PPP3CA

Summary Top Help

Gene Description:

protein phosphatase 3, catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isozyme

Synonyms:

PPP3CA, Calna1, CALN, CnA, AW413465, Calna, CALNA, AI841391, Ppp3ca, Caln, CN, 2900074D19Rik, CCN1, CNA1, PPP2B, CALNA1

Orthologs:

Human PPP3CA (protein-coding), Mouse Ppp3ca (protein-coding), Rat Ppp3ca (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 2

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Iddm3	Rat	chr2:197256223..242256223	45.00	281

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm33	Rat	chr2:214633709..247295816	32.66	170

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr4:101944566..102268637 (3247 kb) View in Genome Browser

(Mouse) NCBIM37 - chr3:136333088..136600691 (267.60 kb) View in Genome Browser

(Rat) RGSC3.4 - chr2:234130176..234409232 (2796 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PPP3CA:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PPP3CA:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 16

Biocarta: 14

Reactome: 2

NCI-Nature Pathway Interaction Database: 7

Gene Ontology: 36

Publications from PubMed Top Help

Type 1 Diabetes Publications: 5

Publications: 239

Calcineurin mediates the gonadotropin-releasing hormone effect on expression of both subunits of the follicle-stimulating hormone through distinct mechanisms.
Pnueli L, Luo M, Wang S, Naor Z, Melamed P
Mol Cell Biol. 2011
PubMed ID: 21986493
The effect of down regulation of calcineurin Aα by lentiviral vector-mediated RNAi on the biological behavior of small-cell lung cancer and its bone metastasis.
Ma NQ, Liu LL, Min J, Wang JW, Jiang WF, Liu Y, Feng YG, Su HC, Feng YM, Zhang HL
Clin Exp Metastasis. 2011
PubMed ID: 21785830
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Li S, Wang L, Berman M, Kong YY, Dorf ME
Immunity. 2011
PubMed ID: 21903422
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
Calcineurin selectively docks with the dynamin Ixb splice variant to regulate activity-dependent bulk endocytosis.
Xue J, Graham ME, Novelle AE, Sue N, Gray N, McNiven MA, Smillie KJ, Cousin MA, Robinson PJ
J Biol Chem. 2011
PubMed ID: 21730063
Changes in calcineurin message, enzyme activity and protein content in the spinal dorsal horn are associated with chronic constriction injury of the rat sciatic nerve.
Miletic G, Sullivan KM, Dodson AM, Lippitt JA, Schneider JA, Miletic V
Neuroscience. 2011
PubMed ID: 21596102
Calcium mediates glomerular filtration through calcineurin and mTORC2/Akt signaling.
Vassiliadis J, Bracken C, Matthews D, O'Brien S, Schiavi S, Wawersik S
J Am Soc Nephrol. 2011
PubMed ID: 21784900
Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis.
Le Masson F, Razak Z, Kaigo M, Audouard C, Charry C, Cooke H, Westwood JT, Christians ES
Mol Cell Biol. 2011
PubMed ID: 21690297
Dephosphorylation of Bcl-10 by calcineurin is essential for canonical NF-κB activation in Th cells.
Frischbutter S, Gabriel C, Bendfeldt H, Radbruch A, Baumgrass R
Eur J Immunol. 2011
PubMed ID: 21674474
Are calcineurin genes associated with athletic status? A function, replication study.
He ZH, Hu Y, Li YC, Yvert T, Santiago C, Gómez-Gallego F, Ruiz JR, Lucia A
Med Sci Sports Exerc. 2011
PubMed ID: 21233773
Interaction of plasma membrane Ca(2+)-ATPase isoform 4 with calcineurin A: implications for catecholamine secretion by PC12 cells.
Kosiorek M, Podszywalow-Bartnicka P, Zylinska L, Zablocki K, Pikula S
Biochem Biophys Res Commun. 2011
PubMed ID: 21740891
Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells.
Cho JH, Kim HO, Webster K, Palendira M, Hahm B, Kim KS, King C, Tangye SG, Sprent J
Blood. 2011
PubMed ID: 21540458
Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes.
Dhandapany PS, Fabris F, Tonk R, Illaste A, Karakikes I, Sorourian M, Sheng J, Hajjar RJ, Tartaglia M, Sobie EA, Lebeche D, Gelb BD
J Mol Cell Cardiol. 2011
PubMed ID: 21440552
Myospryn is a calcineurin-interacting protein that negatively modulates slow-fiber-type transformation and skeletal muscle regeneration.
Kielbasa OM, Reynolds JG, Wu CL, Snyder CM, Cho MY, Weiler H, Kandarian S, Naya FJ
FASEB J. 2011
PubMed ID: 21427212
Isoform-specific dephosphorylation of dynamin1 by calcineurin couples neurotrophin receptor endocytosis to axonal growth.
Bodmer D, Ascaño M, Kuruvilla R
Neuron. 2011
PubMed ID: 21689596
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules.
Yamaguchi N, Chakraborty A, Pasek DA, Molkentin JD, Meissner G
Am J Physiol Heart Circ Physiol. 2011
PubMed ID: 21421818
Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.
Reddy RN, Pena JA, Roberts BR, Williams SR, Price SR, Gooch JL
Am J Pathol. 2011
PubMed ID: 21435446
Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heart.
Sachan N, Dey A, Rotter D, Grinsfelder DB, Battiprolu PK, Sikder D, Copeland V, Oh M, Bush E, Shelton JM, Bibb JA, Hill JA, Rothermel BA
Circ Res. 2011
PubMed ID: 21233454
Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain.
Spires-Jones TL, Kay K, Matsouka R, Rozkalne A, Betensky RA, Hyman BT
Neurosci Lett. 2011
PubMed ID: 20970476
Identification of differentially expressed genes in uveal melanoma using suppressive subtractive hybridization.
Landreville S, Lupien CB, Vigneault F, Gaudreault M, Mathieu M, Rousseau AP, Guérin SL, Salesse C
Mol Vis. 2011
PubMed ID: 21647268
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Sequential alterations in Akt, GSK3β, and calcineurin signalling in the mouse left ventricle after thoracic aortic constriction.
Prévilon M, Pezet M, Dachez C, Mercadier JJ, Rouet-Benzineb P
Can J Physiol Pharmacol. 2010
PubMed ID: 21076497
Hypothyroidism following developmental iodine deficiency reduces hippocampal neurogranin, CaMK II and calmodulin and elevates calcineurin in lactational rats.
Dong J, Liu W, Wang Y, Xi Q, Chen J
Int J Dev Neurosci. 2010
PubMed ID: 20654708
Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults.
He ZH, Hu Y, Li YC, Bao DP, Ruiz JR, Lucia A
Eur J Appl Physiol. 2010
PubMed ID: 20593291
Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B.
