PLG

Summary Top Help

Gene Description:

plasminogen

Synonyms:

Pg, PLG, Ab1-346, Plg, AI649309

Orthologs:

Human PLG (protein-coding), Mouse Plg (protein-coding), Rat Plg (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd23	Mouse	chr17:3924615..26319104	22.39	376

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr6:161123225..161175086 (51.86 kb) View in Genome Browser

(Mouse) NCBIM37 - chr17:12571475..12612250 (40.77 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:42782464..42825152 (42.69 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PLG:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PLG:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 4

Biocarta: 3

Reactome: 9

NCI-Nature Pathway Interaction Database: 5

Gene Ontology: 23

Publications from PubMed Top Help

Publications: 430

Haemophilus influenzae uses the surface protein E to acquire human plasminogen and to evade innate immunity.
Barthel D, Singh B, Riesbeck K, Zipfel PF
J Immunol. 2012
PubMed ID: 22124123
Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation.
Chuang YC, Lei HY, Lin YS, Liu HS, Wu HL, Yeh TM
J Immunol. 2011
PubMed ID: 22079981
Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT.
Lighvani S, Baik N, Diggs JE, Khaldoyanidi S, Parmer RJ, Miles LA
Blood. 2011
PubMed ID: 21940822
In vitro evidence for immune evasion activity by human plasmin associated to pathogenic Leptospira interrogans.
Vieira ML, de Morais ZM, Vasconcellos SA, Romero EC, Nascimento AL
Microb Pathog. 2011
PubMed ID: 21802507
Plasminogen regulates stromal cell-derived factor-1/CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9.
Gong Y, Fan Y, Hoover-Plow J
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21719761
Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen.
Han J, Baik N, Kim KH, Yang JM, Han GW, Gong Y, Jardí M, Castellino FJ, Felez J, Parmer RJ, Miles LA
Blood. 2011
PubMed ID: 21680799
Plasmin is essential in preventing periodontitis in mice.
Sulniute R, Lindh T, Wilczynska M, Li J, Ny T
Am J Pathol. 2011
PubMed ID: 21704601
Contribution of conserved lysine residues in the alpha2-antiplasmin C terminus to plasmin binding and inhibition.
Lu BG, Sofian T, Law RH, Coughlin PB, Horvath AJ
J Biol Chem. 2011
PubMed ID: 21543325
Intermolecular interactions in staphylokinase-plasmin(ogen) bimolecular complex: function of His43 and Tyr44.
Dahiya M, Singh S, Rajamohan G, Sethi D, Ashish, Dikshit KL
FEBS Lett. 2011
PubMed ID: 21510941
Kinetics of activated thrombin-activatable fibrinolysis inhibitor (TAFIa)-catalyzed cleavage of C-terminal lysine residues of fibrin degradation products and removal of plasminogen-binding sites.
Foley JH, Cook PF, Nesheim ME
J Biol Chem. 2011
PubMed ID: 21467042
Extra-embryonic-specific imprinted expression is restricted to defined lineages in the post-implantation embryo.
Hudson QJ, Seidl CI, Kulinski TM, Huang R, Warczok KE, Bittner R, Bartolomei MS, Barlow DP
Dev Biol. 2011
PubMed ID: 21354127
Feedback regulation of endothelial cell surface plasmin generation by PKC-dependent phosphorylation of annexin A2.
He KL, Sui G, Xiong H, Broekman MJ, Huang B, Marcus AJ, Hajjar KA
J Biol Chem. 2011
PubMed ID: 21115493
Simultaneous thrombin and plasmin generation capacities in normal and abnormal states of coagulation and fibrinolysis in children and adults.
Simpson ML, Goldenberg NA, Jacobson LJ, Bombardier CG, Hathaway WE, Manco-Johnson MJ
Thromb Res. 2011
PubMed ID: 21316746
Differential expression of oxidized/native lipoprotein(a) and plasminogen in human carotid and cerebral artery plaques.
Umahara T, Uchihara T, Yamada S, Hashimoto T, Akimoto J, Haraoka J, Iwamoto T
Atherosclerosis. 2011
PubMed ID: 21300353
Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation.
Madoiwa S, Tanaka H, Nagahama Y, Dokai M, Kashiwakura Y, Ishiwata A, Sakata A, Yasumoto A, Ohmori T, Mimuro J, Sakata Y
Thromb Res. 2011
PubMed ID: 21236472
Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation.
Leksa V, Loewe R, Binder B, Schiller HB, Eckerstorfer P, Forster F, Soler-Cardona A, Ondrovicová G, Kutejová E, Steinhuber E, Breuss J, Drach J, Petzelbauer P, Binder BR, Stockinger H
Circ Res. 2011
PubMed ID: 21273553
Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function.
Kanno Y, Ishisaki A, Kawashita E, Chosa N, Nakajima K, Nishihara T, Toyoshima K, Okada K, Ueshima S, Matsushita K, Matsuo O, Matsuno H
J Biol Chem. 2011
PubMed ID: 21239499
Identification of three novel plasminogen (PLG) gene mutations in a series of 23 patients with low PLG activity.
Klammt J, Kobelt L, Aktas D, Durak I, Gokbuget A, Hughes Q, Irkec M, Kurtulus I, Lapi E, Mechoulam H, Mendoza-Londono R, Palumbo JS, Steitzer H, Tabbara KF, Ozbek Z, Pucci N, Sotomayor T, Sturm M, Drogies T, Ziegler M, Schuster V
Thromb Haemost. 2011
PubMed ID: 21174000
Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus.
Taniguchi Y, Inoue N, Morita S, Nikaido Y, Nakashima T, Nagai N, Okada K, Matsuo O, Miyata S
Cell Tissue Res. 2011
PubMed ID: 21190118
Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice.
Guo Y, Li J, Hagström E, Ny T
PLoS One. 2011
PubMed ID: 21931850
Potential role of serine proteases in modulating renal sodium transport in vivo.
Jacquillet G, Rubera I, Unwin RJ
Nephron Physiol. 2011
PubMed ID: 21832858
Matrix metalloproteinase-19 inhibits growth of endothelial cells by generating angiostatin-like fragments from plasminogen.
Brauer R, Beck IM, Roderfeld M, Roeb E, Sedlacek R
BMC Biochem. 2011
PubMed ID: 21787393
Characterization of novel OmpA-like protein of Leptospira interrogans that binds extracellular matrix molecules and plasminogen.
Oliveira R, de Morais ZM, Gonçales AP, Romero EC, Vasconcellos SA, Nascimento AL
PLoS One. 2011
PubMed ID: 21755014
Bacillus anthracis interacts with plasmin(ogen) to evade C3b-dependent innate immunity.
