PRKACA

Summary Top Help

Gene Description:

protein kinase, cAMP dependent, catalytic, alpha; protein kinase, cAMP-dependent, catalytic, alpha

Synonyms:

Pkaca, Prkaca, PRKACA, PKACA, PKCA1, PKCD, PKA, Cs, Cs-PKA

Orthologs:

Human PRKACA (protein-coding), Mouse Prkaca (protein-coding), Rat Prkaca (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr19:14202500..14228574 (267 kb) View in Genome Browser

(Mouse) NCBIM37 - chr8:86496877..86520344 (23.47 kb) View in Genome Browser

(Rat) RGSC3.4 - chr19:25840795..25864786 (23.99 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PRKACA:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PRKACA:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 27

Biocarta: 1

Reactome: 36

NCI-Nature Pathway Interaction Database: 21

Gene Ontology: 55

G2/M transition of mitotic cell cycle	GO:0000086
Nucleotide binding	GO:0000166
Mitotic cell cycle	GO:0000278
Mesoderm formation	GO:0001707
Protein serine/threonine kinase activity	GO:0004674
CAMP-dependent protein kinase activity	GO:0004691
Protein binding	GO:0005515
ATP binding	GO:0005524
Membrane fraction	GO:0005624
Soluble fraction	GO:0005625
Nucleus	GO:0005634
Cytoplasm	GO:0005737
Mitochondrion	GO:0005739
Golgi apparatus	GO:0005794
Centrosome	GO:0005813
Cytosol	GO:0005829
Plasma membrane	GO:0005886
CAMP-dependent protein kinase complex	GO:0005952
Carbohydrate metabolic process	GO:0005975
Glucose metabolic process	GO:0006006
Gluconeogenesis	GO:0006094
Energy reserve metabolic process	GO:0006112
Protein phosphorylation	GO:0006468
Lipid metabolic process	GO:0006629
Water transport	GO:0006833
Signal transduction	GO:0007165
Epidermal growth factor receptor signaling pathway	GO:0007173
Activation of phospholipase C activity	GO:0007202
Intracellular protein kinase cascade	GO:0007243
Blood coagulation	GO:0007596
Fibroblast growth factor receptor signaling pathway	GO:0008543
Peptidyl-serine phosphorylation	GO:0018105
Triglyceride catabolic process	GO:0019433
Protein kinase binding	GO:0019901
Neuromuscular junction	GO:0031594
Ubiquitin protein ligase binding	GO:0031625
Activation of protein kinase A activity	GO:0034199
Regulation of cellular respiration	GO:0043457
Small molecule metabolic process	GO:0044281
Regulation of osteoblast differentiation	GO:0045667
Protein autophosphorylation	GO:0046777
Positive regulation of protein export from nucleus	GO:0046827
Nerve growth factor receptor signaling pathway	GO:0048011
Sperm capacitation	GO:0048240
Perinuclear region of cytoplasm	GO:0048471
Regulation of insulin secretion	GO:0050796
Negative regulation of meiotic cell cycle	GO:0051447
Regulation of synaptic transmission, glutamatergic	GO:0051966
Transmembrane transport	GO:0055085
Regulation of proteasomal protein catabolic process	GO:0061136
Positive regulation of cell cycle arrest	GO:0071158
Cellular response to glucose stimulus	GO:0071333
Cellular response to parathyroid hormone stimulus	GO:0071374
Cellular response to glucagon stimulus	GO:0071377
Regulation of tight junction assembly	GO:2000810

Publications from PubMed Top Help

Type 1 Diabetes Publications: 9

Lower expression of PKAα impairs insulin secretion in islets isolated from low-density lipoprotein receptor (LDLR(-/-)) knockout mice.
Bonfleur ML, Ribeiro RA, Balbo SL, Vanzela EC, Carneiro EM, Franco de Oliveira HC, Boschero AC
Metabolism. 2011
PubMed ID: 21306750
Taurine supplementation: involvement of cholinergic/phospholipase C and protein kinase A pathways in potentiation of insulin secretion and Ca2+ handling in mouse pancreatic islets.
Ribeiro RA, Vanzela EC, Oliveira CA, Bonfleur ML, Boschero AC, Carneiro EM
Br J Nutr. 2010
PubMed ID: 20591207
Noncanonical activation of Akt/protein kinase B in {beta}-cells by the incretin hormone glucose-dependent insulinotropic polypeptide.
Widenmaier SB, Sampaio AV, Underhill TM, McIntosh CH
J Biol Chem. 2009
PubMed ID: 19233842
Vasoactive intestinal peptide inhibits TNF-alpha-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands.
Calafat M, Larocca L, Roca V, Hauk V, Pregi N, Nesse A, Pérez Leirós C
Arthritis Res Ther. 2009
PubMed ID: 19356238
Soybean diet improves insulin secretion through activation of cAMP/PKA pathway in rats.
Veloso RV, Latorraca MQ, Arantes VC, Reis MA, Ferreira F, Boschero AC, Carneiro EM
J Nutr Biochem. 2008
PubMed ID: 18430554
Activation of exchange protein directly activated by cyclic adenosine monophosphate and protein kinase A regulate common and distinct steps in promoting plasma membrane exocytic and granule-to-granule fusions in rat islet beta cells.
Kwan EP, Gao X, Leung YM, Gaisano HY
Pancreas. 2007
PubMed ID: 17895835
Identification of an IQGAP1/AKAP79 complex in beta-cells.
Nauert JB, Rigas JD, Lester LB
J Cell Biochem. 2003
PubMed ID: 12938160
Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis.
Gao Z, Young RA, Trucco MM, Greene SR, Hewlett EL, Matschinsky FM, Wolf BA
Biochem J. 2002
PubMed ID: 12180908
Protein kinase A-dependent phosphorylation of GLUT2 in pancreatic beta cells.
Thorens B, Dériaz N, Bosco D, DeVos A, Pipeleers D, Schuit F, Meda P, Porret A
J Biol Chem. 1996
PubMed ID: 8626492