Bousette N, Chugh S, Fong V, Isserlin R, Kim KH, Volchuk A, Backx PH, Liu P, Kislinger T, MacLennan DH, Emili A, Gramolini AO
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20937869
Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.
Wang P, Mao Y, Razo J, Zhou X, Wong ST, Patel S, Elliott E, Shea E, Wu AH, Gaber AO
Pharmacogenomics. 2010
PubMed ID: 21047202
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases.
Mistafa O, Ghalali A, Kadekar S, Högberg J, Stenius U
J Biol Chem. 2010
PubMed ID: 20605778
The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses.
Sun T, Wu XS, Xu J, McNeil BD, Pang ZP, Yang W, Bai L, Qadri S, Molkentin JD, Yue DT, Wu LG
J Neurosci. 2010
PubMed ID: 20810903
Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D.
Zhu H, Suk HY, Yu RY, Brancho D, Olabisi O, Yang TT, Yang X, Zhang J, Moussaif M, Durand JL, Jelicks LA, Kim JY, Scherer PE, Frank PG, Lisanti MP, Calvert JW, Duranski MR, Lefer DJ, Huston E, Baillie GS, Houslay MD, Molkentin JD, Jin J, Chow CW
Mol Cell Biol. 2010
PubMed ID: 20647544
Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.
Chiocco MJ, Zhu X, Walther D, Pletnikova O, Troncoso JC, Uhl GR, Liu QR
Subst Use Misuse. 2010
PubMed ID: 20590401
Calcineurin signaling and PGC-1alpha expression are suppressed during muscle atrophy due to diabetes.
Roberts-Wilson TK, Reddy RN, Bailey JL, Zheng B, Ordas R, Gooch JL, Price SR
Biochim Biophys Acta. 2010
PubMed ID: 20359506
Increased expression of calpain and elevated activity of calcineurin in the myocardium of patients with congestive heart failure.
Yang D, Ma S, Tan Y, Li D, Tang B, Zhang X, Sun M, Yang Y
Int J Mol Med. 2010
PubMed ID: 20514436
Calcineurin mediates the angiotensin II-induced aldosterone synthesis in the adrenal glands by up-regulation of transcription of the CYP11B2 gene.
Yamashiro T, Kuge H, Zhang J, Honke K
J Biochem. 2010
PubMed ID: 20413672
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
Calcineurin promotes proliferation, migration, and invasion of small cell lung cancer.
Liu Y, Zhang Y, Min J, Liu LL, Ma NQ, Feng YM, Liu D, Wang PZ, Huang DD, Zhuang Y, Zhang HL
Tumour Biol. 2010
PubMed ID: 20422345
Role of calcineurin, hnRNPA2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets.
Guha M, Tang W, Sondheimer N, Avadhani NG
Biochim Biophys Acta. 2010
PubMed ID: 20153290
KChIP2 attenuates cardiac hypertrophy through regulation of Ito and intracellular calcium signaling.
Jin H, Hadri L, Palomeque J, Morel C, Karakikes I, Kaprielian R, Hajjar R, Lebeche D
J Mol Cell Cardiol. 2010
PubMed ID: 20051248
A salutary role for calcineurin in the heart.
Muslin AJ
J Mol Cell Cardiol. 2010
PubMed ID: 19879877
Calcineurin protects the heart in a murine model of dilated cardiomyopathy.
Heineke J, Wollert KC, Osinska H, Sargent MA, York AJ, Robbins J, Molkentin JD
J Mol Cell Cardiol. 2010
PubMed ID: 19854199
Cross-talk between calcineurin/NFAT and Jak/STAT signalling induces cardioprotective alphaB-crystallin gene expression in response to hypertrophic stimuli.
Manukyan I, Galatioto J, Mascareno E, Bhaduri S, Siddiqui MA
J Cell Mol Med. 2010
PubMed ID: 19538478
The role of RANTES as a crucial downstream cytokine in calcineurin-dependent VSMC apoptosis stimulated by INFgamma and CD40L.
Peng YD, Cheng LX, Zeng QT, Shi Y, Bao XX, Mao XB, Ji QW, Li SN, Guo M, Liang ZS, Wu TC
Cell Biol Int. 2010
PubMed ID: 20132097
TRPC channels are necessary mediators of pathologic cardiac hypertrophy.
Wu X, Eder P, Chang B, Molkentin JD
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20351294
Biological Pathway-Based Genome-Wide Association Analysis Identified the Vasoactive Intestinal Peptide (VIP) Pathway Important for Obesity.
Liu YJ, Guo YF, Zhang LS, Pei YF, Yu N, Yu P, Papasian CJ, Deng HW
Obesity (Silver Spring). 2010
PubMed ID: 20379146
Immunopotentiation on murine spleen lymphocytes induced by polysaccharide fraction of Panax ginseng via upregulating calcineurin activity.
Zhang SD, Yin YX, Wei Q
APMIS. 2010
PubMed ID: 20402674
The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin.
Li J, Negro A, Lopez J, Bauman AL, Henson E, Dodge-Kafka K, Kapiloff MS
J Mol Cell Cardiol. 2010
PubMed ID: 19883655
Are calcineurin genes associated with endurance phenotype traits?
He ZH, Hu Y, Wang HY, Li YC, Lu YL, Zhang L, Bao BP, Ruiz JR, Lucia A
Eur J Appl Physiol. 2010
PubMed ID: 20107831
Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation.
Amato R, Pinelli M, Monticelli A, Miele G, Cocozza S
BMC Evol Biol. 2010
PubMed ID: 21070662
Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs.
Bollo M, Paredes RM, Holstein D, Zheleznova N, Camacho P, Lechleiter JD
PLoS One. 2010
PubMed ID: 20700529
Inhibition of calcineurin phosphatase promotes exocytosis of renin from juxtaglomerular cells.
Madsen K, Friis UG, Gooch JL, Hansen PB, Holmgaard L, Skøtt O, Jensen BL
Kidney Int. 2010
PubMed ID: 19907416
Calcineurin activates interleukin-6 transcription in mouse skeletal muscle in vivo and in C2C12 myotubes in vitro.
Allen DL, Uyenishi JJ, Cleary AS, Mehan RS, Lindsay SF, Reed JM
Am J Physiol Regul Integr Comp Physiol. 2010
PubMed ID: 19907005
Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity.
Jiang LQ, Garcia-Roves PM, de Castro Barbosa T, Zierath JR
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 19861587
Expression of protein phosphatase 2B (calcineurin) subunit A isoforms in rat hippocampus after traumatic brain injury.
Bales JW, Ma X, Yan HQ, Jenkins LW, Dixon CE
J Neurotrauma. 2010
PubMed ID: 19751097
Loss of calcineurin Aalpha alters keratinocyte survival and differentiation.
Pena JA, Losi-Sasaki JL, Gooch JL
J Invest Dermatol. 2010
PubMed ID: 19626032
Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development.
Scott NJ, Ellmers LJ, Lainchbury JG, Maeda N, Smithies O, Richards AM, Cameron VA
Biochim Biophys Acta. 2009
PubMed ID: 19782130
Angiotensin II type 1 receptor-associated protein prevents vascular smooth muscle cell senescence via inactivation of calcineurin/nuclear factor of activated T cells pathway.
