PRKCB

Summary Top Help

Gene Description:

protein kinase C, beta

Synonyms:

PRKCB2, PRKCB, PRKCB1, PKCB, A130082F03Rik, Prkcb1, PKC-Beta, Pkcb, PKC-beta, Prkcb, Prkcb2

Orthologs:

Human PRKCB (protein-coding), Mouse Prkcb (protein-coding), Rat Prkcb (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1 Rat: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Not assigned	Mouse	chr7:117936155..152524553	34.59	508

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm10	Rat	chr1:178054386..201472944	23.42	321

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr16:23847300..24231932 (384.63 kb) View in Genome Browser

(Mouse) NCBIM37 - chr7:129432265..129777916 (345.65 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:181117512..181459856 (342.34 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PRKCB:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PRKCB:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 36

Biocarta: 39

Activation of PKC through G protein coupled receptor	Human	Mouse
Activation of Src by Protein-tyrosine phosphatase alpha	Human	Mouse
Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling	Human	Mouse
Apoptotic Signaling in Response to DNA Damage	Human	Mouse
Aspirin Blocks Signaling Pathway Involved in Platelet Activation	Human
Attenuation of GPCR Signaling	Human	Mouse
BCR Signaling Pathway	Human	Mouse
Bioactive Peptide Induced Signaling Pathway	Human	Mouse
Cadmium induces DNA synthesis and proliferation in macrophages	Human	Mouse
CBL mediated ligand-induced downregulation of EGF receptors	Human	Mouse
CCR3 signaling in Eosinophils	Human	Mouse
CXCR4 Signaling Pathway	Human	Mouse
Effects of calcineurin in Keratinocyte Differentiation	Human	Mouse
EGF Signaling Pathway	Human	Mouse
Fc Epsilon Receptor I Signaling in Mast Cells	Human	Mouse
g-Secretase mediated ErbB4 Signaling Pathway	Human	Mouse
Growth Hormone Signaling Pathway	Human	Mouse
Ion Channel and Phorbal Esters Signaling Pathway	Human	Mouse
Keratinocyte Differentiation	Human	Mouse
Links between Pyk2 and Map Kinases	Human	Mouse
Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)	Human
Nitric Oxide Signaling Pathway	Human	Mouse
Oxidative Stress Induced Gene Expression Via Nrf2	Human	Mouse
PDGF Signaling Pathway	Human	Mouse
Pertussis toxin-insensitive CCR5 Signaling in Macrophage	Human	Mouse
Phospholipase C d1 in phospholipid associated cell signaling	Human	Mouse
Phospholipase C Signaling Pathway	Human	Mouse
Phospholipids as signalling intermediaries	Human	Mouse
PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase	Human
Regulation of eIF4e and p70 S6 Kinase	Human	Mouse
Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy	Human	Mouse
Role of MEF2D in T-cell Apoptosis	Human	Mouse
Signaling Pathway from G-Protein Families	Human	Mouse
T Cell Receptor Signaling Pathway	Human	Mouse
Thrombin signaling and protease-activated receptors	Human	Mouse
TPO Signaling Pathway	Human	Mouse
Transcription factor CREB and its extracellular signals	Human	Mouse
Trka Receptor Signaling Pathway	Human	Mouse
VEGF, Hypoxia, and Angiogenesis	Human

Reactome: 14

NCI-Nature Pathway Interaction Database: 7

Gene Ontology: 36

Publications from PubMed Top Help

Type 1 Diabetes Publications: 9

Protein Kinase C Upregulates Intercellular Adhesion Molecule-1 and Leukocyte-Endothelium Interactions in Hyperglycemia via Activation of Endothelial Expressed Calpain.
Smolock AR, Mishra G, Eguchi K, Eguchi S, Scalia R
Arterioscler Thromb Vasc Biol. 2010
PubMed ID: 21071702
Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein Gα11.
Hoyer DP, Korkmaz Y, Grönke S, Addicks K, Wettschureck N, Offermanns S, Reuter H
Cardiovasc Diabetol. 2010
PubMed ID: 21190563
No support for association of protein kinase C, beta 1 (PRKCB1) gene promoter polymorphisms c.-1504C>T and c.-546C>G with diabetic nephropathy in Type 1 diabetes.
Pettigrew KA, McKnight AJ, Martin RJ, Patterson CC, Kilner J, Sadlier D, Maxwell AP, Savage DA, The Warren 3/UK GoKinD Study Group
Diabet Med. 2008
PubMed ID: 18937679
Identification of a functional protein kinase Cbeta promoter polymorphism in humans related to insulin resistance.
Osterhoff MA, Heuer S, Pfeiffer M, Tasic J, Kaiser S, Isken F, Spranger J, Weickert MO, Möhlig M, Pfeiffer AF
Mol Genet Metab. 2008
PubMed ID: 17950644
Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats.
Arikawa E, Ma RC, Isshiki K, Luptak I, He Z, Yasuda Y, Maeno Y, Patti ME, Weir GC, Harris RA, Zammit VA, Tian R, King GL
Diabetes. 2007
PubMed ID: 17363743
Identification of a common risk haplotype for diabetic nephropathy at the protein kinase C-beta1 (PRKCB1) gene locus.
Araki S, Ng DP, Krolewski B, Wyrwicz L, Rogus JJ, Canani L, Makita Y, Haneda M, Warram JH, Krolewski AS
J Am Soc Nephrol. 2003
PubMed ID: 12874455
Protein kinase C beta2-dependent phosphorylation of core 2 GlcNAc-T promotes leukocyte-endothelial cell adhesion: a mechanism underlying capillary occlusion in diabetic retinopathy.
Chibber R, Ben-Mahmud BM, Mann GE, Zhang JJ, Kohner EM
Diabetes. 2003
PubMed ID: 12765965
Dynamics of glucose-induced membrane recruitment of protein kinase C beta II in living pancreatic islet beta-cells.
Pinton P, Tsuboi T, Ainscow EK, Pozzan T, Rizzuto R, Rutter GA
J Biol Chem. 2002
PubMed ID: 12149258
Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells.
Kaneto H, Suzuma K, Sharma A, Bonner-Weir S, King GL, Weir GC
J Biol Chem. 2002
PubMed ID: 11714718

