T1DBase - A Bioinformatics Resource for Type 1 Diabetes Researchers

Gene Description:

PIN2/TERF1 interacting, telomerase inhibitor 1

Synonyms:

LPTS1, PINX1, Pinx1, 2210403I16Rik, 2610028A01Rik, AU024023, 67-11-3, RGD1566025, LPTS, LPTL

Orthologs:

Human PINX1 (protein-coding), Mouse Pinx1 (protein-coding), Rat Pinx1 (protein-coding)

Sources

(Human) GRCh37 - chr8:10622473..10697394 (74.92 kb) View in Genome Browser

(Mouse) NCBIM37 - chr14:64479149..64538696 (59.55 kb) View in Genome Browser

(Rat) RGSC3.4 - chr15:43124874..43184583 (59.71 kb) View in Genome Browser

HaemAtlas Expression Table for PINX1:

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
			no data

Expression Legend

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Table for PINX1:

View all

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 20

Publications: 44

A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice.
Zhou XZ, Huang P, Shi R, Lee TH, Lu G, Zhang Z, Bronson R, Lu KP
J Clin Invest. 2011
PubMed ID: 21436583
Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation.
Soohoo CY, Shi R, Lee TH, Huang P, Lu KP, Zhou XZ
J Biol Chem. 2011
PubMed ID: 21119197
Plk1-mediated mitotic phosphorylation of PinX1 regulates its stability.
Wang C, Yu J, Yuan K, Lan J, Jin C, Huang H
Eur J Cell Biol. 2010
PubMed ID: 20573420
C-terminal amino acids 290-328 of LPTS/PinX1 confer telomerase inhibition.
Chen G, Da L, Xu Y, Xu M, Song L, Li T, Zhao M
Biochem Biophys Res Commun. 2010
PubMed ID: 20620128
PinX1 inhibits telomerase activity in gastric cancer cells through Mad1/c-Myc pathway.
Wang HB, Wang XW, Zhou G, Wang WQ, Sun YG, Yang SM, Fang DC
J Gastrointest Surg. 2010
PubMed ID: 20544396
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma.
Cai MY, Zhang B, He WP, Yang GF, Rao HL, Rao ZY, Wu QL, Guan XY, Kung HF, Zeng YX, Xie D
Cancer Sci. 2010
PubMed ID: 20367640
Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.
Ikram MK, Xueling S, Jensen RA, Cotch MF, Hewitt AW, Ikram MA, Wang JJ, Klein R, Klein BE, Breteler MM, Cheung N, Liew G, Mitchell P, Uitterlinden AG, Rivadeneira F, Hofman A, de Jong PT, van Duijn CM, Kao L, Cheng CY, Smith AV, Glazer NL, Lumley T, McKnight B, Psaty BM, Jonasson F, Eiriksdottir G, Aspelund T, Global BPgen Consortium, Harris TB, Launer LJ, Taylor KD, Li X, Iyengar SK, Xi Q, Sivakumaran TA, Mackey DA, Macgregor S, Martin NG, Young TL, Bis JC, Wiggins KL, Heckbert SR, Hammond CJ, Andrew T, Fahy S, Attia J, Holliday EG, Scott RJ, Islam FM, Rotter JI, McAuley AK, Boerwinkle E, Tai ES, Gudnason V, Siscovick DS, Vingerling JR, Wong TY
PLoS Genet. 2010
PubMed ID: 21060863
Multiple genetic variants in telomere pathway genes and breast cancer risk.
Shen J, Gammon MD, Wu HC, Terry MB, Wang Q, Bradshaw PT, Teitelbaum SL, Neugut AI, Santella RM
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20056641
PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation.
Yuan K, Li N, Jiang K, Zhu T, Huo Y, Wang C, Lu J, Shaw A, Thomas K, Zhang J, Mann D, Liao J, Jin C, Yao X
J Biol Chem. 2009
PubMed ID: 19553660
PinX1 is recruited to the mitotic chromosome periphery by Nucleolin and facilitates chromosome congression.
Li N, Yuan K, Yan F, Huo Y, Zhu T, Liu X, Guo Z, Yao X
Biochem Biophys Res Commun. 2009
PubMed ID: 19393617
Human PinX1 mediates TRF1 accumulation in nucleolus and enhances TRF1 binding to telomeres.
Yoo JE, Oh BK, Park YN
J Mol Biol. 2009
PubMed ID: 19265708
