Home MED1
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Regions Overlapping this Feature:
Human: 1
Mouse: 1
Rat: 1
Associated Regions: 1 Available
Other Regions: 2 Available
Associated Regions: 1 Available
Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.
| Region | Species | Chromosomal Location | Mb | Number of genes | Marker |
|---|---|---|---|---|---|
| 17q12 | Human | chr17:37380642..38254492 | 0.87 | 27 | rs2290400 rs12150079 |
Other Regions: 2 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes |
|---|---|---|---|---|
| Human 17q12 Orthologous Region | Mouse | chr11:97916652..98637714 | 0.72 | 27 |
| Human 17q12 Orthologous Region | Rat | chr10:86818764..87546753 | 0.73 | 20 |
(Human) GRCh37 - chr17:37560538..37607527 (46.99 kb) View in Genome Browser
(Mouse) NCBIM37 - chr11:98013468..98054607 (41.14 kb) View in Genome Browser
(Rat) RGSC3.4 - chr10:86915421..86959422 (44 kb) View in Genome Browser
HaemAtlas Expression Table for MED1:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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Expression Legend
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for MED1:The MED1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
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Type 1 Diabetes Publications: 1
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Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus.
Shaat N, Ekelund M, Lernmark A, Ivarsson S, Nilsson A, Perfekt R, Berntorp K, Groop L
Diabetologia. 2004
PubMed ID: 15095040
Publications: 193
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Essential role of Mediator subunit Med1 in invariant natural killer T-cell development.
Yue X, Izcue A, Borggrefe T
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21949387
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A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
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Arginine and Glutamate-rich 1 (ARGLU1) Interacts with Mediator Subunit 1 (MED1) and Is Required for Estrogen Receptor-mediated Gene Transcription and Breast Cancer Cell Growth.
Zhang D, Jiang P, Xu Q, Zhang X
J Biol Chem. 2011
PubMed ID: 21454576
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Transcription coactivator mediator subunit MED1 is required for the development of fatty liver in the mouse.
Bai L, Jia Y, Viswakarma N, Huang J, Vluggens A, Wolins NE, Jafari N, Rao MS, Borensztajn J, Yang G, Reddy JK
Hepatology. 2011
PubMed ID: 21480322
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Genetic variations strongly influence phenotypic outcome in the mouse retina.
Jelcick AS, Yuan Y, Leehy BD, Cox LC, Silveira AC, Qiu F, Schenk S, Sachs AJ, Morrison MA, Nystuen AM, DeAngelis MM, Haider NB
PLoS One. 2011
PubMed ID: 21779340
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Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth.
Chen Z, Zhang C, Wu D, Chen H, Rorick A, Zhang X, Wang Q
EMBO J. 2011
PubMed ID: 21556051
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Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1.
Stumpf M, Yue X, Schmitz S, Luche H, Reddy JK, Borggrefe T
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21098667
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The transcriptional mediator subunit MED1/TRAP220 in stromal cells is involved in hematopoietic stem/progenitor cell support through osteopontin expression.
Sumitomo A, Ishino R, Urahama N, Inoue K, Yonezawa K, Hasegawa N, Horie O, Matsuoka H, Kondo T, Roeder RG, Ito M
Mol Cell Biol. 2010
PubMed ID: 20713445
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Defining the epigenetic actions of growth hormone: acute chromatin changes accompany GH-activated gene transcription.
Chia DJ, Rotwein P
Mol Endocrinol. 2010
PubMed ID: 20702579
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Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
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The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiation.
Oda Y, Chalkley RJ, Burlingame AL, Bikle DD
J Invest Dermatol. 2010
PubMed ID: 20520624
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ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.
Krebs AR, Demmers J, Karmodiya K, Chang NC, Chang AC, Tora L
EMBO Rep. 2010
PubMed ID: 20508642
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Theoretical study of molecular mechanism of binding TRAP220 coactivator to Retinoid X Receptor alpha, activated by 9-cis retinoic acid.
Kurcinski M, Kolinski A
J Steroid Biochem Mol Biol. 2010
PubMed ID: 20398753
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Activator-Mediator binding regulates Mediator-cofactor interactions.
Ebmeier CC, Taatjes DJ
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20534441
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A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism.
Chen W, Zhang X, Birsoy K, Roeder RG
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20479251
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Vitamin D receptor rs2228570 polymorphism and invasive ovarian carcinoma risk: Pooled analysis in five studies within the Ovarian Cancer Association Consortium.