Publications: 647

The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+).
Gerhart-Hines Z, Dominy JE, Blättler SM, Jedrychowski MP, Banks AS, Lim JH, Chim H, Gygi SP, Puigserver P
Mol Cell. 2011
PubMed ID: 22195961
Mutants of protein kinase A that mimic the ATP-binding site of Aurora kinase.
Pflug A, de Oliveira TM, Bossemeyer D, Engh RA
Biochem J. 2011
PubMed ID: 21774789
Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube.
Tuson M, He M, Anderson KV
Development. 2011
PubMed ID: 22007132
Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease.
Giralt A, Saavedra A, Carretón O, Xifró X, Alberch J, Pérez-Navarro E
Hum Mol Genet. 2011
PubMed ID: 21835884
Myosin binding protein-C slow is a novel substrate for protein kinase A (PKA) and C (PKC) in skeletal muscle.
Ackermann MA, Kontrogianni-Konstantopoulos A
J Proteome Res. 2011
PubMed ID: 21888435
Spatiotemporally regulated protein kinase A activity is a critical regulator of growth factor-stimulated extracellular signal-regulated kinase signaling in PC12 cells.
Herbst KJ, Allen MD, Zhang J
Mol Cell Biol. 2011
PubMed ID: 21807900
Increased interactions between PKA and NF-κB signaling in the hippocampus following loss of cholinergic input.
Lim CS, Hwang YK, Kim D, Cho SH, Bañuelos C, Bizon JL, Han JS
Neuroscience. 2011
PubMed ID: 21723926
Increased expression of the pro-apoptotic protein BIM, a mechanism for cAMP/protein kinase A (PKA)-induced apoptosis of immature T cells.
Zambon AC, Wilderman A, Ho A, Insel PA
J Biol Chem. 2011
PubMed ID: 21808067
Transcriptional control of adrenal steroidogenesis: novel connection between Janus kinase (JAK) 2 protein and protein kinase A (PKA) through stabilization of cAMP response element-binding protein (CREB) transcription factor.
Lefrancois-Martinez AM, Blondet-Trichard A, Binart N, Val P, Chambon C, Sahut-Barnola I, Pointud JC, Martinez A
J Biol Chem. 2011
PubMed ID: 21808064
PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism.
Mao T, Shao M, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Y, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W, Liu Y
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21911379
Prostaglandin E2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activation.
Clasadonte J, Poulain P, Hanchate NK, Corfas G, Ojeda SR, Prevot V
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21896757
Protein kinase A activity at the endoplasmic reticulum surface is responsible for augmentation of human ether-a-go-go-related gene product (HERG).
Sroubek J, McDonald TV
J Biol Chem. 2011
PubMed ID: 21536683
The influence of trout cardiac troponin I and PKA phosphorylation on the Ca2+ affinity of the cardiac troponin complex.
Kirkpatrick KP, Robertson AS, Klaiman JM, Gillis TE
J Exp Biol. 2011
PubMed ID: 21613513
Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells.
Tkachenko E, Sabouri-Ghomi M, Pertz O, Kim C, Gutierrez E, Machacek M, Groisman A, Danuser G, Ginsberg MH
Nat Cell Biol. 2011
PubMed ID: 21572420
Probing cellular protein complexes using single-molecule pull-down.
Jain A, Liu R, Ramani B, Arauz E, Ishitsuka Y, Ragunathan K, Park J, Chen J, Xiang YK, Ha T
Nature. 2011
PubMed ID: 21614075
Protein kinase A activates and phosphorylates RORα4 in vitro and takes part in RORα activation by CaMK-IV.
Ermisch M, Firla B, Steinhilber D
Biochem Biophys Res Commun. 2011
PubMed ID: 21514275
Mice with disrupted type I protein kinase A anchoring in T cells resist retrovirus-induced immunodeficiency.
Mosenden R, Singh P, Cornez I, Heglind M, Ruppelt A, Moutschen M, Enerbäck S, Rahmouni S, Taskén K
J Immunol. 2011
PubMed ID: 21430226
Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease.
Shi J, Qian W, Yin X, Iqbal K, Grundke-Iqbal I, Gu X, Ding F, Gong CX, Liu F
J Biol Chem. 2011
PubMed ID: 21367856
Protein kinase A is central for forward transport of two-pore domain potassium channels K(2P)3.1 and K(2P)9.1.
Mant A, Elliott D, Eyers PA, O'Kelly IM
J Biol Chem. 2011
PubMed ID: 21357689
Protein kinase A phosphorylates and regulates the osteogenic activity of Dlx5.
Han Y, Jin YH, Yum J, Jeong HM, Choi JK, Yeo CY, Lee KY
Biochem Biophys Res Commun. 2011
PubMed ID: 21406180
Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1.
Merrill RA, Dagda RK, Dickey AS, Cribbs JT, Green SH, Usachev YM, Strack S
PLoS Biol. 2011
PubMed ID: 21526220
Control of PKA stability and signalling by the RING ligase praja2.
Lignitto L, Carlucci A, Sepe M, Stefan E, Cuomo O, Nisticò R, Scorziello A, Savoia C, Garbi C, Annunziato L, Feliciello A
Nat Cell Biol. 2011
PubMed ID: 21423175
A CRE that binds CREB and contributes to PKA-dependent regulation of the proximal promoter of human RAB25 gene.
Xue H, Qiao Y, Ni P, Wang J, Chen C, Huang G
Int J Biochem Cell Biol. 2011
PubMed ID: 21075212
Cross-talk between protein kinase A and the MAPK-activated protein kinases RSK1 and MK5.
Kostenko S, Shiryaev A, Dumitriu G, Gerits N, Moens U
J Recept Signal Transduct Res. 2011
PubMed ID: 20849292
The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA.
Vetter MM, Zenn HM, Méndez E, van den Boom H, Herberg FW, Skålhegg BS
BMC Biochem. 2011
PubMed ID: 21812984
Identification of a novel TGFβ/PKA signaling transduceome in mediating control of cell survival and metastasis in colon cancer.
Chowdhury S, Howell GM, Rajput A, Teggart CA, Brattain LE, Weber HR, Chowdhury A, Brattain MG
PLoS One. 2011
PubMed ID: 21559296
Cell-type specific expression of a dominant negative PKA mutation in mice.
Willis BS, Niswender CM, Su T, Amieux PS, McKnight GS
PLoS One. 2011
PubMed ID: 21533282
Fibronectin increases RhoA activity through inhibition of PKA in the human gastric cancer cell line SGC-7901.
Li Y, Chen Y, Tao Y, Wang Y, Chen Y, Xu W
Mol Med Report. 2011
PubMed ID: 21461565
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors.
Almeida MQ, Tsang KM, Cheadle C, Watkins T, Grivel JC, Nesterova M, Goldbach-Mansky R, Stratakis CA
Hum Mol Genet. 2011
PubMed ID: 20940146
Downregulation of the cAMP/PKA pathway in PC12 cells overexpressing NCS-1.
Souza BR, Torres KC, Miranda DM, Motta BS, Caetano FS, Rosa DV, Souza RP, Giovani A, Carneiro DS, Guimarães MM, Martins-Silva C, Reis HJ, Gomez MV, Jeromin A, Romano-Silva MA
Cell Mol Neurobiol. 2011
PubMed ID: 20838877
Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition.
Bodenstine TM, Vaidya KS, Ismail A, Beck BH, Cook LM, Diers AR, Landar A, Welch DR
Cancer Res. 2010
PubMed ID: 21098703
Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradation.
Xie Z, Yang Z, Druey KM
J Mol Cell Biol. 2010
PubMed ID: 20974683
Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade.
Roberts W, Magwenzi S, Aburima A, Naseem KM
Blood. 2010
PubMed ID: 20664056
Dynamics connect substrate recognition to catalysis in protein kinase A.
Masterson LR, Cheng C, Yu T, Tonelli M, Kornev A, Taylor SS, Veglia G
Nat Chem Biol. 2010
PubMed ID: 20890288
Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions.
Pflug A, Rogozina J, Lavogina D, Enkvist E, Uri A, Engh RA, Bossemeyer D
J Mol Biol. 2010
PubMed ID: 20732331
A human MAP kinase interactome.
Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
Nat Methods. 2010
PubMed ID: 20936779
Epinephrine accelerates osteoblastic differentiation by enhancing bone morphogenetic protein signaling through a cAMP/protein kinase A signaling pathway.
Uemura T, Ohta Y, Nakao Y, Manaka T, Nakamura H, Takaoka K
Bone. 2010
PubMed ID: 20637325
Protein kinase A in the pedunculopontine tegmental nucleus of rat contributes to regulation of rapid eye movement sleep.
Datta S, Desarnaud F
J Neurosci. 2010
PubMed ID: 20844122
Status epilepticus alters hippocampal PKAbeta and PKAgamma expression in mice.
Liu JX, Tang YC, Liu Y, Tang FR
Seizure. 2010
PubMed ID: 20630779
Luteinizing hormone receptor-stimulated progesterone production by preovulatory granulosa cells requires protein kinase A-dependent activation/dephosphorylation of the actin dynamizing protein cofilin.
Karlsson AB, Maizels ET, Flynn MP, Jones JC, Shelden EA, Bamburg JR, Hunzicker-Dunn M
Mol Endocrinol. 2010
PubMed ID: 20610540
Dopaminergic D2 receptors activate PKA to inhibit spinal pelvic-urethra reflex in rats.
Wu HC, Chiu CH, Tung KC, Chen GD, Peng HY, Lin TB
Am J Physiol Renal Physiol. 2010
PubMed ID: 20554643
Elevated extracellular calcium increases fibroblast growth factor-2 gene and protein expression levels via a cAMP/PKA dependent pathway in cementoblasts.
Kanaya S, Nemoto E, Ebe Y, Somerman MJ, Shimauchi H
Bone. 2010
PubMed ID: 20542497
PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy.
Ha CH, Kim JY, Zhao J, Wang W, Jhun BS, Wong C, Jin ZG
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20716686
Regulation of placental leptin expression by cyclic adenosine 5'-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathways.
Maymó JL, Pérez Pérez A, Dueñas JL, Calvo JC, Sánchez-Margalet V, Varone CL
Endocrinology. 2010
PubMed ID: 20484458
Beta-adrenergic signals regulate adipogenesis of mouse mesenchymal stem cells via cAMP/PKA pathway.
Li H, Fong C, Chen Y, Cai G, Yang M
Mol Cell Endocrinol. 2010
PubMed ID: 20363288
Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.
Sarma S, Li N, van Oort RJ, Reynolds C, Skapura DG, Wehrens XH
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20615971
Generation of cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate by CD38 for Ca2+ signaling in interleukin-8-treated lymphokine-activated killer cells.
Rah SY, Mushtaq M, Nam TS, Kim SH, Kim UH
J Biol Chem. 2010
PubMed ID: 20442403
S1P1 and VEGFR-2 form a signaling complex with extracellularly regulated kinase 1/2 and protein kinase C-alpha regulating ML-1 thyroid carcinoma cell migration.
Bergelin N, Löf C, Balthasar S, Kalhori V, Törnquist K
Endocrinology. 2010
PubMed ID: 20501673
Changes in rat myometrial plasma membrane protein kinase A are confined to parturition.
Ku CY, Murtazina DA, Kim YS, Garfield RE, Sanborn BM
Reprod Sci. 2010
PubMed ID: 20457802
Design of selective, ATP-competitive inhibitors of Akt.
Freeman-Cook KD, Autry C, Borzillo G, Gordon D, Barbacci-Tobin E, Bernardo V, Briere D, Clark T, Corbett M, Jakubczak J, Kakar S, Knauth E, Lippa B, Luzzio MJ, Mansour M, Martinelli G, Marx M, Nelson K, Pandit J, Rajamohan F, Robinson S, Subramanyam C, Wei L, Wythes M, Morris J
J Med Chem. 2010
PubMed ID: 20481595
Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex.
Gambaryan S, Kobsar A, Rukoyatkina N, Herterich S, Geiger J, Smolenski A, Lohmann SM, Walter U
J Biol Chem. 2010
PubMed ID: 20356841
Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.
Tsang KM, Starost MF, Nesterova M, Boikos SA, Watkins T, Almeida MQ, Harran M, Li A, Collins MT, Cheadle C, Mertz EL, Leikin S, Kirschner LS, Robey P, Stratakis CA
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20421483
The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA.
Ye Y, Keyes KT, Zhang C, Perez-Polo JR, Lin Y, Birnbaum Y
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 20207816
PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-kappaB-independent manner.
Sousa LP, Lopes F, Silva DM, Tavares LP, Vieira AT, Rezende BM, Carmo AF, Russo RC, Garcia CC, Bonjardim CA, Alessandri AL, Rossi AG, Pinho V, Teixeira MM
J Leukoc Biol. 2010
PubMed ID: 20103769
High glucose stimulates adipogenic and inhibits osteogenic differentiation in MG-63 cells through cAMP/protein kinase A/extracellular signal-regulated kinase pathway.
Wang W, Zhang X, Zheng J, Yang J
Mol Cell Biochem. 2010
PubMed ID: 19949837
Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization.
Köck K, Koenen A, Giese B, Fraunholz M, May K, Siegmund W, Hammer E, Völker U, Jedlitschky G, Kroemer HK, Grube M
J Biol Chem. 2010
PubMed ID: 20159975
Role of cAMP/PKA signaling cascade in vasopressin-induced trafficking of TRPC3 channels in principal cells of the collecting duct.
Goel M, Zuo CD, Schilling WP
Am J Physiol Renal Physiol. 2010
PubMed ID: 20107112
Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications.
Jiang XS, Wassif CA, Backlund PS, Song L, Holtzclaw LA, Li Z, Yergey AL, Porter FD
Hum Mol Genet. 2010
PubMed ID: 20067919
Azole-based inhibitors of AKT/PKB for the treatment of cancer.
Zeng Q, Allen JG, Bourbeau MP, Wang X, Yao G, Tadesse S, Rider JT, Yuan CC, Hong FT, Lee MR, Zhang S, Lofgren JA, Freeman DJ, Yang S, Li C, Tominey E, Huang X, Hoffman D, Yamane HK, Fotsch C, Dominguez C, Hungate R, Zhang X
Bioorg Med Chem Lett. 2010
PubMed ID: 20137943
KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.
Lin L, Sun W, Wikenheiser AM, Kung F, Hoffman DA
Mol Cell Neurosci. 2010
PubMed ID: 20045463
Global consequences of activation loop phosphorylation on protein kinase A.
Steichen JM, Iyer GH, Li S, Saldanha SA, Deal MS, Woods VL, Taylor SS
J Biol Chem. 2010
PubMed ID: 19965870
Protein kinase A regulation of P2X(4) receptors: requirement for a specific motif in the C-terminus.
Brown DA, Yule DI
Biochim Biophys Acta. 2010
PubMed ID: 20026202
Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium.
Zeng H, Jia J, Liu A
PLoS One. 2010
PubMed ID: 21209912
Protein kinase A binds and activates heat shock factor 1.
Murshid A, Chou SD, Prince T, Zhang Y, Bharti A, Calderwood SK
PLoS One. 2010
PubMed ID: 21085490
Reciprocally coupled residues crucial for protein kinase Pak2 activity calculated by statistical coupling analysis.
Hsu YH, Traugh JA
PLoS One. 2010
PubMed ID: 20209159
Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A.
MacPherson MR, Molina P, Souchelnytskyi S, Wernstedt C, Martin-Pérez J, Portillo F, Cano A
Mol Biol Cell. 2010
PubMed ID: 19923321
cAMP-dependent axon guidance is distinctly regulated by Epac and protein kinase A.
Murray AJ, Tucker SJ, Shewan DA
J Neurosci. 2009
PubMed ID: 20007468
Protein kinase A activation confers resistance to trastuzumab in human breast cancer cell lines.
Gu L, Lau SK, Loera S, Somlo G, Kane SE
Clin Cancer Res. 2009
PubMed ID: 19920112
CD9 regulates transcription factor GCM1 and ERVWE1 expression through the cAMP/protein kinase A signaling pathway.
Muroi Y, Sakurai T, Hanashi A, Kubota K, Nagaoka K, Imakawa K
Reproduction. 2009
PubMed ID: 19692500
Regulation of protein kinase A activity by p90 ribosomal S6 kinase 1.
Gao X, Patel TB
J Biol Chem. 2009
PubMed ID: 19808666
Docosahexaenoic acid enhances hepatic serum amyloid A expression via protein kinase A-dependent mechanism.
Tai CC, Chen CY, Lee HS, Wang YC, Li TK, Mersamm HJ, Ding ST, Wang PH
J Biol Chem. 2009
PubMed ID: 19755416
Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes.
Liu R, Ramani B, Soto D, De Arcangelis V, Xiang Y
J Biol Chem. 2009
PubMed ID: 19706594
Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures.
Brown SH, Wu J, Kim C, Alberto K, Taylor SS
J Mol Biol. 2009
PubMed ID: 19748511
Modulation of Rho guanine exchange factor Lfc activity by protein kinase A-mediated phosphorylation.
Meiri D, Greeve MA, Brunet A, Finan D, Wells CD, LaRose J, Rottapel R
Mol Cell Biol. 2009
PubMed ID: 19667072
Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and Neuropilin-1.
Yamamizu K, Kawasaki K, Katayama S, Watabe T, Yamashita JK
Blood. 2009
PubMed ID: 19706882
Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head and neck cancer.
Arun P, Brown MS, Ehsanian R, Chen Z, Van Waes C
Clin Cancer Res. 2009
PubMed ID: 19789307
Activation of TR4 orphan nuclear receptor gene promoter by cAMP/PKA and C/EBP signaling.
Liu NC, Lin WJ, Yu IC, Lin HY, Liu S, Lee YF, Chang C
Endocrine. 2009
PubMed ID: 19618297
Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls.
Shelton RC, Hal Manier D, Lewis DA
Int J Neuropsychopharmacol. 2009
PubMed ID: 19573263
Inhibition of angiogenesis by extracellular protein kinase A.
Szkudlarek M, Bosio RM, Wu Q, Chin KV
Cancer Lett. 2009
PubMed ID: 19368997
Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3zeta.
Sluchanko NN, Seit-Nebi AS, Gusev NB
FEBS Lett. 2009
PubMed ID: 19647741
T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling.
Terauchi M, Li JY, Bedi B, Baek KH, Tawfeek H, Galley S, Gilbert L, Nanes MS, Zayzafoon M, Guldberg R, Lamar DL, Singer MA, Lane TF, Kronenberg HM, Weitzmann MN, Pacifici R
Cell Metab. 2009
PubMed ID: 19723499
Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway beta2-adrenergic receptor physiologic signaling.
Wang WC, Mihlbachler KA, Brunnett AC, Liggett SB
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19706446
Phosphorylation and consequent stimulation of the tyrosine kinase c-Abl by PKA in mouse spermatozoa; its implications during capacitation.
Baker MA, Hetherington L, Curry B, Aitken RJ
Dev Biol. 2009
PubMed ID: 19560455
Dynamically driven ligand selectivity in cyclic nucleotide binding domains.
Das R, Chowdhury S, Mazhab-Jafari MT, Sildas S, Selvaratnam R, Melacini G
J Biol Chem. 2009
PubMed ID: 19403523
4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.
Al Rahim M, Nakajima A, Saigusa D, Tetsu N, Maruyama Y, Shibuya M, Yamakoshi H, Tomioka Y, Iwabuchi Y, Ohizumi Y, Yamakuni T
Biochemistry. 2009
PubMed ID: 19601643
Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways.
Chung S, Furihata M, Tamura K, Uemura M, Daigo Y, Nasu Y, Miki T, Shuin T, Fujioka T, Nakamura Y, Nakagawa H
Oncogene. 2009
PubMed ID: 19483721
Prolonged seizure activity leads to increased Protein Kinase A activation in the rat pilocarpine model of status epilepticus.
Bracey JM, Kurz JE, Low B, Churn SB
Brain Res. 2009
PubMed ID: 19501060
Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
{alpha}MSH and Cyclic AMP elevating agents control melanosome pH through a protein kinase A-independent mechanism.
Cheli Y, Luciani F, Khaled M, Beuret L, Bille K, Gounon P, Ortonne JP, Bertolotto C, Ballotti R
J Biol Chem. 2009
PubMed ID: 19389708
Protein kinase A-regulated assembly of a MEF2{middle dot}HDAC4 repressor complex controls c-Jun expression in vascular smooth muscle cells.
Gordon JW, Pagiatakis C, Salma J, Du M, Andreucci JJ, Zhao J, Hou G, Perry RL, Dan Q, Courtman D, Bendeck MP, McDermott JC
J Biol Chem. 2009
PubMed ID: 19389706
PKA-mediated stabilization of FoxH1 negatively regulates ERalpha activity.
Yum J, Jeong HM, Kim S, Seo JW, Han Y, Lee KY, Yeo CY
Mol Cells. 2009
PubMed ID: 19711044
Improvement of two-way active avoidance memory requires protein kinase a activation and brain-derived neurotrophic factor expression in the dorsal hippocampus.
Datta S, Siwek DF, Huang MP
J Mol Neurosci. 2009
PubMed ID: 19418263
The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits.
Louiset E, Stratakis CA, Perraudin V, Griffin KJ, Libé R, Cabrol S, Fève B, Young J, Groussin L, Bertherat J, Lefebvre H
J Clin Endocrinol Metab. 2009
PubMed ID: 19383776
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
Tyrosine hydroxylase phosphorylation after naloxone-induced morphine withdrawal in the left ventricle.
Almela P, Victoria Milanés M, Luisa Laorden M
Basic Res Cardiol. 2009
PubMed ID: 19104749
[The role of CPI-17 in vascular calcium sensitivity regulated by protein kinase Calpha and Cepsilon in rats with hemorrhagic shock]
Xu J, Yang GM, Li T, Ming J, Chen W, Liu LM
Zhonghua Shao Shang Za Zhi. 2009
PubMed ID: 19842549
Protein phosphatase inhibitor-1 augments a protein kinase A-dependent increase in the Ca2+ loading of the sarcoplasmic reticulum without changing its Ca2+ release.
Kawashima H, Satoh H, Saotome M, Urushida T, Katoh H, Hayashi H
