PRKAB1

Summary Top Help

Gene Description:

protein kinase, AMP-activated, beta 1 non-catalytic subunit

Synonyms:

1300015D22Rik, E430008F22, AMPK, PRKAB1, HAMPKb, AU021155, Prkab1

Orthologs:

Human PRKAB1 (protein-coding), Mouse Prkab1 (protein-coding), Rat Prkab1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr12:120105558..120119435 (13.88 kb) View in Genome Browser

(Mouse) NCBIM37 - chr5:116463595..116474517 (10.92 kb) View in Genome Browser

(Rat) RGSC3.4 - chr12:41840866..41851241 (10.38 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PRKAB1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PRKAB1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 3

Biocarta: 2

Reactome: 11

NCI-Nature Pathway Interaction Database: 3

Gene Ontology: 13

Publications from PubMed Top Help

Type 1 Diabetes Publications: 4

Publications: 176

The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2.
Gan Z, Burkart-Hartman EM, Han DH, Finck B, Leone TC, Smith EY, Ayala JE, Holloszy J, Kelly DP
Genes Dev. 2011
PubMed ID: 22135324
Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity.
Galic S, Fullerton MD, Schertzer JD, Sikkema S, Marcinko K, Walkley CR, Izon D, Honeyman J, Chen ZP, van Denderen BJ, Kemp BE, Steinberg GR
J Clin Invest. 2011
PubMed ID: 22080866
Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.
Kulkarni SS, Karlsson HK, Szekeres F, Chibalin AV, Krook A, Zierath JR
J Biol Chem. 2011
PubMed ID: 21873433
AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.
O'Neill HM, Maarbjerg SJ, Crane JD, Jeppesen J, Jørgensen SB, Schertzer JD, Shyroka O, Kiens B, van Denderen BJ, Tarnopolsky MA, Kemp BE, Richter EA, Steinberg GR
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21896769
The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.
Tong WH, Sourbier C, Kovtunovych G, Jeong SY, Vira M, Ghosh M, Romero VV, Sougrat R, Vaulont S, Viollet B, Kim YS, Lee S, Trepel J, Srinivasan R, Bratslavsky G, Yang Y, Linehan WM, Rouault TA
Cancer Cell. 2011
PubMed ID: 21907923
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.
Mihaylova MM, Shaw RJ
Nat Cell Biol. 2011
PubMed ID: 21892142
Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels.
Mungai PT, Waypa GB, Jairaman A, Prakriya M, Dokic D, Ball MK, Schumacker PT
Mol Cell Biol. 2011
PubMed ID: 21670147
AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia.
Chhipa RR, Wu Y, Ip C
Cell Signal. 2011
PubMed ID: 21554950
[Advances of LKB1-AMPK-mTOR Signaling Pathway in Tumor].
Zhang X, Sun L, Zhong D
Zhongguo Fei Ai Za Zhi. 2011
PubMed ID: 21859551
Glucose deprivation activates AMPK and induces cell death through modulation of Akt in ovarian cancer cells.
Priebe A, Tan L, Wahl H, Kueck A, He G, Kwok R, Opipari A, Liu JR
Gynecol Oncol. 2011
PubMed ID: 21570709
Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.
Löffler AS, Alers S, Dieterle AM, Keppeler H, Franz-Wachtel M, Kundu M, Campbell DG, Wesselborg S, Alessi DR, Stork B
Autophagy. 2011
PubMed ID: 21460634
AMPK is a direct adenylate charge-regulated protein kinase.
Oakhill JS, Steel R, Chen ZP, Scott JW, Ling N, Tam S, Kemp BE
Science. 2011
PubMed ID: 21680840
AMPK induces MUC5B expression via p38 MAPK in NCI-H292 airway epithelial cells.
Bae CH, Kim JW, Ye SB, Song SY, Kim YW, Park SY, Kim YD
Biochem Biophys Res Commun. 2011
PubMed ID: 21619869
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Adiponectin (15-36) stimulates steroidogenic acute regulatory (StAR) protein expression and cortisol production in human adrenocortical cells: role of AMPK and MAPK kinase pathways.
Ramanjaneya M, Conner AC, Brown JE, Chen J, Digby JE, Barber TM, Lehnert H, Randeva HS
Biochim Biophys Acta. 2011
PubMed ID: 21334384
Structural insights into the architecture and allostery of full-length AMP-activated protein kinase.
Zhu L, Chen L, Zhou XM, Zhang YY, Zhang YJ, Zhao J, Ji SR, Wu JW, Wu Y
Structure. 2011
PubMed ID: 21481774
Prognostic impact of AMP-activated protein kinase expression in ovarian carcinoma: correlation of protein expression and GC/TOF-MS-based metabolomics.
Buckendahl AC, Budczies J, Fiehn O, Darb-Esfahani S, Kind T, Noske A, Weichert W, Sehouli J, Braicu E, Dietel M, Denkert C
Oncol Rep. 2011
PubMed ID: 21271224
Enhanced technique to measure proteins in single segments of human skeletal muscle fibers: fiber-type dependence of AMPK-alpha1 and -beta1.
Murphy RM
J Appl Physiol. 2011
PubMed ID: 21088205
AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies.
Vingtdeux V, Davies P, Dickson DW, Marambaud P
Acta Neuropathol. 2011
PubMed ID: 20957377
Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways.
Rashid A, Liu C, Sanli T, Tsiani E, Singh G, Bristow RG, Dayes I, Lukka H, Wright J, Tsakiridis T
Radiat Oncol. 2011
PubMed ID: 22029423
IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway.
Duan X, Ponomareva L, Veeranki S, Choubey D
PLoS One. 2011
