 1996
PubMed ID: 8812459
Detailed comparative map of human chromosome 19q and related regions of the mouse genome.
Stubbs L, Carver EA, Shannon ME, Kim J, Geisler J, Generoso EE, Stanford BG, Dunn WC, Mohrenweiser H, Zimmermann W, Watt SM, Ashworth LK
Genomics. 1996
PubMed ID: 8812484
Pathways for degradation of the catalytic subunit of cAMP-dependent protein kinase differ in wild-type and kinase-negative S49 mouse lymphoma cells.
Lee SL, Steinberg RA
J Biol Chem. 1996
PubMed ID: 8663257
Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins.
Whalen SG, Gingras AC, Amankwa L, Mader S, Branton PE, Aebersold R, Sonenberg N
J Biol Chem. 1996
PubMed ID: 8662663
Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin.
Fujita Y, Sasaki T, Fukui K, Kotani H, Kimura T, Hata Y, Südhof TC, Scheller RH, Takai Y
J Biol Chem. 1996
PubMed ID: 8631738
Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors.
Ishikawa TO, Tamai Y, Rochelle JM, Hirata M, Namba T, Sugimoto Y, Ichikawa A, Narumiya S, Taketo MM, Seldin MF
Genomics. 1996
PubMed ID: 8833158
Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes.
Conant K, Ma M, Nath A, Major EO
J Virol. 1996
PubMed ID: 8627654
IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C.
Parada NA, Cruikshank WW, Danis HL, Ryan TC, Center DM
Cell Immunol. 1996
PubMed ID: 8599832
Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice.
Chen C, Kano M, Abeliovich A, Chen L, Bao S, Kim JJ, Hashimoto K, Thompson RF, Tonegawa S
Cell. 1995
PubMed ID: 8548809
Impaired synapse elimination during cerebellar development in PKC gamma mutant mice.
Kano M, Hashimoto K, Chen C, Abeliovich A, Aiba A, Kurihara H, Watanabe M, Inoue Y, Tonegawa S
Cell. 1995
PubMed ID: 8548808
Mapping TNNC1, the gene that encodes cardiac troponin I in the human and the mouse.
Bermingham N, Hernandez D, Balfour A, Gilmour F, Martin JE, Fisher EM
Genomics. 1995
PubMed ID: 8825654
Cell cycle phase-specific phosphorylation of human topoisomerase II alpha. Evidence of a role for protein kinase C.
Wells NJ, Fry AM, Guano F, Norbury C, Hickson ID
J Biol Chem. 1995
PubMed ID: 7499337
Mapping of four mouse genes encoding eye lens-specific structural, gap junction, and integral membrane proteins: Cryba1 (crystallin beta A3/A1), Crybb2 (crystallin beta B2), Gja8 (MP70), and Lim2 (MP19).
Kerscher S, Church RL, Boyd Y, Lyon MF
Genomics. 1995
PubMed ID: 8666393
HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells.
Chirmule N, Goonewardena H, Pahwa S, Pasieka R, Kalyanaraman VS, Pahwa S
J Biol Chem. 1995
PubMed ID: 7642615
A contravention of Ohno's law in mice.
Palmer S, Perry J, Ashworth A
Nat Genet. 1995
PubMed ID: 7670497
Functional characterization of the promoter region of the mouse protein kinase C gamma gene.
Takanaga H, Mukai H, Shimakawa M, Konishi H, Kikkawa U, Koizumi T, Ono Y
FEBS Lett. 1995
PubMed ID: 7628620
Protein and molecular characterization of hippocampal protein kinase C in C57BL/6 and DBA/2 mice.
Bowers BJ, Christensen SC, Pauley JR, Paylor R, Yuva L, Dunbar SE, Wehner JM
J Neurochem. 1995
PubMed ID: 7760054
Distribution of the extended family of protein kinase C isoenzymes in fetal organs of mice: an immunohistochemical study.
Bareggi R, Grill V, Zweyer M, Narducci P, Martelli AM
Cell Tissue Res. 1995
PubMed ID: 7606770
Mutant mice lacking the gamma isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of gamma-aminobutyrate type A receptors.
Harris RA, McQuilkin SJ, Paylor R, Abeliovich A, Tonegawa S, Wehner JM
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7731960
Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein.
Ward NE, Gravitt KR, O'Brian CA
Cancer Lett. 1995
PubMed ID: 7850771
An immunohistochemical study of protein kinase C distribution in fetal mouse vertebral column.
Bareggi R, Neri LM, Grill V, Cocco L, Martelli AM
Anat Embryol (Berl). 1994
PubMed ID: 7985811
A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.
Akimoto K, Mizuno K, Osada S, Hirai S, Tanuma S, Suzuki K, Ohno S
J Biol Chem. 1994
PubMed ID: 7513693
Towards high resolution maps of the mouse and human genomes--a facility for ordering markers to 0.1 cM resolution. European Backcross Collaborative Group.

Hum Mol Genet. 1994
PubMed ID: 8069308
Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report.
Gupta S, Aggarwal S, Kim C, Gollapudi S
Int J Immunopharmacol. 1994
PubMed ID: 8206685
PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning.
