ATRX

Summary Top Help

Gene Description:

alpha thalassemia/mental retardation syndrome X-linked; alpha thalassemia/mental retardation syndrome X-linked homolog (human)

Synonyms:

XNP, DXHXS6677E, MRXHF1, ZNF-HX, JMS, Atrx, XH2, ATR2, SFM1, SHS, MRXS3, HP1-BP38, Hp1bp2, RAD54L, ATRX, Hp1bp38, Rad54, Xnp, 4833408C14Rik, AI447451, RAD54

Orthologs:

Human ATRX (protein-coding), Mouse Atrx (protein-coding), Rat Atrx (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chrX:76760356..77041719 (281.36 kb) View in Genome Browser

(Mouse) NCBIM37 - chrX:103013409..103124736 (111.33 kb) View in Genome Browser

(Rat) RGSC3.4 - chrX:93903794..94051337 (147.54 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for ATRX:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for ATRX:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 20

Publications from PubMed Top Help

Publications: 166

Altered telomeres in tumors with ATRX and DAXX mutations.
Heaphy CM, de Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, Bettegowda C, Rodriguez FJ, Eberhart CG, Hebbar S, Offerhaus GJ, McLendon R, Rasheed BA, He Y, Yan H, Bigner DD, Oba-Shinjo SM, Marie SK, Riggins GJ, Kinzler KW, Vogelstein B, Hruban RH, Maitra A, Papadopoulos N, Meeker AK
Science. 2011
PubMed ID: 21719641
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome.
Iwase S, Xiang B, Ghosh S, Ren T, Lewis PW, Cochrane JC, Allis CD, Picketts DJ, Patel DJ, Li H, Shi Y
Nat Struct Mol Biol. 2011
PubMed ID: 21666679
Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin.
Eustermann S, Yang JC, Law MJ, Amos R, Chapman LM, Jelinska C, Garrick D, Clynes D, Gibbons RJ, Rhodes D, Higgs DR, Neuhaus D
Nat Struct Mol Biol. 2011
PubMed ID: 21666677
Functional significance of mutations in the Snf2 domain of ATRX.
Mitson M, Kelley LA, Sternberg MJ, Higgs DR, Gibbons RJ
Hum Mol Genet. 2011
PubMed ID: 21505078
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Over-expression of RAD51 or RAD54 but not RAD51/4 enhances extra-chromosomal homologous recombination in the human sarcoma (HT-1080) cell line.
Yu S, Song Z, Luo J, Dai Y, Li N
J Biotechnol. 2011
PubMed ID: 21501635
Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome.
Bagheri-Fam S, Argentaro A, Svingen T, Combes AN, Sinclair AH, Koopman P, Harley VR
Hum Mol Genet. 2011
PubMed ID: 21427128
The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9.
Dhayalan A, Tamas R, Bock I, Tattermusch A, Dimitrova E, Kudithipudi S, Ragozin S, Jeltsch A
Hum Mol Genet. 2011
PubMed ID: 21421568
Hybridisation-based resequencing of 17 X-linked intellectual disability genes in 135 patients reveals novel mutations in ATRX, SLC6A8 and PQBP1.
Jensen LR, Chen W, Moser B, Lipkowitz B, Schroeder C, Musante L, Tzschach A, Kalscheuer VM, Meloni I, Raynaud M, van Esch H, Chelly J, de Brouwer AP, Hackett A, van der Haar S, Henn W, Gecz J, Riess O, Bonin M, Reinhardt R, Ropers HH, Kuss AW
Eur J Hum Genet. 2011
PubMed ID: 21267006
Localization of the chromatin remodelling protein, ATRX in the adult testis.
Tang P, Argentaro A, Pask AJ, O'Donnell L, Marshall-Graves J, Familari M, Harley VR
J Reprod Dev. 2011
PubMed ID: 19444003
Human cytomegalovirus immediate early gene expression in the osteosarcoma line U2OS is repressed by the cell protein ATRX.
McFarlane S, Preston CM
Virus Res. 2011
PubMed ID: 21310198
Factors determining DNA double-strand break repair pathway choice in G2 phase.
Shibata A, Conrad S, Birraux J, Geuting V, Barton O, Ismail A, Kakarougkas A, Meek K, Taucher-Scholz G, Löbrich M, Jeggo PA
EMBO J. 2011
PubMed ID: 21317870
ATP-dependent and independent functions of Rad54 in genome maintenance.
Agarwal S, van Cappellen WA, Guénolé A, Eppink B, Linsen SE, Meijering E, Houtsmuller A, Kanaar R, Essers J
J Cell Biol. 2011
PubMed ID: 21357745
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, Schulick RD, Tang LH, Wolfgang CL, Choti MA, Velculescu VE, Diaz LA, Vogelstein B, Kinzler KW, Hruban RH, Papadopoulos N
Science. 2011
PubMed ID: 21252315
From strand exchange to branch migration; bypassing of non-homologous sequences by human Rad51 and Rad54.
Urena DE, Zhang Z, Tsai YC, Wang YZ, Chen J
J Mol Biol. 2011
PubMed ID: 21056573
Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.
Shioda N, Beppu H, Fukuda T, Li E, Kitajima I, Fukunaga K