PubMed ID: 21573174
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
C/EBPβ is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells.
Choudhury M, Qadri I, Rahman SM, Schroeder-Gloeckler J, Janssen RC, Friedman JE
Mol Cell Endocrinol. 2011
PubMed ID: 20797423
Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells.
Lee YK, Park OJ
Oncol Rep. 2010
PubMed ID: 21042744
The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation.
Green AS, Chapuis N, Maciel TT, Willems L, Lambert M, Arnoult C, Boyer O, Bardet V, Park S, Foretz M, Viollet B, Ifrah N, Dreyfus F, Hermine O, Moura IC, Lacombe C, Mayeux P, Bouscary D, Tamburini J
Blood. 2010
PubMed ID: 20668229
A role for AMPK in increased insulin action after serum starvation.
Ching JK, Rajguru P, Marupudi N, Banerjee S, Fisher JS
Am J Physiol Cell Physiol. 2010
PubMed ID: 20810907
Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.
Jablonski KA, McAteer JB, de Bakker PI, Franks PW, Pollin TI, Hanson RL, Saxena R, Fowler S, Shuldiner AR, Knowler WC, Altshuler D, Florez JC, Diabetes Prevention Program Research Group
Diabetes. 2010
PubMed ID: 20682687
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
AMP-activated protein kinase positively regulates FGF-2-stimulated VEGF synthesis in osteoblasts.
Kato K, Tokuda H, Adachi S, Matsushima-Nishiwaki R, Natsume H, Yamakawa K, Gu Y, Otsuka T, Kozawa O
Biochem Biophys Res Commun. 2010
PubMed ID: 20708602
The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.
Moreno D, Towler MC, Hardie DG, Knecht E, Sanz P
Mol Biol Cell. 2010
PubMed ID: 20534808
Network organization of the human autophagy system.
Behrends C, Sowa ME, Gygi SP, Harper JW
Nature. 2010
PubMed ID: 20562859
Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase.
Mankouri J, Tedbury PR, Gretton S, Hughes ME, Griffin SD, Dallas ML, Green KA, Hardie DG, Peers C, Harris M
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20534540
Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1.
Yang Z, Kahn BB, Shi H, Xue BZ
J Biol Chem. 2010
PubMed ID: 20421294
Activation of AMP-activated protein kinase stimulates the nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in human diploid fibroblasts.
Kwon HJ, Rhim JH, Jang IS, Kim GE, Park SC, Yeo EJ
Exp Mol Med. 2010
PubMed ID: 20177150
Regulation of Na+-coupled glucose carrier SGLT1 by AMP-activated protein kinase.
Sopjani M, Bhavsar SK, Fraser S, Kemp BE, Föller M, Lang F
Mol Membr Biol. 2010
PubMed ID: 20334581
Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK.
Gaidhu MP, Anthony NM, Patel P, Hawke TJ, Ceddia RB
Am J Physiol Cell Physiol. 2010
PubMed ID: 20107043
AMPK and SIRT1: a long-standing partnership?
Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, Ido Y
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 20103737
The AMPK-FoxO3A axis as a target for cancer treatment.
Chiacchiera F, Simone C
Cell Cycle. 2010
PubMed ID: 20190568
AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators.
García-García C, Fumarola C, Navaratnam N, Carling D, López-Rivas A
Biochem Pharmacol. 2010
PubMed ID: 19896469
Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP.
Fogarty S, Hawley SA, Green KA, Saner N, Mustard KJ, Hardie DG
Biochem J. 2010
PubMed ID: 19958286
Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells.
Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F
J Biol Chem. 2010
PubMed ID: 20018878
Carcinoma cells activate AMP-activated protein kinase-dependent autophagy as survival response to kaempferol-mediated energetic impairment.
Filomeni G, Desideri E, Cardaci S, Graziani I, Piccirillo S, Rotilio G, Ciriolo MR
Autophagy. 2010
PubMed ID: 20083895
Chlorophyll a, an active anti-proliferative compound of Ludwigia octovalvis, activates the CD95 (APO-1/CD95) system and AMPK pathway in 3T3-L1 cells.
Wu SJ, Ng LT, Wang GH, Huang YJ, Chen JL, Sun FM
Food Chem Toxicol. 2010
PubMed ID: 19963029
The association of AMPK with ULK1 regulates autophagy.
Lee JW, Park S, Takahashi Y, Wang HG
PLoS One. 2010
PubMed ID: 21072212
Phospholipase D1 mediates AMP-activated protein kinase signaling for glucose uptake.
Kim JH, Park JM, Yea K, Kim HW, Suh PG, Ryu SH
PLoS One. 2010
PubMed ID: 20231899
The role of AMP-activated protein kinase in the cardiovascular system.
Nagata D, Hirata Y
Hypertens Res. 2010
PubMed ID: 19911004
AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance.
Dzamko N, van Denderen BJ, Hevener AL, Jørgensen SB, Honeyman J, Galic S, Chen ZP, Watt MJ, Campbell DJ, Steinberg GR, Kemp BE
J Biol Chem. 2010
PubMed ID: 19892703
Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function.
Quinn JM, Tam S, Sims NA, Saleh H, McGregor NE, Poulton IJ, Scott JW, Gillespie MT, Kemp BE, van Denderen BJ
FASEB J. 2010
PubMed ID: 19723702
Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF
Circulation. 2009
PubMed ID: 19948975
