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POU5F1

Gene Description:   POU domain, class 5, transcription factor 1; POU class 5 homeobox 1 Synonyms:   Otf3-rs7, Oct3/4, Otf-4, Oct-3, OTF4, Oct-3/4, OCT3, OCT4, Otf4, Oct3, Oct-4, MGC22487, OTF-3, Oct4, Otf3, OTF3, Otf3g, POU5F1, Otf-3, Pou5f1 Orthologs:   Human POU5F1 (protein-coding), Mouse Pou5f1 (protein-coding), Rat Pou5f1 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid Human-Rat: HomoloGene, MGD, RGD Mouse-Rat: HomoloGene, MGD, RGD Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

(Human) GRCh37 - chr6:31132114..31148508 (16.39 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr17:35642982..35647722 (4.74 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas                 no data no data no data no data no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for POU5F1: The POU5F1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs POU5F1   SAE1   BioGRID  empirical  17097055  POU5F1   TRIM28   BioGRID  empirical  20508149  POU5F1   AKAP8   BioGRID  empirical  20362541  POU5F1   RBM14   BioGRID  empirical  20362541  POU5F1   ARID3B   IntAct, BioGRID  empirical  20362542  20362541  17093407  POU5F1   NUDC   IntAct, BioGRID  empirical  20362542  POU5F1   CHD1   IntAct, BioGRID  empirical  20362542  POU5F1   CHD3   IntAct  empirical  20362542  POU5F1   CHD4   IntAct, BioGRID  empirical  20362542  20362541  POU5F1   WDR5   IntAct, BioGRID  empirical  21477851  20362541  POU5F1   KAT7   IntAct, BioGRID  empirical  20362542  POU5F1   SUPT16H   IntAct, BioGRID  empirical  20362542  POU5F1   NACC1   BioGRID  empirical  20362541  17093407  POU5F1   FOXP4   BioGRID  empirical  20362541  POU5F1   C17orf49   BioGRID  empirical  20362541  POU5F1   HIST3H2BB   IntAct, BioGRID  empirical  20362542  POU5F1   ZNF513   IntAct, BioGRID  empirical  20362542  POU5F1   ZFP42   BioGRID  empirical  17093407  POU5F1   CREB1   IntAct, BioGRID  empirical  20362542  POU5F1   ATF2   IntAct, BioGRID  empirical  20362542  POU5F1   PARP1   IntAct, BioGRID  empirical  20362542  POU5F1   CTBP1   IntAct, BioGRID  empirical  20362542  POU5F1   CTBP2   IntAct, BioGRID  empirical  20362542  20362541  POU5F1   DDB1   IntAct, BioGRID  empirical  20362542  POU5F1   DHX9   IntAct, BioGRID  empirical  20362542  POU5F1   DNMT3A   IntAct, BioGRID  empirical  20362542  POU5F1   NR0B1   IntAct, BioGRID  empirical  17093407  20362541  19528230  POU5F1   PHC1   BioGRID  empirical  20362541  POU5F1   EMD   IntAct, BioGRID  empirical  20362542  POU5F1   ESRRB   BioGRID  empirical  18662995  20362541  POU5F1   ETS2   HPRD  empirical  11689681  POU5F1   EWSR1   HPRD, IntAct, BioGRID  empirical  15917470  17093407  POU5F1   ACIN1   IntAct, BioGRID  empirical  20362542  POU5F1   KDM1A   IntAct, BioGRID  empirical  20362542  20362541  POU5F1   ZBTB43   IntAct, BioGRID  empirical  20362542  POU5F1   MGA   BioGRID  empirical  20362541  POU5F1   RYBP   BioGRID  empirical  20362541  17093407  POU5F1   CABIN1   BioGRID  empirical  20362542  POU5F1   ZNF281   BioGRID  empirical  18757296  POU5F1   FRG1   BioGRID  empirical  20362541  POU5F1   UBN2   IntAct, BioGRID  empirical  20362542  POU5F1   XRCC6   IntAct, BioGRID  empirical  20362542  POU5F1   ASF1A   IntAct, BioGRID  empirical  20362542  POU5F1   CHD5   IntAct, BioGRID  empirical  20362542  POU5F1   FOXD3   HPRD, IntAct  empirical  11891324  POU5F1   SALL3   IntAct, BioGRID  empirical  20362542  POU5F1   RCOR2   IntAct  empirical  20362542  POU5F1   MSH6   IntAct, BioGRID  empirical  20362542  POU5F1   TFCP2L1   BioGRID  empirical  20362541  POU5F1   DNMT3L   IntAct, BioGRID  empirical  20362542  POU5F1   HCFC1   IntAct, BioGRID  empirical  20362542  20362541  POU5F1   HDAC1   IntAct, BioGRID  empirical  20362542  20362541  POU5F1   HDAC2   BioGRID  empirical  20362541  17093407  18454139  POU5F1   HELLS   IntAct, BioGRID  empirical  20362542  20362541  POU5F1   SOX8   HPRD  empirical  16582099  POU5F1   HMGB1   HPRD, BioGRID  empirical  11099378  POU5F1   HMGB2   HPRD, MINT, BioGRID  empirical  11099378  POU5F1   HNRNPAB   IntAct, BioGRID  empirical  20362542  POU5F1   HNRNPL   IntAct, BioGRID  empirical  20362542  POU5F1   HNRNPU   IntAct, BioGRID  empirical  20362542  POU5F1   DNAJA1   IntAct, BioGRID  empirical  20362542  POU5F1   RBPJ   BioGRID  empirical  20362541  POU5F1   AR   HPRD  empirical  11096094  POU5F1   KPNA2   IntAct, BioGRID  empirical  20362542  POU5F1   KPNA3   IntAct, BioGRID  empirical  20362542  POU5F1   LIG3   IntAct, BioGRID  empirical  20362542  POU5F1   MITF   IntAct, BioGRID  empirical  20362542  POU5F1   MNAT1   HPRD, BioGRID  empirical  9368058  POU5F1   MSH2   BioGRID  empirical  20362541  POU5F1   ZFHX3   IntAct, BioGRID  empirical  20362542  POU5F1   NFRKB   IntAct, BioGRID  empirical  20362542  POU5F1   NFYC   IntAct, BioGRID  empirical  20362542  POU5F1   P4HA1   IntAct, BioGRID  empirical  20362542  POU5F1   ZNF219   IntAct, BioGRID  empirical  20362542  20362541  17093407  POU5F1   AMOTL2   IntAct, BioGRID  empirical  20362542  POU5F1   TRIM33   IntAct, BioGRID  empirical  20362542  POU5F1   PKM2   IntAct  empirical  18191611  POU5F1   MBD3   IntAct, BioGRID  empirical  20362542  20362541  18454139  POU5F1   PML   BioGRID  empirical  20362541  POU5F1   BRWD1   IntAct, BioGRID  empirical  20362542  POU5F1   L1TD1   BioGRID  empirical  20362541  POU5F1   POU5F1   IntAct, BioGRID  empirical  20362542  18454139  POU5F1   INO80   IntAct, BioGRID  empirical  20362542  POU5F1   GATAD2A   IntAct, BioGRID  empirical  20362542  20362541  POU5F1   PPP2R1A   IntAct, BioGRID  empirical  20362542  POU5F1   RIF1   BioGRID  empirical  20362541  POU5F1   C12orf35   BioGRID  empirical  20362541  POU5F1   ZCCHC8   BioGRID  empirical  20362541  POU5F1   PSMB6   IntAct  empirical  20362542  POU5F1   C11orf30   BioGRID  empirical  20362541  POU5F1   SALL4   IntAct, BioGRID  empirical  20362542  19060217  20362541  POU5F1   GATAD2B   IntAct, BioGRID  empirical  20362542  20362541  17093407  POU5F1   MTA3   IntAct, BioGRID  empirical  20362542  20362541  POU5F1   ZBTB2   IntAct, BioGRID  empirical  20362542  POU5F1   EP400   BioGRID  empirical  20362541  POU5F1   ZNF462   BioGRID  empirical  20362541  POU5F1   RBBP7   BioGRID  empirical  20362541  18454139  POU5F1   DPF2   BioGRID  empirical  20362541  17093407  POU5F1   RFX2   IntAct, BioGRID  empirical  20362542  POU5F1   RNF2   BioGRID  empirical  20362541  POU5F1   RPA1   IntAct, BioGRID  empirical  20362542  POU5F1   RPA3   IntAct, BioGRID  empirical  20362542  POU5F1   SALL1   IntAct, BioGRID  empirical  20362542  20362541  POU5F1   SLC8A1   IntAct  empirical  17093407  POU5F1   SMARCA4   IntAct, BioGRID  empirical  20362542  20362541  POU5F1   ZBTB10   IntAct, BioGRID  empirical  20362542  POU5F1   SMARCC1   IntAct, BioGRID  empirical  20362542  20362541  POU5F1   SOX2   HPRD, BioGRID  empirical  12923055  20362541  15863505  POU5F1   SOX10   HPRD  empirical  16582099  POU5F1   SOX15   BioGRID  empirical  15863505  POU5F1   SP1   IntAct, BioGRID  empirical  20362542  17093407  POU5F1   SSRP1   IntAct, BioGRID  empirical  20362542  POU5F1   TFE3   IntAct, BioGRID  empirical  20362542  POU5F1   TOP2A   IntAct, BioGRID  empirical  20362542  POU5F1   HIRA   IntAct, BioGRID  empirical  20362542  POU5F1   UBC   BioGRID  empirical  17013377  POU5F1   UBE2I   BioGRID  empirical  17097055  POU5F1   SUMO1   BioGRID  empirical  17525163  POU5F1   UBP1   BioGRID  empirical  20362541  POU5F1   XRCC1   IntAct, BioGRID  empirical  20362542  POU5F1   XRCC5   IntAct, BioGRID  empirical  20362542  POU5F1   ZIC2   IntAct, BioGRID  empirical  20362542  POU5F1   ZNF143   BioGRID  empirical  20362541  18687992  POU5F1   ZNF217   IntAct, BioGRID  empirical  20362542  POU5F1   CAD   IntAct, BioGRID  empirical  20362542  POU5F1   TFEB   IntAct, BioGRID  empirical  20362542  POU5F1   NANOG   IntAct, BioGRID  empirical  17093407  18454139  POU5F1   PHF17   IntAct, BioGRID  empirical  20362542  POU5F1   CUBN   IntAct, BioGRID  empirical  20362542  POU5F1   SMC1A   BioGRID  empirical  20362541  POU5F1   TRRAP   BioGRID  empirical  20362541  POU5F1   CUL4B   IntAct, BioGRID  empirical  20362542  POU5F1   TTF2   IntAct, BioGRID  empirical  20362542  POU5F1   SMARCA5   IntAct, BioGRID  empirical  20362542  POU5F1   OGT   IntAct, BioGRID  empirical  20362542  20362541  POU5F1   ACTL6A   IntAct, BioGRID  empirical  20362542  POU5F1   TRIM24   IntAct, BioGRID  empirical  20362542  POU5F1   ASH2L   IntAct  empirical  21477851  POU5F1   MTA1   IntAct, BioGRID  empirical  20362542  20362541  18454139  POU5F1   MTA2   IntAct, BioGRID  empirical  20362542  20362541  18454139  POU5F1   KLF4   IntAct, BioGRID  empirical  20362542  POU5F1   MATR3   IntAct, BioGRID  empirical  20362542  POU5F1   CDK1   BioGRID  empirical  17093407  POU5F1   SETDB1   BioGRID  empirical  19884257

View all

KEGG Network: None available   None available.

Biocarta: None available   None available.

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: 1   HIF-2-alpha transcription factor network

Gene Ontology: 35   Sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 Endodermal cell fate specification GO:0001714 Blastocyst development GO:0001824 BMP signaling pathway involved in heart induction GO:0003130 DNA binding GO:0003677 Sequence-specific DNA binding transcription factor activity GO:0003700 Protein binding GO:0005515 Nucleus GO:0005634 Nucleoplasm GO:0005654 Transcription factor complex GO:0005667 Cytoplasm GO:0005737 Cytosol GO:0005829 Transcription, DNA-dependent GO:0006351 Regulation of transcription, DNA-dependent GO:0006355 Transcription from RNA polymerase II promoter GO:0006366 Multicellular organismal development GO:0007275 Transcription factor binding GO:0008134 Response to wounding GO:0009611 Anatomical structure morphogenesis GO:0009653 Regulation of asymmetric cell division GO:0009786 Regulation of gene expression GO:0010468 Ubiquitin protein ligase binding GO:0031625 Somatic stem cell maintenance GO:0035019 MiRNA binding GO:0035198 Positive regulation of catenin import into nucleus GO:0035413 MRNA transcription from RNA polymerase II promoter GO:0042789 Sequence-specific DNA binding GO:0043565 Transcription regulatory region DNA binding GO:0044212 Positive regulation of transcription from RNA polymerase II promoter GO:0045944 Positive regulation of SMAD protein import into nucleus GO:0060391 Cell fate commitment involved in formation of primary germ layers GO:0060795 Cardiac cell fate determination GO:0060913 Negative regulation of gene silencing by miRNA GO:0060965 Regulation of heart induction by regulation of canonical Wnt receptor signaling pathway GO:0090081 Regulation of methylation-dependent chromatin silencing GO:0090308

	KEGG Network: None available
	Biocarta: None available
	Reactome: None available
	NCI-Nature Pathway Interaction Database: 1 HIF-2-alpha transcription factor network
	Gene Ontology: 35 Sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 Endodermal cell fate specification GO:0001714 Blastocyst development GO:0001824 BMP signaling pathway involved in heart induction GO:0003130 DNA binding GO:0003677 Sequence-specific DNA binding transcription factor activity GO:0003700 Protein binding GO:0005515 Nucleus GO:0005634 Nucleoplasm GO:0005654 Transcription factor complex GO:0005667 Cytoplasm GO:0005737 Cytosol GO:0005829 Transcription, DNA-dependent GO:0006351 Regulation of transcription, DNA-dependent GO:0006355 Transcription from RNA polymerase II promoter GO:0006366 Multicellular organismal development GO:0007275 Transcription factor binding GO:0008134 Response to wounding GO:0009611 Anatomical structure morphogenesis GO:0009653 Regulation of asymmetric cell division GO:0009786 Regulation of gene expression GO:0010468 Ubiquitin protein ligase binding GO:0031625 Somatic stem cell maintenance GO:0035019 MiRNA binding GO:0035198 Positive regulation of catenin import into nucleus GO:0035413 MRNA transcription from RNA polymerase II promoter GO:0042789 Sequence-specific DNA binding GO:0043565 Transcription regulatory region DNA binding GO:0044212 Positive regulation of transcription from RNA polymerase II promoter GO:0045944 Positive regulation of SMAD protein import into nucleus GO:0060391 Cell fate commitment involved in formation of primary germ layers GO:0060795 Cardiac cell fate determination GO:0060913 Negative regulation of gene silencing by miRNA GO:0060965 Regulation of heart induction by regulation of canonical Wnt receptor signaling pathway GO:0090081 Regulation of methylation-dependent chromatin silencing GO:0090308

Type 1 Diabetes Publications: 5

• Oct4 is expressed in Nestin-positive cells as a marker for pancreatic endocrine progenitor.
  Wang H, Wang S, Hu J, Kong Y, Chen S, Li L, Li L
  Histochem Cell Biol. 2009
  PubMed ID: 19224238
   
  
• Evidence for the presence of stem cell-like progenitor cells in human adult pancreas.
  Zhao M, Amiel SA, Christie MR, Muiesan P, Srinivasan P, Littlejohn W, Rela M, Arno M, Heaton N, Huang GC
  J Endocrinol. 2007
  PubMed ID: 18000303
   
  
• Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer.
  Katoh Y, Katoh M
  Int J Oncol. 2007
  PubMed ID: 17273778
   
  
• Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro.
  Moriscot C, de Fraipont F, Richard MJ, Marchand M, Savatier P, Bosco D, Favrot M, Benhamou PY
  Stem Cells. 2005
  PubMed ID: 15790780
   
  
• Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues.
  Takeda J, Seino S, Bell GI
  Nucleic Acids Res. 1992
  PubMed ID: 1408763
   
  

Publications: 636

• Pluripotency factors in embryonic stem cells regulate differentiation into germ layers.
  Thomson M, Liu SJ, Zou LN, Smith Z, Meissner A, Ramanathan S
  Cell. 2011
  PubMed ID: 21663792
   