Lurie G, Wilkens LR, Thompson PJ, Carney ME, Palmieri RT, Pharoah PD, Song H, Hogdall E, Kjaer SK, Dicioccio RA, McGuire V, Whittemore AS, Gayther SA, Gentry-Maharaj A, Menon U, Ramus SJ, Goodman MT, on behalf of the Ovarian Cancer Association Consortium
Int J Cancer. 2010
PubMed ID: 20473893
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Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation.
Jiang P, Hu Q, Ito M, Meyer S, Waltz S, Khan S, Roeder RG, Zhang X
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20351249
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An Oct4-centered protein interaction network in embryonic stem cells.
van den Berg DL, Snoek T, Mullin NP, Yates A, Bezstarosti K, Demmers J, Chambers I, Poot RA
Cell Stem Cell. 2010
PubMed ID: 20362541
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Differential coregulator requirements for function of the hematopoietic transcription factor GATA-1 at endogenous loci.
Pope NJ, Bresnick EH
Nucleic Acids Res. 2010
PubMed ID: 20047963
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An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
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An RNA interference screen identifies metabolic regulators NR1D1 and PBP as novel survival factors for breast cancer cells with the ERBB2 signature.
Kourtidis A, Jain R, Carkner RD, Eifert C, Brosnan MJ, Conklin DS
Cancer Res. 2010
PubMed ID: 20160030
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Streamlined analysis schema for high-throughput identification of endogenous protein complexes.
Malovannaya A, Li Y, Bulynko Y, Jung SY, Wang Y, Lanz RB, O'Malley BW, Qin J
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133760
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CDK8 is a positive regulator of transcriptional elongation within the serum response network.
Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM
Nat Struct Mol Biol. 2010
PubMed ID: 20098423
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Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse.
Matsumoto K, Huang J, Viswakarma N, Bai L, Jia Y, Zhu YT, Yang G, Borensztajn J, Rao MS, Zhu YJ, Reddy JK
Carcinogenesis. 2010
PubMed ID: 20007298
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Peroxisome-proliferator-activated receptor-binding protein (PBP) is essential for the growth of active Notch4-immortalized mammary epithelial cells by activating SOX10 expression.
Zhu YT, Jia Y, Hu L, Qi C, Prasad MK, McCallion AS, Zhu YJ
Biochem J. 2010
PubMed ID: 19852756
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A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
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Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
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Down-regulation of the transcriptional mediator subunit Med1 contributes to the loss of expression of metastasis-associated dapk1 in human cancers and cancer cells.
Gade P, Singh AK, Roy SK, Reddy SP, Kalvakolanu DV
Int J Cancer. 2009
PubMed ID: 19521987
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Dynamic interactions and cooperative functions of PGC-1alpha and MED1 in TRalpha-mediated activation of the brown-fat-specific UCP-1 gene.
Chen W, Yang Q, Roeder RG
Mol Cell. 2009
PubMed ID: 19782026
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Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation.
Zippo A, Serafini R, Rocchigiani M, Pennacchini S, Krepelova A, Oliviero S
Cell. 2009
PubMed ID: 19766566
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The mediator complex subunit 1 enhances transcription of genes needed for adrenal androgen production.
Nakamura Y, Xing Y, Sasano H, Rainey WE
Endocrinology. 2009
PubMed ID: 19497978
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Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
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Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
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Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
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The PPARgamma2 A/B-domain plays a gene-specific role in transactivation and cofactor recruitment.
Bugge A, Grøntved L, Aagaard MM, Borup R, Mandrup S
Mol Endocrinol. 2009
PubMed ID: 19282365
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Down-regulation of the expression of RB18A/MED1, a cofactor of transcription, triggers strong tumorigenic phenotype of human melanoma cells.
Ndong Jde L, Jean D, Rousselet N, Frade R
Int J Cancer. 2009
PubMed ID: 19243021
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk.
Ahn J, Albanes D, Berndt SI, Peters U, Chatterjee N, Freedman ND, Abnet CC, Huang WY, Kibel AS, Crawford ED, Weinstein SJ, Chanock SJ, Schatzkin A, Hayes RB, Prostate, Lung, Colorectal and Ovarian Trial Project Team
Carcinogenesis. 2009
PubMed ID: 19255064
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Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
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Conditional ablation of mediator subunit MED1 (MED1/PPARBP) gene in mouse liver attenuates glucocorticoid receptor agonist dexamethasone-induced hepatic steatosis.