Activation of AMP-activated protein kinase suppresses oxidized low-density lipoprotein-induced macrophage proliferation.
Ishii N, Matsumura T, Kinoshita H, Motoshima H, Kojima K, Tsutsumi A, Kawasaki S, Yano M, Senokuchi T, Asano T, Nishikawa T, Araki E
J Biol Chem. 2009
PubMed ID: 19843515
CCL2 is a negative regulator of AMP-activated protein kinase to sustain mTOR complex-1 activation, survivin expression, and cell survival in human prostate cancer PC3 cells.
Roca H, Varsos ZS, Pienta KJ
Neoplasia. 2009
PubMed ID: 20019839
AMPK: Evidence for an energy-sensing cytokinetic tumor suppressor.
Vazquez-Martin A, Oliveras-Ferraros C, Lopez-Bonet E, Menendez JA
Cell Cycle. 2009
PubMed ID: 19844168
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
AMP-activated protein kinase mediates the interferon-gamma-induced decrease in intestinal epithelial barrier function.
Scharl M, Paul G, Barrett KE, McCole DF
J Biol Chem. 2009
PubMed ID: 19654324
Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin.
Li XN, Song J, Zhang L, LeMaire SA, Hou X, Zhang C, Coselli JS, Chen L, Wang XL, Zhang Y, Shen YH
Diabetes. 2009
PubMed ID: 19592618
AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells.
Harhaji-Trajkovic L, Vilimanovich U, Kravic-Stevovic T, Bumbasirevic V, Trajkovic V
J Cell Mol Med. 2009
PubMed ID: 20196784
Down-regulation of AMP-activated protein kinase sensitizes DU145 carcinoma to Fas-induced apoptosis via c-FLIP degradation.
Jung SN, Park IJ, Kim MJ, Kang I, Choe W, Kim SS, Ha J
Exp Cell Res. 2009
PubMed ID: 19477172
LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.
Jansen M, Ten Klooster JP, Offerhaus GJ, Clevers H
Physiol Rev. 2009
PubMed ID: 19584313
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells.
Zhou J, Huang W, Tao R, Ibaragi S, Lan F, Ido Y, Wu X, Alekseyev YO, Lenburg ME, Hu GF, Luo Z
Oncogene. 2009
PubMed ID: 19347029
Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ
Mol Cell Proteomics. 2009
PubMed ID: 19131326
Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma.
Drakos E, Atsaves V, Li J, Leventaki V, Andreeff M, Medeiros LJ, Rassidakis GZ
Leukemia. 2009
PubMed ID: 19225536
AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells.
Hallows KR, Alzamora R, Li H, Gong F, Smolak C, Neumann D, Pastor-Soler NM
Am J Physiol Cell Physiol. 2009
PubMed ID: 19211918
Regulation of erythrocyte survival by AMP-activated protein kinase.
Föller M, Sopjani M, Koka S, Gu S, Mahmud H, Wang K, Floride E, Schleicher E, Schulz E, Münzel T, Lang F
FASEB J. 2009
PubMed ID: 19050047
Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle.
Gibala MJ, McGee SL, Garnham AP, Howlett KF, Snow RJ, Hargreaves M
J Appl Physiol. 2009
PubMed ID: 19112161
AMP kinase signaling determines whether c-Jun N-terminal kinase promotes survival or apoptosis during glucose deprivation.
Yun H, Kim HS, Lee S, Kang I, Kim SS, Choe W, Ha J
Carcinogenesis. 2009
PubMed ID: 19037093
AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.
Dasgupta B, Milbrandt J
Dev Cell. 2009
PubMed ID: 19217427
Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.
Ruaño G, Bernene J, Windemuth A, Bower B, Wencker D, Seip RL, Kocherla M, Holford TR, Petit WA, Hanks S
Clin Chim Acta. 2009
PubMed ID: 18996102
Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells.
Suchankova G, Nelson LE, Gerhart-Hines Z, Kelly M, Gauthier MS, Saha AK, Ido Y, Puigserver P, Ruderman NB
Biochem Biophys Res Commun. 2009
PubMed ID: 19071085
Histological evaluation of AMPK signalling in primary breast cancer.
Hadad SM, Baker L, Quinlan PR, Robertson KE, Bray SE, Thomson G, Kellock D, Jordan LB, Purdie CA, Hardie DG, Fleming S, Thompson AM
BMC Cancer. 2009
PubMed ID: 19723334
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
The phagosomal proteome in interferon-gamma-activated macrophages.
Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P
Immunity. 2009
PubMed ID: 19144319
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
Myocardial hypertrophy and the maturation of fatty acid oxidation in the newborn human heart.
Yatscoff MA, Jaswal JS, Grant MR, Greenwood R, Lukat T, Beker DL, Rebeyka IM, Lopaschuk GD
Pediatr Res. 2008
PubMed ID: 18614968
UVB irradiation regulates Cox-2 mRNA stability through AMPK and HuR in human keratinocytes.
Zhang J, Bowden GT
Mol Carcinog. 2008
PubMed ID: 18449856
AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes.
Cao C, Lu S, Kivlin R, Wallin B, Card E, Bagdasarian A, Tamakloe T, Chu WM, Guan KL, Wan Y
J Biol Chem. 2008
PubMed ID: 18715874
Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.
Papandreou I, Lim AL, Laderoute K, Denko NC
Cell Death Differ. 2008
PubMed ID: 18551130
Bidirectional actions of hydrogen peroxide on endothelial nitric-oxide synthase phosphorylation and function: co-commitment and interplay of Akt and AMPK.
Hu Z, Chen J, Wei Q, Xia Y
J Biol Chem. 2008
PubMed ID: 18617528