  
• microRNA-145 suppresses lung adenocarcinoma-initiating cell proliferation by targeting OCT4.
  Yin R, Zhang S, Wu Y, Fan X, Jiang F, Zhang Z, Feng D, Guo X, Xu L
  Oncol Rep. 2011
  PubMed ID: 21479367
   
  
• Clinical implications of stem cell gene Oct-4 expression in breast cancer.
  Liu CG, Lu Y, Wang BB, Zhang YJ, Zhang RS, Lu Y, Chen B, Xu H, Jin F, Lu P
  Ann Surg. 2011
  PubMed ID: 21394007
   
  
• OCT4B1, a novel spliced variant of OCT4, is highly expressed in gastric cancer and acts as an antiapoptotic factor.
  Asadi MH, Mowla SJ, Fathi F, Aleyasin A, Asadzadeh J, Atlasi Y
  Int J Cancer. 2011
  PubMed ID: 20824712
   
  
• Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation.
  Manuylov NL, Zhou B, Ma Q, Fox SC, Pu WT, Tevosian SG
  Dev Biol. 2011
  PubMed ID: 21385577
   
  
• Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells.
  Gill ME, Hu YC, Lin Y, Page DC
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21504946
   
  
• Conserved, developmentally regulated mechanism couples chromosomal looping and heterochromatin barrier activity at the homeobox gene A locus.
  Kim YJ, Cecchini KR, Kim TH
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21502535
   
  
• A case-control study on the rs3130932 single nucleotide polymorphism in the OCT4B translation initiation codon in association with cancer state.
  Katafigiotis S, Papamichos SI, Katopodi R, Papazisis K, Mylonaki E, Repana D, Kotoula V, Karavidopoulou Y, Agorastos T, Tarlatzis BC, Lambropoulos AF
  Eur J Cancer Prev. 2011
  PubMed ID: 21301344
   
  
• Pluripotency regulators in human mesenchymal stem cells: expression of NANOG but not of OCT-4 and SOX-2.
  Pierantozzi E, Gava B, Manini I, Roviello F, Marotta G, Chiavarelli M, Sorrentino V
  Stem Cells Dev. 2011
  PubMed ID: 20879854
   
  
• Geminin escapes degradation in G1 of mouse pluripotent cells and mediates the expression of Oct4, Sox2, and Nanog.
  Yang VS, Carter SA, Hyland SJ, Tachibana-Konwalski K, Laskey RA, Gonzalez MA
  Curr Biol. 2011
  PubMed ID: 21497086
   
  
• Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network.
  Ang YS, Tsai SY, Lee DF, Monk J, Su J, Ratnakumar K, Ding J, Ge Y, Darr H, Chang B, Wang J, Rendl M, Bernstein E, Schaniel C, Lemischka IR
  Cell. 2011
  PubMed ID: 21477851
   
  
• Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency.
  Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, Zhang Y, Yang W, Gruber PJ, Epstein JA, Morrisey EE
  Cell Stem Cell. 2011
  PubMed ID: 21474102
   
  
• [miR-145 inhibits lung adenocarcinoma stem cells proliferation by targeting OCT4 gene].
  Zhang S, Wu Y, Feng D, Zhang Z, Jiang F, Yin R, Xu L
  Zhongguo Fei Ai Za Zhi. 2011
  PubMed ID: 21496429
   
  
• A rapid and scalable system for studying gene function in mice using conditional RNA interference.
  Premsrirut PK, Dow LE, Kim SY, Camiolo M, Malone CD, Miething C, Scuoppo C, Zuber J, Dickins RA, Kogan SC, Shroyer KR, Sordella R, Hannon GJ, Lowe SW
  Cell. 2011
  PubMed ID: 21458673
   
  
• Expression pattern of Oct-4, Sox2, and c-Myc in the primary culture of human dental pulp derived cells.
  Liu L, Wei X, Ling J, Wu L, Xiao Y
  J Endod. 2011
  PubMed ID: 21419292
   
  
• Dual roles of Oct4 in the maintenance of mouse P19 embryonal carcinoma cells: as negative regulator of Wnt/β-catenin signaling and competence provider for Brachyury induction.
  Marikawa Y, Tamashiro DA, Fujita TC, Alarcon VB
  Stem Cells Dev. 2011
  PubMed ID: 21083502
   
  
• Histone methylation is a critical regulator of the abnormal expression of POU5F1 and RASSF1A in testis cancer cell lines.
  Lambrot R, Kimmins S
  Int J Androl. 2011
  PubMed ID: 20497257
   
  
• Oct-4B isoform is differentially expressed in breast cancer cells: hypermethylation of regulatory elements of Oct-4A suggests an alternative promoter and transcriptional start site for Oct-4B transcription.
  Wang Y, Meng L, Hu H, Zhang Y, Zhao C, Li Q, Shi F, Wang X, Lin A
  Biosci Rep. 2011
  PubMed ID: 20433421
   
  
• Nuclear orphan receptor TLX induces Oct-3/4 for the survival and maintenance of adult hippocampal progenitors upon hypoxia.
  Chavali PL, Saini RK, Matsumoto Y, Ågren H, Funa K
  J Biol Chem. 2011
  PubMed ID: 21135096
   
  
• Activation of the aryl hydrocarbon receptor AhR Promotes retinoic acid-induced differentiation of myeloblastic leukemia cells by restricting expression of the stem cell transcription factor Oct4.
  Bunaciu RP, Yen A
  Cancer Res. 2011
  PubMed ID: 21262915
   
  
• Small RNA-mediated regulation of iPS cell generation.
  Li Z, Yang CS, Nakashima K, Rana TM
  EMBO J. 2011
  PubMed ID: 21285944
   
  
• Brief report: combined chemical treatment enables Oct4-induced reprogramming from mouse embryonic fibroblasts.
  Yuan X, Wan H, Zhao X, Zhu S, Zhou Q, Ding S
  Stem Cells. 2011
  PubMed ID: 21425417
   
  
• MyoD gene suppression by Oct4 is required for reprogramming in myoblasts to produce induced pluripotent stem cells.
  Watanabe S, Hirai H, Asakura Y, Tastad C, Verma M, Keller C, Dutton JR, Asakura A
  Stem Cells. 2011
  PubMed ID: 21425413
   
  
• New candidate gene POU5F1 associated with premature ovarian failure in Chinese patients.
  Wang J, Wang B, Song J, Suo P, Ni F, Chen B, Ma X, Cao Y
  Reprod Biomed Online. 2011
  PubMed ID: 21273125
   
  
• Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor.
  Li L, Kwon HJ, Harada H, Ohshima H, Cho SW, Jung HS
  Gene Expr Patterns. 2011
  PubMed ID: 21073982
   
  
• Transient expression of OCT4 is sufficient to allow human keratinocytes to change their differentiation pathway.
  Racila D, Winter M, Said M, Tomanek-Chalkley A, Wiechert S, Eckert RL, Bickenbach JR
  Gene Ther. 2011
  PubMed ID: 20981110
   
  
• Oct4 regulates the miR-302 cluster in P19 mouse embryonic carcinoma cells.
  Liu H, Deng S, Zhao Z, Zhang H, Xiao J, Song W, Gao F, Guan Y
  Mol Biol Rep. 2011
  PubMed ID: 20857206
   
  
• Transcriptional regulation of oct4 in human bone marrow mesenchymal stem cells.
  Wei X, Shen CY
  Stem Cells Dev. 2011
  PubMed ID: 20594032
   
  
• TIF1β association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis.
  Herzog M, Wendling O, Guillou F, Chambon P, Mark M, Losson R, Cammas F
  Dev Biol. 2011
  PubMed ID: 21163256
   
  
• β-Catenin Enhances Oct-4 Activity and Reinforces Pluripotency through a TCF-Independent Mechanism.
  Kelly KF, Ng DY, Jayakumaran G, Wood GA, Koide H, Doble BW
  Cell Stem Cell. 2011
  PubMed ID: 21295277
   
  
• Oct4 kinetics predict cell lineage patterning in the early mammalian embryo.
  Plachta N, Bollenbach T, Pease S, Fraser SE, Pantazis P
  Nat Cell Biol. 2011
  PubMed ID: 21258368
   
  
• Pluripotency factors regulate definitive endoderm specification through eomesodermin.
  Teo AK, Arnold SJ, Trotter MW, Brown S, Ang LT, Chng Z, Robertson EJ, Dunn NR, Vallier L
  Genes Dev. 2011
  PubMed ID: 21245162
   
  
• SAF-A has a role in transcriptional regulation of Oct4 in ES cells through promoter binding.
  Vizlin-Hodzic D, Johansson H, Ryme J, Simonsson T, Simonsson S
  Cell Reprogram. 2011
  PubMed ID: 21235343
   
  
• A regulatory circuitry comprised of miR-302 and the transcription factors OCT4 and NR2F2 regulates human embryonic stem cell differentiation.
  Rosa A, Brivanlou AH
  EMBO J. 2011
  PubMed ID: 21151097
   
  
• Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.
  Kim B, Kim Y, Sakuma R, Hui CC, Rüther U, Jorgensen JS
  Dev Biol. 2011
  PubMed ID: 20969841
   
  
• Mitotic arrest in teratoma susceptible fetal male germ cells.
  Western PS, Ralli RA, Wakeling SI, Lo C, van den Bergen JA, Miles DC, Sinclair AH
  PLoS One. 2011
  PubMed ID: 21674058
   
  
• Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1.
  Warr N, Bogani D, Siggers P, Brixey R, Tateossian H, Dopplapudi A, Wells S, Cheeseman M, Xia Y, Ostrer H, Greenfield A
  PLoS One. 2011
  PubMed ID: 21559298
   
  
• Correct patterning of the primitive streak requires the anterior visceral endoderm.
  Stuckey DW, Di Gregorio A, Clements M, Rodriguez TA
  PLoS One. 2011
  PubMed ID: 21445260
   
  
• Direct reprogramming of fibroblasts into epiblast stem cells.
  Han DW, Greber B, Wu G, Tapia N, Araúzo-Bravo MJ, Ko K, Bernemann C, Stehling M, Schöler HR
  Nat Cell Biol. 2011
  PubMed ID: 21131959
   
  
• Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background.
  Cook MS, Munger SC, Nadeau JH, Capel B
  Development. 2011
  PubMed ID: 21115610
   
  
• Development of thyroid gland and ultimobranchial body cyst is independent of p63.
  Ozaki T, Nagashima K, Kusakabe T, Kakudo K, Kimura S
  Lab Invest. 2011
  PubMed ID: 20697379
   
  
• Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency.
  Tee WW, Pardo M, Theunissen TW, Yu L, Choudhary JS, Hajkova P, Surani MA
  Genes Dev. 2010
  PubMed ID: 21159818
   
  
• Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation.
  Chiou SH, Wang ML, Chou YT, Chen CJ, Hong CF, Hsieh WJ, Chang HT, Chen YS, Lin TW, Hsu HS, Wu CW
  Cancer Res. 2010
  PubMed ID: 21159654
   
  
• Oct4 expression in immature teratoma of the ovary: relevance to histologic grade and degree of differentiation.
  Abiko K, Mandai M, Hamanishi J, Matsumura N, Baba T, Horiuchi A, Mikami Y, Yoshioka S, Wakasa T, Shiozawa T, Konishi I
  Am J Surg Pathol. 2010
  PubMed ID: 21107090
   
  
• Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA.
  Kelly VR, Xu B, Kuick R, Koenig RJ, Hammer GD
  Mol Endocrinol. 2010
  PubMed ID: 20943815
   
  
• Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3.
  Duan H, Wang J
  J Pharmacol Exp Ther. 2010
  PubMed ID: 20858707
   
  
• The expression of stem cell-related indicators as a prognostic factor in human lung adenocarcinoma.
  Zhang XY, Dong QG, Huang JS, Huang AM, Shi CL, Jin B, Sha HF, Feng JX, Geng Q, Zhou J, Xu HL, Han BH
  J Surg Oncol. 2010
  PubMed ID: 20818602
   
  
• Newer insights into premeiotic development of germ cells in adult human testis using Oct-4 as a stem cell marker.
  Bhartiya D, Kasiviswanathan S, Unni SK, Pethe P, Dhabalia JV, Patwardhan S, Tongaonkar HB
  J Histochem Cytochem. 2010
  PubMed ID: 20805580
   
  
• A male-specific role for p38 mitogen-activated protein kinase in germ cell sex differentiation in mice.
  Ewen K, Jackson A, Wilhelm D, Koopman P
  Biol Reprod. 2010
  PubMed ID: 20739663
   
  
• Ascorbic acid induces in vitro proliferation of human subcutaneous adipose tissue derived mesenchymal stem cells with upregulation of embryonic stem cell pluripotency markers Oct4 and SOX 2.
  Potdar PD, D'Souza SB
  Hum Cell. 2010
  PubMed ID: 21166886
   
  
• Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination.
  Johansson H, Simonsson S
  Aging (Albany NY). 2010
  PubMed ID: 21076177
   
  
• Human corneal basal epithelial cells express an embryonic stem cell marker OCT4.
  Zhou SY, Zhang C, Baradaran E, Chuck RS
  Curr Eye Res. 2010
  PubMed ID: 20958186
   
  
• Oct1 regulates trophoblast development during early mouse embryogenesis.
  Sebastiano V, Dalvai M, Gentile L, Schubart K, Sutter J, Wu GM, Tapia N, Esch D, Ju JY, Hübner K, Bravo MJ, Schöler HR, Cavaleri F, Matthias P
  Development. 2010
  PubMed ID: 20876643
   
  
• Atypical expression and distribution of embryonic stem cell marker, OCT4, in human lung adenocarcinoma.
  Karoubi G, Cortes-Dericks L, Gugger M, Galetta D, Spaggiari L, Schmid RA
  J Surg Oncol. 2010
  PubMed ID: 20721963
   
  
• Comparative study of stemness characteristics of mesenchymal cells from bone marrow of children and adults.
  Choumerianou DM, Martimianaki G, Stiakaki E, Kalmanti L, Kalmanti M, Dimitriou H
  Cytotherapy. 2010
  PubMed ID: 20662612
   
  
• OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome.
  Bianco B, Oliveira KC, Guedes AD, Barbosa CP, Lipay MV, Verreschi IT
  Fertil Steril. 2010
  PubMed ID: 20347080
   
  
• OCT4 and downstream factors are expressed in human somatic urogenital epithelia and in culture of epididymal spheres.
  Kristensen DM, Nielsen JE, Kalisz M, Dalgaard MD, Audouze K, Larsen ME, Jacobsen GK, Horn T, Brunak S, Skakkebaek NE, Leffers H
  Mol Hum Reprod. 2010
  PubMed ID: 20123703
   
  
• New testicular mechanisms involved in the prevention of fetal meiotic initiation in mice.
  Guerquin MJ, Duquenne C, Lahaye JB, Tourpin S, Habert R, Livera G
  Dev Biol. 2010
  PubMed ID: 20707993
   
  
• Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/β-catenin signalling.
  Abu-Remaileh M, Gerson A, Farago M, Nathan G, Alkalay I, Zins Rousso S, Gur M, Fainsod A, Bergman Y
  EMBO J. 2010
  PubMed ID: 20736927
   
  
• Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.
  Mesnard D, Constam DB
  J Cell Biol. 2010
  PubMed ID: 20876279
   
  
• The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells.
  Fernandez-Diaz LC, Laurent A, Girasoli S, Turco M, Longobardi E, Iotti G, Jenkins NA, Fiorenza MT, Copeland NG, Blasi F
  Development. 2010
  PubMed ID: 20826531
   
  
• O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.
  Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC
  Dev Biol. 2010
  PubMed ID: 20637190
   
  
• Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.
  Ucisik-Akkaya E, Davis CF, Do TN, Morrison BA, Stemmer SM, Amadio WJ, Tevfik Dorak M
  Mol Hum Reprod. 2010
  PubMed ID: 20587610
   
  
• OCT3/4 regulates transcription of histone deacetylase 4 (Hdac4) in mouse embryonic stem cells.
  Addis RC, Prasad MK, Yochem RL, Zhan X, Sheets TP, Axelman J, Patterson ES, Shamblott MJ
  J Cell Biochem. 2010
  PubMed ID: 20506506
   
  
• Prognostic significance of OCT4 expression in adenocarcinoma of the lung.
  Zhang X, Han B, Huang J, Zheng B, Geng Q, Aziz F, Dong Q
  Jpn J Clin Oncol. 2010
  PubMed ID: 20462980
   
  
• Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells.
  Trubiani O, Zalzal SF, Paganelli R, Marchisio M, Giancola R, Pizzicannella J, Bühring HJ, Piattelli M, Caputi S, Nanci A
  J Cell Physiol. 2010
  PubMed ID: 20458727
   