Min LJ, Mogi M, Tamura K, Iwanami J, Sakata A, Fujita T, Tsukuda K, Jing F, Iwai M, Horiuchi M
J Mol Cell Cardiol. 2009
PubMed ID: 19769983
Calcineurin deficiency decreases inflammatory lesions in transforming growth factor beta1-deficient mice.
Bommireddy R, Bueno OF, Martin J, Ormsby I, Chen H, Gard C, Molkentin JD, Boivin GP, Babcock GF, Doetschman T
Clin Exp Immunol. 2009
PubMed ID: 19747209
Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.
Xifró X, Giralt A, Saavedra A, García-Martínez JM, Díaz-Hernández M, Lucas JJ, Alberch J, Pérez-Navarro E
Neurobiol Dis. 2009
PubMed ID: 19733666
Protease activation during in vivo pancreatitis is dependent on calcineurin activation.
Shah AU, Sarwar A, Orabi AI, Gautam S, Grant WM, Park AJ, Shah AU, Liu J, Mistry PK, Jain D, Husain SZ
Am J Physiol Gastrointest Liver Physiol. 2009
PubMed ID: 20501444
Expression and activities of N-myristoyltransferase and calcineurin in normal and inflamed lungs.
Charavaryamath C, Lemieux H, Singh Suri S, Selvakumar P, Sharma RK, Singh B
Exp Lung Res. 2009
PubMed ID: 19916857
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cgamma1 and inhibition of calcineurin.
Hayashi H, Campenot RB, Vance DE, Vance JE
J Biol Chem. 2009
PubMed ID: 19717566
Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling.
Zeini M, Hang CT, Lehrer-Graiwer J, Dao T, Zhou B, Chang CP
Development. 2009
PubMed ID: 19710169
Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel.
Tandan S, Wang Y, Wang TT, Jiang N, Hall DD, Hell JW, Luo X, Rothermel BA, Hill JA
Circ Res. 2009
PubMed ID: 19478199
Calcineurin/NFAT pathway: a novel regulator of parturition.
Tabata C, Ogita K, Sato K, Nakamura H, Qing Z, Negoro H, Kumasawa K, Temma-Asano K, Tsutsui T, Nishimori K, Kimura T
Am J Reprod Immunol. 2009
PubMed ID: 19527231
Peroxisome proliferator-activated receptor beta stimulation induces rapid cardiac growth and angiogenesis via direct activation of calcineurin.
Wagner N, Jehl-Piétri C, Lopez P, Murdaca J, Giordano C, Schwartz C, Gounon P, Hatem SN, Grimaldi P, Wagner KD
Cardiovasc Res. 2009
PubMed ID: 19351742
Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway.
Courtwright A, Siamakpour-Reihani S, Arbiser JL, Banet N, Hilliard E, Fried L, Livasy C, Ketelsen D, Nepal DB, Perou CM, Patterson C, Klauber-Demore N
Cancer Res. 2009
PubMed ID: 19458075
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Calcineurin activates cytoglobin transcription in hypoxic myocytes.
Singh S, Manda SM, Sikder D, Birrer MJ, Rothermel BA, Garry DJ, Mammen PP
J Biol Chem. 2009
PubMed ID: 19203999
A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.
Rodríguez A, Roy J, Martínez-Martínez S, López-Maderuelo MD, Niño-Moreno P, Ortí L, Pantoja-Uceda D, Pineda-Lucena A, Cyert MS, Redondo JM
Mol Cell. 2009
PubMed ID: 19285944
The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding.
Kilka S, Erdmann F, Migdoll A, Fischer G, Weiwad M
Biochemistry. 2009
PubMed ID: 19154138
TGF-beta upregulation drives tertiary lymphoid organ formation and kidney dysfunction in calcineurin A-alpha heterozygous mice.
Kelly FM, Reddy RN, Roberts BR, Gangappa S, Williams IR, Gooch JL
Am J Physiol Renal Physiol. 2009
PubMed ID: 19129256
Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.
Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Marangoni S, Novello JC, Maccarrone G, Turck CW, Dias-Neto E
J Neural Transm. 2009
PubMed ID: 19034380
Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.
Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS, Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T, Scott HS
Genome Biol. 2009
PubMed ID: 19799774
Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.
Sandebring A, Thomas KJ, Beilina A, van der Brug M, Cleland MM, Ahmad R, Miller DW, Zambrano I, Cowburn RF, Behbahani H, Cedazo-Mínguez A, Cookson MR
PLoS One. 2009
PubMed ID: 19492085
A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart.
Kalsotra A, Xiao X, Ward AJ, Castle JC, Johnson JM, Burge CB, Cooper TA
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19075228
Human protein factory for converting the transcriptome into an in vitro-expressed proteome,.
Goshima N, Kawamura Y, Fukumoto A, Miura A, Honma R, Satoh R, Wakamatsu A, Yamamoto J, Kimura K, Nishikawa T, Andoh T, Iida Y, Ishikawa K, Ito E, Kagawa N, Kaminaga C, Kanehori K, Kawakami B, Kenmochi K, Kimura R, Kobayashi M, Kuroita T, Kuwayama H, Maruyama Y, Matsuo K, Minami K, Mitsubori M, Mori M, Morishita R, Murase A, Nishikawa A, Nishikawa S, Okamoto T, Sakagami N, Sakamoto Y, Sasaki Y, Seki T, Sono S, Sugiyama A, Sumiya T, Takayama T, Takayama Y, Takeda H, Togashi T, Yahata K, Yamada H, Yanagisawa Y, Endo Y, Imamoto F, Kisu Y, Tanaka S, Isogai T, Imai J, Watanabe S, Nomura N
Nat Methods. 2008
PubMed ID: 19054851
Tau binds both subunits of calcineurin, and binding is impaired by calmodulin.
Yu DY, Tong L, Song GJ, Lin WL, Zhang LQ, Bai W, Gong H, Yin YX, Wei Q
Biochim Biophys Acta. 2008
PubMed ID: 18639592
CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells.
Li GD, Zhang X, Li R, Wang YD, Wang YL, Han KJ, Qian XP, Yang CG, Liu P, Wei Q, Chen WF, Zhang J, Zhang Y
J Biol Chem. 2008
PubMed ID: 18815128
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.
Cereghetti GM, Stangherlin A, Martins de Brito O, Chang CR, Blackstone C, Bernardi P, Scorrano L
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18838687
Activation of peroxisome proliferator-activated receptor gamma inhibits endothelin-1-induced cardiac hypertrophy via the calcineurin/NFAT signaling pathway.
Bao Y, Li R, Jiang J, Cai B, Gao J, Le K, Zhang F, Chen S, Liu P
Mol Cell Biochem. 2008
PubMed ID: 18600431
Blockade of calcineurin reverses cardiac hypertrophy and induces the down-regulation of JNK mRNA expression in renovascular hypertensive rats.
Hongzhuan Sheng, Jianhua Zhu, Xiaohui Wu, Jinan Zhang
J Renin Angiotensin Aldosterone Syst. 2008
PubMed ID: 18957384
Influence of AMP-activated protein kinase and calcineurin on metabolic networks in skeletal muscle.
Long YC, Zierath JR
Am J Physiol Endocrinol Metab. 2008
PubMed ID: 18544643