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
Wang J, Yuan Y, Zhou Y, Guo L, Zhang L, Kuai X, Deng B, Pan Z, Li D, He F
J Proteome Res. 2008
PubMed ID: 18624398
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Lysophosphatidic acid and adenylyl cyclase inhibitor increase proliferation of senescent human diploid fibroblasts by inhibiting adenosine monophosphate-activated protein kinase.
Rhim JH, Jang IS, Song KY, Ha MK, Cho SC, Yeo EJ, Park SC
Rejuvenation Res. 2008
PubMed ID: 18729810
Modulation of the activities of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2-deoxyglucose.
Jiang W, Zhu Z, Thompson HJ
Mol Carcinog. 2008
PubMed ID: 18247380
Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression.
Thornton C, Sardini A, Carling D
J Biol Chem. 2008
PubMed ID: 18436530
AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance.
Gauthier MS, Miyoshi H, Souza SC, Cacicedo JM, Saha AK, Greenberg AS, Ruderman NB
J Biol Chem. 2008
PubMed ID: 18390901
Identification and characterization of a novel folliculin-interacting protein FNIP2.
Hasumi H, Baba M, Hong SB, Hasumi Y, Huang Y, Yao M, Valera VA, Linehan WM, Schmidt LS
Gene. 2008
PubMed ID: 18403135
Role of AMP-activated protein kinase in autophagy and proteasome function.
Viana R, Aguado C, Esteban I, Moreno D, Viollet B, Knecht E, Sanz P
Biochem Biophys Res Commun. 2008
PubMed ID: 18328803
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ
Mol Cell. 2008
PubMed ID: 18439900
AMP-activated protein kinase inhibits transforming growth factor-beta-induced Smad3-dependent transcription and myofibroblast transdifferentiation.
Mishra R, Cool BL, Laderoute KR, Foretz M, Viollet B, Simonson MS
J Biol Chem. 2008
PubMed ID: 18250161
Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells.
Jung SN, Yang WK, Kim J, Kim HS, Kim EJ, Yun H, Park H, Kim SS, Choe W, Kang I, Ha J
Carcinogenesis. 2008
PubMed ID: 18258605
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5.
McGee SL, van Denderen BJ, Howlett KF, Mollica J, Schertzer JD, Kemp BE, Hargreaves M
Diabetes. 2008
PubMed ID: 18184930
SIRT1 Acts as a Nutrient-sensitive Growth Suppressor and Its Loss Is Associated with Increased AMPK and Telomerase Activity.
Narala SR, Allsopp RC, Wells TB, Zhang G, Prasad P, Coussens MJ, Rossi DJ, Weissman IL, Vaziri H
Mol Biol Cell. 2008
PubMed ID: 18184747
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
AMP-activated protein kinase subunit interactions: beta1:gamma1 association requires beta1 Thr-263 and Tyr-267.
Iseli TJ, Oakhill JS, Bailey MF, Wee S, Walter M, van Denderen BJ, Castelli LA, Katsis F, Witters LA, Stapleton D, Macaulay SL, Michell BJ, Kemp BE
J Biol Chem. 2008
PubMed ID: 18079111
Phosphoproteome of resting human platelets.
Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schütz C, Walter U, Gambaryan S, Sickmann A
J Proteome Res. 2008
PubMed ID: 18088087
Shear stress-induced activation of the AMP-activated protein kinase regulates FoxO1a and angiopoietin-2 in endothelial cells.
Dixit M, Bess E, Fisslthaler B, Härtel FV, Noll T, Busse R, Fleming I
Cardiovasc Res. 2008
PubMed ID: 18006475
The function study on the interaction between Grb2 and AMPK.
Pan Z, Wang J, Yin X, Xie P, Yang J, Jiang J, Zhang L, He F
Mol Cell Biochem. 2008
PubMed ID: 17849173
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells.
Dowling RJ, Zakikhani M, Fantus IG, Pollak M, Sonenberg N
Cancer Res. 2007
PubMed ID: 18006825
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor.
Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP, Brunet A
J Biol Chem. 2007
PubMed ID: 17711846
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.
Hardie DG
Nat Rev Mol Cell Biol. 2007
PubMed ID: 17712357
Activation of adenosine monophosphate activated protein kinase inhibits growth of multiple myeloma cells.
Baumann P, Mandl-Weber S, Emmerich B, Straka C, Schmidmaier R
Exp Cell Res. 2007
PubMed ID: 17669398
Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2.
Um JH, Yang S, Yamazaki S, Kang H, Viollet B, Foretz M, Chung JH
J Biol Chem. 2007
PubMed ID: 17525164
Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794.
Tzatsos A, Tsichlis PN
J Biol Chem. 2007
PubMed ID: 17459875
5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling.
Su RY, Chao Y, Chen TY, Huang DY, Lin WW
Mol Cancer Ther. 2007
PubMed ID: 17513605
Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer.
Carretero J, Medina PP, Blanco R, Smit L, Tang M, Roncador G, Maestre L, Conde E, Lopez-Rios F, Clevers HC, Sanchez-Cespedes M
Oncogene. 2007
PubMed ID: 16953221
AMP-activated protein kinase in metabolic control and insulin signaling.
Towler MC, Hardie DG
Circ Res. 2007
PubMed ID: 17307971
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Inhibition of AMP-activated protein kinase suppresses IL-2 expression through down-regulation of NF-AT and AP-1 activation in Jurkat T cells.