Circ J. 2009
PubMed ID: 19377265
cAMP enhances estrogen-related receptor alpha (ERRalpha) transcriptional activity at the SP-A promoter by increasing its interaction with protein kinase A and steroid receptor coactivator 2 (SRC-2).
Liu D, Benlhabib H, Mendelson CR
Mol Endocrinol. 2009
PubMed ID: 19264843
Gene and microRNA expression in p53-deficient day 8.5 mouse embryos.
Hosako H, Martin GS, Barrier M, Chen YA, Ivanov IV, Mirkes PE
Birth Defects Res A Clin Mol Teratol. 2009
PubMed ID: 19229884
Sustained cannabinoid agonist treatment augments CGRP release in a PKA-dependent manner.
Tumati S, Yamamura HI, St John PA, Vanderah TW, Roeske WR, Varga EV
Neuroreport. 2009
PubMed ID: 19387418
Subcellular dynamics of type II PKA in neurons.
Zhong H, Sia GM, Sato TR, Gray NW, Mao T, Khuchua Z, Huganir RL, Svoboda K
Neuron. 2009
PubMed ID: 19447092
SOX9 directly binds CREB as a novel synergism with the PKA pathway in BMP-2-induced osteochondrogenic differentiation.
Zhao L, Li G, Zhou GQ
J Bone Miner Res. 2009
PubMed ID: 19113914
Gravin dynamics regulates the subcellular distribution of PKA.
Yan X, Walkiewicz M, Carlson J, Leiphon L, Grove B
Exp Cell Res. 2009
PubMed ID: 19210988
Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination.
Vuong BQ, Lee M, Kabir S, Irimia C, Macchiarulo S, McKnight GS, Chaudhuri J
Nat Immunol. 2009
PubMed ID: 19234474
Contribution of non-catalytic core residues to activity and regulation in protein kinase A.
Yang J, Kennedy EJ, Wu J, Deal MS, Pennypacker J, Ghosh G, Taylor SS
J Biol Chem. 2009
PubMed ID: 19122195
Protein kinase A regulates resumption of meiosis by phosphorylation of Cdc25B in mammalian oocytes.
Pirino G, Wescott MP, Donovan PJ
Cell Cycle. 2009
PubMed ID: 19223768
Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development.
Pan Y, Wang C, Wang B
Dev Biol. 2009
PubMed ID: 19056373
Understanding the molecular basis of sperm capacitation through kinase design.
Visconti PE
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19144927
Calcium-dependent increases in protein kinase-A activity in mouse retinal ganglion cells are mediated by multiple adenylate cyclases.
Dunn TA, Storm DR, Feller MB
PLoS One. 2009
PubMed ID: 19924297
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Hippocampal levels of phosphorylated protein kinase A (phosphor-S96) are linked to spatial memory enhancement by SGS742.
Sunyer B, Shim KS, An G, Höger H, Lubec G
Hippocampus. 2009
PubMed ID: 18727045
Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on sperm capacitation.
Morgan DJ, Weisenhaus M, Shum S, Su T, Zheng R, Zhang C, Shokat KM, Hille B, Babcock DF, McKnight GS
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19074277
Unchanged beta-adrenergic stimulation of cardiac L-type calcium channels in Ca v 1.2 phosphorylation site S1928A mutant mice.
Lemke T, Welling A, Christel CJ, Blaich A, Bernhard D, Lenhardt P, Hofmann F, Moosmang S
J Biol Chem. 2008
PubMed ID: 18829456
Protein kinase A modulates Cdc25B activity during meiotic resumption of mouse oocytes.
Zhang Y, Zhang Z, Xu XY, Li XS, Yu M, Yu AM, Zong ZH, Yu BZ
Dev Dyn. 2008
PubMed ID: 19035343
E-cadherin expression in postnatal Schwann cells is regulated by the cAMP-dependent protein kinase a pathway.
Crawford AT, Desai D, Gokina P, Basak S, Kim HA
Glia. 2008
PubMed ID: 18551621
Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif.
Shirakawa K, Takaori-Kondo A, Yokoyama M, Izumi T, Matsui M, Io K, Sato T, Sato H, Uchiyama T
Nat Struct Mol Biol. 2008
PubMed ID: 18836454
PGE(2) induces COX-2 expression in podocytes via the EP(4) receptor through a PKA-independent mechanism.
Faour WH, Gomi K, Kennedy CR
Cell Signal. 2008
PubMed ID: 18762248
CDC25B acts as a potential target of PRKACA in fertilized mouse eggs.
Cui C, Zhao H, Zhang Z, Zong Z, Feng C, Zhang Y, Deng X, Xu X, Yu B
Biol Reprod. 2008
PubMed ID: 18633139
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation.
Nijholt IM, Dolga AM, Ostroveanu A, Luiten PG, Schmidt M, Eisel UL
Cell Signal. 2008
PubMed ID: 18565730
Prostaglandin E2 inhibits specific lung fibroblast functions via selective actions of PKA and Epac-1.
Huang SK, Wettlaufer SH, Chung J, Peters-Golden M
Am J Respir Cell Mol Biol. 2008
PubMed ID: 18421013
A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1.
Jeske NA, Diogenes A, Ruparel NB, Fehrenbacher JC, Henry M, Akopian AN, Hargreaves KM
Pain. 2008
PubMed ID: 18381233
EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.
Huston E, Lynch MJ, Mohamed A, Collins DM, Hill EV, MacLeod R, Krause E, Baillie GS, Houslay MD
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18728186
Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A.
Liu XA, Zhu LQ, Zhang Q, Shi HR, Wang SH, Wang Q, Wang JZ
Neurochem Res. 2008
PubMed ID: 18338250
Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells.
Manni S, Mauban JH, Ward CW, Bond M
J Biol Chem. 2008
PubMed ID: 18550536
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
Negative regulation of parathyroid hormone (PTH)-activated phospholipase C by PTH/PTH-related peptide receptor phosphorylation and protein kinase A.
Tawfeek HA, Abou-Samra AB
Endocrinology. 2008
PubMed ID: 18450967
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment.
Goldfinger LE, Tzima E, Stockton R, Kiosses WB, Kinbara K, Tkachenko E, Gutierrez E, Groisman A, Nguyen P, Chien S, Ginsberg MH
Circ Res. 2008
PubMed ID: 18583710
Translational regulation of lipoprotein lipase in adipocytes: depletion of cellular protein kinase Calpha activates binding of the C subunit of protein kinase A to the 3'-untranslated region of the lipoprotein lipase mRNA.
Unal R, Pokrovskaya I, Tripathi P, Monia BP, Kern PA, Ranganathan G
Biochem J. 2008
PubMed ID: 18387001
Luteinizing hormone receptor activation in ovarian granulosa cells promotes protein kinase A-dependent dephosphorylation of microtubule-associated protein 2D.
Flynn MP, Maizels ET, Karlsson AB, McAvoy T, Ahn JH, Nairn AC, Hunzicker-Dunn M
Mol Endocrinol. 2008
PubMed ID: 18467524
Regulation of transforming growth factor beta-induced responses by protein kinase A in pancreatic acinar cells.
Yang H, Lee CJ, Zhang L, Sans MD, Simeone DM
Am J Physiol Gastrointest Liver Physiol. 2008
PubMed ID: 18467503
Antidepressant-like activity of 8-Br-cAMP, a PKA activator, in the forced swim test.
Brański P, Palucha A, Szewczyk B, Wierońska JM, Pilc A, Nowak G
J Neural Transm. 2008
PubMed ID: 18239846
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG
J Cell Physiol. 2008
PubMed ID: 18064650
cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo.
Siddappa R, Martens A, Doorn J, Leusink A, Olivo C, Licht R, van Rijn L, Gaspar C, Fodde R, Janssen F, van Blitterswijk C, de Boer J
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18490653
Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons.
Schnizler K, Shutov LP, Van Kanegan MJ, Merrill MA, Nichols B, McKnight GS, Strack S, Hell JW, Usachev YM
J Neurosci. 2008
PubMed ID: 18463244
Growth factor regulation of estrogen receptor coregulator PELP1 functions via Protein Kinase A pathway.
Nagpal JK, Nair S, Chakravarty D, Rajhans R, Pothana S, Brann DW, Tekmal RR, Vadlamudi RK
Mol Cancer Res. 2008
PubMed ID: 18505929
Androgens transduce the G alphas-mediated activation of protein kinase A in prostate cells.
Bagchi G, Wu J, French J, Kim J, Moniri NH, Daaka Y
Cancer Res. 2008
PubMed ID: 18451148
Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.
Meoli E, Bossis I, Cazabat L, Mavrakis M, Horvath A, Stergiopoulos S, Shiferaw ML, Fumey G, Perlemoine K, Muchow M, Robinson-White A, Weinberg F, Nesterova M, Patronas Y, Groussin L, Bertherat J, Stratakis CA
Cancer Res. 2008
PubMed ID: 18451138
Developmentally acquired PKA localisation in mouse oocytes and embryos.
Webb RJ, Tinworth L, Thomas GM, Zaccolo M, Carroll J
Dev Biol. 2008
PubMed ID: 18367160
Protein kinase A represses skeletal myogenesis by targeting myocyte enhancer factor 2D.
Du M, Perry RL, Nowacki NB, Gordon JW, Salma J, Zhao J, Aziz A, Chan J, Siu KW, McDermott JC
Mol Cell Biol. 2008
PubMed ID: 18299387
Biochemical and structural characterization of apolipoprotein A-I binding protein, a novel phosphoprotein with a potential role in sperm capacitation.
Jha KN, Shumilin IA, Digilio LC, Chertihin O, Zheng H, Schmitz G, Visconti PE, Flickinger CJ, Minor W, Herr JC
Endocrinology. 2008
PubMed ID: 18202122
Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.
Wooldridge AA, Fortner CN, Lontay B, Akimoto T, Neppl RL, Facemire C, Datto MB, Kwon A, McCook E, Li P, Wang S, Thresher RJ, Miller SE, Perriard JC, Gavin TP, Hickner RC, Coffman TM, Somlyo AV, Yan Z, Haystead TA
J Biol Chem. 2008
PubMed ID: 18310078
Fetal ethanol exposure activates protein kinase A and impairs Shh expression in prechordal mesendoderm cells in the pathogenesis of holoprosencephaly.
Aoto K, Shikata Y, Higashiyama D, Shiota K, Motoyama J
Birth Defects Res A Clin Mol Teratol. 2008
PubMed ID: 18338389
Hypoxia suppresses the production of MMP-9 by human monocyte-derived dendritic cells and requires activation of adenosine receptor A2b via cAMP/PKA signaling pathway.
Zhao P, Li XG, Yang M, Shao Q, Wang D, Liu S, Song H, Song B, Zhang Y, Qu X
Mol Immunol. 2008
PubMed ID: 18215420
Protein kinase A and mitogen-activated protein kinase pathways mediate cAMP induction of alpha-epithelial Na+ channels (alpha-ENaC).
Mustafa SB, Castro R, Falck AJ, Petershack JA, Henson BM, Mendoza YM, Choudary A, Seidner SR
J Cell Physiol. 2008
PubMed ID: 17960568
Cyclic AMP-dependent protein kinase controls energy interconversion during the catalytic cycle of the yeast copper-ATPase.
Valverde RH, Morin I, Lowe J, Mintz E, Cuillel M, Vieyra A
FEBS Lett. 2008
PubMed ID: 18291109
Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.
Yin Z, Jones GN, Towns WH, Zhang X, Abel ED, Binkley PF, Jarjoura D, Kirschner LS
Circulation. 2008
PubMed ID: 18316483
Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca(2+)-PKCalpha-ERK pathway.
Park MH, Lee DH
Exp Mol Med. 2008
PubMed ID: 18305402
Distribution of RNA binding protein MOEP19 in the oocyte cortex and early embryo indicates pre-patterning related to blastomere polarity and trophectoderm specification.
Herr JC, Chertihin O, Digilio L, Jha KN, Vemuganti S, Flickinger CJ
Dev Biol. 2008
PubMed ID: 18191828
Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells.
Zhang L, Zambon AC, Vranizan K, Pothula K, Conklin BR, Insel PA
J Biol Chem. 2008
PubMed ID: 18048352
Melanocyte-lineage expression of Cre recombinase using Mitf regulatory elements.
Alizadeh A, Fitch KR, Niswender CM, McKnight GS, Barsh GS
Pigment Cell Melanoma Res. 2008
PubMed ID: 18353144
Combinatorial roles of protein kinase A, Ets2, and 3',5'-cyclic-adenosine monophosphate response element-binding protein-binding protein/p300 in the transcriptional control of interferon-tau expression in a trophoblast cell line.
Das P, Ezashi T, Gupta R, Roberts RM
Mol Endocrinol. 2008
PubMed ID: 17975022
Allosteric cooperativity in protein kinase A.
Masterson LR, Mascioni A, Traaseth NJ, Taylor SS, Veglia G
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18178622
Ser649 and Ser650 are the major determinants of protein kinase A-mediated activation of human hormone-sensitive lipase against lipid substrates.
Krintel C, Osmark P, Larsen MR, Resjö S, Logan DT, Holm C
PLoS ONE. 2008
PubMed ID: 19018281
HPV16 E7-dependent transformation activates NHE1 through a PKA-RhoA-induced inhibition of p38alpha.
Cardone RA, Busco G, Greco MR, Bellizzi A, Accardi R, Cafarelli A, Monterisi S, Carratù P, Casavola V, Paradiso A, Tommasino M, Reshkin SJ
PLoS ONE. 2008
PubMed ID: 18953413
Cyclic AMP enhances Smad-mediated BMP signaling through PKA-CREB pathway.
Ohta Y, Nakagawa K, Imai Y, Katagiri T, Koike T, Takaoka K
J Bone Miner Metab. 2008
PubMed ID: 18758906
PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior.
Fu Y, Han J, Ishola T, Scerbo M, Adwanikar H, Ramsey C, Neugebauer V
Mol Pain. 2008
PubMed ID: 18631385
Epidermal growth factor receptor levels are reduced in mice with targeted disruption of the protein kinase A catalytic subunit.
Oksvold MP, Funderud A, Kvissel AK, Skarpen E, Henanger H, Huitfeldt HS, Skålhegg BS, Ørstavik S
BMC Cell Biol. 2008
PubMed ID: 18380891
Tumorigenic adenovirus type 12 E1A inhibits phosphorylation of NF-kappaB by PKAc, causing loss of DNA binding and transactivation.
Guan H, Jiao J, Ricciardi RP
J Virol. 2008
PubMed ID: 17959673
PKA-dependent activation of the vascular smooth muscle isoform of KATP channels by vasoactive intestinal polypeptide and its effect on relaxation of the mesenteric resistance artery.
Yang Y, Shi Y, Guo S, Zhang S, Cui N, Shi W, Zhu D, Jiang C
Biochim Biophys Acta. 2008
PubMed ID: 17942071
Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells.
Xu H, Washington S, Verderame MF, Manni A
Breast Cancer Res Treat. 2008
PubMed ID: 17333334
Differential regulation of the apical plasma membrane Ca(2+) -ATPase by protein kinase A in parotid acinar cells.
Baggaley E, McLarnon S, Demeter I, Varga G, Bruce JI
J Biol Chem. 2007
PubMed ID: 17938178
Protein kinase A, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells.
Ji Z, Mei FC, Johnson BH, Thompson EB, Cheng X
J Biol Chem. 2007
PubMed ID: 17895245
Regulation of protein kinase D activity in adult myocardium: novel counter-regulatory roles for protein kinase Cepsilon and protein kinase A.
Haworth RS, Roberts NA, Cuello F, Avkiran M
J Mol Cell Cardiol. 2007
PubMed ID: 17964599
Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes.
Faul C, Dhume A, Schecter AD, Mundel P
Mol Cell Biol. 2007
PubMed ID: 17923693
Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain.
Liang Z, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX
J Neurochem. 2007
PubMed ID: 17908236
Prostaglandin E2 activates HPK1 kinase activity via a PKA-dependent pathway.
Sawasdikosol S, Pyarajan S, Alzabin S, Matejovic G, Burakoff SJ
J Biol Chem. 2007
PubMed ID: 17895239
Age-dependent requirement of AKAP150-anchored PKA and GluR2-lacking AMPA receptors in LTP.
Lu Y, Allen M, Halt AR, Weisenhaus M, Dallapiazza RF, Hall DD, Usachev YM, McKnight GS, Hell JW
EMBO J. 2007
PubMed ID: 17972919
FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis.
Li YF, He W, Jha KN, Klotz K, Kim YH, Mandal A, Pulido S, Digilio L, Flickinger CJ, Herr JC
J Biol Chem. 2007
PubMed ID: 17855365
AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.
Lygren B, Carlson CR, Santamaria K, Lissandron V, McSorley T, Litzenberg J, Lorenz D, Wiesner B, Rosenthal W, Zaccolo M, Taskén K, Klussmann E
EMBO Rep. 2007
PubMed ID: 17901878
The VEGFR2 and PKA pathways converge at MEK/ERK1/2 to promote survival in serum deprived neuronal cells.
Gomes E, Papa L, Hao T, Rockwell P
Mol Cell Biochem. 2007
PubMed ID: 17646929
Regulation of BAD protein by PKA, PKCdelta and phosphatases in adult rat cardiac myocytes subjected to oxidative stress.
Cieslak D, Lazou A
Mol Cells. 2007
PubMed ID: 17978575
PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity.
Wu J, Brown SH, von Daake S, Taylor SS
Science. 2007
PubMed ID: 17932298
Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release.
Xiao B, Tian X, Xie W, Jones PP, Cai S, Wang X, Jiang D, Kong H, Zhang L, Chen K, Walsh MP, Cheng H, Chen SR
J Biol Chem. 2007
PubMed ID: 17693412
Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells.
Ichikawa T, Horie-Inoue K, Ikeda K, Blumberg B, Inoue S
J Mol Endocrinol. 2007
PubMed ID: 17909264
Rosmarinic acid induces melanogenesis through protein kinase A activation signaling.
Lee J, Kim YS, Park D
Biochem Pharmacol. 2007
PubMed ID: 17651699
Activation of PKA and phosphorylation of sodium-dependent vitamin C transporter 2 by prostaglandin E2 promote osteoblast-like differentiation in MC3T3-E1 cells.
Wu X, Zeng LH, Taniguchi T, Xie QM
Cell Death Differ. 2007
PubMed ID: 17585336
Parathyroid hormone stimulates the endothelial nitric oxide synthase through protein kinase A and C pathways.
Rashid G, Bernheim J, Green J, Benchetrit S
Nephrol Dial Transplant. 2007
PubMed ID: 17545677
Regulation of matrix Gla protein by parathyroid hormone in MC3T3-E1 osteoblast-like cells involves protein kinase A and extracellular signal-regulated kinase pathways.
Suttamanatwong S, Franceschi RT, Carlson AE, Gopalakrishnan R
J Cell Biochem. 2007
PubMed ID: 17407158
Distinct responses of human granulosa lutein cells after hCG or LH stimulation in a spheroidal cell culture system.
Becker J, Walz A, Daube S, Keck C, Pietrowski D
Mol Reprod Dev. 2007
PubMed ID: 17290424
PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation.
Kim C, Cheng CY, Saldanha SA, Taylor SS
Cell. 2007
PubMed ID: 17889648
Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells.
Martin BR, Deerinck TJ, Ellisman MH, Taylor SS, Tsien RY
Chem Biol. 2007
PubMed ID: 17884635
The formation of the cAMP/protein kinase A-dependent annexin 2-S100A10 complex with cystic fibrosis conductance regulator protein (CFTR) regulates CFTR channel function.
Borthwick LA, McGaw J, Conner G, Taylor CJ, Gerke V, Mehta A, Robson L, Muimo R
Mol Biol Cell. 2007
PubMed ID: 17581860
Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy.
Ulucan C, Wang X, Baljinnyam E, Bai Y, Okumura S, Sato M, Minamisawa S, Hirotani S, Ishikawa Y
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17557924
Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6.
Zhang F, Hu Y, Huang P, Toleman CA, Paterson AJ, Kudlow JE
J Biol Chem. 2007
PubMed ID: 17565987
Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing.
Kvissel AK, Ørstavik S, Eikvar S, Brede G, Jahnsen T, Collas P, Akusjärvi G, Skålhegg BS
Exp Cell Res. 2007
PubMed ID: 17594903
Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology.
Chang CR, Blackstone C
J Biol Chem. 2007
PubMed ID: 17553808
Protein kinase A-independent cAMP stimulation of progesterone in a luteal cell model is tyrosine kinase dependent but phosphatidylinositol-3-kinase and mitogen-activated protein kinase independent.
Needle E, Piparo K, Cole D, Worrall C, Whitehead I, Mahon G, Goldsmith LT
Biol Reprod. 2007
PubMed ID: 17392500
Protein kinase A increases the binding affinity and the Ca2+ release activity of the inositol 1,4,5-trisphosphate receptor type 3 in RINm5F cells.
Chaloux B, Caron AZ, Guillemette G
Biol Cell. 2007
PubMed ID: 17373911
TNF-alpha-induced NF-kappaB/RelA Ser(276) phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway.
Jamaluddin M, Wang S, Boldogh I, Tian B, Brasier AR
Cell Signal. 2007
PubMed ID: 17317104
Transglutaminase 2 kinase activity facilitates protein kinase A-induced phosphorylation of retinoblastoma protein.
Mishra S, Melino G, Murphy LJ
J Biol Chem. 2007
PubMed ID: 17478427
Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver.
Yamamoto T, Shimano H, Inoue N, Nakagawa Y, Matsuzaka T, Takahashi A, Yahagi N, Sone H, Suzuki H, Toyoshima H, Yamada N
J Biol Chem. 2007
PubMed ID: 17296605
Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.
Tu LC, Yan X, Hood L, Lin B
Mol Cell Proteomics. 2007
PubMed ID: 17220478
Lipopolysaccharide reduces electrical coupling in microvascular endothelial cells by targeting connexin40 in a tyrosine-, ERK1/2-, PKA-, and PKC-dependent manner.
Bolon ML, Kidder GM, Simon AM, Tyml K
J Cell Physiol. 2007
PubMed ID: 17149706
Effects of cigarette smoke and alcohol on ciliated tracheal epithelium and inflammatory cell recruitment.