Interleukin-3 (IL-3)-induced c-fos activation is modulated by Gab2-calcineurin interaction.
Pyarajan S, Matejovic G, Pratt JC, Baksh S, Burakoff SJ
J Biol Chem. 2008
PubMed ID: 18586679
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
Lipopolysaccharide induces cellular hypertrophy through calcineurin/NFAT-3 signaling pathway in H9c2 myocardiac cells.
Liu CJ, Cheng YC, Lee KW, Hsu HH, Chu CH, Tsai FJ, Tsai CH, Chu CY, Liu JY, Kuo WW, Huang CY
Mol Cell Biochem. 2008
PubMed ID: 18398669
The secondary structure of calcineurin regulatory region and conformational change induced by calcium/calmodulin binding.
Shen X, Li H, Ou Y, Tao W, Dong A, Kong J, Ji C, Yu S
J Biol Chem. 2008
PubMed ID: 18296442
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Stimulation of calcineurin A{alpha} activity attenuates muscle pathophysiology in mdx dystrophic mice.
Stupka N, Schertzer JD, Bassel-Duby R, Olson EN, Lynch GS
Am J Physiol Regul Integr Comp Physiol. 2008
PubMed ID: 18199592
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease.
Li Y, Rowland C, Xiromerisiou G, Lagier RJ, Schrodi SJ, Dradiotis E, Ross D, Bui N, Catanese J, Aggelakis K, Grupe A, Hadjigeorgiou G
PLoS ONE. 2008
PubMed ID: 18628988
Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo.
Gurda GT, Guo L, Lee SH, Molkentin JD, Williams JA
Mol Biol Cell. 2008
PubMed ID: 17978097
A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration.
Lara-Pezzi E, Winn N, Paul A, McCullagh K, Slominsky E, Santini MP, Mourkioti F, Sarathchandra P, Fukushima S, Suzuki K, Rosenthal N
J Cell Biol. 2007
PubMed ID: 18086917
The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning.
Kurrasch DM, Cheung CC, Lee FY, Tran PV, Hata K, Ingraham HA
J Neurosci. 2007
PubMed ID: 18077674
Developmental regulation of calcineurin isoforms in the rodent kidney: association with COX-2.
Liu H, Ye W, Guan G, Dong Z, Jia Z, Yang T
Am J Physiol Renal Physiol. 2007
PubMed ID: 17881460
FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice.
Martin LJ, Chen H, Liao X, Allayee H, Shih DM, Lee GS, Hovland DN, Robbins WA, Carnes K, Hess RA, Lusis AJ, Collins MD
Toxicol Sci. 2007
PubMed ID: 17785681
Calcineurin negatively regulates TLR-mediated activation pathways.
Kang YJ, Kusler B, Otsuka M, Hughes M, Suzuki N, Suzuki S, Yeh WC, Akira S, Han J, Jones PP
J Immunol. 2007
PubMed ID: 17878357
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons.
Faure C, Corvol JC, Toutant M, Valjent E, Hvalby O, Jensen V, El Messari S, Corsi JM, Kadaré G, Girault JA
J Cell Sci. 2007
PubMed ID: 17684059
Calcineurin differentially regulates fast myosin heavy chain genes in oxidative muscle fibre type conversion.
da Costa N, Edgar J, Ooi PT, Su Y, Meissner JD, Chang KC
Cell Tissue Res. 2007
PubMed ID: 17587059
Calcineurin in reactive astrocytes plays a key role in the interplay between proinflammatory and anti-inflammatory signals.
Fernandez AM, Fernandez S, Carrero P, Garcia-Garcia M, Torres-Aleman I
J Neurosci. 2007
PubMed ID: 17699657
Calcineurin-A alpha activation enhances the structure and function of regenerating muscles after myotoxic injury.
Stupka N, Schertzer JD, Bassel-Duby R, Olson EN, Lynch GS
Am J Physiol Regul Integr Comp Physiol. 2007
PubMed ID: 17475677
Calcineurin activation is only one calcium-dependent step in cytotoxic T lymphocyte granule exocytosis.
Grybko MJ, Bartnik JP, Wurth GA, Pores-Fernando AT, Zweifach A
J Biol Chem. 2007
PubMed ID: 17478429
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
Wu C, Ma MH, Brown KR, Geisler M, Li L, Tzeng E, Jia CY, Jurisica I, Li SS
Proteomics. 2007
PubMed ID: 17474147
Nuclear translocation of calcineurin Abeta but not calcineurin Aalpha by platelet-derived growth factor in rat aortic smooth muscle.
Jabr RI, Wilson AJ, Riddervold MH, Jenkins AH, Perrino BA, Clapp LH
Am J Physiol Cell Physiol. 2007
PubMed ID: 17303652
Developmental regulation of the mouse IGF-I exon 1 promoter region by calcineurin activation of NFAT in skeletal muscle.
Alfieri CM, Evans-Anderson HJ, Yutzey KE
Am J Physiol Cell Physiol. 2007
PubMed ID: 17229811
Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses.
Rebola N, Sachidhanandam S, Perrais D, Cunha RA, Mulle C
J Neurosci. 2007
PubMed ID: 17428973
Calcineurin mediates acetylcholinesterase expression during calcium ionophore A23187-induced HeLa cell apoptosis.
Zhu H, Gao W, Jiang H, Wu J, Shi YF, Zhang XJ
Biochim Biophys Acta. 2007
PubMed ID: 17320203
Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition.
Yang XY, Yang TT, Schubert W, Factor SM, Chow CW
Dev Biol. 2007
PubMed ID: 17198697
Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM
Mol Cell Proteomics. 2007
PubMed ID: 17114649
The full-ORF clone resource of the German cDNA Consortium.
Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blöcker H, Heubner D, Hoerlein A, Michel G, Wedler H, Köhrer K, Ottenwälder B, Poustka A, Wiemann S, Schupp I
BMC Genomics. 2007
PubMed ID: 17974005
Ectopic expression of the homeobox gene Cux-1 rescues calcineurin inhibition in mouse embryonic kidney cultures.
Alcalay NI, Brantley JG, Sharma M, Gooch JL, Vanden Heuvel GB
Dev Dyn. 2007
PubMed ID: 17072859
Inhibition of nuclear import of calcineurin prevents myocardial hypertrophy.
Hallhuber M, Burkard N, Wu R, Buch MH, Engelhardt S, Hein L, Neyses L, Schuh K, Ritter O
Circ Res. 2006
PubMed ID: 16931796
Cyclosporin A inhibits hypoxia-induced pulmonary hypertension and right ventricle hypertrophy.
Koulmann N, Novel-Chaté V, Peinnequin A, Chapot R, Serrurier B, Simler N, Richard H, Ventura-Clapier R, Bigard X
Am J Respir Crit Care Med. 2006
PubMed ID: 16799071
Activated calcineurin ameliorates contraction-induced injury to skeletal muscles of mdx dystrophic mice.
Stupka N, Plant DR, Schertzer JD, Emerson TM, Bassel-Duby R, Olson EN, Lynch GS
J Physiol. 2006
PubMed ID: 16793906
PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum.
Lin SS, Bassik MC, Suh H, Nishino M, Arroyo JD, Hahn WC, Korsmeyer SJ, Roberts TM
J Biol Chem. 2006
PubMed ID: 16717086
Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease.
