PRKAR1A

Summary Top Help

Gene Description:

protein kinase, cAMP dependent regulatory, type I, alpha; protein kinase, cAMP-dependent, regulatory, type I, alpha; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

Synonyms:

CNC, CAR, CNC1, PRKAR1A, 1300018C22Rik, PKR1, Prkar1a, PPNAD1, Tse1, Tse-1, ADOHR, PRKAR1, TSE1, RIIA, RIalpha

Orthologs:

Human PRKAR1A (protein-coding), Mouse Prkar1a (protein-coding), Rat Prkar1a (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr17:66508110..66528911 (20.80 kb) View in Genome Browser

(Mouse) NCBIM37 - chr11:109510719..109530970 (20.25 kb) View in Genome Browser

(Rat) RGSC3.4 - chrX:148642200..148642454 (254 bp) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PRKAR1A:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PRKAR1A:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 2

Biocarta: 23

Reactome: 21

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 27

KEGG Network: 2
Apoptosis	Human - 4210	Mouse - 4210	Rat - 4210
Insulin signaling pathway	Human - 4910	Mouse - 4910	Rat - 4910

Biocarta: 23
Actions of Nitric Oxide in the Heart	Human
Activation of cAMP-dependent protein kinase, PKA	Human	Mouse
Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor	Human	Mouse
Attenuation of GPCR Signaling	Human	Mouse
ChREBP regulation by carbohydrates and cAMP	Human	Mouse
Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway	Human	Mouse
GATA3 participate in activating the Th2 cytokine genes expression	Human	Mouse
How Progesterone Initiates the Oocyte Maturation	Human	Mouse
mCalpain and friends in Cell motility	Human	Mouse
Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)	Human
Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation	Human	Mouse
Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells	Human	Mouse
NFAT and Hypertrophy of the heart (Transcription in the broken heart)	Human	Mouse
Nitric Oxide Signaling Pathway	Human	Mouse
Phospholipase C-epsilon pathway	Human	Mouse
Regulation of BAD phosphorylation	Human	Mouse
Regulation of ck1/cdk5 by type 1 glutamate receptors	Human	Mouse
Repression of Pain Sensation by the Transcriptional Regulator DREAM	Human	Mouse
Signaling Pathway from G-Protein Families	Human	Mouse
Sonic Hedgehog (Shh) Pathway	Human	Mouse
Stathmin and breast cancer resistance to antimicrotubule agents	Human	Mouse
Transcription factor CREB and its extracellular signals	Human	Mouse
Transcription Regulation by Methyltransferase of CARM1	Human	Mouse

Reactome: 21
Aquaporin-mediated transport	REACT_23887
Ca-dependent events	REACT_15307
Calmodulin induced events	REACT_9000
CaM pathway	REACT_9053
DARPP-32 events	REACT_15334
Diabetes pathways	REACT_15380
G-protein mediated events	REACT_15526
Glucagon signaling in metabolic regulation	REACT_1665
Integration of energy metabolism	REACT_1505
NGF signalling via TRKA from the plasma membrane	REACT_12056
Opioid Signalling	REACT_15295
PKA activation	REACT_15530
PKA activation in glucagon signalling	REACT_1946
PKA-mediated phosphorylation of CREB	REACT_15497
PLC beta mediated events	REACT_15426
PLC-gamma1 signalling	REACT_12079
Regulation of Insulin Secretion	REACT_18325
Regulation of Insulin Secretion by Glucagon-like Peptide-1	REACT_18274
Regulation of Water Balance by Renal Aquaporins	REACT_24023
Signalling by NGF	REACT_11061
Transmembrane transport of small molecules	REACT_15518

NCI-Nature Pathway Interaction Database: 1

Alpha4 beta1 integrin signaling events

Gene Ontology: 27
Nucleotide binding	GO:0000166
Mesoderm formation	GO:0001707
Regulation of protein phosphorylation	GO:0001932
Protein binding	GO:0005515
Cytosol	GO:0005829
CAMP-dependent protein kinase complex	GO:0005952
Energy reserve metabolic process	GO:0006112
Regulation of transcription from RNA polymerase II promoter	GO:0006357
Water transport	GO:0006833
Signal transduction	GO:0007165
Epidermal growth factor receptor signaling pathway	GO:0007173
Activation of phospholipase C activity	GO:0007202
Blood coagulation	GO:0007596
Fibroblast growth factor receptor signaling pathway	GO:0008543
CAMP-dependent protein kinase regulator activity	GO:0008603
CAMP binding	GO:0030552
Neuromuscular junction	GO:0031594
Ubiquitin protein ligase binding	GO:0031625
Activation of protein kinase A activity	GO:0034199
Intracellular signal transduction	GO:0035556
Protein complex	GO:0043234
Small molecule metabolic process	GO:0044281
Nerve growth factor receptor signaling pathway	GO:0048011
Regulation of catalytic activity	GO:0050790
Regulation of insulin secretion	GO:0050796
Transmembrane transport	GO:0055085
Cellular response to glucagon stimulus	GO:0071377