J Neurosci. 2011
PubMed ID: 21209221
ATRX has a critical and conserved role in mammalian sexual differentiation.
Huyhn K, Renfree MB, Graves JA, Pask AJ
BMC Dev Biol. 2011
PubMed ID: 21672208
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke.
Li S, Overman JJ, Katsman D, Kozlov SV, Donnelly CJ, Twiss JL, Giger RJ, Coppola G, Geschwind DH, Carmichael ST
Nat Neurosci. 2010
PubMed ID: 21057507
ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.
Law MJ, Lower KM, Voon HP, Hughes JR, Garrick D, Viprakasit V, Mitson M, De Gobbi M, Marra M, Morris A, Abbott A, Wilder SP, Taylor S, Santos GM, Cross J, Ayyub H, Jones S, Ragoussis J, Rhodes D, Dunham I, Higgs DR, Gibbons RJ
Cell. 2010
PubMed ID: 21029860
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres.
Lewis PW, Elsaesser SJ, Noh KM, Stadler SC, Allis CD
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20651253
Phenotypic annotation of the mouse X chromosome.
Cox BJ, Vollmer M, Tamplin O, Lu M, Biechele S, Gertsenstein M, van Campenhout C, Floss T, Kühn R, Wurst W, Lickert H, Rossant J
Genome Res. 2010
PubMed ID: 20548051
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.
Drané P, Ouararhni K, Depaux A, Shuaib M, Hamiche A
Genes Dev. 2010
PubMed ID: 20504901
Novel interactors and a role for supervillin in early cytokinesis.
Smith TC, Fang Z, Luna EJ
Cytoskeleton (Hoboken). 2010
PubMed ID: 20309963
Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation.
Wang H, Zhang X, Wang P, Yu X, Essers J, Chen D, Kanaar R, Takeda S, Wang Y
Nucleic Acids Res. 2010
PubMed ID: 20150414
Regulation of ICP0-null mutant herpes simplex virus type 1 infection by ND10 components ATRX and hDaxx.
Lukashchuk V, Everett RD
J Virol. 2010
PubMed ID: 20147399
Strong relationship between NT-proXNP levels and cardiac output following cardiac surgery in neonates and infants.
Breuer T, Skoumal R, Horkay F, Merkely B, Ala-Kopsala M, Leppäluoto J, Vuolteenaho O, Ruskoaho H, Tóth M, Székely A
Acta Anaesthesiol Scand. 2010
PubMed ID: 19919584
Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice.
Nogami T, Beppu H, Tokoro T, Moriguchi S, Shioda N, Fukunaga K, Ohtsuka T, Ishii Y, Sasahara M, Shimada Y, Nishijo H, Li E, Kitajima I
Hippocampus. 2010
PubMed ID: 20865721
Distinct factors control histone variant H3.3 localization at specific genomic regions.
Goldberg AD, Banaszynski LA, Noh KM, Lewis PW, Elsaesser SJ, Stadler S, Dewell S, Law M, Guo X, Li X, Wen D, Chapgier A, DeKelver RC, Miller JC, Lee YL, Boydston EA, Holmes MC, Gregory PD, Greally JM, Rafii S, Yang C, Scambler PJ, Garrick D, Gibbons RJ, Higgs DR, Cristea IM, Urnov FD, Zheng D, Allis CD
Cell. 2010
PubMed ID: 20211137
ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells.
Wong LH, McGhie JD, Sim M, Anderson MA, Ahn S, Hannan RD, George AJ, Morgan KA, Mann JR, Choo KH
Genome Res. 2010
PubMed ID: 20110566
ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain.
Kernohan KD, Jiang Y, Tremblay DC, Bonvissuto AC, Eubanks JH, Mann MR, Bérubé NG
Dev Cell. 2010
PubMed ID: 20159591
Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and pre-implantation embryo.
Baumann C, Viveiros MM, De La Fuente R
PLoS Genet. 2010
PubMed ID: 20885787
DNA ligase IV as a new molecular target for temozolomide.
Kondo N, Takahashi A, Mori E, Ohnishi K, McKinnon PJ, Sakaki T, Nakase H, Ohnishi T
Biochem Biophys Res Commun. 2009
PubMed ID: 19615340
Partial ATRX gene duplication causes ATR-X syndrome.
Cohn DM, Pagon RA, Hudgins L, Schwartz CE, Stevenson RE, Friez MJ
Am J Med Genet A. 2009
PubMed ID: 19764021
BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54.
Srivastava V, Modi P, Tripathi V, Mudgal R, De S, Sengupta S
J Cell Sci. 2009
PubMed ID: 19671661
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation.
Kalantry S, Purushothaman S, Bowen RB, Starmer J, Magnuson T
Nature. 2009
PubMed ID: 19571810
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ
Mol Cell Proteomics. 2009
PubMed ID: 19131326
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.
Ouyang J, Shi Y, Valin A, Xuan Y, Gill G
Mol Cell. 2009
PubMed ID: 19394292
ATRX marks the inactive X chromosome (Xi) in somatic cells and during imprinted X chromosome inactivation in trophoblast stem cells.
Baumann C, De La Fuente R