  
• Mediator and cohesin connect gene expression and chromatin architecture.
  Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J, Young RA
  Nature. 2010
  PubMed ID: 20720539
   
  
• Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors.
  Zhu R, Heaney J, Nadeau JH, Ali S, Matin A
  Cancer Res. 2010
  PubMed ID: 20736371
   
  
• FGF9 suppresses meiosis and promotes male germ cell fate in mice.
  Bowles J, Feng CW, Spiller C, Davidson TL, Jackson A, Koopman P
  Dev Cell. 2010
  PubMed ID: 20833365
   
  
• Single-molecule analysis reveals changes in the DNA replication program for the POU5F1 locus upon human embryonic stem cell differentiation.
  Schultz SS, Desbordes SC, Du Z, Kosiyatrakul S, Lipchina I, Studer L, Schildkraut CL
  Mol Cell Biol. 2010
  PubMed ID: 20647538
   
  
• Dynamic methylation and expression of Oct4 in early neural stem cells.
  Lee SH, Jeyapalan JN, Appleby V, Mohamed Noor DA, Sottile V, Scotting PJ
  J Anat. 2010
  PubMed ID: 20646110
   
  
• Rapid and efficient reprogramming of human amnion-derived cells into pluripotency by three factors OCT4/SOX2/NANOG.
  Zhao HX, Li Y, Jin HF, Xie L, Liu C, Jiang F, Luo YN, Yin GW, Li Y, Wang J, Li LS, Yao YQ, Wang XH
  Differentiation. 2010
  PubMed ID: 20510497
   
  
• Murine trophoblast cells induce NK cell interferon-gamma production through KLRK1.
  Carayannopoulos LN, Barks JL, Yokoyama WM, Riley JK
  Biol Reprod. 2010
  PubMed ID: 20484740
   
  
• An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo.
  Spruce T, Pernaute B, Di-Gregorio A, Cobb BS, Merkenschlager M, Manzanares M, Rodriguez TA
  Dev Cell. 2010
  PubMed ID: 20708584
   
  
• [Significance of Oct-4's expression in thyroid neoplasm].
  Wang H, Wang J
  Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010
  PubMed ID: 20942235
   
  
• Enrichment of short interspersed transposable elements to embryonic stem cell-specific hypomethylated gene regions.
  Muramoto H, Yagi S, Hirabayashi K, Sato S, Ohgane J, Tanaka S, Shiota K
  Genes Cells. 2010
  PubMed ID: 20629982
   
  
• Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment.
  Alder O, Lavial F, Helness A, Brookes E, Pinho S, Chandrashekran A, Arnaud P, Pombo A, O'Neill L, Azuara V
  Development. 2010
  PubMed ID: 20573702
   
  
• Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo.
  Morsut L, Yan KP, Enzo E, Aragona M, Soligo SM, Wendling O, Mark M, Khetchoumian K, Bressan G, Chambon P, Dupont S, Losson R, Piccolo S
  Development. 2010
  PubMed ID: 20573697
   
  
• Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation.
  Payne CJ, Gallagher SJ, Foreman O, Dannenberg JH, Depinho RA, Braun RE
  Stem Cells. 2010
  PubMed ID: 20572009
   
  
• Phenotypic annotation of the mouse X chromosome.
  Cox BJ, Vollmer M, Tamplin O, Lu M, Biechele S, Gertsenstein M, van Campenhout C, Floss T, Kühn R, Wurst W, Lickert H, Rossant J
  Genome Res. 2010
  PubMed ID: 20548051
   
  
• A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4.
  Smith JA, Ndoye AM, Geary K, Lisanti MP, Igoucheva O, Daniel R
  Aging Cell. 2010
  PubMed ID: 20477760
   
  
• Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism.
  Messerschmidt DM, Kemler R
  Dev Biol. 2010
  PubMed ID: 20435031
   
  
• Induction of pluripotent stem cells from adult somatic cells by protein-based reprogramming without genetic manipulation.
  Cho HJ, Lee CS, Kwon YW, Paek JS, Lee SH, Hur J, Lee EJ, Roh TY, Chu IS, Leem SH, Kim Y, Kang HJ, Park YB, Kim HS
  Blood. 2010
  PubMed ID: 20439621
   
  
• HSPC117 deficiency in cloned embryos causes placental abnormality and fetal death.
  Wang Y, Hai T, Liu Z, Zhou S, Lv Z, Ding C, Liu L, Niu Y, Zhao X, Tong M, Wang L, Jouneau A, Zhang X, Ji W, Zhou Q
  Biochem Biophys Res Commun. 2010
  PubMed ID: 20510672
   
  
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
  Mol Med. 2010
  PubMed ID: 20379614
   
  
• Oct4 and Nanog expression is associated with early stages of pancreatic carcinogenesis.
  Wen J, Park JY, Park KH, Chung HW, Bang S, Park SW, Song SY
  Pancreas. 2010
  PubMed ID: 20173672
   
  
• TIF1beta regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner.
  Seki Y, Kurisaki A, Watanabe-Susaki K, Nakajima Y, Nakanishi M, Arai Y, Shiota K, Sugino H, Asashima M
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20508149
   
  
• Rapid estrogen signalling in mouse primordial germ cells.
  La Sala G, Farini D, De Felici M
  Exp Cell Res. 2010
  PubMed ID: 20380832
   
  
• Generation of human-induced pluripotent stem cells from gut mesentery-derived cells by ectopic expression of OCT4/SOX2/NANOG.
  Li Y, Zhao H, Lan F, Lee A, Chen L, Lin C, Yao Y, Li L
  Cell Reprogram. 2010
  PubMed ID: 20698766
   
  
• Lin9, a subunit of the mammalian DREAM complex, is essential for embryonic development, for survival of adult mice, and for tumor suppression.
  Reichert N, Wurster S, Ulrich T, Schmitt K, Hauser S, Probst L, Götz R, Ceteci F, Moll R, Rapp U, Gaubatz S
  Mol Cell Biol. 2010
  PubMed ID: 20404087
   
  
• Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis.
  Chu J, Shen MM
  Dev Biol. 2010
  PubMed ID: 20346354
   
  
• Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species.
  Xie D, Chen CC, Ptaszek LM, Xiao S, Cao X, Fang F, Ng HH, Lewin HA, Cowan C, Zhong S
  Genome Res. 2010
  PubMed ID: 20219939
   
  
• Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines.
  Marques DS, Sandrini JZ, Boyle RT, Marins LF, Trindade GS
  Leuk Res. 2010
  PubMed ID: 19969351
   
  
• Natural immunity to pluripotency antigen OCT4 in humans.
  Dhodapkar KM, Feldman D, Matthews P, Radfar S, Pickering R, Turkula S, Zebroski H, Dhodapkar MV
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20404147
   
  
• Concise review: isoforms of OCT4 contribute to the confusing diversity in stem cell biology.
  Wang X, Dai J
  Stem Cells. 2010
  PubMed ID: 20333750
   
  
• Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
  Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
  Dev Cell. 2010
  PubMed ID: 20412781
   
  
• Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development.
  Naillat F, Prunskaite-Hyyryläinen R, Pietilä I, Sormunen R, Jokela T, Shan J, Vainio SJ
  Hum Mol Genet. 2010
  PubMed ID: 20106871
   
  
• Mapping of the minimal internal ribosome entry site element in the human embryonic stem cell gene OCT4B mRNA.
  Zhang W, Wang X, Xiao Z, Liu W, Chen B, Dai J
  Biochem Biophys Res Commun. 2010
  PubMed ID: 20230781
   
  
• Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer.
  Peng S, Maihle NJ, Huang Y
  Oncogene. 2010
  PubMed ID: 20101213
   
  
• An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.
  Pardo M, Lang B, Yu L, Prosser H, Bradley A, Babu MM, Choudhary J
  Cell Stem Cell. 2010
  PubMed ID: 20362542
   
  
• An Oct4-centered protein interaction network in embryonic stem cells.
  van den Berg DL, Snoek T, Mullin NP, Yates A, Bezstarosti K, Demmers J, Chambers I, Poot RA
  Cell Stem Cell. 2010
  PubMed ID: 20362541
   
  
• [The dual role of OCT4]
  Stefanovic S, Pucéat M
  Med Sci (Paris). 2010
  PubMed ID: 20412747
   
  
• Human embryonic stem cells from aneuploid blastocysts identified by pre-implantation genetic screening.
  Narwani K, Biancotti JC, Golan-Lev T, Buehler N, Hill D, Shifman S, Benvenisty N, Lavon N
  In Vitro Cell Dev Biol Anim. 2010
  PubMed ID: 20224970
   
  
• A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells.
  Raya A, Rodríguez-Pizà I, Navarro S, Richaud-Patin Y, Guenechea G, Sánchez-Danés A, Consiglio A, Bueren J, Izpisúa Belmonte JC
  Nat Protoc. 2010
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• Function of EWS-POU5F1 in sarcomagenesis and tumor cell maintenance.
  Fujino T, Nomura K, Ishikawa Y, Makino H, Umezawa A, Aburatani H, Nagasaki K, Nakamura T
  Am J Pathol. 2010
  PubMed ID: 20203285
   
  
• Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension.
  Firth AL, Yao W, Remillard CV, Ogawa A, Yuan JX
  Am J Physiol Lung Cell Mol Physiol. 2010
  PubMed ID: 20139178
   
  
• Cloning of complementary DNAs encoding structurally related homeoproteins from preimplantation mouse embryos: their involvement in the differentiation of embryonic stem cells.
  Saito K, Abe H, Nakazawa M, Irokawa E, Watanabe M, Hosoi Y, Soma M, Kasuga K, Kojima I, Kobayashi M
  Biol Reprod. 2010
  PubMed ID: 20018908
   
  
• Protogenin defines a transition stage during embryonic neurogenesis and prevents precocious neuronal differentiation.
  Wong YH, Lu AC, Wang YC, Cheng HC, Chang C, Chen PH, Yu JY, Fann MJ
  J Neurosci. 2010
  PubMed ID: 20335479
   
  
• Side population increase after simulated transient ischemia in human dental pulp cell.
  Wang J, Wei X, Ling J, Huang Y, Gong Q
  J Endod. 2010
  PubMed ID: 20171362
   
  
• Transcriptional regulation of the Oct4 gene, a master gene for pluripotency.
  Kellner S, Kikyo N
  Histol Histopathol. 2010
  PubMed ID: 20054811
   
  
• Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner.
  Liao B, Jin Y
  Cell Res. 2010
  PubMed ID: 19997087
   
  
• Oct-4 controls cell-cycle progression of embryonic stem cells.
  Lee J, Go Y, Kang I, Han YM, Kim J
  Biochem J. 2010
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• Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells.
  Qiu C, Ma Y, Wang J, Peng S, Huang Y
  Nucleic Acids Res. 2010
  PubMed ID: 19966271
   
  
• Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cells.
  Teng Y, Wang X, Wang Y, Ma D
  Biochem Biophys Res Commun. 2010
  PubMed ID: 20074550
   
  
• The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells.
  Heng JC, Feng B, Han J, Jiang J, Kraus P, Ng JH, Orlov YL, Huss M, Yang L, Lufkin T, Lim B, Ng HH
  Cell Stem Cell. 2010
  PubMed ID: 20096661
   
  
• Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.
  Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K
  Genes Dev. 2010
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• Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach.
  Mattison J, Kool J, Uren AG, de Ridder J, Wessels L, Jonkers J, Bignell GR, Butler A, Rust AG, Brosch M, Wilson CH, van der Weyden L, Largaespada DA, Stratton MR, Futreal PA, van Lohuizen M, Berns A, Collier LS, Hubbard T, Adams DJ
  Cancer Res. 2010
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• Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2.
  Ralston A, Cox BJ, Nishioka N, Sasaki H, Chea E, Rugg-Gunn P, Guo G, Robson P, Draper JS, Rossant J
  Development. 2010
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• Conserved long noncoding RNAs transcriptionally regulated by Oct4 and Nanog modulate pluripotency in mouse embryonic stem cells.
  Sheik Mohamed J, Gaughwin PM, Lim B, Robson P, Lipovich L
  RNA. 2010
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• Comparison of extraembryonic expression of Eomes and Cdx2 in pregastrulation chick and mouse embryo unveils regulatory changes along evolution.
  Pernaute B, Cañon S, Crespo M, Fernandez-Tresguerres B, Rayon T, Manzanares M
  Dev Dyn. 2010
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• Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development.
  Polanco JC, Wilhelm D, Davidson TL, Knight D, Koopman P
  Hum Mol Genet. 2010
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• Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3.
  Yamaji M, Tanaka T, Shigeta M, Chuma S, Saga Y, Saitou M
  Reproduction. 2010
  PubMed ID: 19861488
   
  
• Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation.
  Li L, Sun L, Gao F, Jiang J, Yang Y, Li C, Gu J, Wei Z, Yang A, Lu R, Ma Y, Tang F, Kwon SW, Zhao Y, Li J, Jin Y
  Proc Natl Acad Sci U S A. 2010
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• Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets.
  Ideguchi M, Palmer TD, Recht LD, Weimann JM
  J Neurosci. 2010
  PubMed ID: 20089898
   
  
• EWS-Oct-4B, an alternative EWS-Oct-4 fusion gene, is a potent oncogene linked to human epithelial tumours.
  Kim S, Lim B, Kim J
  Br J Cancer. 2010
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• Enhancing somatic nuclear reprogramming by Oct4 gain-of-function in cloned mouse embryos.
  Pfeiffer MJ, Balbach ST, Esteves TC, Crosetto N, Boiani M
  Int J Dev Biol. 2010
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• Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma.
  Ge N, Lin HX, Xiao XS, Guo L, Xu HM, Wang X, Jin T, Cai XY, Liang Y, Hu WH, Kang T
  J Transl Med. 2010
  PubMed ID: 20937145
   
  
• EMG1 is essential for mouse pre-implantation embryo development.
  Wu X, Sandhu S, Patel N, Triggs-Raine B, Ding H
  BMC Dev Biol. 2010
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• Epigenetic mechanisms regulate stem cell expressed genes Pou5f1 and Gfra1 in a male germ cell line.
  Godmann M, May E, Kimmins S
  PLoS One. 2010
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• Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient.
  Ahn JY, Lee JT
  BMC Dev Biol. 2010
  PubMed ID: 20727175
   
  
• A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells.
  Yang J, Gao C, Chai L, Ma Y
  PLoS One. 2010
  PubMed ID: 20505821
   
  
• A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells.
  Jung M, Peterson H, Chavez L, Kahlem P, Lehrach H, Vilo J, Adjaye J
  PLoS One. 2010
  PubMed ID: 20505756
   
  
• Brg1 is required for Cdx2-mediated repression of Oct4 expression in mouse blastocysts.
  Wang K, Sengupta S, Magnani L, Wilson CA, Henry RW, Knott JG
  PLoS One. 2010
  PubMed ID: 20485553
   
  
• Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo.
  Ahmed K, Dehghani H, Rugg-Gunn P, Fussner E, Rossant J, Bazett-Jones DP
  PLoS One. 2010
  PubMed ID: 20479880
   
  
• OCT-4 expression in follicular and luteal phase endometrium: a pilot study.
  Bentz EK, Kenning M, Schneeberger C, Kolbus A, Huber JC, Hefler LA, Tempfer CB
  Reprod Biol Endocrinol. 2010
  PubMed ID: 20412569
   
  
• Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells.
  Athanasiadou R, de Sousa D, Myant K, Merusi C, Stancheva I, Bird A
  PLoS One. 2010
  PubMed ID: 20376339
   
  
• Human haematopoietic stem cells express Oct4 pseudogenes and lack the ability to initiate Oct4 promoter-driven gene expression.
  Redshaw Z, Strain AJ
  J Negat Results Biomed. 2010
  PubMed ID: 20356403
   
  
• Single cell RT-PCR on mouse embryos: a general approach for developmental biology.
  Mann W, Haaf T
  Methods Mol Biol. 2010
  PubMed ID: 20300987
   
  
• A reprogrammable mouse strain from gene-targeted embryonic stem cells.
  Stadtfeld M, Maherali N, Borkent M, Hochedlinger K
  Nat Methods. 2010
  PubMed ID: 20010832
   
  
• Sexually dimorphic gene expression of the Zimp7 and Zimp10 genes in embryonic gonads.
  Rodríguez-Magadán H, Ramírez L, Schnabel D, Vázquez M, Lomelí H
  Gene Expr Patterns. 2010
  PubMed ID: 19931425
   