Publications from PubMed Top Help

Type 1 Diabetes Publications: 2

Publications: 241

Pancreatic ductal and acinar cell neoplasms in Carney complex: a possible new association.
Gaujoux S, Tissier F, Ragazzon B, Rebours V, Saloustros E, Perlemoine K, Vincent-Dejean C, Meurette G, Cassagnau E, Dousset B, Bertagna X, Horvath A, Terris B, Carney JA, Stratakis CA, Bertherat J
J Clin Endocrinol Metab. 2011
PubMed ID: 21900385
Alternative promoter usage and differential expression of multiple transcripts of mouse Prkar1a gene.
Banday AR, Azim S, Tabish M
Mol Cell Biochem. 2011
PubMed ID: 21638026
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
PRKAR1A is overexpressed and represents a possible therapeutic target in human cholangiocarcinoma.
Loilome W, Juntana S, Namwat N, Bhudhisawasdi V, Puapairoj A, Sripa B, Miwa M, Saya H, Riggins GJ, Yongvanit P
Int J Cancer. 2011
PubMed ID: 20824711
Recurrent PRKAR1A mutation in acrodysostosis with hormone resistance.
Linglart A, Menguy C, Couvineau A, Auzan C, Gunes Y, Cancel M, Motte E, Pinto G, Chanson P, Bougnères P, Clauser E, Silve C
N Engl J Med. 2011
PubMed ID: 21651393
Isoform-specific targeting of PKA to multivesicular bodies.
Day ME, Gaietta GM, Sastri M, Koller A, Mackey MR, Scott JD, Perkins GA, Ellisman MH, Taylor SS
J Cell Biol. 2011
PubMed ID: 21502359
Control of PKA stability and signalling by the RING ligase praja2.
Lignitto L, Carlucci A, Sepe M, Stefan E, Cuomo O, Nisticò R, Scorziello A, Savoia C, Garbi C, Annunziato L, Feliciello A
Nat Cell Biol. 2011
PubMed ID: 21423175
Cell-type specific expression of a dominant negative PKA mutation in mice.
Willis BS, Niswender CM, Su T, Amieux PS, McKnight GS
PLoS One. 2011
PubMed ID: 21533282
The regulatory subunit of PKA-I remains partially structured and undergoes β-aggregation upon thermal denaturation.
Dao KK, Pey AL, Gjerde AU, Teigen K, Byeon IJ, Døskeland SO, Gronenborn AM, Martinez A
PLoS One. 2011
PubMed ID: 21394209
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim.
Moujalled D, Weston R, Anderton H, Ninnis R, Goel P, Coley A, Huang DC, Wu L, Strasser A, Puthalakath H
EMBO Rep. 2011
PubMed ID: 21151042
Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors.
Almeida MQ, Tsang KM, Cheadle C, Watkins T, Grivel JC, Nesterova M, Goldbach-Mansky R, Stratakis CA
Hum Mol Genet. 2011
PubMed ID: 20940146
A human MAP kinase interactome.
Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
Nat Methods. 2010
PubMed ID: 20936779
Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function.
Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor SS, Roth DM
J Biol Chem. 2010
PubMed ID: 20581396
Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice.
Molyneux SD, Di Grappa MA, Beristain AG, McKee TD, Wai DH, Paderova J, Kashyap M, Hu P, Maiuri T, Narala SR, Stambolic V, Squire J, Penninger J, Sanchez O, Triche TJ, Wood GA, Kirschner LS, Khokha R
J Clin Invest. 2010
PubMed ID: 20697156
Rb regulates fate choice and lineage commitment in vivo.
Calo E, Quintero-Estades JA, Danielian PS, Nedelcu S, Berman SD, Lees JA
Nature. 2010
PubMed ID: 20686481
Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
Xu G, Paige JS, Jaffrey SR
Nat Biotechnol. 2010
PubMed ID: 20639865
Neural crest-specific loss of Prkar1a causes perinatal lethality resulting from defects in intramembranous ossification.
Jones GN, Pringle DR, Yin Z, Carlton MM, Powell KA, Weinstein MB, Toribio RE, La Perle KM, Kirschner LS
Mol Endocrinol. 2010
PubMed ID: 20534695
Network organization of the human autophagy system.
Behrends C, Sowa ME, Gygi SP, Harper JW
Nature. 2010
PubMed ID: 20562859
Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.
Tsang KM, Starost MF, Nesterova M, Boikos SA, Watkins T, Almeida MQ, Harran M, Li A, Collins MT, Cheadle C, Mertz EL, Leikin S, Kirschner LS, Robey P, Stratakis CA
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20421483
Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling.
Santos NC, Kim KH
Endocrinology. 2010
PubMed ID: 20215566
Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR.
Byeon IJ, Dao KK, Jung J, Keen J, Leiros I, Døskeland SO, Martinez A, Gronenborn AM
J Biol Chem. 2010
PubMed ID: 20197278
Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling.
Almeida MQ, Muchow M, Boikos S, Bauer AJ, Griffin KJ, Tsang KM, Cheadle C, Watkins T, Wen F, Starost MF, Bossis I, Nesterova M, Stratakis CA
Hum Mol Genet. 2010
PubMed ID: 20080939
Biological Pathway-Based Genome-Wide Association Analysis Identified the Vasoactive Intestinal Peptide (VIP) Pathway Important for Obesity.
Liu YJ, Guo YF, Zhang LS, Pei YF, Yu N, Yu P, Papasian CJ, Deng HW
Obesity (Silver Spring). 2010
PubMed ID: 20379146
Mutations and polymorphisms in the gene encoding regulatory subunit type 1-alpha of protein kinase A (PRKAR1A): an update.
Horvath A, Bertherat J, Groussin L, Guillaud-Bataille M, Tsang K, Cazabat L, Libé R, Remmers E, René-Corail F, Faucz FR, Clauser E, Calender A, Bertagna X, Carney JA, Stratakis CA
Hum Mutat. 2010
PubMed ID: 20358582
Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner.
Fiedler SE, Schillace RV, Daniels CJ, Andrews SF, Carr DW
FEBS Lett. 2010
PubMed ID: 20138877
p90 ribosomal S6 kinase 1 (RSK1) and the catalytic subunit of protein kinase A (PKA) compete for binding the pseudosubstrate region of PKAR1alpha: role in the regulation of PKA and RSK1 activities.
Gao X, Chaturvedi D, Patel TB
J Biol Chem. 2010
PubMed ID: 20048145
A novel PRKAR1A mutation associated with primary pigmented nodular adrenocortical disease and the Carney complex.
Peck MC, Visser BC, Norton JA, Pasche L, Katznelson L
Endocr Pract. 2010
PubMed ID: 19833579
The role of germline AIP, MEN1, PRKAR1A, CDKN1B and CDKN2C mutations in causing pituitary adenomas in a large cohort of children, adolescents, and patients with genetic syndromes.
Stratakis CA, Tichomirowa MA, Boikos S, Azevedo MF, Lodish M, Martari M, Verma S, Daly AF, Raygada M, Keil MF, Papademetriou J, Drori-Herishanu L, Horvath A, Tsang KM, Nesterova M, Franklin S, Vanbellinghen JF, Bours V, Salvatori R, Beckers A
Clin Genet. 2010
PubMed ID: 20507346
Myosin Va cooperates with PKA RIalpha to mediate maintenance of the endplate in vivo.
Röder IV, Choi KR, Reischl M, Petersen Y, Diefenbacher ME, Zaccolo M, Pozzan T, Rudolf R
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133847
Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}.
Qiu JJ, Lu X, Zeisig BB, Ma Z, Cai X, Chen S, Gronemeyer H, Tweardy DJ, So CW, Dong S
Blood. 2010
PubMed ID: 19965660
Interaction of the regulatory subunit of the cAMP-dependent protein kinase with PATZ1 (ZNF278).
Yang WL, Ravatn R, Kudoh K, Alabanza L, Chin KV
Biochem Biophys Res Commun. 2010
PubMed ID: 20026299
Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice.
Sahut-Barnola I, de Joussineau C, Val P, Lambert-Langlais S, Damon C, Lefrançois-Martinez AM, Pointud JC, Marceau G, Sapin V, Tissier F, Ragazzon B, Bertherat J, Kirschner LS, Stratakis CA, Martinez A
PLoS Genet. 2010
PubMed ID: 20548949