The correlation of genetic instability of PINX1 gene to clinico-pathological features of gastric cancer in the Chinese population.
Ma Y, Wu L, Liu C, Xu L, Li D, Li JC
J Cancer Res Clin Oncol. 2009
PubMed ID: 18784941
Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells.
Zhang B, Bai YX, Ma HH, Feng F, Jin R, Wang ZL, Lin J, Sun SP, Yang P, Wang XX, Huang PT, Huang CF, Peng Y, Chen YC, Kung HF, Huang JJ
Cancer Res. 2009
PubMed ID: 19117989
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Rat homolog of PinX1 is a nucleolar protein involved in the regulation of telomere length.
Oh BK, Yoon SM, Lee CH, Park YN
Gene. 2007
PubMed ID: 17624691
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
DNA sequence and analysis of human chromosome 8.
Nusbaum C, Mikkelsen TS, Zody MC, Asakawa S, Taudien S, Garber M, Kodira CD, Schueler MG, Shimizu A, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Allen NR, Anderson S, Asakawa T, Blechschmidt K, Bloom T, Borowsky ML, Butler J, Cook A, Corum B, DeArellano K, DeCaprio D, Dooley KT, Dorris L, Engels R, Glöckner G, Hafez N, Hagopian DS, Hall JL, Ishikawa SK, Jaffe DB, Kamat A, Kudoh J, Lehmann R, Lokitsang T, Macdonald P, Major JE, Matthews CD, Mauceli E, Menzel U, Mihalev AH, Minoshima S, Murayama Y, Naylor JW, Nicol R, Nguyen C, O'Leary SB, O'Neill K, Parker SC, Polley A, Raymond CK, Reichwald K, Rodriguez J, Sasaki T, Schilhabel M, Siddiqui R, Smith CL, Sneddon TP, Talamas JA, Tenzin P, Topham K, Venkataraman V, Wen G, Yamazaki S, Young SK, Zeng Q, Zimmer AR, Rosenthal A, Birren BW, Platzer M, Shimizu N, Lander ES
Nature. 2006
PubMed ID: 16421571
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma.
Kondo T, Oue N, Mitani Y, Kuniyasu H, Noguchi T, Kuraoka K, Nakayama H, Yasui W
Oncogene. 2005
PubMed ID: 15637589
A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
McKee AE, Minet E, Stern C, Riahi S, Stiles CD, Silver PA
BMC Dev Biol. 2005
PubMed ID: 16033648
Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR.
Banik SS, Counter CM
J Biol Chem. 2004
PubMed ID: 15381700
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length.
Song H, Li Y, Chen G, Xing Z, Zhao J, Yokoyama KK, Li T, Zhao M
Biochem Biophys Res Commun. 2004
PubMed ID: 15044100
Cloning and characterization of the promoter region of human LPTS/PinX1 gene.
Wang S, Liao C, Li T, Zhao M
Biochim Biophys Acta. 2004
PubMed ID: 14984932
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Mutation analysis of novel human liver-related putative tumor suppressor gene in hepatocellular carcinoma.
Liao C, Zhao MJ, Zhao J, Song H, Pineau P, Marchio A, Dejean A, Tiollais P, Wang HY, Li TP
World J Gastroenterol. 2003
PubMed ID: 12508358
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Over-expression of LPTS-L in hepatocellular carcinoma cell line SMMC-7721 induces crisis.
Liao C, Zhao MJ, Zhao J, Jia D, Song H, Li ZP
World J Gastroenterol. 2002
PubMed ID: 12439923
[The cloning and expression of a novel mouse gene mLPTS and its subcellular localization]
Liao C, Zhao MJ, Li ZP
Yi Chuan Xue Bao. 2002
PubMed ID: 12561469
The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition.
Guglielmi B, Werner M
J Biol Chem. 2002
PubMed ID: 12107183
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.
Zhou XZ, Lu KP
Cell. 2001
PubMed ID: 11701125
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma.
Liao C, Zhao M, Song H, Uchida K, Yokoyama KK, Li T
Hepatology. 2000
PubMed ID: 11003615
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636