Jhun BS, Lee JY, Oh YT, Lee JH, Choe W, Baik HH, Kim SS, Yoon KS, Ha J, Kang I
Biochem Biophys Res Commun. 2006
PubMed ID: 17097050
Leptin activates AMP-activated protein kinase in hepatic cells via a JAK2-dependent pathway.
Uotani S, Abe T, Yamaguchi Y
Biochem Biophys Res Commun. 2006
PubMed ID: 17054914
A revised model for AMP-activated protein kinase structure: The alpha-subunit binds to both the beta- and gamma-subunits although there is no direct binding between the beta- and gamma-subunits.
Wong KA, Lodish HF
J Biol Chem. 2006
PubMed ID: 17012231
AMPK regulation of the growth of cultured human keratinocytes.
Saha AK, Persons K, Safer JD, Luo Z, Holick MF, Ruderman NB
Biochem Biophys Res Commun. 2006
PubMed ID: 16949049
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.
Baba M, Hong SB, Sharma N, Warren MB, Nickerson ML, Iwamatsu A, Esposito D, Gillette WK, Hopkins RF, Hartley JL, Furihata M, Oishi S, Zhen W, Burke TR, Linehan WM, Schmidt LS, Zbar B
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17028174
Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle.
Dreyer HC, Fujita S, Cadenas JG, Chinkes DL, Volpi E, Rasmussen BB
J Physiol. 2006
PubMed ID: 16873412
Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart.
Li J, Coven DL, Miller EJ, Hu X, Young ME, Carling D, Sinusas AJ, Young LH
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16648175
TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase.
Solaz-Fuster MC, Gimeno-Alcañiz JV, Casado M, Sanz P
Cell Signal. 2006
PubMed ID: 16624523
Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase.
Berasi SP, Huard C, Li D, Shih HH, Sun Y, Zhong W, Paulsen JE, Brown EL, Gimeno RE, Martinez RV
J Biol Chem. 2006
PubMed ID: 16849326
Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta.
Stahmann N, Woods A, Carling D, Heller R
Mol Cell Biol. 2006
PubMed ID: 16880506
Higher skeletal muscle alpha2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exercise.
Roepstorff C, Thiele M, Hillig T, Pilegaard H, Richter EA, Wojtaszewski JF, Kiens B
J Physiol. 2006
PubMed ID: 16600998
AMPK activation inhibits the expression of HIF-1alpha induced by insulin and IGF-1.
Treins C, Murdaca J, Van Obberghen E, Giorgetti-Peraldi S
Biochem Biophys Res Commun. 2006
PubMed ID: 16516166
The finished DNA sequence of human chromosome 12.
Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA, Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
Nature. 2006
PubMed ID: 16541075
Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes.
Sun MW, Lee JY, de Bakker PI, Burtt NP, Almgren P, Råstam L, Tuomi T, Gaudet D, Daly MJ, Hirschhorn JN, Altshuler D, Groop L, Florez JC
Diabetes. 2006
PubMed ID: 16505254
Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells.
Kanellis J, Kandane RK, Etemadmoghadam D, Fraser SA, Mount PF, Levidiotis V, Kemp BE, Power DA
Immunol Cell Biol. 2006
PubMed ID: 16405649
Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS.
Moser K, White FM
J Proteome Res. 2006
PubMed ID: 16396499
14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.
Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR
J Cell Sci. 2005
PubMed ID: 16306228
Structural basis for glycogen recognition by AMP-activated protein kinase.
Polekhina G, Gupta A, van Denderen BJ, Feil SC, Kemp BE, Stapleton D, Parker MW
Structure. 2005
PubMed ID: 16216577
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Glycogen debranching enzyme association with beta-subunit regulates AMP-activated protein kinase activity.
Sakoda H, Fujishiro M, Fujio J, Shojima N, Ogihara T, Kushiyama A, Fukushima Y, Anai M, Ono H, Kikuchi M, Horike N, Viana AY, Uchijima Y, Kurihara H, Asano T
Am J Physiol Endocrinol Metab. 2005
PubMed ID: 15886229
Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways.
Hwang JT, Ha J, Park OJ
Biochem Biophys Res Commun. 2005
PubMed ID: 15896711
Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics.
Chen MB, McAinch AJ, Macaulay SL, Castelli LA, O'brien PE, Dixon JB, Cameron-Smith D, Kemp BE, Steinberg GR
J Clin Endocrinol Metab. 2005
PubMed ID: 15769985
AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270).
Iseli TJ, Walter M, van Denderen BJ, Katsis F, Witters LA, Kemp BE, Michell BJ, Stapleton D
J Biol Chem. 2005
PubMed ID: 15695819
AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells.
Nakamaru K, Matsumoto K, Taguchi T, Suefuji M, Murata Y, Igata M, Kawashima J, Kondo T, Motoshima H, Tsuruzoe K, Miyamura N, Toyonaga T, Araki E
Biochem Biophys Res Commun. 2005
PubMed ID: 15694368
Crystallization of the glycogen-binding domain of the AMP-activated protein kinase beta subunit and preliminary X-ray analysis.
Polekhina G, Feil SC, Gupta A, O'Donnell P, Stapleton D, Parker MW
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005
PubMed ID: 16508085
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