Familial isolated primary pigmented nodular adrenocortical disease associated with a novel low penetrance PRKAR1A gene splice site mutation.
Storr HL, Metherell LA, Dias R, Savage MO, Rasmussen AK, Clark AJ, Main KM
Horm Res Paediatr. 2010
PubMed ID: 20190548
Association of the M1V PRKAR1A mutation with primary pigmented nodular adrenocortical disease in two large families.
Pereira AM, Hes FJ, Horvath A, Woortman S, Greene E, Bimpaki E, Alatsatianos A, Boikos S, Smit JW, Romijn JA, Nesterova M, Stratakis CA
J Clin Endocrinol Metab. 2010
PubMed ID: 19915019
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.
Crawford NP, Yang H, Mattaini KR, Hunter KW
J Biol Chem. 2009
PubMed ID: 19710015
Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls.
Shelton RC, Hal Manier D, Lewis DA
Int J Neuropsychopharmacol. 2009
PubMed ID: 19573263
Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells.
Ragazzon B, Cazabat L, Rizk-Rabin M, Assie G, Groussin L, Fierrard H, Perlemoine K, Martinez A, Bertherat J
Cancer Res. 2009
PubMed ID: 19738044
The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, Pita G, Milne R, Maravall J, Ramos I, Andía V, Rodríguez-Poyo P, Jara-Albarrán A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Picó A, Pomares F, Giménez G, López-Mondéjar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodríguez-Antona C, González-Neira A, Matías-Guiu X, Santisteban P, Robledo M
PLoS Genet. 2009
PubMed ID: 19730683
The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function.
Chaturvedi D, Cohen MS, Taunton J, Patel TB
J Biol Chem. 2009
PubMed ID: 19570980
Regulatory subunit I-controlled protein kinase A activity is required for apical bile canalicular lumen development in hepatocytes.
Wojtal KA, Diskar M, Herberg FW, Hoekstra D, van Ijzendoorn SC
J Biol Chem. 2009
PubMed ID: 19465483
Abnormalities of cAMP signaling are present in adrenocortical lesions associated with ACTH-independent Cushing syndrome despite the absence of mutations in known genes.
Bimpaki EI, Nesterova M, Stratakis CA
Eur J Endocrinol. 2009
PubMed ID: 19429701
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
Analysis of GNAS1 and PRKAR1A gene mutations in human cardiac myxomas not associated with multiple endocrine disorders.
Mantovani G, Bondioni S, Corbetta S, Menicanti L, Rubino B, Peverelli E, Labarile P, Dall'Asta C, Ambrosi B, Beck-Peccoz P, Lania AG, Spada A
J Endocrinol Invest. 2009
PubMed ID: 19494712
Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1.
Nadella KS, Saji M, Jacob NK, Pavel E, Ringel MD, Kirschner LS
EMBO Rep. 2009
PubMed ID: 19424295
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Mutations in regulatory subunit type 1A of cyclic adenosine 5'-monophosphate-dependent protein kinase (PRKAR1A): phenotype analysis in 353 patients and 80 different genotypes.
Bertherat J, Horvath A, Groussin L, Grabar S, Boikos S, Cazabat L, Libe R, René-Corail F, Stergiopoulos S, Bourdeau I, Bei T, Clauser E, Calender A, Kirschner LS, Bertagna X, Carney JA, Stratakis CA
J Clin Endocrinol Metab. 2009
PubMed ID: 19293268
Subcellular dynamics of type II PKA in neurons.
Zhong H, Sia GM, Sato TR, Gray NW, Mao T, Khuchua Z, Huganir RL, Svoboda K
Neuron. 2009
PubMed ID: 19447092
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
Calvo SE, Pagliarini DJ, Mootha VK
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19372376
PKA microdomain organisation and cAMP handling in healthy and dystrophic muscle in vivo.
Röder IV, Lissandron V, Martin J, Petersen Y, Di Benedetto G, Zaccolo M, Rudolf R
Cell Signal. 2009
PubMed ID: 19263518
Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ
Mol Cell Proteomics. 2009
PubMed ID: 19131326
Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination.
Vuong BQ, Lee M, Kabir S, Irimia C, Macchiarulo S, McKnight GS, Chaudhuri J
Nat Immunol. 2009
PubMed ID: 19234474
Alpha/beta-tubulin are A kinase anchor proteins for type I PKA in neurons.
Kurosu T, Hernández AI, Wolk J, Liu J, Schwartz JH
Brain Res. 2009
PubMed ID: 19056362
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
An empirical framework for binary interactome mapping.
Venkatesan K, Rual JF, Vazquez A, Stelzl U, Lemmens I, Hirozane-Kishikawa T, Hao T, Zenkner M, Xin X, Goh KI, Yildirim MA, Simonis N, Heinzmann K, Gebreab F, Sahalie JM, Cevik S, Simon C, de Smet AS, Dann E, Smolyar A, Vinayagam A, Yu H, Szeto D, Borick H, Dricot A, Klitgord N, Murray RR, Lin C, Lalowski M, Timm J, Rau K, Boone C, Braun P, Cusick ME, Roth FP, Hill DE, Tavernier J, Wanker EE, Barabási AL, Vidal M
Nat Methods. 2009
PubMed ID: 19060904
Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.
Wang B, Malik R, Nigg EA, Körner R
Anal Chem. 2008
PubMed ID: 19007248
Protein kinase A-mediated gating of neuregulin-dependent ErbB2-ErbB3 activation underlies the synergistic action of cAMP on Schwann cell proliferation.
Monje PV, Athauda G, Wood PM
J Biol Chem. 2008
PubMed ID: 18799465
Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
Carrascal M, Ovelleiro D, Casas V, Gay M, Abian J
J Proteome Res. 2008
PubMed ID: 19367720
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production.
Jones GN, Tep C, Towns WH, Mihai G, Tonks ID, Kay GF, Schmalbrock PM, Stemmer-Rachamimov AO, Yoon SO, Kirschner LS
Neoplasia. 2008
PubMed ID: 18953430
Case report of familial Carney complex due to novel frameshift mutation c.597del C (p.Phe200LeufsX6) in PRKAR1A.
Sasaki A, Horikawa Y, Suwa T, Enya M, Kawachi S, Takeda J
Mol Genet Metab. 2008
PubMed ID: 18760947
A novel PRKAR1A mutation associated with hepatocellular carcinoma in a young patient and a variable Carney complex phenotype in affected subjects in older generations.
Gennari M, Stratakis CA, Hovarth A, Pirazzoli P, Cicognani A
Clin Endocrinol (Oxf). 2008
PubMed ID: 18445140
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors.
Gaujoux S, Tissier F, Groussin L, Libé R, Ragazzon B, Launay P, Audebourg A, Dousset B, Bertagna X, Bertherat J
J Clin Endocrinol Metab. 2008
PubMed ID: 18647815
Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.
Zhou H, Ye M, Dong J, Han G, Jiang X, Wu R, Zou H
J Proteome Res. 2008
PubMed ID: 18630941
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Anti-apoptotic action of Wnt5a in dermal fibroblasts is mediated by the PKA signaling pathways.
Torii K, Nishizawa K, Kawasaki A, Yamashita Y, Katada M, Ito M, Nishimoto I, Terashita K, Aiso S, Matsuoka M
Cell Signal. 2008
PubMed ID: 18407462
Protein kinase A subunit expression is altered in Bloom syndrome fibroblasts and the BLM protein is increased in adrenocortical hyperplasias: inverse findings for BLM and PRKAR1A.
Heyerdahl SL, Boikos S, Horvath A, Giatzakis C, Bossis I, Stratakis CA
Horm Metab Res. 2008
PubMed ID: 18401830
Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.
Meoli E, Bossis I, Cazabat L, Mavrakis M, Horvath A, Stergiopoulos S, Shiferaw ML, Fumey G, Perlemoine K, Muchow M, Robinson-White A, Weinberg F, Nesterova M, Patronas Y, Groussin L, Bertherat J, Stratakis CA
Cancer Res. 2008
PubMed ID: 18451138
In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay.
Greene EL, Horvath AD, Nesterova M, Giatzakis C, Bossis I, Stratakis CA
