PPP2R1B

Summary Top Help

Gene Description:

protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform; protein phosphatase 2, regulatory subunit A, beta

Synonyms:

AI790395, Ppp2r1b, PP2A-Abeta, 2410091N08Rik, PPP2R1B, PR65B

Orthologs:

Human PPP2R1B (protein-coding), Mouse Ppp2r1b (protein-coding), Rat Ppp2r1b (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd2	Mouse	chr9:32308040..98698811	66.39	764	6 no lod score

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:111597632..111637169 (39.54 kb) View in Genome Browser

(Mouse) NCBIM37 - chr9:50653406..50702334 (48.93 kb) View in Genome Browser

(Rat) RGSC3.4 - chr8:54208126..54240250 (32.12 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PPP2R1B:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PPP2R1B:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 8

Biocarta: None available

Reactome: 31

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 2

Publications from PubMed Top Help

Publications: 70

Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Chromosome 11q23.1 is an unstable region in B-cell tumor cell lines.
Poretti G, Kwee I, Bernasconi B, Rancoita PM, Rinaldi A, Capella C, Zucca E, Neri A, Tibiletti MG, Bertoni F
Leuk Res. 2011
PubMed ID: 21420167
Protein phosphatase 2A catalytic subunit α (PP2Acα) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway.
Chen W, Gu P, Jiang X, Ruan HB, Li C, Gao X
Am J Pathol. 2011
PubMed ID: 21514445
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase.
Guenebeaud C, Goldschneider D, Castets M, Guix C, Chazot G, Delloye-Bourgeois C, Eisenberg-Lerner A, Shohat G, Zhang M, Laudet V, Kimchi A, Bernet A, Mehlen P
Mol Cell. 2010
PubMed ID: 21172653
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
Streamlined analysis schema for high-throughput identification of endogenous protein complexes.
Malovannaya A, Li Y, Bulynko Y, Jung SY, Wang Y, Lanz RB, O'Malley BW, Qin J
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133760
PR65, the HEAT-repeat scaffold of phosphatase PP2A, is an elastic connector that links force and catalysis.
Grinthal A, Adamovic I, Weiner B, Karplus M, Kleckner N
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133745
Hypoxia-activated Smad3-specific dephosphorylation by PP2A.
Heikkinen PT, Nummela M, Leivonen SK, Westermarck J, Hill CS, Kähäri VM, Jaakkola PM
J Biol Chem. 2010
PubMed ID: 19951945
Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.
Wang X, Chorley BN, Pittman GS, Kleeberger SR, Brothers J, Liu G, Spira A, Bell DA
PLoS One. 2010
PubMed ID: 20689807
Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
An integrated workflow for charting the human interaction proteome: insights into the PP2A system.
Glatter T, Wepf A, Aebersold R, Gstaiger M
Mol Syst Biol. 2009
PubMed ID: 19156129
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.
Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC
Mol Cell Proteomics. 2009
PubMed ID: 18782753
PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.
Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC
J Biol Chem. 2008
PubMed ID: 18715871
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
Liu WB, Li Y, Zhang L, Chen HG, Sun S, Liu JP, Liu Y, Li DW
Mol Vis. 2008
PubMed ID: 18432318
Alterations of tumour suppressor gene PPP2R1B in hepatocellular carcinoma.
Chou HC, Chen CH, Lee HS, Lee CZ, Huang GT, Yang PM, Lee PH, Sheu JC
Cancer Lett. 2007
PubMed ID: 17324501
Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer.
Yeh LS, Hsieh YY, Chang JG, Chang WW, Chang CC, Tsai FJ
Int J Gynecol Cancer. 2007
PubMed ID: 17343570
The tumor suppressor PP2A Abeta regulates the RalA GTPase.
Sablina AA, Chen W, Arroyo JD, Corral L, Hector M, Bulmer SE, DeCaprio JA, Hahn WC
Cell. 2007
PubMed ID: 17540176
Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B.
Kalla C, Scheuermann MO, Kube I, Schlotter M, Mertens D, Döhner H, Stilgenbauer S, Lichter P
Eur J Cancer. 2007
PubMed ID: 17449237
Shugoshin collaborates with protein phosphatase 2A to protect cohesin.
Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y
Nature. 2006
PubMed ID: 16541025
Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.
Riedel CG, Katis VL, Katou Y, Mori S, Itoh T, Helmhart W, Gálová M, Petronczki M, Gregan J, Cetin B, Mudrak I, Ogris E, Mechtler K, Pelletier L, Buchholz F, Shirahige K, Nasmyth K
Nature. 2006
PubMed ID: 16541024
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
Nature. 2006
PubMed ID: 16554811
The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function.
Esplin ED, Ramos P, Martinez B, Tomlinson GE, Mumby MC, Evans GA
Genes Chromosomes Cancer. 2006
PubMed ID: 16276521
14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.
Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR
J Cell Sci. 2005
PubMed ID: 16306228
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Interaction of the protein phosphatase 2A with the regulatory domain of the cystic fibrosis transmembrane conductance regulator channel.