Kahn BB, Alquier T, Carling D, Hardie DG
Cell Metab. 2005
PubMed ID: 16054041
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
The AMP-activated protein kinase pathway--new players upstream and downstream.
Hardie DG
J Cell Sci. 2004
PubMed ID: 15509864
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Genomic analysis of mouse retinal development.
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
PLoS Biol. 2004
PubMed ID: 15226823
Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy.
Irobi J, Van Impe K, Seeman P, Jordanova A, Dierick I, Verpoorten N, Michalik A, De Vriendt E, Jacobs A, Van Gerwen V, Vennekens K, Mazanec R, Tournev I, Hilton-Jones D, Talbot K, Kremensky I, Van Den Bosch L, Robberecht W, Van Vandekerckhove J, Van Broeckhoven C, Gettemans J, De Jonghe P, Timmerman V
Nat Genet. 2004
PubMed ID: 15122253
Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase: a new mechanism of action of insulin-sensitizing drugs.
Pilon G, Dallaire P, Marette A
J Biol Chem. 2004
PubMed ID: 14985344
C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase.
Kim EK, Miller I, Aja S, Landree LE, Pinn M, McFadden J, Kuhajda FP, Moran TH, Ronnett GV
J Biol Chem. 2004
PubMed ID: 15028725
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.
Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferré P, Birnbaum MJ, Stuck BJ, Kahn BB
Nature. 2004
PubMed ID: 15058305
AMP-activated protein kinase plays a role in the control of food intake.
Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, Carling D, Small CJ
J Biol Chem. 2004
PubMed ID: 14742438
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14985505
C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism.
Landree LE, Hanlon AL, Strong DW, Rumbaugh G, Miller IM, Thupari JN, Connolly EC, Huganir RL, Richardson C, Witters LA, Kuhajda FP, Ronnett GV
J Biol Chem. 2004
PubMed ID: 14615481
The AMP-activated protein kinase cascade--a unifying system for energy control.
Carling D
Trends Biochem Sci. 2004
PubMed ID: 14729328
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
TSC2 mediates cellular energy response to control cell growth and survival.
Inoki K, Zhu T, Guan KL
Cell. 2003
PubMed ID: 14651849
The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle.
Lemieux K, Konrad D, Klip A, Marette A
FASEB J. 2003
PubMed ID: 12958172
Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis.
Woods A, Vertommen D, Neumann D, Turk R, Bayliss J, Schlattner U, Wallimann T, Carling D, Rider MH
J Biol Chem. 2003
PubMed ID: 12764152
Management of cellular energy by the AMP-activated protein kinase system.
Hardie DG, Scott JW, Pan DA, Hudson ER
FEBS Lett. 2003
PubMed ID: 12829246
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.
Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG
J Biol. 2003
PubMed ID: 14511394
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization.
Warden SM, Richardson C, O'Donnell J, Stapleton D, Kemp BE, Witters LA
Biochem J. 2001
PubMed ID: 11171104
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.
Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D
Biochem J. 2000
PubMed ID: 10698692
Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle.
Chen Z, Heierhorst J, Mann RJ, Mitchelhill KI, Michell BJ, Witters LA, Lynch GS, Kemp BE, Stapleton D
FEBS Lett. 1999
PubMed ID: 10544261
Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system.
Turnley AM, Stapleton D, Mann RJ, Witters LA, Kemp BE, Bartlett PF
J Neurochem. 1999
PubMed ID: 10098881
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle.
Thornton C, Snowden MA, Carling D
J Biol Chem. 1998
PubMed ID: 9575201
Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit.
Mitchelhill KI, Michell BJ, House CM, Stapleton D, Dyck J, Gamble J, Ullrich C, Witters LA, Kemp BE
J Biol Chem. 1997
PubMed ID: 9305909
AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.
Stapleton D, Woollatt E, Mitchelhill KI, Nicholl JK, Fernandez CS, Michell BJ, Witters LA, Power DA, Sutherland GR, Kemp BE
FEBS Lett. 1997
PubMed ID: 9224708
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits.
Dyck JR, Gao G, Widmer J, Stapleton D, Fernandez CS, Kemp BE, Witters LA
J Biol Chem. 1996
PubMed ID: 8663446
Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro.
Woods A, Cheung PC, Smith FC, Davison MD, Scott J, Beri RK, Carling D
J Biol Chem. 1996
PubMed ID: 8626596
Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase.
Gao G, Fernandez CS, Stapleton D, Auster AS, Widmer J, Dyck JR, Kemp BE, Witters LA
J Biol Chem. 1996
PubMed ID: 8621499
Mammalian AMP-activated protein kinase subfamily.
Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE
J Biol Chem. 1996
PubMed ID: 8557660
Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase.
Stapleton D, Gao G, Michell BJ, Widmer J, Mitchelhill K, Teh T, House CM, Witters LA, Kemp BE
J Biol Chem. 1994
PubMed ID: 7961907

