PML

Summary Top Help

Gene Description:

promyelocytic leukemia

Synonyms:

PML, Trim19, PP8675, AI661194, Pml, RNF71, RGD1562602, TRIM19, MYL, 1200009E24Rik

Orthologs:

Human PML (protein-coding), Mouse Pml (protein-coding), Rat Pml (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd2	Mouse	chr9:32308040..98698811	66.39	764	6 no lod score

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr15:74287014..74340160 (53.15 kb) View in Genome Browser

(Mouse) NCBIM37 - chr9:58064986..58097593 (32.61 kb) View in Genome Browser

(Rat) RGSC3.4 - chr8:62020438..62051927 (31.49 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PML:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
								no data	no data	no data	no data	no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PML:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 5

Biocarta: 1

Reactome: None available

NCI-Nature Pathway Interaction Database: 5

Gene Ontology: 69

Response to hypoxia	GO:0001666
Regulation of protein phosphorylation	GO:0001932
Positive regulation of defense response to virus by host	GO:0002230
DNA binding	GO:0003677
Transcription coactivator activity	GO:0003713
Protein binding	GO:0005515
Intracellular	GO:0005622
Insoluble fraction	GO:0005626
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Nucleolus	GO:0005730
Cytoplasm	GO:0005737
Endosome	GO:0005768
Endoplasmic reticulum	GO:0005783
Cytosol	GO:0005829
Protein complex assembly	GO:0006461
Protein targeting	GO:0006605
Induction of apoptosis	GO:0006917
Activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0006919
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977
Cell cycle arrest	GO:0007050
Transforming growth factor beta receptor signaling pathway	GO:0007179
Common-partner SMAD protein phosphorylation	GO:0007182
SMAD protein import into nucleus	GO:0007184
Cell aging	GO:0007569
Zinc ion binding	GO:0008270
Negative regulation of cell proliferation	GO:0008285
DNA damage response, signal transduction resulting in induction of apoptosis	GO:0008630
Response to UV	GO:0009411
Response to virus	GO:0009615
Response to gamma radiation	GO:0010332
Regulation of calcium ion transport into cytosol	GO:0010522
Membrane	GO:0016020
Nuclear matrix	GO:0016363
Negative regulation of angiogenesis	GO:0016525
PML body	GO:0016605
Cytokine-mediated signaling pathway	GO:0019221
Myeloid cell differentiation	GO:0030099
Negative regulation of cell growth	GO:0030308
PML body organization	GO:0030578
Positive regulation of histone deacetylation	GO:0031065
Ubiquitin protein ligase binding	GO:0031625
Early endosome membrane	GO:0031901
Nuclear membrane	GO:0031965
SUMO binding	GO:0032183
Negative regulation of telomere maintenance via telomerase	GO:0032211
Endoplasmic reticulum calcium ion homeostasis	GO:0032469
Negative regulation of translation in response to oxidative stress	GO:0032938
Response to cytokine stimulus	GO:0034097
Extrinsic to endoplasmic reticulum membrane	GO:0042406
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	GO:0042771
Protein homodimerization activity	GO:0042803
Interspecies interaction between organisms	GO:0044419
Cell fate commitment	GO:0045165
Regulation of MHC class I biosynthetic process	GO:0045343
Negative regulation of transcription, DNA-dependent	GO:0045892
Negative regulation of mitotic cell cycle	GO:0045930
SMAD binding	GO:0046332
Metal ion binding	GO:0046872
Protein heterodimerization activity	GO:0046982
Retinoic acid receptor signaling pathway	GO:0048384
Protein stabilization	GO:0050821
Cobalt ion binding	GO:0050897
Maintenance of protein location in nucleus	GO:0051457
Negative regulation of telomerase activity	GO:0051974
Interferon-gamma-mediated signaling pathway	GO:0060333
Branching involved in mammary gland duct morphogenesis	GO:0060444
Negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	GO:2000059
Positive regulation of extrinsic apoptotic signaling pathway	GO:2001238