Hum Mutat. 2008
PubMed ID: 18241045
Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition.
Nadella KS, Jones GN, Trimboli A, Stratakis CA, Leone G, Kirschner LS
Cancer Res. 2008
PubMed ID: 18413734
Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
Han G, Ye M, Zhou H, Jiang X, Feng S, Jiang X, Tian R, Wan D, Zou H, Gu J
Proteomics. 2008
PubMed ID: 18318008
High expression of PKA regulatory subunit 1A protein is related to proliferation of human melanoma cells.
Mantovani G, Bondioni S, Lania AG, Rodolfo M, Peverelli E, Polentarutti N, Veliz Rodriguez T, Ferrero S, Bosari S, Beck-Peccoz P, Spada A
Oncogene. 2008
PubMed ID: 17906691
Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.
Yin Z, Jones GN, Towns WH, Zhang X, Abel ED, Binkley PF, Jarjoura D, Kirschner LS
Circulation. 2008
PubMed ID: 18316483
An immortalized human cell line bearing a PRKAR1A-inactivating mutation: effects of overexpression of the wild-type Allele and other protein kinase A subunits.
Nesterova M, Bossis I, Wen F, Horvath A, Matyakhina L, Stratakis CA
J Clin Endocrinol Metab. 2008
PubMed ID: 18056771
Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis.
Yin Z, Williams-Simons L, Parlow AF, Asa S, Kirschner LS
Mol Endocrinol. 2008
PubMed ID: 17975024
Mutation of Prkar1a causes osteoblast neoplasia driven by dysregulation of protein kinase A.
Pavel E, Nadella K, Towns WH, Kirschner LS
Mol Endocrinol. 2008
PubMed ID: 17932105
Large deletions of the PRKAR1A gene in Carney complex.
Horvath A, Bossis I, Giatzakis C, Levine E, Weinberg F, Meoli E, Robinson-White A, Siegel J, Soni P, Groussin L, Matyakhina L, Verma S, Remmers E, Nesterova M, Carney JA, Bertherat J, Stratakis CA
Clin Cancer Res. 2008
PubMed ID: 18223213
Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.
Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y
Anal Sci. 2008
PubMed ID: 18187866
Different expression of protein kinase A (PKA) regulatory subunits in cortisol-secreting adrenocortical tumors: relationship with cell proliferation.
Mantovani G, Lania AG, Bondioni S, Peverelli E, Pedroni C, Ferrero S, Pellegrini C, Vicentini L, Arnaldi G, Bosari S, Beck-Peccoz P, Spada A
Exp Cell Res. 2008
PubMed ID: 17904549
Loss of expression of protein kinase a regulatory subunit 1alpha in pigmented epithelioid melanocytoma but not in melanoma or other melanocytic lesions.
Zembowicz A, Knoepp SM, Bei T, Stergiopoulos S, Eng C, Mihm MC, Stratakis CA
Am J Surg Pathol. 2007
PubMed ID: 18059235
Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells.
Martin BR, Deerinck TJ, Ellisman MH, Taylor SS, Tsien RY
Chem Biol. 2007
PubMed ID: 17884635
Association of dystrobrevin and regulatory subunit of protein kinase A: a new role for dystrobrevin as a scaffold for signaling proteins.
Ceccarini M, Grasso M, Veroni C, Gambara G, Artegiani B, Macchia G, Ramoni C, Torreri P, Mallozzi C, Petrucci TC, Macioce P
J Mol Biol. 2007
PubMed ID: 17610895
Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins.
Lim CJ, Han J, Yousefi N, Ma Y, Amieux PS, McKnight GS, Taylor SS, Ginsberg MH
Nat Cell Biol. 2007
PubMed ID: 17369818
Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.
Molina H, Horn DM, Tang N, Mathivanan S, Pandey A
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17287340
Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.
Dai J, Jin WH, Sheng QH, Shieh CH, Wu JR, Zeng R
J Proteome Res. 2007
PubMed ID: 17203969
Genetic alterations in thyroid cancer: the role of mouse models.
Knostman KA, Jhiang SM, Capen CC
Vet Pathol. 2007
PubMed ID: 17197619
Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis.
Liu J, Rone MB, Papadopoulos V
J Biol Chem. 2006
PubMed ID: 17050526
Will diverse Tat interactions lead to novel antiretroviral drug targets?
Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L
Curr Drug Targets. 2006
PubMed ID: 17168834
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
PRKAR1A inactivation leads to increased proliferation and decreased apoptosis in human B lymphocytes.
Robinson-White AJ, Leitner WW, Aleem E, Kaldis P, Bossis I, Stratakis CA
Cancer Res. 2006
PubMed ID: 17079485
Knockdown of the cAMP-dependent protein kinase (PKA) Type Ialpha regulatory subunit in mouse oocytes disrupts meiotic arrest and results in meiotic spindle defects.
Duncan FE, Moss SB, Williams CJ
Dev Dyn. 2006
PubMed ID: 16937372
Depletion of type IA regulatory subunit (RIalpha) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency.
Mavrakis M, Lippincott-Schwartz J, Stratakis CA, Bossis I
Hum Mol Genet. 2006
PubMed ID: 16963469
Haploinsufficiency at the protein kinase A RI alpha gene locus leads to fertility defects in male mice and men.
Burton KA, McDermott DA, Wilkes D, Poulsen MN, Nolan MA, Goldstein M, Basson CT, McKnight GS
Mol Endocrinol. 2006
PubMed ID: 16728532
Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition.
Dao KK, Teigen K, Kopperud R, Hodneland E, Schwede F, Christensen AE, Martinez A, Døskeland SO
J Biol Chem. 2006
PubMed ID: 16728394
Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor.
Carlson CR, Lygren B, Berge T, Hoshi N, Wong W, Taskén K, Scott JD
J Biol Chem. 2006
PubMed ID: 16728392
Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation.
Glesne D, Huberman E
Oncogene. 2006
PubMed ID: 16491121
An active protein kinase A (PKA) is involved in meiotic arrest of rat growing oocytes.
Kovo M, Kandli-Cohen M, Ben-Haim M, Galiani D, Carr DW, Dekel N
Reproduction. 2006
PubMed ID: 16816331
Comprehensive identification of phosphorylation sites in postsynaptic density preparations.
Trinidad JC, Specht CG, Thalhammer A, Schoepfer R, Burlingame AL
Mol Cell Proteomics. 2006
PubMed ID: 16452087
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Phosphorylation of RIalpha by cyclin-dependent kinase CDK 2/cyclin E modulates the dissociation of the RIalpha-RFC40 complex.
Gupte RS, Traganos F, Darzynkiewicz Z, Lee MY
Cell Cycle. 2006
PubMed ID: 16582606
Inhibition of protein kinase A in murine enteric neurons causes lethal intestinal pseudo-obstruction.
Howe DG, Clarke CM, Yan H, Willis BS, Schneider DA, McKnight GS, Kapur RP
J Neurobiol. 2006
PubMed ID: 16329126
Inherited disposition to cardiac myxoma development.
Wilkes D, Charitakis K, Basson CT
Nat Rev Cancer. 2006
PubMed ID: 16491075
Growth hormone-secreting tumors: genetic aspects and data from animal models.
Lytras A, Tolis G
Neuroendocrinology. 2006
PubMed ID: 17047380
PRKAR1A mutations in primary pigmented nodular adrenocortical disease.
Cazabat L, Ragazzon B, Groussin L, Bertherat J
Pituitary. 2006
PubMed ID: 17036196
Dynamic binding of PKA regulatory subunit RI alpha.
Gullingsrud J, Kim C, Taylor SS, McCammon JA
Structure. 2006
PubMed ID: 16407073
Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).
Foster LJ, Rudich A, Talior I, Patel N, Huang X, Furtado LM, Bilan PJ, Mann M, Klip A
J Proteome Res. 2006
PubMed ID: 16396496
Chemoprevention with protein kinase A RIalpha antisense in DMBA-mammary carcinogenesis.
Nesterova MV, Cho-Chung YS
Ann N Y Acad Sci. 2005
PubMed ID: 16394142