Abeliovich A, Paylor R, Chen C, Kim JJ, Wehner JM, Tonegawa S
Cell. 1993
PubMed ID: 8269510
Modified hippocampal long-term potentiation in PKC gamma-mutant mice.
Abeliovich A, Chen C, Goda Y, Silva AJ, Stevens CF, Tonegawa S
Cell. 1993
PubMed ID: 8269509
Mapping the Hrc gene to proximal mouse chromosome 7: delineation of a conserved linkage group with human 19q.
Brown SD, Chartier F, Johnson K, Cavanna JS
Genomics. 1993
PubMed ID: 8288260
Activation and substrate specificity of the human protein kinase C alpha and zeta isoenzymes.
Kochs G, Hummel R, Meyer D, Hug H, Marmé D, Sarre TF
Eur J Biochem. 1993
PubMed ID: 8375396
Characterization of a 7.5-kDa protein kinase C substrate (RC3 protein, neurogranin) from rat brain.
Huang KP, Huang FL, Chen HC
Arch Biochem Biophys. 1993
PubMed ID: 8080473
Isolation and sequence of a mouse brain cDNA coding for protein kinase C-gamma isozyme.
Bowers BJ, Parham CL, Sikela JM, Wehner JM
Gene. 1993
PubMed ID: 8428669
Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.
Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A
Genomics. 1993
PubMed ID: 8432525
Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.
Watson ML, Rao JK, Gilkeson GS, Ruiz P, Eicher EM, Pisetsky DS, Matsuzawa A, Rochelle JM, Seldin MF
J Exp Med. 1992
PubMed ID: 1460423
Rat gene mapping using PCR-analyzed microsatellites.
Serikawa T, Kuramoto T, Hilbert P, Mori M, Yamada J, Dubay CJ, Lindpainter K, Ganten D, Guénet JL, Lathrop GM
Genetics. 1992
PubMed ID: 1628813
Characterization of murine carcinoembryonic antigen gene family members.
Rudert F, Saunders AM, Rebstock S, Thompson JA, Zimmermann W
Mamm Genome. 1992
PubMed ID: 1638085
A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx.
Ruegg CL, Strand M
Cell Immunol. 1991
PubMed ID: 1832084
Mouse bcl-3: cDNA structure, mapping and stage-dependent expression in B lymphocytes.
Bhatia K, Huppi K, McKeithan T, Siwarski D, Mushinski JF, Magrath I
Oncogene. 1991
PubMed ID: 1923524
Phorbol diester-induced alterations in the expression of protein kinase C isozymes and their mRNAs. Analysis in wild-type and phorbol diester-resistant HL-60 cell clones.
McSwine-Kennick RL, McKeegan EM, Johnson MD, Morin MJ
J Biol Chem. 1991
PubMed ID: 1714454
Characterization of the 5'-flanking region of the rat protein kinase C gamma gene.
Chen KH, Widen SG, Wilson SH, Huang KP
J Biol Chem. 1990
PubMed ID: 2246272
A molecular genetic linkage map of mouse chromosome 7.
Saunders AM, Seldin MF
Genomics. 1990
PubMed ID: 1981054
Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41.
Ruegg CL, Strand M
J Immunol. 1990
PubMed ID: 2139676
Establishment of the mouse chromosome 7 region with homology to the myotonic dystrophy region of human chromosome 19q.
Cavanna JS, Greenfield AJ, Johnson KJ, Marks AR, Nadal-Ginard B, Brown SD
Genomics. 1990
PubMed ID: 1970795
The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway.
Chowdhury IH, Koyanagi Y, Kobayashi S, Hamamoto Y, Yoshiyama H, Yoshida T, Yamamoto N
Virology. 1990
PubMed ID: 1970444
Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C.
Jakobovits A, Rosenthal A, Capon DJ
EMBO J. 1990
PubMed ID: 2182321
The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q.
Saunders AM, Seldin MF
Genomics. 1990
PubMed ID: 2307474
Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a.
Wada H, Ohno S, Kubo K, Taya C, Tsuji S, Yonehara S, Suzuki K
Biochem Biophys Res Commun. 1989
PubMed ID: 2590242
Induction of tumor promotor-inducible genes in murine 3T3 cell lines and tetradecanoyl phorbol acetate-nonproliferative 3T3 variants can occur through protein kinase C-dependent and -independent pathways.
Lim RW, Varnum BC, O'Brien TG, Herschman HR
Mol Cell Biol. 1989
PubMed ID: 2471069
Nucleotide sequences of cDNAs for alpha and gamma subspecies of rat brain protein kinase C.
Ono Y, Fujii T, Igarashi K, Kikkawa U, Ogita K, Nishizuka Y
Nucleic Acids Res. 1988
PubMed ID: 3387228
Human immunodeficiency virus induces phosphorylation of its cell surface receptor.
Fields AP, Bednarik DP, Hess A, May WS
Nature. 1988
PubMed ID: 3259291
Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes.
Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ, Lingrel JB, Francke U
Genomics. 1988
PubMed ID: 2842249
Linkage relationships of the protein kinase C gamma gene which exclude it as a candidate for myotonic dystrophy.