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 397

Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics.
Yang W, Thompson JW, Wang Z, Wang L, Sheng H, Foster MW, Moseley MA, Paschen W
J Proteome Res. 2012
PubMed ID: 22082260
MPL immunohistochemical expression as a novel marker for essential thrombocythemia and primary myelofibrosis differential diagnosis.
Ponce CC, Chauffaille Mde L, Ihara SS, Silva MR
Leuk Res. 2012
PubMed ID: 21752469
Promyelocytic leukemia isoform IV confers resistance to encephalomyocarditis virus via the sequestration of 3D polymerase in nuclear bodies.
Maroui MA, Pampin M, Chelbi-Alix MK
J Virol. 2011
PubMed ID: 21994459
Promyelocytic leukemia inhibits adipogenesis, and loss of promyelocytic leukemia results in fat accumulation in mice.
Kim MK, Yang S, Lee KH, Um JH, Liu M, Kang H, Park SJ, Chung JH
Am J Physiol Endocrinol Metab. 2011
PubMed ID: 21846906
General blockade of human cytomegalovirus immediate-early mRNA expression in the S/G2 phase by a nuclear, Daxx- and PML-independent mechanism.
Zydek M, Uecker R, Tavalai N, Stamminger T, Hagemeier C, Wiebusch L
J Gen Virol. 2011
PubMed ID: 21832009
Dual functions of histone-lysine N-methyltransferase Setdb1 protein at promyelocytic leukemia-nuclear body (PML-NB): maintaining PML-NB structure and regulating the expression of its associated genes.
Cho S, Park JS, Kang YK
J Biol Chem. 2011
PubMed ID: 21921037
PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo.
Tao RH, Berkova Z, Wise JF, Rezaeian AH, Daniluk U, Ao X, Hawke DH, Karp JE, Lin HK, Molldrem JJ, Samaniego F
Blood. 2011
PubMed ID: 21803845
Exome sequencing supports a de novo mutational paradigm for schizophrenia.
Xu B, Roos JL, Dexheimer P, Boone B, Plummer B, Levy S, Gogos JA, Karayiorgou M
Nat Genet. 2011
PubMed ID: 21822266
A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression.
Yuan WC, Lee YR, Huang SF, Lin YM, Chen TY, Chung HC, Tsai CH, Chen HY, Chiang CT, Lai CK, Lu LT, Chen CH, Gu DL, Pu YS, Jou YS, Lu KP, Hsiao PW, Shih HM, Chen RH
Cancer Cell. 2011
PubMed ID: 21840486
Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment.
Goto E, Tomita A, Hayakawa F, Atsumi A, Kiyoi H, Naoe T
Blood. 2011
PubMed ID: 21613260
A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway.
Zheng Y, Qin H, Frank SJ, Deng L, Litchfield DW, Tefferi A, Pardanani A, Lin FT, Li J, Sha B, Benveniste EN
Blood. 2011
PubMed ID: 21527517
SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes.
Cuchet-Lourenço D, Boutell C, Lukashchuk V, Grant K, Sykes A, Murray J, Orr A, Everett RD
PLoS Pathog. 2011
PubMed ID: 21779164
A novel PML-ADAMTS17-RARA gene rearrangement in a patient with pregnancy-related acute promyelocytic leukemia.
Lim G, Cho EH, Cho SY, Shin SY, Park JC, Yang YJ, Oh SH, Marschalek R, Meyer C, Park TS
Leuk Res. 2011
PubMed ID: 21529941
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Nuclear body formation and PML body remodeling by the human cytomegalovirus protein UL35.
Salsman J, Wang X, Frappier L
Virology. 2011
PubMed ID: 21489587
The alphaherpesvirus serine/threonine kinase us3 disrupts promyelocytic leukemia protein nuclear bodies.
Jung M, Finnen RL, Neron CE, Banfield BW
J Virol. 2011
PubMed ID: 21430051
PML protein as a prognostic molecular marker for patients with esophageal squamous cell carcinomas receiving primary surgery.
Yen CC, Tsao YP, Chen PC, Wu YC, Liu JH, Pan CC, Liu CY, Tzeng CH, Chen PM, Chen YJ, Lin CH, Hsu WH
J Surg Oncol. 2011
PubMed ID: 21240990
Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.
the Genetic Determinants of Paget's Disease (GDPD) Consortium, Albagha OM, Wani SE, Visconti MR, Alonso N, Goodman K, Brandi ML, Cundy T, Chung PY, Dargie R, Devogelaer JP, Falchetti A, Fraser WD, Gennari L, Gianfrancesco F, Hooper MJ, Van Hul W, Isaia G, Nicholson GC, Nuti R, Papapoulos S, Montes JD, Ratajczak T, Rea SL, Rendina D, Gonzalez-Sarmiento R, Di Stefano M, Ward LC, Walsh JP, Ralston SH
Nat Genet. 2011
PubMed ID: 21623375
Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in γ-irradiation-induced DNA damage responses.
Liu J, Song Y, Qian J, Liu B, Dong Y, Tian B, Sun Z
Biochemistry (Mosc). 2011
PubMed ID: 21639834
Pml represses tumour progression through inhibition of mTOR.
Bernardi R, Papa A, Egia A, Coltella N, Teruya-Feldstein J, Signoretti S, Pandolfi PP
EMBO Mol Med. 2011
PubMed ID: 21387562
Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53.
Sung KS, Lee YA, Kim ET, Lee SR, Ahn JH, Choi CY
Exp Cell Res. 2011
PubMed ID: 21192925
Regulation of S100A10 by the PML-RAR-α oncoprotein.
O'Connell PA, Madureira PA, Berman JN, Liwski RS, Waisman DM
Blood. 2011
PubMed ID: 21310922
PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML.
Kurahashi S, Hayakawa F, Miyata Y, Yasuda T, Minami Y, Tsuzuki S, Abe A, Naoe T
Oncogene. 2011
PubMed ID: 21217775
PML is a key component for the differentiation of myeloid progenitor cells to macrophages.
Khalfin-Rabinovich Y, Weinstein A, Levi BZ
Int Immunol. 2011
PubMed ID: 21427174
PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.
Welch JS, Yuan W, Ley TJ
J Clin Invest. 2011
PubMed ID: 21364283
Promyelocytic leukemia protein in retinoic acid-induced chromatin remodeling of Oct4 gene promoter.
Chuang YS, Huang WH, Park SW, Persaud SD, Hung CH, Ho PC, Wei LN
Stem Cells. 2011
PubMed ID: 21360626
Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARα oncoprotein.
Wang Z, Cao L, Kang R, Yang M, Liu L, Zhao Y, Yu Y, Xie M, Yin X, Livesey KM, Tang D
Autophagy. 2011
PubMed ID: 21187718
The role of PML in the nervous system.
Salomoni P, Betts-Henderson J
Mol Neurobiol. 2011
PubMed ID: 21161613
AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation.
Li Q, He Y, Wei L, Wu X, Wu D, Lin S, Wang Z, Ye Z, Lin SC
Oncogene. 2011
PubMed ID: 21057547
SUMO E3 ligase activity of TRIM proteins.
Chu Y, Yang X
Oncogene. 2011
PubMed ID: 20972456
PML positively regulates interferon gamma signaling.
El Bougrini J, Dianoux L, Chelbi-Alix MK
Biochimie. 2011
PubMed ID: 21115099
The reduced and altered activities of PAX5 are linked to the protein-protein interaction motif (coiled-coil domain) of the PAX5-PML fusion protein in t(9;15)-associated acute lymphocytic leukemia.
Qiu JJ, Chu H, Lu X, Jiang X, Dong S
Oncogene. 2011
PubMed ID: 20972455
Genome-wide functions of PML-RARα in acute promyelocytic leukaemia.
Saeed S, Logie C, Stunnenberg HG, Martens JH
Br J Cancer. 2011
PubMed ID: 21245861
PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication.
Cuchet D, Sykes A, Nicolas A, Orr A, Murray J, Sirma H, Heeren J, Bartelt A, Everett RD
J Cell Sci. 2011
PubMed ID: 21172801
Loss of the promyelocytic leukemia protein in gastric cancer: implications for IP-10 expression and tumor-infiltrating lymphocytes.
Kim HJ, Song DE, Lim SY, Lee SH, Kang JL, Lee SJ, Benveniste EN, Choi YH
PLoS One. 2011
PubMed ID: 22022583
Functional connection between Rad51 and PML in homology-directed repair.
Boichuk S, Hu L, Makielski K, Pandolfi PP, Gjoerup OV
PLoS One. 2011
PubMed ID: 21998700
The PML gene of the PML-RARα V-form fusion transcript breaks within exon 6.
Qi X, Tan Y, Chen X, Bian S, Zhang L, Xu A, Xu Z, Wang H
Acta Haematol. 2011
PubMed ID: 21934296
The herpesvirus associated ubiquitin specific protease, USP7, is a negative regulator of PML proteins and PML nuclear bodies.
Sarkari F, Wang X, Nguyen T, Frappier L
PLoS One. 2011
PubMed ID: 21305000
Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus.
Reichelt M, Wang L, Sommer M, Perrino J, Nour AM, Sen N, Baiker A, Zerboni L, Arvin AM
PLoS Pathog. 2011
PubMed ID: 21304940
Functional reorganization of promyelocytic leukemia nuclear bodies during BK virus infection.
Jiang M, Entezami P, Gamez M, Stamminger T, Imperiale MJ
MBio. 2011
PubMed ID: 21304169
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Regulation of E2Fs and senescence by PML nuclear bodies.
Vernier M, Bourdeau V, Gaumont-Leclerc MF, Moiseeva O, Bégin V, Saad F, Mes-Masson AM, Ferbeyre G
Genes Dev. 2011
PubMed ID: 21205865
Role of promyelocytic leukemia protein in host antiviral defense.
Geoffroy MC, Chelbi-Alix MK
J Interferon Cytokine Res. 2011
PubMed ID: 21198351
The SUMO protease SENP6 is a direct regulator of PML nuclear bodies.
Hattersley N, Shen L, Jaffray EG, Hay RT
Mol Biol Cell. 2011
PubMed ID: 21148299
Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.
Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL
Gene Expr Patterns. 2011
PubMed ID: 20932939
Investigation of genetic susceptibility factors for human longevity - A targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A
Mutat Res. 2010
PubMed ID: 20800603
Telomerase suppression initiates PML-dependent p53 activation to inhibit bladder cancer cell growth.
Xue Y, Li L, Zhang D, Wu K, Guo P, Zeng J, Wang X, He D
Oncol Rep. 2010
PubMed ID: 21042751
Pilocytic astrocytomas have telomere-associated promyelocytic leukemia bodies without alternatively lengthened telomeres.
Slatter T, Gifford-Garner J, Wiles A, Tan X, Chen YJ, MacFarlane M, Sullivan M, Royds J, Hung N
Am J Pathol. 2010
PubMed ID: 21037079
Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies.
Geoffroy MC, Jaffray EG, Walker KJ, Hay RT
Mol Biol Cell. 2010
PubMed ID: 20943951
PML regulates apoptosis at endoplasmic reticulum by modulating calcium release.
Giorgi C, Ito K, Lin HK, Santangelo C, Wieckowski MR, Lebiedzinska M, Bononi A, Bonora M, Duszynski J, Bernardi R, Rizzuto R, Tacchetti C, Pinton P, Pandolfi PP
Science. 2010
PubMed ID: 21030605
Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity.
Abbas HA, Maccio DR, Coskun S, Jackson JG, Hazen AL, Sills TM, You MJ, Hirschi KK, Lozano G
Cell Stem Cell. 2010
PubMed ID: 21040902
PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia.
Subramanyam D, Belair CD, Barry-Holson KQ, Lin H, Kogan SC, Passegué E, Blelloch R
Cancer Res. 2010
PubMed ID: 20861188
SUMOylation promotes PML degradation during encephalomyocarditis virus infection.
El McHichi B, Regad T, Maroui MA, Rodriguez MS, Aminev A, Gerbaud S, Escriou N, Dianoux L, Chelbi-Alix MK
J Virol. 2010
PubMed ID: 20826694
Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodies.
Sivachandran N, Cao JY, Frappier L
J Virol. 2010
PubMed ID: 20719947
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segrè AV, Speliotes EK, Wheeler E, Soranzo N, Park JH, Yang J, Gudbjartsson D, Heard-Costa NL, Randall JC, Qi L, Vernon Smith A, Mägi R, Pastinen T, Liang L, Heid IM, Luan J, Thorleifsson G, Winkler TW, Goddard ME, Sin Lo K, Palmer C, Workalemahu T, Aulchenko YS, Johansson A, Zillikens MC, Feitosa MF, Esko T, Johnson T, Ketkar S, Kraft P, Mangino M, Prokopenko I, Absher D, Albrecht E, Ernst F, Glazer NL, Hayward C, Hottenga JJ, Jacobs KB, Knowles JW, Kutalik Z, Monda KL, Polasek O, Preuss M, Rayner NW, Robertson NR, Steinthorsdottir V, Tyrer JP, Voight BF, Wiklund F, Xu J, Zhao JH, Nyholt DR, Pellikka N, Perola M, Perry JR, Surakka I, Tammesoo ML, Altmaier EL, Amin N, Aspelund T, Bhangale T, Boucher G, Chasman DI, Chen C, Coin L, Cooper MN, Dixon AL, Gibson Q, Grundberg E, Hao K, Juhani Junttila M, Kaplan LM, Kettunen J, König IR, Kwan T, Lawrence RW, Levinson DF, Lorentzon M, McKnight B, Morris AP, Müller M, Suh Ngwa J, Purcell S, Rafelt S, Salem RM, Salvi E, Sanna S, Shi J, Sovio U, Thompson JR, Turchin MC, Vandenput L, Verlaan DJ, Vitart V, White CC, Ziegler A, Almgren P, Balmforth AJ, Campbell H, Citterio L, De Grandi A, Dominiczak A, Duan J, Elliott P, Elosua R, Eriksson JG, Freimer NB, Geus EJ, Glorioso N, Haiqing S, Hartikainen AL, Havulinna AS, Hicks AA, Hui J, Igl W, Illig T, Jula A, Kajantie E, Kilpeläinen TO, Koiranen M, Kolcic I, Koskinen S, Kovacs P, Laitinen J, Liu J, Lokki ML, Marusic A, Maschio A, Meitinger T, Mulas A, Paré G, Parker AN, Peden JF, Petersmann A, Pichler I, Pietiläinen KH, Pouta A, Ridderstråle M, Rotter JI, Sambrook JG, Sanders AR, Schmidt CO, Sinisalo J, Smit JH, Stringham HM, Bragi Walters G, Widen E, Wild SH, Willemsen G, Zagato L, Zgaga L, Zitting P, Alavere H, Farrall M, McArdle WL, Nelis M, Peters MJ, Ripatti S, van Meurs JB, Aben KK, Ardlie KG, Beckmann JS, Beilby JP, Bergman RN, Bergmann S, Collins FS, Cusi D, den Heijer M, Eiriksdottir G, Gejman PV, Hall AS, Hamsten A, Huikuri HV, Iribarren C, Kähönen M, Kaprio J, Kathiresan S, Kiemeney L, Kocher T, Launer LJ, Lehtimäki T, Melander O, Mosley TH, Musk AW, Nieminen MS, O'Donnell CJ, Ohlsson C, Oostra B, Palmer LJ, Raitakari O, Ridker PM, Rioux JD, Rissanen A, Rivolta C, Schunkert H, Shuldiner AR, Siscovick DS, Stumvoll M, Tönjes A, Tuomilehto J, van Ommen GJ, Viikari J, Heath AC, Martin NG, Montgomery GW, Province MA, Kayser M, Arnold AM, Atwood LD, Boerwinkle E, Chanock SJ, Deloukas P, Gieger C, Grönberg H, Hall P, Hattersley AT, Hengstenberg C, Hoffman W, Lathrop GM, Salomaa V, Schreiber S, Uda M, Waterworth D, Wright AF, Assimes TL, Barroso I, Hofman A, Mohlke KL, Boomsma DI, Caulfield MJ, Cupples LA, Erdmann J, Fox CS, Gudnason V, Gyllensten U, Harris TB, Hayes RB, Jarvelin MR, Mooser V, Munroe PB, Ouwehand WH, Penninx BW, Pramstaller PP, Quertermous T, Rudan I, Samani NJ, Spector TD, Völzke H, Watkins H, Wilson JF, Groop LC, Haritunians T, Hu FB, Kaplan RC, Metspalu A, North KE, Schlessinger D, Wareham NJ, Hunter DJ, O'Connell JR, Strachan DP, Wichmann HE, Borecki IB, van Duijn CM, Schadt EE, Thorsteinsdottir U, Peltonen L, Uitterlinden AG, Visscher PM, Chatterjee N, Loos RJ, Boehnke M, McCarthy MI, Ingelsson E, Lindgren CM, Abecasis GR, Stefansson K, Frayling TM, Hirschhorn JN
Nature. 2010
PubMed ID: 20881960
SUMO modification of E1B-55K oncoprotein regulates isoform-specific binding to the tumour suppressor protein PML.
Wimmer P, Schreiner S, Everett RD, Sirma H, Groitl P, Dobner T
Oncogene. 2010
PubMed ID: 20639899
Resistance to rabies virus infection conferred by the PMLIV isoform.
Blondel D, Kheddache S, Lahaye X, Dianoux L, Chelbi-Alix MK
J Virol. 2010
PubMed ID: 20702643
Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein.
Isakson P, Bjørås M, Bøe SO, Simonsen A
Blood. 2010
PubMed ID: 20574048
PML down-regulation in soft tissue sarcomas.
Vincenzi B, Perrone G, Santini D, Grosso F, Silletta M, Frezza A, Rossi S, Russo A, Rabitti C, Gebbia N, Badalamenti G, Casali P, Muda AO, Dei Tos AP, Tonini G
J Cell Physiol. 2010
PubMed ID: 20578240
Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling.
Hubackova S, Novakova Z, Krejcikova K, Kosar M, Dobrovolna J, Duskova P, Hanzlikova H, Vancurova M, Barath P, Bartek J, Hodny Z
Cell Cycle. 2010
PubMed ID: 20699642
Analysis of t(15;17) chromosomal breakpoint sequences in therapy-related versus de novo acute promyelocytic leukemia: association of DNA breaks with specific DNA motifs at PML and RARA loci.
Hasan SK, Ottone T, Schlenk RF, Xiao Y, Wiemels JL, Mitra ME, Bernasconi P, Di Raimondo F, Stanghellini MT, Marco P, Mays AN, Döhner H, Sanz MA, Amadori S, Grimwade D, Lo-Coco F
Genes Chromosomes Cancer. 2010
PubMed ID: 20544846
PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3.
Jeanne M, Lallemand-Breitenbach V, Ferhi O, Koken M, Le Bras M, Duffort S, Peres L, Berthier C, Soilihi H, Raught B, de Thé H
Cancer Cell. 2010
PubMed ID: 20609355
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
Two-step colocalization of MORC3 with PML nuclear bodies.
Mimura Y, Takahashi K, Kawata K, Akazawa T, Inoue N
J Cell Sci. 2010
PubMed ID: 20501696
Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model.
Agrawal-Singh S, Koschmieder S, Gelsing S, Stocking C, Stehling M, Thiede C, Thoennissen NH, Köhler G, Valk PJ, Delwel R, Mills K, Bäumer N, Tickenbrock L, Hansen K, Berdel WE, Müller-Tidow C, Serve H
Blood. 2010
PubMed ID: 20215640
Modulation of the Zac1's transactivation and coactivation functions via PML and Daxx within distinct subcellular localizations.
Ho CL, Huang YC, Tai CK, Liu ST, Wang JK, Wang WM, Huang SM
Int J Biochem Cell Biol. 2010
PubMed ID: 20097304
Expression patterns of specific promyelocytic/retinoic acid receptor-alpha transcripts in patients with acute promyelocytic leukemia.
Lin J, Han LX, Qian J, Wang YL, Yao DM, Qian Z, Yang XF, Sheng XJ
Int J Lab Hematol. 2010
PubMed ID: 19863682
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses.
Lee YR, Yuan WC, Ho HC, Chen CH, Shih HM, Chen RH
EMBO J. 2010
PubMed ID: 20389280
Atypical mRNA fusions in PML-RARA positive, RARA-PML negative acute promyelocytic leukemia.
Walz C, Grimwade D, Saussele S, Lengfelder E, Haferlach C, Schnittger S, Lafage-Pochitaloff M, Hochhaus A, Cross NC, Reiter A
Genes Chromosomes Cancer. 2010
PubMed ID: 20155840
Long FLT3 internal tandem duplications and reduced PML-RARα expression at diagnosis characterize a high-risk subgroup of acute promyelocytic leukemia patients.
Chillón MC, Santamaría C, García-Sanz R, Balanzategui A, Sarasquete ME, Alcoceba M, Marín L, Caballero MD, Vidriales MB, Ramos F, Bernal T, Díaz-Mediavilla J, García de Coca A, Peñarrubia MJ, Queizán JA, Giraldo P, San Miguel JF, González M
Haematologica. 2010
PubMed ID: 20133893
SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress.
Han Y, Huang C, Sun X, Xiang B, Wang M, Yeh ET, Chen Y, Li H, Shi G, Cang H, Sun Y, Wang J, Wang W, Gao F, Yi J
J Biol Chem. 2010
PubMed ID: 20181954
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Dev Cell. 2010
PubMed ID: 20412781
Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.
Zhang XW, Yan XJ, Zhou ZR, Yang FF, Wu ZY, Sun HB, Liang WX, Song AX, Lallemand-Breitenbach V, Jeanne M, Zhang QY, Yang HY, Huang QH, Zhou GB, Tong JH, Zhang Y, Wu JH, Hu HY, de Thé H, Chen SJ, Chen Z
Science. 2010
PubMed ID: 20378816
An Oct4-centered protein interaction network in embryonic stem cells.
van den Berg DL, Snoek T, Mullin NP, Yates A, Bezstarosti K, Demmers J, Chambers I, Poot RA
Cell Stem Cell. 2010
PubMed ID: 20362541
Dysregulation of promyelocytic leukemia (PML) protein expression in preeclamptic placentae.
Leavenworth JD, Groesch KA, Xin Hu, Malm S, Torry RJ, Abrams R, Torry DS
Reprod Sci. 2010
PubMed ID: 20228380
Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y
Int J Mol Med. 2010
PubMed ID: 20198315
Gamma interferon-dependent transcriptional memory via relocalization of a gene locus to PML nuclear bodies.
Gialitakis M, Arampatzi P, Makatounakis T, Papamatheakis J
Mol Cell Biol. 2010
PubMed ID: 20123968
Promyelocytic leukemia protein controls cell migration in response to hydrogen peroxide and insulin-like growth factor-1.
Reineke EL, Liu Y, Kao HY
J Biol Chem. 2010
PubMed ID: 20100838
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
PML/RARalpha fusion protein transactivates the tissue factor promoter through a GAGC-containing element without direct DNA association.
Yan J, Wang K, Dong L, Liu H, Chen W, Xi W, Ding Q, Kieffer N, Caen JP, Chen S, Chen Z, Xi X
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133705
PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia.
Wang K, Wang P, Shi J, Zhu X, He M, Jia X, Yang X, Qiu F, Jin W, Qian M, Fang H, Mi J, Yang X, Xiao H, Minden M, Du Y, Chen Z, Zhang J
Cancer Cell. 2010
PubMed ID: 20159610
PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.
Martens JH, Brinkman AB, Simmer F, Francoijs KJ, Nebbioso A, Ferrara F, Altucci L, Stunnenberg HG
Cancer Cell. 2010
PubMed ID: 20159609
Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element.
Sinha S, Malonia SK, Mittal SP, Singh K, Kadreppa S, Kamat R, Mukhopadhyaya R, Pal JK, Chattopadhyay S
EMBO J. 2010
PubMed ID: 20075864
Three-dimensional organization of promyelocytic leukemia nuclear bodies.
Lang M, Jegou T, Chung I, Richter K, Münch S, Udvarhelyi A, Cremer C, Hemmerich P, Engelhardt J, Hell SW, Rippe K
J Cell Sci. 2010
PubMed ID: 20130140
PML-RARalpha ligand-binding domain deletion mutations associated with reduced disease control and outcome after first relapse of APL.
Schachter-Tokarz E, Kelaidi C, Cassinat B, Chomienne C, Gardin C, Raffoux E, Dombret H, Fenaux P, Gallagher R
Leukemia. 2010
PubMed ID: 19865110
Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation.
Warren DT, Tajsic T, Mellad JA, Searles R, Zhang Q, Shanahan CM
J Biol Chem. 2010
PubMed ID: 19861416
Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein.
Jul-Larsen A, Grudic A, Bjerkvig R, Bøe SO
BMC Mol Biol. 2010
PubMed ID: 21092142
Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.
Hung MS, Lin YC, Mao JH, Kim IJ, Xu Z, Yang CT, Jablons DM, You L
PLoS One. 2010
PubMed ID: 20625391
Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y
Am J Hypertens. 2010
PubMed ID: 19851296
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
Differential suppressive effect of promyelocytic leukemia protein on the replication of different subtypes/strains of influenza A virus.
Li W, Wang G, Zhang H, Zhang D, Zeng J, Chen X, Xu Y, Li K
Biochem Biophys Res Commun. 2009
PubMed ID: 19703418
Promyelocytic leukemia nuclear bodies link the DNA damage repair pathway with hepatitis B virus replication: implications for hepatitis B virus exacerbation during chemotherapy and radiotherapy.
Chung YL, Tsai TY
Mol Cancer Res. 2009
PubMed ID: 19808906
PML involvement in the p73-mediated E1A-induced suppression of EGFR and induction of apoptosis in head and neck cancers.
Klanrit P, Taebunpakul P, Flinterman MB, Odell EW, Riaz MA, Melino G, Salomoni P, Mymryk JS, Gäken J, Farzaneh F, Tavassoli M
Oncogene. 2009
PubMed ID: 19597475
Kaposi's sarcoma-associated herpesvirus protein LANA2 disrupts PML oncogenic domains and inhibits PML-mediated transcriptional repression of the survivin gene.
Marcos-Villar L, Lopitz-Otsoa F, Gallego P, Muñoz-Fontela C, González-Santamaría J, Campagna M, Shou-Jiang G, Rodriguez MS, Rivas C
J Virol. 2009
PubMed ID: 19553342
PML-IV functions as a negative regulator of telomerase by interacting with TERT.
Oh W, Ghim J, Lee EW, Yang MR, Kim ET, Ahn JH, Song J
J Cell Sci. 2009
PubMed ID: 19567472
E6AP promotes the degradation of the PML tumor suppressor.
Louria-Hayon I, Alsheich-Bartok O, Levav-Cohen Y, Silberman I, Berger M, Grossman T, Matentzoglu K, Jiang YH, Muller S, Scheffner M, Haupt S, Haupt Y
Cell Death Differ. 2009
PubMed ID: 19325566
PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors.
Wojiski S, Guibal FC, Kindler T, Lee BH, Jesneck JL, Fabian A, Tenen DG, Gilliland DG
Leukemia. 2009
PubMed ID: 19322209
Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy.
Laane E, Tamm KP, Buentke E, Ito K, Kharaziha P, Khahariza P, Oscarsson J, Corcoran M, Björklund AC, Hultenby K, Lundin J, Heyman M, Söderhäll S, Mazur J, Porwit A, Pandolfi PP, Zhivotovsky B, Panaretakis T, Grandér D
Cell Death Differ. 2009
PubMed ID: 19390558
Role of SUMO in RNF4-mediated promyelocytic leukemia protein (PML) degradation: sumoylation of PML and phospho-switch control of its SUMO binding domain dissected in living cells.
Percherancier Y, Germain-Desprez D, Galisson F, Mascle XH, Dianoux L, Estephan P, Chelbi-Alix MK, Aubry M
J Biol Chem. 2009
PubMed ID: 19380586
Promyelocytic leukemia protein is required for gain of function by mutant p53.
Haupt S, di Agostino S, Mizrahi I, Alsheich-Bartok O, Voorhoeve M, Damalas A, Blandino G, Haupt Y
Cancer Res. 2009
PubMed ID: 19487292
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ
Mol Cell Proteomics. 2009
PubMed ID: 19131326
A functional screen to identify novel effectors of hematopoietic stem cell activity.
Deneault E, Cellot S, Faubert A, Laverdure JP, Fréchette M, Chagraoui J, Mayotte N, Sauvageau M, Ting SB, Sauvageau G
Cell. 2009
PubMed ID: 19379700
Cell-cycle regulation and dynamics of cytoplasmic compartments containing the promyelocytic leukemia protein and nucleoporins.
Jul-Larsen A, Grudic A, Bjerkvig R, Bøe SO
J Cell Sci. 2009
PubMed ID: 19339552
Promyelocytic leukemia protein induces apoptosis due to caspase-8 activation via the repression of NFkappaB activation in glioblastoma.
Kuwayama K, Matsuzaki K, Mizobuchi Y, Mure H, Kitazato KT, Kageji T, Nakao M, Nagahiro S
Neuro Oncol. 2009
PubMed ID: 18812519
PML3 Orchestrates the Nuclear Dynamics and Function of TIP60.
Wu Q, Hu H, Lan J, Emenari C, Wang Z, Chang KS, Huang H, Yao X
J Biol Chem. 2009
PubMed ID: 19150978
PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool.
Li W, Ferguson BJ, Khaled WT, Tevendale M, Stingl J, Poli V, Rich T, Salomoni P, Watson CJ
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19261859
PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage.
Gresko E, Ritterhoff S, Sevilla-Perez J, Roscic A, Fröbius K, Kotevic I, Vichalkovski A, Hess D, Hemmings BA, Schmitz ML
Oncogene. 2009
PubMed ID: 19015637
The tumor suppressor Pml regulates cell fate in the developing neocortex.
Regad T, Bellodi C, Nicotera P, Salomoni P
Nat Neurosci. 2009
PubMed ID: 19136970
The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope.
Perfettini JL, Nardacci R, Séror C, Bourouba M, Subra F, Gros L, Manic G, Amendola A, Masdehors P, Rosselli F, Ojcius DM, Auclair C, de Thé H, Gougeon ML, Piacentini M, Kroemer G
Cell Death Differ. 2009
PubMed ID: 19023333
Acute promyelocytic leukemia with insertion of PML exon 7a and partial deletion of exon 3 of RARA: a novel variant transcript related to aggressive course and not detected with real-time polymerase chain reaction analysis.