Vastiau A, Cao L, Jaspers M, Owsianik G, Janssens V, Cuppens H, Goris J, Nilius B, Cassiman JJ
FEBS Lett. 2005
PubMed ID: 15936019
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
PPP2R1B gene alterations inhibit interaction of PP2A-Abeta and PP2A-C proteins in colorectal cancers.
Tamaki M, Goi T, Hirono Y, Katayama K, Yamaguchi A
Oncol Rep. 2004
PubMed ID: 14767517
Type-2A protein phosphatase activity is required to maintain death receptor responsiveness.
Härmälä-Braskén AS, Mikhailov A, Söderström TS, Meinander A, Holmström TH, Damuni Z, Eriksson JE
Oncogene. 2003
PubMed ID: 14576831
Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A.
Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA
J Biol Chem. 2003
PubMed ID: 12912990
Interaction between protein phosphatase 2A and members of the importin beta superfamily.
Lubert EJ, Sarge KD
Biochem Biophys Res Commun. 2003
PubMed ID: 12670497
Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution.
Zhou J, Pham HT, Ruediger R, Walter G
Biochem J. 2003
PubMed ID: 12370081
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.
Hrimech M, Yao XJ, Branton PE, Cohen EA
EMBO J. 2002
PubMed ID: 12110603
Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits.
Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT
J Biol Chem. 2002
PubMed ID: 11929880
Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas.
Hemmer S, Wasenius VM, Haglund C, Zhu Y, Knuutila S, Franssila K, Joensuu H
Cancer Genet Cytogenet. 2002
PubMed ID: 11996789
Protein phosphatase 2A interacts with and directly dephosphorylates RelA.
Yang J, Fan GH, Wadzinski BE, Sakurai H, Richmond A
J Biol Chem. 2001
PubMed ID: 11591705
HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.
Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y
Virology. 2001
PubMed ID: 11531413
Involvement of protein phosphatase 2A in the interleukin-3-stimulated Jak2-Stat5 signaling pathway.
Yokoyama N, Reich NC, Miller WT
J Interferon Cytokine Res. 2001
PubMed ID: 11440634
Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene.
Ruediger R, Pham HT, Walter G
Oncogene. 2001
PubMed ID: 11313937
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region.
Baysal BE, Willett-Brozick JE, Taschner PE, Dauwerse JG, Devilee P, Devlin B
Eur J Hum Genet. 2001
PubMed ID: 11313745
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Type 2A protein phosphatase, the complex regulator of numerous signaling pathways.
Zolnierowicz S
Biochem Pharmacol. 2000
PubMed ID: 11007961
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.
Hrimech M, Yao XJ, Branton PE, Cohen EA
EMBO J. 2000
PubMed ID: 10921877
Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers.
Takagi Y, Futamura M, Yamaguchi K, Aoki S, Takahashi T, Saji S
Gut. 2000
PubMed ID: 10896920
Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation.
Abraham D, Podar K, Pacher M, Kubicek M, Welzel N, Hemmings BA, Dilworth SM, Mischak H, Kolch W, Baccarini M
J Biol Chem. 2000
PubMed ID: 10801873
Absence of PPP2R1B gene alterations in primary ovarian cancers.
Campbell IG, Manolitsas T
Oncogene. 1999
PubMed ID: 10597236
Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus.
Takahashi M, Shibata H, Shimakawa M, Miyamoto M, Mukai H, Ono Y
J Biol Chem. 1999
PubMed ID: 10358086
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Alterations of the PPP2R1B gene in human lung and colon cancer.
Wang SS, Esplin ED, Li JL, Huang L, Gazdar A, Minna J, Evans GA
Science. 1998
PubMed ID: 9765152
Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23.
Baysal BE, Farr JE, Goss JR, Devlin B, Richard CW
Gene. 1998
PubMed ID: 9795170
Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.
Ruediger R, Brewis N, Ohst K, Walter G
Virology. 1997
PubMed ID: 9400615
HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A.
Adler HT, Nallaseth FS, Walter G, Tkachuk DC
J Biol Chem. 1997
PubMed ID: 9353299
Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.
Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R
FEBS Lett. 1997
PubMed ID: 9013886
The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.
McCright B, Rivers AM, Audlin S, Virshup DM
J Biol Chem. 1996
PubMed ID: 8703017
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits.
Kamibayashi C, Lickteig RL, Estes R, Walter G, Mumby MC
J Biol Chem. 1992
PubMed ID: 1328247
alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure.
Hemmings BA, Adams-Pearson C, Maurer F, Müller P, Goris J, Merlevede W, Hofsteenge J, Stone SR
Biochemistry. 1990
PubMed ID: 2159327

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	5519	73699	315648
EnsEMBL Gene(s)	ENSG00000137713	ENSMUSG00000032058	ENSRNOG00000010922
Unigene	Hs.584790	Mm.7726	Rn.163017
Homologene	PPP2R1B	Ppp2r1b	Ppp2r1b
OMIM	603113	N/A	N/A
GeneCards	PPP2R1B	N/A	N/A
Beta Cell Genomics	DT.100647153 DT.100799991 DT.453780	DT.101219421 DT.101268394 DT.103569502 DT.99857596	N/A
Reactome	P30154	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	5519	73699	315648