Tumor reversion: protein kinase A isozyme switching.
Cho-Chung YS, Nesterova MV
Ann N Y Acad Sci. 2005
PubMed ID: 16394127
Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding.
Vigil D, Blumenthal DK, Taylor SS, Trewhella J
J Biol Chem. 2005
PubMed ID: 16109722
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
PRKAR1A gene mutation in patients with cardiac myxoma.
Mabuchi T, Shimizu M, Ino H, Yamguchi M, Terai H, Fujino N, Nagata M, Sakata K, Inoue M, Yoneda T, Mabuchi H
Int J Cardiol. 2005
PubMed ID: 15982496
A Japanese case of familial cardiac myxoma associated with a mutation of the PRKAR1alpha gene.
Kojima S, Sumiyoshi M, Watanabe Y, Suwa S, Matsumoto M, Nakata Y, Daida H
Intern Med. 2005
PubMed ID: 16020889
A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues.
Kirschner LS, Kusewitt DF, Matyakhina L, Towns WH, Carney JA, Westphal H, Stratakis CA
Cancer Res. 2005
PubMed ID: 15930266
RIalpha influences cellular proliferation in cancer cells by transporting RFC40 into the nucleus.
Gupte RS, Pozarowski P, Grabarek J, Traganos F, Darzynkiewicz Z, Lee MY
Cancer Biol Ther. 2005
PubMed ID: 15846072
Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA.
Kim C, Xuong NH, Taylor SS
Science. 2005
PubMed ID: 15692043
The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival.
Gupte RS, Weng Y, Liu L, Lee MY
Cell Cycle. 2005
PubMed ID: 15655353
Proliferation of transformed somatotroph cells related to low or absent expression of protein kinase a regulatory subunit 1A protein.
Lania AG, Mantovani G, Ferrero S, Pellegrini C, Bondioni S, Peverelli E, Braidotti P, Locatelli M, Zavanone ML, Ferrante E, Bosari S, Beck-Peccoz P, Spada A
Cancer Res. 2004
PubMed ID: 15604292
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.
Griffin KJ, Kirschner LS, Matyakhina L, Stergiopoulos SG, Robinson-White A, Lenherr SM, Weinberg FD, Claflin ES, Batista D, Bourdeau I, Voutetakis A, Sandrini F, Meoli EM, Bauer AJ, Cho-Chung YS, Bornstein SR, Carney JA, Stratakis CA
J Med Genet. 2004
PubMed ID: 15591278
T cell receptor induced intracellular redistribution of type I protein kinase A.
Zhou W, Vergara L, König R
Immunology. 2004
PubMed ID: 15554923
PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching.
Martin NP, Whalen EJ, Zamah MA, Pierce KL, Lefkowitz RJ
Cell Signal. 2004
PubMed ID: 15381255
Minireview: PRKAR1A: normal and abnormal functions.
Bossis I, Stratakis CA
Endocrinology. 2004
PubMed ID: 15331577
Phosphoproteomic analysis of the developing mouse brain.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP
Mol Cell Proteomics. 2004
PubMed ID: 15345747
Fos-related antigen 2 controls protein kinase A-induced CCAAT/enhancer-binding protein beta expression in osteoblasts.
Chang W, Rewari A, Centrella M, McCarthy TL
J Biol Chem. 2004
PubMed ID: 15299028
cAMP-dependent protein kinase type I regulates ethanol-induced cAMP response element-mediated gene expression via activation of CREB-binding protein and inhibition of MAPK.
Constantinescu A, Wu M, Asher O, Diamond I
J Biol Chem. 2004
PubMed ID: 15299023
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice.
Veugelers M, Wilkes D, Burton K, McDermott DA, Song Y, Goldstein MM, La Perle K, Vaughan CJ, O'Hagan A, Bennett KR, Meyer BJ, Legius E, Karttunen M, Norio R, Kaariainen H, Lavyne M, Neau JP, Richter G, Kirali K, Farnsworth A, Stapleton K, Morelli P, Takanashi Y, Bamforth JS, Eitelberger F, Noszian I, Manfroi W, Powers J, Mochizuki Y, Imai T, Ko GT, Driscoll DA, Goldmuntz E, Edelberg JM, Collins A, Eccles D, Irvine AD, McKnight GS, Basson CT
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15371594
Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.
Nesterova MV, Cho-Chung YS
Clin Cancer Res. 2004
PubMed ID: 15240549
Functional proteomics mapping of a human signaling pathway.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM
Genome Res. 2004
PubMed ID: 15231748
Regional variations in the localization of insoluble kinase A regulatory isoforms during rodent brain development.
Mucignat-Caretta C, Caretta A
J Chem Neuroanat. 2004
PubMed ID: 15183205
Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization.
Powles N, Babbs C, Ficker M, Schimmang T, Maconochie M
Dev Biol. 2004
PubMed ID: 15031102
Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex.
Welting TJ, van Venrooij WJ, Pruijn GJ
Nucleic Acids Res. 2004
PubMed ID: 15096576
Localized effects of cAMP mediated by distinct routes of protein kinase A.
Taskén K, Aandahl EM
Physiol Rev. 2004
PubMed ID: 14715913
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling.
Masci AM, Galgani M, Cassano S, De Simone S, Gallo A, De Rosa V, Zappacosta S, Racioppi L
J Leukoc Biol. 2003
PubMed ID: 12972513
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A.
Grönholm M, Vossebein L, Carlson CR, Kuja-Panula J, Teesalu T, Alfthan K, Vaheri A, Rauvala H, Herberg FW, Taskén K, Carpén O
J Biol Chem. 2003
PubMed ID: 12896975
Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity.
Bertherat J, Groussin L, Sandrini F, Matyakhina L, Bei T, Stergiopoulos S, Papageorgiou T, Bourdeau I, Kirschner LS, Vincent-Dejean C, Perlemoine K, Gicquel C, Bertagna X, Stratakis CA
Cancer Res. 2003
PubMed ID: 14500362
GABAB receptor transduction mechanisms, and cross-talk between protein kinases A and C, in GABAergic terminals synapsing onto neurons of the rat nucleus basalis of Meynert.
Kubota H, Katsurabayashi S, Moorhouse AJ, Murakami N, Koga H, Akaike N
J Physiol. 2003
PubMed ID: 12815184
Human tumors associated with Carney complex and germline PRKAR1A mutations: a protein kinase A disease!
Stergiopoulos SG, Stratakis CA
FEBS Lett. 2003
PubMed ID: 12829237
Protein kinase-A activity in PRKAR1A-mutant cells, and regulation of mitogen-activated protein kinases ERK1/2.
Robinson-White A, Hundley TR, Shiferaw M, Bertherat J, Sandrini F, Stratakis CA
Hum Mol Genet. 2003
PubMed ID: 12812976
AKAP7gamma is a nuclear RI-binding AKAP.
Brown RL, August SL, Williams CJ, Moss SB
Biochem Biophys Res Commun. 2003
PubMed ID: 12804576
Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency--involvement of protein kinase A type I.
Holm AM, Aukrust P, Aandahl EM, Müller F, Taskén K, Frøland SS
J Immunol. 2003
PubMed ID: 12759461
A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum.
Brown PR, Miki K, Harper DB, Eddy EM
Biol Reprod. 2003
PubMed ID: 12606363
Cyclic AMP-dependent protein kinase A and CREB are involved in neuregulin-induced synapse-specific expression of acetylcholine receptor gene.
Kang BH, Jo I, Eun SY, Jo SA
Biochem Biophys Res Commun. 2003
PubMed ID: 12727221
Genetic testing of the family with a Carney-complex member leads to successful early removal of an asymptomatic atrial myxoma in the mother of the patient.
Aspres N, Bleasel NR, Stapleton KM
Australas J Dermatol. 2003
PubMed ID: 12752185
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J
Nat Biotechnol. 2003
PubMed ID: 12665801
Glucagon and regulation of glucose metabolism.
Jiang G, Zhang BB
Am J Physiol Endocrinol Metab. 2003
PubMed ID: 12626323
A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system.
Carlson CR, Ruppelt A, Taskén K
