MBD3

Summary Top Help

Gene Description:

methyl-CpG binding domain protein 3

Synonyms:

AI181826, AU019209, MBD3, Mbd3

Orthologs:

Human MBD3 (protein-coding), Mouse Mbd3 (protein-coding), Rat Mbd3 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr19:1576677..1592710 (163 kb) View in Genome Browser

(Mouse) NCBIM37 - chr10:79855284..79862295 (71 kb) View in Genome Browser

(Rat) RGSC3.4 - chr7:10824260..10831460 (7.20 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for MBD3:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
								no data	no data	no data	no data	no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for MBD3:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: 1

Reactome: None available

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 14

Publications from PubMed Top Help

Publications: 86

Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells.
Yildirim O, Li R, Hung JH, Chen PB, Dong X, Ee LS, Weng Z, Rando OJ, Fazzio TG
Cell. 2011
PubMed ID: 22196727
c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex.
Aguilera C, Nakagawa K, Sancho R, Chakraborty A, Hendrich B, Behrens A
Nature. 2011
PubMed ID: 21196933
Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA
PLoS One. 2011
PubMed ID: 21731673
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Phosphorylated p68 RNA helicase activates Snail1 transcription by promoting HDAC1 dissociation from the Snail1 promoter.
Carter CL, Lin C, Liu CY, Yang L, Liu ZR
Oncogene. 2010
PubMed ID: 20676135
CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex.
Spruijt CG, Bartels SJ, Brinkman AB, Tjeertes JV, Poser I, Stunnenberg HG, Vermeulen M
Mol Biosyst. 2010
PubMed ID: 20523938
Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells.
Van Rechem C, Boulay G, Pinte S, Stankovic-Valentin N, Guérardel C, Leprince D
Mol Cell Biol. 2010
PubMed ID: 20547755
Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes.
Adenuga D, Rahman I
Arch Biochem Biophys. 2010
PubMed ID: 20388487
An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.
Pardo M, Lang B, Yu L, Prosser H, Bradley A, Babu MM, Choudhary J
Cell Stem Cell. 2010
PubMed ID: 20362542
An Oct4-centered protein interaction network in embryonic stem cells.
van den Berg DL, Snoek T, Mullin NP, Yates A, Bezstarosti K, Demmers J, Chambers I, Poot RA
Cell Stem Cell. 2010
PubMed ID: 20362541
Increased interaction between DJ-1 and the Mi-2/ nucleosome remodelling and deacetylase complex during cellular stress.
Opsahl JA, Hjørnevik LV, Bull VH, Fismen L, Frøyset AK, Gromyko D, Solstad T, Fladmark KE
Proteomics. 2010
PubMed ID: 20127688
Single cell RT-PCR on mouse embryos: a general approach for developmental biology.
Mann W, Haaf T
Methods Mol Biol. 2010
PubMed ID: 20300987
MBD3 mutations are not responsible for ICR1 hypomethylation in Silver-Russell syndrome.
Bachmann N, Spengler S, Binder G, Eggermann T
Eur J Med Genet. 2010
PubMed ID: 20004753
Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity.
Katryniok C, Schnur N, Gillis A, von Knethen A, Sorg BL, Looijenga L, Rådmark O, Steinhilber D
Biochim Biophys Acta. 2010
PubMed ID: 19781662
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
Nishiyama A, Xin L, Sharov AA, Thomas M, Mowrer G, Meyers E, Piao Y, Mehta S, Yee S, Nakatake Y, Stagg C, Sharova L, Correa-Cerro LS, Bassey U, Hoang H, Kim E, Tapnio R, Qian Y, Dudekula D, Zalzman M, Li M, Falco G, Yang HT, Lee SL, Monti M, Stanghellini I, Islam MN, Nagaraja R, Goldberg I, Wang W, Longo DL, Schlessinger D, Ko MS
Cell Stem Cell. 2009
PubMed ID: 19796622
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer.
Wang Y, Zhang H, Chen Y, Sun Y, Yang F, Yu W, Liang J, Sun L, Yang X, Shi L, Li R, Li Y, Zhang Y, Li Q, Yi X, Shang Y
Cell. 2009
PubMed ID: 19703393
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Cdk2ap1 is required for epigenetic silencing of Oct4 during murine embryonic stem cell differentiation.
Deshpande AM, Dai YS, Kim Y, Kim J, Kimlin L, Gao K, Wong DT
J Biol Chem. 2009
PubMed ID: 19117947
A novel role for methyl CpG-binding domain protein 3, a component of the histone deacetylase complex, in regulation of cell cycle progression and cell death.
Noh EJ, Lim DS, Lee JS
Biochem Biophys Res Commun. 2009
PubMed ID: 19041848