Sacksteder CA, Qian WJ, Knyushko TV, Wang H, Chin MH, Lacan G, Melega WP, Camp DG, Smith RD, Smith DJ, Squier TC, Bigelow DJ
Biochemistry. 2006
PubMed ID: 16800626
Loss of calcineurin Aalpha results in altered trafficking of AQP2 and in nephrogenic diabetes insipidus.
Gooch JL, Guler RL, Barnes JL, Toro JJ
J Cell Sci. 2006
PubMed ID: 16735444
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
The LIFEdb database in 2006.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S
Nucleic Acids Res. 2006
PubMed ID: 16381901
Calcineurin regulates bone formation by the osteoblast.
Sun L, Blair HC, Peng Y, Zaidi N, Adebanjo OA, Wu XB, Wu XY, Iqbal J, Epstein S, Abe E, Moonga BS, Zaidi M
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16286645
Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain.
Liu F, Grundke-Iqbal I, Iqbal K, Oda Y, Tomizawa K, Gong CX
J Biol Chem. 2005
PubMed ID: 16150694
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
Decreased activity and increased aggregation of brain calcineurin during aging.
Agbas A, Zaidi A, Michaelis EK
Brain Res. 2005
PubMed ID: 16150427
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucoma.
Huang W, Fileta JB, Dobberfuhl A, Filippopolous T, Guo Y, Kwon G, Grosskreutz CL
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16103353
The sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit.
Buch MH, Pickard A, Rodriguez A, Gillies S, Maass AH, Emerson M, Cartwright EJ, Williams JC, Oceandy D, Redondo JM, Neyses L, Armesilla AL
J Biol Chem. 2005
PubMed ID: 15955804
Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.
Oh M, Rybkin II, Copeland V, Czubryt MP, Shelton JM, van Rooij E, Richardson JA, Hill JA, De Windt LJ, Bassel-Duby R, Olson EN, Rothermel BA
Mol Cell Biol. 2005
PubMed ID: 16024798
Reversible blockade of experience-dependent plasticity by calcineurin in mouse visual cortex.
Yang Y, Fischer QS, Zhang Y, Baumgärtel K, Mansuy IM, Daw NW
Nat Neurosci. 2005
PubMed ID: 15880107
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
Nature. 2005
PubMed ID: 15815621
Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin.
Wang Y, Shibasaki F, Mizuno K
J Biol Chem. 2005
PubMed ID: 15671020
The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT.
Rodríguez A, Martínez-Martínez S, López-Maderuelo MD, Ortega-Pérez I, Redondo JM
J Biol Chem. 2005
PubMed ID: 15671033
A reassessment of the inhibitory capacity of human FKBP38 on calcineurin.
Weiwad M, Edlich F, Erdmann F, Jarczowski F, Kilka S, Dorn M, Pechstein A, Fischer G
FEBS Lett. 2005
PubMed ID: 15757646
Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc.
Heineke J, Ruetten H, Willenbockel C, Gross SC, Naguib M, Schaefer A, Kempf T, Hilfiker-Kleiner D, Caroni P, Kraft T, Kaiser RA, Molkentin JD, Drexler H, Wollert KC
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15665106
Retina-driven dephosphorylation of the NR2A subunit correlates with faster NMDA receptor kinetics at developing retinocollicular synapses.
Townsend M, Liu Y, Constantine-Paton M
J Neurosci. 2004
PubMed ID: 15590926
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress.
Frey N, Barrientos T, Shelton JM, Frank D, Rütten H, Gehring D, Kuhn C, Lutz M, Rothermel B, Bassel-Duby R, Richardson JA, Katus HA, Hill JA, Olson EN
Nat Med. 2004
PubMed ID: 15543153
Heart block in mice overexpressing calcineurin but not NF-AT3.
Gillis AM, Kavanagh KM, Mathison HJ, Somers JR, Zhan S, Duff HJ
Cardiovasc Res. 2004
PubMed ID: 15537502
Calcineurin A-alpha but not A-beta is required for normal kidney development and function.
Gooch JL, Toro JJ, Guler RL, Barnes JL
Am J Pathol. 2004
PubMed ID: 15509543
Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex.
Li HH, Kedar V, Zhang C, McDonough H, Arya R, Wang DZ, Patterson C
J Clin Invest. 2004
PubMed ID: 15489953
From ORFeome to biology: a functional genomics pipeline.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A
Genome Res. 2004
PubMed ID: 15489336
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Calcium-calcineurin signaling in the regulation of cardiac hypertrophy.
Wilkins BJ, Molkentin JD
Biochem Biophys Res Commun. 2004
PubMed ID: 15336966
Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy.
Parsons SA, Millay DP, Wilkins BJ, Bueno OF, Tsika GL, Neilson JR, Liberatore CM, Yutzey KE, Crabtree GR, Tsika RW, Molkentin JD
J Biol Chem. 2004
PubMed ID: 15082723
Differential expression of calcineurin A isoforms in the diabetic kidney.
Gooch JL, Pèrgola PE, Guler RL, Abboud HE, Barnes JL
J Am Soc Nephrol. 2004
PubMed ID: 15153553
Altered Bad localization and interaction between Bad and Bcl-xL in the hippocampus after transient global ischemia.
Abe T, Takagi N, Nakano M, Furuya M, Takeo S
Brain Res. 2004
PubMed ID: 15120593
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts.
Kahl CR, Means AR
Mol Biol Cell. 2004
PubMed ID: 14767060
Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates the expression of iNOS through IKK and NF-kappaB activity in LPS-stimulated mouse peritoneal macrophages and RAW 264.7 cells.
Kim Y, Moon JS, Lee KS, Park SY, Cheong J, Kang HS, Lee HY, Kim HD
Biochem Biophys Res Commun. 2004
PubMed ID: 14741691
Endotracheal calcineurin inhibition ameliorates injury in an experimental model of lung ischemia-reperfusion.
Woolley SM, Farivar AS, Naidu BV, Rosengart M, Thomas R, Fraga C, Mulligan MS
J Thorac Cardiovasc Surg. 2004
PubMed ID: 14762344
Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses.
Lee SY, Wenk MR, Kim Y, Nairn AC, De Camilli P
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14704270
Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy.
Wilkins BJ, Dai YS, Bueno OF, Parsons SA, Xu J, Plank DM, Jones F, Kimball TR, Molkentin JD
Circ Res. 2004
PubMed ID: 14656927
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.
Genescà L, Aubareda A, Fuentes JJ, Estivill X, De La Luna S, Pérez-Riba M
Biochem J. 2003
PubMed ID: 12809556
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia.
Miyakawa T, Leiter LM, Gerber DJ, Gainetdinov RR, Sotnikova TD, Zeng H, Caron MG, Tonegawa S