J Mol Biol. 2003
PubMed ID: 12634056
Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).
Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12571360
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Intracellular targeting of protein kinases and phosphatases.
Alto N, Carlisle Michel JJ, Dodge KL, Langeberg LK, Scott JD
Diabetes. 2002
PubMed ID: 12475780
PRKAR1A, one of the Carney complex genes, and its locus (17q22-24) are rarely altered in pituitary tumours outside the Carney complex.
Sandrini F, Kirschner LS, Bei T, Farmakidis C, Yasufuku-Takano J, Takano K, Prezant TR, Marx SJ, Farrell WE, Clayton RN, Groussin L, Bertherat J, Stratakis CA
J Med Genet. 2002
PubMed ID: 12471216
Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology:
Groussin L, Kirschner LS, Vincent-Dejean C, Perlemoine K, Jullian E, Delemer B, Zacharieva S, Pignatelli D, Carney JA, Luton JP, Bertagna X, Stratakis CA, Bertherat J
Am J Hum Genet. 2002
PubMed ID: 12424709
PBR, StAR, and PKA: partners in cholesterol transport in steroidogenic cells.
Hauet T, Liu J, Li H, Gazouli M, Culty M, Papadopoulos V
Endocr Res. 2002
PubMed ID: 12530641
Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer.
Sandrini F, Matyakhina L, Sarlis NJ, Kirschner LS, Farmakidis C, Gimm O, Stratakis CA
Genes Chromosomes Cancer. 2002
PubMed ID: 12203783
Clustered distribution of cAMP-dependent protein kinase regulatory isoform RI alpha during the development of the rat brain.
Mucignat-Caretta C, Caretta A
J Comp Neurol. 2002
PubMed ID: 12210127
Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease.
Groussin L, Jullian E, Perlemoine K, Louvel A, Leheup B, Luton JP, Bertagna X, Bertherat J
J Clin Endocrinol Metab. 2002
PubMed ID: 12213893
Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo.
Amieux PS, Howe DG, Knickerbocker H, Lee DC, Su T, Laszlo GS, Idzerda RL, McKnight GS
J Biol Chem. 2002
PubMed ID: 12004056
Expression and modification of PKA and AKAPs during meiosis in rat oocytes.
Kovo M, Schillace RV, Galiani D, Josefsberg LB, Carr DW, Dekel N
Mol Cell Endocrinol. 2002
PubMed ID: 12088872
Cyclic AMP-dependent signaling aberrations in macronodular adrenal disease.
Bourdeau I, Stratakis CA
Ann N Y Acad Sci. 2002
PubMed ID: 12119280
Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit (PRKAR1A) in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas" (Carney complex).
Stratakis CA
Ann N Y Acad Sci. 2002
PubMed ID: 12119264
Formation of inactive cAMP-saturated holoenzyme of cAMP-dependent protein kinase under physiological conditions.
Kopperud R, Christensen AE, Kjarland E, Viste K, Kleivdal H, Døskeland SO
J Biol Chem. 2002
PubMed ID: 11834733
Differential effects of haloperidol and clozapine on [(3)H]cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain.
Dwivedi Y, Rizavi HS, Pandey GN
J Pharmacol Exp Ther. 2002
PubMed ID: 11907174
Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system.
Souza SC, Muliro KV, Liscum L, Lien P, Yamamoto MT, Schaffer JE, Dallal GE, Wang X, Kraemer FB, Obin M, Greenberg AS
J Biol Chem. 2002
PubMed ID: 11751901
Protein kinase A type I: a target for cancer therapy.
Tortora G, Ciardiello F
Clin Cancer Res. 2002
PubMed ID: 11839645
cAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes.
Lazar S, Galiani D, Dekel N
Mol Endocrinol. 2002
PubMed ID: 11818504
Binding of PKA-RIIalpha to the Adenovirus E1A12S oncoprotein correlates with its nuclear translocation and an increase in PKA-dependent promoter activity.
Fax P, Carlson CR, Collas P, Taskén K, Esche H, Brockmann D
Virology. 2001
PubMed ID: 11414803
Muscle-regulated expression and determinants for neuromuscular junctional localization of the mouse RIalpha regulatory subunit of cAMP-dependent protein kinase.
Barradeau S, Imaizumi-Scherrer T, Weiss MC, Faust DM
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11296260
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the carney complex.
Kirschner LS, Sandrini F, Monbo J, Lin JP, Carney JA, Stratakis CA
Hum Mol Genet. 2000
PubMed ID: 11115848
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Unconventional myosin VIIA is a novel A-kinase-anchoring protein.
Küssel-Andermann P, El-Amraoui A, Safieddine S, Hardelin JP, Nouaille S, Camonis J, Petit C
J Biol Chem. 2000
PubMed ID: 10889203
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S
EMBO Rep. 2000
PubMed ID: 11256614
Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and Carney complex.
Casey M, Vaughan CJ, He J, Hatcher CJ, Winter JM, Weremowicz S, Montgomery K, Kucherlapati R, Morton CC, Basson CT
J Clin Invest. 2000
PubMed ID: 10974026
Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex.
Kirschner LS, Carney JA, Pack SD, Taymans SE, Giatzakis C, Cho YS, Cho-Chung YS, Stratakis CA
Nat Genet. 2000
PubMed ID: 10973256
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Alternative 5'-exons of the mouse cAMP-dependent protein kinase subunit RIalpha gene are conserved and expressed in both a ubiquitous and tissue-restricted fashion.
Barradeau S, Imaizumi-Scherrer T, Weiss MC, Faust DM
FEBS Lett. 2000
PubMed ID: 10913627
Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis.
Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K
Dev Biol. 2000
PubMed ID: 10864471
The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1.
Vincent JB, Skaug J, Scherer SW
DNA Res. 2000
PubMed ID: 10907856
Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding.
Herberg FW, Maleszka A, Eide T, Vossebein L, Tasken K
J Mol Biol. 2000
PubMed ID: 10764601
Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development.
Woldeyesus MT, Britsch S, Riethmacher D, Xu L, Sonnenberg-Riethmacher E, Abou-Rebyeh F, Harvey R, Caroni P, Birchmeier C
Genes Dev. 1999
PubMed ID: 10521398
Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes.
Laxminarayana D, Khan IU, Mishra N, Olorenshaw I, Taskén K, Kammer GM
J Immunol. 1999
PubMed ID: 10228048
PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I.
Zimmermann B, Chiorini JA, Ma Y, Kotin RM, Herberg FW
J Biol Chem. 1999
PubMed ID: 10026146
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Identification of tethering domains for protein kinase A type Ialpha regulatory subunits on sperm fibrous sheath protein FSC1.
Miki K, Eddy EM
J Biol Chem. 1998
PubMed ID: 9852104
Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways.
Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F
AIDS Res Hum Retroviruses. 1998
PubMed ID: 9671211
Expression of adenylyl cyclase mRNAs in the denervated and in the developing mouse skeletal muscle.
Suzuki Y, Shen T, Poyard M, Best-Belpomme M, Hanoune J, Defer N
Am J Physiol. 1998
PubMed ID: 9611134
HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.
Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C
Neuroimmunomodulation. 1998
PubMed ID: 9730685
Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts.
Liapi C, Takahashi N, Raynaud F, Evain-Brion D, Anderson WB
J Invest Dermatol. 1998
PubMed ID: 9540970
Dissecting the cooperative reassociation of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Role of Trp-196 in the catalytic subunit.
Gibson RM, Taylor SS
J Biol Chem. 1997
PubMed ID: 9405392
Molecular characterization and in situ localization of a mouse retinal taurine transporter.
Vinnakota S, Qian X, Egal H, Sarthy V, Sarkar HK
J Neurochem. 1997
PubMed ID: 9375654
D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain.
Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9326583
The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.
Chen P, Mayne M, Power C, Nath A
J Biol Chem. 1997
PubMed ID: 9278385
The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.
Swingler S, Gallay P, Camaur D, Song J, Abo A, Trono D
J Virol. 1997
PubMed ID: 9151826
Large-scale concatenation cDNA sequencing.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA
Genome Res. 1997
PubMed ID: 9110174
Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits.
Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS
J Biol Chem. 1997
PubMed ID: 9065479
The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor.
Tortora G, Damiano V, Bianco C, Baldassarre G, Bianco AR, Lanfrancone L, Pelicci PG, Ciardiello F
Oncogene. 1997
PubMed ID: 9050991
Compensatory regulation of RIalpha protein levels in protein kinase A mutant mice.
Amieux PS, Cummings DE, Motamed K, Brandon EP, Wailes LA, Le K, Idzerda RL, McKnight GS
J Biol Chem. 1997
PubMed ID: 9020105
The human gene for the regulatory subunit RI alpha of cyclic adenosine 3', 5'-monophosphate-dependent protein kinase: two distinct promoters provide differential regulation of alternately spliced messenger ribonucleic acids.
Solberg R, Sandberg M, Natarajan V, Torjesen PA, Hansson V, Jahnsen T, Taskén K
Endocrinology. 1997
PubMed ID: 8977401
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha.
Imaizumi-Scherrer T, Faust DM, Bénichou JC, Hellio R, Weiss MC
J Cell Biol. 1996
PubMed ID: 8794865
Sporadic cardiac myxomas and tumors from patients with Carney complex are not associated with activating mutations of the Gs alpha gene.
DeMarco L, Stratakis CA, Boson WL, Jakbovitz O, Carson E, Andrade LM, Amaral VF, Rocha JL, Choursos GP, Nordenskjöld M, Friedman E
Hum Genet. 1996
PubMed ID: 8698339
Mapping of the Prkar1a gene to mouse chromosome 11.
Moskow JJ, Buchberg AM
Mamm Genome. 1996
PubMed ID: 8662216
A "double adaptor" method for improved shotgun library construction.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA
Anal Biochem. 1996
PubMed ID: 8619474
Chromosomal localization of homeobox genes and associated markers on porcine chromosomes 3, 5, 12, 15, 16 and 18: comparative mapping study with human and mouse.
Lahbib-Mansais Y, Yerle M, Pinton P, Gellin J
Mamm Genome. 1996
PubMed ID: 8833235
Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2.
Stratakis CA, Carney JA, Lin JP, Papanicolaou DA, Karl M, Kastner DL, Pras E, Chrousos GP
J Clin Invest. 1996
PubMed ID: 8609225
Patterns of cyclic AMP-dependent protein kinase gene expression during ontogeny of the murine palate.
Greene RM, Lloyd MR, Uberti M, Nugent P, Pisano MM
J Cell Physiol. 1995
PubMed ID: 7775586
HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro.
Hofmann B, Nishanian P, Fan J, Nguyen T, Fahey JL
AIDS. 1994
PubMed ID: 7946090
Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes.
Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V
J Biol Chem. 1993
PubMed ID: 8407966
Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.
Hofmann B, Nishanian P, Nguyen T, Insixiengmay P, Fahey JL
Proc Natl Acad Sci U S A. 1993
PubMed ID: 7688126
Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A.
Bongarzone I, Monzini N, Borrello MG, Carcano C, Ferraresi G, Arighi E, Mondellini P, Della Porta G, Pierotti MA
Mol Cell Biol. 1993
PubMed ID: 7678053
Promoter for the regulatory type I beta subunit of the 3',5'-cyclic adenosine monophosphate-dependent protein kinase directs transgene expression in the central nervous system.
Rogers KV, Boring LF, McKnight GS, Clegg CH
Mol Endocrinol. 1992
PubMed ID: 1448119
Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A.
Jones KW, Shapero MH, Chevrette M, Fournier RE
Cell. 1991
PubMed ID: 1889088
The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-dependent protein kinase.
Boshart M, Weih F, Nichols M, Schütz G
Cell. 1991
PubMed ID: 1832337
HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism.
Hofmann B, Nishanian P, Baldwin RL, Insixiengmay P, Nel A, Fahey JL
J Immunol. 1990
PubMed ID: 1978848
The two mRNA forms for the type I alpha regulatory subunit of cAMP-dependent protein kinase from human testis are due to the use of different polyadenylation site signals.
Sandberg M, Skålhegg B, Jahnsen T
Biochem Biophys Res Commun. 1990
PubMed ID: 2310396
cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.
Taylor SS, Buechler JA, Yonemoto W
Annu Rev Biochem. 1990
PubMed ID: 2165385
Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1.
Lem J, Chin AC, Thayer MJ, Leach RJ, Fournier RE
Proc Natl Acad Sci U S A. 1988
PubMed ID: 2902627
Molecular cloning, cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP-dependent protein kinase from human testis.
Sandberg M, Taskén K, Oyen O, Hansson V, Jahnsen T
Biochem Biophys Res Commun. 1987
PubMed ID: 3426618
Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis.
Scambler P, Oyen O, Wainwright B, Farrall M, Law HY, Estivill X, Sandberg M, Williamson R, Jahnsen T
Am J Hum Genet. 1987
PubMed ID: 3479018
Molecular cloning and cDNA structure of the regulatory subunit of type I cAMP-dependent protein kinase from rat brain.
Kuno T, Ono Y, Hirai M, Hashimoto S, Shuntoh H, Tanaka C
Biochem Biophys Res Commun. 1987
PubMed ID: 3619906
The physical map of Mus musculus chromosome 11 reveals evolutionary relationships with different syntenic groups of genes in Homo sapiens.
Münke M, Francke U
J Mol Evol. 1987
PubMed ID: 3116273
Chromosomal assignment and trans regulation of the tyrosine aminotransferase structural gene in hepatoma hybrid cells.
Peterson TC, Killary AM, Fournier RE
Mol Cell Biol. 1985
PubMed ID: 2874483
HLA-A2 antigen phosphorylation in vitro by cyclic AMP-dependent protein kinase. Sites of phosphorylation and segmentation in class i major histocompatibility complex gene structure.
Guild BC, Strominger JL
J Biol Chem. 1984
PubMed ID: 6333425
A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells.
Killary AM, Fournier RE
Cell. 1984
PubMed ID: 6147198
Phosphorylation of cAMP-dependent protein kinase subunits.
Geahlen RL, Carmichael DF, Hashimoto E, Krebs EG
Adv Enzyme Regul. 1982
PubMed ID: 6287816
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	Human	Mouse	Rat
Entrez Gene	5573	19084	25725
EnsEMBL Gene(s)	ENSG00000108946	ENSMUSG00000020612	N/A
Unigene	Hs.280342	Mm.30039	Rn.10990
Homologene	PRKAR1A	Prkar1a	Prkar1a
OMIM	188830	N/A	N/A
GeneCards	PRKAR1A	N/A	N/A
Beta Cell Genomics	DT.100877957 DT.102835354 DT.302776 DT.92476611 DT.95362652 DT.95362712 DT.99927439 DT.99984295	DT.101181443 DT.101213189 DT.101244388 DT.101248214 DT.101405600 DT.94151093 DT.94217353 DT.99866343	N/A
Reactome	P10644	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	5573	19084	25725