Mbd3, a component of NuRD/Mi-2 complex, helps maintain pluripotency of mouse embryonic stem cells by repressing trophectoderm differentiation.
Zhu D, Fang J, Li Y, Zhang J
PLoS One. 2009
PubMed ID: 19888462
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
In vitro nuclear interactome of the HIV-1 Tat protein.
Gautier VW, Gu L, O'Donoghue N, Pennington S, Sheehy N, Hall WW
Retrovirology. 2009
PubMed ID: 19454010
Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres.
May A, Kirchner R, Müller H, Hartmann P, El Hajj N, Tresch A, Zechner U, Mann W, Haaf T
Biol Reprod. 2009
PubMed ID: 18784354
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.
Morey L, Brenner C, Fazi F, Villa R, Gutierrez A, Buschbeck M, Nervi C, Minucci S, Fuks F, Di Croce L
Mol Cell Biol. 2008
PubMed ID: 18644863
DNA demethylation induced by the methyl-CpG-binding domain protein MBD3.
Brown SE, Suderman MJ, Hallett M, Szyf M
Gene. 2008
PubMed ID: 18602768
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Myeloid transforming protein Evi1 interacts with methyl-CpG binding domain protein 3 and inhibits in vitro histone deacetylation by Mbd3/Mi-2/NuRD.
Spensberger D, Vermeulen M, Le Guezennec X, Beekman R, van Hoven A, Bindels E, Stunnenberg H, Delwel R
Biochemistry. 2008
PubMed ID: 18500823
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells.
Liang J, Wan M, Zhang Y, Gu P, Xin H, Jung SY, Qin J, Wong J, Cooney AJ, Liu D, Songyang Z
Nat Cell Biol. 2008
PubMed ID: 18454139
Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development.
Ruddock-D'Cruz NT, Xue J, Wilson KJ, Heffernan C, Prashadkumar S, Cooney MA, Sanchez-Partida LG, French AJ, Holland MK
Mol Reprod Dev. 2008
PubMed ID: 17546630
Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin.
Sun JM, Chen HY, Davie JR
J Biol Chem. 2007
PubMed ID: 17827154
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.
Sillibourne JE, Delaval B, Redick S, Sinha M, Doxsey SJ
Mol Biol Cell. 2007
PubMed ID: 17626165
Maintenance of paternal methylation and repression of the imprinted H19 gene requires MBD3.
Reese KJ, Lin S, Verona RI, Schultz RM, Bartolomei MS
PLoS Genet. 2007
PubMed ID: 17708683
Epigenetic programming of the rRNA promoter by MBD3.
Brown SE, Szyf M
Mol Cell Biol. 2007
PubMed ID: 17452452
Identification of a murine methyl cytosine phosphate guanine binding domain-containing factor 3 (MBD3) promoter segment sufficient for driving reporter gene expression in neurons in vitro and in vivo.
Jung BP, Purushotham D, Eubanks JH
Neuroscience. 2007
PubMed ID: 17289276
Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.
Kaji K, Nichols J, Hendrich B
Development. 2007
PubMed ID: 17287250
RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression.
Fukushige S, Kondo E, Gu Z, Suzuki H, Horii A
Biochem Biophys Res Commun. 2006
PubMed ID: 17049487
SUMO modification enhances p66-mediated transcriptional repression of the Mi-2/NuRD complex.
Gong Z, Brackertz M, Renkawitz R
Mol Cell Biol. 2006
PubMed ID: 16738318
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
The NuRD component Mbd3 is required for pluripotency of embryonic stem cells.
Kaji K, Caballero IM, MacLeod R, Nichols J, Wilson VA, Hendrich B
Nat Cell Biol. 2006
PubMed ID: 16462733
MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.
Le Guezennec X, Vermeulen M, Brinkman AB, Hoeijmakers WA, Cohen A, Lasonder E, Stunnenberg HG
Mol Cell Biol. 2006
PubMed ID: 16428440
Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.
McCracken S, Longman D, Marcon E, Moens P, Downey M, Nickerson JA, Jessberger R, Wilde A, Caceres JF, Emili A, Blencowe BJ
J Biol Chem. 2005
PubMed ID: 16159877
Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells.
Datta J, Majumder S, Bai S, Ghoshal K, Kutay H, Smith DS, Crabb JW, Jacob ST
Cancer Res. 2005
PubMed ID: 16322236
BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter.
Cismasiu VB, Adamo K, Gecewicz J, Duque J, Lin Q, Avram D
Oncogene. 2005
PubMed ID: 16091750
GATA-1 forms distinct activating and repressive complexes in erythroid cells.
Rodriguez P, Bonte E, Krijgsveld J, Kolodziej KE, Guyot B, Heck AJ, Vyas P, de Boer E, Grosveld F, Strouboulis J
EMBO J. 2005
PubMed ID: 15920471
MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.
Jin SG, Jiang CL, Rauch T, Li H, Pfeifer GP
J Biol Chem. 2005
PubMed ID: 15701600
MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex.