Elliott MK, Sisson JH, Wyatt TA
Am J Respir Cell Mol Biol. 2007
PubMed ID: 17079783
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.
Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA
Nat Med. 2007
PubMed ID: 17322895
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H
Mol Cell Proteomics. 2007
PubMed ID: 17192257
PKC alpha-mediated CREB activation is oxygen and age-dependent in rat myocardial tissue.
Di Giulio C, Rapino M, Zingariello M, Antonucci A, Cataldi A
Histochem Cell Biol. 2007
PubMed ID: 17120015
Protein kinase A dependent phosphorylation activates Mg2+ efflux in the basolateral region of the liver.
Cefaratti C, Ruse C
Mol Cell Biochem. 2007
PubMed ID: 17001449
The PKA/CREB pathway is closely involved in VEGF expression in mouse macrophages.
Jeon SH, Chae BC, Kim HA, Seo GY, Seo DW, Chun GT, Yie SW, Eom SH, Kim PH
Mol Cells. 2007
PubMed ID: 17464208
Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit.
Ahn JH, McAvoy T, Rakhilin SV, Nishi A, Greengard P, Nairn AC
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17301223
Critical role of cAMP-dependent protein kinase anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons.
Hall DD, Davare MA, Shi M, Allen ML, Weisenhaus M, McKnight GS, Hell JW
Biochemistry. 2007
PubMed ID: 17279627
Activation dependent expression of MMPs in peripheral blood mononuclear cells involves protein kinase A.
Saja K, Chatterjee U, Chatterjee BP, Sudhakaran PR
Mol Cell Biochem. 2007
PubMed ID: 17043752
Phosphorylation of a threonine unique to the short C-terminal isoform of betaII-spectrin links regulation of alpha-beta spectrin interaction to neuritogenesis.
Bignone PA, King MD, Pinder JC, Baines AJ
J Biol Chem. 2007
PubMed ID: 17088250
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.
Dai J, Jin WH, Sheng QH, Shieh CH, Wu JR, Zeng R
J Proteome Res. 2007
PubMed ID: 17203969
In vitro embryonic developmental phosphorylation of the cellular nucleic acid binding protein by cAMP-dependent protein kinase, and its relevance for biochemical activities.
Lombardo VA, Armas P, Weiner AM, Calcaterra NB
FEBS J. 2007
PubMed ID: 17166179
Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways.
Li J, O'Connor KL, Cheng X, Mei FC, Uchida T, Townsend CM, Evers BM
Mol Endocrinol. 2007
PubMed ID: 17068197
Transcriptional control of receptor activator of nuclear factor-kappaB ligand by the protein kinase A activator forskolin and the transmembrane glycoprotein 130-activating cytokine, oncostatin M, is exerted through multiple distal enhancers.
Kim S, Yamazaki M, Shevde NK, Pike JW
Mol Endocrinol. 2007
PubMed ID: 17053039
Transgenic inhibition of neuronal protein kinase A activity facilitates fear extinction.
Isiegas C, Park A, Kandel ER, Abel T, Lattal KM
J Neurosci. 2006
PubMed ID: 17151273
Caveolin-1 knockout alters beta-adrenoceptors function in mouse small intestine.
El-Yazbi AF, Cho WJ, Schulz R, Daniel EE
Am J Physiol Gastrointest Liver Physiol. 2006
PubMed ID: 16782699
Activation of STAT3 by G alpha(s) distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinase.
Liu AM, Lo RK, Wong CS, Morris C, Wise H, Wong YH
J Biol Chem. 2006
PubMed ID: 17008315
Identification of genes targeted by the androgen and PKA signaling pathways in prostate cancer cells.
Wang G, Jones SJ, Marra MA, Sadar MD
Oncogene. 2006
PubMed ID: 16751804
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Protein kinase A-mediated phosphorylation of connexin36 in mouse retina results in decreased gap junctional communication between AII amacrine cells.
Urschel S, Höher T, Schubert T, Alev C, Söhl G, Wörsdörfer P, Asahara T, Dermietzel R, Weiler R, Willecke K
J Biol Chem. 2006
PubMed ID: 16956882
Expression of uncoupling protein 3 and GLUT4 gene in skeletal muscle of preterm newborns: possible control by AMP-activated protein kinase.
Brauner P, Kopecky P, Flachs P, Kuda O, Vorlicek J, Planickova L, Vitkova I, Andreelli F, Foretz M, Viollet B, Kopecky J
Pediatr Res. 2006
PubMed ID: 16966355
Odorant receptor-derived cAMP signals direct axonal targeting.
Imai T, Suzuki M, Sakano H
Science. 2006
PubMed ID: 16990513
Phosphorylation of myosin phosphatase targeting subunit 3 (MYPT3) and regulation of protein phosphatase 1 by protein kinase A.
Yong J, Tan I, Lim L, Leung T
J Biol Chem. 2006
PubMed ID: 16920702
Hedgehog-regulated localization of Vax2 controls eye development.
Kim JW, Lemke G
Genes Dev. 2006
PubMed ID: 17043310
Kinetics of ion channel modulation by cAMP in rat hippocampal neurones.
Lancaster B, Hu H, Gibb B, Storm JF
J Physiol. 2006
PubMed ID: 16901946
Protein kinase A-mediated acceleration of the stretch activation response in murine skinned myocardium is eliminated by ablation of cMyBP-C.
Stelzer JE, Patel JR, Moss RL
Circ Res. 2006
PubMed ID: 16973906
Regulation of the rat brain Na+ -driven Cl-/HCO3 - exchanger involves protein kinase A and a multiprotein signaling complex.
Lee YS, Ouyang YB, Giffard RG
FEBS Lett. 2006
PubMed ID: 16916513
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.
Amadesi S, Cottrell GS, Divino L, Chapman K, Grady EF, Bautista F, Karanjia R, Barajas-Lopez C, Vanner S, Vergnolle N, Bunnett NW
J Physiol. 2006
PubMed ID: 16793902
PKCalpha mediates CCL18-stimulated collagen production in pulmonary fibroblasts.
Luzina IG, Highsmith K, Pochetuhen K, Nacu N, Rao JN, Atamas SP
Am J Respir Cell Mol Biol. 2006
PubMed ID: 16601239
Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast.
Peeters T, Louwet W, Geladé R, Nauwelaers D, Thevelein JM, Versele M
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16924114
Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies.
Lin X, Murray JM, Rico AC, Wang MX, Chu DT, Zhou Y, Del Rosario M, Kaufman S, Ma S, Fang E, Crawford K, Jefferson AB
Bioorg Med Chem Lett. 2006
PubMed ID: 16765046
Identification of SRC as a key PKA-stimulated tyrosine kinase involved in the capacitation-associated hyperactivation of murine spermatozoa.
Baker MA, Hetherington L, Aitken RJ
J Cell Sci. 2006
PubMed ID: 16835269
Transcriptional regulation of cyclin D2 by the PKA pathway and inducible cAMP early repressor in granulosa cells.
Muñiz LC, Yehia G, Mémin E, Ratnakar PV, Molina CA
Biol Reprod. 2006
PubMed ID: 16625003
Lipoteichoic acid-induced nitric oxide synthase expression in RAW 264.7 macrophages is mediated by cyclooxygenase-2, prostaglandin E2, protein kinase A, p38 MAPK, and nuclear factor-kappaB pathways.
Chang YC, Li PC, Chen BC, Chang MS, Wang JL, Chiu WT, Lin CH
Cell Signal. 2006
PubMed ID: 16289764
Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4.
Nirula A, Ho M, Phee H, Roose J, Weiss A
J Exp Med. 2006
PubMed ID: 16785309
An active protein kinase A (PKA) is involved in meiotic arrest of rat growing oocytes.
Kovo M, Kandli-Cohen M, Ben-Haim M, Galiani D, Carr DW, Dekel N
Reproduction. 2006
PubMed ID: 16816331
ATP binding to a unique site in the type-1 S2- inositol 1,4,5-trisphosphate receptor defines susceptibility to phosphorylation by protein kinase A.
Wagner LE, Betzenhauser MJ, Yule DI
J Biol Chem. 2006
PubMed ID: 16621795
PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes.
Hermann-Kleiter N, Thuille N, Pfeifhofer C, Gruber T, Schäfer M, Zitt C, Hatzelmann A, Schudt C, Leitges M, Baier G
Blood. 2006
PubMed ID: 16514061
Integrin receptor activation triggers converging regulation of Cav1.2 calcium channels by c-Src and protein kinase A pathways.
Gui P, Wu X, Ling S, Stotz SC, Winkfein RJ, Wilson E, Davis GE, Braun AP, Zamponi GW, Davis MJ
J Biol Chem. 2006
PubMed ID: 16554304
Involvement of protein kinase A in patterning of the mouse somatosensory cortex.
Watson RF, Abdel-Majid RM, Barnett MW, Willis BS, Katsnelson A, Gillingwater TH, McKnight GS, Kind PC, Neumann PE
J Neurosci. 2006
PubMed ID: 16707791
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics.
Willoughby D, Wong W, Schaack J, Scott JD, Cooper DM
EMBO J. 2006
PubMed ID: 16642035
Parathyroid hormone increases beta-catenin levels through Smad3 in mouse osteoblastic cells.
Tobimatsu T, Kaji H, Sowa H, Naito J, Canaff L, Hendy GN, Sugimoto T, Chihara K
Endocrinology. 2006
PubMed ID: 16484320
Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase.
Taurin S, Sandbo N, Qin Y, Browning D, Dulin NO
J Biol Chem. 2006
PubMed ID: 16476742
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Protein kinase A regulates calcium permeability of NMDA receptors.
Skeberdis VA, Chevaleyre V, Lau CG, Goldberg JH, Pettit DL, Suadicani SO, Lin Y, Bennett MV, Yuste R, Castillo PE, Zukin RS
Nat Neurosci. 2006
PubMed ID: 16531999
The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.
Petretti C, Savoian M, Montembault E, Glover DM, Prigent C, Giet R
EMBO Rep. 2006
PubMed ID: 16462731
Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation.
Hall DD, Feekes JA, Arachchige Don AS, Shi M, Hamid J, Chen L, Strack S, Zamponi GW, Horne MC, Hell JW
Biochemistry. 2006
PubMed ID: 16519540
Cyclic AMP and cyclic GMP suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation via a protein kinase A-dependent pathway.
Wang Y, Kim PK, Peng X, Loughran P, Vodovotz Y, Zhang B, Billiar TR
Apoptosis. 2006
PubMed ID: 16538385
Stress stimulates AMP-activated protein kinase and meiotic resumption in mouse oocytes.
LaRosa C, Downs SM
Biol Reprod. 2006
PubMed ID: 16280415
Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice.
Huang F, Shan J, Reiken S, Wehrens XH, Marks AR
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16481613
Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury.
Prabu SK, Anandatheerthavarada HK, Raza H, Srinivasan S, Spear JF, Avadhani NG
J Biol Chem. 2006
PubMed ID: 16303765
Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity.
Mayeenuddin LH, Garrison JC
J Biol Chem. 2006
PubMed ID: 16301320
Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors.
Vanhoose AM, Clements JM, Winder DG
J Neurosci. 2006
PubMed ID: 16436600
Dynamic binding of PKA regulatory subunit RI alpha.
Gullingsrud J, Kim C, Taylor SS, McCammon JA
Structure. 2006
PubMed ID: 16407073
Cardiac troponin C-L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C.
Schmidtmann A, Lindow C, Villard S, Heuser A, Mügge A, Gessner R, Granier C, Jaquet K
FEBS J. 2005
PubMed ID: 16302972
Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A.
Han GS, Sreenivas A, Choi MG, Chang YF, Martin SS, Baldwin EP, Carman GM
J Biol Chem. 2005
PubMed ID: 16179339
Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
Misra UK, Pizzo SV
J Biol Chem. 2005
PubMed ID: 16172130
Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A.
Niswender CM, Willis BS, Wallen A, Sweet IR, Jetton TL, Thompson BR, Wu C, Lange AJ, McKnight GS
Genesis. 2005
PubMed ID: 16155866
S100A1 enhances the L-type Ca2+ current in embryonic mouse and neonatal rat ventricular cardiomyocytes.
Reppel M, Sasse P, Piekorz R, Tang M, Roell W, Duan Y, Kletke A, Hescheler J, Nürnberg B, Fleischmann BK
J Biol Chem. 2005
PubMed ID: 16129693
Stimulation of amphiregulin expression in osteoblastic cells by parathyroid hormone requires the protein kinase A and cAMP response element-binding protein signaling pathway.
Qin L, Partridge NC
J Cell Biochem. 2005
PubMed ID: 16088955
Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.
Chang CW, Chuang HC, Yu C, Yao TP, Chen H
Mol Cell Biol. 2005
PubMed ID: 16166624
Enhanced functional gap junction neoformation by protein kinase A-dependent and Epac-dependent signals downstream of cAMP in cardiac myocytes.
Somekawa S, Fukuhara S, Nakaoka Y, Fujita H, Saito Y, Mochizuki N
Circ Res. 2005
PubMed ID: 16123333
Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons.
Ryu H, Lee J, Impey S, Ratan RR, Ferrante RJ
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16169904
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Differential expression of protein kinase A, AKAP79, and PP2B in pregnant human myometrial membranes prior to and during labor.
Ku CY, Word RA, Sanborn BM
J Soc Gynecol Investig. 2005
PubMed ID: 15914039
Protein kinase A-dependent phosphorylation of Lutheran/basal cell adhesion molecule glycoprotein regulates cell adhesion to laminin alpha5.
Gauthier E, Rahuel C, Wautier MP, El Nemer W, Gane P, Wautier JL, Cartron JP, Colin Y, Le Van Kim C
J Biol Chem. 2005
PubMed ID: 15975931
PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone.
Wang G, Qi C, Fan GH, Zhou HY, Chen SD
FEBS Lett. 2005
PubMed ID: 16004991
Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells.
D'Souza T, Agarwal R, Morin PJ
J Biol Chem. 2005
PubMed ID: 15905176
Regulation of the G(2)/M transition in Xenopus oocytes by the cAMP-dependent protein kinase.
Eyers PA, Liu J, Hayashi NR, Lewellyn AL, Gautier J, Maller JL
J Biol Chem. 2005
PubMed ID: 15860459
Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.
Cardone RA, Bagorda A, Bellizzi A, Busco G, Guerra L, Paradiso A, Casavola V, Zaccolo M, Reshkin SJ
Mol Biol Cell. 2005
PubMed ID: 15843433
Protein kinase A-dependent enhanced NMDA receptor function in pain-related synaptic plasticity in rat amygdala neurones.
Bird GC, Lash LL, Han JS, Zou X, Willis WD, Neugebauer V
J Physiol. 2005
PubMed ID: 15760935
Cell signaling through the protein kinases cAMP-dependent protein kinase, protein kinase Cepsilon, and RAF-1 regulates amphotropic murine leukemia virus envelope protein-induced syncytium formation.
Wang W, Jobbagy Z, Bird TH, Eiden MV, Anderson WB
J Biol Chem. 2005
PubMed ID: 15741175
Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK.
Hildesheim J, Salvador JM, Hollander MC, Fornace AJ
J Biol Chem. 2005
PubMed ID: 15649893
LL5beta: a regulator of postsynaptic differentiation identified in a screen for synaptically enriched transcripts at the neuromuscular junction.
Kishi M, Kummer TT, Eglen SJ, Sanes JR
J Cell Biol. 2005
PubMed ID: 15851520
Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c.
Martin MC, Allan LA, Lickrish M, Sampson C, Morrice N, Clarke PR
J Biol Chem. 2005
PubMed ID: 15703181
Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets.
Schultess J, Danielewski O, Smolenski AP
Blood. 2005
PubMed ID: 15632203
Chloride conductance is required for the protein kinase A and Rac1-dependent phosphorylation of moesin at Thr-558 by KCl in PC12 cells.
Jeon S, Kim S, Kim E, Lee JE, Kim SJ, Juhnn YS, Kim YS, Bae CD, Park J
J Biol Chem. 2005
PubMed ID: 15634677
Leptin regulation of bone resorption by the sympathetic nervous system and CART.
Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G
Nature. 2005
PubMed ID: 15724149
DNA binding of repressor nuclear factor-kappaB p50/p50 depends on phosphorylation of Ser337 by the protein kinase A catalytic subunit.
Guan H, Hou S, Ricciardi RP
J Biol Chem. 2005
PubMed ID: 15642694
Convergent regulation of skeletal muscle Ca2+ channels by dystrophin, the actin cytoskeleton, and cAMP-dependent protein kinase.
Johnson BD, Scheuer T, Catterall WA
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15753322
Consequences of lysine 72 mutation on the phosphorylation and activation state of cAMP-dependent kinase.
Iyer GH, Moore MJ, Taylor SS
J Biol Chem. 2005
PubMed ID: 15618230
Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor.
Yarrow JC, Totsukawa G, Charras GT, Mitchison TJ
Chem Biol. 2005
PubMed ID: 15797222
Allosteric network of cAMP-dependent protein kinase revealed by mutation of Tyr204 in the P+1 loop.
Yang J, Garrod SM, Deal MS, Anand GS, Woods VL, Taylor S
J Mol Biol. 2005
PubMed ID: 15663937
Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA.
Kim C, Xuong NH, Taylor SS
Science. 2005
PubMed ID: 15692043
The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival.
Gupte RS, Weng Y, Liu L, Lee MY
Cell Cycle. 2005
PubMed ID: 15655353
Endogenous protein kinase inhibitor gamma terminates immediate-early gene expression induced by cAMP-dependent protein kinase (PKA) signaling: termination depends on PKA inactivation rather than PKA export from the nucleus.
Chen X, Dai JC, Orellana SA, Greenfield EM
J Biol Chem. 2005
PubMed ID: 15557275
Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification.
Humphries KM, Deal MS, Taylor SS
J Biol Chem. 2005
PubMed ID: 15533936
Phosphorylation of HIV Nef by cAMP-dependent protein kinase.
Li PL, Wang T, Buckley KA, Chenine AL, Popov S, Ruprecht RM
Virology. 2005
PubMed ID: 15629779
A-kinase-interacting protein localizes protein kinase A in the nucleus.
Sastri M, Barraclough DM, Carmichael PT, Taylor SS
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15630084
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Protein kinase A regulates cell cycle progression of mouse fertilized eggs by means of MPF.
Yu B, Wang Y, Liu Y, Liu Y, Li X, Wu D, Zong Z, Zhang J, Yu D
Dev Dyn. 2005
PubMed ID: 15580572
Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.
Leblais V, Jo SH, Chakir K, Maltsev V, Zheng M, Crow MT, Wang W, Lakatta EG, Xiao RP
Circ Res. 2004
PubMed ID: 15539636
Retina-driven dephosphorylation of the NR2A subunit correlates with faster NMDA receptor kinetics at developing retinocollicular synapses.
Townsend M, Liu Y, Constantine-Paton M
J Neurosci. 2004
PubMed ID: 15590926
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Strong calcium entry activates mitochondrial superoxide generation, upregulating kinase signaling in hippocampal neurons.
Hongpaisan J, Winters CA, Andrews SB
J Neurosci. 2004
PubMed ID: 15574738
D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells.
Yu P, Yang Z, Jones JE, Wang Z, Owens SA, Mueller SC, Felder RA, Jose PA
Kidney Int. 2004
PubMed ID: 15569306
PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells.
Obara Y, Labudda K, Dillon TJ, Stork PJ
J Cell Sci. 2004
PubMed ID: 15546918
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.
Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R
Science. 2004
PubMed ID: 15550674
cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1.
Hoang T, Fenne IS, Cook C, Børud B, Bakke M, Lien EA, Mellgren G
J Biol Chem. 2004
PubMed ID: 15347661
Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels.
Sampson LJ, Hayabuchi Y, Standen NB, Dart C
Circ Res. 2004
PubMed ID: 15499025
Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase.
Keicher C, Gambaryan S, Schulze E, Marcus K, Meyer HE, Butt E
Biochem Biophys Res Commun. 2004
PubMed ID: 15465019
Phosphoproteomic analysis of the developing mouse brain.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP
Mol Cell Proteomics. 2004
PubMed ID: 15345747
Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation.
Frederikse PH, Yun E, Kao HT, Zigler JS, Sun Q, Qazi AS
Mol Vis. 2004
PubMed ID: 15529118
Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway.
Wang W, Zhu W, Wang S, Yang D, Crow MT, Xiao RP, Cheng H
Circ Res. 2004
PubMed ID: 15375008
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Potential role of protein tyrosine phosphatase nonreceptor type 13 in the control of oocyte meiotic maturation.
Nedachi T, Conti M
Development. 2004
PubMed ID: 15371306
Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility.
Nolan MA, Babcock DF, Wennemuth G, Brown W, Burton KA, McKnight GS
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15340140
Phosphorylation of mouse glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2) by cAMP-dependent protein kinase increases the enzyme activity.
Hu Y, Riesland L, Paterson AJ, Kudlow JE
J Biol Chem. 2004