  
• Dicer is required for Sertoli cell function and survival.
  Kim GJ, Georg I, Scherthan H, Merkenschlager M, Guillou F, Scherer G, Barrionuevo F
  Int J Dev Biol. 2010
  PubMed ID: 19876815
   
  
• Gonadal defects in Cited2-mutant mice indicate a role for SF1 in both testis and ovary differentiation.
  Combes AN, Spiller CM, Harley VR, Sinclair AH, Dunwoodie SL, Wilhelm D, Koopman P
  Int J Dev Biol. 2010
  PubMed ID: 19757380
   
  
• Fetal testis dysgenesis and compromised Leydig cell function in Tgfbr3 (beta glycan) knockout mice.
  Sarraj MA, Escalona RM, Umbers A, Chua HK, Small C, Griswold M, Loveland K, Findlay JK, Stenvers KL
  Biol Reprod. 2010
  PubMed ID: 19696014
   
  
• The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.
  Krentz AD, Murphy MW, Kim S, Cook MS, Capel B, Zhu R, Matin A, Sarver AL, Parker KL, Griswold MD, Looijenga LH, Bardwell VJ, Zarkower D
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 20007774
   
  
• Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease.
  Molero AE, Gokhan S, Gonzalez S, Feig JL, Alexandre LC, Mehler MF
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19955426
   
  
• The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3.
  Suzuki H, Sada A, Yoshida S, Saga Y
  Dev Biol. 2009
  PubMed ID: 19818747
   
  
• A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
  Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
  Dev Cell. 2009
  PubMed ID: 20059953
   
  
• The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.
  Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, Kondoh G, Okawa K, Chujo T, Suzuki T, Hata K, Martin SL, Noce T, Kuramochi-Miyagawa S, Nakano T, Sasaki H, Pillai RS, Nakatsuji N, Chuma S
  Dev Cell. 2009
  PubMed ID: 20059948
   
  
• The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2.
  Rybak A, Fuchs H, Hadian K, Smirnova L, Wulczyn EA, Michel G, Nitsch R, Krappmann D, Wulczyn FG
  Nat Cell Biol. 2009
  PubMed ID: 19898466
   
  
• Kinked tail mutation results in notochord defects in heterozygotes and distal visceral endoderm defects in homozygotes.
  Farkas DR, Chapman DL
  Dev Dyn. 2009
  PubMed ID: 19877283
   
  
• RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells.
  Ponnusamy MP, Deb S, Dey P, Chakraborty S, Rachagani S, Senapati S, Batra SK
  Stem Cells. 2009
  PubMed ID: 19821493
   
  
• Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming.
  Wei Z, Yang Y, Zhang P, Andrianakos R, Hasegawa K, Lyu J, Chen X, Bai G, Liu C, Pera M, Lu W
  Stem Cells. 2009
  PubMed ID: 19816951
   
  
• Rat alveolar type I cells proliferate, express OCT-4, and exhibit phenotypic plasticity in vitro.
  Gonzalez RF, Allen L, Dobbs LG
  Am J Physiol Lung Cell Mol Physiol. 2009
  PubMed ID: 19717550
   
  
• Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy.
  Saigusa S, Tanaka K, Toiyama Y, Yokoe T, Okugawa Y, Ioue Y, Miki C, Kusunoki M
  Ann Surg Oncol. 2009
  PubMed ID: 19657699
   
  
• Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells.
  Yu HB, Kunarso G, Hong FH, Stanton LW
  J Biol Chem. 2009
  PubMed ID: 19740739
   
  
• Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells.
  Yuan P, Han J, Guo G, Orlov YL, Huss M, Loh YH, Yaw LP, Robson P, Lim B, Ng HH
  Genes Dev. 2009
  PubMed ID: 19884257
   
  
• Embryoid bodies from mouse stem cells express oxytocin receptor, Oct-4 and DAZL.
  Stefanidis K, Loutradis D, Anastasiadou V, Beretsos P, Bletsa R, Dinopoulou V, Lekka K, Elenis E, Kiapekou E, Koussoulakos S, Fotinos A, Antsaklis A
  Biosystems. 2009
  PubMed ID: 19695304
   
  
• Novel epigenetic mechanisms that control pluripotency and quiescence of adult bone marrow-derived Oct4(+) very small embryonic-like stem cells.
  Shin DM, Zuba-Surma EK, Wu W, Ratajczak J, Wysoczynski M, Ratajczak MZ, Kucia M
  Leukemia. 2009
  PubMed ID: 19641521
   
  
• CARM1 is required in embryonic stem cells to maintain pluripotency and resist differentiation.
  Wu Q, Bruce AW, Jedrusik A, Ellis PD, Andrews RM, Langford CF, Glover DM, Zernicka-Goetz M
  Stem Cells. 2009
  PubMed ID: 19544422
   
  
• A method for isolating pluripotent/multipotent stem cells from blood by using the pluripotent and germ-line DAZL gene as a marker.
  Seligman J, Slavin S, Fabian I
  Stem Cells Dev. 2009
  PubMed ID: 19327014
   
  
• GATA3 is selectively expressed in the trophectoderm of peri-implantation embryo and directly regulates Cdx2 gene expression.
  Home P, Ray S, Dutta D, Bronshteyn I, Larson M, Paul S
  J Biol Chem. 2009
  PubMed ID: 19700764
   
  
• Neural stem cells express Oct-3/4.
  Chin JH, Shiwaku H, Goda O, Komuro A, Okazawa H
  Biochem Biophys Res Commun. 2009
  PubMed ID: 19664601
   
  
• Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
  Nishiyama A, Xin L, Sharov AA, Thomas M, Mowrer G, Meyers E, Piao Y, Mehta S, Yee S, Nakatake Y, Stagg C, Sharova L, Correa-Cerro LS, Bassey U, Hoang H, Kim E, Tapnio R, Qian Y, Dudekula D, Zalzman M, Li M, Falco G, Yang HT, Lee SL, Monti M, Stanghellini I, Islam MN, Nagaraja R, Goldberg I, Wang W, Longo DL, Schlessinger D, Ko MS
  Cell Stem Cell. 2009
  PubMed ID: 19796622
   
  
• High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
  Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA
  PLoS Genet. 2009
  PubMed ID: 19851445
   
  
• Direct reprogramming of human neural stem cells by OCT4.
  Kim JB, Greber B, Araúzo-Bravo MJ, Meyer J, Park KI, Zaehres H, Schöler HR
  Nature. 2009
  PubMed ID: 19718018
   
  
• Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo.
  Nichols J, Silva J, Roode M, Smith A
  Development. 2009
  PubMed ID: 19710168
   
  
• Nodal signaling via an autocrine pathway promotes proliferation of mouse spermatogonial stem/progenitor cells through Smad2/3 and Oct-4 activation.
  He Z, Jiang J, Kokkinaki M, Dym M
  Stem Cells. 2009
  PubMed ID: 19688838
   
  
• Mesenchymal to embryonic incomplete transition of human cells by chimeric OCT4/3 (POU5F1) with physiological co-activator EWS.
  Makino H, Toyoda M, Matsumoto K, Saito H, Nishino K, Fukawatase Y, Machida M, Akutsu H, Uyama T, Miyagawa Y, Okita H, Kiyokawa N, Fujino T, Ishikawa Y, Nakamura T, Umezawa A
  Exp Cell Res. 2009
  PubMed ID: 19559696
   
  
• Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.
  Monti M, Redi C
  Mol Reprod Dev. 2009
  PubMed ID: 19480014
   
  
• iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism.
  Martinez-Fernandez A, Nelson TJ, Yamada S, Reyes S, Alekseev AE, Perez-Terzic C, Ikeda Y, Terzic A
  Circ Res. 2009
  PubMed ID: 19696409
   
  
• A cell-autonomous role for WT1 in regulating Sry in vivo.
  Bradford ST, Wilhelm D, Bandiera R, Vidal V, Schedl A, Koopman P
  Hum Mol Genet. 2009
  PubMed ID: 19549635
   
  
• Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate.
  Stefanovic S, Abboud N, Désilets S, Nury D, Cowan C, Pucéat M
  J Cell Biol. 2009
  PubMed ID: 19736317
   
  
• Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.
  Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, Williams D, Wilhelm D, Koopman P, Flavell RA, Chi H, Ostrer H, Wells S, Cheeseman M, Greenfield A
  PLoS Biol. 2009
  PubMed ID: 19753101
   
  
• BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures.
  Hannan NR, Jamshidi P, Pera MF, Wolvetang EJ
  Cloning Stem Cells. 2009
  PubMed ID: 19751112
   
  
• The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.
  Tzvetkov MV, Vormfelde SV, Balen D, Meineke I, Schmidt T, Sehrt D, Sabolić I, Koepsell H, Brockmöller J
  Clin Pharmacol Ther. 2009
  PubMed ID: 19536068
   
  
• Effects of ectopic Nanog and Oct4 overexpression on mesenchymal stem cells.
  Liu TM, Wu YN, Guo XM, Hui JH, Lee EH, Lim B
  Stem Cells Dev. 2009
  PubMed ID: 19102659
   
  
• Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation.
  Papapetrou EP, Tomishima MJ, Chambers SM, Mica Y, Reed E, Menon J, Tabar V, Mo Q, Studer L, Sadelain M
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19549847
   
  
• Protein chip analysis of pluripotency-associated proteins in NIH3T3 fibroblast.
  Ajjappala BS, Kim MS, Kim EY, Kim JH, Kang IC, Baek KH
  Proteomics. 2009
  PubMed ID: 19701907
   
  
• Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells.
  Sun C, Nakatake Y, Akagi T, Ura H, Matsuda T, Nishiyama A, Koide H, Ko MS, Niwa H, Yokota T
  Mol Cell Biol. 2009
  PubMed ID: 19528230
   
  
• Testicular mixed germ cell tumors: a morphological and immunohistochemical study using stem cell markers, OCT3/4, SOX2 and GDF3, with emphasis on morphologically difficult-to-classify areas.
  Gopalan A, Dhall D, Olgac S, Fine SW, Korkola JE, Houldsworth J, Chaganti RS, Bosl GJ, Reuter VE, Tickoo SK
  Mod Pathol. 2009
  PubMed ID: 19396148
   
  
• Implication of human OCT4 transactivation domains for self-regulatory transcription.
  Lim HY, Do HJ, Lee WY, Kim DK, Seo HG, Chung HJ, Park JK, Chang WK, Kim JH, Kim JH
  Biochem Biophys Res Commun. 2009
  PubMed ID: 19445899
   
  
• The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting.
  Donohoe ME, Silva SS, Pinter SF, Xu N, Lee JT
  Nature. 2009
  PubMed ID: 19536159
   
  
• Expression of Scl in mesoderm rescues hematopoiesis in the absence of Oct-4.
  Kong KY, Williamson EA, Rogers JH, Tran T, Hromas R, Dahl R
  Blood. 2009
  PubMed ID: 19321862
   
  
• Embryonic stem cell transcription factors and D2-40 (podoplanin) as diagnostic immunohistochemical markers in ovarian germ cell tumors.
  Chang MC, Vargas SO, Hornick JL, Hirsch MS, Crum CP, Nucci MR
  Int J Gynecol Pathol. 2009
  PubMed ID: 19483629
   
  
• Genes involved in regulation of stem cell properties: studies on their expression in a small cohort of neuroblastoma patients.
  Melone MA, Giuliano M, Squillaro T, Alessio N, Casale F, Mattioli E, Cipollaro M, Giordano A, Galderisi U
  Cancer Biol Ther. 2009
  PubMed ID: 19458492
   
  
• Simultaneous overexpression of Oct4 and Nanog abrogates terminal myogenesis.
  Lang KC, Lin IH, Teng HF, Huang YC, Li CL, Tang KT, Chen SL
  Am J Physiol Cell Physiol. 2009
  PubMed ID: 19403798
   
  
• OCT4A contributes to the stemness and multi-potency of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs).
  Seo KW, Lee SR, Bhandari DR, Roh KH, Park SB, So AY, Jung JW, Seo MS, Kang SK, Lee YS, Kang KS
  Biochem Biophys Res Commun. 2009
  PubMed ID: 19394308
   
  
• The expression of pluripotency marker Oct 3/4 in prostate cancer and benign prostate hyperplasia.
  Monsef N, Soller M, Isaksson M, Abrahamsson PA, Panagopoulos I
  Prostate. 2009
  PubMed ID: 19274762
   
  
• Alternative translation of OCT4 by an internal ribosome entry site and its novel function in stress response.
  Wang X, Zhao Y, Xiao Z, Chen B, Wei Z, Wang B, Zhang J, Han J, Gao Y, Li L, Zhao H, Zhao W, Lin H, Dai J
  Stem Cells. 2009
  PubMed ID: 19489092
   
  
• Oct-4A isoform is expressed in human cord blood-derived CD133 stem cells and differentiated progeny.
  Howe M, Zhao J, Bodenburg Y, McGuckin CP, Forraz N, Tilton RG, Urban RJ, Denner L
  Cell Prolif. 2009
  PubMed ID: 19438894
   
  
• The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation.
  Moniot B, Declosmenil F, Barrionuevo F, Scherer G, Aritake K, Malki S, Marzi L, Cohen-Solal A, Georg I, Klattig J, Englert C, Kim Y, Capel B, Eguchi N, Urade Y, Boizet-Bonhoure B, Poulat F
  Development. 2009
  PubMed ID: 19429785
   
  
• Oct4, a novel marker for human gastric cancer.
  Chen Z, Xu WR, Qian H, Zhu W, Bu XF, Wang S, Yan YM, Mao F, Gu HB, Cao HL, Xu XJ
  J Surg Oncol. 2009
  PubMed ID: 19347886
   
  
• The cerebellin 4 precursor gene is a direct target of SRY and SOX9 in mice.
  Bradford ST, Hiramatsu R, Maddugoda MP, Bernard P, Chaboissier MC, Sinclair A, Schedl A, Harley V, Kanai Y, Koopman P, Wilhelm D
  Biol Reprod. 2009
  PubMed ID: 19211811
   
  
• Efficient genetic reprogramming of unmodified somatic neural progenitors uncovers the essential requirement of Oct4 and Klf4.
  Di Stefano B, Prigione A, Broccoli V
  Stem Cells Dev. 2009
  PubMed ID: 18724799
   
  
• MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells.
  Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS
  Cell. 2009
  PubMed ID: 19409607
   
  
• Mutation in the DNA-binding domain of the EWS-Oct-4 oncogene results in dominant negative activity that interferes with EWS-Oct-4-mediated transactivation.
  Kim S, Lee J, Kim JY, Lim B, Shin EK, Han YM, Kim SS, Song JH, Kim J
  Int J Cancer. 2009
  PubMed ID: 19170206
   
  
• The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway.
  Cui M, Aras R, Christian WV, Rappold PM, Hatwar M, Panza J, Jackson-Lewis V, Javitch JA, Ballatori N, Przedborski S, Tieu K
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19416912
   
  
• Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.
  Combes AN, Lesieur E, Harley VR, Sinclair AH, Little MH, Wilhelm D, Koopman P
  Dev Dyn. 2009
  PubMed ID: 19334288
   
  
• WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells.
  Xu H, Wang W, Li C, Yu H, Yang A, Wang B, Jin Y
  Cell Res. 2009
  PubMed ID: 19274063
   
  
• Oct4 is expressed in human gliomas and promotes colony formation in glioma cells.
  Du Z, Jia D, Liu S, Wang F, Li G, Zhang Y, Cao X, Ling EA, Hao A
  Glia. 2009
  PubMed ID: 18985733
   
  
• Oct3/4 and Sox2 are significantly associated with an unfavorable clinical outcome in human esophageal squamous cell carcinoma.
  Wang Q, He W, Lu C, Wang Z, Wang J, Giercksky KE, Nesland JM, Suo Z
  Anticancer Res. 2009
  PubMed ID: 19414369
   
  
• Specific knockdown of OCT4 in human embryonic stem cells by inducible short hairpin RNA interference.
  Zafarana G, Avery SR, Avery K, Moore HD, Andrews PW
  Stem Cells. 2009
  PubMed ID: 19350677
   
  
• Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern.
  Lee HJ, Pazin DE, Kahlon RS, Correa SM, Albrecht KH
  Dev Dyn. 2009
  PubMed ID: 19301398
   
  
• Involvement of the organic cation transporters in histamine uptake into human vascular endothelial cells.
  Cerne K, Krzan M
  Inflamm Res. 2009
  PubMed ID: 19271143
   