Chromosoma. 2009
PubMed ID: 19005673
Cooperativity of Mus81.Mms4 with Rad54 in the resolution of recombination and replication intermediates.
Matulova P, Marini V, Burgess RC, Sisakova A, Kwon Y, Rothstein R, Sung P, Krejci L
J Biol Chem. 2009
PubMed ID: 19129197
Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome.
Medina CF, Mazerolle C, Wang Y, Bérubé NG, Coupland S, Gibbons RJ, Wallace VA, Picketts DJ
Hum Mol Genet. 2009
PubMed ID: 19088125
Loss of ATRX in chondrocytes has minimal effects on skeletal development.
Solomon LA, Li JR, Bérubé NG, Beier F
PLoS One. 2009
PubMed ID: 19774083
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Maternal diabetes alters transcriptional programs in the developing embryo.
Pavlinkova G, Salbaum JM, Kappen C
BMC Genomics. 2009
PubMed ID: 19538749
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
Common single-nucleotide polymorphisms in DNA double-strand break repair genes and breast cancer risk.
Pooley KA, Baynes C, Driver KE, Tyrer J, Azzato EM, Pharoah PD, Easton DF, Ponder BA, Dunning AM
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064565
Human cytomegalovirus protein pp71 displaces the chromatin-associated factor ATRX from nuclear domain 10 at early stages of infection.
Lukashchuk V, McFarlane S, Everett RD, Preston CM
J Virol. 2008
PubMed ID: 18922870
Human Rad54 protein stimulates human Mus81-Eme1 endonuclease.
Mazina OM, Mazin AV
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19017809
Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53.
Seah C, Levy MA, Jiang Y, Mokhtarzada S, Higgs DR, Gibbons RJ, Bérubé NG
J Neurosci. 2008
PubMed ID: 19020049
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Mutations in the chromatin-associated protein ATRX.
Gibbons RJ, Wada T, Fisher CA, Malik N, Mitson MJ, Steensma DP, Fryer A, Goudie DR, Krantz ID, Traeger-Synodinos J
Hum Mutat. 2008
PubMed ID: 18409179
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Patient mutations alter ATRX targeting to PML nuclear bodies.
Bérubé NG, Healy J, Medina CF, Wu S, Hodgson T, Jagla M, Picketts DJ
Eur J Hum Genet. 2008
PubMed ID: 17957225
Loss of ATRX leads to chromosome cohesion and congression defects.
Ritchie K, Seah C, Moulin J, Isaac C, Dick F, Bérubé NG
J Cell Biol. 2008
PubMed ID: 18227278
The SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome.
Levy MA, Fernandes AD, Tremblay DC, Seah C, Bérubé NG
BMC Genomics. 2008
PubMed ID: 18842153
Association of ATRX with pericentric heterochromatin and the Y chromosome of neonatal mouse spermatogonia.
Baumann C, Schmidtmann A, Muegge K, De La Fuente R
BMC Mol Biol. 2008
PubMed ID: 18366812
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD
J Proteome Res. 2007
PubMed ID: 17924679
Partial duplications of the ATRX gene cause the ATR-X syndrome.
Thienpont B, de Ravel T, Van Esch H, Van Schoubroeck D, Moerman P, Vermeesch JR, Fryns JP, Froyen G, Lacoste C, Badens C, Devriendt K
Eur J Hum Genet. 2007
PubMed ID: 17579672
Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.
Argentaro A, Yang JC, Chapman L, Kowalczyk MS, Gibbons RJ, Higgs DR, Neuhaus D, Rhodes D
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17609377
Defining the cause of skewed X-chromosome inactivation in X-linked mental retardation by use of a mouse model.
Muers MR, Sharpe JA, Garrick D, Sloane-Stanley J, Nolan PM, Hacker T, Wood WG, Higgs DR, Gibbons RJ
Am J Hum Genet. 2007
PubMed ID: 17503331
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ
Science. 2007
PubMed ID: 17525332
Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.
Nan X, Hou J, Maclean A, Nasir J, Lafuente MJ, Shu X, Kriaucionis S, Bird A
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17296936
Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.
Molina H, Horn DM, Tang N, Mathivanan S, Pandey A
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17287340
Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.
Dai J, Jin WH, Sheng QH, Shieh CH, Wu JR, Zeng R
J Proteome Res. 2007
PubMed ID: 17203969
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Otterlei M, Bruheim P, Ahn B, Bussen W, Karmakar P, Baynton K, Bohr VA
J Cell Sci. 2006
PubMed ID: 17118963
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
ATRX syndrome in a girl with a heterozygous mutation in the ATRX Zn finger domain and a totally skewed X-inactivation pattern.
Badens C, Martini N, Courrier S, DesPortes V, Touraine R, Levy N, Edery P
Am J Med Genet A. 2006
PubMed ID: 16955409
Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
Wang AG, Yoon SY, Oh JH, Jeon YJ, Kim M, Kim JM, Byun SS, Yang JO, Kim JH, Kim DG, Yeom YI, Yoo HS, Kim YS, Kim NS
Biochem Biophys Res Commun. 2006
PubMed ID: 16712791
A novel splicing mutation of the ATRX gene in ATR-X syndrome.
Wada T, Sakakibara M, Fukushima Y, Saitoh S
Brain Dev. 2006
PubMed ID: 16376512
A novel mutation in the last exon of ATRX in a patient with alpha-thalassemia myelodysplastic syndrome.
Costa DB, Fisher CA, Miller KB, Pihan GA, Steensma DP, Gibbons RJ, Higgs DR
Eur J Haematol. 2006
PubMed ID: 16480427
Comprehensive identification of phosphorylation sites in postsynaptic density preparations.
Trinidad JC, Specht CG, Thalhammer A, Schoepfer R, Burlingame AL
Mol Cell Proteomics. 2006
PubMed ID: 16452087
Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.
Garrick D, Sharpe JA, Arkell R, Dobbie L, Smith AJ, Wood WG, Higgs DR, Gibbons RJ
PLoS Genet. 2006
PubMed ID: 16628246
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
De novo and acquired forms of alpha thalassemia.
Forget BG
Curr Hematol Rep. 2006
PubMed ID: 16537041
Rad54: the Swiss Army knife of homologous recombination?
Heyer WD, Li X, Rolfsmeier M, Zhang XP
Nucleic Acids Res. 2006
PubMed ID: 16935872
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Asplenia in ATR-X syndrome: a second report.
Leahy RT, Philip RK, Gibbons RJ, Fisher C, Suri M, Reardon W
Am J Med Genet A. 2005
PubMed ID: 16222662
A novel 5' ATRX mutation with splicing consequences in acquired alpha thalassemia-myelodysplastic syndrome.
Nelson ME, Thurmes PJ, Hoyer JD, Steensma DP
Haematologica. 2005
PubMed ID: 16266892
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases.
Wang AH, Grégoire S, Zika E, Xiao L, Li CS, Li H, Wright KL, Ting JP, Yang XJ
J Biol Chem. 2005
PubMed ID: 15964851
The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain.
Lechner MS, Schultz DC, Negorev D, Maul GG, Rauscher FJ
Biochem Biophys Res Commun. 2005
PubMed ID: 15882967
Scanning the human proteome for calmodulin-binding proteins.
Shen X, Valencia CA, Szostak JW, Szostak J, Dong B, Liu R
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15840729
The DNA sequence of the human X chromosome.
Ross MT, Grafham DV, Coffey AJ, Scherer S, McLay K, Muzny D, Platzer M, Howell GR, Burrows C, Bird CP, Frankish A, Lovell FL, Howe KL, Ashurst JL, Fulton RS, Sudbrak R, Wen G, Jones MC, Hurles ME, Andrews TD, Scott CE, Searle S, Ramser J, Whittaker A, Deadman R, Carter NP, Hunt SE, Chen R, Cree A, Gunaratne P, Havlak P, Hodgson A, Metzker ML, Richards S, Scott G, Steffen D, Sodergren E, Wheeler DA, Worley KC, Ainscough R, Ambrose KD, Ansari-Lari MA, Aradhya S, Ashwell RI, Babbage AK, Bagguley CL, Ballabio A, Banerjee R, Barker GE, Barlow KF, Barrett IP, Bates KN, Beare DM, Beasley H, Beasley O, Beck A, Bethel G, Blechschmidt K, Brady N, Bray-Allen S, Bridgeman AM, Brown AJ, Brown MJ, Bonnin D, Bruford EA, Buhay C, Burch P, Burford D, Burgess J, Burrill W, Burton J, Bye JM, Carder C, Carrel L, Chako J, Chapman JC, Chavez D, Chen E, Chen G, Chen Y, Chen Z, Chinault C, Ciccodicola A, Clark SY, Clarke G, Clee CM, Clegg S, Clerc-Blankenburg K, Clifford K, Cobley V, Cole CG, Conquer JS, Corby N, Connor RE, David R, Davies J, Davis C, Davis J, Delgado O, Deshazo D, Dhami P, Ding Y, Dinh H, Dodsworth S, Draper H, Dugan-Rocha S, Dunham A, Dunn M, Durbin KJ, Dutta I, Eades T, Ellwood M, Emery-Cohen A, Errington H, Evans KL, Faulkner L, Francis F, Frankland J, Fraser AE, Galgoczy P, Gilbert J, Gill R, Glöckner G, Gregory SG, Gribble S, Griffiths C, Grocock R, Gu Y, Gwilliam R, Hamilton C, Hart EA, Hawes A, Heath PD, Heitmann K, Hennig S, Hernandez J, Hinzmann B, Ho S, Hoffs M, Howden PJ, Huckle EJ, Hume J, Hunt PJ, Hunt AR, Isherwood J, Jacob L, Johnson D, Jones S, de Jong PJ, Joseph SS, Keenan S, Kelly S, Kershaw JK, Khan Z, Kioschis P, Klages S, Knights AJ, Kosiura A, Kovar-Smith C, Laird GK, Langford C, Lawlor S, Leversha M, Lewis L, Liu W, Lloyd C, Lloyd DM, Loulseged H, Loveland JE, Lovell JD, Lozado R, Lu