Jiang CL, Jin SG, Pfeifer GP
J Biol Chem. 2004
PubMed ID: 15456747
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.
Fujita N, Jaye DL, Geigerman C, Akyildiz A, Mooney MR, Boss JM, Wade PA
Cell. 2004
PubMed ID: 15454082
The DNA sequence and biology of human chromosome 19.
Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM
Nature. 2004
PubMed ID: 15057824
Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression.
Ghoshal K, Majumder S, Datta J, Motiwala T, Bai S, Sharma SM, Frankel W, Jacob ST
J Biol Chem. 2004
PubMed ID: 14610093
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo.
Kantor B, Makedonski K, Shemer R, Razin A
Gene Expr Patterns. 2003
PubMed ID: 14643676
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse.
Percec I, Thorvaldsen JL, Plenge RM, Krapp CJ, Nadeau JH, Willard HF, Bartolomei MS
Genetics. 2003
PubMed ID: 12930754
Differential expression of methyl CpG-binding domain containing factor MBD3 in the developing and adult rat brain.
Jung BP, Zhang G, Nitsch R, Trogadis J, Nag S, Eubanks JH
J Neurobiol. 2003
PubMed ID: 12672019
MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer.
Fujita N, Jaye DL, Kajita M, Geigerman C, Moreno CS, Wade PA
Cell. 2003
PubMed ID: 12705869
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase.
Sakai H, Urano T, Ookata K, Kim MH, Hirai Y, Saito M, Nojima Y, Ishikawa F
J Biol Chem. 2002
PubMed ID: 12354758
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.
Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E
Mol Cell. 2002
PubMed ID: 12453419
Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3.
Brackertz M, Boeke J, Zhang R, Renkawitz R
J Biol Chem. 2002
PubMed ID: 12183469
The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.
Saito M, Ishikawa F
J Biol Chem. 2002
PubMed ID: 12124384
Expression of the genes of methyl-binding domain proteins in human gliomas.
Schlegel J, Güneysu S, Mennel HD
Oncol Rep. 2002
PubMed ID: 11836615
Identification and functional characterization of the p66/p68 components of the MeCP1 complex.
Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y
Mol Cell Biol. 2002
PubMed ID: 11756549
Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA.
Ohki I, Shimotake N, Fujita N, Jee J, Ikegami T, Nakao M, Shirakawa M
Cell. 2001
PubMed ID: 11371345
Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities.
Pires-daSilva A, Nayernia K, Engel W, Torres M, Stoykova A, Chowdhury K, Gruss P
Dev Biol. 2001
PubMed ID: 11336498
Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.
Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM
Genes Dev. 2001
PubMed ID: 11331609
The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes.
Feng Q, Zhang Y
Genes Dev. 2001
PubMed ID: 11297506
Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development.
Hendrich B, Guy J, Ramsahoye B, Wilson VA, Bird A
Genes Dev. 2001
PubMed ID: 11274056
Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.
Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH
J Biol Chem. 2001
PubMed ID: 11102443
MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase.
Tatematsu KI, Yamazaki T, Ishikawa F
Genes Cells. 2000
PubMed ID: 10947852
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation.
Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP
Nat Genet. 1999
PubMed ID: 10471500
Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes.
Hendrich B, Abbott C, McQueen H, Chambers D, Cross S, Bird A
Mamm Genome. 1999
PubMed ID: 10441743
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D
Genes Dev. 1999
PubMed ID: 10444591
Identification and characterization of a family of mammalian methyl-CpG binding proteins.
Hendrich B, Bird A
Mol Cell Biol. 1998
PubMed ID: 9774669
Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.
Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL
Nature. 1998
PubMed ID: 9804427
The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.
Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D
Cell. 1998
PubMed ID: 9790534
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Soluble bovine galactose-binding lectin. cDNA cloning reveals the complete amino acid sequence and an antigenic relationship with the major encephalitogenic domain of myelin basic protein.
Abbott WM, Mellor A, Edwards Y, Feizi T
Biochem J. 1989
PubMed ID: 2470348

