PPP2R1A

Summary Top Help

Gene Description:

protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform; protein phosphatase 2, regulatory subunit A, alpha

Synonyms:

PR65A, PP2A-Aalpha, PP2AAALPHA, 6330556D22Rik, PPP2R1A, Ppp2r1a, PR65, PP2A

Orthologs:

Human PPP2R1A (protein-coding), Mouse Ppp2r1a (protein-coding), Rat Ppp2r1a (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd23	Mouse	chr17:3924615..26319104	22.39	376

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr19:52693055..52730687 (37.63 kb) View in Genome Browser

(Mouse) NCBIM37 - chr17:21082275..21102880 (20.61 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:58442220..58461462 (19.24 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PPP2R1A:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PPP2R1A:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 8

Biocarta: None available

Reactome: 37

NCI-Nature Pathway Interaction Database: 5

Gene Ontology: 41

Publications from PubMed Top Help

Publications: 146

Identification and functional analyses of polymorphism haplotypes of protein phosphatase 2A-Aα gene promoter.
Lin YC, Chen HF, Lin LN, Luo J, Li W, Zhang SJ, Li XJ, Hu YM, Chen YX, Chen W, Lin ZN
Mutat Res. 2011
PubMed ID: 21889517
The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification.
Brownlee CW, Klebba JE, Buster DW, Rogers GC
J Cell Biol. 2011
PubMed ID: 21987638
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice.
Ruediger R, Ruiz J, Walter G
Mol Cell Biol. 2011
PubMed ID: 21791616
Protein phosphatase 2A catalytic subunit α (PP2Acα) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway.
Chen W, Gu P, Jiang X, Ruan HB, Li C, Gao X
Am J Pathol. 2011
PubMed ID: 21514445
Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720.
Chang HY, Jennings PC, Stewart J, Verrills NM, Jones KT
J Biol Chem. 2011
PubMed ID: 21383018
Somatic mutations of PPP2R1A in ovarian and uterine carcinomas.
Shih IeM, Panuganti PK, Kuo KT, Mao TL, Kuhn E, Jones S, Velculescu VE, Kurman RJ, Wang TL
Am J Pathol. 2011
PubMed ID: 21435433
Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas.
McConechy MK, Anglesio MS, Kalloger SE, Yang W, Senz J, Chow C, Heravi-Moussavi A, Morin GB, Mes-Masson AM, Australian Ovarian Cancer Study Group, Carey MS, McAlpine JN, Kwon JS, Prentice LM, Boyd N, Shah SP, Gilks CB, Huntsman DG
J Pathol. 2011
PubMed ID: 21381030
Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation.
Eitelhuber AC, Warth S, Schimmack G, Düwel M, Hadian K, Demski K, Beisker W, Shinohara H, Kurosaki T, Heissmeyer V, Krappmann D
EMBO J. 2011
PubMed ID: 21157432
Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
Greco TM, Yu F, Guise AJ, Cristea IM
Mol Cell Proteomics. 2011
PubMed ID: 21081666
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma.
Jones S, Wang TL, Shih IeM, Mao TL, Nakayama K, Roden R, Glas R, Slamon D, Diaz LA, Vogelstein B, Kinzler KW, Velculescu VE, Papadopoulos N
Science. 2010
PubMed ID: 20826764
Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.
Schmitz MH, Held M, Janssens V, Hutchins JR, Hudecz O, Ivanova E, Goris J, Trinkle-Mulcahy L, Lamond AI, Poser I, Hyman AA, Mechtler K, Peters JM, Gerlich DW
Nat Cell Biol. 2010
PubMed ID: 20711181
Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
Xu G, Paige JS, Jaffrey SR
Nat Biotechnol. 2010
PubMed ID: 20639865
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.
Pardo M, Lang B, Yu L, Prosser H, Bradley A, Babu MM, Choudhary J
Cell Stem Cell. 2010
PubMed ID: 20362542
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
Streamlined analysis schema for high-throughput identification of endogenous protein complexes.
Malovannaya A, Li Y, Bulynko Y, Jung SY, Wang Y, Lanz RB, O'Malley BW, Qin J
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133760
Hypoxia-activated Smad3-specific dephosphorylation by PP2A.
Heikkinen PT, Nummela M, Leivonen SK, Westermarck J, Hill CS, Kähäri VM, Jaakkola PM
J Biol Chem. 2010
PubMed ID: 19951945
Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk.
Dupont WD, Breyer JP, Bradley KM, Schuyler PA, Plummer WD, Sanders ME, Page DL, Smith JR
Cancer. 2010
PubMed ID: 19890961
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway.
Kozhemyakina E, Cohen T, Yao TP, Lassar AB
Mol Cell Biol. 2009
PubMed ID: 19704004
Alpha4 is an essential regulator of PP2A phosphatase activity.
Kong M, Ditsworth D, Lindsten T, Thompson CB
Mol Cell. 2009
PubMed ID: 19818709
A nonhomologous end-joining pathway is required for protein phosphatase 2A promotion of DNA double-strand break repair.
Wang Q, Gao F, Wang T, Flagg T, Deng X
Neoplasia. 2009
PubMed ID: 19794960
Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development.
O'Shaughnessy RF, Welti JC, Sully K, Byrne C
Development. 2009
PubMed ID: 19762425
Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.
Martinez G, Wijesinghe M, Turner K, Abud HE, Taketo MM, Noda T, Robinson ML, de Iongh RU
Invest Ophthalmol Vis Sci. 2009
PubMed ID: 19515997
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms.
Lu J, Kovach JS, Johnson F, Chiang J, Hodes R, Lonser R, Zhuang Z
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19564615
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
The 48-kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation.
Jin Z, Shi J, Saraf A, Mei W, Zhu GZ, Strack S, Yang J
J Biol Chem. 2009
PubMed ID: 19129191
Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding.
Deng X, Gao F, May WS
Blood. 2009
PubMed ID: 18845789
Transcriptional regulation of PP2A-A alpha is mediated by multiple factors including AP-2alpha, CREB, ETS-1, and SP-1.
Chen HG, Han WJ, Deng M, Qin J, Yuan D, Liu JP, Xiao L, Gong L, Liang S, Zhang J, Liu Y, Li DW
PLoS One. 2009
PubMed ID: 19750005
An integrated workflow for charting the human interaction proteome: insights into the PP2A system.
Glatter T, Wepf A, Aebersold R, Gstaiger M
Mol Syst Biol. 2009
PubMed ID: 19156129
Peroxynitrite-dependent activation of protein phosphatase type 2A mediates microvascular endothelial barrier dysfunction.
Wu F, Wilson JX
Cardiovasc Res. 2009
PubMed ID: 18791203
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.
Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC
Mol Cell Proteomics. 2009
PubMed ID: 18782753
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.
Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC
J Biol Chem. 2008
PubMed ID: 18715871
S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade.
Narayanan U, Nalavadi V, Nakamoto M, Thomas G, Ceman S, Bassell GJ, Warren ST
J Biol Chem. 2008
PubMed ID: 18474609
Adenosine A1 and A2A receptor regulation of protein phosphatase 2A in the murine heart.
Tikh EI, Fenton RA, Chen JF, Schwarzschild MA, Dobson JG
J Cell Physiol. 2008
PubMed ID: 18181173
Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y
Cell. 2008
PubMed ID: 18394995
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
PP2A regulates the pro-apoptotic activity of FOXO1.
Yan L, Lavin VA, Moser LR, Cui Q, Kanies C, Yang E
J Biol Chem. 2008
PubMed ID: 18211894
Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A.
Zwaenepoel K, Louis JV, Goris J, Janssens V
BMC Genomics. 2008
PubMed ID: 18715506
Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.
Ortega-Gutiérrez S, Leung D, Ficarro S, Peters EC, Cravatt BF
PLoS ONE. 2008
PubMed ID: 18596935
Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
Liu WB, Li Y, Zhang L, Chen HG, Sun S, Liu JP, Liu Y, Li DW
Mol Vis. 2008
PubMed ID: 18432318
Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner.
Andrabi S, Gjoerup OV, Kean JA, Roberts TM, Schaffhausen B
Proc Natl Acad Sci U S A. 2007
PubMed ID: 18006659
C3G mediated suppression of malignant transformation involves activation of PP2A phosphatases at the subcortical actin cytoskeleton.
Martín-Encabo S, Santos E, Guerrero C
Exp Cell Res. 2007
PubMed ID: 17825818
GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis.
Lin CF, Chen CL, Chiang CW, Jan MS, Huang WC, Lin YS
J Cell Sci. 2007
PubMed ID: 17666435
Structural basis of PP2A inhibition by small t antigen.
Cho US, Morrone S, Sablina AA, Arroyo JD, Hahn WC, Xu W
PLoS Biol. 2007
PubMed ID: 17608567
Inhibition of protein phosphatases induces transport deficits and axonopathy.
Yang Y, Yang XF, Wang YP, Tian Q, Wang XC, Li HL, Wang Q, Wang JZ
J Neurochem. 2007
PubMed ID: 17472709
CIP2A inhibits PP2A in human malignancies.
Junttila MR, Puustinen P, Niemelä M, Ahola R, Arnold H, Böttzauw T, Ala-aho R, Nielsen C, Ivaska J, Taya Y, Lu SL, Lin S, Chan EK, Wang XJ, Grènman R, Kast J, Kallunki T, Sears R, Kähäri VM, Westermarck J
Cell. 2007
PubMed ID: 17632056
The tumor suppressor PP2A Abeta regulates the RalA GTPase.
Sablina AA, Chen W, Arroyo JD, Corral L, Hector M, Bulmer SE, DeCaprio JA, Hahn WC
Cell. 2007
PubMed ID: 17540176
Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A (PP2A): Is Galpha12 a novel regulatory subunit of PP2A?
Zhu D, Tate RI, Ruediger R, Meigs TE, Denker BM
Mol Pharmacol. 2007
PubMed ID: 17303700
Leishmania donovani-induced ceramide as the key mediator of Akt dephosphorylation in murine macrophages: role of protein kinase Czeta and phosphatase.
Dey R, Majumder N, Bhattacharjee S, Majumdar SB, Banerjee R, Ganguly S, Das P, Majumdar S
Infect Immun. 2007
PubMed ID: 17220321
Heptad repeats regulate protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator and are targeted by human T-lymphotropic virus type 1 tax.
Hong S, Wang LC, Gao X, Kuo YL, Liu B, Merling R, Kung HJ, Shih HM, Giam CZ
J Biol Chem. 2007
PubMed ID: 17314097
Mechanisms of the HRSL3 tumor suppressor function in ovarian carcinoma cells.
Nazarenko I, Schäfer R, Sers C
J Cell Sci. 2007
PubMed ID: 17374643
Phosphatase type 2A-dependent and -independent pathways for ATR phosphorylation of Chk1.
Li G, Elder RT, Qin K, Park HU, Liang D, Zhao RY
J Biol Chem. 2007
PubMed ID: 17210576
Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNA.
Sun L, Stoecklin G, Van Way S, Hinkovska-Galcheva V, Guo RF, Anderson P, Shanley TP
J Biol Chem. 2007
PubMed ID: 17170118
Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.
Cannavo E, Gerrits B, Marra G, Schlapbach R, Jiricny J
J Biol Chem. 2007
PubMed ID: 17148452
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.
Li HH, Cai X, Shouse GP, Piluso LG, Liu X
EMBO J. 2007
PubMed ID: 17245430
Identification of the PP2A-interacting region of heat shock transcription factor 2.
Xing H, Hong Y, Sarge KD
Cell Stress Chaperones. 2007
PubMed ID: 17688198
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1.
Zuluaga S, Alvarez-Barrientos A, Gutiérrez-Uzquiza A, Benito M, Nebreda AR, Porras A
Cell Signal. 2007
PubMed ID: 16844343
Structure of the protein phosphatase 2A holoenzyme.
Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD, Shi Y
Cell. 2006
PubMed ID: 17174897
RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signaling.
Li S, Wang L, Berman MA, Zhang Y, Dorf ME
Mol Cell. 2006
PubMed ID: 17188031
Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins.
Xing Y, Xu Y, Chen Y, Jeffrey PD, Chao Y, Lin Z, Li Z, Strack S, Stock JB, Shi Y
Cell. 2006
PubMed ID: 17055435
Induction of E-cadherin endocytosis by loss of protein phosphatase 2A expression in human breast cancers.
Suzuki K, Takahashi K
Biochem Biophys Res Commun. 2006
PubMed ID: 16930554
PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum.
Lin SS, Bassik MC, Suh H, Nishino M, Arroyo JD, Hahn WC, Korsmeyer SJ, Roberts TM
J Biol Chem. 2006
PubMed ID: 16717086
Shugoshin collaborates with protein phosphatase 2A to protect cohesin.
Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y
Nature. 2006
PubMed ID: 16541025
Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.
Riedel CG, Katis VL, Katou Y, Mori S, Itoh T, Helmhart W, Gálová M, Petronczki M, Gregan J, Cetin B, Mudrak I, Ogris E, Mechtler K, Pelletier L, Buchholz F, Shirahige K, Nasmyth K
Nature. 2006
PubMed ID: 16541024
Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice.
Schild A, Isenmann S, Tanimoto N, Tonagel F, Seeliger MW, Ittner LM, Kretz A, Ogris E, Götz J
Mech Dev. 2006
PubMed ID: 16679006
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.
Tang Z, Shu H, Qi W, Mahmood NA, Mumby MC, Yu H
Dev Cell. 2006
PubMed ID: 16580887
The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.
Petretti C, Savoian M, Montembault E, Glover DM, Prigent C, Giet R
EMBO Rep. 2006
PubMed ID: 16462731
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A.
Kray AE, Carter RS, Pennington KN, Gomez RJ, Sanders LE, Llanes JM, Khan WN, Ballard DW, Wadzinski BE
J Biol Chem. 2005
PubMed ID: 16126728
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Protein phosphatase 2A regulates apoptosis in intestinal epithelial cells.
Ray RM, Bhattacharya S, Johnson LR
J Biol Chem. 2005
PubMed ID: 15994315
Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins.
Sung U, Jennings JL, Link AJ, Blakely RD
Biochem Biophys Res Commun. 2005
PubMed ID: 15963952
Pim family kinases enhance tumor growth of prostate cancer cells.
Chen WW, Chan DC, Donald C, Lilly MB, Kraft AS
Mol Cancer Res. 2005
PubMed ID: 16123140
Heat treatment decreases melanin synthesis via protein phosphatase 2A inactivation.
Kim DS, Park SH, Kwon SB, Youn SW, Park ES, Park KC
Cell Signal. 2005
PubMed ID: 15894174
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.
Zhu D, Kosik KS, Meigs TE, Yanamadala V, Denker BM
J Biol Chem. 2004
PubMed ID: 15525651
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes.
Ugi S, Imamura T, Maegawa H, Egawa K, Yoshizaki T, Shi K, Obata T, Ebina Y, Kashiwagi A, Olefsky JM
Mol Cell Biol. 2004
PubMed ID: 15367694
Overexpression of the catalytic subunit of protein phosphatase 2A impairs cardiac function.
Gergs U, Boknik P, Buchwalow I, Fabritz L, Matus M, Justus I, Hanske G, Schmitz W, Neumann J
J Biol Chem. 2004
PubMed ID: 15247211
Functional proteomics mapping of a human signaling pathway.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM
Genome Res. 2004
PubMed ID: 15231748
The DNA sequence and biology of human chromosome 19.
Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM
Nature. 2004
PubMed ID: 15057824
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
A truncated isoform of the PP2A B56gamma regulatory subunit reduces irradiation-induced Mdm2 phosphorylation and could contribute to metastatic melanoma cell radioresistance.
Koma YI, Ito A, Watabe K, Kimura SH, Kitamura Y
Histol Histopathol. 2004
PubMed ID: 15024700
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G
J Biol Chem. 2004
PubMed ID: 14676191
Tumor-derived prostaglandin E2 and transforming growth factor-beta stimulate endothelial cell motility through inhibition of protein phosphatase-2A and involvement of PTEN and phosphatidylinositide 3-kinase.
Young MR
Angiogenesis. 2004
PubMed ID: 15516833
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Reduced expression of the regulatory A subunit of serine/threonine protein phosphatase 2A in human breast cancer MCF-7 cells.
Suzuki K, Takahashi K
Int J Oncol. 2003
PubMed ID: 14532964
A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo.
Fellner T, Lackner DH, Hombauer H, Piribauer P, Mudrak I, Zaragoza K, Juno C, Ogris E
Genes Dev. 2003
PubMed ID: 12952889
Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis.
Chiang CW, Kanies C, Kim KW, Fang WB, Parkhurst C, Xie M, Henry T, Yang E
Mol Cell Biol. 2003
PubMed ID: 12944463
Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital.
Yoshinari K, Kobayashi K, Moore R, Kawamoto T, Negishi M
FEBS Lett. 2003
PubMed ID: 12885400
Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.
Casenghi M, Meraldi P, Weinhart U, Duncan PI, Körner R, Nigg EA
Dev Cell. 2003
PubMed ID: 12852856
Interaction between protein phosphatase 2A and members of the importin beta superfamily.
Lubert EJ, Sarge KD
Biochem Biophys Res Commun. 2003
PubMed ID: 12670497
Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution.
Zhou J, Pham HT, Ruediger R, Walter G
Biochem J. 2003
PubMed ID: 12370081
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.
Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y
Mol Biol Cell. 2002
PubMed ID: 12221128
Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.
Hrimech M, Yao XJ, Branton PE, Cohen EA
EMBO J. 2002
PubMed ID: 12110603
Transgenic expression of protein phosphatase 2A regulatory subunit B56gamma disrupts distal lung differentiation.
Everett AD, Kamibayashi C, Brautigan DL
Am J Physiol Lung Cell Mol Physiol. 2002
PubMed ID: 12003782
Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A.
Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, Collins M, Carreno BM, Madrenas J, Kuchroo VK
J Immunol. 2002
PubMed ID: 11994459
Protein phosphatase-2A modulates the serine and tyrosine phosphorylation of paxillin in Lewis lung carcinoma tumor variants.
Jackson JL, Young MR
Clin Exp Metastasis. 2002
PubMed ID: 12198769
Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A.
Li X, Virshup DM
Eur J Biochem. 2002
PubMed ID: 11856313
Overexpression of tightly regulated proteins: protein phosphatase 2A overexpression in NIH 3T3 cells.
Ram PT
Methods Enzymol. 2002
PubMed ID: 11665638
Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5.
Lubert EJ, Hong Y, Sarge KD
J Biol Chem. 2001
PubMed ID: 11504734
HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.
Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y
Virology. 2001
PubMed ID: 11531413
Absence of PPP2R1A mutations in Wilms tumor.
Ruteshouser EC, Ashworth LK, Huff V
Oncogene. 2001
PubMed ID: 11360189
The effects of aging on gene expression in the hypothalamus and cortex of mice.
Jiang CH, Tsien JZ, Schultz PG, Hu Y
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11172053
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion.
Mayor T, Stierhof YD, Tanaka K, Fry AM, Nigg EA
J Cell Biol. 2000
PubMed ID: 11076968
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Type 2A protein phosphatase, the complex regulator of numerous signaling pathways.
Zolnierowicz S
Biochem Pharmacol. 2000
PubMed ID: 11007961
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.
Hrimech M, Yao XJ, Branton PE, Cohen EA
EMBO J. 2000
PubMed ID: 10921877
Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.
Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG
Nat Neurosci. 2000
PubMed ID: 10862698
PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells.
Yan Z, Fedorov SA, Mumby MC, Williams RS
Mol Cell Biol. 2000
PubMed ID: 10629059
Regulation of protein phosphatase 2A activity by heat shock transcription factor 2.
Hong Y, Sarge KD
J Biol Chem. 1999
PubMed ID: 10224043
Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases.
Nanahoshi M, Tsujishita Y, Tokunaga C, Inui S, Sakaguchi N, Hara K, Yonezawa K
FEBS Lett. 1999
PubMed ID: 10100624
Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.
Hsu W, Zeng L, Costantini F
J Biol Chem. 1999
PubMed ID: 9920888
The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.
Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D
Cell. 1999
PubMed ID: 9989501
Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens.
Ruediger R, Fields K, Walter G
J Virol. 1999
PubMed ID: 9847399
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.
Ruediger R, Brewis N, Ohst K, Walter G
Virology. 1997
PubMed ID: 9400615
Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.
Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R
FEBS Lett. 1997
PubMed ID: 9013886
The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.
Zolnierowicz S, Van Hoof C, Andjelković N, Cron P, Stevens I, Merlevede W, Goris J, Hemmings BA
Biochem J. 1996
PubMed ID: 8694763
Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle.
Tehrani MA, Mumby MC, Kamibayashi C
J Biol Chem. 1996
PubMed ID: 8617797
Identification of a new family of protein phosphatase 2A regulatory subunits.
McCright B, Virshup DM
J Biol Chem. 1995
PubMed ID: 7592815
Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.
Golsteyn RM, Mundt KE, Fry AM, Nigg EA
J Cell Biol. 1995
PubMed ID: 7790358
Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens.
Ruediger R, Hentz M, Fait J, Mumby M, Walter G
J Virol. 1994
PubMed ID: 8254721
Expression of PP2A B regulatory subunit beta isotype in rat testis.
Hatano Y, Shima H, Haneji T, Miura AB, Sugimura T, Nagao M
FEBS Lett. 1993
PubMed ID: 8389301
Increase in potential activities of protein phosphatases PP1 and PP2A in lymphoid tissues of autoimmune MRL/MpJ-lpr/lpr mice.
Matsuzawa S, Tamura T, Mizuno Y, Kobayashi S, Okuyama H, Tsukitani Y, Uemura D, Kikuchi K
J Biochem. 1992
PubMed ID: 1319990
alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure.
Hemmings BA, Adams-Pearson C, Maurer F, Müller P, Goris J, Merlevede W, Hofsteenge J, Stone SR
Biochemistry. 1990
PubMed ID: 2159327
Association of protein phosphatase 2A with polyoma virus medium tumor antigen.
Walter G, Ruediger R, Slaughter C, Mumby M
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2157202
Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein.
Walter G, Ferre F, Espiritu O, Carbone-Wiley A
Proc Natl Acad Sci U S A. 1989
PubMed ID: 2554323

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	5518	51792	117281
EnsEMBL Gene(s)	ENSG00000105568	ENSMUSG00000007564	ENSRNOG00000011282
Unigene	Hs.467192	Mm.294138	Rn.4108
Homologene	PPP2R1A	Ppp2r1a	Ppp2r1a
OMIM	605983	N/A	N/A
GeneCards	PPP2R1A	N/A	N/A
Beta Cell Genomics	DT.100045135 DT.100867339 DT.100867342 DT.121501414 DT.451403 DT.91775325 DT.92029602 DT.95287869 DT.95331984	DT.55100301 DT.91397660 DT.94251305	N/A
Reactome	P30153	N/A	N/A
Plasma Peptide Atlas	ENSP00000324804	N/A	N/A
WikiGenes	5518	51792	117281

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
PPP2R1A	HDAC5	BioGRID	empirical	21081666
PPP2R1A	ACTR1A	Reactome	predicted	12852856
PPP2R1A	AKAP9	Reactome	predicted	12852856
PPP2R1A	RBM7	IntAct, BioGRID	empirical	19156129
PPP2R1A	CDK4	IntAct, BioGRID	empirical	17540176
PPP2R1A	STUB1	BioGRID	empirical	19818709
PPP2R1A	EIF1B	IntAct	empirical	17353931
PPP2R1A	TUBB4A	Reactome	predicted	12852856
PPP2R1A	TUBB4B	Reactome	predicted	12852856
PPP2R1A	ANAPC10	IntAct, BioGRID	empirical	17540176
PPP2R1A	ARIH2	HPRD, MINT, IntAct, BioGRID	empirical	16169070
PPP2R1A	TAB1	IntAct	empirical	21988832
PPP2R1A	STK25	IntAct, BioGRID	empirical	18782753
PPP2R1A	DCTN2	Reactome	predicted	12852856
PPP2R1A	CETN2	Reactome	predicted	12852856
PPP2R1A	PLK4	Reactome	predicted	12852856
PPP2R1A	CFTR	MINT, IntAct	empirical	15936019 17110338
PPP2R1A	SDCCAG8	Reactome	predicted	12852856
PPP2R1A	CNTRL	Reactome	predicted	12852856
PPP2R1A	FGFR1OP	BioGRID, Reactome	empirical	19156129 12852856
PPP2R1A	PLA2G16	HPRD, IntAct	empirical	17374643
PPP2R1A	CEP250	Reactome	predicted	12852856
PPP2R1A	PDCD10	IntAct, BioGRID	empirical	18782753
PPP2R1A	DCTN3	Reactome	predicted	12852856
PPP2R1A	PARK7	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1A	PHB2	IntAct	empirical	17353931
PPP2R1A	GABARAP	IntAct	empirical	20562859
PPP2R1A	GABARAPL2	IntAct	empirical	20562859
PPP2R1A	LRRK2	IntAct	empirical	21983832
PPP2R1A	NEDD1	Reactome	predicted	12852856
PPP2R1A	SOGA1	IntAct, BioGRID	empirical	20360068
PPP2R1A	CSNK1D	Reactome	predicted	12852856
PPP2R1A	CSNK1E	Reactome	predicted	12852856
PPP2R1A	CSNK2B	IntAct	empirical	16857963
PPP2R1A	SGOL2	HPRD, IntAct, BioGRID	empirical	16541025 20360068
PPP2R1A	SGOL1	HPRD, IntAct, BioGRID	empirical	16541024 16541025 19156129 20360068
PPP2R1A	DCTN1	Reactome	predicted	12852856
PPP2R1A	DLG4	IntAct	empirical	19455133
PPP2R1A	DYNC1H1	Reactome	predicted	12852856
PPP2R1A	DYNC1I2	Reactome	predicted	12852856
PPP2R1A	EEF2	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1A	EIF4A1	IntAct	empirical	19293187 15761952
PPP2R1A	AKT1	MINT	empirical	16044149
PPP2R1A	FECH	IntAct, BioGRID	empirical	20360068
PPP2R1A	CEP164	Reactome	predicted	12852856
PPP2R1A	MAPRE1	Reactome	predicted	12852856
PPP2R1A	RAB18	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1A	NINL	Reactome	predicted	12852856
PPP2R1A	AZI1	Reactome	predicted	12852856
PPP2R1A	CEP152	Reactome	predicted	12852856
PPP2R1A	TNIK	IntAct	empirical	17353931
PPP2R1A	ANKLE2	IntAct, BioGRID	empirical	19156129
PPP2R1A	RPGRIP1L	IntAct	empirical	21565611
PPP2R1A	CLASP1	Reactome	predicted	12852856
PPP2R1A	SKIV2L2	IntAct, BioGRID	empirical	19156129
PPP2R1A	GABARAPL1	IntAct	empirical	20562859
PPP2R1A	FTSJ1	IntAct	empirical	17353931
PPP2R1A	PRR14L	IntAct, BioGRID	empirical	19156129
PPP2R1A	MOB4	IntAct, BioGRID	empirical	19156129 18782753
PPP2R1A	FGFR1OP2	BioGRID	empirical	19156129
PPP2R1A	INTS1	BioGRID	empirical	20133760
PPP2R1A	INTS6	BioGRID	empirical	20133760
PPP2R1A	GNA12	HPRD	empirical	15525651
PPP2R1A	PPP2R3B	HPRD, IntAct, MIPS, BioGRID	empirical	10629059 18782753 12370081
PPP2R1A	GRIN1	HPRD, MINT, IntAct	empirical	10862698 16635246
PPP2R1A	GRIN2B	IntAct	empirical	10862698
PPP2R1A	GRIN2D	HPRD	empirical	10862698
PPP2R1A	STRN4	IntAct, BioGRID	empirical	19156129 18782753
PPP2R1A	STRN3	HPRD, IntAct, BioGRID	empirical	17540176 19156129 18782753
PPP2R1A	HDAC1	BioGRID	empirical	17540176
PPP2R1A	HSF2	HPRD	empirical	10224043
PPP2R1A	HSP90AA1	IntAct, Reactome	empirical	19875381 12852856
PPP2R1A	HSPD1	HPRD, IntAct	empirical	17540176
PPP2R1A	IKBKB	IntAct	empirical	15102471
PPP2R1A	IRS1	IntAct	empirical	15602769
PPP2R1A	EIF6	IntAct	empirical	17353931
PPP2R1A	LPP	BioGRID	empirical	19156129
PPP2R1A	SMAD2	HPRD, MINT	empirical	15231748
PPP2R1A	SMAD3	HPRD, MINT	empirical	15231748
PPP2R1A	ARRB2	IntAct	empirical	17620599
PPP2R1A	MCC	IntAct, BioGRID	empirical	17353931
PPP2R1A	MCM3	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1A	MAP3K3	MINT, IntAct	empirical	14743216
PPP2R1A	MID1	BioGRID	empirical	19818709
PPP2R1A	MLH1	BioGRID	empirical	17148452
PPP2R1A	NEK2	Reactome	predicted	12852856
PPP2R1A	NFATC2	IntAct	empirical	21983832
PPP2R1A	NFKB2	MINT	empirical	14743216
PPP2R1A	NME2	IntAct	empirical	17353931
PPP2R1A	ODF2	Reactome	predicted	12852856
PPP2R1A	PAFAH1B1	Reactome	predicted	12852856
PPP2R1A	PRDX1	HPRD, IntAct	empirical	17540176
PPP2R1A	PCM1	Reactome	predicted	12852856
PPP2R1A	PCNT	Reactome	predicted	12852856
PPP2R1A	PPME1	IntAct, BioGRID	empirical	19156129 19293187 15761952 18782753 20360068
PPP2R1A	MST4	IntAct, BioGRID	empirical	18782753
PPP2R1A	PLK1	Reactome	predicted	12852856
PPP2R1A	PMS1	BioGRID	empirical	17148452
PPP2R1A	POU5F1	IntAct, BioGRID	empirical	20362542
PPP2R1A	NDE1	Reactome	predicted	12852856
PPP2R1A	MARCH1	BioGRID	empirical	17540176
PPP2R1A	CEP192	Reactome	predicted	12852856
PPP2R1A	HAUS2	Reactome	predicted	12852856
PPP2R1A	PPP2CA	HPRD, IntAct, BioGRID, Reactome	empirical	8617797 17540176 18715871 17055435 19156129 19293187 15761952 18782753 20360068 16857963 12370081 9920888 19818709 12593796 11053437 12815057
PPP2R1A	PPP2CB	MINT, IntAct, BioGRID, Reactome	empirical	15936019 19156129 18782753 20360068 12370081 12593796 11053437 12815057
PPP2R1A	PPP2R1A	IntAct, BioGRID	empirical	20360068
PPP2R1A	PPP2R1B	IntAct, BioGRID	empirical	18782753 17540176
PPP2R1A	PPP2R2A	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	17540176 17245430 19156129 17632056 19293187 15761952 18782753 20360068 16857963 12370081
PPP2R1A	PPP2R2B	IntAct, BioGRID	empirical	19156129 21075311
PPP2R1A	PPP2R2C	IntAct, BioGRID	empirical	19156129 18782753
PPP2R1A	PPP2R3A	IntAct, MIPS	empirical	17055435 19293187 10629059
PPP2R1A	PPP2R4	BioGRID	empirical	19818709
PPP2R1A	PPP2R5A	HPRD, MINT, IntAct, BioGRID	empirical	11856313 7592815 17245430 18782753 20360068 12370081
PPP2R1A	PPP2R5B	IntAct	empirical	18782753
PPP2R1A	PPP2R5C	MINT, IntAct, BioGRID	empirical	17245430 8617797 19156129 18782753 20360068
PPP2R1A	PPP2R5D	IntAct, BioGRID	empirical	19156129 19293187 18782753 20360068
PPP2R1A	PPP2R5E	IntAct, BioGRID	empirical	19156129 18782753 20360068
PPP2R1A	PPP4C	HPRD, IntAct, BioGRID	empirical	18715871 17353931 19156129
PPP2R1A	PPP5C	HPRD	empirical	11504734
PPP2R1A	ZCCHC8	IntAct, BioGRID	empirical	19156129
PPP2R1A	PRKACA	IntAct, Reactome	empirical	16857963 12852856
PPP2R1A	IPO9	HPRD	empirical	12670497
PPP2R1A	CEP72	Reactome	predicted	12852856
PPP2R1A	CDK5RAP2	Reactome	predicted	12852856
PPP2R1A	PRKAR2B	Reactome	predicted	12852856
PPP2R1A	CENPJ	Reactome	predicted	12852856
PPP2R1A	PPP2R2D	IntAct, BioGRID	empirical	19156129 18782753 20360068
PPP2R1A	CTTNBP2NL	IntAct, BioGRID	empirical	18782753
PPP2R1A	MAPK3	MINT	empirical	19935650
PPP2R1A	MAPK6	BioGRID	empirical	21900206
PPP2R1A	SERTAD4	IntAct, BioGRID	empirical	19156129
PPP2R1A	PSMA1	IntAct	empirical	16857963
PPP2R1A	PSMA2	IntAct	empirical	16857963
PPP2R1A	PSMA3	IntAct	empirical	16857963
PPP2R1A	PSMA4	IntAct	empirical	16857963
PPP2R1A	PSMA5	IntAct	empirical	16857963
PPP2R1A	PSMA6	IntAct	empirical	16857963
PPP2R1A	PSMA7	IntAct	empirical	16857963
PPP2R1A	PSMB1	IntAct	empirical	16857963
PPP2R1A	PSMB2	IntAct	empirical	16857963
PPP2R1A	PSMB3	IntAct	empirical	16857963
PPP2R1A	PSMB4	IntAct	empirical	16857963
PPP2R1A	PSMB5	IntAct	empirical	16857963
PPP2R1A	PSMB6	IntAct	empirical	16857963
PPP2R1A	PSMB7	IntAct	empirical	16857963
PPP2R1A	PSMB8	IntAct	empirical	16857963
PPP2R1A	PSMB9	IntAct	empirical	16857963
PPP2R1A	PSMB10	IntAct	empirical	16857963
PPP2R1A	CTNNBIP1	IntAct, BioGRID	empirical	17353931
PPP2R1A	KIAA1524	IntAct	empirical	17632056 19293187
PPP2R1A	MARK4	IntAct, BioGRID	empirical	14676191
PPP2R1A	PTPRA	BioGRID	empirical	12952889
PPP2R1A	RAP1A	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1A	S100A9	IntAct	empirical	19156129
PPP2R1A	NXN	MINT	empirical	16764867
PPP2R1A	INTS3	BioGRID	empirical	20133760
PPP2R1A	SLC2A4	IntAct	empirical	16396496
PPP2R1A	SLC6A2	HPRD	empirical	15963952
PPP2R1A	STRN	HPRD, IntAct, BioGRID	empirical	17540176 19156129 18782753
PPP2R1A	PRDX2	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1A	TP53	MINT	empirical	17245430
PPP2R1A	TRAF6	IntAct	empirical	17353931
PPP2R1A	TUBA4A	Reactome	predicted	12852856
PPP2R1A	TUBG1	Reactome	predicted	12852856
PPP2R1A	UBC	BioGRID	empirical	16196087 19818709 20639865 18781797 21963094 21139048 21890473 21906983
PPP2R1A	YWHAB	IntAct	empirical	16635246
PPP2R1A	YWHAG	Reactome	predicted	12852856
PPP2R1A	YWHAZ	IntAct	empirical	19562802
PPP2R1A	ALMS1	Reactome	predicted	12852856
PPP2R1A	TUBA1A	Reactome	predicted	12852856
PPP2R1A	SLMAP	IntAct, BioGRID	empirical	19156129 18782753
PPP2R1A	RAB7A	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1A	PRR14	IntAct, BioGRID	empirical	19156129
PPP2R1A	AIMP2	BioGRID	empirical	21900206
PPP2R1A	CEP76	Reactome	predicted	12852856
PPP2R1A	DOCK5	IntAct	empirical	19156129
PPP2R1A	SIKE1	IntAct, BioGRID	empirical	18782753 19156129
PPP2R1A	CEP290	Reactome	predicted	12852856
PPP2R1A	CEP63	Reactome	predicted	12852856
PPP2R1A	CEP70	Reactome	predicted	12852856
PPP2R1A	TRAF3IP3	IntAct, BioGRID	empirical	18782753
PPP2R1A	INTS5	BioGRID	empirical	20133760
PPP2R1A	MAP1LC3B	IntAct	empirical	20562859
PPP2R1A	AXIN1	BioGRID	empirical	9920888
PPP2R1A	CTTNBP2	IntAct, BioGRID	empirical	18782753
PPP2R1A	BCAR3	IntAct	empirical	17353931
PPP2R1A	CEP78	Reactome	predicted	12852856
PPP2R1A	STK24	IntAct	empirical	17353931 18782753
PPP2R1A	OFD1	Reactome	predicted	12852856
PPP2R1A	PPFIA2	IntAct, BioGRID	empirical	18782753
PPP2R1A	PPFIA1	IntAct, BioGRID	empirical	19156129 18782753
PPP2R1A	FAM40A	IntAct, BioGRID	empirical	19156129 18782753
PPP2R1A	NKD1	IntAct	empirical	16567647 15687260
PPP2R1A	SSNA1	Reactome	predicted	12852856
PPP2R1A	DYNLL1	IntAct, BioGRID, Reactome	empirical	20360068 12852856
PPP2R1A	TRADD	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1A	RAB11A	HPRD, IntAct, BioGRID	empirical	17540176
PPP2R1A	CCNG1	MINT	empirical	17245430
PPP2R1A	ZFYVE9	HPRD, MINT	empirical	15231748
PPP2R1A	CEP41	Reactome	predicted	12852856
PPP2R1A	IKBKE	IntAct, BioGRID	empirical	17353931
PPP2R1A	CEP135	Reactome	predicted	12852856
PPP2R1A	CEP57	Reactome	predicted	12852856
PPP2R1A	CCP110	Reactome	predicted	12852856
PPP2R1A	KIAA0101	BioGRID	empirical	21628590
PPP2R1A	CKAP5	Reactome	predicted	12852856
PPP2R1A	SFI1	Reactome	predicted	12852856
PPP2R1A	CDK1	HPRD, IntAct, BioGRID, Reactome	empirical	17540176 12852856
PPP2R1A	CEP350	IntAct, BioGRID	empirical	20360068 19156129