Publications: 482

Conventional protein kinase C-α (PKC-α) and PKC-β negatively regulate RIG-I antiviral signal transduction.
Maharaj NP, Wies E, Stoll A, Gack MU
J Virol. 2012
PubMed ID: 22114345
Specific protein kinase C isoforms are required for rod photoreceptor differentiation.
Pinzon-Guzman C, Zhang SS, Barnstable CJ
J Neurosci. 2011
PubMed ID: 22171059
Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-beta, and c-Jun N-terminal kinase kinase in human endothelial cells.
Shi Y, Cosentino F, Camici GG, Akhmedov A, Vanhoutte PM, Tanner FC, Lüscher TF
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21817106
Protein kinase C β inhibition ameliorates experimental mesangial proliferative glomerulonephritis.
Tokuyama H, Kim S, Zhang Y, Langham RG, Cox AJ, Gow RM, Kelly DJ, Gilbert RE
Nephrology (Carlton). 2011
PubMed ID: 21575103
Epithelial-mesenchymal transdifferentiation of renal tubular epithelial cells induced by urinary proteins requires the activation of PKC-α and βI isozymes.
Tang R, Yang C, Tao JL, You YK, An N, Li SM, Wu HL, Liu HF
Cell Biol Int. 2011
PubMed ID: 21323641
Apurinic/apyrimidinic endonuclease 1 inhibits protein kinase C-mediated p66shc phosphorylation and vasoconstriction.
Lee SK, Chung JI, Park MS, Joo HK, Lee EJ, Cho EJ, Park JB, Ryoo S, Irani K, Jeon BH
Cardiovasc Res. 2011
PubMed ID: 21467074
PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses.
Palaniyandi SS, Ferreira JC, Brum PC, Mochly-Rosen D
J Cell Mol Med. 2011
PubMed ID: 20874717
Disruption of the murine protein kinase Cbeta gene promotes gallstone formation and alters biliary lipid and hepatic cholesterol metabolism.
Huang W, Bansode RR, Xie Y, Rowland L, Mehta M, Davidson NO, Mehta KD
J Biol Chem. 2011
PubMed ID: 21550971
Effect of perinatal thyroid hormone deficiency on expression of rat hippocampal conventional protein kinase C isozymes.
Zhang HM, Lin N, Dong Y, Su Q, Luo M
Mol Cell Biochem. 2011
PubMed ID: 21424759
Unravelling the different functions of protein kinase C isoforms in platelets.
Heemskerk JW, Harper MT, Cosemans JM, Poole AW
FEBS Lett. 2011
PubMed ID: 21596041
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth.
Miluzio A, Beugnet A, Grosso S, Brina D, Mancino M, Campaner S, Amati B, de Marco A, Biffo S
Cancer Cell. 2011
PubMed ID: 21665150
Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held.
Fioravante D, Chu Y, Myoga MH, Leitges M, Regehr WG
Neuron. 2011
PubMed ID: 21658591
Priming of eosinophils by GM-CSF is mediated by protein kinase CbetaII-phosphorylated L-plastin.
Pazdrak K, Young TW, Straub C, Stafford S, Kurosky A
J Immunol. 2011
PubMed ID: 21525390
Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity.
Mima A, Ohshiro Y, Kitada M, Matsumoto M, Geraldes P, Li C, Li Q, White GS, Cahill C, Rask-Madsen C, King GL
Kidney Int. 2011
PubMed ID: 21228767
Follow-up study identifies two novel susceptibility loci PRKCB and 8p11.21 for systemic lupus erythematosus.
Sheng YJ, Gao JP, Li J, Han JW, Xu Q, Hu WL, Pan TM, Cheng YL, Yu ZY, Ni C, Yao S, He CF, Liu YS, Li Y, Ge HM, Xiao FL, Sun LD, Yang S, Zhang XJ
Rheumatology (Oxford). 2011
PubMed ID: 21134959
Crystal structure and allosteric activation of protein kinase C βII.
Leonard TA, Różycki B, Saidi LF, Hummer G, Hurley JH
Cell. 2011
PubMed ID: 21215369
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
Protein kinase C βII and δ/θ play critical roles in bone morphogenic protein-4-stimulated osteoblastic differentiation of MC3T3-E1 cells.
Park KH, Han DI, Rhee YH, Jeong SJ, Kim SH, Park YG
Biochem Biophys Res Commun. 2010
PubMed ID: 20971075
Phosphoproteomics profiling suggests a role for nuclear βΙPKC in transcription processes of undifferentiated murine embryonic stem cells.
Costa-Junior HM, Garavello NM, Duarte ML, Berti DA, Glaser T, de Andrade A, Labate CA, Ferreira AT, Perales JE, Xavier-Neto J, Krieger JE, Schechtman D
J Proteome Res. 2010
PubMed ID: 20936827
eEF1A phosphorylation in the nucleus of insulin-stimulated C2C12 myoblasts: Ser⁵³ is a novel substrate for protein kinase C βI.
Piazzi M, Bavelloni A, Faenza I, Blalock W, Urbani A, D'Aguanno S, Fiume R, Ramazzotti G, Maraldi NM, Cocco L
Mol Cell Proteomics. 2010
PubMed ID: 20923971
Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting.
Joller N, Weber SS, Müller AJ, Spörri R, Selchow P, Sander P, Hilbi H, Oxenius A
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21048081
High-molecular weight hyaluronan reduced renal PKC activation in genetically diabetic mice.
Campo GM, Avenoso A, Micali A, Nastasi G, Squadrito F, Altavilla D, Bitto A, Polito F, Rinaldi MG, Calatroni A, D'Ascola A, Campo S
Biochim Biophys Acta. 2010
PubMed ID: 20713153
Triggering Ras signalling by intracellular Francisella tularensis through recruitment of PKCα and βI to the SOS2/GrB2 complex is essential for bacterial proliferation in the cytosol.
Al-Khodor S, Abu Kwaik Y
Cell Microbiol. 2010
PubMed ID: 20618341
Differential subcellular expression of protein kinase C betaII in breast cancer: correlation with breast cancer subtypes.
Gökmen-Polar Y, Mehta R, Tuzmen S, Mousses S, Thorat MA, Sanders KL, Turbin D, Leung S, Huntsman DG, Sledge GW, Badve S
Breast Cancer Res Treat. 2010
PubMed ID: 20099025
The PKCbeta/HuR/VEGF pathway in diabetic retinopathy.
Amadio M, Bucolo C, Leggio GM, Drago F, Govoni S, Pascale A
Biochem Pharmacol. 2010
PubMed ID: 20599775
Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens.
Almeida M, Han L, Ambrogini E, Bartell SM, Manolagas SC
Mol Endocrinol. 2010
PubMed ID: 20685851
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Reduction of PKCbetaII activity in smooth muscle cells attenuates acute arterial injury.
Huang C, Chang JS, Xu Y, Li Q, Zou YS, Yan SF
Atherosclerosis. 2010
PubMed ID: 20594553
Expression of protein kinase C family in human hepatocellular carcinoma.
Lu HC, Chou FP, Yeh KT, Chang YS, Hsu NC, Chang JG
Pathol Oncol Res. 2010
PubMed ID: 19949911
Genetic variants of the protein kinase C-beta 1 gene and development of end-stage renal disease in patients with type 2 diabetes.
Ma RC, Tam CH, Wang Y, Luk AO, Hu C, Yang X, Lam V, Chan AW, Ho JS, Chow CC, Tong PC, Jia W, Ng MC, So WY, Chan JC
JAMA. 2010
PubMed ID: 20736472
Protein kinase C-induced phosphorylation of Orai1 regulates the intracellular Ca2+ level via the store-operated Ca2+ channel.
Kawasaki T, Ueyama T, Lange I, Feske S, Saito N
J Biol Chem. 2010
PubMed ID: 20534587
Specific inhibition of protein kinase Cbeta expression by antisense RNA affects the activation of Jurkat T lymphoma cells.
Cervino MC, Lopez-Lago MA, Vinuela JE, Barja P
J Biol Regul Homeost Agents. 2010
PubMed ID: 20846475
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.
Kasperaviciūte D, Catarino CB, Heinzen EL, Depondt C, Cavalleri GL, Caboclo LO, Tate SK, Jamnadas-Khoda J, Chinthapalli K, Clayton LM, Shianna KV, Radtke RA, Mikati MA, Gallentine WB, Husain AM, Alhusaini S, Leppert D, Middleton LT, Gibson RA, Johnson MR, Matthews PM, Hosford D, Heuser K, Amos L, Ortega M, Zumsteg D, Wieser HG, Steinhoff BJ, Krämer G, Hansen J, Dorn T, Kantanen AM, Gjerstad L, Peuralinna T, Hernandez DG, Eriksson KJ, Kälviäinen RK, Doherty CP, Wood NW, Pandolfo M, Duncan JS, Sander JW, Delanty N, Goldstein DB, Sisodiya SM
Brain. 2010
PubMed ID: 20522523
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain.
Rigor RR, Hawkins BT, Miller DS
J Cereb Blood Flow Metab. 2010
PubMed ID: 20197783
Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin.
Yamamoto T, Watanabe K, Inoue N, Nakagawa Y, Ishigaki N, Matsuzaka T, Takeuchi Y, Kobayashi K, Yatoh S, Takahashi A, Suzuki H, Yahagi N, Gotoda T, Yamada N, Shimano H
J Lipid Res. 2010
PubMed ID: 20179320
Vascular endothelial growth factor stimulates protein kinase CbetaII expression in chronic lymphocytic leukemia cells.
Abrams ST, Brown BR, Zuzel M, Slupsky JR
Blood. 2010
PubMed ID: 20164467
Signaling pathways involved in postconditioning-induced cardioprotection of human myocardium, in vitro.
Lemoine S, Puddu PE, Durand C, Lepage O, Babatasi G, Ivascau C, Massetti M, Gérard JL, Hanouz JL
Exp Biol Med (Maywood). 2010
PubMed ID: 20511681
Linkage and candidate gene studies of autism spectrum disorders in European populations.
Holt R, Barnby G, Maestrini E, Bacchelli E, Brocklebank D, Sousa I, Mulder EJ, Kantojärvi K, Järvelä I, Klauck SM, Poustka F, Bailey AJ, Monaco AP
Eur J Hum Genet. 2010
PubMed ID: 20442744
Protein kinase C-beta gene variants, pathway activation, and enzastaurin activity in lung cancer.
Lee SH, Chen T, Zhou J, Hofmann J, Bepler G
Clin Lung Cancer. 2010
PubMed ID: 20439192
Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability.
Deng PY, Xiao Z, Jha A, Ramonet D, Matsui T, Leitges M, Shin HS, Porter JE, Geiger JD, Lei S
J Neurosci. 2010
PubMed ID: 20392936
Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain.
Hennige AM, Heni M, Machann J, Staiger H, Sartorius T, Hoene M, Lehmann R, Weigert C, Peter A, Bornemann A, Kroeber S, Pujol A, Franckhauser S, Bosch F, Schick F, Lammers R, Häring HU
J Cell Mol Med. 2010
PubMed ID: 20569275
Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.
Metzger E, Imhof A, Patel D, Kahl P, Hoffmeyer K, Friedrichs N, Müller JM, Greschik H, Kirfel J, Ji S, Kunowska N, Beisenherz-Huss C, Günther T, Buettner R, Schüle R
Nature. 2010
PubMed ID: 20228790
Functional alterations in protein kinase C beta II expression in melanoma.
Voris JP, Sitailo LA, Rahn HR, Defnet A, Gerds AT, Sprague R, Yadav V, Caroline Le Poole I, Denning MF
Pigment Cell Melanoma Res. 2010
PubMed ID: 20015121
Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.
Roberts KE, Kawut SM, Krowka MJ, Brown RS, Trotter JF, Shah V, Peter I, Tighiouart H, Mitra N, Handorf E, Knowles JA, Zacks S, Fallon MB, Pulmonary Vascular Complications of Liver Disease Study Group
Gastroenterology. 2010
PubMed ID: 20346360
Ca2+ influx and protein scaffolding via TRPC3 sustain PKCbeta and ERK activation in B cells.
Numaga T, Nishida M, Kiyonaka S, Kato K, Katano M, Mori E, Kurosaki T, Inoue R, Hikida M, Putney JW, Mori Y
J Cell Sci. 2010
PubMed ID: 20179100
Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms.
Massip L, Garand C, Labbé A, Perreault E, Turaga RV, Bohr VA, Lebel M
Oncogene. 2010
PubMed ID: 19966859
Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications.
Tabit CE, Chung WB, Hamburg NM, Vita JA
Rev Endocr Metab Disord. 2010
PubMed ID: 20186491
Protein kinase C beta (PRKCB1) and pigment epithelium derived factor (PEDF) gene polymorphisms and diabetic retinopathy in a south Indian cohort.
Uthra S, Raman R, Mukesh BN, Rajkumar SA, Kumari PR, Lakshmipathy P, Gnanamoorthy P, Sharma T, McCarty CA, Kumaramanickavel G
Ophthalmic Genet. 2010
PubMed ID: 20141354
Protein kinase C: poised to signal.
Newton AC
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 19934406
Puerarin attenuates high-glucose-and diabetes-induced vascular smooth muscle cell proliferation by blocking PKCbeta2/Rac1-dependent signaling.
Zhu LH, Wang L, Wang D, Jiang H, Tang QZ, Yan L, Bian ZY, Wang XA, Li H
Free Radic Biol Med. 2010
PubMed ID: 19854265
Role of PKCbetaII and PKCdelta in blood-brain barrier permeability during aglycemic hypoxia.
Kim YA, Park SL, Kim MY, Lee SH, Baik EJ, Moon CH, Jung YS
Neurosci Lett. 2010
PubMed ID: 19900507
Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy.
Meng XW, Heldebrant MP, Flatten KS, Loegering DA, Dai H, Schneider PA, Gomez TS, Peterson KL, Trushin SA, Hess AD, Smith BD, Karp JE, Billadeau DD, Kaufmann SH
J Biol Chem. 2010
PubMed ID: 19887445
Protein kinase C regulates rod photoreceptor differentiation through modulation of STAT3 signaling.
Pinzon-Guzman C, Shaomin Zhang S, Barnstable CJ
Adv Exp Med Biol. 2010
PubMed ID: 20237998
Expanding the substantial interactome of NEMO using protein microarrays.
Fenner BJ, Scannell M, Prehn JH
PLoS One. 2010
PubMed ID: 20098747
Recruitment of PKC-betaII to lipid rafts mediates apoptosis-resistance in chronic lymphocytic leukemia expressing ZAP-70.
zum Büschenfelde CM, Wagner M, Lutzny G, Oelsner M, Feuerstacke Y, Decker T, Bogner C, Peschel C, Ringshausen I
Leukemia. 2010
PubMed ID: 19907441
Conventional protein kinase C plays a critical role in negative regulation of CD98-induced homotypic aggregation.
Cho JY, Katz DR, Skubitz KM, Chain BM
Tissue Antigens. 2010
PubMed ID: 19895572
Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance.
Niture SK, Jain AK, Jaiswal AK
J Cell Sci. 2009
PubMed ID: 19920073
Cell invasion of Yersinia pseudotuberculosis by invasin and YadA requires protein kinase C, phospholipase C-gamma1 and Akt kinase.
Uliczka F, Kornprobst T, Eitel J, Schneider D, Dersch P
Cell Microbiol. 2009
PubMed ID: 19681907
Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model.
Grossoni VC, Todaro LB, Kazanietz MG, de Kier Joffé ED, Urtreger AJ
Breast Cancer Res Treat. 2009
PubMed ID: 19132529
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Developmentally spliced PKCbetaII provides a possible link between mTORC2 and Akt kinase to regulate 3T3-L1 adipocyte insulin-stimulated glucose transport.
Kleiman E, Carter G, Ghansah T, Patel NA, Cooper DR
Biochem Biophys Res Commun. 2009
PubMed ID: 19686698
Swiprosin-1 is expressed in mast cells and up-regulated through the protein kinase C beta I/eta pathway.
Thylur RP, Kim YD, Kwon MS, Oh HM, Kwon HK, Kim SH, Im SH, Chun JS, Park ZY, Jun CD
J Cell Biochem. 2009
PubMed ID: 19693767
Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats.
Nagareddy PR, Soliman H, Lin G, Rajput PS, Kumar U, McNeill JH, MacLeod KM
Diabetes. 2009
PubMed ID: 19587355
Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls.
Shelton RC, Hal Manier D, Lewis DA
Int J Neuropsychopharmacol. 2009
PubMed ID: 19573263
EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells.
Wu D, Peng F, Zhang B, Ingram AJ, Kelly DJ, Gilbert RE, Gao B, Kumar S, Krepinsky JC
Am J Physiol Renal Physiol. 2009
PubMed ID: 19605547
Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.
Liu Q, Chen X, Macdonnell SM, Kranias EG, Lorenz JN, Leitges M, Houser SR, Molkentin JD
Circ Res. 2009
PubMed ID: 19556521
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression.
Lintas C, Sacco R, Garbett K, Mirnics K, Militerni R, Bravaccio C, Curatolo P, Manzi B, Schneider C, Melmed R, Elia M, Pascucci T, Puglisi-Allegra S, Reichelt KL, Persico AM
Mol Psychiatry. 2009
PubMed ID: 18317465
Steel factor enhances supraoptimal antigen-induced IL-6 production from mast cells via activation of protein kinase C-beta.
Fehrenbach K, Lessmann E, Zorn CN, Kuhny M, Grochowy G, Krystal G, Leitges M, Huber M
J Immunol. 2009
PubMed ID: 19494314
Protein kinase C-beta II (PKC-beta II) expression in patients with colorectal cancer.