Chung MC, Tonry JH, Narayanan A, Manes NP, Mackie RS, Gutting B, Mukherjee DV, Popova TG, Kashanchi F, Bailey CL, Popov SG
PLoS One. 2011
PubMed ID: 21464960
Phenotypic overlap between MMP-13 and the plasminogen activation system during wound healing in mice.
Juncker-Jensen A, Lund LR
PLoS One. 2011
PubMed ID: 21326869
Plasmin plays an essential role in amplification of psoriasiform skin inflammation in mice.
Li Q, Ke F, Zhang W, Shen X, Xu Q, Wang H, Yu XZ, Leng Q, Wang H
PLoS One. 2011
PubMed ID: 21311769
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Plasminogen promotes influenza A virus replication through an annexin 2-dependent pathway in the absence of neuraminidase.
LeBouder F, Lina B, Rimmelzwaan GF, Riteau B
J Gen Virol. 2010
PubMed ID: 20702651
Plasminogen and plasmin in Alzheimer's disease.
Barker R, Love S, Kehoe PG
Brain Res. 2010
PubMed ID: 20709033
Activation of plasminogen by staphylokinase reduces the severity of Staphylococcus aureus systemic infection.
Kwieciński J, Josefsson E, Mitchell J, Higgins J, Magnusson M, Foster T, Jin T, Bokarewa M
J Infect Dis. 2010
PubMed ID: 20726765
The generation and characterization of mice expressing a plasmin-inactivating active site mutation.
Iwaki T, Malinverno C, Smith D, Xu Z, Liang Z, Ploplis VA, Castellino FJ
J Thromb Haemost. 2010
PubMed ID: 20653841
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Human plasminogen kringle 3: solution structure, functional insights, phylogenetic landscape.
Christen MT, Frank P, Schaller J, Llinás M
Biochemistry. 2010
PubMed ID: 20617841
Complement regulator-acquiring surface protein 1 of Borrelia burgdorferi binds to human bone morphogenic protein 2, several extracellular matrix proteins, and plasminogen.
Hallström T, Haupt K, Kraiczy P, Hortschansky P, Wallich R, Skerka C, Zipfel PF
J Infect Dis. 2010
PubMed ID: 20565259
Skin wound healing in MMP2-deficient and MMP2 / plasminogen double-deficient mice.
Frøssing S, Rønø B, Hald A, Rømer J, Lund LR
Exp Dermatol. 2010
PubMed ID: 20163454
NMR backbone dynamics of VEK-30 bound to the human plasminogen kringle 2 domain.
Wang M, Prorok M, Castellino FJ
Biophys J. 2010
PubMed ID: 20655859
Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts.
Edelstein C, Pfaffinger D, Yang M, Hill JS, Scanu AM
Biochim Biophys Acta. 2010
PubMed ID: 20346413
Tissue plasminogen activator and plasminogen are critical for osmotic homeostasis by regulating vasopressin secretion.
Imamura Y, Morita S, Nakatani Y, Okada K, Ueshima S, Matsuo O, Miyata S
J Neurosci Res. 2010
PubMed ID: 20175210
Fibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's disease.
Cortes-Canteli M, Paul J, Norris EH, Bronstein R, Ahn HJ, Zamolodchikov D, Bhuvanendran S, Fenz KM, Strickland S
Neuron. 2010
PubMed ID: 20547128
Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus.
Echeverry R, Wu J, Haile WB, Guzman J, Yepes M
J Clin Invest. 2010
PubMed ID: 20440070
Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM).
Figuera-Losada M, Ranson M, Sanderson-Smith ML, Walker MJ, Castellino FJ, Prorok M
Biochim Biophys Acta. 2010
PubMed ID: 20152941
Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.
Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Heissig B, Hattori K
Blood. 2010
PubMed ID: 20110420
The human alpha(2)-plasmin inhibitor: functional characterization of the unique plasmin(ogen)-binding region.
Gerber SS, Lejon S, Locher M, Schaller J
Cell Mol Life Sci. 2010
PubMed ID: 20112045
Plasminogen on the surfaces of fibrin clots prevents adhesion of leukocytes and platelets.
Lishko VK, Yermolenko IS, Ugarova TP
J Thromb Haemost. 2010
PubMed ID: 20095998
Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.
Roberts KE, Kawut SM, Krowka MJ, Brown RS, Trotter JF, Shah V, Peter I, Tighiouart H, Mitra N, Handorf E, Knowles JA, Zacks S, Fallon MB, Pulmonary Vascular Complications of Liver Disease Study Group
Gastroenterology. 2010
PubMed ID: 20346360
Plasmin triggers chemotaxis of monocyte-derived dendritic cells through an Akt2-dependent pathway and promotes a T-helper type-1 response.
Li X, Syrovets T, Genze F, Pitterle K, Oberhuber A, Orend KH, Simmet T
Arterioscler Thromb Vasc Biol. 2010
PubMed ID: 20056908
The possible mechanism for impaired angiogenesis after transient focal ischemia in type 2 diabetic GK rats: different expressions of angiostatin and vascular endothelial growth factor.
Zhu M, Bi X, Jia Q, Shangguan S
Biomed Pharmacother. 2010
PubMed ID: 19932587
Solution structure of the complex of VEK-30 and plasminogen kringle 2.
Wang M, Zajicek J, Geiger JH, Prorok M, Castellino FJ
J Struct Biol. 2010
PubMed ID: 19800007
Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling.
Hu M, Sun XJ, Zhang YL, Kuang Y, Hu CQ, Wu WL, Shen SH, Du TT, Li H, He F, Xiao HS, Wang ZG, Liu TX, Lu H, Huang QH, Chen SJ, Chen Z
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133625
Contribution of plasminogen activation towards the pathogenic potential of oral streptococci.
Itzek A, Gillen CM, Fulde M, Friedrichs C, Rodloff AC, Chhatwal GS, Nitsche-Schmitz DP
PLoS One. 2010
PubMed ID: 21072208
Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation.
McCready J, Sims JD, Chan D, Jay DG
BMC Cancer. 2010
PubMed ID: 20553606
Treatment of episodes of hereditary angioedema with C1 inhibitor: serial assessment of observed abnormalities of the plasma bradykinin-forming pathway and fibrinolysis.
Joseph K, Tholanikunnel TE, Kaplan AP
Ann Allergy Asthma Immunol. 2010
PubMed ID: 20143645
Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.
Ryckman KK, Morken NH, White MJ, Velez DR, Menon R, Fortunato SJ, Magnus P, Williams SM, Jacobsson B
PLoS One. 2010
PubMed ID: 20140262
Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a Factor H, FHL-1 and plasminogen binding surface protein.
Luo S, Poltermann S, Kunert A, Rupp S, Zipfel PF