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12851457
Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle.
Afroze T, Yang LL, Wang C, Gros R, Kalair W, Hoque AN, Mungrue IN, Zhu Z, Husain M
Am J Physiol Cell Physiol. 2003
PubMed ID: 12660151
Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice.
Parsons SA, Wilkins BJ, Bueno OF, Molkentin JD
Mol Cell Biol. 2003
PubMed ID: 12773574
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.
Blagoev B, Kratchmarova I, Ong SE, Nielsen M, Foster LJ, Mann M
Nat Biotechnol. 2003
PubMed ID: 12577067
Regulation of NF-kappaB activation by protein phosphatase 2B and NO, via protein kinase A activity, in human monocytes.
Bengoechea-Alonso MT, Pelacho B, Osés-Prieto JA, Santiago E, López-Moratalla N, López-Zabalza MJ
Nitric Oxide. 2003
PubMed ID: 12586544
Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapses.
Wang J, Liu S, Haditsch U, Tu W, Cochrane K, Ahmadian G, Tran L, Paw J, Wang Y, Mansuy I, Salter MM, Lu YM
J Neurosci. 2003
PubMed ID: 12574411
Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy.
Vega RB, Rothermel BA, Weinheimer CJ, Kovacs A, Naseem RH, Bassel-Duby R, Williams RS, Olson EN
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12515860
Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue.
Erin N, Bronson SK, Billingsley ML
Neuroscience. 2003
PubMed ID: 12617961
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis.
Shirane M, Nakayama KI
Nat Cell Biol. 2003
PubMed ID: 12510191
Calcineurin is activated in diabetes and is required for glomerular hypertrophy and ECM accumulation.
Gooch JL, Barnes JL, Garcia S, Abboud HE
Am J Physiol Renal Physiol. 2003
PubMed ID: 12388427
Cardiac-specific expression of calcineurin reverses embryonic lethality in calreticulin-deficient mouse.
Guo L, Nakamura K, Lynch J, Opas M, Olson EN, Agellon LB, Michalak M
J Biol Chem. 2002
PubMed ID: 12377773
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E
Virology. 2002
PubMed ID: 12482669
Ca(2+)-dependent interaction between FKBP12 and calcineurin regulates activity of the Ca(2+) release channel in skeletal muscle.
Shin DW, Pan Z, Bandyopadhyay A, Bhat MB, Kim DH, Ma J
Biophys J. 2002
PubMed ID: 12414688
Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors.
Cao X, Kambe F, Miyazaki T, Sarkar D, Ohmori S, Seo H
Biochem J. 2002
PubMed ID: 12102656
Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes.
Huai Q, Kim HY, Liu Y, Zhao Y, Mondragon A, Liu JO, Ke H
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12218175
Multiple domains of MCIP1 contribute to inhibition of calcineurin activity.
Vega RB, Yang J, Rothermel BA, Bassel-Duby R, Williams RS
J Biol Chem. 2002
PubMed ID: 12063245
Protein kinase Czeta phosphorylates nuclear factor of activated T cells and regulates its transactivating activity.
San-Antonio B, Iñiguez MA, Fresno M
J Biol Chem. 2002
PubMed ID: 12021260
Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the alpha or beta catalytic subunit.
Perrino BA, Wilson AJ, Ellison P, Clapp LH
Eur J Biochem. 2002
PubMed ID: 12135494
Maintenance of muscle mass is not dependent on the calcineurin-NFAT pathway.
Dupont-Versteegden EE, Knox M, Gurley CM, Houlé JD, Peterson CA
Am J Physiol Cell Physiol. 2002
PubMed ID: 11997253
Decreased calcineurin and increased phosphothreonine-DARPP-32 in the striatum of rats behaviorally sensitized to methamphetamine.
Lin XH, Hashimoto T, Kitamura N, Murakami N, Shirakawa O, Maeda K
Synapse. 2002
PubMed ID: 11954050
Calcineurin Aalpha plays an exclusive role in TCR signaling in mature but not in immature T cells.
Chan VS, Wong C, Ohashi PS
Eur J Immunol. 2002
PubMed ID: 11981809
Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.
Frey N, Olson EN
J Biol Chem. 2002
PubMed ID: 11842093
Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo.
Antos CL, McKinsey TA, Frey N, Kutschke W, McAnally J, Shelton JM, Richardson JA, Hill JA, Olson EN
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11782539
Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory.
Zeng H, Chattarji S, Barbarosie M, Rondi-Reig L, Philpot BD, Miyakawa T, Bear MF, Tonegawa S
Cell. 2001
PubMed ID: 11733061
Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells.
Esau C, Boes M, Youn HD, Tatterson L, Liu JO, Chen J
J Exp Med. 2001
PubMed ID: 11714752
Superoxide dismutase mutations of familial amyotrophic lateral sclerosis and the oxidative inactivation of calcineurin.
Volkel H, Scholz M, Link J, Selzle M, Werner P, Tunnemann R, Jung G, Ludolph AC, Reuter A
FEBS Lett. 2001
PubMed ID: 11513882
Caspase-mediated calcineurin activation contributes to IL-2 release during T cell activation.
Mukerjee N, McGinnis KM, Gnegy ME, Wang KK
Biochem Biophys Res Commun. 2001
PubMed ID: 11478781
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.
Graef IA, Chen F, Chen L, Kuo A, Crabtree GR
Cell. 2001
PubMed ID: 11439183
Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes.
Lim HW, New L, Han J, Molkentin JD
J Biol Chem. 2001
PubMed ID: 11279073
Expression of ZAKI-4 messenger ribonucleic acid in the brain during rat development and the effect of hypothyroidism.
Siddiq A, Miyazaki T, Takagishi Y, Kanou Y, Hayasaka S, Inouye M, Seo H, Murata Y
Endocrinology. 2001
PubMed ID: 11316738
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.
Frey N, Richardson JA, Olson EN
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11114196
DNA cloning using in vitro site-specific recombination.
Hartley JL, Temple GF, Brasch MA
Genome Res. 2000
PubMed ID: 11076863
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Matching of calcineurin activity to upstream effectors is critical for skeletal muscle fiber growth.
Dunn SE, Chin ER, Michel RN
J Cell Biol. 2000
PubMed ID: 11062266
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Calcineurin: form and function.
Rusnak F, Mertz P
Physiol Rev. 2000
PubMed ID: 11015619
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways.
Fuentes JJ, Genescà L, Kingsbury TJ, Cunningham KW, Pérez-Riba M, Estivill X, de la Luna S
Hum Mol Genet. 2000
PubMed ID: 10861295
T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex.
Yamashita M, Katsumata M, Iwashima M, Kimura M, Shimizu C, Kamata T, Shin T, Seki N, Suzuki S, Taniguchi M, Nakayama T
J Exp Med. 2000
PubMed ID: 10839803
Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2.
Brogan IJ, Pravica V, Hutchinson IV
Transpl Immunol. 2000
PubMed ID: 11005320
Dissection of behavior and psychiatric disorders using the mouse as a model.
Tarantino LM, Bucan M
Hum Mol Genet. 2000
PubMed ID: 10767319
A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus.
Zhuo M, Zhang W, Son H, Mansuy I, Sobel RA, Seidman J, Kandel ER
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10200317
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC
Science. 1999
PubMed ID: 10195903
Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.
Crabtree GR
Cell. 1999
PubMed ID: 10089876
Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin.
Shih M, Lin F, Scott JD, Wang HY, Malbon CC
J Biol Chem. 1999
PubMed ID: 9880537
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region.
Kashishian A, Howard M, Loh C, Gallatin WM, Hoekstra MF, Lai Y
J Biol Chem. 1998
PubMed ID: 9765270
Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes.
Sun L, Youn HD, Loh C, Stolow M, He W, Liu JO
Immunity. 1998
PubMed ID: 9655484
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.
Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN
Cell. 1998
PubMed ID: 9568714
Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.
Mansuy IM, Mayford M, Jacob B, Kandel ER, Bach ME
Cell. 1998
PubMed ID: 9489698
Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin.
Winder DG, Mansuy IM, Osman M, Moallem TM, Kandel ER
Cell. 1998
PubMed ID: 9489697
Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2.
Shibasaki F, Kondo E, Akagi T, McKeon F
Nature. 1997
PubMed ID: 9109491
Cytoskeletal changes in the brains of mice lacking calcineurin A alpha.
Kayyali US, Zhang W, Yee AG, Seidman JG, Potter H
J Neurochem. 1997
PubMed ID: 9084440
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
T cell responses in calcineurin A alpha-deficient mice.
Zhang BW, Zimmer G, Chen J, Ladd D, Li E, Alt FW, Wiederrecht G, Cryan J, O'Neill EA, Seidman CE, Abbas AK, Seidman JG
J Exp Med. 1996
PubMed ID: 8627154
Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively.
Wang MG, Yi H, Guerini D, Klee CB, McBride OW
Cytogenet Cell Genet. 1996
PubMed ID: 8978785
Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.
Kissinger CR, Parge HE, Knighton DR, Lewis CT, Pelletier LA, Tempczyk A, Kalish VJ, Tucker KD, Showalter RE, Moomaw EW
Nature. 1995
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Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux.
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Cell. 1995
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Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.
Shibasaki F, McKeon F
J Cell Biol. 1995
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X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex.
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Cell. 1995
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Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells.
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Mol Cell Biol. 1995
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Association of protein kinase A and protein phosphatase 2B with a common anchoring protein.
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Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain.
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The Ca2+/calmodulin-activated, phosphoprotein phosphatase calcineurin is sufficient for positive transcriptional regulation of the mouse IL-4 gene.
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Int Immunol. 1994
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Chromosomal assignments of the genes for the calcineurin A alpha (Calna1) and A beta subunits (Calna2) in the rat.
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Cytogenet Cell Genet. 1994
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Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha).
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Biochim Biophys Acta. 1993
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Molecular cloning and characterization of the promoter region of the calcineurin A alpha gene.
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Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase.
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Characterization of the phosphatase activity of a baculovirus-expressed calcineurin A isoform.
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J Biol Chem. 1992
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Molecular and phylogenetic analysis of calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit genes.
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Multiplicity of protein serine-threonine phosphatases in PC12 pheochromocytoma and FTO-2B hepatoma cells.
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Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods.
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J Biol Chem. 1990
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Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.
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Proc Natl Acad Sci U S A. 1989
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The complete primary structure of calcineurin A, a calmodulin binding protein homologous with protein phosphatases 1 and 2A.
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Biochem Biophys Res Commun. 1989
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Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin.
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Proc Natl Acad Sci U S A. 1988
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Mammalian brain phosphoproteins as substrates for calcineurin.
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Model Organism Phenotype Links from MGI Top Help