PubMed ID: 15133036
Involvement of protein kinase C-alpha and -epsilon in extracellular Ca(2+) signalling mediated by the calcium sensing receptor.
Sakwe AM, Larsson M, Rask L
Exp Cell Res. 2004
PubMed ID: 15212956
PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters.
Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM
Mol Pharmacol. 2004
PubMed ID: 15213298
IFN-gamma activates cAMP/PKA/CREB signaling pathway in murine peritoneal macrophages.
Liu L, Wang Y, Fan Y, Li CL, Chang ZL
J Interferon Cytokine Res. 2004
PubMed ID: 15212707
AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus.
Larocca MC, Shanks RA, Tian L, Nelson DL, Stewart DM, Goldenring JR
Mol Biol Cell. 2004
PubMed ID: 15047863
Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 and its physiological implications.
Wei J, Davis KM, Wu H, Wu JY
Biochemistry. 2004
PubMed ID: 15147202
Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells.
Ahmmed GU, Mehta D, Vogel S, Holinstat M, Paria BC, Tiruppathi C, Malik AB
J Biol Chem. 2004
PubMed ID: 15016832
Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation.
Cohen AW, Razani B, Schubert W, Williams TM, Wang XB, Iyengar P, Brasaemle DL, Scherer PE, Lisanti MP
Diabetes. 2004
PubMed ID: 15111495
Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells.
Zhang W, Morris GZ, Beebe SJ
Protein Expr Purif. 2004
PubMed ID: 15039079
Rosbin: a novel homeobox-like protein gene expressed exclusively in round spermatids.
Takahashi T, Tanaka H, Iguchi N, Kitamura K, Chen Y, Maekawa M, Nishimura H, Ohta H, Miyagawa Y, Matsumiya K, Okuyama A, Nishimune Y
Biol Reprod. 2004
PubMed ID: 14724137
Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization.
Alfthan K, Heiska L, Grönholm M, Renkema GH, Carpén O
J Biol Chem. 2004
PubMed ID: 14981079
Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching.
Murayama A, Kim MS, Yanagisawa J, Takeyama K, Kato S
EMBO J. 2004
PubMed ID: 15934135
The DNA sequence and biology of human chromosome 19.
Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM
Nature. 2004
PubMed ID: 15057824
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Involvement of Salmonella pathogenicity island 2 in the up-regulation of interleukin-10 expression in macrophages: role of protein kinase A signal pathway.
Uchiya K, Groisman EA, Nikai T
Infect Immun. 2004
PubMed ID: 15039316
A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin.
Browne GJ, Proud CG
Mol Cell Biol. 2004
PubMed ID: 15024086
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.
Browne GJ, Finn SG, Proud CG
J Biol Chem. 2004
PubMed ID: 14709557
Identification and characterization of phosphorylated proteins in the human pituitary.
Giorgianni F, Beranova-Giorgianni S, Desiderio DM
Proteomics. 2004
PubMed ID: 14997482
Probing cAMP-dependent protein kinase holoenzyme complexes I alpha and II beta by FT-IR and chemical protein footprinting.
Yu S, Mei FC, Lee JC, Cheng X
Biochemistry. 2004
PubMed ID: 14967031
Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism.
Yang J, Ten Eyck LF, Xuong NH, Taylor SS
J Mol Biol. 2004
PubMed ID: 14757059
Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis.
Fluhrer R, Friedlein A, Haass C, Walter J
J Biol Chem. 2004
PubMed ID: 14576165
Localized effects of cAMP mediated by distinct routes of protein kinase A.
Taskén K, Aandahl EM
Physiol Rev. 2004
PubMed ID: 14715913
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A.
Lee H, Rezai-Zadeh N, Seto E
Mol Cell Biol. 2004
PubMed ID: 14701748
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase.
Fuller W, Eaton P, Bell JR, Shattock MJ
FASEB J. 2004
PubMed ID: 14597563
Phosphorylation of rat spermatidal protein TP2 by sperm-specific protein kinase A and modulation of its transport into the haploid nucleus.
Ullas KS, Rao MR
J Biol Chem. 2003
PubMed ID: 14514679
Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants.
Stange M, Xu L, Balshaw D, Yamaguchi N, Meissner G
J Biol Chem. 2003
PubMed ID: 14532276
Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory.
Sananbenesi F, Fischer A, Schrick C, Spiess J, Radulovic J
J Neurosci. 2003
PubMed ID: 14673008
Molecular mechanisms regulating hormone-sensitive lipase and lipolysis.
Holm C
Biochem Soc Trans. 2003
PubMed ID: 14641008
HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling.
Masci AM, Galgani M, Cassano S, De Simone S, Gallo A, De Rosa V, Zappacosta S, Racioppi L
J Leukoc Biol. 2003
PubMed ID: 12972513
Ca2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes.
Lee-Kwon W, Kim JH, Choi JW, Kawano K, Cha B, Dartt DA, Zoukhri D, Donowitz M
Am J Physiol Cell Physiol. 2003
PubMed ID: 12954600
Modulation of cardiac sodium channel gating by protein kinase A can be altered by disease-linked mutation.
Tateyama M, Rivolta I, Clancy CE, Kass RS
J Biol Chem. 2003
PubMed ID: 14500710
Phosphorylation of serine 337 of NF-kappaB p50 is critical for DNA binding.
Hou S, Guan H, Ricciardi RP
J Biol Chem. 2003
PubMed ID: 12947093
PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.
Firulli BA, Howard MJ, McDaid JR, McIlreavey L, Dionne KM, Centonze VE, Cserjesi P, Virshup DM, Firulli AB
Mol Cell. 2003
PubMed ID: 14636580
Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein.
Cartier C, Hemonnot B, Gay B, Bardy M, Sanchiz C, Devaux C, Briant L
J Biol Chem. 2003
PubMed ID: 12842892
In vitro modulation of the interaction between HA95 and LAP2beta by cAMP signaling.
Martins SB, Marstad A, Collas P
Biochemistry. 2003
PubMed ID: 12950172
Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle.
Chen CH, Howng SL, Cheng TS, Chou MH, Huang CY, Hong YR
Biochem Biophys Res Commun. 2003
PubMed ID: 12927815
Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu.
Goel A, Janknecht R
Mol Cell Biol. 2003
PubMed ID: 12917345
Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1.
Wilson GM, Lu J, Sutphen K, Sun Y, Huynh Y, Brewer G
J Biol Chem. 2003
PubMed ID: 12819195
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.
Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM, Datta SR, Greenberg ME, Licklider LJ, Lowell BB, Gygi SP, Korsmeyer SJ
Nature. 2003
PubMed ID: 12931191
Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras.
Dumaz N, Marais R
J Biol Chem. 2003
PubMed ID: 12801936
Protein kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein.
Xie J, Lee JA, Kress TL, Mowry KL, Black DL
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12851456
14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase.
Pozuelo Rubio M, Peggie M, Wong BH, Morrice N, MacKintosh C
EMBO J. 2003
PubMed ID: 12853467
Chromatin-dependent regulation of the MMTV promoter by cAMP signaling is mediated through distinct pathways.
Mulholland NM, Snyder SK, Kolla SS, Smith CL
Exp Cell Res. 2003
PubMed ID: 12837291
Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes.
Møller MT, Samari HR, Fengsrud M, Strømhaug PE, øStvold AC, Seglen PO
Biochem J. 2003
PubMed ID: 12697024
Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.
Casenghi M, Meraldi P, Weinhart U, Duncan PI, Körner R, Nigg EA
Dev Cell. 2003
PubMed ID: 12852856
Cytosolic glucocorticoid receptor interaction with nuclear factor-kappa B proteins in rat liver cells.
Widén C, Gustafsson JA, Wikström AC
Biochem J. 2003
PubMed ID: 12672265
MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14.
Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, Mahadevan LC, Arthur JS
EMBO J. 2003
PubMed ID: 12773393
Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase.
Watanabe Y, Song T, Sugimoto K, Horii M, Araki N, Tokumitsu H, Tezuka T, Yamamoto T, Tokuda M
Biochem J. 2003
PubMed ID: 12630910
Serine phosphorylation negatively regulates RhoA in vivo.
Ellerbroek SM, Wennerberg K, Burridge K
J Biol Chem. 2003
PubMed ID: 12654918
Phosphorylation enhances mitochondrial targeting of GSTA4-4 through increased affinity for binding to cytoplasmic Hsp70.
Robin MA, Prabu SK, Raza H, Anandatheerthavarada HK, Avadhani NG
J Biol Chem. 2003
PubMed ID: 12646569
A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis.
Veech RL
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12721358
Phosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortex.
Yang H, Cooley D, Legakis JE, Ge Q, Andrade R, Mattingly RR
J Biol Chem. 2003
PubMed ID: 12538592
Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization.
Shinyama H, Masuzaki H, Fang H, Flier JS
Endocrinology. 2003
PubMed ID: 12639913
Glucagon and regulation of glucose metabolism.
Jiang G, Zhang BB
Am J Physiol Endocrinol Metab. 2003
PubMed ID: 12626323
Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation.
Ficarro S, Chertihin O, Westbrook VA, White F, Jayes F, Kalab P, Marto JA, Shabanowitz J, Herr JC, Hunt DF, Visconti PE
J Biol Chem. 2003
PubMed ID: 12509440
Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure.
Akamine P, Madhusudan, Wu J, Xuong NH, Ten Eyck LF, Taylor SS
J Mol Biol. 2003
PubMed ID: 12614615
Modulation of AMPA receptors by cAMP-dependent protein kinase in preBötzinger complex inspiratory neurons regulates respiratory rhythm in the rat.
Shao XM, Ge Q, Feldman JL
J Physiol. 2003
PubMed ID: 12562968
Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform.
Shepherd M, McSorley T, Olsen AE, Johnston LA, Thomson NC, Baillie GS, Houslay MD, Bolger GB
Biochem J. 2003
PubMed ID: 12441002
cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1.
Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12578970
Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1).
Janknecht R
Oncogene. 2003
PubMed ID: 12569367
Differential regulation of P-selectin expression by protein kinase A and protein kinase G in thrombin-stimulated human platelets.
Libersan D, Rousseau G, Merhi Y
Thromb Haemost. 2003
PubMed ID: 12574812
Selective phosphorylation of the IP3R-I in vivo by cGMP-dependent protein kinase in smooth muscle.
Murthy KS, Zhou H
Am J Physiol Gastrointest Liver Physiol. 2003
PubMed ID: 12529267
Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i.
Hollinger S, Ramineni S, Hepler JR
Biochemistry. 2003
PubMed ID: 12534294
Phosphorylation of spinophilin modulates its interaction with actin filaments.
Hsieh-Wilson LC, Benfenati F, Snyder GL, Allen PB, Nairn AC, Greengard P
J Biol Chem. 2003
PubMed ID: 12417592
Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation.
Manganello JM, Huang JS, Kozasa T, Voyno-Yasenetskaya TA, Le Breton GC
J Biol Chem. 2003
PubMed ID: 12399457
A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits.
Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ
Mol Cell Neurosci. 2003
PubMed ID: 12595241
A developmental switch in the signaling cascades for LTP induction.
Yasuda H, Barth AL, Stellwagen D, Malenka RC
Nat Neurosci. 2003
PubMed ID: 12469130
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1.
Moore MJ, Kanter JR, Jones KC, Taylor SS
J Biol Chem. 2002
PubMed ID: 12372837
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Differential phosphorylation of SNAP-25 in vivo by protein kinase C and protein kinase A.
Hepp R, Cabaniols JP, Roche PA
FEBS Lett. 2002
PubMed ID: 12459461
Characterization of an A-kinase anchoring protein in human ciliary axonemes.
Kultgen PL, Byrd SK, Ostrowski LE, Milgram SL
Mol Biol Cell. 2002
PubMed ID: 12475942
Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin.
Sakurada K, Kato H, Nagumo H, Hiraoka H, Furuya K, Ikuhara T, Yamakita Y, Fukunaga K, Miyamoto E, Matsumura F, Matsuo YI, Naito Y, Sasaki Y
J Biol Chem. 2002
PubMed ID: 12237306
Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A.
Wu J, Janknecht R
J Biol Chem. 2002
PubMed ID: 12213813
Genetic and pharmacological demonstration of a role for cyclic AMP-dependent protein kinase-mediated suppression of protein phosphatases in gating the expression of late LTP.
Woo NH, Abel T, Nguyen PV
Eur J Neurosci. 2002
PubMed ID: 12453050
Phosphorylation of the stress-activated protein kinase, MEKK3, at serine 166.
Adams DG, Sachs NA, Vaillancourt RR
Arch Biochem Biophys. 2002
PubMed ID: 12392720
ACTH-induced nucleocytoplasmic translocation of salt-inducible kinase. Implication in the protein kinase A-activated gene transcription in mouse adrenocortical tumor cells.
Takemori H, Katoh Y, Horike N, Doi J, Okamoto M
J Biol Chem. 2002
PubMed ID: 12200423
Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux.
See RH, Caday-Malcolm RA, Singaraja RR, Zhou S, Silverston A, Huber MT, Moran J, James ER, Janoo R, Savill JM, Rigot V, Zhang LH, Wang M, Chimini G, Wellington CL, Tafuri SR, Hayden MR
J Biol Chem. 2002
PubMed ID: 12196520
Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta.
Liu F, Iqbal K, Grundke-Iqbal I, Gong CX
FEBS Lett. 2002
PubMed ID: 12387894
Protein kinase A and two phosphatases are components of the inositol 1,4,5-trisphosphate receptor macromolecular signaling complex.
DeSouza N, Reiken S, Ondrias K, Yang YM, Matkovich S, Marks AR
J Biol Chem. 2002
PubMed ID: 12167631
Nopp140 is a mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid glycoprotein gene.
Chiu CM, Tsay YG, Chang CJ, Lee SC
J Biol Chem. 2002
PubMed ID: 12167624
A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.
Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A
J Biol Chem. 2002
PubMed ID: 12147701
Involvement of cyclic adenosine monophosphate-dependent protein kinase A and pertussis toxin-sensitive G proteins in the migratory response of human CD14+ mononuclear cells to katacalcin.
Kaneider NC, Egger P, Wiedermann FJ, Ritter M, Wöll E, Wiedermann CJ
J Bone Miner Res. 2002
PubMed ID: 12369791
cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b.
Lou L, Urbani J, Ribeiro-Neto F, Altschuler DL
J Biol Chem. 2002
PubMed ID: 12089143
Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.
Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y
Mol Biol Cell. 2002
PubMed ID: 12221128
Müllerian inhibiting substance blocks the protein kinase A-induced expression of cytochrome p450 17alpha-hydroxylase/C(17-20) lyase mRNA in a mouse Leydig cell line independent of cAMP responsive element binding protein phosphorylation.
Laurich VM, Trbovich AM, O'Neill FH, Houk CP, Sluss PM, Payne AH, Donahoe PK, Teixeira J
Endocrinology. 2002
PubMed ID: 12193547
Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells.
Graeser R, Gannon J, Poon RY, Dubois T, Aitken A, Hunt T
J Cell Sci. 2002
PubMed ID: 12154078
Regulation of histone deacetylase 2 by protein kinase CK2.
Tsai SC, Seto E
J Biol Chem. 2002
PubMed ID: 12082111
Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity.
Niswender CM, Ishihara RW, Judge LM, Zhang C, Shokat KM, McKnight GS
J Biol Chem. 2002
PubMed ID: 12034735
Interplay between calcium, diacylglycerol, and phosphorylation in the spatial and temporal regulation of PKCalpha-GFP.
Tanimura A, Nezu A, Morita T, Hashimoto N, Tojyo Y
J Biol Chem. 2002
PubMed ID: 11997388
Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo.
Amieux PS, Howe DG, Knickerbocker H, Lee DC, Su T, Laszlo GS, Idzerda RL, McKnight GS
J Biol Chem. 2002
PubMed ID: 12004056
Autophosphorylation of the mammalian multifunctional protein that initiates de novo pyrimidine biosynthesis.
Sigoillot FD, Evans DR, Guy HI
J Biol Chem. 2002
PubMed ID: 11986331
Molecular and behavioral effects of a null mutation in all PKA C beta isoforms.
Howe DG, Wiley JC, McKnight GS
Mol Cell Neurosci. 2002
PubMed ID: 12139926
Follicle-stimulating hormone induces a gap junction-dependent dynamic change in [cAMP] and protein kinase a in mammalian oocytes.
Webb RJ, Marshall F, Swann K, Carroll J
Dev Biol. 2002
PubMed ID: 12051828
betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption.
Yao L, Arolfo MP, Dohrman DP, Jiang Z, Fan P, Fuchs S, Janak PH, Gordon AS, Diamond I
Cell. 2002
PubMed ID: 12086672
Phosphorylation of the recombinant rho1 GABA receptor.
Sedelnikova A, Weiss DS
Int J Dev Neurosci. 2002
PubMed ID: 12175859
Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms.
Dumaz N, Light Y, Marais R
Mol Cell Biol. 2002
PubMed ID: 11997508
Protein kinase A deficiency causes axially localized neural tube defects in mice.
Huang Y, Roelink H, McKnight GS
J Biol Chem. 2002
PubMed ID: 11886853
Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction.
Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S
Biochem Biophys Res Commun. 2002
PubMed ID: 12054501
Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.
Dhillon AS, Pollock C, Steen H, Shaw PE, Mischak H, Kolch W
Mol Cell Biol. 2002
PubMed ID: 11971957
Formation of inactive cAMP-saturated holoenzyme of cAMP-dependent protein kinase under physiological conditions.
Kopperud R, Christensen AE, Kjarland E, Viste K, Kleivdal H, Døskeland SO
J Biol Chem. 2002
PubMed ID: 11834733
14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity.
Kagan A, Melman YF, Krumerman A, McDonald TV
EMBO J. 2002
PubMed ID: 11953308
Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95.
Choi J, Ko J, Park E, Lee JR, Yoon J, Lim S, Kim E
J Biol Chem. 2002
PubMed ID: 11805122
A structural model of the catalytic subunit-regulatory subunit dimeric complex of the cAMP-dependent protein kinase.
Tung CS, Walsh DA, Trewhella J
J Biol Chem. 2002
PubMed ID: 11799117
Differential effects of haloperidol and clozapine on [(3)H]cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain.
Dwivedi Y, Rizavi HS, Pandey GN
J Pharmacol Exp Ther. 2002
PubMed ID: 11907174
Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion.
Tolnay M, Juang YT, Tsokos GC
Biochem J. 2002
PubMed ID: 11903055
Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
Fang X, Yu S, Tanyi JL, Lu Y, Woodgett JR, Mills GB
Mol Cell Biol. 2002
PubMed ID: 11884598
Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system.
Souza SC, Muliro KV, Liscum L, Lien P, Yamamoto MT, Schaffer JE, Dallal GE, Wang X, Kraemer FB, Obin M, Greenberg AS
J Biol Chem. 2002
PubMed ID: 11751901
Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction.
Skålhegg BS, Huang Y, Su T, Idzerda RL, McKnight GS, Burton KA
Mol Endocrinol. 2002
PubMed ID: 11875122
Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome.
Sapkota GP, Boudeau J, Deak M, Kieloch A, Morrice N, Alessi DR
Biochem J. 2002
PubMed ID: 11853558
Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK).
Goto H, Tanabe K, Manser E, Lim L, Yasui Y, Inagaki M
Genes Cells. 2002
PubMed ID: 11895474
Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel.
Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, Kass RS
Science. 2002
PubMed ID: 11799244
Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling.
Bruce JI, Shuttleworth TJ, Giovannucci DR, Yule DI
J Biol Chem. 2002
PubMed ID: 11694504
Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.
Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Gong CX
Neuroscience. 2002
PubMed ID: 12435421
Regulation of phospholipase C-gamma1 by protein kinase A-dependent phosphorylation.
Bae SS, Choi JH, Oh YS, Yun SU, Ryu SH, Suh PG
Adv Enzyme Regul. 2002
PubMed ID: 12123716
Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors.
Ko L, Cardona GR, Henrion-Caude A, Chin WW
Mol Cell Biol. 2002
PubMed ID: 11739747
Phosphorylation of cysteine string protein by protein kinase A. Implications for the modulation of exocytosis.
Evans GJ, Wilkinson MC, Graham ME, Turner KM, Chamberlain LH, Burgoyne RD, Morgan A
J Biol Chem. 2001
PubMed ID: 11604405