Model Organism Phenotype Links

	Human	Mouse	Rat
Entrez Gene	54984	72400	305963
EnsEMBL Gene(s)	ENSG00000254093	ENSMUSG00000021958	ENSRNOG00000012012
Unigene	Hs.490991	Mm.379214	Rn.15365
Homologene	PINX1	Pinx1	Pinx1
OMIM	606505	N/A	N/A
GeneCards	PINX1	N/A	N/A
Beta Cell Genomics	DT.443936 DT.97821639	DT.101376961 DT.97363630	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	54984	72400	305963

Relevant resources:

Interactor	Interactor	Sources	Classification	Pubmed IDs
PINX1	EIF1B	IntAct	empirical	17353931
PINX1	CNPY2	IntAct	empirical	17353931
PINX1	MCRS1	HPRD, BioGRID	empirical	15044100
PINX1	PTGES3	IntAct	empirical	17353931
PINX1	SUB1	IntAct	empirical	17353931
PINX1	POP1	IntAct	empirical	17353931
PINX1	DSTN	IntAct	empirical	17353931
PINX1	RPL35	IntAct	empirical	17353931
PINX1	CSTB	IntAct	empirical	17353931
PINX1	CTPS	IntAct	empirical	17353931
PINX1	DHX9	IntAct	empirical	17353931
PINX1	DUT	IntAct	empirical	17353931
PINX1	AHCY	IntAct, BioGRID	empirical	17353931
PINX1	EIF1AX	IntAct	empirical	17353931
PINX1	FAU	IntAct	empirical	17353931
PINX1	ABCF1	IntAct	empirical	17353931
PINX1	RRP1B	IntAct	empirical	17353931
PINX1	COTL1	IntAct	empirical	17353931
PINX1	GTPBP4	IntAct	empirical	17353931
PINX1	MMS22L	IntAct	empirical	17353931
PINX1	GABPA	IntAct	empirical	21988832
PINX1	PRDX5	IntAct	empirical	17353931
PINX1	RPL36	IntAct	empirical	17353931
PINX1	MYCBP	IntAct	empirical	17353931
PINX1	PABPC1	IntAct, BioGRID	empirical	17353931
PINX1	CACYBP	IntAct	empirical	21988832
PINX1	INVS	IntAct	empirical	17353931
PINX1	HRNR	IntAct	empirical	17353931
PINX1	RHOC	IntAct	empirical	17353931
PINX1	STMN1	IntAct	empirical	17353931
PINX1	CAPRIN1	IntAct, BioGRID	empirical	17353931
PINX1	MAGOH	IntAct	empirical	17353931
PINX1	MCM7	IntAct	empirical	17353931
PINX1	MIF	IntAct	empirical	17353931
PINX1	MPZ	HPRD, MINT, IntAct	empirical	16169070
PINX1	COX2	IntAct	empirical	17353931
PINX1	MYL6	IntAct	empirical	17353931
PINX1	NPM1	IntAct	empirical	17353931
PINX1	PEBP1	IntAct	empirical	17353931
PINX1	PAFAH1B2	HPRD, MINT, IntAct, BioGRID	empirical	16169070
PINX1	MRPS16	IntAct	empirical	17353931
PINX1	MRPS17	IntAct	empirical	17353931
PINX1	CUTA	IntAct	empirical	17353931
PINX1	SF3B14	IntAct	empirical	17353931
PINX1	PFDN2	IntAct	empirical	17353931
PINX1	CYCS	IntAct	empirical	17353931
PINX1	PPIB	IntAct	empirical	17353931
PINX1	PLEKHJ1	IntAct, BioGRID	empirical	17353931
PINX1	SYNJ2BP	IntAct	empirical	17353931
PINX1	TSR1	IntAct	empirical	17353931
PINX1	WWC3	IntAct	empirical	17353931
PINX1	PSMB5	IntAct	empirical	17353931
PINX1	RPL18A	IntAct	empirical	17353931
PINX1	RPL22	IntAct	empirical	17353931
PINX1	RPL23A	IntAct, BioGRID	empirical	17353931
PINX1	RPL24	IntAct	empirical	17353931
PINX1	RPL26	IntAct	empirical	17353931
PINX1	RPL29	IntAct	empirical	17353931
PINX1	RPL31	IntAct, BioGRID	empirical	17353931
PINX1	RPL32	IntAct	empirical	17353931
PINX1	RPL35A	IntAct	empirical	17353931
PINX1	RPL37A	IntAct	empirical	17353931
PINX1	RPS3A	IntAct, BioGRID	empirical	17353931
PINX1	RPS10	IntAct, BioGRID	empirical	17353931
PINX1	RPS11	IntAct	empirical	17353931
PINX1	RPS14	IntAct	empirical	17353931
PINX1	RPS16	IntAct, BioGRID	empirical	17353931
PINX1	RPS19	IntAct, BioGRID	empirical	17353931
PINX1	RPS26	IntAct	empirical	17353931
PINX1	RPS28	IntAct, BioGRID	empirical	17353931
PINX1	MRPS14	IntAct	empirical	17353931
PINX1	AIDA	BioGRID	empirical	21900206
PINX1	SRP14	IntAct	empirical	17353931
PINX1	SRP72	IntAct	empirical	17353931
PINX1	SSR3	IntAct	empirical	17353931
PINX1	ST13	IntAct	empirical	17353931
PINX1	BTF3	IntAct	empirical	17353931
PINX1	TCEB1	IntAct	empirical	17353931
PINX1	TERF1	HPRD, MINT, BioGRID	empirical	11701125
PINX1	TERT	BioGRID	empirical	11701125
PINX1	TXN	IntAct, BioGRID	empirical	17353931
PINX1	UBC	BioGRID	empirical	21139048
PINX1	UBE2L3	IntAct	empirical	17353931
PINX1	UBE2N	IntAct	empirical	17353931
PINX1	EZR	IntAct	empirical	17353931
PINX1	DDX50	IntAct	empirical	17353931
PINX1	EPPK1	IntAct	empirical	17353931
PINX1	TAGLN2	IntAct	empirical	17353931
PINX1	TP63	IntAct	empirical	21988832
PINX1	PABPC4	IntAct, BioGRID	empirical	17353931
PINX1	DDX18	IntAct	empirical	17353931
PINX1	DDX21	IntAct	empirical	17353931
PINX1	MAPKAPK2	IntAct	empirical	17353931
PINX1	VAMP3	IntAct	empirical	17353931
PINX1	COX5A	IntAct	empirical	17353931