Park TS, Kim JS, Song J, Lee KA, Yoon S, Suh B, Lee JH, Lee HJ, Kim JK, Choi JR
Cancer Genet Cytogenet. 2009
PubMed ID: 19100514
Germline variants of the promyelocytic leukemia tumor suppressor gene in patients with familial cancer.
Plevova P, Walczyskova S, Jeziskova I, Jurckova N, Krepelova A, Puchmajerova A, Pavlikova K, Foretova L, Zapletalova J, Silhanova E
Neoplasma. 2009
PubMed ID: 19728758
A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.
van Wijk SJ, de Vries SJ, Kemmeren P, Huang A, Boelens R, Bonvin AM, Timmers HT
Mol Syst Biol. 2009
PubMed ID: 19690564
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Identification of PML/RARalpha fusion gene transcripts that showed no t(15;17) with conventional karyotyping and fluorescent in situ hybridization.
Choughule A, Polampalli S, Amre P, Shinde S, Banavali S, Prabhash K, Nair R, Subramanian PG, Gujral S, Parikh PM
Genet Mol Res. 2009
PubMed ID: 19224461
HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3.
Gupta P, Ho PC, Ha SG, Lin YW, Wei LN
PLoS One. 2009
PubMed ID: 19204783
The two functions of herpes simplex virus 1 ICP0, inhibition of silencing by the CoREST/REST/HDAC complex and degradation of PML, are executed in tandem.
Gu H, Roizman B
J Virol. 2009
PubMed ID: 18945770
Promyelocytic leukemia (PML) gene expression is a prognostic factor in ampullary cancer patients.
Vincenzi B, Santini D, Perrone G, Russo A, Adamo V, Rizzo S, Castri F, Antinori A, Alloni R, Crucitti PF, Morini S, Rabitti C, Vecchio FM, Magistrelli P, Coppola R, Tonini G
Ann Oncol. 2009
PubMed ID: 18689862
PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.
Lapi E, Di Agostino S, Donzelli S, Gal H, Domany E, Rechavi G, Pandolfi PP, Givol D, Strano S, Lu X, Blandino G
Mol Cell. 2008
PubMed ID: 19111660
Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Enjuanes A, Benavente Y, Bosch F, Martín-Guerrero I, Colomer D, Pérez-Alvarez S, Reina O, Ardanaz MT, Jares P, García-Orad A, Pujana MA, Montserrat E, de Sanjosé S, Campo E
Cancer Res. 2008
PubMed ID: 19074885
Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.
Wang B, Malik R, Nigg EA, Körner R
Anal Chem. 2008
PubMed ID: 19007248
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation.
Nasr R, Guillemin MC, Ferhi O, Soilihi H, Peres L, Berthier C, Rousselot P, Robledo-Sarmiento M, Lallemand-Breitenbach V, Gourmel B, Vitoux D, Pandolfi PP, Rochette-Egly C, Zhu J, de Thé H
Nat Med. 2008
PubMed ID: 19029980
PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.
Shima Y, Shima T, Chiba T, Irimura T, Pandolfi PP, Kitabayashi I
Mol Cell Biol. 2008
PubMed ID: 18809579
Activating mutations in human acute megakaryoblastic leukemia.
Malinge S, Ragu C, Della-Valle V, Pisani D, Constantinescu SN, Perez C, Villeval JL, Reinhardt D, Landman-Parker J, Michaux L, Dastugue N, Baruchel A, Vainchenker W, Bourquin JP, Penard-Lacronique V, Bernard OA
Blood. 2008
PubMed ID: 18755984
PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase.
Li L, Wang J, Ye RD, Shi G, Jin H, Tang X, Yi J
J Cell Physiol. 2008
PubMed ID: 18636556
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network.
Song MS, Salmena L, Carracedo A, Egia A, Lo-Coco F, Teruya-Feldstein J, Pandolfi PP
Nature. 2008
PubMed ID: 18716620
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.
Morey L, Brenner C, Fazi F, Villa R, Gutierrez A, Buschbeck M, Nervi C, Minucci S, Fuks F, Di Croce L
Mol Cell Biol. 2008
PubMed ID: 18644863
Arsenic trioxide stimulates SUMO-2/3 modification leading to RNF4-dependent proteolytic targeting of PML.
Weisshaar SR, Keusekotten K, Krause A, Horst C, Springer HM, Göttsche K, Dohmen RJ, Praefcke GJ
FEBS Lett. 2008
PubMed ID: 18708055
Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis.
Hayakawa F, Abe A, Kitabayashi I, Pandolfi PP, Naoe T
J Biol Chem. 2008
PubMed ID: 18621739
Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.
Zhou H, Ye M, Dong J, Han G, Jiang X, Wu R, Zou H
J Proteome Res. 2008
PubMed ID: 18630941
Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation.
Gao C, Ho CC, Reineke E, Lam M, Cheng X, Stanya KJ, Liu Y, Chakraborty S, Shih HM, Kao HY
Mol Cell Biol. 2008
PubMed ID: 18625722
CK2 mediates phosphorylation and ubiquitin-mediated degradation of the PML tumor suppressor.
Scaglioni PP, Yung TM, Choi SC, Baldini C, Konstantinidou G, Pandolfi PP
Mol Cell Biochem. 2008
PubMed ID: 18566754
Dynamics of component exchange at PML nuclear bodies.
Weidtkamp-Peters S, Lenser T, Negorev D, Gerstner N, Hofmann TG, Schwanitz G, Hoischen C, Maul G, Dittrich P, Hemmerich P
J Cell Sci. 2008
PubMed ID: 18664490
Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression.
Gupta P, Ho PC, Huq MM, Ha SG, Park SW, Khan AA, Tsai NP, Wei LN
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18682553
Ubc9 sumoylation regulates SUMO target discrimination.
Knipscheer P, Flotho A, Klug H, Olsen JV, van Dijk WJ, Fish A, Johnson ES, Mann M, Sixma TK, Pichler A
Mol Cell. 2008
PubMed ID: 18691969
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Cellular proteins PML and Daxx mediate an innate antiviral defense antagonized by the adenovirus E4 ORF3 protein.
Ullman AJ, Hearing P
J Virol. 2008
PubMed ID: 18480450
Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling.
Faresse N, Colland F, Ferrand N, Prunier C, Bourgeade MF, Atfi A
EMBO J. 2008
PubMed ID: 18511908
[Increase of BIRC5 gene expression in non-small cell lung cancer and esophageal squamous cell carcinoma does not correlate with expression of genes SMAC/DIABLO and PML encoding its inhibitors]
Vaĭshlia NA, Zinov'eva MV, Sass AV, Kopantsev EP, Vinogradova TV, Sverdlov ED
Mol Biol (Mosk). 2008
PubMed ID: 18856066
Signal-dependent regulation of transcription by histone deacetylase 7 involves recruitment to promyelocytic leukemia protein nuclear bodies.
Gao C, Cheng X, Lam M, Liu Y, Liu Q, Chang KS, Kao HY
Mol Biol Cell. 2008
PubMed ID: 18463162
PML targeting eradicates quiescent leukaemia-initiating cells.
Ito K, Bernardi R, Morotti A, Matsuoka S, Saglio G, Ikeda Y, Rosenblatt J, Avigan DE, Teruya-Feldstein J, Pandolfi PP
Nature. 2008
PubMed ID: 18469801
Selective activation of NFAT by promyelocytic leukemia protein.
Lo YH, Wu CC, Shih HM, Lai MZ
Oncogene. 2008
PubMed ID: 18246125
PML enhances the regulation of p53 by CK1 in response to DNA damage.
Alsheich-Bartok O, Haupt S, Alkalay-Snir I, Saito S, Appella E, Haupt Y
Oncogene. 2008
PubMed ID: 18246126
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells.
Liang J, Wan M, Zhang Y, Gu P, Xin H, Jung SY, Qin J, Wong J, Cooney AJ, Liu D, Songyang Z
Nat Cell Biol. 2008
PubMed ID: 18454139
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation.
Tatham MH, Geoffroy MC, Shen L, Plechanovova A, Hattersley N, Jaffray EG, Palvimo JJ, Hay RT
Nat Cell Biol. 2008
PubMed ID: 18408734
Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha.
Krämer OH, Müller S, Buchwald M, Reichardt S, Heinzel T
FASEB J. 2008
PubMed ID: 18073335
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
The genetic characterization of acute promyelocytic leukemia with cryptic t(15;17) including a new recurrent additional cytogenetic abnormality i(17)(q10).
Kim M, Lim J, Kim Y, Han K, Lee DH, Chung NG, Cho B, Kim HK, Eom KS, Min CK, Min WS
Leukemia. 2008
PubMed ID: 17943164
Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein.
Shimada N, Shinagawa T, Ishii S
Genes Cells. 2008
PubMed ID: 18298799
Topoisomerase IIbeta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistance.
McNamara S, Wang H, Hanna N, Miller WH
Mol Cell Biol. 2008
PubMed ID: 18212063
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.
Hoemme C, Peerzada A, Behre G, Wang Y, McClelland M, Nieselt K, Zschunke M, Disselhoff C, Agrawal S, Isken F, Tidow N, Berdel WE, Serve H, Müller-Tidow C
Blood. 2008
PubMed ID: 18024792
Hes6 controls cell proliferation via interaction with cAMP-response element-binding protein-binding protein in the promyelocytic leukemia nuclear body.
Eun B, Lee Y, Hong S, Kim J, Lee HW, Kim K, Sun W, Kim H
J Biol Chem. 2008
PubMed ID: 18160400
Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells.
Reineke EL, Lam M, Liu Q, Liu Y, Stanya KJ, Chang KS, Means AR, Kao HY
Mol Cell Biol. 2008
PubMed ID: 18039859
Phosphorylation of PML is essential for activation of C/EBP epsilon and PU.1 to accelerate granulocytic differentiation.
Tagata Y, Yoshida H, Nguyen LA, Kato H, Ichikawa H, Tashiro F, Kitabayashi I
Leukemia. 2008
PubMed ID: 17989716
Coiled-coil domain of PML is essential for the aberrant dynamics of PML-RARalpha, resulting in sequestration and decreased mobility of SMRT.
Huang Y, Qiu J, Chen G, Dong S
Biochem Biophys Res Commun. 2008
PubMed ID: 17991421
Epstein-Barr nuclear antigen 1 contributes to nasopharyngeal carcinoma through disruption of PML nuclear bodies.
Sivachandran N, Sarkari F, Frappier L
PLoS Pathog. 2008
PubMed ID: 18833293
The presence of a single PML-RARA isoform lacking exon 5 in FISH-negative APL samples.
Ashur-Fabian O, Trakhtenbrot L, Dominissini D, Koren-Michowitz M, Nagler A, Rechavi G, Amariglio N
Leukemia. 2008
PubMed ID: 17960172
Nuclear domain 10 components promyelocytic leukemia protein and hDaxx independently contribute to an intrinsic antiviral defense against human cytomegalovirus infection.
Tavalai N, Papior P, Rechter S, Stamminger T
J Virol. 2008
PubMed ID: 17942542
Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA.
Stagno D'Alcontres M, Mendez-Bermudez A, Foxon JL, Royle NJ, Salomoni P
J Cell Biol. 2007
PubMed ID: 18056407
Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML.
Vaitiekunaite R, Butkiewicz D, Krześniak M, Przybyłek M, Gryc A, Snietura M, Benedyk M, Harris CC, Rusin M
Mech Ageing Dev. 2007
PubMed ID: 17996922
Concordant expression of proto-oncogene promyelocytic leukemia and major histocompatibility antigen HLA class I in human hepatocellular carcinoma.
Xia M, Zhang JQ, Shen YQ, Xu LH, Chen AQ, Miao FQ, Xie W
Tissue Antigens. 2007
PubMed ID: 17767548
Induction of promyelocytic leukemia (PML) oncogenic domains (PODs) by papillomavirus.
Nakahara T, Lambert PF
Virology. 2007
PubMed ID: 17543368
A nucleolar targeting signal in PML-I addresses PML to nucleolar caps in stressed or senescent cells.
Condemine W, Takahashi Y, Le Bras M, de Thé H
J Cell Sci. 2007
PubMed ID: 17878236
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation.
Yoshida H, Ichikawa H, Tagata Y, Katsumoto T, Ohnishi K, Akao Y, Naoe T, Pandolfi PP, Kitabayashi I
Mol Cell Biol. 2007
PubMed ID: 17562868
RXR is an essential component of the oncogenic PML/RARA complex in vivo.
Zhu J, Nasr R, Pérès L, Riaucoux-Lormière F, Honoré N, Berthier C, Kamashev D, Zhou J, Vitoux D, Lavau C, de Thé H
Cancer Cell. 2007
PubMed ID: 17613434
PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells.
Janderová-Rossmeislová L, Nováková Z, Vlasáková J, Philimonenko V, Hozák P, Hodný Z
J Struct Biol. 2007
PubMed ID: 17428679
Aberrant association of promyelocytic leukemia protein-retinoic acid receptor-alpha with coactivators contributes to its ability to regulate gene expression.
Reineke EL, Liu H, Lam M, Liu Y, Kao HY
J Biol Chem. 2007
PubMed ID: 17475621
PML4 induces differentiation by Myc destabilization.
Buschbeck M, Uribesalgo I, Ledl A, Gutierrez A, Minucci S, Muller S, Di Croce L
Oncogene. 2007
PubMed ID: 17146439
The chromatin remodeling factor Mi-2alpha acts as a novel co-activator for human c-Myb.
Saether T, Berge T, Ledsaak M, Matre V, Alm-Kristiansen AH, Dahle O, Aubry F, Gabrielsen OS
J Biol Chem. 2007
PubMed ID: 17344210
Nuclear phospholipase C gamma: punctate distribution and association with the promyelocytic leukemia protein.
Ferguson BJ, Dovey CL, Lilley K, Wyllie AH, Rich T
J Proteome Res. 2007
PubMed ID: 17419608
Dynamic regulation of p53 subnuclear localization and senescence by MORC3.
Takahashi K, Yoshida N, Murakami N, Kawata K, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Zinn AR, Shime H, Inoue N
Mol Biol Cell. 2007
PubMed ID: 17332504
Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts.
Meinecke I, Cinski A, Baier A, Peters MA, Dankbar B, Wille A, Drynda A, Mendoza H, Gay RE, Hay RT, Ink B, Gay S, Pap T
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360386
Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies.
Janssen K, Hofmann TG, Jans DA, Hay RT, Schulze-Osthoff K, Fischer U
Oncogene. 2007
PubMed ID: 16924230
Histone deacetylase inhibitors suppress IFNalpha-induced up-regulation of promyelocytic leukemia protein.
Vlasáková J, Nováková Z, Rossmeislová L, Kahle M, Hozák P, Hodny Z
Blood. 2007
PubMed ID: 17062732
PRIMA-1(MET) induces nucleolar accumulation of mutant p53 and PML nuclear body-associated proteins.
Rökaeus N, Klein G, Wiman KG, Szekely L, Mattsson K
Oncogene. 2007
PubMed ID: 16909106
Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.
Molina H, Horn DM, Tang N, Mathivanan S, Pandey A
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17287340
[Expression of PML in carcinogenesis of laryngocarcinoma and nasopharyngeal carcinoma].
Chen W, Yao W, Chen S, Xiao B, Tao Z
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007
PubMed ID: 17441430
Identification of PML-RARA rearrangement by RT-PCR and sequencing in an acute promyelocytic leukemia without t(15;17) on G-banding and FISH.
Han JY, Kim KE, Kim KH, Park JI, Kim JS
Leuk Res. 2007
PubMed ID: 16797070
Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas.
Chang HJ, Yoo BC, Kim SW, Lee BL, Kim WH
Pathol Oncol Res. 2007
PubMed ID: 18158568
PML protein expression in hereditary and sporadic breast cancer.
Plevová P, Bouchal J, Fiurásková M, Foretová L, Navrátilová M, Zapletalová J, Curík R, Kubala O, Prokop J, Kolár Z
Neoplasma. 2007
PubMed ID: 17822314
Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus.
Kumar PP, Bischof O, Purbey PK, Notani D, Urlaub H, Dejean A, Galande S
Nat Cell Biol. 2007
PubMed ID: 17173041
The promyelocytic leukemia protein functions as a negative regulator of IFN-gamma signaling.
Choi YH, Bernardi R, Pandolfi PP, Benveniste EN
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17121994
ZNF198, a zinc finger protein rearranged in myeloproliferative disease, localizes to the PML nuclear bodies and interacts with SUMO-1 and PML.
Kunapuli P, Kasyapa CS, Chin SF, Caldas C, Cowell JK
Exp Cell Res. 2006
PubMed ID: 17027752
The mechanisms of PML-nuclear body formation.
Shen TH, Lin HK, Scaglioni PP, Yung TM, Pandolfi PP
Mol Cell. 2006
PubMed ID: 17081985
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
A cytoplasmic PML mutant inhibits p53 function.
Bellodi C, Kindle K, Bernassola F, Cossarizza A, Dinsdale D, Melino G, Heery D, Salomoni P
Cell Cycle. 2006
PubMed ID: 17172828
Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR.
Dellaire G, Ching RW, Ahmed K, Jalali F, Tse KC, Bristow RG, Bazett-Jones DP
J Cell Biol. 2006
PubMed ID: 17030982
Retinoic acid induces leukemia cell G1 arrest and transition into differentiation by inhibiting cyclin-dependent kinase-activating kinase binding and phosphorylation of PML/RARalpha.
Wang JG, Barsky LW, Davicioni E, Weinberg KI, Triche TJ, Zhang XK, Wu L
FASEB J. 2006
PubMed ID: 16935935
ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis.
Joe Y, Jeong JH, Yang S, Kang H, Motoyama N, Pandolfi PP, Chung JH, Kim MK
J Biol Chem. 2006
PubMed ID: 16891316
Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation.
Yang S, Jeong JH, Brown AL, Lee CH, Pandolfi PP, Chung JH, Kim MK
J Biol Chem. 2006
PubMed ID: 16835227
Cross talk between PML and p53 during poliovirus infection: implications for antiviral defense.
Pampin M, Simonin Y, Blondel B, Percherancier Y, Chelbi-Alix MK
J Virol. 2006
PubMed ID: 16912307
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR.
Bernardi R, Guernah I, Jin D, Grisendi S, Alimonti A, Teruya-Feldstein J, Cordon-Cardo C, Simon MC, Rafii S, Pandolfi PP
Nature. 2006
PubMed ID: 16915281
Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling.
Seo SR, Ferrand N, Faresse N, Prunier C, Abécassis L, Pessah M, Bourgeade MF, Atfi A
Mol Cell. 2006
PubMed ID: 16916642
Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infections.
Tavalai N, Papior P, Rechter S, Leis M, Stamminger T
J Virol. 2006
PubMed ID: 16873257
PML contributes to a cellular mechanism of repression of herpes simplex virus type 1 infection that is inactivated by ICP0.
Everett RD, Rechter S, Papior P, Tavalai N, Stamminger T, Orr A
J Virol. 2006
PubMed ID: 16873256
A CK2-dependent mechanism for degradation of the PML tumor suppressor.
Scaglioni PP, Yung TM, Cai LF, Erdjument-Bromage H, Kaufman AJ, Singh B, Teruya-Feldstein J, Tempst P, Pandolfi PP
Cell. 2006
PubMed ID: 16873060
PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins.
Janer A, Martin E, Muriel MP, Latouche M, Fujigasaki H, Ruberg M, Brice A, Trottier Y, Sittler A
J Cell Biol. 2006
PubMed ID: 16818720
Characterization of endogenous human promyelocytic leukemia isoforms.
Condemine W, Takahashi Y, Zhu J, Puvion-Dutilleul F, Guegan S, Janin A, de Thé H
Cancer Res. 2006
PubMed ID: 16778193
Pro-proliferative function of the long isoform of PML-RARalpha involved in acute promyelocytic leukemia.
Tussié-Luna MI, Rozo L, Roy AL
Oncogene. 2006
PubMed ID: 16434964
Identification of a tumour suppressor network opposing nuclear Akt function.
Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP
Nature. 2006
PubMed ID: 16680151
Cytoplasmic function of mutant promyelocytic leukemia (PML) and PML-retinoic acid receptor-alpha.
Bellodi C, Kindle K, Bernassola F, Dinsdale D, Cossarizza A, Melino G, Heery D, Salomoni P
J Biol Chem. 2006
PubMed ID: 16540467
The promyelocytic leukemia protein stimulates SUMO conjugation in yeast.
Quimby BB, Yong-Gonzalez V, Anan T, Strunnikov AV, Dasso M
Oncogene. 2006
PubMed ID: 16501610
Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.
Fenske TS, McMahon C, Edwin D, Jarvis JC, Cheverud JM, Minn M, Mathews V, Bogue MA, Province MA, McLeod HL, Graubert TA
Cancer Res. 2006
PubMed ID: 16707424
Functional interactions between the Epstein-Barr virus BZLF1 protein and the promyelocytic leukemia protein.
Bowling BL, Adamson AL
Virus Res. 2006
PubMed ID: 16307818
PML-RARalpha fusion gene transcripts and biological features in acute promyelocytic leukemia patients.
Melo RA, de Vasconcellos JF, Melo FC, Machado CG, Lacerda TM, Souto FR
Clin Lab Haematol. 2006
PubMed ID: 16630218
PML-associated repressor of transcription (PAROT), a novel KRAB-zinc finger repressor, is regulated through association with PML nuclear bodies.
Fleischer S, Wiemann S, Will H, Hofmann TG
Exp Cell Res. 2006
PubMed ID: 16412420
Analysis of the DNA sequence and duplication history of human chromosome 15.
Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C
Nature. 2006
PubMed ID: 16572171
Interaction of the adenovirus type 5 E4 Orf3 protein with promyelocytic leukemia protein isoform II is required for ND10 disruption.
Hoppe A, Beech SJ, Dimmock J, Leppard KN
J Virol. 2006
PubMed ID: 16501113
A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein.
Qin Q, Inatome R, Hotta A, Kojima M, Yamamura H, Hirai H, Yoshizawa T, Tanaka H, Fukami K, Yanagi S
J Cell Biol. 2006
PubMed ID: 16461359
Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.
Shiio Y, Rose DW, Aur R, Donohoe S, Aebersold R, Eisenman RN
Mol Cell Biol. 2006
PubMed ID: 16449650
Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein.
Carbone R, Botrugno OA, Ronzoni S, Insinga A, Di Croce L, Pelicci PG, Minucci S
Mol Cell Biol. 2006
PubMed ID: 16449642
The methyl-CpG binding protein MBD1 is required for PML-RARalpha function.
Villa R, Morey L, Raker VA, Buschbeck M, Gutierrez A, De Santis F, Corsaro M, Varas F, Bossi D, Minucci S, Pelicci PG, Di Croce L
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16432238
Serum-dependent expression of promyelocytic leukemia protein suppresses propagation of influenza virus.
Iki S, Yokota S, Okabayashi T, Yokosawa N, Nagata K, Fujii N
Virology. 2005
PubMed ID: 16154611
The promyelocytic leukaemia protein tumour suppressor functions as a transcriptional regulator of p63.
Bernassola F, Oberst A, Melino G, Pandolfi PP
Oncogene. 2005
PubMed ID: 16007146
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.
Walter MJ, Park JS, Ries RE, Lau SK, McLellan M, Jaeger S, Wilson RK, Mardis ER, Ley TJ
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16113082
Isoforms of the promyelocytic leukemia protein differ in their effects on ND10 organization.
Beech SJ, Lethbridge KJ, Killick N, McGlincy N, Leppard KN
Exp Cell Res. 2005
PubMed ID: 15922731
Immediate early gene X1 (IEX-1) is organized in subnuclear structures and partially co-localizes with promyelocytic leukemia protein in HeLa cells.
Kruse ML, Arlt A, Sieke A, Grohmann F, Grossmann M, Minkenberg J, Fölsch UR, Schäfer H
J Biol Chem. 2005
PubMed ID: 15855159
[Role of molecular screening for common fusion genes in the diagnosis and classification of leukemia]
Zhu YL, Zhang Y, Zhu P, Yang Y, Du JW, Liu J
Beijing Da Xue Xue Bao. 2005
PubMed ID: 15968309
Promyelocytic leukemia zinc finger protein localizes to the cochlear outer hair cells and interacts with prestin, the outer hair cell motor protein.
Nagy I, Bodmer M, Schmid S, Bodmer D
Hear Res. 2005
PubMed ID: 15925207
Requirement of the coiled-coil domain of PML-RARalpha oncoprotein for localization, sumoylation, and inhibition of monocyte differentiation.
Kim YE, Kim DY, Lee JM, Kim ST, Han TH, Ahn JH
Biochem Biophys Res Commun. 2005
PubMed ID: 15809060
Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells.
Ikeda T, Kimura F, Nakata Y, Sato K, Ogura K, Motoyoshi K, Sporn M, Kufe D
Cell Death Differ. 2005
PubMed ID: 15746941
The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage.
Salomoni P, Bernardi R, Bergmann S, Changou A, Tuttle S, Pandolfi PP
Blood. 2005
PubMed ID: 15626733
PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts.
Cairo S, De Falco F, Pizzo M, Salomoni P, Pandolfi PP, Meroni G
Oncogene. 2005
PubMed ID: 15735755
A role for PML3 in centrosome duplication and genome stability.
Xu ZX, Zou WX, Lin P, Chang KS
Mol Cell. 2005
PubMed ID: 15749021
Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein.
Takahashi H, Hatakeyama S, Saitoh H, Nakayama KI
J Biol Chem. 2005
PubMed ID: 15569683
PML mediates IFN-alpha-induced apoptosis in myeloma by regulating TRAIL induction.
Crowder C, Dahle Ø, Davis RE, Gabrielsen OS, Rudikoff S
Blood. 2005
PubMed ID: 15459016
Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells.
Lane AA, Ley TJ
Mol Cell Biol. 2005
PubMed ID: 15601827
A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers.
Rosas-Acosta G, Russell WK, Deyrieux A, Russell DH, Wilson VG
Mol Cell Proteomics. 2005
PubMed ID: 15576338
Physical and functional link of the leukemia-associated factors AML1 and PML.
Nguyen LA, Pandolfi PP, Aikawa Y, Tagata Y, Ohki M, Kitabayashi I
Blood. 2005
PubMed ID: 15331439
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
Ini1/hSNF5 is dispensable for retrovirus-induced cytoplasmic accumulation of PML and does not interfere with integration.
Boese A, Sommer P, Gaussin A, Reimann A, Nehrbass U
FEBS Lett. 2004
PubMed ID: 15589835
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Expression profiling of murine acute promyelocytic leukemia cells reveals multiple model-dependent progression signatures.
Walter MJ, Park JS, Lau SK, Li X, Lane AA, Nagarajan R, Shannon WD, Ley TJ
Mol Cell Biol. 2004
PubMed ID: 15572690
PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein.
Daniels MJ, Marson A, Venkitaraman AR
Nat Struct Mol Biol. 2004
PubMed ID: 15467728
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase.
Shin J, Park B, Cho S, Lee S, Kim Y, Lee SO, Cho K, Lee S, Jin BS, Ahn JH, Choi EJ, Ahn K
J Biol Chem. 2004
PubMed ID: 15273249
Cytoplasmic PML function in TGF-beta signalling.
Lin HK, Bergmann S, Pandolfi PP
Nature. 2004
PubMed ID: 15356634
Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX.
Ishov AM, Vladimirova OV, Maul GG
J Cell Sci. 2004
PubMed ID: 15252119
More on geographic hematology: the breakpoint cluster regions of the PML/RARalpha fusion gene in Mexican Mestizo patients with promyelocytic leukemia are different from those in Caucasians.
Ruiz-Argüelles GJ, Garcés-Eisele J, Reyes-Núñez V, Gómez-Rangel JD, Ruiz-Delgado GJ
Leuk Lymphoma. 2004
PubMed ID: 15359634
PML regulates p53 stability by sequestering Mdm2 to the nucleolus.
Bernardi R, Scaglioni PP, Bergmann S, Horn HF, Vousden KH, Pandolfi PP
Nat Cell Biol. 2004
PubMed ID: 15195100
c-Myb associates with PML in nuclear bodies in hematopoietic cells.
Dahle Ø, Bakke O, Gabrielsen OS
Exp Cell Res. 2004
PubMed ID: 15194430
E2FBP1/hDril1 modulates cell growth through downregulation of promyelocytic leukemia bodies.
Fukuyo Y, Mogi K, Tsunematsu Y, Nakajima T
Cell Death Differ. 2004
PubMed ID: 15017387
Ubiquitin-dependent degradation of p73 is inhibited by PML.
Bernassola F, Salomoni P, Oberst A, Di Como CJ, Pagano M, Melino G, Pandolfi PP
J Exp Med. 2004
PubMed ID: 15184504
Nuclear partners of Bcl-2: Bax and PML.
Hoetelmans RW