Mol Immunol. 2009
PubMed ID: 19850343
Role of plasminogen activation in neuronal organization and survival.
Ho-Tin-Noé B, Enslen H, Doeuvre L, Corsi JM, Lijnen HR, Anglés-Cano E
Mol Cell Neurosci. 2009
PubMed ID: 19683575
Identification of a new exosite involved in catalytic turnover by the streptokinase-plasmin activator complex during human plasminogen activation.
Aneja R, Datt M, Singh B, Kumar S, Sahni G
J Biol Chem. 2009
PubMed ID: 19801674
Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavage.
Poon IK, Olsson AK, Hulett MD, Parish CR
Biochem J. 2009
PubMed ID: 19712047
Solution structure and functional characterization of human plasminogen kringle 5.
Battistel MD, Grishaev A, An SS, Castellino FJ, Llinás M
Biochemistry. 2009
PubMed ID: 19821587
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation.
Tjwa M, Moura R, Moons L, Plaisance S, De Mol M, Jansen S, Dewerchin M, Verfaillie C, Carmeliet P
J Cell Mol Med. 2009
PubMed ID: 19210287
A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis.
Crane DD, Warner SL, Bosio CM
J Immunol. 2009
PubMed ID: 19752236
Bifidobacterial enolase, a cell surface receptor for human plasminogen involved in the interaction with the host.
Candela M, Biagi E, Centanni M, Turroni S, Vici M, Musiani F, Vitali B, Bergmann S, Hammerschmidt S, Brigidi P
Microbiology. 2009
PubMed ID: 19574304
Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins.
Lee TY, Muschal S, Pravda EA, Folkman J, Abdollahi A, Javaherian K
Blood. 2009
PubMed ID: 19465692
Plasmin plays a role in the in vitro generation of the linear IgA dermatosis antigen LADB97.
Hofmann SC, Voith U, Schönau V, Sorokin L, Bruckner-Tuderman L, Franzke CW
J Invest Dermatol. 2009
PubMed ID: 19158842
Defining the structural basis of human plasminogen binding by streptococcal surface enolase.
Cork AJ, Jergic S, Hammerschmidt S, Kobe B, Pancholi V, Benesch JL, Robinson CV, Dixon NE, Aquilina JA, Walker MJ
J Biol Chem. 2009
PubMed ID: 19363026
Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair.
Shanmukhappa K, Matte U, Degen JL, Bezerra JA
J Biol Chem. 2009
PubMed ID: 19286661
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Tissue plasminogen activator promotes axonal outgrowth on CNS myelin after conditioned injury.
Minor K, Phillips J, Seeds NW
J Neurochem. 2009
PubMed ID: 19220707
Monitoring of functional plasminogen in the blood of patients on fibrinolytics.
Stief TW, Richter A, Maisch B, Renz H
Clin Appl Thromb Hemost. 2009
PubMed ID: 18160581
Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells.
Tjwa M, Sidenius N, Moura R, Jansen S, Theunissen K, Andolfo A, De Mol M, Dewerchin M, Moons L, Blasi F, Verfaillie C, Carmeliet P
J Clin Invest. 2009
PubMed ID: 19273908
The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain.
Zhang C, An J, Strickland DK, Yepes M
Am J Pathol. 2009
PubMed ID: 19147818
Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation.
Sodha NR, Clements RT, Boodhwani M, Xu SH, Laham RJ, Bianchi C, Sellke FW
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19074676
Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity.
Grosskinsky S, Schott M, Brenner C, Cutler SJ, Kraiczy P, Zipfel PF, Simon MM, Wallich R
PLoS One. 2009
PubMed ID: 19308255
A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response.
Hoover-Plow J, Hart E, Gong Y, Shchurin A, Schneeman T
Exp Biol Med (Maywood). 2009
PubMed ID: 18997104
Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism.
Mu W, Long DA, Ouyang X, Agarwal A, Cruz PE, Roncal CA, Nakagawa T, Yu X, Hauswirth WW, Johnson RJ
Am J Physiol Renal Physiol. 2009
PubMed ID: 18971211
Plasmin activates epithelial Na+ channels by cleaving the gamma subunit.
Passero CJ, Mueller GM, Rondon-Berrios H, Tofovic SP, Hughey RP, Kleyman TR
J Biol Chem. 2008
PubMed ID: 18981180
Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen: a novel mechanism for lipoprotein(a)-mediated inhibition of plasminogen activation.
Feric NT, Boffa MB, Johnston SM, Koschinsky ML
J Thromb Haemost. 2008
PubMed ID: 18983515
Plasminogen mediates the atherogenic effects of macrophage-expressed urokinase and accelerates atherosclerosis in apoE-knockout mice.
Kremen M, Krishnan R, Emery I, Hu JH, Slezicki KI, Wu A, Qian K, Du L, Plawman A, Stempien-Otero A, Dichek DA
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18957535
Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain.
An J, Zhang C, Polavarapu R, Zhang X, Zhang X, Yepes M
Blood. 2008
PubMed ID: 18628488
Annexin A2 regulates the levels of plasmin, S100A10 and Fascin in L5178Y cells.
Hou Y, Yang L, Mou M, Hou Y, Zhang A, Pan N, Qiang R, Wei L, Zhang N
Cancer Invest. 2008
PubMed ID: 18608216
Rapid-reaction kinetic characterization of the pathway of streptokinase-plasmin catalytic complex formation.
Verhamme IM, Bock PE
J Biol Chem. 2008
PubMed ID: 18658146
Plasmin-mediated processing of protein tyrosine phosphatase receptor type Z in the mouse brain.
Chow JP, Fujikawa A, Shimizu H, Noda M
Neurosci Lett. 2008
PubMed ID: 18647637
Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.
Picariello G, Ferranti P, Mamone G, Roepstorff P, Addeo F
Proteomics. 2008
PubMed ID: 18780401
Neutrophil apoptosis: selective regulation by different ligands of integrin alphaMbeta2.
Pluskota E, Soloviev DA, Szpak D, Weber C, Plow EF
J Immunol. 2008
PubMed ID: 18714035
Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes.
Okada K, Ueshima S, Kawao N, Okamoto C, Matsuo K, Akao M, Seki T, Ariga T, Tanaka M, Matsuo O
Blood Coagul Fibrinolysis. 2008
PubMed ID: 18685433
Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice.
Gong Y, Hart E, Shchurin A, Hoover-Plow J
J Clin Invest. 2008
PubMed ID: 18677407
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
Wang J, Yuan Y, Zhou Y, Guo L, Zhang L, Kuai X, Deng B, Pan Z, Li D, He F
J Proteome Res. 2008