  
• OCT4 expression in human non-small cell lung cancer: implications for therapeutic intervention.
  Karoubi G, Gugger M, Schmid R, Dutly A
  Interact Cardiovasc Thorac Surg. 2009
  PubMed ID: 19126554
   
  
• Abnormal DNA methylation of the Oct-4 enhancer region in cloned mouse embryos.
  Kawasumi M, Unno Y, Matsuoka T, Nishiwaki M, Anzai M, Amano T, Mitani T, Kato H, Saeki K, Hosoi Y, Iritani A, Kishigami S, Matsumoto K
  Mol Reprod Dev. 2009
  PubMed ID: 18932201
   
  
• Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development.
  Jin Z, Liu L, Bian W, Chen Y, Xu G, Cheng L, Jing N
  J Biol Chem. 2009
  PubMed ID: 19147497
   
  
• A positive regulatory role for the mSin3A-HDAC complex in pluripotency through Nanog and Sox2.
  Baltus GA, Kowalski MP, Tutter AV, Kadam S
  J Biol Chem. 2009
  PubMed ID: 19139101
   
  
• Cdk2ap1 is required for epigenetic silencing of Oct4 during murine embryonic stem cell differentiation.
  Deshpande AM, Dai YS, Kim Y, Kim J, Kimlin L, Gao K, Wong DT
  J Biol Chem. 2009
  PubMed ID: 19117947
   
  
• The Allantoic Core Domain: new insights into development of the murine allantois and its relation to the primitive streak.
  Downs KM, Inman KE, Jin DX, Enders AC
  Dev Dyn. 2009
  PubMed ID: 19191225
   
  
• Sox9-dependent expression of Gstm6 in Sertoli cells during testis development in mice.
  Beverdam A, Svingen T, Bagheri-Fam S, Bernard P, McClive P, Robson M, Khojasteh MB, Salehi M, Sinclair AH, Harley VR, Koopman P
  Reproduction. 2009
  PubMed ID: 19098141
   
  
• Oct4A is expressed by a subpopulation of prostate neuroendocrine cells.
  Sotomayor P, Godoy A, Smith GJ, Huss WJ
  Prostate. 2009
  PubMed ID: 19058139
   
  
• Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility.
  Greenbaum MP, Iwamori N, Agno JE, Matzuk MM
  Biol Reprod. 2009
  PubMed ID: 19020301
   
  
• Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage.
  Akamatsu W, DeVeale B, Okano H, Cooney AJ, van der Kooy D
  J Neurosci. 2009
  PubMed ID: 19228964
   
  
• Expression of human organic cation transporter 3 in kidney carcinoma cell lines increases chemosensitivity to melphalan, irinotecan, and vincristine.
  Shnitsar V, Eckardt R, Gupta S, Grottker J, Müller GA, Koepsell H, Burckhardt G, Hagos Y
  Cancer Res. 2009
  PubMed ID: 19190342
   
  
• Sfrp1 and Sfrp2 are required for normal male sexual development in mice.
  Warr N, Siggers P, Bogani D, Brixey R, Pastorelli L, Yates L, Dean CH, Wells S, Satoh W, Shimono A, Greenfield A
  Dev Biol. 2009
  PubMed ID: 19100252
   
  
• Expression of transcription factor Oct4 in bladder cancer cell line T24 and its effects on the biological characteristics of the cells.
  Zhu Z, Wen J, Zheng X, Wang D, Wang Q, Fan C
  J Huazhong Univ Sci Technolog Med Sci. 2009
  PubMed ID: 19224167
   
  
• Essential and overlapping functions for mammalian Argonautes in microRNA silencing.
  Su H, Trombly MI, Chen J, Wang X
  Genes Dev. 2009
  PubMed ID: 19174539
   
  
• Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb.
  Feng B, Jiang J, Kraus P, Ng JH, Heng JC, Chan YS, Yaw LP, Zhang W, Loh YH, Han J, Vega VB, Cacheux-Rataboul V, Lim B, Lufkin T, Ng HH
  Nat Cell Biol. 2009
  PubMed ID: 19136965
   
  
• Analysis of OCT4 expression in an extended panel of human tumor cell lines from multiple entities and in human mesenchymal stem cells.
  Mueller T, Luetzkendorf J, Nerger K, Schmoll HJ, Mueller LP
  Cell Mol Life Sci. 2009
  PubMed ID: 19023518
   
  
• Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo.
  Yamamoto M, Beppu H, Takaoka K, Meno C, Li E, Miyazono K, Hamada H
  J Cell Biol. 2009
  PubMed ID: 19153222
   
  
• A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress.
  Kang J, Gemberling M, Nakamura M, Whitby FG, Handa H, Fairbrother WG, Tantin D
  Genes Dev. 2009
  PubMed ID: 19171782
   
  
• Role of Oct-4 during acquisition of developmental competence in mouse oocyte.
  Zuccotti M, Merico V, Redi CA, Bellazzi R, Adjaye J, Garagna S
  Reprod Biomed Online. 2009
  PubMed ID: 20034424
   
  
• Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development.
  Costello I, Biondi CA, Taylor JM, Bikoff EK, Robertson EJ
  BMC Dev Biol. 2009
  PubMed ID: 19849841
   
  
• Isolation of Oct4-expressing extraembryonic endoderm precursor cell lines.
  Debeb BG, Galat V, Epple-Farmer J, Iannaccone S, Woodward WA, Bader M, Iannaccone P, Binas B
  PLoS One. 2009
  PubMed ID: 19784378
   
  
• Regulation of adipose tissue stromal cells behaviors by endogenic Oct4 expression control.
  Kim JH, Jee MK, Lee SY, Han TH, Kim BS, Kang KS, Kang SK
  PLoS One. 2009
  PubMed ID: 19777066
   
  
• Two factor reprogramming of human neural stem cells into pluripotency.
  Hester ME, Song S, Miranda CJ, Eagle A, Schwartz PH, Kaspar BK
  PLoS One. 2009
  PubMed ID: 19763260
   
  
• Foxl2 functions in sex determination and histogenesis throughout mouse ovary development.
  Garcia-Ortiz JE, Pelosi E, Omari S, Nedorezov T, Piao Y, Karmazin J, Uda M, Cao A, Cole SW, Forabosco A, Schlessinger D, Ottolenghi C
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• O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development.
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  BMC Dev Biol. 2009
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• Post-translational regulation of Oct4 transcriptional activity.
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• Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia.
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• Dynamic transition of Dnmt3b expression in mouse pre- and early post-implantation embryos.
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  Gene Expr Patterns. 2009
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• Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres.
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  Biol Reprod. 2009
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• Zic2 is expressed in pluripotent cells in the blastocyst and adult brain expression overlaps with makers of neurogenesis.
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  Gene Expr Patterns. 2009
  PubMed ID: 18755297
   
  
• Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells.
  Zhang X, Zhang J, Wang T, Esteban MA, Pei D
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• Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells.
  Yang J, Chai L, Fowles TC, Alipio Z, Xu D, Fink LM, Ward DC, Ma Y
  Proc Natl Acad Sci U S A. 2008
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• Identification of karyopherin-alpha 2 as an Oct4 associated protein.
  Li X, Sun L, Jin Y
  J Genet Genomics. 2008
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• OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells.
  Atlasi Y, Mowla SJ, Ziaee SA, Gokhale PJ, Andrews PW
  Stem Cells. 2008
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• Novel variants of Oct-3/4 gene expressed in mouse somatic cells.
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• Reprogramming and Differentiation in Mammals: Motifs and Mechanisms.
  De Vries WN, Evsikov AV, Brogan LJ, Anderson CP, Graber JH, Knowles BB, Solter D
  Cold Spring Harb Symp Quant Biol. 2008
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• Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.
  Shi Y, Desponts C, Do JT, Hahm HS, Schöler HR, Ding S
  Cell Stem Cell. 2008
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• Ovarian development in mice requires the GATA4-FOG2 transcription complex.
  Manuylov NL, Smagulova FO, Leach L, Tevosian SG
  Development. 2008
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• Transcriptional regulator BPTF/FAC1 is essential for trophoblast differentiation during early mouse development.
  Goller T, Vauti F, Ramasamy S, Arnold HH
  Mol Cell Biol. 2008
  PubMed ID: 18794365
   
  
• Spermatogonial stem cell self-renewal requires OCT4, a factor downregulated during retinoic acid-induced differentiation.
  Dann CT, Alvarado AL, Molyneux LA, Denard BS, Garbers DL, Porteus MH
  Stem Cells. 2008
  PubMed ID: 18719224
   
  
• Zfp143 regulates Nanog through modulation of Oct4 binding.
  Chen X, Fang F, Liou YC, Ng HH
  Stem Cells. 2008
  PubMed ID: 18687992
   
  
• MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation.
  Tay Y, Zhang J, Thomson AM, Lim B, Rigoutsos I
  Nature. 2008
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• Dynamic GATA6 expression in primitive endoderm formation and maturation in early mouse embryogenesis.
  Cai KQ, Capo-Chichi CD, Rula ME, Yang DH, Xu XX
  Dev Dyn. 2008
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• Epigenetic deregulation of the human Oct4 promoter in mouse cells.
  Cha Y, Sung MK, Jung KW, Kim HH, Lee SM, Park KS
  Dev Genes Evol. 2008
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• Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
  Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
  Genome Res. 2008
  PubMed ID: 18799693
   
  
• Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells.
  Card DA, Hebbar PB, Li L, Trotter KW, Komatsu Y, Mishina Y, Archer TK
  Mol Cell Biol. 2008
  PubMed ID: 18710938
   
  
• Blastomeres of the mouse embryo lose totipotency after the fifth cleavage division: expression of Cdx2 and Oct4 and developmental potential of inner and outer blastomeres of 16- and 32-cell embryos.
  Suwińska A, Czołowska R, Ozdzeński W, Tarkowski AK
  Dev Biol. 2008
  PubMed ID: 18692038
   
  
• Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression.
  van den Berg DL, Zhang W, Yates A, Engelen E, Takacs K, Bezstarosti K, Demmers J, Chambers I, Poot RA
  Mol Cell Biol. 2008
  PubMed ID: 18662995
   
  
• Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation.
  Warr N, Powles-Glover N, Chappell A, Robson J, Norris D, Arkell RM
  Hum Mol Genet. 2008
  PubMed ID: 18617531
   
  
• Molecular coupling of Xist regulation and pluripotency.
  Navarro P, Chambers I, Karwacki-Neisius V, Chureau C, Morey C, Rougeulle C, Avner P
  Science. 2008
  PubMed ID: 18802003
   
  
• A subcortical maternal complex essential for preimplantation mouse embryogenesis.
  Li L, Baibakov B, Dean J
  Dev Cell. 2008
  PubMed ID: 18804437
   
  
• Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo.
  Uez N, Lickert H, Kohlhase J, de Angelis MH, Kühn R, Wurst W, Floss T
  Genesis. 2008
  PubMed ID: 18781635
   
  
• In vivo osteoprogenitor potency of human stromal cells from different tissues does not correlate with expression of POU5F1 or its pseudogenes.
  Kaltz N, Funari A, Hippauf S, Delorme B, Noël D, Riminucci M, Jacobs VR, Häupl T, Jorgensen C, Charbord P, Peschel C, Bianco P, Oostendorp RA
  Stem Cells. 2008
  PubMed ID: 18617685
   
  
• Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland.
  Strizzi L, Mancino M, Bianco C, Raafat A, Gonzales M, Booth BW, Watanabe K, Nagaoka T, Mack DL, Howard B, Callahan R, Smith GH, Salomon DS
  J Cell Physiol. 2008
  PubMed ID: 18425773
   
  
• Identification of DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays.
  Chakravarthy H, Boer B, Desler M, Mallanna SK, McKeithan TW, Rizzino A
  J Cell Physiol. 2008
  PubMed ID: 18366076
   
  
• Klf5 is involved in self-renewal of mouse embryonic stem cells.
  Parisi S, Passaro F, Aloia L, Manabe I, Nagai R, Pastore L, Russo T
  J Cell Sci. 2008
  PubMed ID: 18653541
   
  
• Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression.
  Gupta P, Ho PC, Huq MM, Ha SG, Park SW, Khan AA, Tsai NP, Wei LN
  Proc Natl Acad Sci U S A. 2008
  PubMed ID: 18682553
   
  
• Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells.
  Chang CC, Shieh GS, Wu P, Lin CC, Shiau AL, Wu CL
  Cancer Res. 2008
  PubMed ID: 18676852
   
  
• Critical function of Prdm14 for the establishment of the germ cell lineage in mice.
  Yamaji M, Seki Y, Kurimoto K, Yabuta Y, Yuasa M, Shigeta M, Yamanaka K, Ohinata Y, Saitou M
  Nat Genet. 2008
  PubMed ID: 18622394
   
  
• Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster.
  Lange UC, Adams DJ, Lee C, Barton S, Schneider R, Bradley A, Surani MA
  Mol Cell Biol. 2008
  PubMed ID: 18505827
   
  
• T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways.
  Tam WL, Lim CY, Han J, Zhang J, Ang YS, Ng HH, Yang H, Lim B
  Stem Cells. 2008
  PubMed ID: 18467660
   
  
• Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells.
  Fong H, Hohenstein KA, Donovan PJ
  Stem Cells. 2008
  PubMed ID: 18388306
   
  
• Stem cell-specific expression of Dax1 is conferred by STAT3 and Oct3/4 in embryonic stem cells.
  Sun C, Nakatake Y, Ura H, Akagi T, Niwa H, Koide H, Yokota T
  Biochem Biophys Res Commun. 2008
  PubMed ID: 18471437
   
  
• Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma.
  Chiou SH, Yu CC, Huang CY, Lin SC, Liu CJ, Tsai TH, Chou SH, Chien CS, Ku HH, Lo JF
  Clin Cancer Res. 2008
  PubMed ID: 18593985
   
  
• Hepatoblast-like cells enriched from mouse embryonic stem cells in medium without glucose, pyruvate, arginine, and tyrosine.
  Tomizawa M, Toyama Y, Ito C, Toshimori K, Iwase K, Takiguchi M, Saisho H, Yokosuka O
  Cell Tissue Res. 2008
  PubMed ID: 18478268
   
  
• Noninvasive detection of testicular carcinoma in situ in semen using OCT3/4.
  van Casteren NJ, Stoop H, Dohle GR, de Wit R, Oosterhuis JW, Looijenga LH
  Eur Urol. 2008
  PubMed ID: 17996359
   
  
• Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice.
  Kurimoto K, Yabuta Y, Ohinata Y, Shigeta M, Yamanaka K, Saitou M
  Genes Dev. 2008
  PubMed ID: 18559478
   
  
• Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo.
  Lupu F, Alves A, Anderson K, Doye V, Lacy E
  Dev Cell. 2008
  PubMed ID: 18539113
   
  
• Differential expression of the embryo/cancer gene ECSA(DPPA2), the cancer/testis gene BORIS and the pluripotency structural gene OCT4, in human preimplantation development.
  Monk M, Hitchins M, Hawes S
  Mol Hum Reprod. 2008
  PubMed ID: 18467432
   
  
• Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells.
  Liang J, Wan M, Zhang Y, Gu P, Xin H, Jung SY, Qin J, Wong J, Cooney AJ, Liu D, Songyang Z
  Nat Cell Biol. 2008
  PubMed ID: 18454139
   
  
• Oct4 is epigenetically regulated by methylation in normal placenta and gestational trophoblastic disease.
  Zhang HJ, Siu MK, Wong ES, Wong KY, Li AS, Chan KY, Ngan HY, Cheung AN
  Placenta. 2008
  PubMed ID: 18440631
   
  
• Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways.
  Suzuki H, Tsuda M, Kiso M, Saga Y
  Dev Biol. 2008
  PubMed ID: 18436203
   
  
• Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse.
  Wang H, Ding T, Brown N, Yamamoto Y, Prince LS, Reese J, Paria BC
  Dev Biol. 2008
  PubMed ID: 18423437
   
  
• Simultaneous expression of Oct4 and genes of three germ layers in single cell-derived multipotent adult progenitor cells.
  Ji KH, Xiong J, Hu KM, Fan LX, Liu HQ
  Ann Hematol. 2008
  PubMed ID: 18338169
   
  
• Participation of OCT3/4 and beta-catenin during dysgenetic gonadal malignant transformation.
  Palma I, Peña RY, Contreras A, Ceballos-Reyes G, Coyote N, Eraña L, Kofman-Alfaro S, Queipo G
  Cancer Lett. 2008
  PubMed ID: 18295396
   