Spindler KL, Lindebjerg J, Lahn M, Kjaer-Frifeldt S, Jakobsen A
Int J Colorectal Dis. 2009
PubMed ID: 19277684
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Loss of protein kinase Cbeta function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance.
Huang W, Bansode R, Mehta M, Mehta KD
Hepatology. 2009
PubMed ID: 19296465
Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCbetaII messenger ribonucleic acid.
Jiang K, Patel NA, Watson JE, Apostolatos H, Kleiman E, Hanson O, Hagiwara M, Cooper DR
Endocrinology. 2009
PubMed ID: 19116344
[Antagonism of LY333531 on high glucose induced permeability upregulation of cardiac microvascular endothelial cells]
Yin ZY, Wei LP, Hao YY, Zhang RQ, Li CY, Wang HC
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009
PubMed ID: 19351495
Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis.
Harja E, Chang JS, Lu Y, Leitges M, Zou YS, Schmidt AM, Yan SF
FASEB J. 2009
PubMed ID: 19036858
PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia.
Holler C, Piñón JD, Denk U, Heyder C, Hofbauer S, Greil R, Egle A
Blood. 2009
PubMed ID: 19168795
Role of protein kinase C beta2 activation in TNF-alpha-induced human vascular endothelial cell apoptosis.
Wang F, Liu HM, Irwin MG, Xia ZY, Huang Z, Ouyang J, Xia Z
Can J Physiol Pharmacol. 2009
PubMed ID: 19295663
Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function.
Rigor DL, Bodyak N, Bae S, Choi JH, Zhang L, Ter-Ovanesyan D, He Z, McMullen JR, Shioi T, Izumo S, King GL, Kang PM
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19122165
The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail.
Gould CM, Kannan N, Taylor SS, Newton AC
J Biol Chem. 2009
PubMed ID: 19091746
Protein kinase Cbeta is an effective target for chemoprevention of colon cancer.
Fields AP, Calcagno SR, Krishna M, Rak S, Leitges M, Murray NR
Cancer Res. 2009
PubMed ID: 19221092
Protein kinase C isoenzymes differentially regulate the differentiation-dependent expression of adhesion molecules in human epidermal keratinocytes.
Szegedi A, Páyer E, Czifra G, Tóth BI, Schmidt E, Kovács L, Blumberg PM, Bíró T
Exp Dermatol. 2009
PubMed ID: 18637128
Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression.
Murray NR, Weems J, Braun U, Leitges M, Fields AP
Cancer Res. 2009
PubMed ID: 19147581
Role of PKCbeta in hepatocellular carcinoma cells migration and invasion in vitro: a potential therapeutic target.
Guo K, Li Y, Kang X, Sun L, Cui J, Gao D, Liu Y
Clin Exp Metastasis. 2009
PubMed ID: 19112601
Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts.
Armstrong S, Pereverzev A, Dixon SJ, Sims SM
J Cell Sci. 2009
PubMed ID: 19066285
The ability of Listeria monocytogenes PI-PLC to facilitate escape from the macrophage phagosome is dependent on host PKCbeta.
Poussin MA, Leitges M, Goldfine H
Microb Pathog. 2009
PubMed ID: 18996181
Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells.
Corsini E, Racchi M, Lucchi L, Donetti E, Bedoni M, Viviani B, Galli CL, Marinovich M
Br J Dermatol. 2009
PubMed ID: 18945317
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
Distinct roles of protein kinase C isoforms in myogenic constriction of rat posterior cerebral arteries.
Kashihara T, Nakayama K, Ishikawa T
J Pharmacol Sci. 2008
PubMed ID: 19057126
mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice.
Liu JX, Tang YC, Liu Y, Tang FR
Epilepsy Res. 2008
PubMed ID: 18774262
Inhibition of protein kinase Cbeta prevents foam cell formation by reducing scavenger receptor A expression in human macrophages.
Osto E, Kouroedov A, Mocharla P, Akhmedov A, Besler C, Rohrer L, von Eckardstein A, Iliceto S, Volpe M, Lüscher TF, Cosentino F
Circulation. 2008
PubMed ID: 18981301
Eukaryotic ribosomes host PKC activity.
Grosso S, Volta V, Vietri M, Gorrini C, Marchisio PC, Biffo S
Biochem Biophys Res Commun. 2008
PubMed ID: 18768137
PKCbetaII modulates translation independently from mTOR and through RACK1.
Grosso S, Volta V, Sala LA, Vietri M, Marchisio PC, Ron D, Biffo S
Biochem J. 2008
PubMed ID: 18557705
PKCbetaII augments NF-kappaB-dependent transcription at the CCL11 promoter via p300/CBP-associated factor recruitment and histone H4 acetylation.
Clarke DL, Sutcliffe A, Deacon K, Bradbury D, Corbett L, Knox AJ
J Immunol. 2008
PubMed ID: 18714023
Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis.
Kim J, Choi YL, Vallentin A, Hunrichs BS, Hellerstein MK, Peehl DM, Mochly-Rosen D
Cancer Res. 2008
PubMed ID: 18701509
Apolipoprotein CIII links hyperlipidemia with vascular endothelial cell dysfunction.
Kawakami A, Osaka M, Tani M, Azuma H, Sacks FM, Shimokado K, Yoshida M
Circulation. 2008
PubMed ID: 18663085
Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation.
Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T
Nat Neurosci. 2008
PubMed ID: 18641643
Counter regulatory effects of PKCbetaII and PKCdelta on coronary endothelial permeability.
Gaudreault N, Perrin RM, Guo M, Clanton CP, Wu MH, Yuan SY
Arterioscler Thromb Vasc Biol. 2008
PubMed ID: 18497307
PKC delta in preeclamptic placentas promotes Bax dissociation from 14-3-3 zeta through 14-3-3 zeta phosphorylation.
Park JK, Kang MY, Kim YH, Jo HC, Shin JK, Choi WJ, Lee SA, Lee JH, Choi WS, Paik WY
Placenta. 2008
PubMed ID: 18472156
Two conventional protein kinase C isoforms, alpha and beta I, are involved in the ATP-induced activation of volume-regulated anion channel and glutamate release in cultured astrocytes.
Rudkouskaya A, Chernoguz A, Haskew-Layton RE, Mongin AA
J Neurochem. 2008
PubMed ID: 18315563
Differential modulation of unapposed connexin 43 hemichannel electrical conductance by protein kinase C isoforms.
Hawat G, Baroudi G
Pflugers Arch. 2008
PubMed ID: 18172602
Protein kinase CbetaI interacts with the beta1-adrenergic signaling pathway to attenuate lipolysis in rat adipocytes.
Nakamura J
Biochim Biophys Acta. 2008
PubMed ID: 18440322
Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products.
Chang JS, Wendt T, Qu W, Kong L, Zou YS, Schmidt AM, Yan SF
Circ Res. 2008
PubMed ID: 18323529
Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta.
Tatematsu K, Yoshimoto N, Okajima T, Tanizawa K, Kuroda S
J Biol Chem. 2008
PubMed ID: 18303026
Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism.
Seth A, Yan F, Polk DB, Rao RK
Am J Physiol Gastrointest Liver Physiol. 2008
PubMed ID: 18292183
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Increased renal gene transcription of protein kinase C-beta in human diabetic nephropathy: relationship to long-term glycaemic control.
Langham RG, Kelly DJ, Gow RM, Zhang Y, Cox AJ, Qi W, Thai K, Pollock CA, Christensen PK, Parving HH, Gilbert RE
Diabetologia. 2008
PubMed ID: 18278479
PKCbeta modulates ischemia-reperfusion injury in the heart.
Kong L, Andrassy M, Chang JS, Huang C, Asai T, Szabolcs MJ, Homma S, Liu R, Zou YS, Leitges M, Yan SD, Ramasamy R, Schmidt AM, Yan SF
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 18245560
Role of protein kinase C in selective inhibition of mouse retinal neurites during contacts with chondroitin sulfates.
Lam JS, Wang L, Lin L, Chan SO
Neurosci Lett. 2008
PubMed ID: 18313852
The phosphatase PHLPP controls the cellular levels of protein kinase C.
Gao T, Brognard J, Newton AC
J Biol Chem. 2008
PubMed ID: 18162466
Involvement of protein kinase C beta-extracellular signal-regulating kinase 1/2/p38 mitogen-activated protein kinase-heat shock protein 27 activation in hepatocellular carcinoma cell motility and invasion.
Guo K, Liu Y, Zhou H, Dai Z, Zhang J, Sun R, Chen J, Sun Q, Lu W, Kang X, Chen P
Cancer Sci. 2008
PubMed ID: 18167130
S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells.
Oliva JL, Caino MC, Senderowicz AM, Kazanietz MG
J Biol Chem. 2008
PubMed ID: 18162471
Role of phospholipase Cgamma-induced activation of protein kinase Cepsilon (PKCepsilon) and PKCbetaI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers.
Suzuki T, Seth A, Rao R
J Biol Chem. 2008
PubMed ID: 17991733
Phosphoproteome of resting human platelets.
Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schütz C, Walter U, Gambaryan S, Sickmann A
J Proteome Res. 2008
PubMed ID: 18088087
Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta.
McNally AK, Macewan SR, Anderson JM
Exp Mol Pathol. 2008
PubMed ID: 18067888
The context of HLA-DR/CD18 complex in the plasma membrane governs HLA-DR-derived signals in activated monocytes.
Doisne JM, Castaigne JG, Deruyffelaere C, Dieu-Nosjean MC, Chamot C, Alcaide-Loridan C, Charron D, Al-Daccak R
Mol Immunol. 2008
PubMed ID: 17719638
Protein kinase C deficiency increases fatty acid oxidation and reduces fat storage.
Bansode RR, Huang W, Roy SK, Mehta M, Mehta KD
J Biol Chem. 2008
PubMed ID: 17962198
Protein kinase C beta overexpression induces fibrotic effects in human proximal tubular epithelial cells.
Slattery C, Ryan MP, McMorrow T
Int J Biochem Cell Biol. 2008
PubMed ID: 18440851
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
Ballif BA, Carey GR, Sunyaev SR, Gygi SP
J Proteome Res. 2008
PubMed ID: 18034455
Protein kinase C-betaII represses hepatocyte growth factor-induced invasion by preventing the association of adapter protein Gab1 and phosphatidylinositol 3-kinase in melanoma cells.
Oka M, Kikkawa U, Nishigori C
J Invest Dermatol. 2008
PubMed ID: 17625596
The PKC pathway and in particular its beta1 isoform is clearly involved in meiotic arrest maintenance but poorly in FSH-induced meiosis resumption of the mouse cumulus cell enclosed oocyte.
Denys A, Avazeri N, Lefèvre B
Mol Reprod Dev. 2007
PubMed ID: 17474092
Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase.
Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton AC
J Biol Chem. 2007
PubMed ID: 17893151
Identification of fasting-induced genes in the rat hypothalamus: relationship with neuroprotection.
Chiba T, Fujita S, Kubota H, Inoue D, Mizuno A, Komatsu T, Yamaza H, Higami Y, Shimokawa I
Ann N Y Acad Sci. 2007
PubMed ID: 18056970
Differential expression of PKC beta II in the rat organ of Corti.
Ladrech S, Wang J, Boukhaddaoui H, Puel JL, Eybalin M, Lenoir M
Eur J Neurosci. 2007
PubMed ID: 18001287
Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN.
Fridberg M, Servin A, Anagnostaki L, Linderoth J, Berglund M, Söderberg O, Enblad G, Rosén A, Mustelin T, Jerkeman M, Persson JL, Wingren AG
Leuk Lymphoma. 2007
PubMed ID: 17926183
Reactive oxygen species, PKC-beta1, and PKC-zeta mediate high-glucose-induced vascular endothelial growth factor expression in mesangial cells.
Xia L, Wang H, Munk S, Frecker H, Goldberg HJ, Fantus IG, Whiteside CI
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17711990
Gender difference in rat aorta vasodilation after acute exposure to high glucose: involvement of protein kinase C beta and superoxide but not of Rho kinase.
Goel A, Zhang Y, Anderson L, Rahimian R
Cardiovasc Res. 2007
PubMed ID: 17678882
Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation.
Kuyumcu-Martinez NM, Wang GS, Cooper TA
Mol Cell. 2007
PubMed ID: 17936705
GLUT2 protein at the rat proximal tubule brush border membrane correlates with protein kinase C (PKC)-betal and plasma glucose concentration.
Goestemeyer AK, Marks J, Srai SK, Debnam ES, Unwin RJ
Diabetologia. 2007
PubMed ID: 17694297
Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.
Holmes K, Roberts OL, Thomas AM, Cross MJ
Cell Signal. 2007
PubMed ID: 17658244
Parathyroid hormone stimulates the endothelial nitric oxide synthase through protein kinase A and C pathways.
Rashid G, Bernheim J, Green J, Benchetrit S
Nephrol Dial Transplant. 2007
PubMed ID: 17545677
The essentiality of PKCalpha and PKCbetaI translocation for CD14+monocyte differentiation towards macrophages and dendritic cells, respectively.
Lin YF, Lee HM, Leu SJ, Tsai YH
J Cell Biochem. 2007
PubMed ID: 17455194
Differential protein kinase C isoform abundance in ascending aortic aneurysms from patients with bicuspid versus tricuspid aortic valves.
Jones JA, Stroud RE, Kaplan BS, Leone AM, Bavaria JE, Gorman JH, Gorman RC, Ikonomidis JS
Circulation. 2007
PubMed ID: 17846295
Dkk3-Cre BAC transgenic mouse line: a tool for highly efficient gene deletion in retinal progenitor cells.
Sato S, Inoue T, Terada K, Matsuo I, Aizawa S, Tano Y, Fujikado T, Furukawa T
Genesis. 2007
PubMed ID: 17661397
Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn.
Guo B, Blair D, Chiles TC, Lowell CA, Rothstein TL
J Immunol. 2007
PubMed ID: 17404251
Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption.
Morgan EL, Mace OJ, Affleck J, Kellett GL
J Physiol. 2007
PubMed ID: 17272350
Regulation of insulin receptor function.
Youngren JF
Cell Mol Life Sci. 2007
PubMed ID: 17347799
Human biliverdin reductase, a previously unknown activator of protein kinase C betaII.
Maines MD, Miralem T, Lerner-Marmarosh N, Shen J, Gibbs PE
J Biol Chem. 2007
PubMed ID: 17227757
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats.
Xia Z, Kuo KH, Nagareddy PR, Wang F, Guo Z, Guo T, Jiang J, McNeill JH
Cardiovasc Res. 2007
PubMed ID: 17250813
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H
Mol Cell Proteomics. 2007
PubMed ID: 17192257
Role of atypical protein kinase C isozymes and NF-kappaB in IL-1beta-induced expression of cyclooxygenase-2 in human myometrial smooth muscle cells.
Duggan SV, Lindstrom T, Iglesias T, Bennett PR, Mann GE, Bartlett SR
J Cell Physiol. 2007
PubMed ID: 17133356
Translocation of PKC-betaII is mediated via RACK-1 in the neuronal cells following dioxin exposure.
Lee HG, Kim SY, Choi EJ, Park KY, Yang JH
Neurotoxicology. 2007
PubMed ID: 16797713
Hemispheric differences in protein kinase C betaII levels in the rat amygdala: baseline asymmetry and lateralized changes associated with cue and context in a classical fear conditioning paradigm.
Orman R, Stewart M
Neuroscience. 2007
PubMed ID: 17118565
Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc.
Pinton P, Rimessi A, Marchi S, Orsini F, Migliaccio E, Giorgio M, Contursi C, Minucci S, Mantovani F, Wieckowski MR, Del Sal G, Pelicci PG, Rizzuto R
Science. 2007
PubMed ID: 17272725
Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model.
Meier M, Park JK, Overheu D, Kirsch T, Lindschau C, Gueler F, Leitges M, Menne J, Haller H
Diabetes. 2007
PubMed ID: 17259378
Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects.
Ghanim H, Aljada A, Daoud N, Deopurkar R, Chaudhuri A, Dandona P
Diabetologia. 2007
PubMed ID: 17180352
Protein kinase C-beta 1 gene variants are not associated with autism in the Irish population.
Yang MS, Cochrane L, Conroy J, Hawi Z, Fitzgerald M, Gallagher L, Gill M
Psychiatr Genet. 2007
PubMed ID: 17167344
Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM
Mol Cell Proteomics. 2007
PubMed ID: 17114649
B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CbetaII.
Abrams ST, Lakum T, Lin K, Jones GM, Treweeke AT, Farahani M, Hughes M, Zuzel M, Slupsky JR
Blood. 2007
PubMed ID: 17003377
aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb.
Smith CA, Lau KM, Rahmani Z, Dho SE, Brothers G, She YM, Berry DM, Bonneil E, Thibault P, Schweisguth F, Le Borgne R, McGlade CJ
EMBO J. 2007
PubMed ID: 17203073
RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function.
Vallentin A, Mochly-Rosen D
J Biol Chem. 2007
PubMed ID: 17121852
Protein Kinase C- alpha/betaII, delta, and zeta/lambda involvement in ethanol-induced MAPK expression in vascular smooth muscle cells.
Johnson AL, Goode GD, Mtshali C, Myles EL, Washington B
Cell Mol Biol (Noisy-le-grand). 2007
PubMed ID: 17531159
PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.
Yoshida Y, Han B, Mendelsohn M, Jessell TM
Neuron. 2006
PubMed ID: 17145500
Crystal structure of Rac1 bound to its effector phospholipase C-beta2.
Jezyk MR, Snyder JT, Gershberg S, Worthylake DK, Harden TK, Sondek J
Nat Struct Mol Biol. 2006
PubMed ID: 17115053
Differential effects of systemic ethanol administration on protein kinase cepsilon, gamma, and beta isoform expression, membrane translocation, and target phosphorylation: reversal by chronic ethanol exposure.
Kumar S, Lane BM, Morrow AL
J Pharmacol Exp Ther. 2006
PubMed ID: 16997974
Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor.
Grodsky N, Li Y, Bouzida D, Love R, Jensen J, Nodes B, Nonomiya J, Grant S
Biochemistry. 2006
PubMed ID: 17115692
Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice.
Ohshiro Y, Ma RC, Yasuda Y, Hiraoka-Yamamoto J, Clermont AC, Isshiki K, Yagi K, Arikawa E, Kern TS, King GL
Diabetes. 2006
PubMed ID: 17065350
PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144.
Wang H, Grant JE, Doede CM, Sadayappan S, Robbins J, Walker JW
J Mol Cell Cardiol. 2006
PubMed ID: 17010989
Expression of protein kinase C isoenzymes alpha, betaI, and delta in subtypes of intercalated cells of mouse kidney.
Kim WY, Jung JH, Park EY, Yang CW, Kim H, Nielsen S, Madsen KM, Kim J
Am J Physiol Renal Physiol. 2006
PubMed ID: 16735462
Invariant Leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with Hsp70.
Gao T, Newton AC
J Biol Chem. 2006
PubMed ID: 16954220
Protein kinase C beta and delta isoenzymes mediate cholesterol accumulation in PMA-activated macrophages.
Ma HT, Lin WW, Zhao B, Wu WT, Huang W, Li Y, Jones NL, Kruth HS
Biochem Biophys Res Commun. 2006
PubMed ID: 16930534
Protein kinase Cbeta isoform down-regulates the expression of MDR3 P-glycoprotein in human Chang liver cells.
Suzuki S, Hayashi H, Takagi K, Kondo T, Takagi K, Ueyama J, Wakusawa S
Biochim Biophys Acta. 2006
PubMed ID: 16854530
Role of angiotensin II type 1A receptor phosphorylation, phospholipase D, and extracellular calcium in isoform-specific protein kinase C membrane translocation responses.
Policha A, Daneshtalab N, Chen L, Dale LB, Altier C, Khosravani H, Thomas WG, Zamponi GW, Ferguson SS
J Biol Chem. 2006
PubMed ID: 16831865
Control of cardiac myofilament activation and PKC-betaII signaling through the actin capping protein, CapZ.
Pyle WG, La Rotta G, de Tombe PP, Sumandea MP, Solaro RJ
J Mol Cell Cardiol. 2006
PubMed ID: 16870209
Homocysteine stimulates phosphorylation of NADPH oxidase p47phox and p67phox subunits in monocytes via protein kinase Cbeta activation.
Siow YL, Au-Yeung KK, Woo CW, O K
Biochem J. 2006
PubMed ID: 16626305
Glomerular clusterin is associated with PKC-alpha/beta regulation and good outcome of membranous glomerulonephritis in humans.
Rastaldi MP, Candiano G, Musante L, Bruschi M, Armelloni S, Rimoldi L, Tardanico R, Sanna-Cherchi S, Cherchi SS, Ferrario F, Montinaro V, Haupt R, Parodi S, Carnevali ML, Allegri L, Camussi G, Gesualdo L, Scolari F, Ghiggeri GM
Kidney Int. 2006
PubMed ID: 16775601
Chronic PKC-beta activation in HT-29 Cl.19a colonocytes prevents cAMP-mediated ion secretion by inhibiting apical membrane current generation.
Broughman JR, Sun L, Umar S, Scott J, Sellin JH, Morris AP
Am J Physiol Gastrointest Liver Physiol. 2006
PubMed ID: 16574993
Chronic PKC-beta2 activation in HT-29 Cl.19a colonocytes prevents cAMP-mediated ion secretion by inhibiting apical membrane CFTR targeting.
Broughman JR, Sun L, Umar S, Sellin JH, Morris AP
Am J Physiol Gastrointest Liver Physiol. 2006
PubMed ID: 16574992
Heterogeneity of cellular proliferation within transitional cell carcinoma: correlation of protein kinase C alpha/betaI expression and activity.
Aaltonen V, Koivunen J, Laato M, Peltonen J
J Histochem Cytochem. 2006
PubMed ID: 16517978
Selective role of PKCbeta enzymatic function in regulating cell survival mediated by B cell antigen receptor cross-linking.
Venkataraman C, Chen XC, Na S, Lee L, Neote K, Tan SL
Immunol Lett. 2006
PubMed ID: 16564096
Comprehensive identification of phosphorylation sites in postsynaptic density preparations.
Trinidad JC, Specht CG, Thalhammer A, Schoepfer R, Burlingame AL
Mol Cell Proteomics. 2006
PubMed ID: 16452087
Protein kinase C can inhibit TRPC3 channels indirectly via stimulating protein kinase G.
Kwan HY, Huang Y, Yao X
J Cell Physiol. 2006
PubMed ID: 16331690
Selective regulation of IL-10 signaling and function by zymosan.
Du Z, Kelly E, Mecklenbräuker I, Agle L, Herrero C, Paik P, Ivashkiv LB
J Immunol. 2006
PubMed ID: 16585572
Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.
Itoh S, Ding B, Shishido T, Lerner-Marmarosh N, Wang N, Maekawa N, Berk BC, Takeishi Y, Yan C, Blaxall BC, Abe J
Circulation. 2006
PubMed ID: 16585392
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Polymorphisms of the protein kinase C-beta gene (PRKCB1) accelerate kidney disease in type 2 diabetes without overt proteinuria.
Araki S, Haneda M, Sugimoto T, Isono M, Isshiki K, Kashiwagi A, Koya D
Diabetes Care. 2006
PubMed ID: 16567829
Insulin inhibits phagocytosis in normal human neutrophils via PKCalpha/beta-dependent priming of F-actin assembly.
Saiepour D, Sehlin J, Oldenborg PA
Inflamm Res. 2006
PubMed ID: 16673150
Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance.
Naruse K, Rask-Madsen C, Takahara N, Ha SW, Suzuma K, Way KJ, Jacobs JR, Clermont AC, Ueki K, Ohshiro Y, Zhang J, Goldfine AB, King GL
Diabetes. 2006
PubMed ID: 16505232
Chondrocyte cell death mediated by reactive oxygen species-dependent activation of PKC-betaI.
DelCarlo M, Loeser RF
Am J Physiol Cell Physiol. 2006
PubMed ID: 16236825
T-independent type II immune responses generate memory B cells.
Obukhanych TV, Nussenzweig MC
J Exp Med. 2006
PubMed ID: 16476769
Expression of protein kinase C isoforms in cardiac hypertrophy and heart failure due to volume overload.
Sentex E, Wang X, Liu X, Lukas A, Dhalla NS
Can J Physiol Pharmacol. 2006
PubMed ID: 16900949
The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration.
Volkov Y, Long A, Freeley M, Golden-Mason L, O'Farrelly C, Murphy A, Kelleher D
Gastroenterology. 2006
PubMed ID: 16472601
Mesangial cell NADPH oxidase upregulation in high glucose is protein kinase C dependent and required for collagen IV expression.
Xia L, Wang H, Goldberg HJ, Munk S, Fantus IG, Whiteside CI
Am J Physiol Renal Physiol. 2006
PubMed ID: 16131649
Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation.
Zhou Y, Wang D, Li F, Shi J, Song J
Int J Biochem Cell Biol. 2006
PubMed ID: 16950644
Effects of blocking the renin-angiotensin system on expression and translocation of protein kinase C isoforms in the kidney of diabetic rats.
Zhang L, Ma J, Gu Y, Lin S
Nephron Exp Nephrol. 2006
PubMed ID: 16837815
Mice lacking protein kinase C beta present modest increases in systolic blood pressure and NH4Cl-induced metabolic acidosis.
Yao LJ, Leitges M, Vallon V
Kidney Blood Press Res. 2006
PubMed ID: 16582576
Agents that act by different mechanisms modulate the activity of protein kinase CbetaII isozyme in the rat spinal cord during peripheral inflammation.
Igwe OJ
Neuroscience. 2006
PubMed ID: 16360284
Phosphorylation of the CARMA1 linker controls NF-kappaB activation.
Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ
Immunity. 2005
PubMed ID: 16356855
Critical role of protein kinase C betaII in activation of mast cells by monomeric IgE.
Liu Y, Furuta K, Teshima R, Shirata N, Sugimoto Y, Ichikawa A, Tanaka S
J Biol Chem. 2005
PubMed ID: 16183638
PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.
Shinohara H, Yasuda T, Aiba Y, Sanjo H, Hamadate M, Watarai H, Sakurai H, Kurosaki T
J Exp Med. 2005
PubMed ID: 16301747
Protein kinase C alpha, betaI, and betaII isozymes regulate cytokine production in mast cells through MEKK2/ERK5-dependent and -independent pathways.
Li G, Lucas JJ, Gelfand EW
Cell Immunol. 2005
PubMed ID: 16430878
Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells.
Woo MS, Jung SH, Kim SY, Hyun JW, Ko KH, Kim WK, Kim HS
Biochem Biophys Res Commun. 2005
PubMed ID: 16102725
Expression profile of protein kinase C isozymes in preimplantation mouse development.
Dehghani H, Hahnel AC
Reproduction. 2005
PubMed ID: 16183862
Activation of protein kinase CbetaI constitutes a new neurotrophic pathway for deafferented spiral ganglion neurons.
Lallemend F, Hadjab S, Hans G, Moonen G, Lefebvre PP, Malgrange B
J Cell Sci. 2005
PubMed ID: 16179609
Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism.
Philippi A, Roschmann E, Tores F, Lindenbaum P, Benajou A, Germain-Leclerc L, Marcaillou C, Fontaine K, Vanpeene M, Roy S, Maillard S, Decaulne V, Saraiva JP, Brooks P, Rousseau F, Hager J
Mol Psychiatry. 2005
PubMed ID: 16027742
Increases in intracellular calcium dephosphorylate histone H3 at serine 10 in human hepatoma cells: potential role of protein phosphatase 2A-protein kinase CbetaII complex.
Huang W, Batra S, Atkins BA, Mishra V, Mehta KD
J Cell Physiol. 2005
PubMed ID: 15880462
Protein kinase C delta stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest.
Santiago-Walker AE, Fikaris AJ, Kao GD, Brown EJ, Kazanietz MG, Meinkoth JL
J Biol Chem. 2005
PubMed ID: 16051606
Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis.
Roggero CM, Tomes CN, De Blas GA, Castillo J, Michaut MA, Fukuda M, Mayorga LS
Dev Biol. 2005
PubMed ID: 16111671
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Genes encoding catalytic subunits of protein kinase A and risk of spina bifida.
Zhu H, Lu W, Laurent C, Shaw GM, Lammer EJ, Finnell RH
Birth Defects Res A Clin Mol Teratol. 2005
PubMed ID: 16080189
The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts.
Graff JR, McNulty AM, Hanna KR, Konicek BW, Lynch RL, Bailey SN, Banks C, Capen A, Goode R, Lewis JE, Sams L, Huss KL, Campbell RM, Iversen PW, Neubauer BL, Brown TJ, Musib L, Geeganage S, Thornton D
Cancer Res. 2005
PubMed ID: 16103100
Protein kinase C betaII plays an essential role in dendritic cell differentiation and autoregulates its own expression.
Cejas PJ, Carlson LM, Zhang J, Padmanabhan S, Kolonias D, Lindner I, Haley S, Boise LH, Lee KP
J Biol Chem. 2005
PubMed ID: 15917249
PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.
Lu W, Ziff EB
Neuron. 2005
PubMed ID: 16055064
Protein kinase C betaII peptide inhibitor exerts cardioprotective effects in rat cardiac ischemia/reperfusion injury.
Omiyi D, Brue RJ, Taormina P, Harvey M, Atkinson N, Young LH
J Pharmacol Exp Ther. 2005
PubMed ID: 15878997
Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway.
Du Z, Shen Y, Yang W, Mecklenbrauker I, Neel BG, Ivashkiv LB
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16000408
Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on Serine 839 regulates Ca2+ oscillations.
Kim CH, Braud S, Isaac JT, Roche KW
J Biol Chem. 2005
PubMed ID: 15894802
Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells.
Alemán G, Ortíz V, Langley E, Tovar AR, Torres N
Am J Physiol Endocrinol Metab. 2005
PubMed ID: 15741241
Activated proteinkinase B in breast cancer.
Shcherbakov AM, Gershtein ES, Anurova OA, Kushlinskii NE
Bull Exp Biol Med. 2005
PubMed ID: 16224561
Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases.
Kitaura J, Eto K, Kinoshita T, Kawakami Y, Leitges M, Lowell CA, Kawakami T
J Immunol. 2005
PubMed ID: 15814670
Smad6s regulates plasminogen activator inhibitor-1 through a protein kinase C-beta-dependent up-regulation of transforming growth factor-beta.
Berg DT, Myers LJ, Richardson MA, Sandusky G, Grinnell BW
J Biol Chem. 2005
PubMed ID: 15716278
Role of protein kinase C beta in phorbol ester-induced c-fos gene expression in neurons of normotensive and spontaneously hypertensive rat brains.
Amemiya T, Kambe T, Fukumori R, Kubo T
Brain Res. 2005
PubMed ID: 15804434
RasGRP3 mediates phorbol ester-induced, protein kinase C-independent exocytosis.
Ozaki N, Miura Y, Yamada T, Kato Y, Oiso Y
Biochem Biophys Res Commun. 2005
PubMed ID: 15737652
Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40.
Patel NA, Kaneko S, Apostolatos HS, Bae SS, Watson JE, Davidowitz K, Chappell DS, Birnbaum MJ, Cheng JQ, Cooper DR
J Biol Chem. 2005
PubMed ID: 15684423
Regulation of amphetamine-stimulated dopamine efflux by protein kinase C beta.
Johnson LA, Guptaroy B, Lund D, Shamban S, Gnegy ME
J Biol Chem. 2005
PubMed ID: 15647254
Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.
van Baal J, de Widt J, Divecha N, van Blitterswijk WJ
J Biol Chem. 2005
PubMed ID: 15632189
Central role of PKCbeta in neointimal expansion triggered by acute arterial injury.
Andrassy M, Belov D, Harja E, Zou YS, Leitges M, Katus HA, Nawroth PP, Yan SD, Schmidt AM, Yan SF
Circ Res. 2005
PubMed ID: 15662033
Modulation of erythrocyte membrane mechanical function by protein 4.1 phosphorylation.
Manno S, Takakuwa Y, Mohandas N
J Biol Chem. 2005
PubMed ID: 15611095
CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade.
Moreno-García ME, López-Bojórques LN, Zentella A, Humphries LA, Rawlings DJ, Santos-Argumedo L
J Immunol. 2005
PubMed ID: 15728476
Modification of PI3K- and MAPK-dependent chemotaxis in aortic vascular smooth muscle cells by protein kinase CbetaII.
Campbell M, Trimble ER
Circ Res. 2005
PubMed ID: 15591231
Sodium butyrate-mediated differentiation of colorectal cancer cells: regulation of PKCbetaII by PI 3-kinase.
Turecková J, Vojtechová M, Kucerová D, Velek J, Tuhácková Z
Int J Mol Med. 2005
PubMed ID: 15647851
Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway.
Becker KP, Kitatani K, Idkowiak-Baldys J, Bielawski J, Hannun YA
J Biol Chem. 2005
PubMed ID: 15546881
Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120.
Langford D, Hurford R, Hashimoto M, Digicaylioglu M, Masliah E
BMC Neurosci. 2005
PubMed ID: 15689238
Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}.