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Interactor	Interactor	Sources	Classification	Pubmed IDs
PRKAR1A	CDH2	IntAct	empirical	20195357
PRKAR1A	HUWE1	IntAct	empirical	20195357
PRKAR1A	COL4A3BP	IntAct	empirical	20195357
PRKAR1A	CDK2	HPRD	empirical	16582606
PRKAR1A	CDK4	HPRD	empirical	16582606
PRKAR1A	MCRS1	IntAct	empirical	17353931
PRKAR1A	ANP32B	IntAct	empirical	20195357
PRKAR1A	ARFGEF2	HPRD	empirical	12571360
PRKAR1A	NPRL2	IntAct	empirical	17353931
PRKAR1A	CAPN11	IntAct	empirical	21988832
PRKAR1A	AKAP11	HPRD	empirical	10864471
PRKAR1A	AKAP10	HPRD, MINT, IntAct	empirical	9326583 16189514
PRKAR1A	GABARAP	IntAct	empirical	20562859
PRKAR1A	GABARAPL2	IntAct	empirical	20562859
PRKAR1A	CHMP4B	IntAct	empirical	20195357
PRKAR1A	COX5B	MIPS	empirical	9760254
PRKAR1A	EGFR	HPRD	empirical	9050991
PRKAR1A	FHL2	MINT, IntAct	empirical	15102471
PRKAR1A	FTSJD2	IntAct	empirical	20195357
PRKAR1A	RPGRIP1L	IntAct	empirical	21565611
PRKAR1A	CRB1	IntAct	empirical	17353931
PRKAR1A	GABARAPL1	IntAct	empirical	20562859
PRKAR1A	XRCC6	IntAct	empirical	20195357
PRKAR1A	GRB2	HPRD	empirical	9050991
PRKAR1A	GRIN1	IntAct	empirical	16635246
PRKAR1A	GRIN2B	IntAct	empirical	16635246
PRKAR1A	PYCARD	HPRD, MINT, IntAct	empirical	16189514
PRKAR1A	BRD7	IntAct	empirical	20195357
PRKAR1A	HIVEP1	IntAct	empirical	21988832
PRKAR1A	HLA-A	HPRD	empirical	6333425
PRKAR1A	TCEAL5	IntAct	empirical	20195357
PRKAR1A	ITGA4	HPRD	empirical	17369818
PRKAR1A	ITGB2	MINT, IntAct	empirical	15102471
PRKAR1A	SMAD2	HPRD, MINT	empirical	15231748
PRKAR1A	MAP1LC3C	IntAct	empirical	20562859
PRKAR1A	MYO7A	HPRD	empirical	10889203
PRKAR1A	PPP1R12A	IntAct	empirical	20195357
PRKAR1A	NCL	IntAct	empirical	20195357
PRKAR1A	PAM	IntAct	empirical	20195357
PRKAR1A	ING4	MINT, IntAct	empirical	15102471
PRKAR1A	PRKACA	HPRD, IntAct, Reactome	empirical	9405392 11834733 17353931 15655353
PRKAR1A	PRPF40A	HPRD, MINT	empirical	15231748
PRKAR1A	PRKACB	IntAct, Reactome	empirical	21880142
PRKAR1A	PRKACG	Reactome	predicted
PRKAR1A	PRKAR1B	HPRD	empirical	12634056 8407966
PRKAR1A	PRKX	HPRD, IntAct	empirical	10026146 16491121
PRKAR1A	YLPM1	MINT, IntAct	empirical	15102471
PRKAR1A	RANBP2	MINT, IntAct	empirical	15102471
PRKAR1A	RFC2	HPRD, IntAct	empirical	15096576 15655353
PRKAR1A	RPS17	IntAct	empirical	20195357
PRKAR1A	SET	IntAct	empirical	20195357
PRKAR1A	SLC2A4	HPRD, MINT, IntAct	empirical	16396496
PRKAR1A	SPTBN1	IntAct	empirical	20195357
PRKAR1A	SSRP1	IntAct	empirical	20195357
PRKAR1A	STXBP1	IntAct	empirical	20195357
PRKAR1A	UBE2I	IntAct	empirical	20936779
PRKAR1A	UQCRB	MINT, IntAct	empirical	15102471
PRKAR1A	PLEKHF2	HPRD, MINT, IntAct	empirical	16189514 19060904
PRKAR1A	SETD7	IntAct	empirical	21988832
PRKAR1A	TAF15	MINT, IntAct	empirical	15102471
PRKAR1A	MAP1LC3B	IntAct	empirical	20562859
PRKAR1A	AKAP1	HPRD, MINT	empirical	10764601 9065479
PRKAR1A	C2orf88	HPRD, MINT, IntAct	empirical	16189514
PRKAR1A	BEX2	IntAct	empirical	20195357
PRKAR1A	AKAP4	HPRD	empirical	9852104
PRKAR1A	CCNE1	HPRD	empirical	16582606
PRKAR1A	UBE2M	IntAct	empirical	17353931
PRKAR1A	AKAP7	HPRD	empirical	12804576
PRKAR1A	SLC25A27	IntAct	empirical	20195357
PRKAR1A	NUAK1	IntAct	empirical	17353931