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	53615	17192	362834
EnsEMBL Gene(s)	ENSG00000071655	ENSMUSG00000035478	N/A
Unigene	Hs.178728	Mm.7142	Rn.1737
Homologene	MBD3	Mbd3	Mbd3
OMIM	603573	N/A	N/A
GeneCards	MBD3	N/A	N/A
Beta Cell Genomics	DT.100034143 DT.100819817 DT.100819819 DT.101978021 DT.65284492	DT.536024 DT.91352771	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	53615	17192	362834

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
MBD3	ALL1	BioGRID	empirical	12453419
MBD3	CHD4	BioGRID	empirical	12354758
MBD3	PARK7	IntAct, BioGRID	empirical	20127688
MBD3	MBD3L2	BioGRID	empirical	15701600
MBD3	DDX5	IntAct, BioGRID	empirical	20676135
MBD3	DNMT3A	BioGRID	empirical	16322236
MBD3	ESRRB	BioGRID	empirical	20362541
MBD3	MECOM	IntAct, BioGRID	empirical	18500823
MBD3	SPEN	HPRD	empirical	11331609
MBD3	KDM1A	IntAct, BioGRID	empirical	19703393
MBD3	SRRM2	BioGRID	empirical	16159877
MBD3	SIN3A	BioGRID	empirical	12453419
MBD3	APPL1	IntAct	empirical	15016378
MBD3	GATA1	BioGRID	empirical	15920471
MBD3	TFCP2L1	BioGRID	empirical	20362541
MBD3	HDAC1	HPRD, IntAct, BioGRID	empirical	12124384 21258344 12354758 10444591 19041848 16428440 11102443 17827154
MBD3	HDAC2	IntAct, BioGRID	empirical	18500823 21258344 12354758 19041848 18454139 17827154 20388487
MBD3	HIC1	BioGRID	empirical	20547755
MBD3	JUN	BioGRID	empirical	21196933
MBD3	PCNT	BioGRID	empirical	17626165
MBD3	TRIM33	IntAct	empirical	20603019
MBD3	BCL11A	BioGRID	empirical	16091750
MBD3	MBD3	HPRD, BioGRID	empirical	12183469 15456747 10947852 15701600
MBD3	POU5F1	IntAct, BioGRID	empirical	20362542 20362541 18454139
MBD3	GATAD2A	HPRD, BioGRID	empirical	12183469 16738318
MBD3	SALL4	BioGRID	empirical	20362541
MBD3	GATAD2B	HPRD, BioGRID	empirical	12183469 11756549 16738318
MBD3	MTA3	IntAct, BioGRID	empirical	21258344 12705869
MBD3	RBBP4	HPRD, BioGRID	empirical	10444591
MBD3	RBBP7	HPRD, IntAct, BioGRID	empirical	10444591 18500823
MBD3	TRIM27	BioGRID	empirical	17049487
MBD3	SMARCA2	BioGRID	empirical	12453419
MBD3	SMARCA4	BioGRID	empirical	16322236 22196727
MBD3	SOX2	BioGRID	empirical	21532573
MBD3	AURKA	HPRD, BioGRID	empirical	12354758
MBD3	TAF6	BioGRID	empirical	12453419
MBD3	UBC	BioGRID	empirical	21139048 21890473
MBD3	NANOG	BioGRID	empirical	18454139
MBD3	TET1	BioGRID	empirical	22196727
MBD3	CDK2AP1	BioGRID	empirical	20523938
MBD3	MBD3L1	HPRD, BioGRID	empirical	15456747
MBD3	MBD2	HPRD, BioGRID	empirical	10947852 15456747 10444591 15701600 11297506
MBD3	MTA1	BioGRID	empirical	18454139 22196727
MBD3	MTA2	HPRD, IntAct, BioGRID	empirical	12124384 18500823 19703393 12354758 10444591 20362541 18454139 15920471 11297506