PubMed ID: 18624398
Plasminogen-induced aggregation of PANC-1 cells requires conversion to plasmin and is inhibited by endogenous plasminogen activator inhibitor-1.
Deshet N, Lupu-Meiri M, Espinoza I, Fili O, Shapira Y, Lupu R, Gershengorn MC, Oron Y
J Cell Physiol. 2008
PubMed ID: 18366077
Plasminogen-dependent proteolytic activity in Bifidobacterium lactis.
Candela M, Miccoli G, Bergmann S, Turroni S, Vitali B, Hammerschmidt S, Brigidi P
Microbiology. 2008
PubMed ID: 18667578
Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen.
Green KA, Almholt K, Ploug M, Rønø B, Castellino FJ, Johnsen M, Bugge TH, Rømer J, Lund LR
J Invest Dermatol. 2008
PubMed ID: 18337830
Staphylokinase reduces plasmin formation by endogenous plasminogen activators.
Jin T, Bokarewa M, Zhu Y, Tarkowski A
Eur J Haematol. 2008
PubMed ID: 18331597
Elevated urinary plasmin activity resistant to alpha2-antiplasmin in acute poststreptococcal glomerulonephritis.
Oda T, Tamura K, Yoshizawa N, Sugisaki T, Matsumoto K, Hattori M, Sawai T, Namikoshi T, Yamada M, Kikuchi Y, Suzuki S, Miura S
Nephrol Dial Transplant. 2008
PubMed ID: 18223261
Plasminogen derivatives encoding kringles 1-4 and kringles 1-5 exert indirect antiangiogenic and direct antitumoral effects in experimental lung cancer.
Schmitz V, Raskopf E, Gonzalez-Carmona MA, Vogt A, Kornek M, Sauerbruch T, Caselmann WH
Cancer Invest. 2008
PubMed ID: 18568768
Plasminogen alleles influence susceptibility to invasive aspergillosis.
Zaas AK, Liao G, Chien JW, Weinberg C, Shore D, Giles SS, Marr KA, Usuka J, Burch LH, Perera L, Perfect JR, Peltz G, Schwartz DA
PLoS Genet. 2008
PubMed ID: 18566672
Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain.
Nogami K, Nishiya K, Saenko EL, Takeyama M, Tanaka I, Yoshioka A, Shima M
Biochim Biophys Acta. 2008
PubMed ID: 18329389
Mutation of human plasminogen kringle 1-5 enhances anti-angiogenic action via increased interaction with integrin alpha(v)beta(3).
Chang PC, Chang YJ, Wu HL, Chang CW, Lin CI, Wang WC, Shi GY
Thromb Haemost. 2008
PubMed ID: 18392331
Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease.
Seth D, Hogg PJ, Gorrell MD, McCaughan GW, Haber PS
J Hepatol. 2008
PubMed ID: 18289715
Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritis.
Guo Y, Li J, Hagström E, Ny T
Arthritis Rheum. 2008
PubMed ID: 18311818
Plasminogen binding by oral streptococci from dental plaque and inflammatory lesions.
Kinnby B, Booth NA, Svensäter G
Microbiology. 2008
PubMed ID: 18310038
Suppressed catalytic efficiency of plasmin in the presence of long-chain fatty acids. Identification of kinetic parameters from continuous enzymatic assay with Monte Carlo simulation.
Tanka-Salamon A, Tenekedjiev K, Machovich R, Kolev K
FEBS J. 2008
PubMed ID: 18279394
Plasminogen potentiates thrombin cytotoxicity and contributes to pathology of intracerebral hemorrhage in rats.
Fujimoto S, Katsuki H, Ohnishi M, Takagi M, Kume T, Akaike A
J Cereb Blood Flow Metab. 2008
PubMed ID: 17940541
Cathepsin V, but not cathepsins L, B and K, may release angiostatin-like fragments from plasminogen.
Puzer L, Barros NM, Paschoalin T, Hirata IY, Tanaka AS, Oliveira MC, Brömme D, Carmona AK
Biol Chem. 2008
PubMed ID: 18163891
Streptococcus pneumoniae choline-binding protein E interaction with plasminogen/plasmin stimulates migration across the extracellular matrix.
Attali C, Frolet C, Durmort C, Offant J, Vernet T, Di Guilmi AM
Infect Immun. 2008
PubMed ID: 18070889
The opportunistic human pathogenic fungus Aspergillus fumigatus evades the host complement system.
Behnsen J, Hartmann A, Schmaler J, Gehrke A, Brakhage AA, Zipfel PF
Infect Immun. 2008
PubMed ID: 18039838
Key role of tissue plasminogen activator in neurovascular coupling.
Park L, Gallo EF, Anrather J, Wang G, Norris EH, Paul J, Strickland S, Iadecola C
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18195371
The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain.
Fu Q, Figuera-Losada M, Ploplis VA, Cnudde S, Geiger JH, Prorok M, Castellino FJ
J Biol Chem. 2008
PubMed ID: 18039665
Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice.
Witting PK, Zeng B, Wong M, McMahon AC, Rayner BS, Sapir AJ, Lowe HC, Freedman SB, Brieger DB
Thromb Res. 2008
PubMed ID: 18420257
Plasminogen activator induction facilitates recovery of respiratory function following spinal cord injury.
Minor KH, Seeds NW
Mol Cell Neurosci. 2008
PubMed ID: 18042398
Protective role of thrombin activatable fibrinolysis inhibitor in obstructive nephropathy-associated tubulointerstitial fibrosis.
Bruno NE, Yano Y, Takei Y, Gabazza EC, Qin L, Nagashima M, Morser J, D'Alessandro-Gabazza CN, Taguchi O, Sumida Y
J Thromb Haemost. 2008
PubMed ID: 17988229
Variation in 24 hemostatic genes and associations with non-fatal myocardial infarction and ischemic stroke.
Smith NL, Bis JC, Biagiotti S, Rice K, Lumley T, Kooperberg C, Wiggins KL, Heckbert SR, Psaty BM
J Thromb Haemost. 2008
PubMed ID: 17927806
Plasminogen activation induced pericellular fibronectin proteolysis promotes fibroblast apoptosis.
Horowitz JC, Rogers DS, Simon RH, Sisson TH, Thannickal VJ
Am J Respir Cell Mol Biol. 2008
PubMed ID: 17656680
The plasminogen fibrinolytic pathway is required for hematopoietic regeneration.
Heissig B, Lund LR, Akiyama H, Ohki M, Morita Y, Rømer J, Nakauchi H, Okumura K, Ogawa H, Werb Z, Danø K, Hattori K
Cell Stem Cell. 2007
PubMed ID: 18371407
Fibrinogen deficiency, but not plasminogen deficiency, increases mortality synergistically in combination with sickle hemoglobin SAD in transgenic mice.
Roszell NJ, Danton MJ, Jiang M, Witte D, Daugherty C, Grimes T, Girdler B, Anderson KP, Franco RS, Degen JL, Joiner CH
Am J Hematol. 2007
PubMed ID: 17722076
A plasma nucleosome releasing factor (NRF) with serine protease activity is instrumental in removal of nucleosomes from secondary necrotic cells.