Jia Y, Viswakarma N, Fu T, Yu S, Rao MS, Borensztajn J, Reddy JK
Gene Expr. 2009
PubMed ID: 19630272
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Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.
Haiman CA, Garcia RR, Hsu C, Xia L, Ha H, Sheng X, Le Marchand L, Kolonel LN, Henderson BE, Stallcup MR, Greene GL, Press MF
BMC Cancer. 2009
PubMed ID: 19183483
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Epigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancer.
Howard JH, Frolov A, Tzeng CW, Stewart A, Midzak A, Majmundar A, Godwin A, Heslin M, Bellacosa A, Arnoletti JP
Cancer Biol Ther. 2009
PubMed ID: 19127118
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Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.
Cortellino S, Wang C, Wang B, Bassi MR, Caretti E, Champeval D, Calmont A, Jarnik M, Burch J, Zaret KS, Larue L, Bellacosa A
Dev Biol. 2009
PubMed ID: 19000668
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Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: A two-stage Spanish case-control study.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A
Gynecol Oncol. 2008
PubMed ID: 18950845
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Dominant and redundant functions of TFIID involved in the regulation of hepatic genes.
Tatarakis A, Margaritis T, Martinez-Jimenez CP, Kouskouti A, Mohan WS, Haroniti A, Kafetzopoulos D, Tora L, Talianidis I
Mol Cell. 2008
PubMed ID: 18722179
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Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
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Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation.
Ding N, Zhou H, Esteve PO, Chin HG, Kim S, Xu X, Joseph SM, Friez MJ, Schwartz CE, Pradhan S, Boyer TG
Mol Cell. 2008
PubMed ID: 18691967
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A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
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Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
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MED1 phosphorylation promotes its association with mediator: implications for nuclear receptor signaling.
Belakavadi M, Pandey PK, Vijayvargia R, Fondell JD
Mol Cell Biol. 2008
PubMed ID: 18391015
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Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.
Meyer KD, Donner AJ, Knuesel MT, York AG, Espinosa JM, Taatjes DJ
EMBO J. 2008
PubMed ID: 18418385
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The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gamma.
Li H, Gade P, Nallar SC, Raha A, Roy SK, Karra S, Reddy JK, Reddy SP, Kalvakolanu DV
J Biol Chem. 2008
PubMed ID: 18339625
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GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
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1alpha,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex.
Carvallo L, Henríquez B, Paredes R, Olate J, Onate S, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M
J Cell Physiol. 2008
PubMed ID: 17786964
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Phosphorylation of the human retinoid X receptor alpha at serine 260 impairs coactivator(s) recruitment and induces hormone resistance to multiple ligands.
Macoritto M, Nguyen-Yamamoto L, Huang DC, Samuel S, Yang XF, Wang TT, White JH, Kremer R
J Biol Chem. 2008
PubMed ID: 18003614
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Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression.
Ge K, Cho YW, Guo H, Hong TB, Guermah M, Ito M, Yu H, Kalkum M, Roeder RG
Mol Cell Biol. 2008
PubMed ID: 18039840
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STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation.
Liu X, Vorontchikhina M, Wang YL, Faiola F, Martinez E
Mol Cell Biol. 2008
PubMed ID: 17967894
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Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver.
Guo D, Sarkar J, Suino-Powell K, Xu Y, Matsumoto K, Jia Y, Yu S, Khare S, Haldar K, Rao MS, Foreman JE, Monga SP, Peters JM, Xu HE, Reddy JK
J Biol Chem. 2007
PubMed ID: 17962186
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EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
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MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation.
Lee HK, Park UH, Kim EJ, Um SJ
EMBO J. 2007
PubMed ID: 17641689
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The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis.
Feige JN, Gelman L, Rossi D, Zoete V, Métivier R, Tudor C, Anghel SI, Grosdidier A, Lathion C, Engelborghs Y, Michielin O, Wahli W, Desvergne B
J Biol Chem. 2007
PubMed ID: 17468099
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A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.
Mu JJ, Wang Y, Luo H, Leng M, Zhang J, Yang T, Besusso D, Jung SY, Qin J
J Biol Chem. 2007
PubMed ID: 17478428
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Critical role for transcription coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein/TRAP220 in liver regeneration and PPARalpha ligand-induced liver tumor development.