  
• Requirement of Oct3/4 function for germ cell specification.
  Okamura D, Tokitake Y, Niwa H, Matsui Y
  Dev Biol. 2008
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• ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a.
  Gao X, Tate P, Hu P, Tjian R, Skarnes WC, Wang Z
  Proc Natl Acad Sci U S A. 2008
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• [Unique principles in early mammalian development]
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  Tanpakushitsu Kakusan Koso. 2008
  PubMed ID: 18453147
   
  
• Immunohistochemical localization of nanog and Oct4 in stem cell compartments of human sacrococcygeal teratomas.
  Busch C, Oppitz M, Wehrmann M, Schweizer P, Drews U
  Histopathology. 2008
  PubMed ID: 18439155
   
  
• Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary.
  Chassot AA, Ranc F, Gregoire EP, Roepers-Gajadien HL, Taketo MM, Camerino G, de Rooij DG, Schedl A, Chaboissier MC
  Hum Mol Genet. 2008
  PubMed ID: 18250098
   
  
• The early human germ cell lineage does not express SOX2 during in vivo development or upon in vitro culture.
  Perrett RM, Turnpenny L, Eckert JJ, O'Shea M, Sonne SB, Cameron IT, Wilson DI, Meyts ER, Hanley NA
  Biol Reprod. 2008
  PubMed ID: 18199879
   
  
• STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells.
  Ura H, Usuda M, Kinoshita K, Sun C, Mori K, Akagi T, Matsuda T, Koide H, Yokota T
  J Biol Chem. 2008
  PubMed ID: 18201968
   
  
• Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity.
  Endoh M, Endo TA, Endoh T, Fujimura Y, Ohara O, Toyoda T, Otte AP, Okano M, Brockdorff N, Vidal M, Koseki H
  Development. 2008
  PubMed ID: 18339675
   
  
• GUDMAP: the genitourinary developmental molecular anatomy project.
  McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
  J Am Soc Nephrol. 2008
  PubMed ID: 18287559
   
  
• Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms.
  Kristensen DM, Nielsen JE, Skakkebaek NE, Graem N, Jacobsen GK, Rajpert-De Meyts E, Leffers H
  Hum Reprod. 2008
  PubMed ID: 18281244
   
  
• [Identification of the OCT4-pg1 retrogene and NANOG gene expression in the human embryonic eye]
  Firsova NV, Markintantova IuV, Smirnova IuA, Panova IG, Sukhikh GT, Zinov'eva RD, Mitashov VI
  Izv Akad Nauk Ser Biol. 2008
  PubMed ID: 18946985
   
  
• Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells.
  Levasseur DN, Wang J, Dorschner MO, Stamatoyannopoulos JA, Orkin SH
  Genes Dev. 2008
  PubMed ID: 18283123
   
  
• Tex19, a mammalian-specific protein with a restricted expression in pluripotent stem cells and germ line.
  Kuntz S, Kieffer E, Bianchetti L, Lamoureux N, Fuhrmann G, Viville S
  Stem Cells. 2008
  PubMed ID: 18096721
   
  
• Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos.
  Nishioka N, Yamamoto S, Kiyonari H, Sato H, Sawada A, Ota M, Nakao K, Sasaki H
  Mech Dev. 2008
  PubMed ID: 18083014
   
  
• Absence of OCT4 expression in somatic tumor cell lines.
  Cantz T, Key G, Bleidissel M, Gentile L, Han DW, Brenne A, Schöler HR
  Stem Cells. 2008
  PubMed ID: 18032701
   
  
• Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells.
  Brambrink T, Foreman R, Welstead GG, Lengner CJ, Wernig M, Suh H, Jaenisch R
  Cell Stem Cell. 2008
  PubMed ID: 18371436
   
  
• Independent prognostic value of the basal-like phenotype of breast cancer and associations with EGFR and candidate stem cell marker BMI-1.
  Arnes JB, Collett K, Akslen LA
  Histopathology. 2008
  PubMed ID: 18269588
   
  
• Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors.
  Iczkowski KA, Butler SL, Shanks JH, Hossain D, Schall A, Meiers I, Zhou M, Torkko KC, Kim SJ, MacLennan GT
  Hum Pathol. 2008
  PubMed ID: 18045648
   
  
• Reprogramming of human somatic cells to pluripotency with defined factors.
  Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, Daley GQ
  Nature. 2008
  PubMed ID: 18157115
   
  
• The Maestro (Mro) gene is dispensable for normal sexual development and fertility in mice.
  Smith L, Willan J, Warr N, Brook FA, Cheeseman M, Sharpe R, Siggers P, Greenfield A
  PLoS ONE. 2008
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• RBM19 is essential for preimplantation development in the mouse.
  Zhang J, Tomasini AJ, Mayer AN
  BMC Dev Biol. 2008
  PubMed ID: 19087264
   
  
• Generating iPS cells from MEFS through forced expression of Sox-2, Oct-4, c-Myc, and Klf4.
  Welstead GG, Brambrink T, Jaenisch R
  J Vis Exp. 2008
  PubMed ID: 19066578
   
  
• The zinc finger SET domain gene Prdm14 is overexpressed in lymphoblastic lymphomas with retroviral insertions at Evi32.
  Dettman EJ, Justice MJ
  PLoS ONE. 2008
  PubMed ID: 19043588
   
  
• Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes.
  Zuccotti M, Merico V, Sacchi L, Bellone M, Brink TC, Bellazzi R, Stefanelli M, Redi CA, Garagna S, Adjaye J
  BMC Dev Biol. 2008
  PubMed ID: 18837968
   
  
• Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells.
  Chen YC, Hsu HS, Chen YW, Tsai TH, How CK, Wang CY, Hung SC, Chang YL, Tsai ML, Lee YY, Ku HH, Chiou SH
  PLoS ONE. 2008
  PubMed ID: 18612434
   
  
• B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells.
  Tarasov KV, Tarasova YS, Tam WL, Riordon DR, Elliott ST, Kania G, Li J, Yamanaka S, Crider DG, Testa G, Li RA, Lim B, Stewart CL, Liu Y, Van Eyk JE, Wersto RP, Wobus AM, Boheler KR
  PLoS ONE. 2008
  PubMed ID: 18575582
   
  
• Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data.
  Sharov AA, Masui S, Sharova LV, Piao Y, Aiba K, Matoba R, Xin L, Niwa H, Ko MS
  BMC Genomics. 2008
  PubMed ID: 18522731
   
  
• Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency.
  Kunarso G, Wong KY, Stanton LW, Lipovich L
  BMC Genomics. 2008
  PubMed ID: 18400104
   
  
• Sequence variation in the human transcription factor gene POU5F1.
  Hussain SK, Sequerra R, Bertucci C, Hastings NC, Rieder M, Schwartz SM
  BMC Genet. 2008
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• Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription.
  Lee J, Kim HK, Han YM, Kim J
  Int J Biochem Cell Biol. 2008
  PubMed ID: 18191611
   
  
• Primary mediastinal seminoma: a comprehensive assessment integrated with histology, immunohistochemistry, and fluorescence in situ hybridization for chromosome 12p abnormalities in 23 cases.
  Sung MT, Maclennan GT, Lopez-Beltran A, Zhang S, Montironi R, Cheng L
  Am J Surg Pathol. 2008
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• Oct-4 is critical for survival/antiapoptosis of murine embryonic stem cells subjected to stress: effects associated with Stat3/survivin.
  Guo Y, Mantel C, Hromas RA, Broxmeyer HE
  Stem Cells. 2008
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• Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci.
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• Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.
  Hanna J, Wernig M, Markoulaki S, Sun CW, Meissner A, Cassady JP, Beard C, Brambrink T, Wu LC, Townes TM, Jaenisch R
  Science. 2007
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• PIAS proteins as repressors of Oct4 function.
  Tolkunova E, Malashicheva A, Parfenov VN, Sustmann C, Grosschedl R, Tomilin A
  J Mol Biol. 2007
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• Expression and significance of Oct4 in bladder cancer.
  Xu K, Zhu Z, Zeng F
  J Huazhong Univ Sci Technolog Med Sci. 2007
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• Genomic analysis of gastrulation and organogenesis in the mouse.
  Mitiku N, Baker JC
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• Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis.
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  Dev Biol. 2007
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• Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog.
  Li JY, Pu MT, Hirasawa R, Li BZ, Huang YN, Zeng R, Jing NH, Chen T, Li E, Sasaki H, Xu GL
  Mol Cell Biol. 2007
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• Functional similarities among genes regulated by OCT4 in human mesenchymal and embryonic stem cells.
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• Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
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• Identifying genes differentially expressed between PGCs and ES cells reveals a role for CREB-binding protein in germ cell survival.
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• Beta-catenin signaling contributes to stemness and regulates early differentiation in murine embryonic stem cells.
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• Manipulation of OCT4 levels in human embryonic stem cells results in induction of differential cell types.
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• PU.1 (Sfpi1), a pleiotropic regulator expressed from the first embryonic stages with a crucial function in germinal progenitors.
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• Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development.
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• Aberrant expression and distribution of the OCT-4 transcription factor in seminomas.
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• A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung.
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• Oct4 expression is not required for mouse somatic stem cell self-renewal.
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• Origin of climbing fiber neurons and their developmental dependence on Ptf1a.
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• Novel germ cell markers characterize testicular seminoma and fetal testis.
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• Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells.
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  Nat Biotechnol. 2007
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• Retinoic acid, meiosis and germ cell fate in mammals.
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• GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion.
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  Mol Biol Cell. 2007
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• Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1.
  Zhang Z, Liao B, Xu M, Jin Y
  FASEB J. 2007
  PubMed ID: 17496161
   
  
• Successful co-immunoprecipitation of Oct4 and Nanog using cross-linking.
  Zhang L, Rayner S, Katoku-Kikyo N, Romanova L, Kikyo N
  Biochem Biophys Res Commun. 2007
  PubMed ID: 17669361
   
  
• Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.
  Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, Yancopoulos GD, Murphy A, Valenzuela DM, Hobbs RM, Pandolfi PP, Rafii S
  Nature. 2007
  PubMed ID: 17882221
   
  
• EUCOMM--the European conditional mouse mutagenesis program.
  Friedel RH, Seisenberger C, Kaloff C, Wurst W
  Brief Funct Genomic Proteomic. 2007
  PubMed ID: 17967808
   
  
• BMP signalling inhibits premature neural differentiation in the mouse embryo.
  Di-Gregorio A, Sancho M, Stuckey DW, Crompton LA, Godwin J, Mishina Y, Rodriguez TA
  Development. 2007
  PubMed ID: 17699604
   
  
• Mice lacking the Obox6 homeobox gene undergo normal early embryonic development and are fertile.
  Cheng WC, Hsieh-Li HM, Yeh YJ, Li H
  Dev Dyn. 2007
  PubMed ID: 17676645
   
  
• Sex-specific differences in mouse DMRT1 expression are both cell type- and stage-dependent during gonad development.
  Lei N, Hornbaker KI, Rice DA, Karpova T, Agbor VA, Heckert LL
  Biol Reprod. 2007
  PubMed ID: 17567962
   
  
• Transcriptional regulation of human Oct4 by steroidogenic factor-1.
  Yang HM, Do HJ, Kim DK, Park JK, Chang WK, Chung HM, Choi SY, Kim JH
  J Cell Biochem. 2007
  PubMed ID: 17226773
   
  
• Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation.
  Wei F, Schöler HR, Atchison ML
  J Biol Chem. 2007
  PubMed ID: 17525163
   
  
• In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.
  Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein BE, Jaenisch R
  Nature. 2007
  PubMed ID: 17554336
   
  
• Zscan4: a novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells.
  Falco G, Lee SL, Stanghellini I, Bassey UC, Hamatani T, Ko MS
  Dev Biol. 2007
  PubMed ID: 17553482
   
  
• A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells.
  Li J, Pan G, Cui K, Liu Y, Xu S, Pei D
  J Biol Chem. 2007
  PubMed ID: 17507372
   
  
• X chromosome reactivation initiates in nascent primordial germ cells in mice.
  Sugimoto M, Abe K
  PLoS Genet. 2007
  PubMed ID: 17676999
   
  
• Differential methylation of the OCT3/4 upstream region in primary human testicular germ cell tumors.
  De Jong J, Weeda S, Gillis AJ, Oosterhuis JW, Looijenga LH
  Oncol Rep. 2007
  PubMed ID: 17549357
   
  
• Oct-4 expression in adult human differentiated cells challenges its role as a pure stem cell marker.
  Zangrossi S, Marabese M, Broggini M, Giordano R, D'Erasmo M, Montelatici E, Intini D, Neri A, Pesce M, Rebulla P, Lazzari L
  Stem Cells. 2007
  PubMed ID: 17379765
   
  
• POU-V factors antagonize maternal VegT activity and beta-Catenin signaling in Xenopus embryos.
  Cao Y, Siegel D, Donow C, Knöchel S, Yuan L, Knöchel W
  EMBO J. 2007
  PubMed ID: 17541407
   
  
• Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.
  Maherali N, Sridharan R, Xie W, Utikal J, Eminli S, Arnold K, Stadtfeld M, Yachechko R, Tchieu J, Jaenisch R, Plath K, Hochedlinger K
  Cell Stem Cell. 2007
  PubMed ID: 18371336
   
  
• Prenatal development of murine gonads with special reference to germ cell differentiation: a morphological and immunohistochemical study.
  Zayed AE, Abd-Elnaeim MM, Abd-Elghaffar SKh, Hild A, Brehm R, Steger K
  Andrologia. 2007
  PubMed ID: 17683469
   
  
• Knockdown of Oct-4 or Sox-2 attenuates neurogenesis of mouse embryonic stem cells.
  Chen S, Choo AB, Nai-Dy W, Heng-Phon T, Oh SK
  Stem Cells Dev. 2007
  PubMed ID: 17610371
   
  
• A high-resolution anatomical ontology of the developing murine genitourinary tract.
  Little MH, Brennan J, Georgas K, Davies JA, Davidson DR, Baldock RA, Beverdam A, Bertram JF, Capel B, Chiu HS, Clements D, Cullen-McEwen L, Fleming J, Gilbert T, Herzlinger D, Houghton D, Kaufman MH, Kleymenova E, Koopman PA, Lewis AG, McMahon AP, Mendelsohn CL, Mitchell EK, Rumballe BA, Sweeney DE, Valerius MT, Yamada G, Yang Y, Yu J
  Gene Expr Patterns. 2007
  PubMed ID: 17452023
   
  
• One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation.
  Morita S, Horii T, Kimura M, Goto Y, Ochiya T, Hatada I
  Genomics. 2007
  PubMed ID: 17418524
   
  
• Oct-4, Rex-1, and Gata-4 expression in human MSC increase the differentiation efficiency but not hTERT expression.
  Roche S, Richard MJ, Favrot MC
  J Cell Biochem. 2007
  PubMed ID: 17211834
   
  
• Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation.
  Svingen T, Beverdam A, Bernard P, McClive P, Harley VR, Sinclair AH, Koopman P
  Reproduction. 2007
  PubMed ID: 17616727
   
  
• Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs.
  Katoh M, Katoh M
  Int J Oncol. 2007
  PubMed ID: 17390031
   
  
• Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract.
  Freberg CT, Dahl JA, Timoskainen S, Collas P
  Mol Biol Cell. 2007
  PubMed ID: 17314394
   
  
• The genetic polymorphisms of POU5F1 gene are associated with psoriasis vulgaris in Chinese.
  Chang YT, Hsu CY, Chou CT, Lin MW, Shiao YM, Tsai CY, Yu CW, Shiue JJ, Lee YF, Huang CH, Chen CC, Lee DD, Wang WJ, Liu HN, Tsai SF
  J Dermatol Sci. 2007
  PubMed ID: 17314032
   
  
• Expression of Wsb2 in the developing and adult mouse testis.
  Sarraj MA, McClive PJ, Szczepny A, Daggag H, Loveland KL, Sinclair AH
  Reproduction. 2007
  PubMed ID: 17504919
   
  
• Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.
  Pollard PJ, Spencer-Dene B, Shukla D, Howarth K, Nye E, El-Bahrawy M, Deheragoda M, Joannou M, McDonald S, Martin A, Igarashi P, Varsani-Brown S, Rosewell I, Poulsom R, Maxwell P, Stamp GW, Tomlinson IP
  Cancer Cell. 2007
  PubMed ID: 17418408
   
  
• Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis?
  Howell NR, Zheng W, Cheng L, Tornos C, Kane P, Pearl M, Chalas E, Liang SX
  Int J Gynecol Pathol. 2007
  PubMed ID: 17413979
   