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	5564	19079	83803
EnsEMBL Gene(s)	ENSG00000111725	ENSMUSG00000029513	ENSRNOG00000001142
Unigene	Hs.726001	Mm.458152	Rn.3619
Homologene	PRKAB1	Prkab1	Prkab1
OMIM	602740	N/A	N/A
GeneCards	PRKAB1	N/A	N/A
Beta Cell Genomics	DT.219613 DT.95099394	DT.534614	N/A
Reactome	Q9Y478	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	5564	19079	83803

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
PRKAB1	HDAC5	BioGRID	empirical	18184930
PRKAB1	PDIA6	IntAct	empirical	17353931
PRKAB1	TRIM28	IntAct	empirical	17353931
PRKAB1	PSMD14	IntAct	empirical	17353931
PRKAB1	SF3A1	IntAct	empirical	17353931
PRKAB1	EIF3M	IntAct	empirical	17353931
PRKAB1	SYNCRIP	IntAct	empirical	17353931
PRKAB1	MYL12A	IntAct	empirical	17353931
PRKAB1	NUDC	IntAct	empirical	17353931
PRKAB1	RUVBL2	IntAct	empirical	17353931
PRKAB1	RCC1	IntAct	empirical	17353931
PRKAB1	HNRNPUL1	IntAct	empirical	17353931
PRKAB1	CDC37	IntAct	empirical	17353931
PRKAB1	NUDT5	IntAct	empirical	17353931
PRKAB1	STRAP	IntAct	empirical	17353931
PRKAB1	DDX20	IntAct	empirical	17353931
PRKAB1	WBSCR22	IntAct	empirical	17353931
PRKAB1	CIDEA	MINT	empirical	18480843
PRKAB1	CLTC	IntAct	empirical	17353931
PRKAB1	TARSL2	IntAct	empirical	17353931
PRKAB1	MTPN	IntAct	empirical	17353931
PRKAB1	PARP1	IntAct	empirical	17353931
PRKAB1	SLC25A10	IntAct	empirical	17353931
PRKAB1	CTPS	IntAct	empirical	17353931
PRKAB1	DDB1	IntAct	empirical	17353931
PRKAB1	DHX36	IntAct, BioGRID	empirical	17353931
PRKAB1	CYB5R3	IntAct	empirical	17353931
PRKAB1	AGL	HPRD	empirical	15886229
PRKAB1	DNM2	IntAct	empirical	17353931
PRKAB1	DSC1	BioGRID	empirical	20562859
PRKAB1	ECHS1	IntAct	empirical	17353931
PRKAB1	EEF1D	IntAct	empirical	17353931
PRKAB1	EIF2S3	IntAct	empirical	17353931
PRKAB1	EIF4G1	IntAct	empirical	17353931
PRKAB1	VMA21	IntAct	empirical	17353931
PRKAB1	ERH	IntAct	empirical	17353931
PRKAB1	ETFA	IntAct	empirical	17353931
PRKAB1	EWSR1	IntAct	empirical	17353931
PRKAB1	F10	HPRD, MINT, IntAct, BioGRID	empirical	16169070
PRKAB1	FABP5	IntAct	empirical	17353931
PRKAB1	FH	IntAct	empirical	17353931
PRKAB1	FHL1	IntAct	empirical	17353931
PRKAB1	HSPA4L	IntAct	empirical	17353931
PRKAB1	ABCF1	IntAct	empirical	17353931
PRKAB1	SNRNP200	IntAct, BioGRID	empirical	17353931
PRKAB1	COTL1	IntAct	empirical	17353931
PRKAB1	CASP14	IntAct, BioGRID	empirical	20562859
PRKAB1	RPL36	IntAct	empirical	17353931
PRKAB1	GDI2	IntAct	empirical	17353931
PRKAB1	PABPC1	IntAct	empirical	17353931
PRKAB1	CACYBP	IntAct	empirical	17353931
PRKAB1	EIF3K	IntAct	empirical	17353931
PRKAB1	GOT2	IntAct	empirical	17353931
PRKAB1	FAM98B	IntAct	empirical	17353931
PRKAB1	GRB2	IntAct, BioGRID	empirical	18624398
PRKAB1	CNIH4	IntAct	empirical	17353931
PRKAB1	NXT1	IntAct	empirical	17353931
PRKAB1	GSPT1	IntAct	empirical	17353931
PRKAB1	SEC61A1	IntAct	empirical	17353931
PRKAB1	GYS1	IntAct, BioGRID	empirical	17353931
PRKAB1	HADHA	IntAct	empirical	17353931
PRKAB1	HPRT1	IntAct	empirical	17353931
PRKAB1	EIF3E	IntAct	empirical	17353931
PRKAB1	EIF6	IntAct	empirical	17353931
PRKAB1	KIF5B	IntAct	empirical	17353931
PRKAB1	ACAT2	IntAct	empirical	17353931
PRKAB1	MARS	IntAct, BioGRID	empirical	17353931
PRKAB1	MAT2A	IntAct	empirical	17353931
PRKAB1	MCM5	IntAct	empirical	17353931
PRKAB1	MCM7	IntAct	empirical	17353931
PRKAB1	MIF	IntAct	empirical	17353931
PRKAB1	MSN	IntAct	empirical	17353931
PRKAB1	MYH10	IntAct, BioGRID	empirical	17353931
PRKAB1	ACLY	IntAct, BioGRID	empirical	17353931
PRKAB1	NDUFA7	HPRD, MINT, IntAct, BioGRID	empirical	16169070
PRKAB1	NSF	IntAct, BioGRID	empirical	20562859
PRKAB1	OAT	IntAct	empirical	17353931
PRKAB1	PA2G4	IntAct	empirical	17353931
PRKAB1	PAFAH1B2	IntAct	empirical	17353931
PRKAB1	MRPS16	IntAct	empirical	17353931
PRKAB1	PRKAG2	HPRD, IntAct, BioGRID, Reactome	empirical	10698692 20562859 15579580 11018120 14511394 14985505 14614828 8779952 8549768 16943194
PRKAB1	TRMT112	IntAct	empirical	17353931