Matsumoto K, Yu S, Jia Y, Ahmed MR, Viswakarma N, Sarkar J, Kashireddy PV, Rao MS, Karpus W, Gonzalez FJ, Reddy JK
J Biol Chem. 2007
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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ
Science. 2007
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The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs.
Zella LA, Chang CY, McDonnell DP, Wesley Pike J
Arch Biochem Biophys. 2007
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Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3.
Hawker NP, Pennypacker SD, Chang SM, Bikle DD
J Invest Dermatol. 2007
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Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation.
Oda Y, Ishikawa MH, Hawker NP, Yun QC, Bikle DD
J Steroid Biochem Mol Biol. 2007
PubMed ID: 17223341
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The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation.
Chen W, Roeder RG
Nucleic Acids Res. 2007
PubMed ID: 17827210
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HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer.
Benusiglio PR, Pharoah PD, Smith PL, Lesueur F, Conroy D, Luben RN, Dew G, Jordan C, Dunning A, Easton DF, Ponder BA
Br J Cancer. 2006
PubMed ID: 17117180
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The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220.
Stumpf M, Waskow C, Krötschel M, van Essen D, Rodriguez P, Zhang X, Guyot B, Roeder RG, Borggrefe T
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17132730
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Mediator modulates Gli3-dependent Sonic hedgehog signaling.
Zhou H, Kim S, Ishii S, Boyer TG
Mol Cell Biol. 2006
PubMed ID: 17000779
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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
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Decreased expression of thyroid receptor-associated protein 220 in temporal lobe tissue of patients with refractory epilepsy.
Li JM, Wang XF, Xi ZQ, Gong Y, Liu FY, Sun JJ, Wu Y, Luan GM, Wang YP, Li YL, Zhang JG, Lu Y, Li HW
Biochem Biophys Res Commun. 2006
PubMed ID: 16934225
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A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP
Nat Biotechnol. 2006
PubMed ID: 16964243
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Targeted disruption of the synovial sarcoma-associated SS18 gene causes early embryonic lethality and affects PPARBP expression.
de Bruijn DR, Peters WJ, Chuva de Sousa Lopes SM, van Dijk AH, Willemse MP, Pfundt R, de Boer P, Geurts van Kessel A
Hum Mol Genet. 2006
PubMed ID: 16926188
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Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver.
Guo D, Sarkar J, Ahmed MR, Viswakarma N, Jia Y, Yu S, Sambasiva Rao M, Reddy JK
Biochem Biophys Res Commun. 2006
PubMed ID: 16828057
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An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.
Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol C, Iyer L, Tjian R, van den Heuvel S, Hart AC, Wagner G, Näär AM
Nature. 2006
PubMed ID: 16799563
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Distinct roles of the steroid receptor coactivator 1 and of MED1 in retinoid-induced transcription and cellular differentiation.
Flajollet S, Lefebvre B, Rachez C, Lefebvre P
J Biol Chem. 2006
PubMed ID: 16723356
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Regulation of Aurora-A kinase gene expression via GABP recruitment of TRAP220/MED1.
Udayakumar TS, Belakavadi M, Choi KH, Pandey PK, Fondell JD
J Biol Chem. 2006
PubMed ID: 16574658
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PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex.
Surapureddi S, Viswakarma N, Yu S, Guo D, Rao MS, Reddy JK
Biochem Biophys Res Commun. 2006
PubMed ID: 16554032
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MED220/thyroid receptor-associated protein 220 functions as a transcriptional coactivator with Pit-1 and GATA-2 on the thyrotropin-beta promoter in thyrotropes.
Gordon DF, Tucker EA, Tundwal K, Hall H, Wood WM, Ridgway EC
Mol Endocrinol. 2006
PubMed ID: 16396960
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Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT
Hum Mol Genet. 2006
PubMed ID: 16537572
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BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
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MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor.
Chen W, Rogatsky I, Garabedian MJ
Mol Endocrinol. 2006
PubMed ID: 16239257
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Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor.
Saramäki A, Banwell CM, Campbell MJ, Carlberg C
Nucleic Acids Res. 2006
PubMed ID: 16434701
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Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.
Hassa PO, Haenni SS, Buerki C, Meier NI, Lane WS, Owen H, Gersbach M, Imhof R, Hottiger MO
J Biol Chem. 2005
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Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting.
Hall JM, McDonnell DP
Mol Interv. 2005
PubMed ID: 16394250
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The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation.