Zeerleder S, Zwart B, te Velthuis H, Manoe R, Bulder I, Rensink I, Aarden LA
FEBS Lett. 2007
PubMed ID: 17976375
Histone H2B as a functionally important plasminogen receptor on macrophages.
Das R, Burke T, Plow EF
Blood. 2007
PubMed ID: 17690254
Enolase as a plasminogen binding protein in Leishmania mexicana.
Vanegas G, Quiñones W, Carrasco-López C, Concepción JL, Albericio F, Avilán L
Parasitol Res. 2007
PubMed ID: 17653767
Identification of critical residues for plasminogen binding by the alphaX I-domain of the beta2 integrin, alphaXbeta2.
Gang J, Choi J, Lee JH, Nham SU
Mol Cells. 2007
PubMed ID: 17978577
Hydroxyethyl starch enhances fibrinolysis in human plasma by diminishing alpha2-antiplasmin-plasmin interactions.
Nielsen VG
Blood Coagul Fibrinolysis. 2007
PubMed ID: 17890952
Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein mediate cerebral ischemia-induced nuclear factor-kappaB pathway activation.
Zhang X, Polavarapu R, She H, Mao Z, Yepes M
Am J Pathol. 2007
PubMed ID: 17717150
Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro.
Lacroix R, Sabatier F, Mialhe A, Basire A, Pannell R, Borghi H, Robert S, Lamy E, Plawinski L, Camoin-Jau L, Gurewich V, Angles-Cano E, Dignat-George F
Blood. 2007
PubMed ID: 17606760
Plasmin inhibition increases MMP-9 activity and decreases vein wall stiffness during venous thrombosis resolution.
Dewyer NA, Sood V, Lynch EM, Luke CE, Upchurch GR, Wakefield TW, Kunkel S, Henke PK
J Surg Res. 2007
PubMed ID: 17574586
Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease.
Paul J, Strickland S, Melchor JP
J Exp Med. 2007
PubMed ID: 17664291
Plasminogen gene expression is regulated by nerve growth factor.
Gutiérrez-Fernández A, Parmer RJ, Miles LA
J Thromb Haemost. 2007
PubMed ID: 17663741
Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice.
Suzuki Y, Nagai N, Umemura K, Collen D, Lijnen HR
J Thromb Haemost. 2007
PubMed ID: 17596135
Regulation of nonproteolytic active site formation in plasminogen.
Gladysheva IP, Sazonova IY, Houng A, Hedstrom L, Reed GL
Biochemistry. 2007
PubMed ID: 17616171
Association studies between the plasmin genes and late-onset Alzheimer's disease.
Shibata N, Kawarai T, Meng Y, Lee JH, Lee HS, Wakutani Y, Shibata E, Pathan N, Bi A, Sato C, Sorbi S, Bruni AC, Duara R, Mayeux R, Farrer LA, George-Hyslop PS, Rogaeva E
Neurobiol Aging. 2007
PubMed ID: 16828203
Cell surface-bound plasminogen regulates hepatocyte proliferation through a uPA-dependent mechanism.
Okumura N, Seki T, Ariga T
Biosci Biotechnol Biochem. 2007
PubMed ID: 17587687
Interaction between cancer cells and stromal fibroblasts is required for activation of the uPAR-uPA-MMP-2 cascade in pancreatic cancer metastasis.
He Y, Liu XD, Chen ZY, Zhu J, Xiong Y, Li K, Dong JH, Li X
Clin Cancer Res. 2007
PubMed ID: 17545513
Plasmin decreases the BH3-only protein BimEL via the ERK1/2 signaling pathway in hepatocytes.
Kawao N, Okada K, Kawata S, Okamoto C, Tsuritani M, Ueshima S, Matsuo O
Biochim Biophys Acta. 2007
PubMed ID: 17482686
Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells.
Nguyen TM, Subramanian IV, Kelekar A, Ramakrishnan S
Blood. 2007
PubMed ID: 17272502
Plasminogen and angiostatin interact with heat shock proteins.
Dudani AK, Mehic J, Martyres A
Mol Cell Biochem. 2007
PubMed ID: 17206383
Mechanisms of TGF-beta1-induced intimal growth: plasminogen-independent activities of plasminogen activator inhibitor-1 and heterogeneous origin of intimal cells.
Otsuka G, Stempien-Otero A, Frutkin AD, Dichek DA
Circ Res. 2007
PubMed ID: 17431190
Extracellular proteins of Lactobacillus crispatus enhance activation of human plasminogen.
Hurmalainen V, Edelman S, Antikainen J, Baumann M, Lähteenmäki K, Korhonen TK
Microbiology. 2007
PubMed ID: 17379720
Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR.
Passino MA, Adams RA, Sikorski SL, Akassoglou K
Science. 2007
PubMed ID: 17395831
Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals.
Zhang G, Kernan KA, Collins SJ, Cai X, López-Guisa JM, Degen JL, Shvil Y, Eddy AA
J Am Soc Nephrol. 2007
PubMed ID: 17267741
Functional corpora lutea are formed in matrix metalloproteinase inhibitor-treated plasminogen-deficient mice.
Wahlberg P, Bodén I, Paulsson J, Lund LR, Liu K, Ny T
Endocrinology. 2007
PubMed ID: 17122079
TagSNP evaluation for the association of 42 inflammation loci and vascular disease: evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects.
Carlson CS, Heagerty PJ, Nord AS, Pritchard DK, Ranchalis J, Boguch JM, Duan H, Hatsukami TS, Schwartz SM, Rieder MJ, Nickerson DA, Jarvik GP
Hum Genet. 2007
PubMed ID: 17115186
Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice.
Sheehan JJ, Zhou C, Gravanis I, Rogove AD, Wu YP, Bogenhagen DF, Tsirka SE
J Neurosci. 2007
PubMed ID: 17301181
Induction of alpha2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion.
Hayashido Y, Hamana T, Ishida Y, Shintani T, Koizumi K, Okamoto T
Oncol Rep. 2007
PubMed ID: 17203182
Reduction of experimental diabetic vascular leakage by delivery of angiostatin with a recombinant adeno-associated virus vector.
Shyong MP, Lee FL, Kuo PC, Wu AC, Cheng HC, Chen SL, Tung TH, Tsao YP
Mol Vis. 2007
PubMed ID: 17293777
Plasminogen binds to plasmin-modulated factor Xa by Ca(2+) - and C-terminal lysine-dependent and -independent interactions.
Grundy JE, Hancock MA, Meixner SC, MacKenzie RC, Koschinsky ML, Pryzdial EL
Thromb Haemost. 2007
PubMed ID: 17200769
Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice.
Kessler SP, Senanayake P, Gaughan C, Sen GC
FASEB J. 2007
PubMed ID: 17135368
Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2.
Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH
Mol Cell Biol. 2006
PubMed ID: 16966370
Spontaneous development of otitis media in plasminogen-deficient mice.
Eriksson PO, Li J, Ny T, Hellström S