DNA Cell Biol. 2004
PubMed ID: 15231068
Ability of the human cytomegalovirus IE1 protein to modulate sumoylation of PML correlates with its functional activities in transcriptional regulation and infectivity in cultured fibroblast cells.
Lee HR, Kim DJ, Lee JM, Choi CY, Ahn BY, Hayward GS, Ahn JH
J Virol. 2004
PubMed ID: 15163746
The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle.
Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G
J Mol Biol. 2004
PubMed ID: 15136035
Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein.
Suico MA, Yoshida H, Seki Y, Uchikawa T, Lu Z, Shuto T, Matsuzaki K, Nakao M, Li JD, Kai H
J Biol Chem. 2004
PubMed ID: 14976184
PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation.
Kamashev D, Vitoux D, De Thé H
J Exp Med. 2004
PubMed ID: 15096541
Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2.
Tashiro S, Muto A, Tanimoto K, Tsuchiya H, Suzuki H, Hoshino H, Yoshida M, Walter J, Igarashi K
Mol Cell Biol. 2004
PubMed ID: 15060166
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia.
Gurrieri C, Nafa K, Merghoub T, Bernardi R, Capodieci P, Biondi A, Nimer S, Douer D, Cordon-Cardo C, Gallagher R, Pandolfi PP
Blood. 2004
PubMed ID: 14630830
Impairment of p53 acetylation, stability and function by an oncogenic transcription factor.
Insinga A, Monestiroli S, Ronzoni S, Carbone R, Pearson M, Pruneri G, Viale G, Appella E, Pelicci P, Minucci S
EMBO J. 2004
PubMed ID: 14976551
PML is a direct p53 target that modulates p53 effector functions.
de Stanchina E, Querido E, Narita M, Davuluri RV, Pandolfi PP, Ferbeyre G, Lowe SW
Mol Cell. 2004
PubMed ID: 14992722
Loss of the tumor suppressor PML in human cancers of multiple histologic origins.
Gurrieri C, Capodieci P, Bernardi R, Scaglioni PP, Nafa K, Rush LJ, Verbel DA, Cordon-Cardo C, Pandolfi PP
J Natl Cancer Inst. 2004
PubMed ID: 14970276
Promyelocytic leukemia nuclear bodies associate with transcriptionally active genomic regions.
Wang J, Shiels C, Sasieni P, Wu PJ, Islam SA, Freemont PS, Sheer D
J Cell Biol. 2004
PubMed ID: 14970191
The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome.
Fanelli M, Fantozzi A, De Luca P, Caprodossi S, Matsuzawa S, Lazar MA, Pelicci PG, Minucci S
J Biol Chem. 2004
PubMed ID: 14645235
Androgen suppresses PML protein expression in prostate cancer CWR22R cells.
Yang L, Yeh SD, Xie S, Altuwaijri S, Ni J, Hu YC, Chen YT, Bao BY, Su CH, Chang C
Biochem Biophys Res Commun. 2004
PubMed ID: 14715247
Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression.
Xu ZX, Zhao RX, Ding T, Tran TT, Zhang W, Pandolfi PP, Chang KS
J Biol Chem. 2004
PubMed ID: 14597622
Cloning and functional characterization of a rat Daxx that functions as a corepressor for the androgen receptor.
Mizuta H, Kuroda Y
Cell Biol Int. 2004
PubMed ID: 15350595
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Role of PML and the PML-nuclear body in the control of programmed cell death.
Bernardi R, Pandolfi PP
Oncogene. 2003
PubMed ID: 14663483
MDM2 and promyelocytic leukemia antagonize each other through their direct interaction with p53.
Zhu H, Wu L, Maki CG
J Biol Chem. 2003
PubMed ID: 14507915
Retinoic acid receptor alpha fusion to PML affects its transcriptional and chromatin-remodeling properties.
Segalla S, Rinaldi L, Kilstrup-Nielsen C, Badaracco G, Minucci S, Pelicci PG, Landsberger N
Mol Cell Biol. 2003
PubMed ID: 14612419
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
PML/RARalpha plays a role for basal activity and retinoid-induced repression of the tissue factor promoter in acute promyelocytic leukemia cells.
Tenno T, Oberg F, Mackman N, Nilsson K, Siegbahn A
Thromb Haemost. 2003
PubMed ID: 14597990
Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis.
Puccetti E, Beissert T, Güller S, Li JE, Hoelzer D, Ottmann OG, Ruthardt M
Oncogene. 2003
PubMed ID: 14534537
Adenovirus protein IX sequesters host-cell promyelocytic leukaemia protein and contributes to efficient viral proliferation.
Rosa-Calatrava M, Puvion-Dutilleul F, Lutz P, Dreyer D, de Thé H, Chatton B, Kedinger C
EMBO Rep. 2003
PubMed ID: 14528266
High frequency of alternative splicing of human genes participating in the HIV-1 life cycle: a model using TSG101, betaTrCP, PPIA, INI1, NAF1, and PML.
Favre M, Butticaz C, Stevenson B, Jongeneel CV, Telenti A
J Acquir Immune Defic Syndr. 2003
PubMed ID: 14526201
Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
Kurki S, Latonen L, Laiho M
J Cell Sci. 2003
PubMed ID: 12915590
RecQ helicases: suppressors of tumorigenesis and premature aging.
Bachrati CZ, Hickson ID
Biochem J. 2003
PubMed ID: 12803543
Promyelocytic leukaemia (PML) protein expression in human placenta and choriocarcinoma.
Kim CJ, Yoon BH, Jun JK, Park JO, Cho SY, Romero R, Kim YM, Yu ES
J Pathol. 2003
PubMed ID: 12950020
New highly sensitive fluorescence in situ hybridization method to detect PML/RARA fusion in acute promyelocytic leukemia.
Brockman SR, Paternoster SF, Ketterling RP, Dewald GW
Cancer Genet Cytogenet. 2003
PubMed ID: 12935927
ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.
Kawai T, Akira S, Reed JC
Mol Cell Biol. 2003
PubMed ID: 12917339
The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation.
Louria-Hayon I, Grossman T, Sionov RV, Alsheich O, Pandolfi PP, Haupt Y
J Biol Chem. 2003
PubMed ID: 12810724
PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains.
Möller A, Sirma H, Hofmann TG, Rueffer S, Klimczak E, Dröge W, Will H, Schmitz ML
Cancer Res. 2003
PubMed ID: 12907596
Physical and functional interactions between PML and MDM2.
Wei X, Yu ZK, Ramalingam A, Grossman SR, Yu JH, Bloch DB, Maki CG
J Biol Chem. 2003
PubMed ID: 12759344
Forced expression of RNF36 induces cell apoptosis.
Shyu HW, Hsu SH, Hsieh-Li HM, Li H
Exp Cell Res. 2003
PubMed ID: 12837286
Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation.
Phan VT, Shultz DB, Truong BT, Blake TJ, Brown AL, Gonda TJ, Le Beau MM, Kogan SC
Mol Cell Biol. 2003
PubMed ID: 12808098
PML colocalizes with and stabilizes the DNA damage response protein TopBP1.
Xu ZX, Timanova-Atanasova A, Zhao RX, Chang KS
Mol Cell Biol. 2003
PubMed ID: 12773567
Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects.
Chee AV, Lopez P, Pandolfi PP, Roizman B
J Virol. 2003
PubMed ID: 12768029
Promyelocytic leukemia protein (PML) functions as a glucocorticoid receptor co-activator by sequestering Daxx to the PML oncogenic domains (PODs) to enhance its transactivation potential.
Lin DY, Lai MZ, Ann DK, Shih HM
J Biol Chem. 2003
PubMed ID: 12595526
Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein.
Marcello A, Ferrari A, Pellegrini V, Pegoraro G, Lusic M, Beltram F, Giacca M
EMBO J. 2003
PubMed ID: 12727882
The PML gene is not involved in the regulation of MHC class I expression in human cell lines.
Bruno S, Ghiotto F, Fais F, Fagioli M, Luzi L, Pelicci PG, Grossi CE, Ciccone E
Blood. 2003
PubMed ID: 12506025
Opposing effects of PML and PML/RAR alpha on STAT3 activity.
Kawasaki A, Matsumura I, Kataoka Y, Takigawa E, Nakajima K, Kanakura Y
Blood. 2003
PubMed ID: 12506013
THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies.
Roussigne M, Cayrol C, Clouaire T, Amalric F, Girard JP
Oncogene. 2003
PubMed ID: 12717420
Promyelocytic leukemia protein sensitizes tumor necrosis factor alpha-induced apoptosis by inhibiting the NF-kappaB survival pathway.
Wu WS, Xu ZX, Hittelman WN, Salomoni P, Pandolfi PP, Chang KS
J Biol Chem. 2003
PubMed ID: 12540841
Expression of promyelocytic leukemia protein increases during the differentiation of human neuroblastoma cells.
Yu E, Choi EK, Kim CJ
Virchows Arch. 2003
PubMed ID: 12647219
PML-nuclear bodies are involved in cellular serum response.
Matsuzaki K, Minami T, Tojo M, Honda Y, Saitoh N, Nagahiro S, Saya H, Nakao M
Genes Cells. 2003
PubMed ID: 12622724
Recruitment of herpes simplex virus type 1 transcriptional regulatory protein ICP4 into foci juxtaposed to ND10 in live, infected cells.
Everett RD, Sourvinos G, Orr A
J Virol. 2003
PubMed ID: 12610143
Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.
Ecsedy JA, Michaelson JS, Leder P
Mol Cell Biol. 2003
PubMed ID: 12529400
Cytogenetics, FISH and RT-PCR analysis of acute promyelocytic leukemia: structure of the fusion point in a case lacking classic t(15;17) translocation.
Fujita K, Oba R, Harada H, Mori H, Niikura H, Isoyama K, Omine M
Leuk Lymphoma. 2003
PubMed ID: 12691149
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system.
Tojo M, Matsuzaki K, Minami T, Honda Y, Yasuda H, Chiba T, Saya H, Fujii-Kuriyama Y, Nakao M
J Biol Chem. 2002
PubMed ID: 12354770
Control of biochemical reactions through supramolecular RING domain self-assembly.
Kentsis A, Gordon RE, Borden KL
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12438698
Rabies virus P and small P products interact directly with PML and reorganize PML nuclear bodies.
Blondel D, Regad T, Poisson N, Pavie B, Harper F, Pandolfi PP, De Thé H, Chelbi-Alix MK
Oncogene. 2002
PubMed ID: 12439746
PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2.
Yang S, Kuo C, Bisi JE, Kim MK
Nat Cell Biol. 2002
PubMed ID: 12402044
Cryptic translocation of PML/RARA on 17q. A rare event in acute promyelocytic leukemia.
Zaccaria A, Valenti A, Toschi M, Salvucci M, Cipriani R, Ottaviani E, Martinelli G
Cancer Genet Cytogenet. 2002
PubMed ID: 12505266
PML is a target gene of beta-catenin and plakoglobin, and coactivates beta-catenin-mediated transcription.
Shtutman M, Zhurinsky J, Oren M, Levina E, Ben-Ze'ev A
Cancer Res. 2002
PubMed ID: 12384561
SUMO-1 protease-1 regulates gene transcription through PML.
Best JL, Ganiatsas S, Agarwal S, Changou A, Salomoni P, Shirihai O, Meluh PB, Pandolfi PP, Zon LI
Mol Cell. 2002
PubMed ID: 12419228
Overexpression of promyelocytic leukemia protein precludes the dispersal of ND10 structures and has no effect on accumulation of infectious herpes simplex virus 1 or its proteins.
Lopez P, Jacob RJ, Roizman B
J Virol. 2002
PubMed ID: 12186918
Gamma interferon and cadmium treatments modulate eukaryotic initiation factor 4E-dependent mRNA transport of cyclin D1 in a PML-dependent manner.
Topisirovic I, Capili AD, Borden KL
Mol Cell Biol. 2002
PubMed ID: 12167712
The promyelocytic leukemia protein represses A20-mediated transcription.
Wu WS, Xu ZX, Chang KS
J Biol Chem. 2002
PubMed ID: 12080044
Differential expression of the suppressor PML and Ki-67 identifies three subtypes of human nasopharyngeal carcinoma.
Chan JY, Meng CL, To KF, Leung SF, Chan AT, Lee KK, Johnson PJ
Eur J Cancer. 2002
PubMed ID: 12142048
Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration.
Lin DY, Shih HM
J Biol Chem. 2002
PubMed ID: 11948183
An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991).
Combes R, Balls M, Bansil L, Barratt M, Bell D, Botham P, Broadhead C, Clothier R, George E, Fentem J, Jackson M, Indans I, Loizu G, Navaratnam V, Pentreath V, Phillips B, Stemplewski H, Stewart J
Altern Lab Anim. 2002
PubMed ID: 12234245
Deconstructing PML-induced premature senescence.
Bischof O, Kirsh O, Pearson M, Itahana K, Pelicci PG, Dejean A
EMBO J. 2002
PubMed ID: 12093737
The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter.
Hoffmeister A, Ropolo A, Vasseur S, Mallo GV, Bodeker H, Ritz-Laser B, Dressler GR, Vaccaro MI, Dagorn JC, Moreno S, Iovanna JL
J Biol Chem. 2002
PubMed ID: 11940591
PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model.
Kelly LM, Kutok JL, Williams IR, Boulton CL, Amaral SM, Curley DP, Ley TJ, Gilliland DG
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12060771
Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions.
Wu WS, Xu ZX, Ran R, Meng F, Chang KS
Oncogene. 2002
PubMed ID: 12032831
Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy.
Gu BW, Xiong H, Zhou Y, Chen B, Wang L, Dong S, Yu ZY, Lu LF, Zhong M, Yin HF, Zhu GF, Huang W, Ren SX, Gallagher RE, Waxman S, Chen GQ, Wang ZG, Chen Z, Fu G, Chen SJ
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12032336
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
Langley E, Pearson M, Faretta M, Bauer UM, Frye RA, Minucci S, Pelicci PG, Kouzarides T
EMBO J. 2002
PubMed ID: 12006491
Effects of promyelocytic leukemia protein on virus-host balance.
Bonilla WV, Pinschewer DD, Klenerman P, Rousson V, Gaboli M, Pandolfi PP, Zinkernagel RM, Salvato MS, Hengartner H
J Virol. 2002
PubMed ID: 11907221
UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia.
Kitareewan S, Pitha-Rowe I, Sekula D, Lowrey CH, Nemeth MJ, Golub TR, Freemantle SJ, Dmitrovsky E
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11891284