Urahama N, Ito M, Sada A, Yakushijin K, Yamamoto K, Okamura A, Minagawa K, Hato A, Chihara K, Roeder RG, Matsui T
Genes Cells. 2005
PubMed ID: 16324150
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Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation.
Pandey PK, Udayakumar TS, Lin X, Sharma D, Shapiro PS, Fondell JD
Mol Cell Biol. 2005
PubMed ID: 16314496
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Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.
Baillat D, Hakimi MA, Näär AM, Shilatifard A, Cooch N, Shiekhattar R
Cell. 2005
PubMed ID: 16239144
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of Crabp1 dependent on MED1/TRAP220.
Park SW, Li G, Lin YP, Barrero MJ, Ge K, Roeder RG, Wei LN
Mol Cell. 2005
PubMed ID: 16137621
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WW domains provide a platform for the assembly of multiprotein networks.
Ingham RJ, Colwill K, Howard C, Dettwiler S, Lim CS, Yu J, Hersi K, Raaijmakers J, Gish G, Mbamalu G, Taylor L, Yeung B, Vassilovski G, Amin M, Chen F, Matskova L, Winberg G, Ernberg I, Linding R, O'donnell P, Starostine A, Keller W, Metalnikov P, Stark C, Pawson T
Mol Cell Biol. 2005
PubMed ID: 16055720
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MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.
Zhang X, Krutchinsky A, Fukuda A, Chen W, Yamamura S, Chait BT, Roeder RG
Mol Cell. 2005
PubMed ID: 15989967
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Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3.
Väisänen S, Dunlop TW, Sinkkonen L, Frank C, Carlberg C
J Mol Biol. 2005
PubMed ID: 15919092
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The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor alpha.
Wada-Hiraike O, Yano T, Nei T, Matsumoto Y, Nagasaka K, Takizawa S, Oishi H, Arimoto T, Nakagawa S, Yasugi T, Kato S, Taketani Y
Br J Cancer. 2005
PubMed ID: 15886699
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Gene expression differences in mice divergently selected for methamphetamine sensitivity.
Palmer AA, Verbitsky M, Suresh R, Kamens HM, Reed CL, Li N, Burkhart-Kasch S, McKinnon CS, Belknap JK, Gilliam TC, Phillips TJ
Mamm Genome. 2005
PubMed ID: 16104378
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Role of type I IFNs in pulmonary complications of Pneumocystis murina infection.
Meissner NN, Swain S, Tighe M, Harmsen A, Harmsen A
J Immunol. 2005
PubMed ID: 15843544
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RB18A enhances expression of mutant p53 protein in human cells.
Lottin-Divoux S, Barel M, Frade R
FEBS Lett. 2005
PubMed ID: 15848166
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Peroxisome proliferator-activated receptor-binding protein null mutation results in defective mammary gland development.
Jia Y, Qi C, Zhang Z, Zhu YT, Rao SM, Zhu YJ
J Biol Chem. 2005
PubMed ID: 15647257
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Amino acids important for ligand specificity of the human constitutive androstane receptor.
Jyrkkärinne J, Windshügel B, Mäkinen J, Ylisirniö M, Peräkylä M, Poso A, Sippl W, Honkakoski P
J Biol Chem. 2005
PubMed ID: 15572376
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Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.
Guan HP, Ishizuka T, Chui PC, Lehrke M, Lazar MA
Genes Dev. 2005
PubMed ID: 15681609
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Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
Albers M, Kranz H, Kober I, Kaiser C, Klink M, Suckow J, Kern R, Koegl M
Mol Cell Proteomics. 2005
PubMed ID: 15604093
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Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.
Pogenberg V, Guichou JF, Vivat-Hannah V, Kammerer S, Pérez E, Germain P, de Lera AR, Gronemeyer H, Royer CA, Bourguet W
J Biol Chem. 2005
PubMed ID: 15528208
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Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter.
Sinkkonen L, Malinen M, Saavalainen K, Väisänen S, Carlberg C
Nucleic Acids Res. 2005
PubMed ID: 15863722
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Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
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Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
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Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins.
Wu Q, Burghardt R, Safe S
J Biol Chem. 2004
PubMed ID: 15471764
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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Differential effects of ethanol on gamma-aminobutyric acid-A receptor-mediated synaptic currents in congenic strains of inbred long and short-sleep mice.