Devaraj S, Venugopal SK, Singh U, Jialal I
Diabetes. 2005
PubMed ID: 15616014
Protein kinase C isoforms differentially phosphorylate human choline acetyltransferase regulating its catalytic activity.
Dobransky T, Doherty-Kirby A, Kim AR, Brewer D, Lajoie G, Rylett RJ
J Biol Chem. 2004
PubMed ID: 15381704
Altered protein kinase C activation associated with rat embryonic dysmorphogenesis.
Gäreskog M, Wentzel P
Pediatr Res. 2004
PubMed ID: 15496608
Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation.
Aiba Y, Oh-hora M, Kiyonaka S, Kimura Y, Hijikata A, Mori Y, Kurosaki T
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15545601
Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.
Kawakami Y, Nishimoto H, Kitaura J, Maeda-Yamamoto M, Kato RM, Littman DR, Leitges M, Rawlings DJ, Kawakami T
J Biol Chem. 2004
PubMed ID: 15364915
IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes.
Contreras X, Bennasser Y, Bahraoui E
Microbes Infect. 2004
PubMed ID: 15488737
Protein kinase C activity regulates the onset of anaphase I in mouse oocytes.
Viveiros MM, O'brien M, Eppig JJ
Biol Reprod. 2004
PubMed ID: 15229137
Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo.
Liu Y, Su W, Thompson EA, Leitges M, Murray NR, Fields AP
J Biol Chem. 2004
PubMed ID: 15322124
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Polymorphisms in the 5'-upstream region of the PKCbeta gene in Japanese patients with Type 2 diabetes.
Ikeda Y, Suehiro T, Osaki F, Tsuzura S, Kumon Y, Hashimoto K
Diabet Med. 2004
PubMed ID: 15384959
Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia.
Ueyama T, Lennartz MR, Noda Y, Kobayashi T, Shirai Y, Rikitake K, Yamasaki T, Hayashi S, Sakai N, Seguchi H, Sawada M, Sumimoto H, Saito N
J Immunol. 2004
PubMed ID: 15383592
Regulation of spontaneous meiosis resumption in mouse oocytes by various conventional PKC isozymes depends on cellular compartmentalization.
Avazeri N, Courtot AM, Lefevre B
J Cell Sci. 2004
PubMed ID: 15367584
High expression of PKC-MAPK pathway mRNAs correlates with glomerular lesions in human diabetic nephropathy.
Toyoda M, Suzuki D, Honma M, Uehara G, Sakai T, Umezono T, Sakai H
Kidney Int. 2004
PubMed ID: 15327405
High concentration of glucose inhibits glomerular endothelial eNOS through a PKC mechanism.
Chu S, Bohlen HG
Am J Physiol Renal Physiol. 2004
PubMed ID: 15140758
The receptor for activated C-kinase-I (RACK-I) anchors activated PKC-beta on melanosomes.
Park HY, Wu H, Killoran CE, Gilchrest BA
J Cell Sci. 2004
PubMed ID: 15252133
Isoenzyme-specific translocation of protein kinase C (PKC)betaII and not PKCbetaI to a juxtanuclear subset of recycling endosomes: involvement of phospholipase D.
Becker KP, Hannun YA
J Biol Chem. 2004
PubMed ID: 15067001
PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters.
Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM
Mol Pharmacol. 2004
PubMed ID: 15213298
PKCbeta regulates ischemia/reperfusion injury in the lung.
Fujita T, Asai T, Andrassy M, Stern DM, Pinsky DJ, Zou YS, Okada M, Naka Y, Schmidt AM, Yan SF
J Clin Invest. 2004
PubMed ID: 15173888
Protein kinase C beta is dispensable for TCR-signaling.
Thuille N, Gruber T, Böck G, Leitges M, Baier G
Mol Immunol. 2004
PubMed ID: 15163535
Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway.
Zhang J, Anastasiadis PZ, Liu Y, Thompson EA, Fields AP
J Biol Chem. 2004
PubMed ID: 15037605
Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.
Hassel S, Eichner A, Yakymovych M, Hellman U, Knaus P, Souchelnytskyi S
Proteomics. 2004
PubMed ID: 15188402
Mapping a chromosomal locus for valproic acid-induced exencephaly in mice.
Lundberg YW, Cabrera RM, Greer KA, Zhao J, Garg R, Finnell RH
Mamm Genome. 2004
PubMed ID: 15170225
Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton.
Harrison RE, Sikorski BA, Jongstra J
J Cell Sci. 2004
PubMed ID: 15090600
Translocation of protein kinase C-betaII in astrocytes requires organized actin cytoskeleton and is not accompanied by synchronous RACK1 relocation.
Pascale A, Alkon DL, Grimaldi M
Glia. 2004
PubMed ID: 15042584
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C.
Nery FC, Passos DO, Garcia VS, Kobarg J
J Biol Chem. 2004
PubMed ID: 14699138
High glucose-induced membrane translocation of PKC betaI is associated with Arf6 in glomerular mesangial cells.
Padival AK, Hawkins KS, Huang C
Mol Cell Biochem. 2004
PubMed ID: 15030177
Effect of PKCbeta on retinal oxygenation response in experimental diabetes.
Luan H, Leitges M, Gupta RR, Pacheco D, Seidner A, Liggett J, Ito Y, Kowluru R, Berkowitz BA
Invest Ophthalmol Vis Sci. 2004
PubMed ID: 14985314
PKC-beta1 isoform activation is required for EGF-induced NF-kappaB inactivation and IkappaBalpha stabilization and protection of F-actin assembly and barrier function in enterocyte monolayers.
Banan A, Zhang LJ, Farhadi A, Fields JZ, Shaikh M, Keshavarzian A
Am J Physiol Cell Physiol. 2004
PubMed ID: 14602581
Centrosomal anchoring of protein kinase C betaII by pericentrin controls microtubule organization, spindle function, and cytokinesis.
Chen D, Purohit A, Halilovic E, Doxsey SJ, Newton AC
J Biol Chem. 2004
PubMed ID: 14594954
Effects of the antiandrogen flutamide on the expression of protein kinase C isoenzymes in LNCaP and PC3 human prostate cancer cells.
Montalvo L, Carmena MJ, Bolaños O, Rodríguez-Henche N, Sánchez-Chapado M, Prieto JC
Biosci Rep. 2004
PubMed ID: 15499829
Protein kinase betaII in Zucker obese rats compromises oxygen and flow-mediated regulation of nitric oxide formation.
Bohlen HG
Am J Physiol Heart Circ Physiol. 2004
PubMed ID: 14715497
A chromatin immunoprecipitation screen reveals protein kinase Cbeta as a direct RUNX1 target gene.
Hug BA, Ahmed N, Robbins JA, Lazar MA
J Biol Chem. 2004
PubMed ID: 14561740
In vivo expression of classic PKC isoforms in the rat dental follicle as related to tooth eruption.
Yao S, Wise G
Connect Tissue Res. 2004
PubMed ID: 15763930
Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus.
Tang FR, Lee WL, Gao H, Chen Y, Loh YT, Chia SC
Hippocampus. 2004
PubMed ID: 15058486
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol.
Cogram P, Hynes A, Dunlevy LP, Greene ND, Copp AJ
Hum Mol Genet. 2004
PubMed ID: 14613966
cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes.
Becker KP, Hannun YA
J Biol Chem. 2003
PubMed ID: 14527960
Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly.
Ceci M, Gaviraghi C, Gorrini C, Sala LA, Offenhäuser N, Marchisio PC, Biffo S
Nature. 2003
PubMed ID: 14654845
Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2.
Lorenz K, Lohse MJ, Quitterer U
Nature. 2003
PubMed ID: 14654844
Resistance to acute silicosis in senescent rats: role of alveolar macrophages.
Corsini E, Giani A, Lucchi L, Peano S, Viviani B, Galli CL, Marinovich M
Chem Res Toxicol. 2003
PubMed ID: 14680365
Overexpression of PKC-betaI and -delta contributes to higher PKC activity in the proximal tubules of old Fischer 344 rats.
Asghar M, Hussain T, Lokhandwala MF
Am J Physiol Renal Physiol. 2003
PubMed ID: 12904329
Protein kinase C-beta-mediated complex formation between tyrosinase and TRP-1.
Wu H, Park HY
Biochem Biophys Res Commun. 2003
PubMed ID: 14623273
Dominant negative protein kinase Cbeta improves 1alpha, 25-dihydroxy vitamin D3-induced insulin resistance.
Natsume Y, Ishizuka T, Yamamoto Y, Miura A, Kajita K, Ishizawa M, Kawai Y, Huang Y, Morita H, Uno Y, Yasuda K
Endocr Res. 2003
PubMed ID: 14682474
PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells.
Wang WL, Yeh SF, Chang YI, Hsiao SF, Lian WN, Lin CH, Huang CY, Lin WJ
J Biol Chem. 2003
PubMed ID: 12826667
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ
Science. 2003
PubMed ID: 12958364
Physiological regulation of Munc18/nSec1 phosphorylation on serine-313.
Craig TJ, Evans GJ, Morgan A
J Neurochem. 2003
PubMed ID: 12950453
Protein kinase Cbeta1, a major regulator of TCR-CD28-activated signal transduction leading to IL-2 gene transcription and secretion.
Dreikhausen UE, Gorf K, Resch K, Szamel M
Int Immunol. 2003
PubMed ID: 12917261
Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3.
Teixeira C, Stang SL, Zheng Y, Beswick NS, Stone JC
Blood. 2003
PubMed ID: 12730099
A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.
Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton AC, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12881490
Intestinal sugar absorption is regulated by phosphorylation and turnover of protein kinase C betaII mediated by phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent pathways.
Helliwell PA, Rumsby MG, Kellett GL
J Biol Chem. 2003
PubMed ID: 12766174
Protein kinase C beta is required for human monocyte chemotaxis to MCP-1.
Carnevale KA, Cathcart MK
J Biol Chem. 2003
PubMed ID: 12724308
Participation of phospholipase D and alpha/beta-protein kinase C in growth factor-induced signalling in C3H10T1/2 fibroblasts.
Thorsen VA, Vorland M, Bjørndal B, Bruland O, Holmsen H, Lillehaug JR
Biochim Biophys Acta. 2003
PubMed ID: 12782152
EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland.
Koyama N, Kashimata M, Sakashita H, Sakagami H, Gresik EW
Dev Dyn. 2003
PubMed ID: 12761849
Evidence for the involvement of a phospholipase C--protein kinase C signaling pathway in insulin stimulated glucose transport in skeletal muscle.
Wright DC, Fick CA, Olesen JB, Craig BW
Life Sci. 2003
PubMed ID: 12726887
Neural cell adhesion molecule (NCAM) association with PKCbeta2 via betaI spectrin is implicated in NCAM-mediated neurite outgrowth.
Leshchyns'ka I, Sytnyk V, Morrow JS, Schachner M
J Cell Biol. 2003
PubMed ID: 12743109
Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats.
Koide Y, Tamura K, Suzuki A, Kitamura K, Yokoyama K, Hashimoto T, Hirawa N, Kihara M, Ohno S, Umemura S
Hypertens Res. 2003
PubMed ID: 12887134
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J
Nat Biotechnol. 2003
PubMed ID: 12665801
Threonine phosphorylation sites in the beta 2 and beta 7 leukocyte integrin polypeptides.
Hilden TJ, Valmu L, Kärkkäinen S, Gahmberg CG
J Immunol. 2003
PubMed ID: 12682249
Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.
Chikamori K, Grabowski DR, Kinter M, Willard BB, Yadav S, Aebersold RH, Bukowski RM, Hickson ID, Andersen AH, Ganapathi R, Ganapathi MK
J Biol Chem. 2003
PubMed ID: 12569090
Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein.
Corbit KC, Trakul N, Eves EM, Diaz B, Marshall M, Rosner MR
J Biol Chem. 2003
PubMed ID: 12551925
Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase.
Yang XL, Zhang YL, Lai ZS, Xing FY, Liu YH
World J Gastroenterol. 2003
PubMed ID: 12679936
Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis.
Barclay JW, Craig TJ, Fisher RJ, Ciufo LF, Evans GJ, Morgan A, Burgoyne RD
J Biol Chem. 2003
PubMed ID: 12519779
Differentiation of nonbeating embryonic stem cells into beating cardiomyocytes is dependent on downregulation of PKC beta and zeta in concert with upregulation of PKC epsilon.
Zhou X, Quann E, Gallicano GI
Dev Biol. 2003
PubMed ID: 12648500
Participation of protein kinase C beta in osteoclast differentiation and function.
Lee SW, Kwak HB, Chung WJ, Cheong H, Kim HH, Lee ZH
Bone. 2003
PubMed ID: 12667549
Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells.
Chen S, Anderson PO, Li L, Sjögren HO, Wang P, Li SL
Int Immunol. 2003
PubMed ID: 12618484
Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension.
Kelly DJ, Zhang Y, Hepper C, Gow RM, Jaworski K, Kemp BE, Wilkinson-Berka JL, Gilbert RE
Diabetes. 2003
PubMed ID: 12540629
Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior.
Birikh KR, Sklan EH, Shoham S, Soreq H
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12509514
PH domain of G protein-coupled receptor kinase-2 binds to protein kinase C (PKC) and negatively regulates activity of PKC kinase.
Ji S, Liu X, Li S, Shen L, Li F, Wang J, Han J, Yao L
Front Biosci. 2003
PubMed ID: 12456365
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Ca2+-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor require negative feedback by protein kinase C.
Young SH, Wu SV, Rozengurt E
J Biol Chem. 2002
PubMed ID: 12356761
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Inhibition of PKCbeta improves glucocorticoid-induced insulin resistance in rat adipocytes.
Kawai Y, Ishizuka T, Kajita K, Miura A, Ishizawa M, Natsume Y, Uno Y, Morita H, Yasuda K
IUBMB Life. 2002
PubMed ID: 12665248
Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E
Virology. 2002
PubMed ID: 12482669
Protein kinase C beta (PKC beta): normal functions and diseases.
Kawakami T, Kawakami Y, Kitaura J
J Biochem. 2002
PubMed ID: 12417015
Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta.
Inagaki K, Iwanaga Y, Sarai N, Onozawa Y, Takenaka H, Mochly-Rosen D, Kihara Y
J Mol Cell Cardiol. 2002
PubMed ID: 12392998
Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages.
Todt JC, Hu B, Punturieri A, Sonstein J, Polak T, Curtis JL
J Biol Chem. 2002
PubMed ID: 12114511
The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-beta I and -delta.
Goldberg HJ, Whiteside CI, Fantus IG
J Biol Chem. 2002
PubMed ID: 12105191
Biphasic regulation of plasminogen activator/inhibitor by LDL in mesangial cells.
Song CY, Kim BC, Hong HK, Kim BK, Kim YS, Lee HS
Am J Physiol Renal Physiol. 2002
PubMed ID: 12167592
The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C.
Gao T, Newton AC
J Biol Chem. 2002
PubMed ID: 12080070
PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.
Su TT, Guo B, Kawakami Y, Sommer K, Chae K, Humphries LA, Kato RM, Kang S, Patrone L, Wall R, Teitell M, Leitges M, Kawakami T, Rawlings DJ
Nat Immunol. 2002
PubMed ID: 12118249
Mobilization of protein kinase C in macrophages induced by Listeria monocytogenes affects its internalization and escape from the phagosome.
Wadsworth SJ, Goldfine H
Infect Immun. 2002
PubMed ID: 12117979
Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII.
Mayadevi M, Praseeda M, Kumar KS, Omkumar RV
Biochim Biophys Acta. 2002
PubMed ID: 12147342
PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments.
Qian Y, Baisden JM, Cherezova L, Summy JM, Guappone-Koay A, Shi X, Mast T, Pustula J, Zot HG, Mazloum N, Lee MY, Flynn DC
Mol Biol Cell. 2002
PubMed ID: 12134071
Phosphoinositide 3-kinase mediates protein kinase C beta II mRNA destabilization in rat A10 smooth muscle cell cultures exposed to high glucose.
Patel NA, Yamamoto M, Illingworth P, Mancu D, Mebert K, Chappell DS, Watson JE, Cooper DR
Arch Biochem Biophys. 2002
PubMed ID: 12061808
Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation.
Fontayne A, Dang PM, Gougerot-Pocidalo MA, El-Benna J
Biochemistry. 2002
PubMed ID: 12056906
Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha.
Saijo K, Mecklenbräuker I, Santana A, Leitger M, Schmedt C, Tarakhovsky A
J Exp Med. 2002
PubMed ID: 12070292
The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions.
Slater SJ, Ho C, Stubbs CD
Chem Phys Lipids. 2002
PubMed ID: 12093536
The beta 1 isoform of protein kinase C mediates the protective effects of epidermal growth factor on the dynamic assembly of F-actin cytoskeleton and normalization of calcium homeostasis in human colonic cells.
Banan A, Fields JZ, Farhadi A, Talmage DA, Zhang L, Keshavarzian A
J Pharmacol Exp Ther. 2002
PubMed ID: 12023512
Protein kinase C-beta II Is an apoptotic lamin kinase in polyomavirus-transformed, etoposide-treated pyF111 rat fibroblasts.
Chiarini A, Whitfield JF, Armato U, Dal Pra I
J Biol Chem. 2002
PubMed ID: 11901153
Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction.
Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S
Biochem Biophys Res Commun. 2002
PubMed ID: 12054501
Quantitative dynamics of site-specific protein phosphorylation determined using liquid chromatography electrospray ionization mass spectrometry.
Ruse CI, Willard B, Jin JP, Haas T, Kinter M, Bond M
Anal Chem. 2002
PubMed ID: 12033257
HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta.
Bennasser Y, Bahraoui E
FASEB J. 2002
PubMed ID: 11919157
Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
Fang X, Yu S, Tanyi JL, Lu Y, Woodgett JR, Mills GB
Mol Cell Biol. 2002
PubMed ID: 11884598
Enhancement of L-type Ca(2+) current from neonatal mouse ventricular myocytes by constitutively active PKC-betaII.
Alden KJ, Goldspink PH, Ruch SW, Buttrick PM, García J
Am J Physiol Cell Physiol. 2002
PubMed ID: 11880265
Nanomolar amyloid beta protein activates a specific PKC isoform mediating phosphorylation of MARCKS in Neuro2A cells.
Tanimukai S, Hasegawa H, Nakai M, Yagi K, Hirai M, Saito N, Taniguchi T, Terashima A, Yasuda M, Kawamata T, Tanaka C
Neuroreport. 2002
PubMed ID: 11930178
Inhibition of the calcium release-activated calcium (CRAC) current in Jurkat T cells by the HIV-1 envelope protein gp160.
Dellis O, Gangloff SC, Paulais M, Tondelier D, Rona JP, Brouillard F, Bouteau F, Guenounou M, Teulon J
J Biol Chem. 2002
PubMed ID: 11744714
Obligatory role of protein kinase Cbeta and MARCKS in vesicular trafficking in living neurons.
Yang H, Wang X, Sumners C, Raizada MK
Hypertension. 2002
PubMed ID: 11882609
Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization.
Suzuma K, Takahara N, Suzuma I, Isshiki K, Ueki K, Leitges M, Aiello LP, King GL
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11805327
Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes.
Fagerholm S, Morrice N, Gahmberg CG, Cohen P
J Biol Chem. 2002
PubMed ID: 11700305
The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta.
Strack V, Krützfeldt J, Kellerer M, Ullrich A, Lammers R, Häring HU
Biochemistry. 2002
PubMed ID: 11781100
Protein kinase C beta isoenzymes in diabetic kidneys and their relation to nephroprotective actions of the ACE inhibitor lisinopril.
Pfaff IL, Vallon V
Kidney Blood Press Res. 2002
PubMed ID: 12435880
Changes in protein kinase C (PKC) activity, isozyme translocation, and GAP-43 phosphorylation in the rat hippocampal formation after a single-trial contextual fear conditioning paradigm.
Young E, Cesena T, Meiri KF, Perrone-Bizzozero NI
Hippocampus. 2002
PubMed ID: 12201630
Possible involvement of PKC isoforms in signalling placental apoptosis in intrauterine growth retardation.
Sugden MC, Langdown ML
Mol Cell Endocrinol. 2001
PubMed ID: 11738801
Investigation of the inhibitory effects of chelerythrine chloride on the translocation of the protein kinase C betaI, betaII, zeta in human neutrophils.
Siomboing X, Gressier B, Dine T, Brunet C, Luyckx M, Cazin M, Cazin JC
Farmaco. 2001
PubMed ID: 11765038
Protein kinase C isoform expression and activity in the mouse heart.
Schreiber KL, Paquet L, Allen BG, Rindt H
Am J Physiol Heart Circ Physiol. 2001
PubMed ID: 11668067
Protein kinase C regulates the phosphorylation and cellular localization of occludin.
Andreeva AY, Krause E, Müller EC, Blasig IE, Utepbergenov DI
J Biol Chem. 2001
PubMed ID: 11502742
PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.
Kang SW, Wahl MI, Chu J, Kitaura J, Kawakami Y, Kato RM, Tabuchi R, Tarakhovsky A, Kawakami T, Turck CW, Witte ON, Rawlings DJ
EMBO J. 2001
PubMed ID: 11598012
Age-dependent activation of PKC isoforms by angiotensin II in the proximal nephron.
Boesch DM, Garvin JL
Am J Physiol Regul Integr Comp Physiol. 2001
PubMed ID: 11507002
HIV envelope gp120 activates human arterial smooth muscle cells.
Schecter AD, Berman AB, Yi L, Mosoian A, McManus CM, Berman JW, Klotman ME, Taubman MB
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11504923
Glycogen synthase kinase-3: properties, functions, and regulation.
Ali A, Hoeflich KP, Woodgett JR
Chem Rev. 2001
PubMed ID: 11749387
Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells.
Patel NA, Chalfant CE, Watson JE, Wyatt JR, Dean NM, Eichler DC, Cooper DR
J Biol Chem. 2001
PubMed ID: 11283022
Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase.
Chen L, Haider K, Ponda M, Cariappa A, Rowitch D, Pillai S
J Biol Chem. 2001
PubMed ID: 11278382
The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1.
Gao T, Toker A, Newton AC
J Biol Chem. 2001
PubMed ID: 11376011
Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current.
Liao GY, Wagner DA, Hsu MH, Leonard JP
Mol Pharmacol. 2001
PubMed ID: 11306676
PKC-beta is not necessary for cardiac hypertrophy.
Roman BB, Geenen DL, Leitges M, Buttrick PM
Am J Physiol Heart Circ Physiol. 2001
PubMed ID: 11299230
Regulation of the ErbB3 binding protein Ebp1 by protein kinase C.
Lessor TJ, Hamburger AW
Mol Cell Endocrinol. 2001
PubMed ID: 11325528
Activation of annexin 7 by protein kinase C in vitro and in vivo.
Caohuy H, Pollard HB
J Biol Chem. 2001
PubMed ID: 11278415
Roles for beta II-protein kinase C and RACK1 in positive and negative signaling for superoxide anion generation in differentiated HL60 cells.
Korchak HM, Kilpatrick LE
J Biol Chem. 2001
PubMed ID: 11120743
Essential activation of PKC-delta in opioid-initiated cardioprotection.
Fryer RM, Wang Y, Hsu AK, Gross GJ
Am J Physiol Heart Circ Physiol. 2001
PubMed ID: 11179083
Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.
Cunningham ML, Waldo GL, Hollinger S, Hepler JR, Harden TK
J Biol Chem. 2001
PubMed ID: 11063746
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.
Park IW, Wang JF, Groopman JE
Blood. 2001
PubMed ID: 11154208
Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst.
Dang PM, Fontayne A, Hakim J, El Benna J, Périanin A
J Immunol. 2001
PubMed ID: 11145703
[HIV-1 Tat protein induces IL-10 production by human monocytes: implications of the PKC and calcium pathway]
Bennasser Y, Yamina B, Contreras X, Xavier C, Moreau M, Marc M, Le Clerc C, Catherine L, Badou A, Abdallah B, Bahraoui E
J Soc Biol. 2001
PubMed ID: 11833470
Role of two conserved cytoplasmic threonine residues (T410 and T412) in CD5 signaling.
Vilà JM, Calvo J, Places L, Padilla O, Arman M, Gimferrer I, Aussel C, Vives J, Lozano F
J Immunol. 2001
PubMed ID: 11123317
Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium.
Huang MB, Bond VC
J Acquir Immune Defic Syndr. 2000
PubMed ID: 11141237
Expression of protein kinase C isozymes in nonpregnant and pregnant human myometrium.
Hurd WW, Fomin VP, Natarajan V, Brown HL, Bigsby RM, Singh DM
Am J Obstet Gynecol. 2000
PubMed ID: 11120522
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway.
Badou A, Bennasser Y, Moreau M, Leclerc C, Benkirane M, Bahraoui E
J Virol. 2000
PubMed ID: 11044099
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.
Fang X, Yu SX, Lu Y, Bast RC, Woodgett JR, Mills GB
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11035810
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Identification and characterization of PRKCBP1, a candidate RACK-like protein.
Fossey SC, Kuroda S, Price JA, Pendleton JK, Freedman BI, Bowden DW
Mamm Genome. 2000
PubMed ID: 11003709
Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets.
Chung SH, Polgar J, Reed GL
J Biol Chem. 2000
PubMed ID: 10856305
A role for the beta isoform of protein kinase C in fear conditioning.
Weeber EJ, Atkins CM, Selcher JC, Varga AW, Mirnikjoo B, Paylor R, Leitges M, Sweatt JD
J Neurosci. 2000
PubMed ID: 10934237
The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development.
Pauken CM, Capco DG
Dev Biol. 2000
PubMed ID: 10882525
Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.
Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG
Nat Neurosci. 2000
PubMed ID: 10862698
Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication.
Lampe PD, TenBroek EM, Burt JM, Kurata WE, Johnson RG, Lau AF
J Cell Biol. 2000
PubMed ID: 10871288
Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.
Mayne M, Holden CP, Nath A, Geiger JD
J Immunol. 2000
PubMed ID: 10843712
Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation.
Feng X, Becker KP, Stribling SD, Peters KG, Hannun YA
J Biol Chem. 2000
PubMed ID: 10828076
Protein kinase C-beta and oxygen deprivation. A novel Egr-1-dependent pathway for fibrin deposition in hypoxemic vasculature.
Yan SF, Lu J, Zou YS, Kisiel W, Mackman N, Leitges M, Steinberg S, Pinsky D, Stern D
J Biol Chem. 2000
PubMed ID: 10766820
Inhibition of degranulation and interleukin-6 production in mast cells derived from mice deficient in protein kinase Cbeta.
Nechushtan H, Leitges M, Cohen C, Kay G, Razin E
Blood. 2000
PubMed ID: 10688834
Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development.
Balasubramanian G, Amann JF, Reddy CS
J Craniofac Genet Dev Biol. 2000
PubMed ID: 10879655
A synthetic peptide derived from the non-structural protein 3 of hepatitis C virus serves as a specific substrate for PKC.
Borowski P, Resch K, Schmitz H, Heiland M
Biol Chem. 2000
PubMed ID: 10722046
Phosphorylation of HMG-I by protein kinase C attenuates its binding affinity to the promoter regions of protein kinase C gamma and neurogranin/RC3 genes.
Xiao DM, Pak JH, Wang X, Sato T, Huang FL, Chen HC, Huang KP
J Neurochem. 2000
PubMed ID: 10617144
HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system.
Idriss H, Kawa S, Damuni Z, Thompson EB, Wilson SH
Int J Biochem Cell Biol. 1999
PubMed ID: 10641798
Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery.
Tian R, Miao W, Spindler M, Javadpour MM, McKinney R, Bowman JC, Buttrick PM, Ingwall JS
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10557356
The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer.
Tseng CP, Ely BD, Pong RC, Wang Z, Zhou J, Hsieh JT
J Biol Chem. 1999
PubMed ID: 10542228
Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch.
Santy LC, Frank SR, Hatfield JC, Casanova JE
Curr Biol. 1999
PubMed ID: 10531036
Biochemical characterization of pKi67 with the identification of a mitotic-specific form associated with hyperphosphorylation and altered DNA binding.
MacCallum DE, Hall PA
Exp Cell Res. 1999
PubMed ID: 10502411
Effects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis.
Standaert ML, Bandyopadhyay G, Galloway L, Soto J, Ono Y, Kikkawa U, Farese RV, Leitges M
Endocrinology. 1999
PubMed ID: 10499500
Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates.
Tözsér J, Bagossi P, Boross P, Louis JM, Majerova E, Oroszlan S, Copeland TD
Eur J Biochem. 1999
PubMed ID: 10491200
Coordinated movement of RACK1 with activated betaIIPKC.
Ron D, Jiang Z, Yao L, Vagts A, Diamond I, Gordon A
J Biol Chem. 1999
PubMed ID: 10480917
Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.
Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD
Genomics. 1999
PubMed ID: 10493829
Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor.
Geijsen N, Spaargaren M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ
Oncogene. 1999
PubMed ID: 10490850
Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner.
Jain N, Zhang T, Kee WH, Li W, Cao X
J Biol Chem. 1999
PubMed ID: 10446219
HIV-1 Nef alters the expression of betaII and epsilon isoforms of protein kinase C and the activation of the long terminal repeat promoter in human astrocytoma cells.
Ambrosini E, Slepko N, Kohleisen B, Shumay E, Erfle V, Aloisi F, Levi G
Glia. 1999
PubMed ID: 10417813
Characterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase C.
Rodriguez MM, Chen CH, Smith BL, Mochly-Rosen D
FEBS Lett. 1999
PubMed ID: 10431815
Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C.
Zhou Q, Ruiz-Lozano P, Martone ME, Chen J
J Biol Chem. 1999
PubMed ID: 10391924
14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells.
Autieri MV, Carbone CJ
DNA Cell Biol. 1999
PubMed ID: 10433554
Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis.
Murray NR, Davidson LA, Chapkin RS, Clay Gustafson W, Schattenberg DG, Fields AP
J Cell Biol. 1999
PubMed ID: 10330400
Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation.
Fleming IN, Elliott CM, Buchanan FG, Downes CP, Exton JH
J Biol Chem. 1999
PubMed ID: 10212259
Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion.
Reed GL, Houng AK, Fitzgerald ML
Blood. 1999
PubMed ID: 10194441
Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart.
Bowling N, Walsh RA, Song G, Estridge T, Sandusky GE, Fouts RL, Mintze K, Pickard T, Roden R, Bristow MR, Sabbah HN, Mizrahi JL, Gromo G, King GL, Vlahos CJ
Circulation. 1999
PubMed ID: 9918525
Characterisation of non-structural protein 3 of hepatitis C virus as modulator of protein phosphorylation mediated by PKA and PKC: evidences for action on the level of substrate and enzyme.
Borowski P, Heiland M, Feucht H, Laufs R
Arch Virol. 1999
PubMed ID: 10365161
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Effect of ageing on the expression of protein kinase C and its activation by 1,25(OH)2-vitamin D3 in rat skeletal muscle.
Facchinetti MM, de Boland AR
Cell Signal. 1999
PubMed ID: 10206343
Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+.
Sutton RB, Sprang SR
Structure. 1998
PubMed ID: 9817842
Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals.
Oancea E, Meyer T
Cell. 1998
PubMed ID: 9814702
Elucidation of the exon-intron structure and size of the human protein kinase C beta gene (PRKCB).
Greenham J, Adams M, Doggett N, Mole S
Hum Genet. 1998
PubMed ID: 9856494
Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis.
Németh K, Salchert K, Putnoky P, Bhalerao R, Koncz-Kálmán Z, Stankovic-Stangeland B, Bakó L, Mathur J, Okrész L, Stabel S, Geigenberger P, Stitt M, Rédei GP, Schell J, Koncz C
Genes Dev. 1998
PubMed ID: 9765207
Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure.
Mahadev K, Vemuri MC
Arch Biochem Biophys. 1998