The role of PML in tumor suppression.
Salomoni P, Pandolfi PP
Cell. 2002
PubMed ID: 11832207
Arsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with Its transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemia.
Hong SH, Yang Z, Privalsky ML
Mol Cell Biol. 2001
PubMed ID: 11585900
PML interaction with p53 and its role in apoptosis and replicative senescence.
Pearson M, Pelicci PG
Oncogene. 2001
PubMed ID: 11704853
PML protein isoforms and the RBCC/TRIM motif.
Jensen K, Shiels C, Freemont PS
Oncogene. 2001
PubMed ID: 11704850
Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Piao Y, Ko NT, Lim MK, Ko MS
Genome Res. 2001
PubMed ID: 11544199
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.
Cohen N, Sharma M, Kentsis A, Perez JM, Strudwick S, Borden KL
EMBO J. 2001
PubMed ID: 11500381
PML mediates the interferon-induced antiviral state against a complex retrovirus via its association with the viral transactivator.
Regad T, Saib A, Lallemand-Breitenbach V, Pandolfi PP, de Thé H, Chelbi-Alix MK
EMBO J. 2001
PubMed ID: 11432836
Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication.
Turelli P, Doucas V, Craig E, Mangeat B, Klages N, Evans R, Kalpana G, Trono D
Mol Cell. 2001
PubMed ID: 11430827
Role of PML and PML-RARalpha in Mad-mediated transcriptional repression.
Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S
Mol Cell. 2001
PubMed ID: 11430826
The tripartite motif family identifies cell compartments.
Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A
EMBO J. 2001
PubMed ID: 11331580
The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases.
Wu WS, Vallian S, Seto E, Yang WM, Edmondson D, Roth S, Chang KS
Mol Cell Biol. 2001
PubMed ID: 11259576
Role of promyelocytic leukemia (PML) protein in tumor suppression.
Rego EM, Wang ZG, Peruzzi D, He LZ, Cordon-Cardo C, Pandolfi PP
J Exp Med. 2001
PubMed ID: 11181703
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Proteins associated with the promyelocytic leukemia gene product (PML)-containing nuclear body move to the nucleolus upon inhibition of proteasome-dependent protein degradation.
Mattsson K, Pokrovskaja K, Kiss C, Klein G, Szekely L
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11158586
Regulation of Pax3 transcriptional activity by SUMO-1-modified PML.
Lehembre F, Müller S, Pandolfi PP, Dejean A
Oncogene. 2001
PubMed ID: 11244500
RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions.
Shimono Y, Murakami H, Hasegawa Y, Takahashi M
J Biol Chem. 2000
PubMed ID: 10976108
Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF.
Dhordain P, Albagli O, Honore N, Guidez F, Lantoine D, Schmid M, The HD, Zelent A, Koken MH
Oncogene. 2000
PubMed ID: 11175338
Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice.
Zimonjic DB, Pollock JL, Westervelt P, Popescu NC, Ley TJ
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11087871
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
Fogal V, Gostissa M, Sandy P, Zacchi P, Sternsdorf T, Jensen K, Pandolfi PP, Will H, Schneider C, Del Sal G
EMBO J. 2000
PubMed ID: 11080164
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
The function of PML in p53-dependent apoptosis.
Guo A, Salomoni P, Luo J, Shih A, Zhong S, Gu W, Pandolfi PP
Nat Cell Biol. 2000
PubMed ID: 11025664
Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein.
Tsuzuki S, Towatari M, Saito H, Enver T
Mol Cell Biol. 2000
PubMed ID: 10938104
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras.
Pearson M, Carbone R, Sebastiani C, Cioce M, Fagioli M, Saito S, Higashimoto Y, Appella E, Minucci S, Pandolfi PP, Pelicci PG
Nature. 2000
PubMed ID: 10910364
A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse.
Akhmedov NB, Piriev NI, Chang B, Rapoport AL, Hawes NL, Nishina PM, Nusinowitz S, Heckenlively JR, Roderick TH, Kozak CA, Danciger M, Davisson MT, Farber DB
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10805811
Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.
Minucci S, Maccarana M, Cioce M, De Luca P, Gelmetti V, Segalla S, Di Croce L, Giavara S, Matteucci C, Gobbi A, Bianchini A, Colombo E, Schiavoni I, Badaracco G, Hu X, Lazar MA, Landsberger N, Nervi C, Pelicci PG
Mol Cell. 2000
PubMed ID: 10882117
The transcriptional role of PML and the nuclear body.
Zhong S, Salomoni P, Pandolfi PP
Nat Cell Biol. 2000
PubMed ID: 10806494
Role of SUMO-1-modified PML in nuclear body formation.
Zhong S, Müller S, Ronchetti S, Freemont PS, Dejean A, Pandolfi PP
Blood. 2000
PubMed ID: 10779416
A method to identify cDNAs based on localization of green fluorescent protein fusion products.
Misawa K, Nosaka T, Morita S, Kaneko A, Nakahata T, Asano S, Kitamura T
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10716735
Sequestration and inhibition of Daxx-mediated transcriptional repression by PML.
Li H, Leo C, Zhu J, Wu X, O'Neil J, Park EJ, Chen JD
Mol Cell Biol. 2000
PubMed ID: 10669754
Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis.
Zhong S, Salomoni P, Ronchetti S, Guo A, Ruggero D, Pandolfi PP
J Exp Med. 2000
PubMed ID: 10684855
A role for PML and the nuclear body in genomic stability.
Zhong S, Hu P, Ye TZ, Stan R, Ellis NA, Pandolfi PP
Oncogene. 1999
PubMed ID: 10637504
A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia.
Pollock JL, Westervelt P, Kurichety AK, Pelicci PG, Grisolano JL, Ley TJ
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10611345
The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control.
Topcu Z, Mack DL, Hromas RA, Borden KL
Oncogene. 1999
PubMed ID: 10597310
A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins.
Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman LP, Pandolfi PP
Nat Genet. 1999
PubMed ID: 10610177
PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1.
Ishov AM, Sotnikov AG, Negorev D, Vladimirova OV, Neff N, Kamitani T, Yeh ET, Strauss JF, Maul GG
J Cell Biol. 1999
PubMed ID: 10525530
Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling.
Doucas V, Tini M, Egan DA, Evans RM
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10077561
SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation.
Duprez E, Saurin AJ, Desterro JM, Lallemand-Breitenbach V, Howe K, Boddy MN, Solomon E, de Thé H, Hay RT, Freemont PS
J Cell Sci. 1999
PubMed ID: 9885291
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
The promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoter.
Vallian S, Chin KV, Chang KS
Mol Cell Biol. 1998
PubMed ID: 9819401
Proto-oncogene PML controls genes devoted to MHC class I antigen presentation.
Zheng P, Guo Y, Niu Q, Levy DE, Dyck JA, Lu S, Sheiman LA, Liu Y
Nature. 1998
PubMed ID: 9845074
PML is essential for multiple apoptotic pathways.
Wang ZG, Ruggero D, Ronchetti S, Zhong S, Gaboli M, Rivi R, Pandolfi PP
Nat Genet. 1998
PubMed ID: 9806545
Identification of three major sentrinization sites in PML.
Kamitani T, Kito K, Nguyen HP, Wada H, Fukuda-Kamitani T, Yeh ET
J Biol Chem. 1998
PubMed ID: 9756909
Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML.
Ahn JH, Brignole EJ, Hayward GS
Mol Cell Biol. 1998
PubMed ID: 9671498
Modulation of Fos-mediated AP-1 transcription by the promyelocytic leukemia protein.
Vallian S, Gäken JA, Gingold EB, Kouzarides T, Chang KS, Farzaneh F
Oncogene. 1998
PubMed ID: 9671405
Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis.
Chu CC, Paul WE
Mol Immunol. 1998
PubMed ID: 9798653
Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML.
Cao T, Duprez E, Borden KL, Freemont PS, Etkin LD
J Cell Sci. 1998
PubMed ID: 9570750
Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis.
Le XF, Vallian S, Mu ZM, Hung MC, Chang KS
Oncogene. 1998
PubMed ID: 9583681
Role of PML in cell growth and the retinoic acid pathway.
Wang ZG, Delva L, Gaboli M, Rivi R, Giorgio M, Cordon-Cardo C, Grosveld F, Pandolfi PP
Science. 1998
PubMed ID: 9488655
Covalent modification of PML by the sentrin family of ubiquitin-like proteins.
Kamitani T, Nguyen HP, Kito K, Fukuda-Kamitani T, Yeh ET
J Biol Chem. 1998
PubMed ID: 9452416
The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein.
Alcalay M, Tomassoni L, Colombo E, Stoldt S, Grignani F, Fagioli M, Szekely L, Helin K, Pelicci PG
Mol Cell Biol. 1998
PubMed ID: 9448006
An arenavirus RING (zinc-binding) protein binds the oncoprotein promyelocyte leukemia protein (PML) and relocates PML nuclear bodies to the cytoplasm.
Borden KL, Campbell Dwyer EJ, Salvato MS
J Virol. 1998
PubMed ID: 9420283
Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1.
Sternsdorf T, Jensen K, Will H
J Cell Biol. 1997
PubMed ID: 9412458
Stable overexpression of PML alters regulation of cell cycle progression in HeLa cells.
Mu ZM, Le XF, Vallian S, Glassman AB, Chang KS
Carcinogenesis. 1997
PubMed ID: 9395203
Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies.
Koken MH, Reid A, Quignon F, Chelbi-Alix MK, Davies JM, Kabarowski JH, Zhu J, Dong S, Chen S, Chen Z, Tan CC, Licht J, Waxman S, de Thé H, Zelent A
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9294197
Cellular localization, expression, and structure of the nuclear dot protein 52.
Sternsdorf T, Jensen K, Züchner D, Will H
J Cell Biol. 1997
PubMed ID: 9230084
Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice.
He LZ, Tribioli C, Rivi R, Peruzzi D, Pelicci PG, Soares V, Cattoretti G, Pandolfi PP
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9144232
PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.
Boddy MN, Howe K, Etkin LD, Solomon E, Freemont PS
Oncogene. 1996
PubMed ID: 8806687
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Transgenic expression of PML/RARalpha impairs myelopoiesis.
Early E, Moore MA, Kakizuka A, Nason-Burchenal K, Martin P, Evans RM, Dmitrovsky E
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8755574
In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML.
Borden KL, Lally JM, Martin SR, O'Reilly NJ, Solomon E, Freemont PS
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8643677
Cloning of the murine homolog of the leukemia-associated PML gene.
Goddard AD, Yuan JQ, Fairbairn L, Dexter M, Borrow J, Kozak C, Solomon E
Mamm Genome. 1995
PubMed ID: 8563172
The PML gene encodes a phosphoprotein associated with the nuclear matrix.
Chang KS, Fan YH, Andreeff M, Liu J, Mu ZM
Blood. 1995
PubMed ID: 7780148
The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML.
Borden KL, Boddy MN, Lally J, O'Reilly NJ, Martin S, Howe K, Solomon E, Freemont PS
EMBO J. 1995
PubMed ID: 7729428
PML, a growth suppressor disrupted in acute promyelocytic leukemia.
Mu ZM, Chin KV, Liu JH, Lozano G, Chang KS
Mol Cell Biol. 1994
PubMed ID: 7935403
Molecular study on the chromosome 15 breakpoints in the translocation t(15; 17) in acute promyelocytic leukemia (APL).
Dong S, Tong JH, Huang W, Chen SJ, Chen Z, Wang ZY, Geng JP, Qi ZW
Sci China B. 1993
PubMed ID: 8274203
The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells.
Grignani F, Ferrucci PF, Testa U, Talamo G, Fagioli M, Alcalay M, Mencarelli A, Grignani F, Peschle C, Nicoletti I
Cell. 1993
PubMed ID: 8394219
Localization of the chromosome 15 breakpoints and expression of multiple PML-RAR alpha transcripts in acute promyelocytic leukemia: a study of 28 Chinese patients.
Geng JP, Tong JH, Dong S, Wang ZY, Chen SJ, Chen Z, Zelent A, Berger R, Larsen CJ
Leukemia. 1993
PubMed ID: 8380300
Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.
Fagioli M, Alcalay M, Pandolfi PP, Venturini L, Mencarelli A, Simeone A, Acampora D, Grignani F, Pelicci PG
Oncogene. 1992
PubMed ID: 1594241
Molecular rearrangements of the MYL gene in acute promyelocytic leukemia (APL, M3) define a breakpoint cluster region as well as some molecular variants.
Tong JH, Dong S, Geng JP, Huang W, Wang ZY, Sun GL, Chen SJ, Chen Z, Larsen CJ, Berger R
Oncogene. 1992
PubMed ID: 1312695
Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.
Kastner P, Perez A, Lutz Y, Rochette-Egly C, Gaub MP, Durand B, Lanotte M, Berger R, Chambon P
EMBO J. 1992
PubMed ID: 1311253
Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia.
Goddard AD, Borrow J, Freemont PS, Solomon E
Science. 1991
PubMed ID: 1720570
The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR.
de Thé H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A
Cell. 1991
PubMed ID: 1652369
Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML.
Kakizuka A, Miller WH, Umesono K, Warrell RP, Frankel SR, Murty VV, Dmitrovsky E, Evans RM
Cell. 1991
PubMed ID: 1652368
[The laboratory in programs for enteric infection control]
Grados OB
Bol Oficina Sanit Panam. 1975
PubMed ID: 123456