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External Links Top Help

	Human	Mouse	Rat
Entrez Gene	5530	19055	24674
EnsEMBL Gene(s)	ENSG00000138814	ENSMUSG00000028161	ENSRNOG00000009882
Unigene	Hs.435512	Mm.331389	Rn.6866
Homologene	PPP3CA	Ppp3ca	Ppp3ca
OMIM	114105	N/A	N/A
GeneCards	PPP3CA	N/A	N/A
Beta Cell Genomics	DT.100816745 DT.91684424 DT.91758409 DT.99946684	DT.101409017 DT.101725256 DT.101725390 DT.535071 DT.87072611 DT.94347221	N/A
Reactome	Q08209	N/A	N/A
Plasma Peptide Atlas	ENSP00000320580	N/A	N/A
WikiGenes	5530	19055	24674

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Interactor	Interactor	Sources	Classification	Pubmed IDs
PPP3CA	RCAN2	HPRD	empirical	10861295 12102656
PPP3CA	DLG4	IntAct	empirical	19455133
PPP3CA	RCAN1	HPRD	empirical	10861295 12063245
PPP3CA	CRTC2	HPRD	empirical	15454081
PPP3CA	FKBP1A	HPRD	empirical	7543369 8524402
PPP3CA	CABIN1	HPRD	empirical	11714752
PPP3CA	FKBP8	HPRD	empirical	12510191 15757646
PPP3CA	ABL1	IntAct	empirical	17474147
PPP3CA	GABRA1	HPRD	empirical	12574411
PPP3CA	GABRB2	HPRD	empirical	12574411
PPP3CA	GABRG2	HPRD	empirical	12574411
PPP3CA	GRB2	IntAct	empirical	17474147 12577067
PPP3CA	GRIN1	MINT, IntAct	empirical	10862698 16635246
PPP3CA	GRIN2B	IntAct	empirical	10862698 16635246
PPP3CA	NR3C1	IntAct	empirical	20195357
PPP3CA	C16orf74	HPRD, MINT, IntAct	empirical	16189514
PPP3CA	ATP2B4	HPRD	empirical	15955804
PPP3CA	MYOZ2	HPRD	empirical	11842093
PPP3CA	PPP3CA	HPRD	empirical	12574411
PPP3CA	PPP3R1	HPRD, MINT, IntAct	empirical	11439183 8524402
PPP3CA	PRKCZ	HPRD	empirical	12021260
PPP3CA	BAD	HPRD	empirical	10195903
PPP3CA	BCL2	HPRD	empirical	9109491 7593193
PPP3CA	RXRB	IntAct	empirical	20195357
PPP3CA	SOD1	HPRD	empirical	11513882
PPP3CA	YWHAB	IntAct	empirical	16635246
PPP3CA	YWHAZ	IntAct	empirical	19562802
PPP3CA	CASP3	HPRD	empirical	11478781
PPP3CA	SYNJ1	HPRD, MINT	empirical	14704270
PPP3CA	NEURL	IntAct	empirical	22153079
PPP3CA	MYOZ3	HPRD	empirical	11842093
PPP3CA	AKAP5	HPRD	empirical	9765270 7528941