PubMed ID: 9705215
Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release.
Bai M, Trivedi S, Lane CR, Yang Y, Quinn SJ, Brown EM
J Biol Chem. 1998
PubMed ID: 9694886
Effects of phosphorylation on function of the Rad GTPase.
Moyers JS, Zhu J, Kahn CR
Biochem J. 1998
PubMed ID: 9677319
The molecular mechanism of B cell activation by toll-like receptor protein RP-105.
Chan VW, Mecklenbräuker I, Su I, Texido G, Leitges M, Carsetti R, Lowell CA, Rajewsky K, Miyake K, Tarakhovsky A
J Exp Med. 1998
PubMed ID: 9653087
Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways.
Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F
AIDS Res Hum Retroviruses. 1998
PubMed ID: 9671211
Distinct functions of protein kinase Calpha and protein kinase Cbeta during retinoic acid-induced differentiation of F9 cells.
Cho Y, Klein MG, Talmage DA
Cell Growth Differ. 1998
PubMed ID: 9486851
Regulation of protein kinase C in the muscular layer of human placental stem villi vessels.
Tertrin-Clary C, Fournier T, Ferré F
FEBS Lett. 1998
PubMed ID: 9475183
Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.
Borgatti P, Zauli G, Cantley LC, Capitani S
Biochem Biophys Res Commun. 1998
PubMed ID: 9446795
Two novel brain-specific splice variants of the murine Cbeta gene of cAMP-dependent protein kinase.
Guthrie CR, Skâlhegg BS, McKnight GS
J Biol Chem. 1997
PubMed ID: 9368018
Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.
Bowman JC, Steinberg SF, Jiang T, Geenen DL, Fishman GI, Buttrick PM
J Clin Invest. 1997
PubMed ID: 9410895
Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy.
Wakasaki H, Koya D, Schoen FJ, Jirousek MR, Ways DK, Hoit BD, Walsh RA, King GL
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9256480
Serine phosphorylation of syndecan-2 proteoglycan cytoplasmic domain.
Oh ES, Couchman JR, Woods A
Arch Biochem Biophys. 1997
PubMed ID: 9244383
Identification of the protein kinase C isoenzymes in human lung and airways smooth muscle at the protein and mRNA level.
Webb BL, Lindsay MA, Seybold J, Brand NJ, Yacoub MH, Haddad EB, Barnes PJ, Adcock IM, Giembycz MA
Biochem Pharmacol. 1997
PubMed ID: 9296367
Phosphorylation of vitronectin on Ser362 by protein kinase C attenuates its cleavage by plasmin.
Gechtman Z, Shaltiel S
Eur J Biochem. 1997
PubMed ID: 9030777
Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor.
Omkumar RV, Kiely MJ, Rosenstein AJ, Min KT, Kennedy MB
J Biol Chem. 1996
PubMed ID: 8940188
Protein-protein interaction of zinc finger LIM domains with protein kinase C.
Kuroda S, Tokunaga C, Kiyohara Y, Higuchi O, Konishi H, Mizuno K, Gill GN, Kikkawa U
J Biol Chem. 1996
PubMed ID: 8940095
The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.
Zappelli F, Willems D, Osada S, Ohno S, Wetsel WC, Molinaro M, Cossu G, Bouché M
Dev Biol. 1996
PubMed ID: 8948582
In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46.
Holmes AM
Arch Biochem Biophys. 1996
PubMed ID: 8914829
Developmental expression of MARCKS and protein kinase C in mice in relation to the exencephaly resulting from MARCKS deficiency.
Blackshear PJ, Lai WS, Tuttle JS, Stumpo DJ, Kennington E, Nairn AC, Sulik KK
Brain Res Dev Brain Res. 1996
PubMed ID: 8922669
Galpha12 and galpha13 are phosphorylated during platelet activation.
Offermanns S, Hu YH, Simon MI
J Biol Chem. 1996
PubMed ID: 8824244
Mapping of a regulatory important site for protein kinase C phosphorylation in the N-terminal domain of annexin II.
Jost M, Gerke V
Biochim Biophys Acta. 1996
PubMed ID: 8898866
Differential expression of protein kinase C isoforms in the human placenta.
Ruzycky AL, Jansson T, Illsley NP
Placenta. 1996
PubMed ID: 8899875
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Immunodeficiency in protein kinase cbeta-deficient mice.
Leitges M, Schmedt C, Guinamard R, Davoust J, Schaal S, Stabel S, Tarakhovsky A
Science. 1996
PubMed ID: 8670417
Phosphorylation of GAP-43 (growth-associated protein of 43 kDa) by conventional, novel and atypical isotypes of the protein kinase C gene family: differences between oligopeptide and polypeptide phosphorylation.
Oehrlein SA, Parker PJ, Herget T
Biochem J. 1996
PubMed ID: 8694767
Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control.
Kahl-Rainer P, Sedivy R, Marian B
Gastroenterology. 1996
PubMed ID: 8964400
Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins.
Whalen SG, Gingras AC, Amankwa L, Mader S, Branton PE, Aebersold R, Sonenberg N
J Biol Chem. 1996
PubMed ID: 8662663
Increased expression of protein kinase C beta activates ERK3.
Sauma S, Friedman E
J Biol Chem. 1996
PubMed ID: 8626698
Persistent membrane translocation of protein kinase C alpha during 12-0-tetradecanoylphorbol-13-acetate-induced apoptosis of LNCaP human prostate cancer cells.
Powell CT, Brittis NJ, Stec D, Hug H, Heston WD, Fair WR
Cell Growth Differ. 1996
PubMed ID: 9052983
Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin.
Fujita Y, Sasaki T, Fukui K, Kotani H, Kimura T, Hata Y, Südhof TC, Scheller RH, Takai Y
J Biol Chem. 1996
PubMed ID: 8631738
Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes.
Conant K, Ma M, Nath A, Major EO
J Virol. 1996
PubMed ID: 8627654
IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C.
Parada NA, Cruikshank WW, Danis HL, Ryan TC, Center DM
Cell Immunol. 1996
PubMed ID: 8599832
PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163.
Palmer RH, Schönwasser DC, Rahman D, Pappin DJ, Herget T, Parker PJ
FEBS Lett. 1996
PubMed ID: 8557118
Activation of human platelet protein kinase C-beta 2 in vivo in response to acute hyperglycemia.
Pirags V, Assert R, Haupt K, Schatz H, Pfeiffer A
Exp Clin Endocrinol Diabetes. 1996
PubMed ID: 9021343
Protein kinase C is regulated in vivo by three functionally distinct phosphorylations.
Keranen LM, Dutil EM, Newton AC
Curr Biol. 1995
PubMed ID: 8749392
Cell cycle phase-specific phosphorylation of human topoisomerase II alpha. Evidence of a role for protein kinase C.
Wells NJ, Fry AM, Guano F, Norbury C, Hickson ID
J Biol Chem. 1995
PubMed ID: 7499337
The myristoylated alanine-rich C-kinase substrate (MARCKS) is sequentially phosphorylated by conventional, novel and atypical isotypes of protein kinase C.
Herget T, Oehrlein SA, Pappin DJ, Rozengurt E, Parker PJ
Eur J Biochem. 1995
PubMed ID: 7588787
HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells.
Chirmule N, Goonewardena H, Pahwa S, Pasieka R, Kalyanaraman VS, Pahwa S
J Biol Chem. 1995
PubMed ID: 7642615
Protein and molecular characterization of hippocampal protein kinase C in C57BL/6 and DBA/2 mice.
Bowers BJ, Christensen SC, Pauley JR, Paylor R, Yuva L, Dunbar SE, Wehner JM
J Neurochem. 1995
PubMed ID: 7760054
Distribution of the extended family of protein kinase C isoenzymes in fetal organs of mice: an immunohistochemical study.
Bareggi R, Grill V, Zweyer M, Narducci P, Martelli AM
Cell Tissue Res. 1995
PubMed ID: 7606770
The receptor-like protein-tyrosine phosphatase, RPTP alpha, is phosphorylated by protein kinase C on two serines close to the inner face of the plasma membrane.
Tracy S, van der Geer P, Hunter T
J Biol Chem. 1995
PubMed ID: 7537734
Localization of protein kinases by anchoring proteins: a theme in signal transduction.
Mochly-Rosen D
Science. 1995
PubMed ID: 7716516
Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity.
Zhu J, Reynet C, Caldwell JS, Kahn CR
J Biol Chem. 1995
PubMed ID: 7876254
Autoregulation of cloned human protein kinase C beta and gamma gene promoters in U937 cells.
Mahajna J, King P, Parker P, Haley J
DNA Cell Biol. 1995
PubMed ID: 7880442
Interleukin-3 or erythropoietin induced nuclear localization of protein kinase C beta isoforms in hematopoietic target cells.
Mason-Garcia M, Harlan RE, Mallia C, Jeter JR, Steinberg HB, Fermin C, Beckman BS
Cell Prolif. 1995
PubMed ID: 7734624
Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein.
Ward NE, Gravitt KR, O'Brian CA
Cancer Lett. 1995
PubMed ID: 7850771
Requirement for negative charge on "activation loop" of protein kinase C.
Orr JW, Newton AC
J Biol Chem. 1994
PubMed ID: 7961692
Cloning of a mouse protein kinase A catalytic subunit pseudogene and chromosomal mapping of C subunit isoforms.
Cummings DE, Edelhoff S, Disteche CM, McKnight GS
Mamm Genome. 1994
PubMed ID: 7873880
The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.
el Benna J, Faust LP, Babior BM
J Biol Chem. 1994
PubMed ID: 8089108
Phosphorylation of Thr642 is an early event in the processing of newly synthesized protein kinase C beta 1 and is essential for its activation.
Zhang J, Wang L, Schwartz J, Bond RW, Bishop WR
J Biol Chem. 1994
PubMed ID: 8034726
Identification of nuclear beta II protein kinase C as a mitotic lamin kinase.
Goss VL, Hocevar BA, Thompson LJ, Stratton CA, Burns DJ, Fields AP
J Biol Chem. 1994
PubMed ID: 8034666
An immunohistochemical study of protein kinase C distribution in fetal mouse vertebral column.
Bareggi R, Neri LM, Grill V, Cocco L, Martelli AM
Anat Embryol (Berl). 1994
PubMed ID: 7985811
A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.
Akimoto K, Mizuno K, Osada S, Hirai S, Tanuma S, Suzuki K, Ohno S
J Biol Chem. 1994
PubMed ID: 7513693
Dynamic properties of ankyrin in T lymphocytes: colocalization with spectrin and protein kinase C beta.
Gregorio CC, Repasky EA, Fowler VM, Black JD
J Cell Biol. 1994
PubMed ID: 8163551
Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report.
Gupta S, Aggarwal S, Kim C, Gollapudi S
Int J Immunopharmacol. 1994
PubMed ID: 8206685
Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C.
Blume-Jensen P, Siegbahn A, Stabel S, Heldin CH, Rönnstrand L
EMBO J. 1993
PubMed ID: 7693453
Characterization of a 7.5-kDa protein kinase C substrate (RC3 protein, neurogranin) from rat brain.
Huang KP, Huang FL, Chen HC
Arch Biochem Biophys. 1993
PubMed ID: 8080473
Characterization of site-specific mutants altered at protein kinase C beta 1 isozyme autophosphorylation sites.
Zhang J, Wang L, Petrin J, Bishop WR, Bond RW
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8327493
Reassignment of the H-ras-1 gene to the Hbb-terminus region of mouse chromosome 7.
Bianchi AB, Rinchik EM, Conti CJ
Mamm Genome. 1993
PubMed ID: 8499656
[Continuing education--cross-professional offer not sufficient]
Gass M
Sygeplejersken. 1992
PubMed ID: 1299012
Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters.
Obeid LM, Blobe GC, Karolak LA, Hannun YA
J Biol Chem. 1992
PubMed ID: 1400396
Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes.
Goode N, Hughes K, Woodgett JR, Parker PJ
J Biol Chem. 1992
PubMed ID: 1324914
Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor.
Moss SJ, Doherty CA, Huganir RL
J Biol Chem. 1992
PubMed ID: 1321150
Down-regulation of human protein kinase C alpha is associated with terminal neutrophil differentiation.
Devalia V, Thomas NS, Roberts PJ, Jones HM, Linch DC
Blood. 1992
PubMed ID: 1611098
A single cyclin A gene and multiple cyclin B1-related sequences are dispersed in the mouse genome.
Lock LF, Pines J, Hunter T, Gilbert DJ, Gopalan G, Jenkins NA, Copeland NG, Donovan PJ
Genomics. 1992
PubMed ID: 1535334
Positive and negative regulation of the transcription of the human protein kinase C beta gene.
Niino YS, Ohno S, Suzuki K
J Biol Chem. 1992
PubMed ID: 1556124
A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx.
Ruegg CL, Strand M
Cell Immunol. 1991
PubMed ID: 1832084
Phorbol diester-induced alterations in the expression of protein kinase C isozymes and their mRNAs. Analysis in wild-type and phorbol diester-resistant HL-60 cell clones.
McSwine-Kennick RL, McKeegan EM, Johnson MD, Morin MJ
J Biol Chem. 1991
PubMed ID: 1714454
Isolation of cloned mouse protein kinase C beta-II cDNA and its sequence.
Tang YM, Ashendel CL
Nucleic Acids Res. 1990
PubMed ID: 2402470
Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41.
Ruegg CL, Strand M
J Immunol. 1990
PubMed ID: 2139676
The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway.
Chowdhury IH, Koyanagi Y, Kobayashi S, Hamamoto Y, Yoshiyama H, Yoshida T, Yamamoto N
Virology. 1990
PubMed ID: 1970444
Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C.
Jakobovits A, Rosenthal A, Capon DJ
EMBO J. 1990
PubMed ID: 2182321
Identification of the protein kinase C phosphorylation site in neuromodulin.
Apel ED, Byford MF, Au D, Walsh KA, Storm DR
Biochemistry. 1990
PubMed ID: 2140056
Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a.
Wada H, Ohno S, Kubo K, Taya C, Tsuji S, Yonehara S, Suzuki K
Biochem Biophys Res Commun. 1989
PubMed ID: 2590242
Assignment of human genes for phosphorylase kinase subunits alpha (PHKA) to Xq12-q13 and beta (PHKB) to 16q12-q13.
Francke U, Darras BT, Zander NF, Kilimann MW
Am J Hum Genet. 1989
PubMed ID: 2757032
Human immunodeficiency virus induces phosphorylation of its cell surface receptor.
Fields AP, Bednarik DP, Hess A, May WS
Nature. 1988
PubMed ID: 3259291
Overproduction of protein kinase C causes disordered growth control in rat fibroblasts.
Housey GM, Johnson MD, Hsiao WL, O'Brian CA, Murphy JP, Kirschmeier P, Weinstein IB
Cell. 1988
PubMed ID: 3345563
Primary structures of human protein kinase C beta I and beta II differ only in their C-terminal sequences.
Kubo K, Ohno S, Suzuki K
FEBS Lett. 1987
PubMed ID: 3666134
Alternative splicing increases the diversity of the human protein kinase C family.
Coussens L, Rhee L, Parker PJ, Ullrich A
DNA. 1987
PubMed ID: 3677994
Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta I/beta II.
Kubo K, Ohno S, Suzuki K
Nucleic Acids Res. 1987
PubMed ID: 3658678
Expression and properties of two types of protein kinase C: alternative splicing from a single gene.
Ono Y, Kikkawa U, Ogita K, Fujii T, Kurokawa T, Asaoka Y, Sekiguchi K, Ase K, Igarashi K, Nishizuka Y
Science. 1987
PubMed ID: 3576226
Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family.
Housey GM, O'Brian CA, Johnson MD, Kirschmeier P, Weinstein IB
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3469647
Two types of complementary DNAs of rat brain protein kinase C. Heterogeneity determined by alternative splicing.
Ono Y, Kurokawa T, Fujii T, Kawahara K, Igarashi K, Kikkawa U, Ogita K, Nishizuka Y
FEBS Lett. 1986
PubMed ID: 2428667
Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.
Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A
Science. 1986
PubMed ID: 3755548
Cloning and expression of multiple protein kinase C cDNAs.
Knopf JL, Lee MH, Sultzman LA, Kriz RW, Loomis CR, Hewick RM, Bell RM
Cell. 1986
PubMed ID: 3755379
Cloning of rat brain protein kinase C complementary DNA.
Ono Y, Kurokawa T, Kawahara K, Nishimura O, Marumoto R, Igarashi K, Sugino Y, Kikkawa U, Ogita K, Nishizuka Y
FEBS Lett. 1986
PubMed ID: 3755404