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	5371	18854	315713
EnsEMBL Gene(s)	ENSG00000140464	ENSMUSG00000036986	ENSRNOG00000008400
Unigene	Hs.526464	Mm.392123	Rn.214058
Homologene	PML	Pml	Pml
OMIM	102578	N/A	N/A
GeneCards	PML	N/A	N/A
Beta Cell Genomics	DT.100792857 DT.100792858 DT.100792859 DT.100792863 DT.100792875 DT.102827730 DT.210086 DT.317724 DT.447813 DT.91783610 DT.91792314 DT.91836290 DT.92352534 DT.97772804 DT.97787374 DT.97791923	DT.101343246 DT.101404898 DT.101404905 DT.110598933 DT.531781 DT.55218027 DT.55230140 DT.91291330 DT.94225846 DT.99853345	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	5371	18854	315713

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
PML	MED16	BioGRID	empirical	20211142
PML	SAP25	IntAct, BioGRID	empirical	16449650
PML	CDK2	IntAct	empirical	21840486
PML	CDK6	IntAct	empirical	21840486
PML	CDKN2A	IntAct	empirical	12740913
PML	KAT5	BioGRID	empirical	19150978
PML	TOPBP1	HPRD, BioGRID	empirical	12773567
PML	CHD4	BioGRID	empirical	18644863
PML	ADH1B	IntAct	empirical	21988832
PML	ATF2	BioGRID	empirical	9671405
PML	CREBBP	HPRD, BioGRID	empirical	10077561 12142048 12622724 10610177 12234245
PML	TRIM69	HPRD, BioGRID	empirical	12837286
PML	MAPK14	HPRD	empirical	15273249
PML	CSNK2A1	HPRD, IntAct	empirical	16873060
PML	UBE2U	IntAct, BioGRID	empirical	19690564
PML	DAXX	HPRD, IntAct, MIPS, BioGRID	empirical	10684855 10669754 10525530 12595526 15350595 14517282 12529400 21840486 11244500 21779164 20972456
PML	ARID3A	HPRD	empirical	15017387
PML	EIF4E	HPRD, BioGRID	empirical	11500381
PML	ELF4	HPRD	empirical	14976184
PML	EP300	HPRD	empirical	11940591
PML	HIPK1	IntAct	empirical	12529400
PML	EZH2	IntAct	empirical	17560333
PML	PAXIP1	HPRD	empirical	11940591
PML	FOXO1	BioGRID	empirical	16154098
PML	SIRT1	IntAct	empirical	12006491
PML	SUZ12	IntAct	empirical	17560333
PML	FOS	BioGRID	empirical	9671405
PML	SSBP2	IntAct	empirical	20540776
PML	MTOR	BioGRID	empirical	16915281
PML	SIN3A	HPRD, BioGRID	empirical	11430826
PML	SENP6	BioGRID	empirical	21148299
PML	GATA2	HPRD, BioGRID	empirical	10938104
PML	ANKRD2	HPRD, BioGRID	empirical	15136035
PML	KLHL20	IntAct, BioGRID	empirical	21840486 20389280
PML	HIPK2	IntAct, BioGRID	empirical	21057547
PML	NR3C1	BioGRID	empirical	20211142
PML	GTF2E1	BioGRID	empirical	20211142
PML	GTF2E2	BioGRID	empirical	20211142
PML	HDAC1	HPRD, BioGRID	empirical	11430826 11259576 18644863
PML	HDAC2	HPRD, BioGRID	empirical	11259576 18644863 18454139 18073335
PML	HHEX	HPRD, BioGRID	empirical	10597310
PML	NR4A1	HPRD, BioGRID	empirical	12032831
PML	HNRNPU	BioGRID	empirical	18212063
PML	EIF3E	IntAct	empirical	10504338
PML	JUN	BioGRID	empirical	9671405
PML	ARNT	HPRD, BioGRID	empirical	12354770
PML	MXD1	HPRD	empirical	11430826
PML	SMAD2	BioGRID	empirical	15356634
PML	SMAD3	HPRD, BioGRID	empirical	15356634
PML	MDM2	HPRD, MINT, IntAct, BioGRID	empirical	14507915 15195100 12915590 12759344 19150978 20972456
PML	ZNF506	BioGRID	empirical	16412420
PML	MYB	HPRD, IntAct, BioGRID	empirical	15194430 20802522
PML	MYC	HPRD, IntAct	empirical	15735755 21150319
PML	NFKB1	IntAct	empirical	21988832
PML	NPM1	BioGRID	empirical	18212063
PML	PAWR	HPRD	empirical	12717420
PML	HDAC7	BioGRID	empirical	18463162
PML	PIN1	IntAct	empirical	21840486
PML	PLAGL1	BioGRID	empirical	20097304
PML	PLSCR1	IntAct	empirical	21988832
PML	PML	HPRD, IntAct, BioGRID	empirical	12837286 9294197 10938104 9671498 10669754 20211142
PML	POLR2E	BioGRID	empirical	20211142
PML	POU5F1	BioGRID	empirical	20362541
PML	BANP	BioGRID	empirical	20075864
PML	CHFR	HPRD, BioGRID	empirical	15467728
PML	MAPK7	IntAct	empirical	20832753
PML	MAPK11	BioGRID	empirical	15273249
PML	PSMA3	IntAct	empirical	21988832
PML	RARA	HPRD, BioGRID	empirical	12935927 1311253 10610177 10882117 18073335 20159610
PML	RB1	HPRD, BioGRID	empirical	9448006
PML	SENP2	HPRD, BioGRID	empirical	12419228
PML	BCL2	HPRD	empirical	15231068
PML	RELA	HPRD, BioGRID	empirical	12540841
PML	RFC4	BioGRID	empirical	18212063
PML	TRIM27	HPRD, BioGRID	empirical	9570750
PML	RPL11	HPRD, BioGRID	empirical	15195100
PML	RXRA	BioGRID	empirical	10610177
PML	SATB1	BioGRID	empirical	17173041
PML	SH3GL1	IntAct	empirical	21988832
PML	SIAH1	BioGRID	empirical	18073335
PML	SKI	HPRD, BioGRID	empirical	11430826
PML	SMARCA4	BioGRID	empirical	21360626
PML	SUMO3	HPRD, IntAct, BioGRID	empirical	15576338 17000644 21779164 22082260
PML	SUMO2	HPRD	empirical	9452416
PML	SP1	HPRD, BioGRID	empirical	9819401 21360626
PML	SP100	BioGRID	empirical	21779164 21172801
PML	SPI1	BioGRID	empirical	20159610
PML	SRF	HPRD, BioGRID	empirical	12622724
PML	STAT3	HPRD, BioGRID	empirical	12506013
PML	AURKA	HPRD	empirical	15749021
PML	SUV39H1	HPRD, IntAct	empirical	16449642
PML	TDG	HPRD, BioGRID	empirical	15569683
PML	TERT	BioGRID	empirical	19567472
PML	TGFBR1	HPRD	empirical	15356634
PML	TGFBR2	HPRD	empirical	15356634
PML	TGIF1	HPRD, MINT, BioGRID	empirical	18511908
PML	THRA	HPRD	empirical	10610177
PML	TOP2B	BioGRID	empirical	18212063
PML	TOP3A	MINT	empirical	18418389
PML	TP53	HPRD, MINT, IntAct, BioGRID	empirical	11704853 11025664 11080164 12915590 21057547 12006491 14976551 20972456
PML	TP73	HPRD	empirical	11832207
PML	NR2C1	BioGRID	empirical	19204783 21360626
PML	UBC	BioGRID	empirical	18708055 19325566 21139048 21890473 21906983
PML	UBE2I	IntAct, BioGRID	empirical	21988832 18691969
PML	UBE3A	BioGRID	empirical	19325566
PML	SUMO1	HPRD, MINT, IntAct	empirical	8806687 11080164 11948183 9756909 17036045 21057547
PML	SF1	BioGRID	empirical	21360626
PML	ZSCAN21	BioGRID	empirical	20211142
PML	ZBTB16	HPRD, IntAct, BioGRID	empirical	9294197 11175338
PML	SAP130	BioGRID	empirical	18212063
PML	NANOG	BioGRID	empirical	18454139
PML	AXIN1	IntAct, BioGRID	empirical	21057547
PML	PCBD2	BioGRID	empirical	20211142
PML	CUL3	IntAct	empirical	21840486
PML	RUNX1	BioGRID	empirical	18073335
PML	TRIM24	HPRD, BioGRID	empirical	10610177
PML	HDAC3	HPRD, BioGRID	empirical	11259576
PML	CCNT1	HPRD, BioGRID	empirical	12727882
PML	MLIP	IntAct	empirical	21498514
PML	ZFYVE9	HPRD, MINT, BioGRID	empirical	15356634 18511908
PML	SNRNP40	BioGRID	empirical	18212063
PML	MED17	BioGRID	empirical	20211142
PML	MED7	BioGRID	empirical	20211142
PML	NCOR1	HPRD, BioGRID	empirical	11430826 10882117
PML	NCOR2	HPRD	empirical	11585900
PML	CDK1	IntAct	empirical	21840486
PML	CASP8AP2	IntAct	empirical	21988832