  
• SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development.
  Wilhelm D, Hiramatsu R, Mizusaki H, Widjaja L, Combes AN, Kanai Y, Koopman P
  J Biol Chem. 2007
  PubMed ID: 17277314
   
  
• OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer.
  Atlasi Y, Mowla SJ, Ziaee SA, Bahrami AR
  Int J Cancer. 2007
  PubMed ID: 17205510
   
  
• Stem cell regulatory function mediated by expression of a novel mouse Oct4 pseudogene.
  Lin H, Shabbir A, Molnar M, Lee T
  Biochem Biophys Res Commun. 2007
  PubMed ID: 17280643
   
  
• Maternal microRNAs are essential for mouse zygotic development.
  Tang F, Kaneda M, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA
  Genes Dev. 2007
  PubMed ID: 17369397
   
  
• Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.
  Kaji K, Nichols J, Hendrich B
  Development. 2007
  PubMed ID: 17287250
   
  
• Crucial role of Bysl in mammalian preimplantation development as an integral factor for 40S ribosome biogenesis.
  Adachi K, Soeta-Saneyoshi C, Sagara H, Iwakura Y
  Mol Cell Biol. 2007
  PubMed ID: 17242206
   
  
• Male fetal germ cells are targets for androgens that physiologically inhibit their proliferation.
  Merlet J, Racine C, Moreau E, Moreno SG, Habert R
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17360691
   
  
• GABPalpha regulates Oct-3/4 expression in mouse embryonic stem cells.
  Kinoshita K, Ura H, Akagi T, Usuda M, Koide H, Yokota T
  Biochem Biophys Res Commun. 2007
  PubMed ID: 17194449
   
  
• Morphological and molecular characterization of novel population of CXCR4+ SSEA-4+ Oct-4+ very small embryonic-like cells purified from human cord blood: preliminary report.
  Kucia M, Halasa M, Wysoczynski M, Baskiewicz-Masiuk M, Moldenhawer S, Zuba-Surma E, Czajka R, Wojakowski W, Machalinski B, Ratajczak MZ
  Leukemia. 2007
  PubMed ID: 17136117
   
  
• Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells.
  Babaie Y, Herwig R, Greber B, Brink TC, Wruck W, Groth D, Lehrach H, Burdon T, Adjaye J
  Stem Cells. 2007
  PubMed ID: 17068183
   
  
• De-differentiation of mouse interfollicular keratinocytes by the embryonic transcription factor Oct-4.
  Grinnell KL, Yang B, Eckert RL, Bickenbach JR
  J Invest Dermatol. 2007
  PubMed ID: 16932739
   
  
• Dicer1 expression in preimplantation mouse embryos: Involvement of Oct3/4 transcription at the blastocyst stage.
  Cui XS, Shen XH, Kim NH
  Biochem Biophys Res Commun. 2007
  PubMed ID: 17113034
   
  
• Bmp7 regulates germ cell proliferation in mouse fetal gonads.
  Ross A, Munger S, Capel B
  Sex Dev. 2007
  PubMed ID: 18391523
   
  
• Conserved and divergent patterns of expression of DAZL, VASA and OCT4 in the germ cells of the human fetal ovary and testis.
  Anderson RA, Fulton N, Cowan G, Coutts S, Saunders PT
  BMC Dev Biol. 2007
  PubMed ID: 18088417
   
  
• Polony analysis of gene expression in ES cells and blastocysts.
  Rieger C, Poppino R, Sheridan R, Moley K, Mitra R, Gottlieb D
  Nucleic Acids Res. 2007
  PubMed ID: 18073198
   
  
• Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas.
  McGowan SL, Edelhauser HF, Pfister RR, Whikehart DR
  Mol Vis. 2007
  PubMed ID: 17982423
   
  
• Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor.
  Joshi S, Davies H, Sims LP, Levy SE, Dean J
  BMC Dev Biol. 2007
  PubMed ID: 17567914
   
  
• Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal.
  Greber B, Lehrach H, Adjaye J
  BMC Dev Biol. 2007
  PubMed ID: 17506876
   
  
• Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation.
  Svingen T, Beverdam A, Verma P, Wilhelm D, Koopman P
  Int J Dev Biol. 2007
  PubMed ID: 17486547
   
  
• Oct-3/4: not just a gatekeeper of pluripotency for embryonic stem cell, a cell fate instructor through a gene dosage effect.
  Stefanovic S, Pucéat M
  Cell Cycle. 2007
  PubMed ID: 17245123
   
  
• SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells.
  Park SW, Hu X, Gupta P, Lin YP, Ha SG, Wei LN
  Nat Struct Mol Biol. 2007
  PubMed ID: 17187077
   
  
• Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm.
  Kan NG, Stemmler MP, Junghans D, Kanzler B, de Vries WN, Dominis M, Kemler R
  Development. 2007
  PubMed ID: 17138661
   
  
• Dppa2 and Dppa4 are closely linked SAP motif genes restricted to pluripotent cells and the germ line.
  Maldonado-Saldivia J, van den Bergen J, Krouskos M, Gilchrist M, Lee C, Li R, Sinclair AH, Surani MA, Western PS
  Stem Cells. 2007
  PubMed ID: 16990585
   
  
• Inhibition of DNA binding of Sox2 by the SUMO conjugation.
  Tsuruzoe S, Ishihara K, Uchimura Y, Watanabe S, Sekita Y, Aoto T, Saitoh H, Yuasa Y, Niwa H, Kawasuji M, Baba H, Nakao M
  Biochem Biophys Res Commun. 2006
  PubMed ID: 17097055
   
  
• POU5F1 isoforms show different expression patterns in human embryonic stem cells and preimplantation embryos.
  Cauffman G, Liebaers I, Van Steirteghem A, Van de Velde H
  Stem Cells. 2006
  PubMed ID: 16916925
   
  
• Characterization of NOBOX DNA binding specificity and its regulation of Gdf9 and Pou5f1 promoters.
  Choi Y, Rajkovic A
  J Biol Chem. 2006
  PubMed ID: 16997917
   
  
• A protein interaction network for pluripotency of embryonic stem cells.
  Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, Orkin SH
  Nature. 2006
  PubMed ID: 17093407
   
  
• The human OCT-4 isoforms differ in their ability to confer self-renewal.
  Lee J, Kim HK, Rho JY, Han YM, Kim J
  J Biol Chem. 2006
  PubMed ID: 16951404
   
  
• Murine inner cell mass-derived lineages depend on Sall4 function.
  Elling U, Klasen C, Eisenberger T, Anlag K, Treier M
  Proc Natl Acad Sci U S A. 2006
  PubMed ID: 17060609
   
  
• Nuclear and chromatin reorganization in the MHC-Oct3/4 locus at developmental phases of embryonic stem cell differentiation.
  Aoto T, Saitoh N, Ichimura T, Niwa H, Nakao M
  Dev Biol. 2006
  PubMed ID: 16950240
   
  
• Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells.
  Nakatake Y, Fukui N, Iwamatsu Y, Masui S, Takahashi K, Yagi R, Yagi K, Miyazaki J, Matoba R, Ko MS, Niwa H
  Mol Cell Biol. 2006
  PubMed ID: 16954384
   
  
• Stage-specific Importin13 activity influences meiosis of germ cells in the mouse.
  Yamaguchi YL, Tanaka SS, Yasuda K, Matsui Y, Tam PP
  Dev Biol. 2006
  PubMed ID: 16908015
   
  
• Use of Chuk as an internal standard suitable for quantitative RT-PCR in mouse preimplantation embryos.
  Falco G, Stanghellini I, Ko MS
  Reprod Biomed Online. 2006
  PubMed ID: 16984773
   
  
• Loss of the mouse ortholog of the shwachman-diamond syndrome gene (Sbds) results in early embryonic lethality.
  Zhang S, Shi M, Hui CC, Rommens JM
  Mol Cell Biol. 2006
  PubMed ID: 16914746
   
  
• Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels.
  Bosman EA, Lawson KA, Debruyn J, Beek L, Francis A, Schoonjans L, Huylebroeck D, Zwijsen A
  Development. 2006
  PubMed ID: 16887830
   
  
• Disruption of early proximodistal patterning and AVE formation in Apc mutants.
  Chazaud C, Rossant J
  Development. 2006
  PubMed ID: 16887818
   
  
• Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
  Takahashi K, Yamanaka S
  Cell. 2006
  PubMed ID: 16904174
   
  
• Dissecting self-renewal in stem cells with RNA interference.
  Ivanova N, Dobrin R, Lu R, Kotenko I, Levorse J, DeCoste C, Schafer X, Lun Y, Lemischka IR
  Nature. 2006
  PubMed ID: 16767105
   
  
• Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets.
  Tanaka TS, Lopez de Silanes I, Sharova LV, Akutsu H, Yoshikawa T, Amano H, Yamanaka S, Gorospe M, Ko MS
  Dev Growth Differ. 2006
  PubMed ID: 16872451
   
  
• The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development.
  Sakaki-Yumoto M, Kobayashi C, Sato A, Fujimura S, Matsumoto Y, Takasato M, Kodama T, Aburatani H, Asashima M, Yoshida N, Nishinakamura R
  Development. 2006
  PubMed ID: 16790473
   
  
• Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?
  Costa Y, Speed RM, Gautier P, Semple CA, Maratou K, Turner JM, Cooke HJ
  Hum Mol Genet. 2006
  PubMed ID: 16787967
   
  
• Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells.
  Yamaguchi YL, Tanaka SS, Kasa M, Yasuda K, Tam PP, Matsui Y
  Gene Expr Patterns. 2006
  PubMed ID: 16434236
   
  
• Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development.
  Gonzalez MA, Tachibana KE, Adams DJ, van der Weyden L, Hemberger M, Coleman N, Bradley A, Laskey RA
  Genes Dev. 2006
  PubMed ID: 16847348
   
  
• The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.
  Chen HJ, Lin CM, Lin CS, Perez-Olle R, Leung CL, Liem RK
  Genes Dev. 2006
  PubMed ID: 16815997
   
  
• The mouse gcd2 mutation causes primordial germ cell depletion.
  Reinholdt LG, Munroe RJ, Kamdar S, Schimenti JC
  Mech Dev. 2006
  PubMed ID: 16822657
   
  
• Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.
  Shiina T, Ota M, Shimizu S, Katsuyama Y, Hashimoto N, Takasu M, Anzai T, Kulski JK, Kikkawa E, Naruse T, Kimura N, Yanagiya K, Watanabe A, Hosomichi K, Kohara S, Iwamoto C, Umehara Y, Meyer A, Wanner V, Sano K, Macquin C, Ikeo K, Tokunaga K, Gojobori T, Inoko H, Bahram S
  Genetics. 2006
  PubMed ID: 16702430
   
  
• Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro.
  Ling TY, Kuo MD, Li CL, Yu AL, Huang YH, Wu TJ, Lin YC, Chen SH, Yu J
  Proc Natl Acad Sci U S A. 2006
  PubMed ID: 16772384
   
  
• The orphan nuclear receptor GCNF recruits DNA methyltransferase for Oct-3/4 silencing.
  Sato N, Kondo M, Arai K
  Biochem Biophys Res Commun. 2006
  PubMed ID: 16631596
   
  
• Gonadotropins affect Oct-4 gene expression during mouse oocyte growth.
  Monti M, Garagna S, Redi C, Zuccotti M
  Mol Reprod Dev. 2006
  PubMed ID: 16496425
   
  
• Differentiation of mouse embryonic stem cells after RNA interference-mediated silencing of OCT4 and Nanog.
  Hough SR, Clements I, Welch PJ, Wiederholt KA
  Stem Cells. 2006
  PubMed ID: 16456133
   
  
• Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8.
  Pangas SA, Choi Y, Ballow DJ, Zhao Y, Westphal H, Matzuk MM, Rajkovic A
  Proc Natl Acad Sci U S A. 2006
  PubMed ID: 16690745
   
  
• Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway.
  Chazaud C, Yamanaka Y, Pawson T, Rossant J
  Dev Cell. 2006
  PubMed ID: 16678776
   
  
• The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells.
  Cormier S, Le Bras S, Souilhol C, Vandormael-Pournin S, Durand B, Babinet C, Baldacci P, Cohen-Tannoudji M
  Mol Cell Biol. 2006
  PubMed ID: 16611995
   
  
• The matricellular protein SPARC is internalized in Sertoli, Leydig, and germ cells during testis differentiation.
  Wilson MJ, Bowles J, Koopman P
  Mol Reprod Dev. 2006
  PubMed ID: 16425238
   
  
• BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
  Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
  PLoS Biol. 2006
  PubMed ID: 16602821
   
  
• The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells.
  Loh YH, Wu Q, Chew JL, Vega VB, Zhang W, Chen X, Bourque G, George J, Leong B, Liu J, Wong KY, Sung KW, Lee CW, Zhao XD, Chiu KP, Lipovich L, Kuznetsov VA, Robson P, Stanton LW, Wei CL, Ruan Y, Lim B, Ng HH
  Nat Genet. 2006
  PubMed ID: 16518401
   
  
• The mouse T complex gene Tsga2, encoding polypeptides located in the sperm tail and anterior acrosome, maps to a locus associated with sperm motility and sperm-egg interaction abnormalities.
  Hui L, Lu J, Han Y, Pilder SH
  Biol Reprod. 2006
  PubMed ID: 16354795
   
  
• HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.
  Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B
  Genes Dev. 2006
  PubMed ID: 16510872
   
  
• Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development.
  Georgiades P, Rossant J
  Development. 2006
  PubMed ID: 16481355
   
  
• Zic3 is critical for early embryonic patterning during gastrulation.
  Ware SM, Harutyunyan KG, Belmont JW
  Dev Dyn. 2006
  PubMed ID: 16397896
   
  
• Deconstructing mammalian reproduction: using knockouts to define fertility pathways.
  Roy A, Matzuk MM
  Reproduction. 2006
  PubMed ID: 16452715
   
  
• G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis.
  Feldman N, Gerson A, Fang J, Li E, Zhang Y, Shinkai Y, Cedar H, Bergman Y
  Nat Cell Biol. 2006
  PubMed ID: 16415856
   
  
• Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers.
  Kerkis I, Kerkis A, Dozortsev D, Stukart-Parsons GC, Gomes Massironi SM, Pereira LV, Caplan AI, Cerruti HF
  Cells Tissues Organs. 2006
  PubMed ID: 17409736
   
  
• Dissecting Oct3/4-regulated gene networks in embryonic stem cells by expression profiling.
  Matoba R, Niwa H, Masui S, Ohtsuka S, Carter MG, Sharov AA, Ko MS
  PLoS One. 2006
  PubMed ID: 17183653
   
  
• Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro.
  Baharvand H, Hashemi SM, Kazemi Ashtiani S, Farrokhi A
  Int J Dev Biol. 2006
  PubMed ID: 16892178
   
  
• Undifferentiated mouse mesenchymal stem cells spontaneously express neural and stem cell markers Oct-4 and Rex-1.
  Lamoury FM, Croitoru-Lamoury J, Brew BJ
  Cytotherapy. 2006
  PubMed ID: 16793732
   
  
• The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.
  Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M
  Nucleic Acids Res. 2006
  PubMed ID: 16582099
   
  
• Loss of Oct-3/4 expression in embryonal carcinoma cells is associated with induction of cisplatin resistance.
  Mueller T, Mueller LP, Luetzkendorf J, Voigt W, Simon H, Schmoll HJ
  Tumour Biol. 2006
  PubMed ID: 16557044
   
  
• Oct-4 expression in human endometrium.
  Matthai C, Horvat R, Noe M, Nagele F, Radjabi A, van Trotsenburg M, Huber J, Kolbus A
  Mol Hum Reprod. 2006
  PubMed ID: 16421218
   
  
• A novel subpopulation lacking Oct4 expression in the testicular side population.
  Shimizu Y, Motohashi N, Iseki H, Kunita S, Sugiyama F, Yagami K
  Int J Mol Med. 2006
  PubMed ID: 16328007
   
  
• High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization.
  Yoshikawa T, Piao Y, Zhong J, Matoba R, Carter MG, Wang Y, Goldberg I, Ko MS
  Gene Expr Patterns. 2006
  PubMed ID: 16325481
   
  
• Dazl deficiency leads to embryonic arrest of germ cell development in XY C57BL/6 mice.
  Lin Y, Page DC
  Dev Biol. 2005
  PubMed ID: 16310179
   
  
• Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation.
  Niwa H, Toyooka Y, Shimosato D, Strumpf D, Takahashi K, Yagi R, Rossant J
  Cell. 2005
  PubMed ID: 16325584
   