Phosphorylation of Ser(982) in the sodium bicarbonate cotransporter kNBC1 shifts the HCO(3)(-) : Na(+) stoichiometry from 3 : 1 to 2 : 1 in murine proximal tubule cells.
Gross E, Hawkins K, Pushkin A, Sassani P, Dukkipati R, Abuladze N, Hopfer U, Kurtz I
J Physiol. 2001
PubMed ID: 11744745
Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein.
Kawaguchi T, Takenoshita M, Kabashima T, Uyeda K
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11698644
Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2.
Janknecht R
J Biol Chem. 2001
PubMed ID: 11551945
Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding.
Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH
J Biol Chem. 2001
PubMed ID: 11533025
Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation.
Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW, Dulin N, Voyno-Yasenetskaya TA
Curr Biol. 2001
PubMed ID: 11696326
Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A.
Razani B, Lisanti MP
Am J Physiol Cell Physiol. 2001
PubMed ID: 11546661
The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytes.
Syin C, Parzy D, Traincard F, Boccaccio I, Joshi MB, Lin DT, Yang XM, Assemat K, Doerig C, Langsley G
Eur J Biochem. 2001
PubMed ID: 11559352
Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10).
Burgon PG, Lee WL, Nixon AB, Peralta EG, Casey PJ
J Biol Chem. 2001
PubMed ID: 11443111
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.
Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG
EMBO J. 2001
PubMed ID: 11500364
Glycogen synthase kinase-3: properties, functions, and regulation.
Ali A, Hoeflich KP, Woodgett JR
Chem Rev. 2001
PubMed ID: 11749387
Phosphorylation by PKA of a site unique to B-Raf kinase.
König S, Guibert B, Morice C, Vernier P, Barnier JV
C R Acad Sci III. 2001
PubMed ID: 11510412
Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin.
Prymakowska-Bosak M, Misteli T, Herrera JE, Shirakawa H, Birger Y, Garfield S, Bustin M
Mol Cell Biol. 2001
PubMed ID: 11438671
Downregulation of CIITA function by protein kinase a (PKA)-mediated phosphorylation: mechanism of prostaglandin E, cyclic AMP, and PKA inhibition of class II major histocompatibility complex expression in monocytic lines.
Li G, Harton JA, Zhu X, Ting JP
Mol Cell Biol. 2001
PubMed ID: 11416140
Modulation of the G protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding.
Thulin CD, Savage JR, McLaughlin JN, Truscott SM, Old WM, Ahn NG, Resing KA, Hamm HE, Bitensky MW, Willardson BM
J Biol Chem. 2001
PubMed ID: 11331285
Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication.
Lutz W, Lingle WL, McCormick D, Greenwood TM, Salisbury JL
J Biol Chem. 2001
PubMed ID: 11279195
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, Morrice N, Deak M, Alessi DR
J Biol Chem. 2001
PubMed ID: 11297520
Mammalian histone deacetylase 1 protein is posttranslationally modified by phosphorylation.
Cai R, Kwon P, Yan-Neale Y, Sambuccetti L, Fischer D, Cohen D
Biochem Biophys Res Commun. 2001
PubMed ID: 11327722
Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.
Cong M, Perry SJ, Lin FT, Fraser ID, Hu LA, Chen W, Pitcher JA, Scott JD, Lefkowitz RJ
J Biol Chem. 2001
PubMed ID: 11278469
Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent association.
Kleppe R, Toska K, Haavik J
J Neurochem. 2001
PubMed ID: 11359875
The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase.
Woods YL, Cohen P, Becker W, Jakes R, Goedert M, Wang X, Proud CG
Biochem J. 2001
PubMed ID: 11311121
Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.
Obsil T, Ghirlando R, Klein DC, Ganguly S, Dyda F
Cell. 2001
PubMed ID: 11336675
Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex.
Chheda MG, Ashery U, Thakur P, Rettig J, Sheng ZH
Nat Cell Biol. 2001
PubMed ID: 11283605
Phosphorylation of tau is regulated by PKN.
Taniguchi T, Kawamata T, Mukai H, Hasegawa H, Isagawa T, Yasuda M, Hashimoto T, Terashima A, Nakai M, Mori H, Ono Y, Tanaka C
J Biol Chem. 2001
PubMed ID: 11104762
Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97.
Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C
J Cell Sci. 2001
PubMed ID: 11181181
Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor.
Vang T, Torgersen KM, Sundvold V, Saxena M, Levy FO, Skålhegg BS, Hansson V, Mustelin T, Taskén K
J Exp Med. 2001
PubMed ID: 11181701
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry.
Lund ET, McKenna R, Evans DB, Sharma SK, Mathews WR
J Neurochem. 2001
PubMed ID: 11181841
Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity.
Diggle TA, Subkhankulova T, Lilley KS, Shikotra N, Willis AE, Redpath NT
Biochem J. 2001
PubMed ID: 11171059
Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: implication for receptor-mediated endocytosis.
Li Y, van Kerkhof P, Marzolo MP, Strous GJ, Bu G
Mol Cell Biol. 2001
PubMed ID: 11158305
Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation.
Zumbrunn J, Kinoshita K, Hyman AA, Näthke IS
Curr Biol. 2001
PubMed ID: 11166179
Influence of myristoylation, phosphorylation, and deamidation on the structural behavior of the N-terminus of the catalytic subunit of cAMP-dependent protein kinase.
Tholey A, Pipkorn R, Bossemeyer D, Kinzel V, Reed J
Biochemistry. 2001
PubMed ID: 11141074
Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance.
Deng X, Kornblau SM, Ruvolo PP, May WS
J Natl Cancer Inst Monogr. 2001
PubMed ID: 11158204
The neuropeptide processing enzyme EC 3.4.24.15 is modulated by protein kinase A phosphorylation.
Tullai JW, Cummins PM, Pabon A, Roberts JL, Lopingco MC, Shrimpton CN, Smith AI, Martignetti JA, Ferro ES, Glucksman MJ
J Biol Chem. 2000
PubMed ID: 10969067
cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains.
Lambrechts A, Kwiatkowski AV, Lanier LM, Bear JE, Vandekerckhove J, Ampe C, Gertler FB
J Biol Chem. 2000
PubMed ID: 10945997
The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion.
Mayor T, Stierhof YD, Tanaka K, Fry AM, Nigg EA
J Cell Biol. 2000
PubMed ID: 11076968
Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein.
Zhang F, White RL, Neufeld KL
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11050185
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Parallel instabilities of long-term potentiation, place cells, and learning caused by decreased protein kinase A activity.
Rotenberg A, Abel T, Hawkins RD, Kandel ER, Muller RU
J Neurosci. 2000
PubMed ID: 11050131
KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells.
Burkhardt M, Glazova M, Gambaryan S, Vollkommer T, Butt E, Bader B, Heermeier K, Lincoln TM, Walter U, Palmetshofer A
J Biol Chem. 2000
PubMed ID: 10922374
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.
Fang X, Yu SX, Lu Y, Bast RC, Woodgett JR, Mills GB
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11035810
Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-kappa B and the glucocorticoid receptor.
Doucas V, Shi Y, Miyamoto S, West A, Verma I, Evans RM
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11027313
The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation.
Walter AO, Seghezzi W, Korver W, Sheung J, Lees E
Oncogene. 2000
PubMed ID: 11039908
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Phosphorylation-dependent localization of microtubule-associated protein MAP2c to the actin cytoskeleton.
Ozer RS, Halpain S
Mol Biol Cell. 2000
PubMed ID: 11029056
Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells.
Komeima K, Hayashi Y, Naito Y, Watanabe Y
J Biol Chem. 2000
PubMed ID: 10874031
The unique catalytic subunit of sperm cAMP-dependent protein kinase is the product of an alternative Calpha mRNA expressed specifically in spermatogenic cells.
Agustin JT, Wilkerson CG, Witman GB
Mol Biol Cell. 2000
PubMed ID: 10982398
Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I.
Smolenski A, Poller W, Walter U, Lohmann SM
J Biol Chem. 2000
PubMed ID: 10851246
BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival.
Tan Y, Demeter MR, Ruan H, Comb MJ
J Biol Chem. 2000
PubMed ID: 10837486
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
A novel isoform of human cyclic 3',5'-adenosine monophosphate-dependent protein kinase, c alpha-s, localizes to sperm midpiece.
Reinton N, Orstavik S, Haugen TB, Jahnsen T, Taskén K, Skålhegg BS
Biol Reprod. 2000
PubMed ID: 10906071
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
Lizcano JM, Morrice N, Cohen P
Biochem J. 2000
PubMed ID: 10880354
Alternative 5'-exons of the mouse cAMP-dependent protein kinase subunit RIalpha gene are conserved and expressed in both a ubiquitous and tissue-restricted fashion.
Barradeau S, Imaizumi-Scherrer T, Weiss MC, Faust DM
FEBS Lett. 2000
PubMed ID: 10913627
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.
Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME
Mol Cell. 2000
PubMed ID: 10949026
VACM-1, a cullin gene family member, regulates cellular signaling.
Burnatowska-Hledin M, Zhao P, Capps B, Poel A, Parmelee K, Mungall C, Sharangpani A, Listenberger L
Am J Physiol Cell Physiol. 2000
PubMed ID: 10898738
Expression of a nonmyristylated variant of the catalytic subunit of protein kinase A during male germ-cell development.
Desseyn JL, Burton KA, McKnight GS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10841548
Cyclic AMP regulates the HERG K(+) channel by dual pathways.
Cui J, Melman Y, Palma E, Fishman GI, McDonald TV
Curr Biol. 2000
PubMed ID: 10837251
Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer.
Huang W, Zhou X, Lefebvre V, de Crombrugghe B
Mol Cell Biol. 2000
PubMed ID: 10805756
PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.
Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR
Cell. 2000
PubMed ID: 10830164
Dissection of behavior and psychiatric disorders using the mouse as a model.
Tarantino LM, Bucan M
Hum Mol Genet. 2000
PubMed ID: 10767319
Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain.
Diviani D, Langeberg LK, Doxsey SJ, Scott JD
Curr Biol. 2000
PubMed ID: 10753751
Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta.
Reynolds CH, Betts JC, Blackstock WP, Nebreda AR, Anderton BH
J Neurochem. 2000
PubMed ID: 10737616
Molecular cloning, genomic organization, and biochemical characterization of myristoyl-CoA:protein N-myristoyltransferase from Arabidopsis thaliana.
Qi Q, Rajala RV, Anderson W, Jiang C, Rozwadowski K, Selvaraj G, Sharma R, Datla R
J Biol Chem. 2000
PubMed ID: 10734119
Human connexin40 gap junction channels are modulated by cAMP.
van Rijen HV, van Veen TA, Hermans MM, Jongsma HJ
Cardiovasc Res. 2000
PubMed ID: 10728420
Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA.
Biondi RM, Cheung PC, Casamayor A, Deak M, Currie RA, Alessi DR
EMBO J. 2000
PubMed ID: 10698939
Phosphorylation of recombinant human ATP:citrate lyase by cAMP-dependent protein kinase abolishes homotropic allosteric regulation of the enzyme by citrate and increases the enzyme activity. Allosteric activation of ATP:citrate lyase by phosphorylated sug
Potapova IA, El-Maghrabi MR, Doronin SV, Benjamin WB
Biochemistry. 2000
PubMed ID: 10653665
Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells.
Srivenugopal KS, Mullapudi SR, Shou J, Hazra TK, Ali-Osman F
Cancer Res. 2000
PubMed ID: 10667577
Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry.
Louie DF, Gloor KK, Galasinski SC, Resing KA, Ahn NG
Protein Sci. 2000
PubMed ID: 10739259
Mutation of the RIIbeta subunit of protein kinase A differentially affects lipolysis but not gene induction in white adipose tissue.
Planas JV, Cummings DE, Idzerda RL, McKnight GS
J Biol Chem. 1999
PubMed ID: 10593917
A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase.
Blanco-Aparicio C, Torres J, Pulido R
J Cell Biol. 1999
PubMed ID: 10601328
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.
Bibb JA, Snyder GL, Nishi A, Yan Z, Meijer L, Fienberg AA, Tsai LH, Kwon YT, Girault JA, Czernik AJ, Huganir RL, Hemmings HC, Nairn AC, Greengard P
Nature. 1999
PubMed ID: 10604473
Identification and characterization of the phosphorylation sites of the guanylyl cyclase-linked natriuretic peptide receptors A and B.
Potter LR, Hunter T
Methods. 1999
PubMed ID: 10581150
Phosphorylation and regulation of Raf by Akt (protein kinase B).
Zimmermann S, Moelling K
Science. 1999
PubMed ID: 10576742
Functional regulation of L-type calcium channels via protein kinase A-mediated phosphorylation of the beta(2) subunit.
Bünemann M, Gerhardstein BL, Gao T, Hosey MM
J Biol Chem. 1999
PubMed ID: 10567342
A phospho-switch controls the dynamic association of synapsins with synaptic vesicles.
Hosaka M, Hammer RE, Südhof TC
Neuron. 1999
PubMed ID: 10571231
Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase.
Saxena M, Williams S, Taskén K, Mustelin T
Nat Cell Biol. 1999
PubMed ID: 10559944
Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt.
Kitamura T, Kitamura Y, Kuroda S, Hino Y, Ando M, Kotani K, Konishi H, Matsuzaki H, Kikkawa U, Ogawa W, Kasuga M
Mol Cell Biol. 1999
PubMed ID: 10454575
Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A.
Wang J, Brown EJ
J Biol Chem. 1999
PubMed ID: 10446213
Identification of the sites phosphorylated by cyclic AMP-dependent protein kinase on the beta 2 subunit of L-type voltage-dependent calcium channels.
Gerhardstein BL, Puri TS, Chien AJ, Hosey MM
Biochemistry. 1999
PubMed ID: 10441130
Regulation of neuronal nitric-oxide synthase by calmodulin kinases.
Hayashi Y, Nishio M, Naito Y, Yokokura H, Nimura Y, Hidaka H, Watanabe Y
J Biol Chem. 1999
PubMed ID: 10400690
Characterization of phosphorylation sites on the glutamate receptor 4 subunit of the AMPA receptors.
Carvalho AL, Kameyama K, Huganir RL
J Neurosci. 1999
PubMed ID: 10366608
Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes.
Laxminarayana D, Khan IU, Mishra N, Olorenshaw I, Taskén K, Kammer GM
J Immunol. 1999
PubMed ID: 10228048
Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase.
Matsushita M, Nairn AC
J Biol Chem. 1999
PubMed ID: 10187789
Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments.
Schneider A, Biernat J, von Bergen M, Mandelkow E, Mandelkow EM
Biochemistry. 1999
PubMed ID: 10090741
Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells.
Endo S, Suzuki M, Sumi M, Nairn AC, Morita R, Yamakawa K, Greengard P, Ito M
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10051666
Phosphorylation of human estrogen receptor alpha by protein kinase A regulates dimerization.
Chen D, Pace PE, Coombes RC, Ali S
Mol Cell Biol. 1999
PubMed ID: 9891036
Effect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress Ras-dependent Raf-1 activation.
Hu CD, Kariya K, Okada T, Qi X, Song C, Kataoka T
J Biol Chem. 1999
PubMed ID: 9867809
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Transcriptional regulation by cyclic AMP is essential for development, reproduction and survival: lessons from the transgenic mice.
Groussin L, Bertherat J
Eur J Endocrinol. 1998
PubMed ID: 9916858
New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry.
Hanger DP, Betts JC, Loviny TL, Blackstock WP, Anderton BH
J Neurochem. 1998
PubMed ID: 9832145
Architectural DNA-binding properties of the spermatidal transition proteins 1 and 2.
Lévesque D, Veilleux S, Caron N, Boissonneault G
Biochem Biophys Res Commun. 1998
PubMed ID: 9837753
Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase.
Wang JZ, Wu Q, Smith A, Grundke-Iqbal I, Iqbal K
FEBS Lett. 1998
PubMed ID: 9771888
Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.
Sengupta A, Kabat J, Novak M, Wu Q, Grundke-Iqbal I, Iqbal K
Arch Biochem Biophys. 1998
PubMed ID: 9735171
Regulation of erythroid Krüppel-like factor (EKLF) transcriptional activity by phosphorylation of a protein kinase casein kinase II site within its interaction domain.
Ouyang L, Chen X, Bieker JJ
J Biol Chem. 1998
PubMed ID: 9722526
Protein kinase A-catalyzed phosphorylation of heat shock protein 60 chaperone regulates its attachment to histone 2B in the T lymphocyte plasma membrane.
Khan IU, Wallin R, Gupta RS, Kammer GM
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9724719
14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity.
Thorson JA, Yu LW, Hsu AL, Shih NY, Graves PR, Tanner JW, Allen PM, Piwnica-Worms H, Shaw AS
Mol Cell Biol. 1998
PubMed ID: 9710607
Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase.
Cheng X, Ma Y, Moore M, Hemmings BA, Taylor SS
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9707564
Effects of phosphorylation on function of the Rad GTPase.
Moyers JS, Zhu J, Kahn CR
Biochem J. 1998
PubMed ID: 9677319
Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons.
Matsuoka Y, Li X, Bennett V
J Cell Biol. 1998
PubMed ID: 9679146
Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways.
Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F
AIDS Res Hum Retroviruses. 1998
PubMed ID: 9671211
HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.
Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C
Neuroimmunomodulation. 1998
PubMed ID: 9730685
Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells.
Michel G, Mercken M, Murayama M, Noguchi K, Ishiguro K, Imahori K, Takashima A
Biochim Biophys Acta. 1998
PubMed ID: 9565682
Identification of in vitro phosphorylation sites in the growth cone protein SCG10. Effect Of phosphorylation site mutants on microtubule-destabilizing activity.
Antonsson B, Kassel DB, Di Paolo G, Lutjens R, Riederer BM, Grenningloh G
J Biol Chem. 1998
PubMed ID: 9525956
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300.
Zhong H, Voll RE, Ghosh S
Mol Cell. 1998
PubMed ID: 9660950
Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts.
Liapi C, Takahashi N, Raynaud F, Evain-Brion D, Anderson WB
J Invest Dermatol. 1998
PubMed ID: 9540970
Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation.
Zheng-Fischhöfer Q, Biernat J, Mandelkow EM, Illenberger S, Godemann R, Mandelkow E
Eur J Biochem. 1998
PubMed ID: 9546672
Transgenic approaches to define the functional role of dual site phospholamban phosphorylation.
Luo W, Chu G, Sato Y, Zhou Z, Kadambi VJ, Kranias EG
J Biol Chem. 1998
PubMed ID: 9468536
A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry.
Jedrzejewski PT, Girod A, Tholey A, König N, Thullner S, Kinzel V, Bossemeyer D
Protein Sci. 1998
PubMed ID: 9521123
Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro.
Anthonsen MW, Rönnstrand L, Wernstedt C, Degerman E, Holm C
J Biol Chem. 1998
PubMed ID: 9417067
Cyclic AMP signaling and gene regulation.
Daniel PB, Walker WH, Habener JF
Annu Rev Nutr. 1998
PubMed ID: 9706229
Properties and phosphorylation sites of baculovirus-expressed nuclear inhibitor of protein phosphatase-1 (NIPP-1).
Vulsteke V, Beullens M, Waelkens E, Stalmans W, Bollen M
J Biol Chem. 1997
PubMed ID: 9407077
Dissecting the cooperative reassociation of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Role of Trp-196 in the catalytic subunit.
Gibson RM, Taylor SS
J Biol Chem. 1997
PubMed ID: 9405392
Expression, purification, and regulation of two isoforms of the inositol 1,4,5-trisphosphate 3-kinase.
Woodring PJ, Garrison JC
J Biol Chem. 1997
PubMed ID: 9374536
Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro.
Paudel HK
J Biol Chem. 1997
PubMed ID: 9353289
The homeodomain protein Arix interacts synergistically with cyclic AMP to regulate expression of neurotransmitter biosynthetic genes.
Swanson DJ, Zellmer E, Lewis EJ
J Biol Chem. 1997
PubMed ID: 9341190
Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain.