Proctor WR, Wu PH, Bennett B, Johnson TE
Alcohol Clin Exp Res. 2004
PubMed ID: 15365296
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Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S
Genome Res. 2004
PubMed ID: 15342556
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Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.
Malik S, Guermah M, Yuan CX, Wu W, Yamamura S, Roeder RG
Mol Cell Biol. 2004
PubMed ID: 15340084
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Identification of DRIP205 as a coactivator for the Farnesoid X receptor.
Pineda Torra I, Freedman LP, Garabedian MJ
J Biol Chem. 2004
PubMed ID: 15187081
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Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15302935
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BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220.
Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S
Oncogene. 2004
PubMed ID: 15208681
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A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.
Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC
Mol Cell. 2004
PubMed ID: 15175163
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Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver.
Jia Y, Qi C, Kashireddi P, Surapureddi S, Zhu YJ, Rao MS, Le Roith D, Chambon P, Gonzalez FJ, Reddy JK
J Biol Chem. 2004
PubMed ID: 15150259
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
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The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator.
Yang F, DeBeaumont R, Zhou S, Näär AM
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14983011
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A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.
Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW
J Biol Chem. 2004
PubMed ID: 14638676
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A novel docking site on Mediator is critical for activation by VP16 in mammalian cells.
Mittler G, Stühler T, Santolin L, Uhlmann T, Kremmer E, Lottspeich F, Berti L, Meisterernst M
EMBO J. 2003
PubMed ID: 14657022
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The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development.
Landles C, Chalk S, Steel JH, Rosewell I, Spencer-Dene B, Lalani el-N, Parker MG
Mol Endocrinol. 2003
PubMed ID: 14500757
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.
Wallberg AE, Yamamura S, Malik S, Spiegelman BM, Roeder RG
Mol Cell. 2003
PubMed ID: 14636573
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Functional genetic analysis of mouse chromosome 11.
Kile BT, Hentges KE, Clark AT, Nakamura H, Salinger AP, Liu B, Box N, Stockton DW, Johnson RL, Behringer RR, Bradley A, Justice MJ
Nature. 2003
PubMed ID: 12955145
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2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 potently stimulates gene-specific DNA binding of the vitamin D receptor in osteoblasts.
Yamamoto H, Shevde NK, Warrier A, Plum LA, DeLuca HF, Pike JW
J Biol Chem. 2003
PubMed ID: 12796488
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Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells.
Fujita T, Kobayashi Y, Wada O, Tateishi Y, Kitada L, Yamamoto Y, Takashima H, Murayama A, Yano T, Baba T, Kato S, Kawabe Y, Yanagisawa J
J Biol Chem. 2003
PubMed ID: 12738788
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Transcriptional coactivator PRIP, the peroxisome proliferator-activated receptor gamma (PPARgamma)-interacting protein, is required for PPARgamma-mediated adipogenesis.
Qi C, Surapureddi S, Zhu YJ, Yu S, Kashireddy P, Rao MS, Reddy JK
J Biol Chem. 2003
PubMed ID: 12754253
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The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome.
Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S
Cell. 2003
PubMed ID: 12837248
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Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.
Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW
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Triiodothyronine increases brain natriuretic peptide (BNP) gene transcription and amplifies endothelin-dependent BNP gene transcription and hypertrophy in neonatal rat ventricular myocytes.
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An extended LXXLL motif sequence determines the nuclear receptor binding specificity of TRAP220.
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J Biol Chem. 2003
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BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Phosphorylation of transcriptional coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP). Stimulation of transcriptional regulation by mitogen-activated protein kinase.
Misra P, Owuor ED, Li W, Yu S, Qi C, Meyer K, Zhu YJ, Rao MS, Kong AN, Reddy JK
J Biol Chem. 2002
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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Nature. 2002
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Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract.
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Mol Cell Biol. 2002
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A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.
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J Biol Chem. 2002
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The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment.
Wansa KD, Harris JM, Muscat GE
J Biol Chem. 2002
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Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.
Surapureddi S, Yu S, Bu H, Hashimoto T, Yeldandi AV, Kashireddy P, Cherkaoui-Malki M, Qi C, Zhu YJ, Rao MS, Reddy JK
Proc Natl Acad Sci U S A. 2002
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Comparative distribution of the mammalian mediator subunit thyroid hormone receptor-associated protein (TRAP220) mRNA in developing and adult rodent brain.
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Eur J Neurosci. 2002
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Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein.