PRKAB1	UFM1	IntAct	empirical	17353931
PRKAB1	PDHA1	IntAct	empirical	17353931
PRKAB1	SF3B14	IntAct	empirical	17353931
PRKAB1	CMPK1	IntAct	empirical	17353931
PRKAB1	PFDN2	IntAct	empirical	17353931
PRKAB1	PFKP	IntAct	empirical	17353931
PRKAB1	PFN2	IntAct	empirical	17353931
PRKAB1	PGD	IntAct	empirical	17353931
PRKAB1	PIN1	IntAct	empirical	17353931
PRKAB1	PLP2	IntAct	empirical	17353931
PRKAB1	PRKAG3	BioGRID, Reactome	empirical	10698692 15579580 11018120 14511394 14985505 14614828 8779952 8549768 16943194
PRKAB1	ATP5O	IntAct	empirical	17353931
PRKAB1	CYCS	IntAct	empirical	17353931
PRKAB1	QPCTL	IntAct	empirical	17353931
PRKAB1	EBLN2	IntAct	empirical	17353931
PRKAB1	RNMTL1	IntAct	empirical	17353931
PRKAB1	LRRC59	IntAct	empirical	17353931
PRKAB1	PREP	IntAct	empirical	17353931
PRKAB1	OTUB1	IntAct	empirical	17353931
PRKAB1	PRKAA1	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	8626596 8663446 18480843 16306228 20368287 20562859 15579580 11018120 14511394 14985505 14614828 8779952 8549768 16943194
PRKAB1	PRKAA2	HPRD, IntAct, BioGRID, Reactome	empirical	9224708 20562859 15579580 11018120 14511394 14985505 14614828 8779952 8549768 16943194
PRKAB1	PRKAB1	IntAct	empirical	20562859
PRKAB1	PRKAB2	IntAct, BioGRID	empirical	17353931 20562859
PRKAB1	CCDC88A	IntAct	empirical	17353931
PRKAB1	IPO9	IntAct	empirical	17353931
PRKAB1	PRKAG1	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	10698692 18480843 20562859 21988832 15579580 11018120 14511394 14985505 14614828 8779952 8549768 16943194
PRKAB1	TSR1	IntAct	empirical	17353931
PRKAB1	VPS35	IntAct	empirical	17353931
PRKAB1	CISD1	IntAct	empirical	17353931
PRKAB1	RCC2	IntAct	empirical	17353931
PRKAB1	MAPK6	BioGRID	empirical	21900206
PRKAB1	BCCIP	IntAct	empirical	17353931
PRKAB1	PSMA6	IntAct	empirical	17353931
PRKAB1	PSMA7	IntAct	empirical	17353931
PRKAB1	PSMB3	IntAct	empirical	17353931
PRKAB1	PSMC3	IntAct	empirical	17353931
PRKAB1	PSMC4	IntAct	empirical	17353931
PRKAB1	PSMD1	IntAct	empirical	17353931
PRKAB1	RTN4	IntAct	empirical	17353931
PRKAB1	EPB41L5	IntAct	empirical	17353931
PRKAB1	RANGAP1	IntAct	empirical	17353931
PRKAB1	RPL3	IntAct	empirical	17353931
PRKAB1	RPL31	IntAct	empirical	17353931
PRKAB1	RPL35A	IntAct	empirical	17353931
PRKAB1	RPS9	IntAct	empirical	17353931
PRKAB1	RRM1	IntAct	empirical	17353931
PRKAB1	SET	IntAct	empirical	17353931
PRKAB1	SHMT2	IntAct	empirical	17353931
PRKAB1	FSCN1	IntAct	empirical	17353931
PRKAB1	SRP14	IntAct	empirical	17353931
PRKAB1	SSB	IntAct	empirical	17353931
PRKAB1	SSR4	IntAct	empirical	17353931
PRKAB1	ST13	IntAct	empirical	17353931
PRKAB1	TARS	IntAct	empirical	17353931
PRKAB1	TGM3	IntAct, BioGRID	empirical	20562859
PRKAB1	TSN	IntAct	empirical	17353931
PRKAB1	UBC	BioGRID	empirical	21139048 21890473
PRKAB1	UBE2D3	IntAct	empirical	17353931
PRKAB1	UBE2L3	IntAct	empirical	17353931
PRKAB1	UBE2N	IntAct	empirical	17353931
PRKAB1	EZR	IntAct, BioGRID	empirical	17353931
PRKAB1	CSDE1	IntAct	empirical	17353931
PRKAB1	RAB7A	IntAct	empirical	17353931
PRKAB1	GRPEL1	IntAct	empirical	17353931
PRKAB1	CDK5RAP3	IntAct	empirical	17353931
PRKAB1	USP5	IntAct	empirical	17353931
PRKAB1	CAPZA1	IntAct	empirical	17353931
PRKAB1	GRWD1	IntAct	empirical	17353931
PRKAB1	PCGF6	IntAct	empirical	17353931
PRKAB1	API5	IntAct	empirical	17353931
PRKAB1	PDXK	IntAct	empirical	17353931
PRKAB1	EIF3H	IntAct	empirical	17353931
PRKAB1	CBR1	IntAct, BioGRID	empirical	17353931 20562859
PRKAB1	GMPS	IntAct	empirical	17353931
PRKAB1	DDX21	IntAct	empirical	17353931
PRKAB1	COPB2	IntAct	empirical	17353931
PRKAB1	VAMP3	IntAct	empirical	17353931
PRKAB1	EFTUD2	IntAct	empirical	17353931
PRKAB1	NPEPPS	IntAct	empirical	17353931
PRKAB1	ATP5J2	IntAct	empirical	17353931
PRKAB1	PDIA4	IntAct	empirical	17353931
PRKAB1	FNIP1	BioGRID	empirical	17028174
PRKAB1	NUP93	IntAct	empirical	17353931
PRKAB1	ULK2	IntAct	empirical	20562859
PRKAB1	PSMD6	IntAct	empirical	17353931