J, Lyne R, Ma J, Maheshwari M, Matthews LH, McDowall J, McLaren S, McMurray A, Meidl P, Meitinger T, Milne S, Miner G, Mistry SL, Morgan M, Morris S, Müller I, Mullikin JC, Nguyen N, Nordsiek G, Nyakatura G, O'Dell CN, Okwuonu G, Palmer S, Pandian R, Parker D, Parrish J, Pasternak S, Patel D, Pearce AV, Pearson DM, Pelan SE, Perez L, Porter KM, Ramsey Y, Reichwald K, Rhodes S, Ridler KA, Schlessinger D, Schueler MG, Sehra HK, Shaw-Smith C, Shen H, Sheridan EM, Shownkeen R, Skuce CD, Smith ML, Sotheran EC, Steingruber HE, Steward CA, Storey R, Swann RM, Swarbreck D, Tabor PE, Taudien S, Taylor T, Teague B, Thomas K, Thorpe A, Timms K, Tracey A, Trevanion S, Tromans AC, d'Urso M, Verduzco D, Villasana D, Waldron L, Wall M, Wang Q, Warren J, Warry GL, Wei X, West A, Whitehead SL, Whiteley MN, Wilkinson JE, Willey DL, Williams G, Williams L, Williamson A, Williamson H, Wilming L, Woodmansey RL, Wray PW, Yen J, Zhang J, Zhou J, Zoghbi H, Zorilla S, Buck D, Reinhardt R, Poustka A, Rosenthal A, Lehrach H, Meindl A, Minx PJ, Hillier LW, Willard HF, Wilson RK, Waterston RH, Rice CM, Vaudin M, Coulson A, Nelson DL, Weinstock G, Sulston JE, Durbin R, Hubbard T, Gibbs RA, Beck S, Rogers J, Bentley DR
Nature. 2005
PubMed ID: 15772651
The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis.
Bérubé NG, Mangelsdorf M, Jagla M, Vanderluit J, Garrick D, Gibbons RJ, Higgs DR, Slack RS, Picketts DJ
J Clin Invest. 2005
PubMed ID: 15668733
A missense mutation in the coiled-coil motif of the HP1-interacting domain of ATR-X in a family with X-linked mental retardation.
Wieland I, Sabathil J, Ostendorf A, Rittinger O, Röpke A, Winnepenninckx B, Kooy F, Holinski-Feder E, Wieacker P
Neurogenetics. 2005
PubMed ID: 15565397
Mutation in the 5' alternatively spliced region of the XNP/ATR-X gene causes Chudley-Lowry syndrome.
Abidi FE, Cardoso C, Lossi AM, Lowry RB, Depetris D, Mattéi MG, Lubs HA, Stevenson RE, Fontes M, Chudley AE, Schwartz CE
Eur J Hum Genet. 2005
PubMed ID: 15508018
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
Human Rad54 protein stimulates DNA strand exchange activity of hRad51 protein in the presence of Ca2+.
Mazina OM, Mazin AV
J Biol Chem. 2004
PubMed ID: 15466868
Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins.
Wang L, Zheng A, Yi L, Xu C, Ding M, Deng H
Biochem Biophys Res Commun. 2004
PubMed ID: 15522233
Attenuation of an amino-terminal premature stop codon mutation in the ATRX gene by an alternative mode of translational initiation.
Howard MT, Malik N, Anderson CB, Voskuil JL, Atkins JF, Gibbons RJ
J Med Genet. 2004
PubMed ID: 15591283
ATRX and sex differentiation.
Tang P, Park DJ, Marshall Graves JA, Harley VR
Trends Endocrinol Metab. 2004
PubMed ID: 15350606
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15302935
Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX.
Ishov AM, Vladimirova OV, Maul GG
J Cell Sci. 2004
PubMed ID: 15252119
ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes.
De La Fuente R, Viveiros MM, Wigglesworth K, Eppig JJ
Dev Biol. 2004
PubMed ID: 15242786
A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein.
Tang J, Wu S, Liu H, Stratt R, Barak OG, Shiekhattar R, Picketts DJ, Yang X
J Biol Chem. 2004
PubMed ID: 14990586
Acquired somatic ATRX mutations in myelodysplastic syndrome associated with alpha thalassemia (ATMDS) convey a more severe hematologic phenotype than germline ATRX mutations.
Steensma DP, Higgs DR, Fisher CA, Gibbons RJ
Blood. 2004
PubMed ID: 14592816
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis.
Zoltewicz JS, Stewart NJ, Leung R, Peterson AS
Development. 2004
PubMed ID: 14645126
Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.
Surpili MJ, Delben TM, Kobarg J
Biochemistry. 2003
PubMed ID: 14690447
Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.
Craig JM, Earle E, Canham P, Wong LH, Anderson M, Choo KH
Hum Mol Genet. 2003
PubMed ID: 14519686
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies.
Xue Y, Gibbons R, Yan Z, Yang D, McDowell TL, Sechi S, Qin J, Zhou S, Higgs D, Wang W
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12953102
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the alpha-thalassemia myelodysplasia syndrome (ATMDS).
Gibbons RJ, Pellagatti A, Garrick D, Wood WG, Malik N, Ayyub H, Langford C, Boultwood J, Wainscoat JS, Higgs DR
Nat Genet. 2003
PubMed ID: 12858175
Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees.
Kitano T, Schwarz C, Nickel B, Pääbo S
Mol Biol Evol. 2003
PubMed ID: 12777533
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Homologous DNA pairing by human recombination factors Rad51 and Rad54.
Sigurdsson S, Van Komen S, Petukhova G, Sung P
J Biol Chem. 2002
PubMed ID: 12205100
Expanding phenotype of XNP mutations: mild to moderate mental retardation.
Yntema HG, Poppelaars FA, Derksen E, Oudakker AR, van Roosmalen T, Jacobs A, Obbema H, Brunner HG, Hamel BC, van Bokhoven H
Am J Med Genet. 2002
PubMed ID: 12116232
Neurodevelopmental defects resulting from ATRX overexpression in transgenic mice.
Bérubé NG, Jagla M, Smeenk C, De Repentigny Y, Kothary R, Picketts DJ
Hum Mol Genet. 2002
PubMed ID: 11823444
Large-scale identification of mammalian proteins localized to nuclear sub-compartments.
Sutherland HG, Mumford GK, Newton K, Ford LV, Farrall R, Dellaire G, Cáceres JF, Bickmore WA
Hum Mol Genet. 2001
PubMed ID: 11555636
Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Piao Y, Ko NT, Lim MK, Ko MS
Genome Res. 2001
PubMed ID: 11544199
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Holmes-Gang syndrome is allelic with XLMR-hypotonic face syndrome.
Stevenson RE, Abidi F, Schwartz CE, Lubs HA, Holmes LB
Am J Med Genet. 2000
PubMed ID: 11050622
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Molecular genetic study of japanese patients with X-linked alpha-thalassemia/mental retardation syndrome (ATR-X).
Wada T, Kubota T, Fukushima Y, Saitoh S
Am J Med Genet. 2000
PubMed ID: 10995512
A novel human rad54 homologue, Rad54B, associates with Rad51.
Tanaka K, Hiramoto T, Fukuda T, Miyagawa K
J Biol Chem. 2000
PubMed ID: 10851248
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange.
Dronkert ML, Beverloo HB, Johnson RD, Hoeijmakers JH, Jasin M, Kanaar R
Mol Cell Biol. 2000
PubMed ID: 10757799
Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation.
Gibbons RJ, McDowell TL, Raman S, O'Rourke DM, Garrick D, Ayyub H, Higgs DR
Nat Genet. 2000
PubMed ID: 10742099
Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10737800
Identification of a mutation in the XNP/ATR-X gene in a family reported as Smith-Fineman-Myers syndrome.
Villard L, Fontès M, Adès LC, Gecz J
Am J Med Genet. 2000
PubMed ID: 10751095
Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin association.
Bérubé NG, Smeenk CA, Picketts DJ
Hum Mol Genet. 2000
PubMed ID: 10699177
Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes.
McDowell TL, Gibbons RJ, Sutherland H, O'Rourke DM, Bickmore WA, Pombo A, Turley H, Gatter K, Picketts DJ, Buckle VJ, Chapman L, Rhodes D, Higgs DR
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10570185
Mutation of the XNP/ATR-X gene in a family with severe mental retardation, spastic paraplegia and skewed pattern of X inactivation: demonstration that the mutation is involved in the inactivation bias.
Lossi AM, Millán JM, Villard L, Orellana C, Cardoso C, Prieto F, Fontés M, Martínez F
Am J Hum Genet. 1999
PubMed ID: 10417298
Carpenter-Waziri syndrome results from a mutation in XNP.
Abidi F, Schwartz CE, Carpenter NJ, Villard L, Fontés M, Curtis M
Am J Med Genet. 1999
PubMed ID: 10398237
Evaluation of a mutation screening strategy for sporadic cases of ATR-X syndrome.
Villard L, Bonino MC, Abidi F, Ragusa A, Belougne J, Lossi AM, Seaver L, Bonnefont JP, Romano C, Fichera M, Lacombe D, Hanauer A, Philip N, Schwartz C, Fontés M
J Med Genet. 1999
PubMed ID: 10204841
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells.
Takata M, Sasaki MS, Sonoda E, Morrison C, Hashimoto M, Utsumi H, Yamaguchi-Iwai Y, Shinohara A, Takeda S
EMBO J. 1998
PubMed ID: 9736627
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice.
Jacobs H, Fukita Y, van der Horst GT, de Boer J, Weeda G, Essers J, de Wind N, Engelward BP, Samson L, Verbeek S, de Murcia JM, de Murcia G, te Riele H, Rajewsky K
J Exp Med. 1998
PubMed ID: 9607915
Comparison of the human and murine ATRX gene identifies highly conserved, functionally important domains.
Picketts DJ, Tastan AO, Higgs DR, Gibbons RJ
Mamm Genome. 1998
PubMed ID: 9545503
Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein.