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
PPP2R1B	CDK4	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1B	STK25	IntAct, BioGRID	empirical	18782753
PPP2R1B	CFTR	HPRD	empirical	15936019
PPP2R1B	FGFR1OP	HPRD, IntAct	empirical	17540176
PPP2R1B	PDCD10	IntAct, BioGRID	empirical	18782753
PPP2R1B	PARK7	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1B	SGOL2	HPRD, IntAct, BioGRID	empirical	16541025 20360068
PPP2R1B	SGOL1	HPRD	empirical	16541024 16541025
PPP2R1B	DAPK1	IntAct	empirical	21172653
PPP2R1B	DAPK3	IntAct	empirical	21172653
PPP2R1B	EEF2	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1B	UNC5B	IntAct	empirical	21172653
PPP2R1B	RAB18	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1B	SIK2	IntAct	empirical	16306228
PPP2R1B	MOB4	IntAct, BioGRID	empirical	18782753
PPP2R1B	INTS1	BioGRID	empirical	20133760
PPP2R1B	INTS6	BioGRID	empirical	20133760
PPP2R1B	PPP2R3B	BioGRID	empirical	12370081
PPP2R1B	STRN4	IntAct	empirical	18782753
PPP2R1B	STRN3	HPRD, IntAct, BioGRID	empirical	17540176 18782753
PPP2R1B	HDAC1	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1B	ANXA5	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1B	HSPD1	HPRD, IntAct	empirical	17540176
PPP2R1B	JAK2	HPRD, BioGRID	empirical	11440634
PPP2R1B	MCM3	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1B	MAP3K3	MINT, IntAct	empirical	14743216
PPP2R1B	NFKB2	MINT	empirical	14743216
PPP2R1B	PRDX1	HPRD, IntAct	empirical	17540176
PPP2R1B	MST4	IntAct	empirical	18782753
PPP2R1B	USP53	IntAct, BioGRID	empirical	19615732
PPP2R1B	ZRANB1	IntAct, BioGRID	empirical	19615732
PPP2R1B	MARCH1	BioGRID	empirical	17540176
PPP2R1B	PPP2CA	HPRD, IntAct, BioGRID	empirical	17540176 18715871 19156129 18782753 12370081
PPP2R1B	PPP2CB	IntAct, BioGRID, Sanger Interaction Map	empirical	19156129 12370081 15345047
PPP2R1B	PPP2R1A	IntAct, BioGRID	empirical	18782753 17540176
PPP2R1B	PPP2R2A	HPRD, IntAct, BioGRID	empirical	1328247 17540176 12370081 19156129
PPP2R1B	PPP2R2B	IntAct, BioGRID	empirical	19156129
PPP2R1B	PPP2R2C	IntAct, BioGRID	empirical	18782753 19156129
PPP2R1B	PPP2R5A	IntAct, BioGRID	empirical	17540176 18782753 12370081 8703017
PPP2R1B	PPP2R5B	BioGRID	empirical	8703017
PPP2R1B	PPP2R5C	HPRD, MINT, IntAct, BioGRID	empirical	11929880 16456541 17540176 8703017
PPP2R1B	PPP2R5D	HPRD, IntAct, BioGRID	empirical	16541025 17540176 8703017
PPP2R1B	PPP2R5E	HPRD, IntAct, BioGRID	empirical	17540176 8703017
PPP2R1B	PRKAA1	BioGRID	empirical	16306228
PPP2R1B	PPP2R2D	IntAct, BioGRID	empirical	19156129
PPP2R1B	CTTNBP2NL	IntAct, BioGRID	empirical	18782753
PPP2R1B	RALA	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1B	RELA	HPRD	empirical	11591705
PPP2R1B	SET	HPRD, MIPS	empirical	9353299
PPP2R1B	INTS3	BioGRID	empirical	20133760
PPP2R1B	STAT3	BioGRID	empirical	17540176
PPP2R1B	STRN	HPRD, IntAct, BioGRID	empirical	17540176 18782753
PPP2R1B	BSG	HPRD	empirical	17540176
PPP2R1B	PRDX2	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1B	TNFAIP3	BioGRID	empirical	19615732
PPP2R1B	UBC	BioGRID	empirical	21987572 21963094 21139048 21890473 21906983
PPP2R1B	RAB7A	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1B	TNIP3	IntAct	empirical	19615732
PPP2R1B	DOCK5	IntAct	empirical	19156129
PPP2R1B	SIKE1	IntAct	empirical	18782753
PPP2R1B	TRAF3IP3	IntAct	empirical	18782753
PPP2R1B	INTS5	BioGRID	empirical	20133760
PPP2R1B	CTTNBP2	IntAct	empirical	18782753
PPP2R1B	STK24	IntAct	empirical	18782753
PPP2R1B	FAM40A	IntAct	empirical	18782753
PPP2R1B	RAB11A	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1B	ULK2	IntAct	empirical	20562859
PPP2R1B	CDK1	HPRD, IntAct, BioGRID	empirical	17540176