Sakamoto Y, Yoshida M, Semba K, Hunter T
Oncogene. 1997
PubMed ID: 9366517
The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.
Chen P, Mayne M, Power C, Nath A
J Biol Chem. 1997
PubMed ID: 9278385
Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo.
Birnbaum MJ, van Zundert B, Vaughan PS, Whitmarsh AJ, van Wijnen AJ, Davis RJ, Stein GS, Stein JL
J Cell Biochem. 1997
PubMed ID: 9213219
Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase.
Collins SP, Uhler MD
J Biol Chem. 1997
PubMed ID: 9218452
A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility.
Narayana N, Cox S, Nguyen-huu X, Ten Eyck LF, Taylor SS
Structure. 1997
PubMed ID: 9261084
cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits.
Gao T, Yatani A, Dell'Acqua ML, Sako H, Green SA, Dascal N, Scott JD, Hosey MM
Neuron. 1997
PubMed ID: 9247274
Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases.
Goedert M, Hasegawa M, Jakes R, Lawler S, Cuenda A, Cohen P
FEBS Lett. 1997
PubMed ID: 9199504
The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.
Swingler S, Gallay P, Camaur D, Song J, Abo A, Trono D
J Virol. 1997
PubMed ID: 9151826
The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism.
Zhong H, SuYang H, Erdjument-Bromage H, Tempst P, Ghosh S
Cell. 1997
PubMed ID: 9150141
Bcl-2 phosphorylation required for anti-apoptosis function.
Ito T, Deng X, Carr B, May WS
J Biol Chem. 1997
PubMed ID: 9115213
Phosphorylation and activation of brain tryptophan hydroxylase: identification of serine-58 as a substrate site for protein kinase A.
Kuhn DM, Arthur R, States JC
J Neurochem. 1997
PubMed ID: 9109552
Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase.
Kosako H, Amano M, Yanagida M, Tanabe K, Nishi Y, Kaibuchi K, Inagaki M
J Biol Chem. 1997
PubMed ID: 9099667
D-myo-inositol 1,4,5-trisphosphate 3-kinase A is activated by receptor activation through a calcium:calmodulin-dependent protein kinase II phosphorylation mechanism.
Communi D, Vanweyenberg V, Erneux C
EMBO J. 1997
PubMed ID: 9155020
Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine.
Narayana N, Cox S, Shaltiel S, Taylor SS, Xuong N
Biochemistry. 1997
PubMed ID: 9109651
Purification, characterization, and in vitro phosphorylation of the neuron-specific membrane-associated protein SCG10.
Antonsson B, Lütjens R, Di Paolo G, Kassel D, Allet B, Bernard A, Catsicas S, Grenningloh G
Protein Expr Purif. 1997
PubMed ID: 9126608
Nonstructural protein 3 of hepatitis C virus blocks the distribution of the free catalytic subunit of cyclic AMP-dependent protein kinase.
Borowski P, Oehlmann K, Heiland M, Laufs R
J Virol. 1997
PubMed ID: 9060639
The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor.
Tortora G, Damiano V, Bianco C, Baldassarre G, Bianco AR, Lanfrancone L, Pelicci PG, Ciardiello F
Oncogene. 1997
PubMed ID: 9050991
Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase.
Sprenkle AB, Davies SP, Carling D, Hardie DG, Sturgill TW
FEBS Lett. 1997
PubMed ID: 9091312
Protein kinase A (PKA)- and protein kinase C-phosphorylated glia maturation factor promotes the catalytic activity of PKA.
Zaheer A, Lim R
J Biol Chem. 1997
PubMed ID: 9030586
Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na,K-ATPase alpha 1 subunit gene promoter.
Kobayashi M, Shimomura A, Hagiwara M, Kawakami K
Nucleic Acids Res. 1997
PubMed ID: 9016641
The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase.
Paudel HK
J Biol Chem. 1997
PubMed ID: 8999860
A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor.
Abramovich C, Yakobson B, Chebath J, Revel M
EMBO J. 1997
PubMed ID: 9029147
The cleavage of protein kinase A by the kinase-splitting membranal proteinase is reproduced by meprin beta.
Chestukhin A, Muradov K, Litovchick L, Shaltiel S
J Biol Chem. 1996
PubMed ID: 8939981
Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C.
Matsuoka Y, Hughes CA, Bennett V
J Biol Chem. 1996
PubMed ID: 8810272
Ethanol causes translocation of cAMP-dependent protein kinase catalytic subunit to the nucleus.
Dohrman DP, Diamond I, Gordon AS
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8816779
The gene encoding the catalytic subunit C alpha of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1.
Taskén K, Solberg R, Zhao Y, Hansson V, Jahnsen T, Siciliano MJ
Genomics. 1996
PubMed ID: 8884279
Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha.
Imaizumi-Scherrer T, Faust DM, Bénichou JC, Hellio R, Weiss MC
J Cell Biol. 1996
PubMed ID: 8794865
Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation.
Sette C, Conti M
J Biol Chem. 1996
PubMed ID: 8663227
Regulation of protein kinase A subunits by cyclic adenosine 3',5'-monophosphate in a mouse Sertoli cell line (MSC-1): induction of RII beta messenger ribonucleic acid is independent of continuous protein synthesis.
Knutsen HK, Reinton N, Taskén KA, Hansson V, Eskild W
Biol Reprod. 1996
PubMed ID: 8793051
Cyclic AMP-dependent protein kinase phosphorylates residues in the C-terminal domain of the cardiac L-type calcium channel alpha1 subunit.
Leach RN, Brickley K, Norman RI
Biochim Biophys Acta. 1996
PubMed ID: 8664319
Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit.
Roche KW, O'Brien RJ, Mammen AL, Bernhardt J, Huganir RL
Neuron. 1996
PubMed ID: 8663994
Identification of the site in the cGMP-inhibited phosphodiesterase phosphorylated in adipocytes in response to insulin and isoproterenol.
Rahn T, Rönnstrand L, Leroy MJ, Wernstedt C, Tornqvist H, Manganiello VC, Belfrage P, Degerman E
J Biol Chem. 1996
PubMed ID: 8626720
Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase.
Borowski P, Heiland M, Oehlmann K, Becker B, Kornetzky L, Feucht H, Laufs R
Eur J Biochem. 1996
PubMed ID: 8647104
A potential site of functional modulation by protein kinase A in the cardiac Ca2+ channel alpha 1C subunit.
Perets T, Blumenstein Y, Shistik E, Lotan I, Dascal N
FEBS Lett. 1996
PubMed ID: 8612821
A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning.
Huang YY, Kandel ER, Varshavsky L, Brandon EP, Qi M, Idzerda RL, McKnight GS, Bourtchouladze R
Cell. 1995
PubMed ID: 8548807
Phosphorylation of the N-terminal intracellular tail of sucrase-isomaltase by cAMP-dependent protein kinase.
Keller P, Semenza G, Shaltiel S
Eur J Biochem. 1995
PubMed ID: 8521865
Isoform cloning, actin binding, and chromosomal localization of human erythroid dematin, a member of the villin superfamily.
Azim AC, Knoll JH, Beggs AH, Chishti AH
J Biol Chem. 1995
PubMed ID: 7615546
Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.
Golsteyn RM, Mundt KE, Fry AM, Nigg EA
J Cell Biol. 1995
PubMed ID: 7790358
Patterns of cyclic AMP-dependent protein kinase gene expression during ontogeny of the murine palate.
Greene RM, Lloyd MR, Uberti M, Nugent P, Pisano MM
J Cell Physiol. 1995
PubMed ID: 7775586
Regulation of adenylyl cyclase by protein kinase A.
Iwami G, Kawabe J, Ebina T, Cannon PJ, Homcy CJ, Ishikawa Y
J Biol Chem. 1995
PubMed ID: 7759492
Hyperphosphorylation of tau in PHF.
Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Watanabe A, Titani K, Ihara Y
Neurobiol Aging. 1995
PubMed ID: 7566346
Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262.
Drewes G, Trinczek B, Illenberger S, Biernat J, Schmitt-Ulms G, Meyer HE, Mandelkow EM, Mandelkow E
J Biol Chem. 1995
PubMed ID: 7706316
Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity.
Zhu J, Reynet C, Caldwell JS, Kahn CR
J Biol Chem. 1995
PubMed ID: 7876254
Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks.
Stappenbeck TS, Lamb JA, Corcoran CM, Green KJ
J Biol Chem. 1994
PubMed ID: 7525582
Cloning of a mouse protein kinase A catalytic subunit pseudogene and chromosomal mapping of C subunit isoforms.
Cummings DE, Edelhoff S, Disteche CM, McKnight GS
Mamm Genome. 1994
PubMed ID: 7873880
Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis.
May WS, Tyler PG, Ito T, Armstrong DK, Qatsha KA, Davidson NE
J Biol Chem. 1994
PubMed ID: 7929424
Protein kinase A phosphorylates cyclin D1 at three distinct sites within the cyclin box and at the C-terminus.
Sewing A, Müller R
Oncogene. 1994
PubMed ID: 8058338
PTP-PEST: a protein tyrosine phosphatase regulated by serine phosphorylation.
Garton AJ, Tonks NK
EMBO J. 1994
PubMed ID: 7520867
Identification of phosphorylation sites on glial fibrillary acidic protein for cdc2 kinase and Ca(2+)-calmodulin-dependent protein kinase II.
Tsujimura K, Tanaka J, Ando S, Matsuoka Y, Kusubata M, Sugiura H, Yamauchi T, Inagaki M
J Biochem. 1994
PubMed ID: 7822264
Evidence for the importance of hydrophobic residues in the interactions between the cAMP-dependent protein kinase catalytic subunit and the protein kinase inhibitors.
Baude EJ, Dignam SS, Reimann EM, Uhler MD
J Biol Chem. 1994
PubMed ID: 8027074
HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro.
Hofmann B, Nishanian P, Fan J, Nguyen T, Fahey JL
AIDS. 1994
PubMed ID: 7946090
Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements.
Trautwein C, van der Geer P, Karin M, Hunter T, Chojkier M
J Clin Invest. 1994
PubMed ID: 8200992
Molecular characterization of human stathmin expressed in Escherichia coli: site-directed mutagenesis of two phosphorylatable serines (Ser-25 and Ser-63).
Curmi PA, Maucuer A, Asselin S, Lecourtois M, Chaffotte A, Schmitter JM, Sobel A
Biochem J. 1994
PubMed ID: 8002936
cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.
Butt E, Abel K, Krieger M, Palm D, Hoppe V, Hoppe J, Walter U
J Biol Chem. 1994
PubMed ID: 8182057
Identification of the phosphorylation site in vitro for cAMP-dependent protein kinase on the rat adipocyte cGMP-inhibited cAMP phosphodiesterase.
Rascón A, Degerman E, Taira M, Meacci E, Smith CJ, Manganiello V, Belfrage P, Tornqvist H
J Biol Chem. 1994
PubMed ID: 8163498
Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase.
Komalavilas P, Lincoln TM
J Biol Chem. 1994
PubMed ID: 8132598
Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor.
Baude EJ, Dignam SS, Olsen SR, Reimann EM, Uhler MD
J Biol Chem. 1994
PubMed ID: 7905001
Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase.
Chen RH, Abate C, Blenis J
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8248197
Differential expression of cyclic AMP-dependent protein kinase isozymes in normal human melanocytes and malignant melanomas.
Beebe SJ, Salomonsky P, Holroyd C, Becker D
Cell Growth Differ. 1993
PubMed ID: 8117614
Reciprocal regulation of mRNA and protein for subunits of cAMP-dependent protein kinase (RI alpha and C alpha) by cAMP in a neoplastic B cell line (Reh).
Taskén K, Andersson KB, Skålhegg BS, Taskén KA, Hansson V, Jahnsen T, Blomhoff HK
J Biol Chem. 1993
PubMed ID: 8226875
Multiple and cooperative phosphorylation events regulate the CREM activator function.
de Groot RP, den Hertog J, Vandenheede JR, Goris J, Sassone-Corsi P
EMBO J. 1993
PubMed ID: 8404858
Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2.
Beretta L, Dobránsky T, Sobel A
J Biol Chem. 1993
PubMed ID: 8376365
Identification of phosphorylation sites in the recombinant catalytic subunit of cAMP-dependent protein kinase.
Yonemoto W, Garrod SM, Bell SM, Taylor SS
J Biol Chem. 1993
PubMed ID: 8395513
Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.
Hofmann B, Nishanian P, Nguyen T, Insixiengmay P, Fahey JL
Proc Natl Acad Sci U S A. 1993
PubMed ID: 7688126
Phosphorylation of connexin-32 by protein kinase C prevents its proteolysis by mu-calpain and m-calpain.
Elvira M, Díez JA, Wang KK, Villalobo A
J Biol Chem. 1993
PubMed ID: 8390988
Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck.
Winkler DG, Park I, Kim T, Payne NS, Walsh CT, Strominger JL, Shin J
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8506364
Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor.
Zheng J, Knighton DR, ten Eyck LF, Karlsson R, Xuong N, Taylor SS, Sowadski JM
Biochemistry. 1993
PubMed ID: 8443157
Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase.
Suko J, Maurer-Fogy I, Plank B, Bertel O, Wyskovsky W, Hohenegger M, Hellmann G
Biochim Biophys Acta. 1993
PubMed ID: 8380342
The dual role of the cAMP-dependent protein kinase C alpha subunit in T-cell receptor-triggered T-lymphocytes effector functions.
Sugiyama H, Chen P, Hunter M, Taffs R, Sitkovsky M
J Biol Chem. 1992
PubMed ID: 1281154
Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis.
Rubinfeld B, Crosier WJ, Albert I, Conroy L, Clark R, McCormick F, Polakis P
Mol Cell Biol. 1992
PubMed ID: 1406653
The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing.
Rider MH, Vandamme J, Lebeau E, Vertommen D, Vidal H, Rousseau GG, Vandekerckhove J, Hue L
Biochem J. 1992
PubMed ID: 1322130
Phosphorylation of the cystic fibrosis transmembrane conductance regulator.
Picciotto MR, Cohn JA, Bertuzzi G, Greengard P, Nairn AC
J Biol Chem. 1992
PubMed ID: 1377674
Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.
Bredt DS, Ferris CD, Snyder SH
J Biol Chem. 1992
PubMed ID: 1375933
Mechanism of interferon action. cDNA structure and regulation of a novel splice-site variant of the catalytic subunit of human protein kinase A from interferon-treated human cells.
Thomis DC, Floyd-Smith G, Samuel CE
J Biol Chem. 1992
PubMed ID: 1375229
Alteration of a cyclic AMP-dependent protein kinase phosphorylation site in the c-Fos protein augments its transforming potential.
Tratner I, Ofir R, Verma IM
Mol Cell Biol. 1992
PubMed ID: 1545828
Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity.
Segil N, Roberts SB, Heintz N
Science. 1991
PubMed ID: 1684878
Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.
Knighton DR, Zheng JH, Ten Eyck LF, Ashford VA, Xuong NH, Taylor SS, Sowadski JM
Science. 1991
PubMed ID: 1862342
Rat C alpha catalytic subunit of the cAMP-dependent protein kinase: cDNA sequence and evidence that it is the only isoform expressed in myoblasts.
Wiemann S, Voss H, Kinzel V, Pyerin W
Biochim Biophys Acta. 1991
PubMed ID: 1711374
Endogenous cleavage of the Arg-379-Ala-380 bond in vitronectin results in a distinct conformational change which 'buries' Ser-378, its site of phosphorylation by protein kinase A.
Chain D, Korc-Grodzicki B, Kreizman T, Shaltiel S
Biochem J. 1991
PubMed ID: 1706595
Amino acid sequence of in vivo phosphorylation sites in the main intrinsic protein (MIP) of lens membranes.
Lampe PD, Johnson RG
Eur J Biochem. 1990
PubMed ID: 2176601
HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism.
Hofmann B, Nishanian P, Baldwin RL, Insixiengmay P, Nel A, Fahey JL
J Immunol. 1990
PubMed ID: 1978848
Protein kinase A phosphorylates retinal phosducin on serine 73 in situ.
Lee RH, Brown BM, Lolley RN
J Biol Chem. 1990
PubMed ID: 2394752
Phosphate groups as substrate determinants for casein kinase I action.
Flotow H, Graves PR, Wang AQ, Fiol CJ, Roeske RW, Roach PJ
J Biol Chem. 1990
PubMed ID: 2117608
Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver.
Clarke PR, Hardie DG
EMBO J. 1990
PubMed ID: 2369897
Ca2(+)-calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteins.
Tokui T, Yamauchi T, Yano T, Nishi Y, Kusagawa M, Yatani R, Inagaki M
Biochem Biophys Res Commun. 1990
PubMed ID: 2114109
Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-alpha-helical head domain.
Inagaki M, Gonda Y, Nishizawa K, Kitamura S, Sato C, Ando S, Tanabe K, Kikuchi K, Tsuiki S, Nishi Y
J Biol Chem. 1990
PubMed ID: 2155236
Localization of phosphoserine residues in the alpha subunit of rabbit skeletal muscle phosphorylase kinase.
Meyer HE, Meyer GF, Dirks H, Heilmeyer LM
Eur J Biochem. 1990
PubMed ID: 2108025
Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.
Beebe SJ, Oyen O, Sandberg M, Frøysa A, Hansson V, Jahnsen T
Mol Endocrinol. 1990
PubMed ID: 2342480
cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.
Taylor SS, Buechler JA, Yonemoto W
Annu Rev Biochem. 1990
PubMed ID: 2165385
Platelet glycoprotein Ib beta is phosphorylated on serine 166 by cyclic AMP-dependent protein kinase.
Wardell MR, Reynolds CC, Berndt MC, Wallace RW, Fox JE
J Biol Chem. 1989
PubMed ID: 2504723
Phosphorylation modulates the activity of glycine N-methyltransferase, a folate binding protein. In vitro phosphorylation is inhibited by the natural folate ligand.
Wagner C, Decha-Umphai W, Corbin J
J Biol Chem. 1989
PubMed ID: 2722853
Primary structure of the cAMP-dependent phosphorylation site of the plasma membrane calcium pump.
James PH, Pruschy M, Vorherr TE, Penniston JT, Carafoli E
Biochemistry. 1989
PubMed ID: 2548572
Domain- and sequence-specific phosphorylation of vimentin induces disassembly of the filament structure.
Ando S, Tanabe K, Gonda Y, Sato C, Inagaki M
Biochemistry. 1989
PubMed ID: 2500966
A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit C alpha.
Maldonado F, Hanks SK
Nucleic Acids Res. 1988
PubMed ID: 2843813
Phosphorylation of beta-glucuronidases from human normal liver and hepatoma by cAMP-dependent protein kinase.
Ono M, Taniguchi N, Makita A, Fujita M, Sekiya C, Namiki M
J Biol Chem. 1988
PubMed ID: 2833520
Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase.
Chrivia JC, Uhler MD, McKnight GS
J Biol Chem. 1988
PubMed ID: 2833513
Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase.
Uhler MD, Chrivia JC, McKnight GS
J Biol Chem. 1986
PubMed ID: 3023318
Sequence analysis of phospholamban. Identification of phosphorylation sites and two major structural domains.
Simmerman HK, Collins JH, Theibert JL, Wegener AD, Jones LR
J Biol Chem. 1986
PubMed ID: 3759968
Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase.
Campbell DG, Hardie DG, Vulliet PR
J Biol Chem. 1986
PubMed ID: 2874140
Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase.
Uhler MD, Carmichael DF, Lee DC, Chrivia JC, Krebs EG, McKnight GS
Proc Natl Acad Sci U S A. 1986
PubMed ID: 3456589
Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis.
Carrey EA, Campbell DG, Hardie DG
EMBO J. 1985
PubMed ID: 4092695
Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase.
Kishimoto A, Nishiyama K, Nakanishi H, Uratsuji Y, Nomura H, Takeyama Y, Nishizuka Y
J Biol Chem. 1985
PubMed ID: 2413024
Regulation of 6-phosphofructo-2-kinase activity by cyclic AMP-dependent phosphorylation.
el-Maghrabi MR, Claus TH, Pilkis J, Pilkis SJ
Proc Natl Acad Sci U S A. 1982
PubMed ID: 6281762
Complete amino acid sequence of the catalytic subunit of bovine cardiac muscle cyclic AMP-dependent protein kinase.
Shoji S, Parmelee DC, Wade RD, Kumar S, Ericsson LH, Walsh KA, Neurath H, Long GL, Demaille JG, Fischer EH, Titani K
Proc Natl Acad Sci U S A. 1981
PubMed ID: 6262777
Sequence of two phosphorylated sites in the catalytic subunit of bovine cardiac muscle adenosine 3':5'-monophosphate-dependent protein kinase.
Shoji S, Titani K, Demaille JG, Fischer EH
J Biol Chem. 1979
PubMed ID: 221492
Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation.
Joh TH, Park DH, Reis DJ
Proc Natl Acad Sci U S A. 1978
PubMed ID: 33381
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Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	5566	18747	25636
EnsEMBL Gene(s)	ENSG00000072062	ENSMUSG00000005469	ENSRNOG00000005257
Unigene	Hs.631630	Mm.19111	Rn.20
Homologene	PRKACA	Prkaca	Prkaca
OMIM	601639	N/A	N/A
GeneCards	PRKACA	N/A	N/A
Beta Cell Genomics	DT.100018343 DT.100788463 DT.418922 DT.92427153 DT.95158689 DT.99955392	DT.110851851 DT.535374 DT.91341731 DT.94263558	N/A
Reactome	P17612	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	5566	18747	25636