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	5579	18751	25023
EnsEMBL Gene(s)	ENSG00000166501	ENSMUSG00000052889	ENSRNOG00000012061
Unigene	Hs.460355	Mm.207496	Rn.91118
Homologene	PRKCB	Prkcb	Prkcb
OMIM	176970	N/A	N/A
GeneCards	PRKCB	N/A	N/A
Beta Cell Genomics	DT.102834600 DT.120707986 DT.215913 DT.75186984	DT.532374 DT.94271981 DT.97356798	N/A
Reactome	P05771	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	5579	18751	25023

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
PRKCB	OCLN	HPRD	empirical	11502742
PRKCB	GNB2L1	HPRD, BioGRID	empirical	10480917
PRKCB	PDLIM5	HPRD, BioGRID	empirical	8940095
PRKCB	RBCK1	BioGRID	empirical	18303026 9514928
PRKCB	GNA13	HPRD, BioGRID	empirical	8824244
PRKCB	CHAT	HPRD	empirical	15381704
PRKCB	LDB3	MINT	empirical	10391924
PRKCB	CHUK	HPRD	empirical	12070292
PRKCB	CISH	HPRD	empirical	12618484
PRKCB	CSF2RB	HPRD, BioGRID	empirical	10490850
PRKCB	SYT6	HPRD	empirical	16111671
PRKCB	ADRBK1	HPRD, BioGRID	empirical	12456365 12679936
PRKCB	DAB2	HPRD	empirical	10542228
PRKCB	DVL2	HPRD	empirical	12958364
PRKCB	EIF4E	HPRD	empirical	8662663
PRKCB	EPB41	HPRD	empirical	15611095
PRKCB	HABP4	HPRD	empirical	14699138
PRKCB	DDX58	BioGRID	empirical	22114345
PRKCB	ZMYND8	HPRD	empirical	11003709
PRKCB	GABRB2	HPRD	empirical	1321150
PRKCB	GABRG2	HPRD	empirical	1321150
PRKCB	RASGRP3	HPRD, BioGRID	empirical	12730099 15213298
PRKCB	GAP43	HPRD	empirical	8694767 2140056
PRKCB	GCNT1	HPRD	empirical	12765965
PRKCB	GJA1	HPRD	empirical	10871288
PRKCB	GNA12	BioGRID	empirical	8824244
PRKCB	GRIN1	HPRD, IntAct	empirical	10862698 16635246
PRKCB	GRIN2B	HPRD, IntAct	empirical	12147342 8940188 11306676 16635246
PRKCB	GRIN2D	HPRD	empirical	10862698
PRKCB	GRM5	HPRD	empirical	15894802
PRKCB	GSK3A	HPRD	empirical	11035810 11884598 11749387 12054501
PRKCB	GSK3B	HPRD	empirical	1324914
PRKCB	ANXA2	HPRD	empirical	8898866
PRKCB	ANXA7	HPRD	empirical	11278415
PRKCB	HSPA4	BioGRID	empirical	16954220
PRKCB	IFNAR2	HPRD	empirical	16000408
PRKCB	IKBKB	HPRD	empirical	12070292
PRKCB	ITGB2	HPRD	empirical	11700305
PRKCB	EIF6	HPRD, IntAct	empirical	14654845 21665150
PRKCB	ITGB7	HPRD	empirical	12682249
PRKCB	KIT	HPRD	empirical	7693453
PRKCB	LMNB1	HPRD, BioGRID	empirical	11901153 8034666
PRKCB	MARCKS	HPRD	empirical	11930178 8557118 7588787
PRKCB	MKI67	HPRD	empirical	10502411
PRKCB	NCAM1	BioGRID	empirical	12743109
PRKCB	NRGN	HPRD	empirical	8080473
PRKCB	PA2G4	HPRD	empirical	11325528
PRKCB	PEBP1	HPRD	empirical	14654844 12551925
PRKCB	PDPK1	HPRD	empirical	11376011
PRKCB	RIPK4	HPRD, BioGRID	empirical	11278382
PRKCB	PRKCB	HPRD, BioGRID	empirical	8327493 19920073
PRKCB	MAPK6	HPRD	empirical	8626698
PRKCB	PTPN11	HPRD	empirical	11781100
PRKCB	RB1	HPRD	empirical	11805327
PRKCB	RGS2	HPRD, BioGRID	empirical	11063746
PRKCB	AFAP1	HPRD, BioGRID	empirical	12134071
PRKCB	RRAD	HPRD	empirical	7876254 9677319
PRKCB	SDC2	HPRD	empirical	9244383
PRKCB	NCF1	HPRD, MINT, BioGRID	empirical	11120743 11145703 8089108 12056906 17069809
PRKCB	BMPR2	HPRD, IntAct, BioGRID	empirical	15188402
PRKCB	SPTAN1	HPRD	empirical	8163551
PRKCB	STXBP1	HPRD	empirical	8631738 12519779 12950453
PRKCB	BTK	HPRD, BioGRID	empirical	11598012 12679936
PRKCB	TIAM1	BioGRID	empirical	10212259
PRKCB	TOP2A	HPRD	empirical	7499337 12569090
PRKCB	UBC	BioGRID	empirical	16954220 17893151
PRKCB	VTN	HPRD	empirical	9030777
PRKCB	YWHAB	IntAct	empirical	16635246
PRKCB	YWHAG	HPRD, BioGRID	empirical	10433554
PRKCB	LST1	HPRD	empirical	15090600
PRKCB	HIST1H3A	BioGRID	empirical	20228790
PRKCB	CARD11	HPRD	empirical	16356855
PRKCB	CASR	HPRD	empirical	9694886 12356761
PRKCB	IKBKG	BioGRID	empirical	20098747
PRKCB	NUMB	HPRD	empirical	17203073
PRKCB	TRIM41	IntAct, BioGRID	empirical	17893151
PRKCB	CD5	HPRD	empirical	11123317
PRKCB	PDLIM7	HPRD	empirical	8940095
PRKCB	CYTH2	HPRD	empirical	10531036
PRKCB	CDK1	BioGRID	empirical	11901153