  
• Oct4 pseudogenes are transcribed in cancers.
  Suo G, Han J, Wang X, Zhang J, Zhao Y, Zhao Y, Dai J
  Biochem Biophys Res Commun. 2005
  PubMed ID: 16229821
   
  
• Expression of the Gas7 gene and Oct4 in embryonic stem cells of mice.
  Moorthy PP, Kumar AA, Devaraj H
  Stem Cells Dev. 2005
  PubMed ID: 16433621
   
  
• IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion.
  Tanaka SS, Yamaguchi YL, Tsoi B, Lickert H, Tam PP
  Dev Cell. 2005
  PubMed ID: 16326387
   
  
• The roles of FGF signaling in germ cell migration in the mouse.
  Takeuchi Y, Molyneaux K, Runyan C, Schaible K, Wylie C
  Development. 2005
  PubMed ID: 16291796
   
  
• Characterization of putative cis-regulatory elements that control the transcriptional activity of the human Oct4 promoter.
  Yang HM, Do HJ, Oh JH, Kim JH, Choi SY, Cha KY, Chung HM, Kim JH
  J Cell Biochem. 2005
  PubMed ID: 16149048
   
  
• Annexin XI co-localises with calcyclin in proliferating cells of the embryonic mouse testis.
  Williams LH, McClive PJ, Van Den Bergen JA, Sinclair AH
  Dev Dyn. 2005
  PubMed ID: 16127703
   
  
• Core transcriptional regulatory circuitry in human embryonic stem cells.
  Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA
  Cell. 2005
  PubMed ID: 16153702
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Variable reprogramming of the pluripotent stem cell marker Oct4 in mouse clones: distinct developmental potentials in different culture environments.
  Boiani M, Gentile L, Gambles VV, Cavaleri F, Redi CA, Schöler HR
  Stem Cells. 2005
  PubMed ID: 15955835
   
  
• Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia.
  Barrow KM, Ward CM, Rutter J, Ali S, Stern PL
  Dev Dyn. 2005
  PubMed ID: 15977177
   
  
• Osteopontin and related SIBLING glycoprotein genes are expressed by Sertoli cells during mouse testis development.
  Wilson MJ, Liaw L, Koopman P
  Dev Dyn. 2005
  PubMed ID: 15937924
   
  
• The intron 5/6 promoter region of the ship1 gene regulates expression in stem/progenitor cells of the mouse embryo.
  Rohrschneider LR, Custodio JM, Anderson TA, Miller CP, Gu H
  Dev Biol. 2005
  PubMed ID: 15978570
   
  
• Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein.
  Artus J, Vandormael-Pournin S, Frödin M, Nacerddine K, Babinet C, Cohen-Tannoudji M
  Mol Cell Biol. 2005
  PubMed ID: 15988037
   
  
• Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells.
  Chew JL, Loh YH, Zhang W, Chen X, Tam WL, Yeap LS, Li P, Ang YS, Lim B, Robson P, Ng HH
  Mol Cell Biol. 2005
  PubMed ID: 15988017
   
  
• Sox3 expression in undifferentiated spermatogonia is required for the progression of spermatogenesis.
  Raverot G, Weiss J, Park SY, Hurley L, Jameson JL
  Dev Biol. 2005
  PubMed ID: 15893302
   
  
• Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells.
  Maruyama M, Ichisaka T, Nakagawa M, Yamanaka S
  J Biol Chem. 2005
  PubMed ID: 15863505
   
  
• Transcriptional regulation of nanog by OCT4 and SOX2.
  Rodda DJ, Chew JL, Lim LH, Loh YH, Wang B, Ng HH, Robson P
  J Biol Chem. 2005
  PubMed ID: 15860457
   
  
• Oct-3/4 maintains the proliferative embryonic stem cell state via specific binding to a variant octamer sequence in the regulatory region of the UTF1 locus.
  Nishimoto M, Miyagi S, Yamagishi T, Sakaguchi T, Niwa H, Muramatsu M, Okuda A
  Mol Cell Biol. 2005
  PubMed ID: 15923625
   
  
• Stimulation of Oct-4 activity by Ewing's sarcoma protein.
  Lee J, Rhee BK, Bae GY, Han YM, Kim J
  Stem Cells. 2005
  PubMed ID: 15917470
   
  
• EWSR1 is fused to POU5F1 in a bone tumor with translocation t(6;22)(p21;q12).
  Yamaguchi S, Yamazaki Y, Ishikawa Y, Kawaguchi N, Mukai H, Nakamura T
  Genes Chromosomes Cancer. 2005
  PubMed ID: 15729702
   
  
• The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts.
  Haines BP, Gupta R, Jones CM, Summerbell D, Rigby PW
  Dev Biol. 2005
  PubMed ID: 15893969
   
  
• Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues.
  Hochedlinger K, Yamada Y, Beard C, Jaenisch R
  Cell. 2005
  PubMed ID: 15882627
   
  
• A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad.
  Matsuyama M, Mizusaki H, Shimono A, Mukai T, Okumura K, Abe K, Shimada K, Morohashi K
  Genes Cells. 2005
  PubMed ID: 15836771
   
  
• Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development.
  Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, Galardi C, Peng L, Latour AM, Koller BH, Gossen J, Kliewer SA, Cooney AJ
  Mol Cell Biol. 2005
  PubMed ID: 15831456
   
  
• Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning.
  Donnison M, Beaton A, Davey HW, Broadhurst R, L'Huillier P, Pfeffer PL
  Development. 2005
  PubMed ID: 15829518
   
  
• Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst.
  Strumpf D, Mao CA, Yamanaka Y, Ralston A, Chawengsaksophak K, Beck F, Rossant J
  Development. 2005
  PubMed ID: 15788452
   
  
• Identification of mouse blastocyst genes that are downregulated by double-stranded RNA-mediated knockdown of Oct-4 expression.
  Shin MR, Cui XS, Jun JH, Jeong YJ, Kim NH
  Mol Reprod Dev. 2005
  PubMed ID: 15685634
   
  
• High-efficiency RNA interference in human embryonic stem cells.
  Zaehres H, Lensch MW, Daheron L, Stewart SA, Itskovitz-Eldor J, Daley GQ
  Stem Cells. 2005
  PubMed ID: 15749924
   
  
• Oct-4 mRNA and protein expression during human preimplantation development.
  Cauffman G, Van de Velde H, Liebaers I, Van Steirteghem A
  Mol Hum Reprod. 2005
  PubMed ID: 15695770
   
  
• PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2.
  Kato Y, Sai Y, Yoshida K, Watanabe C, Hirata T, Tsuji A
  Mol Pharmacol. 2005
  PubMed ID: 15523054
   
  
• Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation.
  Deb-Rinker P, Ly D, Jezierski A, Sikorska M, Walker PR
  J Biol Chem. 2005
  PubMed ID: 15615706
   
  
• Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells.
  Okumura-Nakanishi S, Saito M, Niwa H, Ishikawa F
  J Biol Chem. 2005
  PubMed ID: 15557334
   
  
• Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis.
  Tai MH, Chang CC, Kiupel M, Webster JD, Olson LK, Trosko JE
  Carcinogenesis. 2005
  PubMed ID: 15513931
   
  
• Heterogeneous DNA methylation status of the regulatory element of the mouse Oct4 gene in adult somatic cell population.
  Marikawa Y, Fujita TC, Alarcón VB
  Cloning Stem Cells. 2005
  PubMed ID: 15996113
   
  
• Stably transfected human embryonic stem cell clones express OCT4-specific green fluorescent protein and maintain self-renewal and pluripotency.
  Gerrard L, Zhao D, Clark AJ, Cui W
  Stem Cells. 2005
  PubMed ID: 15625129
   
  
• Phenotypic analyses of mouse embryos with ubiquitous expression of Oct4: effects on mid-hindbrain patterning and gene expression.
  Ramos-Mejía V, Escalante-Alcalde D, Kunath T, Ramírez L, Gertsenstein M, Nagy A, Lomelí H
  Dev Dyn. 2005
  PubMed ID: 15580630
   
  
• Mouse brain organization revealed through direct genome-scale TF expression analysis.
  Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
  Science. 2004
  PubMed ID: 15618518
   
  
• Oct-3/4 repression accelerates differentiation of neural progenitor cells in vitro and in vivo.
  Okuda T, Tagawa K, Qi ML, Hoshio M, Ueda H, Kawano H, Kanazawa I, Muramatsu M, Okazawa H
  Brain Res Mol Brain Res. 2004
  PubMed ID: 15548425
   
  
• Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast.
  Kemler R, Hierholzer A, Kanzler B, Kuppig S, Hansen K, Taketo MM, de Vries WN, Knowles BB, Solter D
  Development. 2004
  PubMed ID: 15525667
   
  
• Targeted disruption of the mouse ELYS gene results in embryonic death at peri-implantation development.
  Okita K, Kiyonari H, Nobuhisa I, Kimura N, Aizawa S, Taga T
  Genes Cells. 2004
  PubMed ID: 15507119
   
  
• Oct4 is required for primordial germ cell survival.
  Kehler J, Tolkunova E, Koschorz B, Pesce M, Gentile L, Boiani M, Lomelí H, Nagy A, McLaughlin KJ, Schöler HR, Tomilin A
  EMBO Rep. 2004
  PubMed ID: 15486564
   
  
• Establishing a germ cell origin for metastatic tumors using OCT4 immunohistochemistry.
  Cheng L
  Cancer. 2004
  PubMed ID: 15386301
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• Expression of transcription factor Oct-4 and other embryonic genes in CD133 positive cells from human umbilical cord blood.
  Baal N, Reisinger K, Jahr H, Bohle RM, Liang O, Münstedt K, Rao CV, Preissner KT, Zygmunt MT
  Thromb Haemost. 2004
  PubMed ID: 15467907
   
  
• Expression of the tudor-related gene Tdrd5 during development of the male germline in mice.
  Smith JM, Bowles J, Wilson M, Teasdale RD, Koopman P
  Gene Expr Patterns. 2004
  PubMed ID: 15465492
   
  
• OCT4: a novel biomarker for dysgerminoma of the ovary.
  Cheng L, Thomas A, Roth LM, Zheng W, Michael H, Karim FW
  Am J Surg Pathol. 2004
  PubMed ID: 15371950
   
  
• Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells.
  Catena R, Tiveron C, Ronchi A, Porta S, Ferri A, Tatangelo L, Cavallaro M, Favaro R, Ottolenghi S, Reinbold R, Schöler H, Nicolis SK
  J Biol Chem. 2004
  PubMed ID: 15262984
   
  
• Identification of a nuclear localization signal in OCT4 and generation of a dominant negative mutant by its ablation.
  Pan G, Qin B, Liu N, Schöler HR, Pei D
  J Biol Chem. 2004
  PubMed ID: 15218026
   
  
• NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression.
  Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM
  Science. 2004
  PubMed ID: 15326356
   
  
• Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo.
  Chu GC, Dunn NR, Anderson DC, Oxburgh L, Robertson EJ
  Development. 2004
  PubMed ID: 15215210
   
  
• The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation.
  Van Eynde A, Nuytten M, Dewerchin M, Schoonjans L, Keppens S, Beullens M, Moons L, Carmeliet P, Stalmans W, Bollen M
  Mol Cell Biol. 2004
  PubMed ID: 15199142
   
  
• Effect of ploidy and parental genome composition on expression of Oct-4 protein in mouse embryos.
  Liu L, Czerwiec E, Keefe DL
  Gene Expr Patterns. 2004
  PubMed ID: 15183310
   
  
• HMG box transcription factor gene Hbp1 is expressed in germ cells of the developing mouse testis.
  Smith JM, Bowles J, Wilson M, Koopman P
  Dev Dyn. 2004
  PubMed ID: 15162515
   
  
• The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice.
  Kelly OG, Pinson KI, Skarnes WC
  Development. 2004
  PubMed ID: 15142971
   
  
• Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads.
  Rajpert-De Meyts E, Hanstein R, Jørgensen N, Graem N, Vogt PH, Skakkebaek NE
  Hum Reprod. 2004
  PubMed ID: 15105401
   
  
• Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination.
  Xu HM, Liao B, Zhang QJ, Wang BB, Li H, Zhong XM, Sheng HZ, Zhao YX, Zhao YM, Jin Y
  J Biol Chem. 2004
  PubMed ID: 15047715
   
  
• Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human.
  Hart AH, Hartley L, Ibrahim M, Robb L
  Dev Dyn. 2004
  PubMed ID: 15108323
   
  
• Autocrine and paracrine mechanisms regulating primordial germ cell proliferation.
  Kawase E, Hashimoto K, Pedersen RA
  Mol Reprod Dev. 2004
  PubMed ID: 15039943
   
  
• Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells.
  Hattori N, Nishino K, Ko YG, Hattori N, Ohgane J, Tanaka S, Shiota K
  J Biol Chem. 2004
  PubMed ID: 14761969
   
  
• Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis.
  Natoli TA, Alberta JA, Bortvin A, Taglienti ME, Menke DB, Loring J, Jaenisch R, Page DC, Housman DE, Kreidberg JA
  Dev Biol. 2004
  PubMed ID: 15063178
   
  
• Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo.
  Dunn NR, Vincent SD, Oxburgh L, Robertson EJ, Bikoff EK
  Development. 2004
  PubMed ID: 15084457
   
  
• Eki2 is upregulated specifically in the testis during mouse sex determination.
  Hurley TM, McClive PJ, Sarraj MA, Sinclair AH
  Gene Expr Patterns. 2004
  PubMed ID: 15161093
   
  
• Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos.
  Mitsunaga K, Araki K, Mizusaki H, Morohashi K, Haruna K, Nakagata N, Giguère V, Yamamura K, Abe K
  Mech Dev. 2004
  PubMed ID: 15003627
   
  
• Initiation of gastrulation in the mouse embryo is preceded by an apparent shift in the orientation of the anterior-posterior axis.
  Perea-Gomez A, Camus A, Moreau A, Grieve K, Moneron G, Dubois A, Cibert C, Collignon J
  Curr Biol. 2004
  PubMed ID: 14761651
   
  
• Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and embryonic carcinoma cells.
  Matin MM, Walsh JR, Gokhale PJ, Draper JS, Bahrami AR, Morton I, Moore HD, Andrews PW
  Stem Cells. 2004
  PubMed ID: 15342930
   
  
• Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells.
  Hay DC, Sutherland L, Clark J, Burdon T
  Stem Cells. 2004
  PubMed ID: 14990861
   
  
• Molecular study of mouse peri-implantation development using the in vitro culture of aggregated inner cell mass.
  Alarcón VB, Marikawa Y
  Mol Reprod Dev. 2004
  PubMed ID: 14648878
   
  
• Hematopoietic progenitors express neural genes.
  Goolsby J, Marty MC, Heletz D, Chiappelli J, Tashko G, Yarnell D, Fishman PS, Dhib-Jalbut S, Bever CT, Pessac B, Trisler D
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 14634211
   
  
• Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.
  Xiao C, Shim JH, Klüppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S
  Genes Dev. 2003
  PubMed ID: 14633973
   
  
• Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.
  Morkel M, Huelsken J, Wakamiya M, Ding J, van de Wetering M, Clevers H, Taketo MM, Behringer RR, Shen MM, Birchmeier W
  Development. 2003
  PubMed ID: 14623818
   
  
• Lineage choice and differentiation in mouse embryos and embryonic stem cells.
  Loebel DA, Watson CM, De Young RA, Tam PP
  Dev Biol. 2003
  PubMed ID: 14623228
   
  
• Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
  Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 14610273
   
  
• Dicer is essential for mouse development.
  Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, Mills AA, Elledge SJ, Anderson KV, Hannon GJ
  Nat Genet. 2003
  PubMed ID: 14528307
   
  
• The DNA sequence and analysis of human chromosome 6.
  Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
  Nature. 2003
  PubMed ID: 14574404
   
  
• Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave.
  Menke DB, Koubova J, Page DC
  Dev Biol. 2003
  PubMed ID: 14550793
   
  
• Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad.
  McClive PJ, Hurley TM, Sarraj MA, van den Bergen JA, Sinclair AH
  Genesis. 2003
  PubMed ID: 14595844
   
  
• An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development.
  Saba-El-Leil MK, Vella FD, Vernay B, Voisin L, Chen L, Labrecque N, Ang SL, Meloche S
  EMBO Rep. 2003
  PubMed ID: 14502223
   
  
• Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death.
  Lykke-Andersen K, Schaefer L, Menon S, Deng XW, Miller JB, Wei N
  Mol Cell Biol. 2003
  PubMed ID: 12972599
   
  
• The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells.
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