Johnson KJ, Jones PJ, Spurr N, Nimmo E, Davies J, Creed H, Weiss M, Williamson R
Cytogenet Cell Genet. 1988
PubMed ID: 2460293
Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.
Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A
Science. 1986
PubMed ID: 3755548
Cloning and expression of multiple protein kinase C cDNAs.
Knopf JL, Lee MH, Sultzman LA, Kriz RW, Loomis CR, Hewick RM, Bell RM
Cell. 1986
PubMed ID: 3755379
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Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	5582	18752	24681
EnsEMBL Gene(s)	ENSG00000126583	ENSMUSG00000078816	ENSRNOG00000014688
Unigene	Hs.631564	Mm.7980	Rn.9747
Homologene	PRKCG	Prkcc	Prkcg
OMIM	176980	N/A	N/A
GeneCards	PRKCG	N/A	N/A
Beta Cell Genomics	DT.411273 DT.95351170	DT.111203025 DT.87068447	N/A
Reactome	P05129	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	5582	18752	24681

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
PRKCG	OCLN	HPRD	empirical	11502742
PRKCG	PDLIM5	HPRD	empirical	8940095
PRKCG	EXOC5	HPRD, MINT, IntAct	empirical	16713569
PRKCG	NOXA1	HPRD, MINT, IntAct	empirical	16713569
PRKCG	CHAT	HPRD	empirical	15381704
PRKCG	LDB3	MINT	empirical	10391924
PRKCG	ADRB2	BioGRID	empirical	10753752
PRKCG	ADRBK1	HPRD	empirical	11042191
PRKCG	DAB2	HPRD	empirical	10542228
PRKCG	DVL2	HPRD	empirical	12958364
PRKCG	EIF4E	HPRD	empirical	8662663
PRKCG	HABP4	HPRD	empirical	14699138
PRKCG	DDX58	BioGRID	empirical	22114345
PRKCG	GABRA1	HPRD, BioGRID	empirical	12091471
PRKCG	GABRA4	HPRD, BioGRID	empirical	12091471
PRKCG	GABRR1	BioGRID	empirical	12175859
PRKCG	GJA1	HPRD	empirical	10871288
PRKCG	GJA3	HPRD	empirical	15467523
PRKCG	GRIA4	HPRD, BioGRID	empirical	12471040
PRKCG	GRIN1	HPRD, IntAct	empirical	10862698 16635246
PRKCG	GRIN2B	HPRD, IntAct	empirical	12147342 8940188 11306676 16635246
PRKCG	GRIN2D	HPRD	empirical	10862698
PRKCG	GRM5	HPRD	empirical	15894802
PRKCG	GSK3A	HPRD	empirical	11035810 11884598 11749387 12054501
PRKCG	ANXA7	HPRD	empirical	11278415
PRKCG	IRS1	HPRD	empirical	15364919
PRKCG	NFE2L2	BioGRID	empirical	19920073
PRKCG	NRGN	HPRD	empirical	8080473
PRKCG	PA2G4	HPRD	empirical	11325528
PRKCG	PEBP1	HPRD	empirical	14654844 12551925
PRKCG	PARD6A	HPRD	empirical	14676191
PRKCG	CCHCR1	HPRD, MINT, IntAct	empirical	16713569
PRKCG	PRKCG	BioGRID	empirical	19920073
PRKCG	PARD3	HPRD	empirical	14676191
PRKCG	PTPN1	MINT	empirical	17092689
PRKCG	MARK4	HPRD	empirical	14676191
PRKCG	RGS2	HPRD, BioGRID	empirical	11063746
PRKCG	AFAP1	HPRD, BioGRID	empirical	12134071
PRKCG	SDC2	HPRD	empirical	9244383
PRKCG	SNCA	BioGRID	empirical	10407019
PRKCG	STXBP1	HPRD	empirical	8631738 12519779 12950453
PRKCG	TIAM1	HPRD, BioGRID	empirical	10212259
PRKCG	TOP2A	HPRD	empirical	7499337 12569090
PRKCG	UBC	BioGRID	empirical	20596523
PRKCG	VTN	HPRD	empirical	9030777
PRKCG	YWHAB	HPRD, IntAct	empirical	14676191 16635246
PRKCG	YWHAE	HPRD	empirical	15459208
PRKCG	YWHAG	HPRD, BioGRID	empirical	10433554
PRKCG	YWHAZ	IntAct	empirical	19562802
PRKCG	CASR	HPRD	empirical	9694886
PRKCG	PARD6B	HPRD	empirical	14676191
PRKCG	NUMB	HPRD	empirical	17203073
PRKCG	CD5	HPRD	empirical	11123317
PRKCG	PNMA1	HPRD	empirical	14676191
PRKCG	CYTH2	HPRD	empirical	10531036
PRKCG	PPP1R14A	HPRD	empirical	15003508
PRKCG	PICK1	HPRD, MINT, IntAct	empirical	16713569
PRKCG	CLOCK	MINT	empirical	17347670
PRKCG	CDC42	HPRD	empirical	14676191