Cardoso C, Timsit S, Villard L, Khrestchatisky M, Fontès M, Colleaux L
Hum Mol Genet. 1998
PubMed ID: 9499421
New mutations in XNP/ATR-X gene: a further contribution to genotype/phenotype relationship in ATR/X syndrome. Mutations in brief no. 176. Online.
Fichera M, Romano C, Castiglia L, Failla P, Ruberto C, Amata S, Greco D, Cardoso C, Fontés M, Ragusa A
Hum Mutat. 1998
PubMed ID: 10660327
Interaction of human recombination proteins Rad51 and Rad54.
Golub EI, Kovalenko OV, Gupta RC, Ward DC, Radding CM
Nucleic Acids Res. 1997
PubMed ID: 9321665
Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain.
Gibbons RJ, Bachoo S, Picketts DJ, Aftimos S, Asenbauer B, Bergoffen J, Berry SA, Dahl N, Fryer A, Keppler K, Kurosawa K, Levin ML, Masuno M, Neri G, Pierpont ME, Slaney SF, Higgs DR
Nat Genet. 1997
PubMed ID: 9326931
Determination of the genomic structure of the XNP/ATRX gene encoding a potential zinc finger helicase.
Villard L, Lossi AM, Cardoso C, Proud V, Chiaroni P, Colleaux L, Schwartz C, Fontés M
Genomics. 1997
PubMed ID: 9244431
A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.
Le Douarin B, Nielsen AL, Garnier JM, Ichinose H, Jeanmougin F, Losson R, Chambon P
EMBO J. 1996
PubMed ID: 8978696
ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome.
Picketts DJ, Higgs DR, Bachoo S, Blake DJ, Quarrell OW, Gibbons RJ
Hum Mol Genet. 1996
PubMed ID: 8968741
Genomic organization of the mottled gene, the mouse homologue of the human Menkes disease gene.
Cecchi C, Avner P
Genomics. 1996
PubMed ID: 8921375
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Molecular cloning and characterization of annexin V-binding proteins with highly hydrophilic peptide structure.
Ohsawa K, Imai Y, Ito D, Kohsaka S
J Neurochem. 1996
PubMed ID: 8667030
XNP mutation in a large family with Juberg-Marsidi syndrome.
Villard L, Gecz J, Mattéi JF, Fontés M, Saugier-Veber P, Munnich A, Lyonnet S
Nat Genet. 1996
PubMed ID: 8630485
A point mutation in the XNP gene, associated with an ATR-X phenotype without alpha-thalassemia.
Villard L, Lacombe D, Fontés M
Eur J Hum Genet. 1996
PubMed ID: 9043863
Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome).
Gibbons RJ, Picketts DJ, Villard L, Higgs DR
Cell. 1995
PubMed ID: 7697714
Cloning and characterization of a new human Xq13 gene, encoding a putative helicase.
Stayton CL, Dabovic B, Gulisano M, Gecz J, Broccoli V, Giovanazzi S, Bossolasco M, Monaco L, Rastan S, Boncinelli E
Hum Mol Genet. 1994
PubMed ID: 7874112
Integration of gene maps: chromosome X.
Wang LH, Collins A, Lawrence S, Keats BJ, Morton NE
Genomics. 1994
PubMed ID: 8001970
Cloning and expression of the murine homologue of a putative human X-linked nuclear protein gene closely linked to PGK1 in Xq13.3.
Gecz J, Pollard H, Consalez G, Villard L, Stayton C, Millasseau P, Khrestchatisky M, Fontes M
Hum Mol Genet. 1994
PubMed ID: 8162050
Physical and transcriptional mapping of DXS56-PGK1 1 Mb region: identification of three new transcripts.
Gecz J, Villard L, Lossi AM, Millasseau P, Djabali M, Fontes M
Hum Mol Genet. 1993
PubMed ID: 8242062
The Juberg-Marsidi syndrome maps to the proximal long arm of the X chromosome (Xq12-q21).
Saugier-Veber P, Abadie V, Moncla A, Mathieu M, Piussan C, Turleau C, Mattei JF, Munnich A, Lyonnet S
Am J Hum Genet. 1993
PubMed ID: 8503439
X-linked alpha-thalassemia/mental retardation (ATR-X) syndrome: localization to Xq12-q21.31 by X inactivation and linkage analysis.
Gibbons RJ, Suthers GK, Wilkie AO, Buckle VJ, Higgs DR
Am J Hum Genet. 1992
PubMed ID: 1415255
Nomenclature guidelines for X-linked mental retardation.
Mulley JC, Kerr B, Stevenson R, Lubs H
Am J Med Genet. 1992
PubMed ID: 1605216
Smith-Fineman-Myers syndrome in two brothers.
Adès LC, Kerr B, Turner G, Wise G
Am J Med Genet. 1991
PubMed ID: 1684092
Linkage studies with the gene for an X-linked syndrome of mental retardation, microcephaly and spastic diplegia (MRX2)
Sutherland GR, Gedeon AK, Haan EA, Woodroffe P, Mulley JC
Am J Med Genet. 1988
PubMed ID: 3177467
RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression.
Shapiro MB, Senapathy P
Nucleic Acids Res. 1987
PubMed ID: 3658675
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Model Organism Phenotype Links from MGI Top Help

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	Human	Mouse	Rat
Entrez Gene	546	22589	246284
EnsEMBL Gene(s)	ENSG00000085224	ENSMUSG00000031229	N/A
Unigene	Hs.533526	Mm.10141	Rn.226151
Homologene	ATRX	Atrx	Atrx
OMIM	300032	N/A	N/A
GeneCards	ATRX	N/A	N/A
Beta Cell Genomics	DT.100736904 DT.100797559 DT.121314392 DT.121314448 DT.75188922 DT.95207537 DT.95207550 DT.99950475	DT.40153305 DT.55280069 DT.94313206 DT.97344752	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	546	22589	246284

External resources from NIDDK Consortium Interconnectivity Network Top Help

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Interactor	Interactor	Sources	Classification	Pubmed IDs
ATRX	DAXX	HPRD, IntAct	empirical	12953102
ATRX	ATN1	HPRD	empirical	14645126
ATRX	EIF4A2	IntAct	empirical	17353931
ATRX	EZH2	HPRD	empirical	9499421
ATRX	HDAC1	HPRD	empirical	14645126
ATRX	ANXA5	IntAct	empirical	8667030
ATRX	NEK1	HPRD, IntAct	empirical	14690447
ATRX	LUC7L2	HPRD, IntAct	empirical	16169070
ATRX	FAM190B	HPRD, IntAct	empirical	16169070
ATRX	ZNF512B	MINT	empirical	15231748
ATRX	KIAA1377	HPRD, IntAct	empirical	16169070
ATRX	PTN	HPRD, IntAct	empirical	16169070
ATRX	PTPN4	HPRD, IntAct	empirical	16169070
ATRX	RAD51	HPRD	empirical	9321665
ATRX	HDAC4	HPRD	empirical	15964851