External resources from NIDDK Consortium Interconnectivity Network Top Help

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Interactor	Interactor	Sources	Classification	Pubmed IDs
PRKACA	RANBP9	IntAct, BioGRID	empirical	20936779
PRKACA	SEPT5-GP1BB	HPRD	empirical	2504723
PRKACA	DNM1L	MINT	empirical	17721437
PRKACA	ACTR1A	Reactome	predicted	12852856
PRKACA	AKAP9	Reactome	predicted	12852856
PRKACA	WASF2	MINT	empirical	16483316
PRKACA	SORBS3	MINT	empirical	16483316
PRKACA	CACNG2	HPRD	empirical	11805122
PRKACA	TUBB4A	Reactome	predicted	12852856
PRKACA	TUBB4B	Reactome	predicted	12852856
PRKACA	NDRG1	HPRD	empirical	17220478
PRKACA	DCTN2	Reactome	predicted	12852856
PRKACA	RGS14	HPRD	empirical	12534294
PRKACA	CAMKK2	BioGRID	empirical	10187789
PRKACA	KLF1	HPRD	empirical	9722526
PRKACA	GNA13	HPRD	empirical	12399457
PRKACA	CETN1	HPRD	empirical	11279195
PRKACA	CETN2	Reactome	predicted	12852856
PRKACA	CFL1	MINT	empirical	19424295
PRKACA	PLK4	Reactome	predicted	12852856
PRKACA	CFTR	HPRD	empirical	1377674
PRKACA	SDCCAG8	Reactome	predicted	12852856
PRKACA	PPP1R17	HPRD	empirical	10051666
PRKACA	CBX1	IntAct	empirical	21888893
PRKACA	CNTRL	Reactome	predicted	12852856
PRKACA	STMN2	HPRD	empirical	9525956 9126608
PRKACA	ADCY5	HPRD	empirical	7759492
PRKACA	FGFR1OP	Reactome	predicted	12852856
PRKACA	PKIG	IntAct, BioGRID	empirical	17353931
PRKACA	CEP250	Reactome	predicted	12852856
PRKACA	DCTN3	Reactome	predicted	12852856
PRKACA	CBX3	IntAct	empirical	21888893
PRKACA	ADD1	HPRD	empirical	8810272
PRKACA	ADD2	HPRD	empirical	9679146 8810272
PRKACA	CLTC	IntAct	empirical	20936779
PRKACA	NEDD1	Reactome	predicted	12852856
PRKACA	CLDN3	HPRD	empirical	15905176
PRKACA	CREB1	BioGRID	empirical	11500364
PRKACA	CREM	HPRD	empirical	8404858
PRKACA	CSK	HPRD	empirical	11181701
PRKACA	CSNK1D	Reactome	predicted	12852856
PRKACA	CSNK1E	Reactome	predicted	12852856
PRKACA	AANAT	HPRD	empirical	11336675
PRKACA	ADRB1	MINT	empirical	18188154
PRKACA	ADRBK1	HPRD	empirical	11278469
PRKACA	AKAP14	HPRD	empirical	12475942
PRKACA	DCTN1	Reactome	predicted	12852856
PRKACA	DYNC1H1	Reactome	predicted	12852856
PRKACA	DYNC1I2	Reactome	predicted	12852856
PRKACA	DSP	HPRD	empirical	7525582
PRKACA	ABCA1	HPRD	empirical	12196520
PRKACA	EGFR	HPRD, BioGRID	empirical	9050991
PRKACA	EPB49	HPRD	empirical	7615546
PRKACA	ESR1	HPRD	empirical	9891036
PRKACA	ETV1	HPRD	empirical	12569367 12917345 12213813 11551945
PRKACA	CEP164	Reactome	predicted	12852856
PRKACA	MAPRE1	Reactome	predicted	12852856
PRKACA	NINL	Reactome	predicted	12852856
PRKACA	AZI1	Reactome	predicted	12852856
PRKACA	CEP152	Reactome	predicted	12852856
PRKACA	CLASP1	Reactome	predicted	12852856
PRKACA	SIK3	IntAct, BioGRID	empirical	20936779
PRKACA	FOS	HPRD	empirical	8248197 1545828
PRKACA	SNAPIN	HPRD	empirical	11283605
PRKACA	GABRB3	BioGRID	empirical	12595241
PRKACA	GABRR1	HPRD	empirical	12175859
PRKACA	GAD1	BioGRID	empirical	15147202
PRKACA	GAD2	BioGRID	empirical	15147202
PRKACA	RASGRP3	BioGRID	empirical	15213298
PRKACA	USP49	IntAct, BioGRID	empirical	19615732
PRKACA	GFAP	HPRD	empirical	2155236 9099667 7822264 2114109
PRKACA	AKAP8L	HPRD	empirical	12950172
PRKACA	GJA5	HPRD	empirical	10728420
PRKACA	GJB1	HPRD	empirical	8390988
PRKACA	GNMT	HPRD	empirical	12697024 2722853
PRKACA	GPKOW	IntAct	empirical	21880142
PRKACA	GMFB	HPRD	empirical	9030586
PRKACA	GRIA1	HPRD, MINT	empirical	8663994
PRKACA	GRIA4	HPRD, MINT	empirical	10366608
PRKACA	GRIN1	IntAct	empirical	10862698
PRKACA	NR3C1	HPRD	empirical	11027313
PRKACA	GSK3A	HPRD	empirical	11035810 11884598 11749387 12054501
PRKACA	GSK3B	HPRD	empirical	12147701
PRKACA	GUSB	HPRD	empirical	2833520
PRKACA	EEF2K	HPRD	empirical	11500364 14709557 15024086 11171059
PRKACA	GYS1	HPRD	empirical	2117608
PRKACA	HDAC1	BioGRID	empirical	11327722 12082111
PRKACA	HMGN1	HPRD	empirical	11438671 12773393 10739259
PRKACA	HMGN2	HPRD	empirical	11438671
PRKACA	HMGCR	HPRD	empirical	2369897
PRKACA	HNRNPD	HPRD	empirical	12819195 11903055
PRKACA	APC	HPRD	empirical	11050185 11166179
PRKACA	HSP90AA1	Reactome	predicted	12852856
PRKACA	HSPD1	HPRD	empirical	9724719
PRKACA	IFNAR1	HPRD	empirical	9029147
PRKACA	IRF2	BioGRID	empirical	9213219
PRKACA	ITGA4	HPRD	empirical	11533025
PRKACA	ITPKA	HPRD	empirical	9374536 9155020
PRKACA	ITPKB	HPRD	empirical	9374536
PRKACA	ITPR1	HPRD	empirical	8132598 12529267
PRKACA	ITPR2	HPRD	empirical	11694504
PRKACA	KCNH2	HPRD	empirical	11953308 10837251
PRKACA	KCNJ2	MINT	empirical	19691494
PRKACA	KCNJ12	HPRD, MINT	empirical	11181181
PRKACA	RHOA	HPRD	empirical	12654918
PRKACA	STMN1	HPRD	empirical	8376365 8002936
PRKACA	LCK	HPRD	empirical	8506364
PRKACA	LCP1	HPRD	empirical	10446213
PRKACA	LIMK1	MINT	empirical	19424295
PRKACA	LIPE	HPRD, MINT	empirical	9417067 14641008 19664063
PRKACA	PHOX2A	HPRD	empirical	9341190
PRKACA	LRP1	HPRD	empirical	11158305
PRKACA	ASIC1	HPRD, BioGRID	empirical	12578970
PRKACA	MBP	HPRD, BioGRID	empirical	2413024 8647104
PRKACA	MC4R	HPRD	empirical	12639913
PRKACA	MEF2D	BioGRID	empirical	18299387
PRKACA	MAP3K3	HPRD	empirical	12392720
PRKACA	MEP1B	HPRD	empirical	8939981
PRKACA	MGMT	HPRD, BioGRID	empirical	10667577
PRKACA	CIITA	HPRD	empirical	11416140
PRKACA	MIP	HPRD	empirical	2176601
PRKACA	ATF1	HPRD	empirical	9016641
PRKACA	ACLY	HPRD	empirical	10653665
PRKACA	NEK2	Reactome	predicted	12852856
PRKACA	NFKB1	HPRD	empirical	12947093
PRKACA	NFKBIA	MINT	empirical	9150141
PRKACA	NFKBIB	MINT	empirical	9150141
PRKACA	NOS1	HPRD	empirical	10400690 10874031 12630910 1375933
PRKACA	ATP2B1	HPRD	empirical	2548572
PRKACA	ODF2	Reactome	predicted	12852856
PRKACA	PAFAH1B1	Reactome	predicted	12852856
PRKACA	PCM1	Reactome	predicted	12852856
PRKACA	PCNT	Reactome	predicted	12852856
PRKACA	NIN	HPRD, BioGRID	empirical	12927815
PRKACA	CDK16	HPRD	empirical	12154078
PRKACA	PDC	HPRD	empirical	2394752 11331285
PRKACA	PDE3A	MINT	empirical	17124499
PRKACA	PDE3B	HPRD	empirical	8626720 8163498 10454575
PRKACA	PDE4B	HPRD	empirical	12441002
PRKACA	PDE4D	HPRD	empirical	8663227
PRKACA	PDPK1	HPRD	empirical	10698939
PRKACA	PFKFB2	HPRD	empirical	12853467 1322130
PRKACA	PHKA1	HPRD	empirical	2108025
PRKACA	PLIN1	HPRD	empirical	11751901
PRKACA	PLK1	Reactome	predicted	12852856
PRKACA	FXYD1	HPRD	empirical	14597563
PRKACA	PLN	HPRD	empirical	3759968 9468536
PRKACA	POU2F1	BioGRID	empirical	1684878
PRKACA	RSBN1	HPRD	empirical	14724137
PRKACA	NDE1	Reactome	predicted	12852856
PRKACA	PPP1R8	HPRD, BioGRID	empirical	9407077
PRKACA	CEP192	Reactome	predicted	12852856
PRKACA	HAUS2	Reactome	predicted	12852856
PRKACA	PPP2R1A	IntAct, Reactome	empirical	16857963 12852856
PRKACA	PKIA	HPRD, BioGRID	empirical	8027074 7905001
PRKACA	CCDC88A	IntAct, BioGRID	empirical	20936779
PRKACA	CEP72	Reactome	predicted	12852856
PRKACA	PRKAR1A	HPRD, IntAct, Reactome	empirical	9405392 11834733 17353931 15655353
PRKACA	PRKAR1B	Reactome	predicted
PRKACA	CDK5RAP2	Reactome	predicted	12852856
PRKACA	PRKAR2A	Reactome, Sanger Interaction Map	predicted	15345047
PRKACA	PRKAR2B	Reactome	predicted	12852856
PRKACA	CENPJ	Reactome	predicted	12852856
PRKACA	HDAC8	HPRD, BioGRID	empirical	14701748 12082111
PRKACA	PSEN1	HPRD	empirical	14576165
PRKACA	AKIP1	HPRD, IntAct, BioGRID	empirical	15630084
PRKACA	BAD	HPRD, BioGRID	empirical	12931191 10949026 10837486 10880354 11500364
PRKACA	PTBP1	HPRD	empirical	12851456
PRKACA	PTPN7	HPRD	empirical	10559944
PRKACA	PTPN12	HPRD	empirical	7520867
PRKACA	PTPN13	HPRD	empirical	15371306
PRKACA	PTPRR	HPRD	empirical	10601328
PRKACA	RAF1	HPRD	empirical	11971957 11997508 10576742 9710607 9091312
PRKACA	RAP1A	HPRD	empirical	9867809
PRKACA	RAP1B	HPRD	empirical	12089143
PRKACA	RAP1GAP	HPRD	empirical	1406653
PRKACA	RASGRF1	HPRD	empirical	12538592
PRKACA	CCND1	HPRD	empirical	8058338
PRKACA	BCL2	HPRD	empirical	11158204 7929424 9115213
PRKACA	RELA	HPRD, MINT	empirical	9660950 9150141
PRKACA	RGS10	HPRD	empirical	11443111
PRKACA	RGS13	BioGRID	empirical	20974683
PRKACA	APOBEC3G	BioGRID	empirical	18836454
PRKACA	RRAD	HPRD	empirical	7876254 9677319
PRKACA	RYR1	HPRD	empirical	8380342 14532276
PRKACA	RYR2	HPRD, BioGRID	empirical	10830164
PRKACA	SI	HPRD	empirical	8521865
PRKACA	SLC2A2	HPRD	empirical	8626492
PRKACA	SLC2A4	IntAct	empirical	16396496
PRKACA	SNAP25	HPRD	empirical	12459461
PRKACA	SPTBN1	HPRD	empirical	17088250
PRKACA	SRC	HPRD	empirical	15546918
PRKACA	BRAF	HPRD	empirical	11510412
PRKACA	AURKA	HPRD	empirical	11039908
PRKACA	STK11	HPRD	empirical	11297520 11853558
PRKACA	SYN1	HPRD	empirical	10571231 12237306
PRKACA	SYN2	HPRD	empirical	10571231
PRKACA	TCF3	BioGRID	empirical	15934135
PRKACA	TH	HPRD	empirical	2874140 11359875
PRKACA	THOP1	HPRD	empirical	10969067
PRKACA	TNP1	BioGRID	empirical	9837753
PRKACA	TNP2	BioGRID	empirical	9837753
PRKACA	TPH1	HPRD	empirical	9109552
PRKACA	TUBA4A	Reactome	predicted	12852856
PRKACA	TUBG1	Reactome	predicted	12852856
PRKACA	UBC	BioGRID	empirical	21139048 21906983
PRKACA	VASP	HPRD	empirical	8182057 10922374 10851246
PRKACA	VIM	HPRD	empirical	2500966 11895474
PRKACA	VTN	HPRD	empirical	1706595
PRKACA	WT1	HPRD	empirical	9366517
PRKACA	YWHAG	Reactome	predicted	12852856
PRKACA	YWHAZ	MINT	empirical	16376338
PRKACA	CACNA1C	HPRD	empirical	8612821 9247274 8664319
PRKACA	CACNB2	HPRD	empirical	10441130 10567342
PRKACA	ALMS1	Reactome	predicted	12852856
PRKACA	TUBA1A	Reactome	predicted	12852856
PRKACA	CAD	HPRD	empirical	11986331 4092695
PRKACA	NUP85	HPRD	empirical	10753751
PRKACA	CEP76	Reactome	predicted	12852856
PRKACA	CEP290	Reactome	predicted	12852856
PRKACA	CEP63	Reactome	predicted	12852856
PRKACA	CEP70	Reactome	predicted	12852856
PRKACA	DNAJC5	HPRD	empirical	11604405 14997482
PRKACA	CUL5	HPRD	empirical	10898738
PRKACA	HIST2H2BE	BioGRID	empirical	8647104
PRKACA	HIST1H4A	BioGRID	empirical	8647104
PRKACA	CEP78	Reactome	predicted	12852856
PRKACA	PPP1R1B	HPRD, Reactome	empirical	10604473
PRKACA	PPP1R9B	HPRD	empirical	12417592
PRKACA	OFD1	Reactome	predicted	12852856
PRKACA	CAV1	BioGRID	empirical	11546661
PRKACA	SSNA1	Reactome	predicted	12852856
PRKACA	DYNLL1	Reactome	predicted	12852856
PRKACA	SLC4A4	HPRD	empirical	11744745
PRKACA	IQGAP1	HPRD, BioGRID	empirical	12938160
PRKACA	BTRC	IntAct, BioGRID	empirical	19615732
PRKACA	NOLC1	HPRD	empirical	12167624
PRKACA	ASIC3	BioGRID	empirical	12578970
PRKACA	TRIP10	BioGRID	empirical	15047863
PRKACA	SLC9A3R2	HPRD	empirical	12954600
PRKACA	HAND1	HPRD, BioGRID	empirical	14636580
PRKACA	HAND2	HPRD, BioGRID	empirical	14636580
PRKACA	CEP41	Reactome	predicted	12852856
PRKACA	CEP135	Reactome	predicted	12852856
PRKACA	CEP57	Reactome	predicted	12852856
PRKACA	CCP110	Reactome	predicted	12852856
PRKACA	CKAP5	Reactome	predicted	12852856
PRKACA	SFI1	Reactome	predicted	12852856
PRKACA	CDK1	Reactome	predicted	12852856