Crowley TE, Kaine EM, Yoshida M, Nandi A, Wolgemuth DJ
Mol Endocrinol. 2002
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TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4.
Malik S, Wallberg AE, Kang YK, Roeder RG
Mol Cell Biol. 2002
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TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA.
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Genes Dev. 2002
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The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development.
Ito M, Okano HJ, Darnell RB, Roeder RG
EMBO J. 2002
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Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205.
Maeda Y, Rachez C, Hawel L, Byus CV, Freedman LP, Sladek FM
Mol Endocrinol. 2002
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Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo.
Sharma D, Fondell JD
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12034878
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A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
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Science. 2002
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Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation.
Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK
J Biol Chem. 2002
PubMed ID: 11912212
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Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.
Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM, Roeder RG
Nature. 2002
PubMed ID: 12037571
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The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro.
Kang YK, Guermah M, Yuan CX, Roeder RG
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11867769
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Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors.
Crawford SE, Qi C, Misra P, Stellmach V, Rao MS, Engel JD, Zhu Y, Reddy JK
J Biol Chem. 2002
PubMed ID: 11724781
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RB18A regulates p53-dependent apoptosis.
Frade R, Balbo M, Barel M
Oncogene. 2002
PubMed ID: 11840331
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Multiplexed molecular interactions of nuclear receptors using fluorescent microspheres.
Iannone MA, Consler TG, Pearce KH, Stimmel JB, Parks DJ, Gray JG
Cytometry. 2001
PubMed ID: 11500849
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High-throughput sequence identification of gene coding variants within alcohol-related QTLs.
Ehringer MA, Thompson J, Conroy O, Xu Y, Yang F, Canniff J, Beeson M, Gordon L, Bennett B, Johnson TE, Sikela JM
Mamm Genome. 2001
PubMed ID: 11471062
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Differential recruitment of the mammalian mediator subunit TRAP220 by estrogen receptors ERalpha and ERbeta.
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J Biol Chem. 2001
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Novel glucocorticoid receptor coactivator effector mechanisms.
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Trends Endocrinol Metab. 2001
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Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140.
Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA
Mol Endocrinol. 2001
PubMed ID: 11266503
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Functional annotation of a full-length mouse cDNA collection.
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Nature. 2001
PubMed ID: 11217851
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RB18A, whose gene is localized on chromosome 17q12-q21.1, regulates in vivo p53 transactivating activity.
Frade R, Balbo M, Barel M
Cancer Res. 2000
PubMed ID: 11118038
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Temporal formation of distinct thyroid hormone receptor coactivator complexes in HeLa cells.
Sharma D, Fondell JD
Mol Endocrinol. 2000
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators.
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Mol Cell Biol. 2000
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Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators.
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J Biol Chem. 2000
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
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Three amino acids specify coactivator choice by retinoid X receptors.
Shao G, Heyman RA, Schulman IG
Mol Endocrinol. 2000
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Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
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Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex.
Burakov D, Wong CW, Rachez C, Cheskis BJ, Freedman LP
J Biol Chem. 2000
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Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality.
Zhu Y, Qi C, Jia Y, Nye JS, Rao MS, Reddy JK
J Biol Chem. 2000
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Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription.
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Proc Natl Acad Sci U S A. 2000
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The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs.
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Mol Cell. 2000
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Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action.
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Mol Cell. 2000
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The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes.
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Mol Cell Biol. 2000
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Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins.
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EMBO J. 1999
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Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer.
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Proc Natl Acad Sci U S A. 1999
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Mol Endocrinol. 1999
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Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors.
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Composite co-activator ARC mediates chromatin-directed transcriptional activation.
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Nature. 1999
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Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.
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Nature. 1999
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Competition between thyroid hormone receptor-associated protein (TRAP) 220 and transcriptional intermediary factor (TIF) 2 for binding to nuclear receptors. Implications for the recruitment of TRAP and p160 coactivator complexes.
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Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.
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Mol Cell. 1999
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The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1.
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Nature. 1999
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High-efficiency full-length cDNA cloning.
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Methods Enzymol. 1999
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A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.
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Differential expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and its coactivators steroid receptor coactivator-1 and PPAR-binding protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse.
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Am J Pathol. 1998
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The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion.
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Proc Natl Acad Sci U S A. 1998
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Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53.
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Oncogene. 1997
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Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor.
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Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.
Fondell JD, Ge H, Roeder RG
Proc Natl Acad Sci U S A. 1996
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Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.
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