Int J Med Microbiol. 2006
PubMed ID: 16956791
Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation.
Green KA, Nielsen BS, Castellino FJ, Rømer J, Lund LR
Dev Biol. 2006
PubMed ID: 16949567
Identification of candidate maternal-effect genes through comparison of multiple microarray data sets.
Mager J, Schultz RM, Brunk BP, Bartolomei MS
Mamm Genome. 2006
PubMed ID: 16964442
Trigger for group A streptococcal M1T1 invasive disease.
Cole JN, McArthur JD, McKay FC, Sanderson-Smith ML, Cork AJ, Ranson M, Rohde M, Itzek A, Sun H, Ginsburg D, Kotb M, Nizet V, Chhatwal GS, Walker MJ
FASEB J. 2006
PubMed ID: 16790522
Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice.
Renckens R, Roelofs JJ, Florquin S, de Vos AF, Pater JM, Lijnen HR, Carmeliet P, van 't Veer C, van der Poll T
J Immunol. 2006
PubMed ID: 16818777
Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.
Lund LR, Green KA, Stoop AA, Ploug M, Almholt K, Lilla J, Nielsen BS, Christensen IJ, Craik CS, Werb Z, Danø K, Rømer J
EMBO J. 2006
PubMed ID: 16763560
Mechanisms of cardiac fibrosis induced by urokinase plasminogen activator.
Stempien-Otero A, Plawman A, Meznarich J, Dyamenahalli T, Otsuka G, Dichek DA
J Biol Chem. 2006
PubMed ID: 16554301
Plasminogen inhibits TNFalpha-induced apoptosis in monocytes.
Mitchell JW, Baik N, Castellino FJ, Miles LA
Blood. 2006
PubMed ID: 16478887
Insulin-like growth factor-binding protein-5 activates plasminogen by interaction with tissue plasminogen activator, independently of its ability to bind to plasminogen activator inhibitor-1, insulin-like growth factor-I, or heparin.
Sorrell AM, Shand JH, Tonner E, Gamberoni M, Accorsi PA, Beattie J, Allan GJ, Flint DJ
J Biol Chem. 2006
PubMed ID: 16505491
Unaltered prion protein cleavage in plasminogen-deficient mice.
Barnewitz K, Maringer M, Mitteregger G, Giese A, Bertsch U, Kretzschmar HA
Neuroreport. 2006
PubMed ID: 16543819
Anti-angiogenesis mediated by angiostatin K1-3, K1-4 and K1-4.5. Involvement of p53, FasL, AKT and mRNA deregulation.
Chen YH, Wu HL, Li C, Huang YH, Chiang CW, Wu MP, Wu LW
Thromb Haemost. 2006
PubMed ID: 16601838
Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity.
Yang X, Cheng R, Li C, Cai W, Ma JX, Liu Q, Yang Z, Song Z, Liu Z, Gao G
Cancer Biol Ther. 2006
PubMed ID: 16481742
The role of beta2-glycoprotein I (beta2GPI) in the activation of plasminogen.
López-Lira F, Rosales-León L, Martínez VM, Ruiz Ordaz BH
Biochim Biophys Acta. 2006
PubMed ID: 16480936
Potentiation of TLR4 signalling by plasmin activity.
Ward JR, Dower SK, Whyte MK, Buttle DJ, Sabroe I
Biochem Biophys Res Commun. 2006
PubMed ID: 16413499
Divergence in the plasminogen-binding group a streptococcal M protein family: functional conservation of binding site and potential role for immune selection of variants.
Sanderson-Smith M, Batzloff M, Sriprakash KS, Dowton M, Ranson M, Walker MJ
J Biol Chem. 2006
PubMed ID: 16319056
Genetic background determines response to hemostasis and thrombosis.
Hoover-Plow J, Shchurin A, Hart E, Sha J, Hill AE, Singer JB, Nadeau JH
BMC Blood Disord. 2006
PubMed ID: 17022820
Specific conformational changes of plasminogen induced by chloride ions, 6-aminohexanoic acid and benzamidine, but not the overall openness of plasminogen regulate, production of biologically active angiostatins.
Warejcka DJ, Twining SS
Biochem J. 2005
PubMed ID: 16097950
Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus.
Pawlak R, Rao BS, Melchor JP, Chattarji S, McEwen B, Strickland S
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16330749
Protein S attenuates the invasive potential of THP-1 cells by interfering with plasminogen binding on cell surface via a protein C-independent mechanism.
Hryszko T, Suzuki Y, Mogami H, Urano T
FEBS Lett. 2005
PubMed ID: 16229836
The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice.
Cheng Q, Zhao Y, Lawson WE, Polosukhin VV, Johnson JE, Blackwell TS, Gailani D
Blood. 2005
PubMed ID: 15985536
Plasmin- and thrombin-accelerated shedding of syndecan-4 ectodomain generates cleavage sites at Lys(114)-Arg(115) and Lys(129)-Val(130) bonds.
Schmidt A, Echtermeyer F, Alozie A, Brands K, Buddecke E
J Biol Chem. 2005
PubMed ID: 16087677
Angiomotin regulates endothelial cell-cell junctions and cell motility.
Bratt A, Birot O, Sinha I, Veitonmäki N, Aase K, Ernkvist M, Holmgren L
J Biol Chem. 2005
PubMed ID: 16043488
Long-range DNase I hypersensitivity mapping reveals the imprinted Igf2r and Air promoters share cis-regulatory elements.
Pauler FM, Stricker SH, Warczok KE, Barlow DP
Genome Res. 2005
PubMed ID: 16204191
Apo(a) promotes thrombosis in a vascular injury model by a mechanism independent of plasminogen.
Sha J, McCullough B, Hart E, Nassir F, Davidson NO, Hoover-Plow J
J Thromb Haemost. 2005
PubMed ID: 16150044
MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells.
Filippov S, Koenig GC, Chun TH, Hotary KB, Ota I, Bugge TH, Roberts JD, Fay WP, Birkedal-Hansen H, Holmbeck K, Sabeh F, Allen ED, Weiss SJ
J Exp Med. 2005
PubMed ID: 16147977
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Role of plasminogen in propagation of scrapie.
Salmona M, Capobianco R, Colombo L, De Luigi A, Rossi G, Mangieri M, Giaccone G, Quaglio E, Chiesa R, Donati MB, Tagliavini F, Forloni G
J Virol. 2005
PubMed ID: 16103174
Contrasting roles of plasminogen deficiency in different rheumatoid arthritis models.
Li J, Guo Y, Holmdahl R, Ny T
Arthritis Rheum. 2005
PubMed ID: 16052596
Association of plasminogen with dipeptidyl peptidase IV and Na+/H+ exchanger isoform NHE3 regulates invasion of human 1-LN prostate tumor cells.
Gonzalez-Gronow M, Misra UK, Gawdi G, Pizzo SV
J Biol Chem. 2005
PubMed ID: 15911629
Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice.
Shanmukhappa K, Mourya R, Sabla GE, Degen JL, Bezerra JA
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16006527
Bacillolysin MA, a novel bacterial metalloproteinase that produces angiostatin-like fragments from plasminogen and activates protease zymogens in the coagulation and fibrinolysis systems.
Narasaki R, Kuribayashi H, Shimizu K, Imamura D, Sato T, Hasumi K
J Biol Chem. 2005
PubMed ID: 15677446
Synergy between a plasminogen cascade and MMP-9 in autoimmune disease.
Liu Z, Li N, Diaz LA, Shipley M, Senior RM, Werb Z
J Clin Invest. 2005
PubMed ID: 15841177
Plasminogen/plasmin regulates c-fos and egr-1 expression via the MEK/ERK pathway.
De Sousa LP, Brasil BS, Silva BM, Freitas MH, Nogueira SV, Ferreira PC, Kroon EG, Bonjardim CA
Biochem Biophys Res Commun. 2005
PubMed ID: 15721299
Interaction of insulin-like growth factor II (IGF-II) with multiple plasma proteins: high affinity binding of plasminogen to IGF-II and IGF-binding protein-3.
Oesterreicher S, Blum WF, Schmidt B, Braulke T, Kübler B
J Biol Chem. 2005
PubMed ID: 15642732
The plasminogen activator/plasmin system is essential for development of the joint inflammatory phase of collagen type II-induced arthritis.
Li J, Ny A, Leonardsson G, Nandakumar KS, Holmdahl R, Ny T
Am J Pathol. 2005
PubMed ID: 15743790
Beta-amyloid (Abeta) causes detachment of N1E-115 neuroblastoma cells by acting as a scaffold for cell-associated plasminogen activation.
Kranenburg O, Bouma B, Gent YY, Aarsman CJ, Kayed R, Posthuma G, Schiks B, Voest EE, Gebbink MF
Mol Cell Neurosci. 2005
PubMed ID: 15737740
Binding of recombinant PrPc to human plasminogen: kinetic and thermodynamic study using a resonant mirror biosensor.
Cuccioloni M, Amici M, Eleuteri AM, Biagetti M, Barocci S, Angeletti M
Proteins. 2005
PubMed ID: 15609351
Angiostatin and plasminogen share binding to endothelial cell surface actin.
Dudani AK, Ben-Tchavtchavadze M, Porter S, Tackaberry E
Biochem Cell Biol. 2005
PubMed ID: 15746964
Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors.
Pawlak R, Melchor JP, Matys T, Skrzypiec AE, Strickland S
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15630096
Searching QTL by gene expression: analysis of diabesity.
Brown AC, Olver WI, Donnelly CJ, May ME, Naggert JK, Shaffer DJ, Roopenian DC
BMC Genet. 2005
PubMed ID: 15760467
MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix.
Chun TH, Sabeh F, Ota I, Murphy H, McDonagh KT, Holmbeck K, Birkedal-Hansen H, Allen ED, Weiss SJ
J Cell Biol. 2004
PubMed ID: 15545316
Tissue plasminogen activator promotes the effects of corticotropin-releasing factor on the amygdala and anxiety-like behavior.
Matys T, Pawlak R, Matys E, Pavlides C, McEwen BS, Strickland S
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15522965
Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen.
Ge J, Catt DM, Gregory RL
Infect Immun. 2004
PubMed ID: 15501816
Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity.
Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K, Zhen S, Teng KK, Yung WH, Hempstead BL, Lu B
Science. 2004
PubMed ID: 15486301
Effects of histidine-proline-rich glycoprotein on plasminogen activation in solution and on surfaces.
Borza DB, Shipulina NV, Morgan WT
Blood Coagul Fibrinolysis. 2004
PubMed ID: 15613921
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
A central role for plasminogen in the inflammatory response to biomaterials.
Busuttil SJ, Ploplis VA, Castellino FJ, Tang L, Eaton JW, Plow EF
J Thromb Haemost. 2004
PubMed ID: 15456492
Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice.
Tucker HM, Simpson J, Kihiko-Ehmann M, Younkin LH, McGillis JP, Younkin SG, Degen JL, Estus S
Neurosci Lett. 2004
PubMed ID: 15364412
Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein.
Jones AL, Hulett MD, Altin JG, Hogg P, Parish CR
J Biol Chem. 2004
PubMed ID: 15220341
Mycoplasma fermentans binds to and invades HeLa cells: involvement of plasminogen and urokinase.
Yavlovich A, Katzenell A, Tarshis M, Higazi AA, Rottem S
Infect Immun. 2004
PubMed ID: 15321992
Plasminogen is a critical host pathogenicity factor for group A streptococcal infection.
Sun H, Ringdahl U, Homeister JW, Fay WP, Engleberg NC, Yang AY, Rozek LS, Wang X, Sjöbring U, Ginsburg D
Science. 2004
PubMed ID: 15333838
Resolution of conformational activation in the kinetic mechanism of plasminogen activation by streptokinase.
Boxrud PD, Verhamme IM, Bock PE
J Biol Chem. 2004
PubMed ID: 15215240
Characterization of Lys-698-to-Met substitution in human plasminogen catalytic domain.
Terzyan S, Wakeham N, Zhai P, Rodgers K, Zhang XC
Proteins. 2004
PubMed ID: 15211511
The PDGF family: four gene products form five dimeric isoforms.
Fredriksson L, Li H, Eriksson U
Cytokine Growth Factor Rev. 2004
PubMed ID: 15207811
Characterization of plasminogen as an adhesive ligand for integrins alphaMbeta2 (Mac-1) and alpha5beta1 (VLA-5).
Lishko VK, Novokhatny VV, Yakubenko VP, Skomorovska-Prokvolit HV, Ugarova TP
Blood. 2004
PubMed ID: 15090462
Characterization of a complex formed between human plasminogen and recombinant sheep prion: pressure and thermal sensitivity of complex formation.
Kornblatt JA, Marchal S, Rezaei H, Balny C
Cell Mol Biol (Noisy-le-grand). 2004
PubMed ID: 15529749
Plasminogen mediates the pathological effects of urokinase-type plasminogen activator overexpression.
Bolon I, Zhou HM, Charron Y, Wohlwend A, Vassalli JD
Am J Pathol. 2004
PubMed ID: 15161662
Nicked beta2-glycoprotein I: a marker of cerebral infarct and a novel role in the negative feedback pathway of extrinsic fibrinolysis.
Yasuda S, Atsumi T, Ieko M, Matsuura E, Kobayashi K, Inagaki J, Kato H, Tanaka H, Yamakado M, Akino M, Saitou H, Amasaki Y, Jodo S, Amengual O, Koike T
Blood. 2004
PubMed ID: 14726399
Plasminogen regulates pro-opiomelanocortin processing.
Wang N, Zhang L, Miles L, Hoover-Plow J
J Thromb Haemost. 2004
PubMed ID: 15099286
Integrin alphaMbeta2 orchestrates and accelerates plasminogen activation and fibrinolysis by neutrophils.
Pluskota E, Soloviev DA, Bdeir K, Cines DB, Plow EF
J Biol Chem. 2004
PubMed ID: 14769799
Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia.
Brown TA, Yang TM, Zaitsevskaia T, Xia Y, Dunn CA, Sigle RO, Knudsen B, Carter WG
J Biol Chem. 2004
PubMed ID: 14739293
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Protease nexin-1 inhibits plasminogen activation-induced apoptosis of adherent cells.
Rossignol P, Ho-Tin-Noé B, Vranckx R, Bouton MC, Meilhac O, Lijnen HR, Guillin MC, Michel JB, Anglés-Cano E
J Biol Chem. 2004
PubMed ID: 14699093
The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release.
Nagai T, Yamada K, Yoshimura M, Ishikawa K, Miyamoto Y, Hashimoto K, Noda Y, Nitta A, Nabeshima T
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14988509
Inhibition of plasmin activity by tranexamic acid does not influence inflammatory pathways during human endotoxemia.
Renckens R, Weijer S, de Vos AF, Pater JM, Meijers JC, Hack CE, Levi M, van der Poll T
Arterioscler Thromb Vasc Biol. 2004
PubMed ID: 14739127
Nonlysine-analog plasminogen modulators promote autoproteolytic generation of plasmin(ogen) fragments with angiostatin-like activity.
Ohyama S, Harada T, Chikanishi T, Miura Y, Hasumi K
Eur J Biochem. 2004
PubMed ID: 14764098
Elevated levels of angiostatin in effusions from patients with malignant disease.
Rotenberg RG, Rozas NS, Guerri L, Cher ML, Gamboni M, Lema N, Bonfil RD
Oncol Rep. 2004
PubMed ID: 14719094
The effects of the plasminogen pathway on scar tissue formation.
Samara GJ, Schaffner AD, Eisenstat J, Nguyen HL
Laryngoscope. 2004
PubMed ID: 14709993
Plasminogen-induced IL-1beta and TNF-alpha production in microglia is regulated by reactive oxygen species.
Min KJ, Jou I, Joe E
Biochem Biophys Res Commun. 2003
PubMed ID: 14651966
A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes.
Heinemann FS, Korza G, Ozols J
J Biol Chem. 2003
PubMed ID: 12928439
The DNA sequence and analysis of human chromosome 6.
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
Nature. 2003
PubMed ID: 14574404
A functional overlap of plasminogen and MMPs regulates vascularization during placental development.
Solberg H, Rinkenberger J, Danø K, Werb Z, Lund LR
Development. 2003
PubMed ID: 12900459
Alpha2-antiplasmin plays a significant role in acute pulmonary embolism.
Matsuno H, Okada K, Ueshima S, Matsuo O, Kozawa O
J Thromb Haemost. 2003
PubMed ID: 12911586
The role of plasminogen in angiogenesis in vivo.
Oh CW, Hoover-Plow J, Plow EF
J Thromb Haemost. 2003
PubMed ID: 12911578
The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection.
Sato J, Schorey J, Ploplis VA, Haalboom E, Krahule L, Castellino FJ
Am J Pathol. 2003
PubMed ID: 12875972
Plasminogen activator inhibitor type-1 deficiency does not influence the outcome of murine pneumococcal pneumonia.
Rijneveld AW, Florquin S, Bresser P, Levi M, De Waard V, Lijnen R, Van Der Zee JS, Speelman P, Carmeliet P, Van Der Poll T
Blood. 2003
PubMed ID: 12702502
The voltage-dependent anion channel is a receptor for plasminogen kringle 5 on human endothelial cells.
Gonzalez-Gronow M, Kalfa T, Johnson CE, Gawdi G, Pizzo SV
J Biol Chem. 2003
PubMed ID: 12736244
Contraceptive pills induce an improvement in congenital hypoplasminogenemia in two unrelated patients with ligneous conjunctivitis.
Teresa Sartori M, Saggiorato G, Pellati D, Casonato A, Spiezia L, Pontara E, Gavasso S, Girolami A
Thromb Haemost. 2003
PubMed ID: 12876630
The hippocampal laminin matrix is dynamic and critical for neuronal survival.
Chen ZL, Indyk JA, Strickland S
Mol Biol Cell. 2003
PubMed ID: 12857855
Inhibition of plasminogen activation by lipoprotein(a): critical domains in apolipoprotein(a) and mechanism of inhibition on fibrin and degraded fibrin surfaces.
Hancock MA, Boffa MB, Marcovina SM, Nesheim ME, Koschinsky ML
J Biol Chem. 2003
PubMed ID: 12697748
Endogenous plasmin converts Glu-plasminogen to Lys-plasminogen on the monocytoid cell surface.
Zhang L, Gong Y, Grella DK, Castellino FJ, Miles LA
J Thromb Haemost. 2003
PubMed ID: 12871329
A fast-acting, modular-structured staphylokinase fusion with Kringle-1 from human plasminogen as the fibrin-targeting domain offers improved clot lysis efficacy.
Wu SC, Castellino FJ, Wong SL
J Biol Chem. 2003
PubMed ID: 12646571
Plasminogen binding and cancer: promises and pitfalls.
Ranson M, Andronicos NM
Front Biosci. 2003
PubMed ID: 12700073
Detection of an Ala601Thr mutation of plasminogen gene in 3 out of 36 Korean patients with deep vein thrombosis.
Song KS, Lee SM, Choi JR
J Korean Med Sci. 2003
PubMed ID: 12692411
Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization.
Rakic JM, Lambert V, Munaut C, Bajou K, Peyrollier K, Alvarez-Gonzalez ML, Carmeliet P, Foidart JM, Noël A
Invest Ophthalmol Vis Sci. 2003
PubMed ID: 12657615
Selective tryptic cleavage at the tethered ligand site of the amino terminal domain of proteinase-activated receptor-2 in intact cells.
Al-Ani B, Hollenberg MD
J Pharmacol Exp Ther. 2003
PubMed ID: 12604689
Plasminogen directs the pleiotropic effects of uPA in liver injury and repair.
Currier AR, Sabla G, Locaputo S, Melin-Aldana H, Degen JL, Bezerra JA
Am J Physiol Gastrointest Liver Physiol. 2003
PubMed ID: 12431907
Angiostatin selectively inhibits signaling by hepatocyte growth factor in endothelial and smooth muscle cells.
Wajih N, Sane DC
Blood. 2003
PubMed ID: 12406896
Cellular density regulation of plasminogen gene expression in mouse hepatocytes.
Akao M, Ueshima S, Okada K, Fukao H, Seki T, Ariga T, Matsuo O
Life Sci. 2003
PubMed ID: 12559391
Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior.
Pawlak R, Magarinos AM, Melchor J, McEwen B, Strickland S
Nat Neurosci. 2003
PubMed ID: 12524546
The role of the fibrinolytic system in corneal angiogenesis.
Vogten JM, