PPP2CB
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(Human) GRCh37 - chr8:30631973..30671830 (39.86 kb) View in Genome Browser
(Mouse) NCBIM37 - chr8:34710093..34730276 (20.18 kb) View in Genome Browser
(Rat) RGSC3.4 - chr16:62330513..62351968 (21.45 kb) View in Genome Browser
HaemAtlas Expression Table for PPP2CB:
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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Expression Legend
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for PPP2CB:The PPP2CB interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| PPP2CB | HDAC5 | BioGRID | empirical | 21081666 |
| PPP2CB | ADARB1 | BioGRID | empirical | 19156129 |
| PPP2CB | TAB1 | IntAct | empirical | 21988832 |
| PPP2CB | PFDN6 | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | CCT7 | IntAct, BioGRID | empirical | 19156129 18782753 |
| PPP2CB | CCT4 | IntAct, BioGRID | empirical | 19156129 18782753 |
| PPP2CB | CCT2 | IntAct, BioGRID | empirical | 19156129 18782753 |
| PPP2CB | CCT8 | IntAct, BioGRID | empirical | 19156129 18782753 |
| PPP2CB | FGFR1OP | IntAct, BioGRID | empirical | 18782753 20360068 |
| PPP2CB | C22orf39 | BioGRID | empirical | 21900206 |
| PPP2CB | ZFP28 | BioGRID | empirical | 21900206 |
| PPP2CB | SGOL2 | IntAct, BioGRID | empirical | 20360068 |
| PPP2CB | SGOL1 | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | CCT5 | IntAct, BioGRID | empirical | 19156129 18782753 |
| PPP2CB | TAB2 | IntAct | empirical | 21988832 |
| PPP2CB | ANKLE2 | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | CBX5 | IntAct | empirical | 20562864 |
| PPP2CB | PRR14L | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | TCTEX1D2 | BioGRID | empirical | 21900206 |
| PPP2CB | MOB4 | IntAct, BioGRID | empirical | 19156129 18782753 |
| PPP2CB | TIPRL | IntAct, BioGRID, Sanger Interaction Map | empirical | 16085932 15345047 |
| PPP2CB | INTS1 | BioGRID | empirical | 20133760 |
| PPP2CB | GBE1 | Sanger Interaction Map | predicted | 15345047 |
| PPP2CB | INTS6 | BioGRID | empirical | 20133760 |
| PPP2CB | GH1 | IntAct | empirical | 17353931 |
| PPP2CB | ZNF775 | BioGRID | empirical | 21900206 |
| PPP2CB | GSTA1 | IntAct | empirical | 21988832 |
| PPP2CB | STRN4 | IntAct, BioGRID | empirical | 19156129 18782753 |
| PPP2CB | MYLPF | BioGRID | empirical | 19156129 |
| PPP2CB | STRN3 | IntAct, BioGRID | empirical | 19156129 18782753 |
| PPP2CB | HK3 | IntAct | empirical | 21988832 |
| PPP2CB | HLA-B | IntAct | empirical | 17353931 |
| PPP2CB | TLX1 | BioGRID | empirical | 9009195 |
| PPP2CB | IGBP1 | IntAct, BioGRID | empirical | 19156129 9647778 18782753 |
| PPP2CB | EIF6 | IntAct | empirical | 17353931 |
| PPP2CB | ARL2 | BioGRID | empirical | 12912990 |
| PPP2CB | MAK | IntAct | empirical | 21988832 |
| PPP2CB | MCC | IntAct | empirical | 17353931 |
| PPP2CB | MYH10 | BioGRID | empirical | 19156129 |
| PPP2CB | PPME1 | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | PFDN2 | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | PFDN5 | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | TRMT61B | IntAct | empirical | 21988832 |
| PPP2CB | PPP2R1A | MINT, IntAct, BioGRID, Reactome | empirical | 15936019 19156129 18782753 20360068 12370081 12593796 11053437 12815057 |
| PPP2CB | PPP2R1B | IntAct, BioGRID, Sanger Interaction Map | empirical | 19156129 12370081 15345047 |
| PPP2CB | PPP2R2A | IntAct, BioGRID | empirical | 19156129 18782753 |
| PPP2CB | PPP2R2B | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | PPP2R5C | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | PPP2R5D | IntAct, BioGRID | empirical | 19156129 18782753 |
| PPP2CB | PPP2R5E | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | PPP4C | IntAct, BioGRID | empirical | 17353931 |
| PPP2CB | PLXNA3 | BioGRID | empirical | 21900206 |
| PPP2CB | PPP2R2D | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | CTTNBP2NL | IntAct, BioGRID | empirical | 18782753 19156129 |
| PPP2CB | MARK4 | IntAct, BioGRID | empirical | 14676191 |
| PPP2CB | RAF1 | IntAct | empirical | 21988832 |
| PPP2CB | RELA | BioGRID | empirical | 11591705 |
| PPP2CB | RPLP1 | BioGRID | empirical | 21900206 |
| PPP2CB | INTS3 | BioGRID | empirical | 20133760 |
| PPP2CB | SLC2A4 | IntAct | empirical | 16396496 |
| PPP2CB | STRN | IntAct, BioGRID | empirical | 19156129 18782753 |
| PPP2CB | TCP1 | IntAct, BioGRID | empirical | 19156129 18782753 |
| PPP2CB | TERF1 | BioGRID | empirical | 20811636 |
| PPP2CB | TFE3 | IntAct | empirical | 17353931 |
| PPP2CB | TRAF6 | IntAct | empirical | 17353931 |
| PPP2CB | CCT3 | IntAct, BioGRID | empirical | 19156129 18782753 |
| PPP2CB | TRPC5 | Sanger Interaction Map | predicted | 15345047 |
| PPP2CB | UBC | BioGRID | empirical | 18781797 21963094 21139048 21890473 21906983 |
| PPP2CB | VBP1 | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | SLMAP | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | PRR14 | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | SIKE1 | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | INTS5 | BioGRID | empirical | 20133760 |
| PPP2CB | TBC1D10A | Sanger Interaction Map | predicted | 15345047 |
| PPP2CB | CTTNBP2 | IntAct, BioGRID | empirical | 18782753 |
| PPP2CB | STK24 | IntAct | empirical | 17353931 |
| PPP2CB | PPFIA1 | IntAct, BioGRID | empirical | 19156129 |
| PPP2CB | FAM40A | IntAct, BioGRID | empirical | 19156129 18782753 |
| PPP2CB | DOCK7 | BioGRID | empirical | 21900206 |
| PPP2CB | DYNLL1 | IntAct, BioGRID | empirical | 20360068 |
| PPP2CB | CCNA1 | IntAct | empirical | 17353931 |
| PPP2CB | CCT6A | IntAct, BioGRID | empirical | 19156129 18782753 |
| PPP2CB | IKBKE | IntAct | empirical | 17353931 |
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Type 1 Diabetes Publications: 1
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Depletion of the catalytic subunit of protein phosphatase-2A (PP2Ac) markedly attenuates glucose-stimulated insulin secretion in pancreatic beta-cells.
Jangati GR, Veluthakal R, Susick L, Gruber SA, Kowluru A
Endocrine. 2007
PubMed ID: 17906371
Publications: 102
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A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
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Protein phosphatase 2A catalytic subunit α (PP2Acα) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway.
Chen W, Gu P, Jiang X, Ruan HB, Li C, Gao X
Am J Pathol. 2011
PubMed ID: 21514445
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The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability.
Park JH, Smith RJ, Shieh SY, Roeder RG
J Biol Chem. 2011
PubMed ID: 21317290
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Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
Greco TM, Yu F, Guise AJ, Cristea IM
Mol Cell Proteomics. 2011
PubMed ID: 21081666
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Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
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Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
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Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A.
Ohama T, Brautigan DL
J Biol Chem. 2010
PubMed ID: 20100830
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Streamlined analysis schema for high-throughput identification of endogenous protein complexes.
Malovannaya A, Li Y, Bulynko Y, Jung SY, Wang Y, Lanz RB, O'Malley BW, Qin J
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133760
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The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.
Giannone RJ, McDonald HW, Hurst GB, Shen RF, Wang Y, Liu Y
PLoS One. 2010
PubMed ID: 20811636
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A mechanism for the suppression of interleukin-1-induced nuclear factor kappaB activation by protein phosphatase 2Ceta-2.
Henmi T, Amano K, Nagaura Y, Matsumoto K, Echigo S, Tamura S, Kobayashi T
Biochem J. 2009
PubMed ID: 19594441
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Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2(-/y) mice.
Pawlowski TL, Heringer-Walther S, Cheng CH, Archie JG, Chen CF, Walther T, Srivastava AK
Genomics. 2009
PubMed ID: 19501643
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GAK, a regulator of clathrin-mediated membrane trafficking, localizes not only in the cytoplasm but also in the nucleus.
Sato J, Shimizu H, Kasama T, Yabuta N, Nojima H
Genes Cells. 2009
PubMed ID: 19371378
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Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding.
Deng X, Gao F, May WS
Blood. 2009
PubMed ID: 18845789
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An integrated workflow for charting the human interaction proteome: insights into the PP2A system.
Glatter T, Wepf A, Aebersold R, Gstaiger M
Mol Syst Biol. 2009
PubMed ID: 19156129
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A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.
Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC
Mol Cell Proteomics. 2009
PubMed ID: 18782753
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Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
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Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
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PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.
Chen R, Liu M, Li H, Xue Y, Ramey WN, He N, Ai N, Luo H, Zhu Y, Zhou N, Zhou Q
Genes Dev. 2008
PubMed ID: 18483222
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Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling.
Gushiken FC, Patel V, Liu Y, Pradhan S, Bergeron AL, Peng Y, Vijayan KV
J Biol Chem. 2008
PubMed ID: 18334487
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I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A.
Chen S, Li B, Grundke-Iqbal I, Iqbal K
J Biol Chem. 2008
PubMed ID: 18245083
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GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
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Protein phosphatase and TRAIL receptor genes as new candidate tumor genes on chromosome 8p in prostate cancer.
Hornstein M, Hoffmann MJ, Alexa A, Yamanaka M, Müller M, Jung V, Rahnenführer J, Schulz WA
Cancer Genomics Proteomics. 2008
PubMed ID: 18460741
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Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.
Ortega-Gutiérrez S, Leung D, Ficarro S, Peters EC, Cravatt BF
PLoS ONE. 2008
PubMed ID: 18596935
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Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
Liu WB, Li Y, Zhang L, Chen HG, Sun S, Liu JP, Liu Y, Li DW
Mol Vis. 2008
PubMed ID: 18432318
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Phosphatase type 2A-dependent and -independent pathways for ATR phosphorylation of Chk1.
Li G, Elder RT, Qin K, Park HU, Liang D, Zhao RY
J Biol Chem. 2007
PubMed ID: 17210576
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Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis.
Saraf A, Virshup DM, Strack S
J Biol Chem. 2007
PubMed ID: 17085438
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Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
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Activation of sodium transport in rat erythrocytes by inhibition of protein phosphatases 1 and 2A.
Ivanova TI, Agalakova NI, Gusev GP
Comp Biochem Physiol B Biochem Mol Biol. 2006
PubMed ID: 16875859
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PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum.
Lin SS, Bassik MC, Suh H, Nishino M, Arroyo JD, Hahn WC, Korsmeyer SJ, Roberts TM
J Biol Chem. 2006
PubMed ID: 16717086
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Shugoshin collaborates with protein phosphatase 2A to protect cohesin.
Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y
Nature. 2006
PubMed ID: 16541025
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Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.
Riedel CG, Katis VL, Katou Y, Mori S, Itoh T, Helmhart W, Gálová M, Petronczki M, Gregan J, Cetin B, Mudrak I, Ogris E, Mechtler K, Pelletier L, Buchholz F, Shirahige K, Nasmyth K
Nature. 2006
PubMed ID: 16541024
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BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
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Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation.
Hall DD, Feekes JA, Arachchige Don AS, Shi M, Hamid J, Chen L, Strack S, Zamponi GW, Horne MC, Hell JW
Biochemistry. 2006
PubMed ID: 16519540
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DNA sequence and analysis of human chromosome 8.
Nusbaum C, Mikkelsen TS, Zody MC, Asakawa S, Taudien S, Garber M, Kodira CD, Schueler MG, Shimizu A, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Allen NR, Anderson S, Asakawa T, Blechschmidt K, Bloom T, Borowsky ML, Butler J, Cook A, Corum B, DeArellano K, DeCaprio D, Dooley KT, Dorris L, Engels R, Glöckner G, Hafez N, Hagopian DS, Hall JL, Ishikawa SK, Jaffe DB, Kamat A, Kudoh J, Lehmann R, Lokitsang T, Macdonald P, Major JE, Matthews CD, Mauceli E, Menzel U, Mihalev AH, Minoshima S, Murayama Y, Naylor JW, Nicol R, Nguyen C, O'Leary SB, O'Neill K, Parker SC, Polley A, Raymond CK, Reichwald K, Rodriguez J, Sasaki T, Schilhabel M, Siddiqui R, Smith CL, Sneddon TP, Talamas JA, Tenzin P, Topham K, Venkataraman V, Wen G, Yamazaki S, Young SK, Zeng Q, Zimmer AR, Rosenthal A, Birren BW, Platzer M, Shimizu N, Lander ES
Nature. 2006
PubMed ID: 16421571
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A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.
Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R
Mol Cell Proteomics. 2005
PubMed ID: 16085932
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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Antiapoptotic activity of Akt is down-regulated by Ca2+ in myocardiac H9c2 cells. Evidence of Ca(2+)-dependent regulation of protein phosphatase 2Ac.
Yasuoka C, Ihara Y, Ikeda S, Miyahara Y, Kondo T, Kohno S
J Biol Chem. 2004
PubMed ID: 15375154
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Phosphatase inhibition potentiates IL-6 production by mast cells in response to FcepsilonRI-mediated activation: involvement of p38 MAPK.
Boudreau RT, Hoskin DW, Lin TJ
J Leukoc Biol. 2004
PubMed ID: 15316034
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The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis.
Kong M, Fox CJ, Mu J, Solt L, Xu A, Cinalli RM, Birnbaum MJ, Lindsten T, Thompson CB
Science. 2004
PubMed ID: 15499020
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits.
Prickett TD, Brautigan DL
J Biol Chem. 2004
PubMed ID: 15252037
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Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 and its physiological implications.
Wei J, Davis KM, Wu H, Wu JY
Biochemistry. 2004
PubMed ID: 15147202
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
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Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G
J Biol Chem. 2004
PubMed ID: 14676191
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
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The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic.
Scott GK, Gu F, Crump CM, Thomas L, Wan L, Xiang Y, Thomas G
EMBO J. 2003
PubMed ID: 14633983
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A.
Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA
J Biol Chem. 2003
PubMed ID: 12912990
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A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
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Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital.
Yoshinari K, Kobayashi K, Moore R, Kawamoto T, Negishi M
FEBS Lett. 2003
PubMed ID: 12885400
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A developmentally regulated, neuron-specific splice variant of the variable subunit Bbeta targets protein phosphatase 2A to mitochondria and modulates apoptosis.
Dagda RK, Zaucha JA, Wadzinski BE, Strack S
J Biol Chem. 2003
PubMed ID: 12716901
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Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice.
Parsons SA, Wilkins BJ, Bueno OF, Molkentin JD
Mol Cell Biol. 2003
PubMed ID: 12773574
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Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution.
Zhou J, Pham HT, Ruediger R, Walter G
Biochem J. 2003
PubMed ID: 12370081
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.
Hrimech M, Yao XJ, Branton PE, Cohen EA
EMBO J. 2002
PubMed ID: 12110603
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Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling.
Ugi S, Imamura T, Ricketts W, Olefsky JM
Mol Cell Biol. 2002
PubMed ID: 11884620
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Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.
Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Gong CX
Neuroscience. 2002
PubMed ID: 12435421
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Regulation of spindle formation by active mitogen-activated protein kinase and protein phosphatase 2A during mouse oocyte meiosis.
Lu Q, Dunn RL, Angeles R, Smith GD
Biol Reprod. 2002
PubMed ID: 11751260
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Protein phosphatase 2A interacts with and directly dephosphorylates RelA.
Yang J, Fan GH, Wadzinski BE, Sakurai H, Richmond A
J Biol Chem. 2001
PubMed ID: 11591705
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An NMDA receptor signaling complex with protein phosphatase 2A.
Chan SF, Sucher NJ
J Neurosci. 2001
PubMed ID: 11588171
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HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.
Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y
Virology. 2001
PubMed ID: 11531413
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Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.
Liu J, Prickett TD, Elliott E, Meroni G, Brautigan DL
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11371618
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Two immunologically distinct human DNA polymerase alpha-primase subpopulations are involved in cellular DNA replication.
Dehde S, Rohaly G, Schub O, Nasheuer HP, Bohn W, Chemnitz J, Deppert W, Dornreiter I
Mol Cell Biol. 2001
PubMed ID: 11259605
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart.
Lüss H, Klein-Wiele O, Bokník P, Herzig S, Knapp J, Linck B, Müller FU, Scheld HH, Schmid C, Schmitz W, Neumann J
J Mol Cell Cardiol. 2000
PubMed ID: 11113010
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Type 2A protein phosphatase, the complex regulator of numerous signaling pathways.
Zolnierowicz S
Biochem Pharmacol. 2000
PubMed ID: 11007961
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
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Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.
Hrimech M, Yao XJ, Branton PE, Cohen EA
EMBO J. 2000
PubMed ID: 10921877
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Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development.
Götz J, Probst A, Mistl C, Nitsch RM, Ehler E
Mech Dev. 2000
PubMed ID: 10781942
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Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
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Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.
De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J
Biochemistry. 1999
PubMed ID: 10600115
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The role of protein phosphatase 2A catalytic subunit Calpha in embryogenesis: evidence from sequence analysis and localization studies.
Götz J, Kues W
Biol Chem. 1999
PubMed ID: 10543450
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Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2.
Chung H, Nairn AC, Murata K, Brautigan DL
Biochemistry. 1999
PubMed ID: 10441131
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A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A.
Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, Pallas DC
J Biol Chem. 1999
PubMed ID: 10318862
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Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.
Hsu W, Zeng L, Costantini F
J Biol Chem. 1999
PubMed ID: 9920888
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42.
Nanahoshi M, Nishiuma T, Tsujishita Y, Hara K, Inui S, Sakaguchi N, Yonezawa K
Biochem Biophys Res Commun. 1998
PubMed ID: 9792806
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Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha.
Götz J, Probst A, Ehler E, Hemmings B, Kues W
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9770493
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Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.
Ruediger R, Brewis N, Ohst K, Walter G
Virology. 1997
PubMed ID: 9400615
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Tissue and subcellular distributions, and characterization of rat brain protein phosphatase 2A containing a 72-kDa delta/B" subunit.
Nagase T, Murakami T, Nozaki H, Inoue R, Nishito Y, Tanabe O, Usui H, Takeda M
J Biochem. 1997
PubMed ID: 9276686
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HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.
Kawabe T, Muslin AJ, Korsmeyer SJ
Nature. 1997
PubMed ID: 9009195
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Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.
Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R
FEBS Lett. 1997
PubMed ID: 9013886
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Differentiation-dependent enhanced expression of protein phosphatase 2Cbeta in germ cells of mouse seminiferous tubules.
Kato S, Kobayashi T, Kusuda K, Nishina Y, Nishimune Y, Yomogida K, Yamamoto M, Sakagami H, Kondo H, Ohnishi M, Chida N, Yanagawa Y, Tamura S
FEBS Lett. 1996
PubMed ID: 8915006
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Protein kinase C is regulated in vivo by three functionally distinct phosphorylations.
Keranen LM, Dutil EM, Newton AC
Curr Biol. 1995
PubMed ID: 8749392
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Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain.
Becker W, Kentrup H, Klumpp S, Schultz JE, Joost HG
J Biol Chem. 1994
PubMed ID: 8077208
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The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.
Favre B, Zolnierowicz S, Turowski P, Hemmings BA
J Biol Chem. 1994
PubMed ID: 8206937
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Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.
Chen J, Parsons S, Brautigan DL
J Biol Chem. 1994
PubMed ID: 7510677
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Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively.
Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT
Cytogenet Cell Genet. 1993
PubMed ID: 8383590
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p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]
Goedert M, Cohen ES, Jakes R, Cohen P
FEBS Lett. 1992
PubMed ID: 1330687
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Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.
Khew-Goodall Y, Mayer RE, Maurer F, Stone SR, Hemmings BA
Biochemistry. 1991
PubMed ID: 1846293
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Multiplicity of protein serine-threonine phosphatases in PC12 pheochromocytoma and FTO-2B hepatoma cells.
Wadzinski BE, Heasley LE, Johnson GL
J Biol Chem. 1990
PubMed ID: 2174876
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Production of shorter mRNA for protein phosphatase 2A beta by alternative poly(A) addition.
Sasaki K, Kitagawa Y, Shima H, Irino S, Sugimura T, Nagao M
Biochem Biophys Res Commun. 1990
PubMed ID: 2164800
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Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.
Pallas DC, Shahrik LK, Martin BL, Jaspers S, Miller TB, Brautigan DL, Roberts TM
Cell. 1990
PubMed ID: 2153055
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Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.
Virshup DM, Kauffman MG, Kelly TJ
EMBO J. 1989
PubMed ID: 2555176
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Nucleotide sequence of a rat heart cDNA encoding the isotype beta of the catalytic subunit of protein phosphatase 2A.
Posas F, Ariño J
Nucleic Acids Res. 1989
PubMed ID: 2554256
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Molecular cloning of rat phosphoprotein phosphatase 2A beta cDNA and increased expressions of phosphatase 2A alpha and 2A beta in rat liver tumors.
Kitagawa Y, Sakai R, Tahira T, Tsuda H, Ito N, Sugimura T, Nagao M
Biochem Biophys Res Commun. 1988
PubMed ID: 2849437
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The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit.
Hemmings BA, Wernet W, Mayer R, Maurer F, Hofsteenge J, Stone SR
Nucleic Acids Res. 1988
PubMed ID: 2849765
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Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.
Arino J, Woon CW, Brautigan DL, Miller TB, Johnson GL
Proc Natl Acad Sci U S A. 1988
PubMed ID: 2837763
Model Organism Phenotype Links
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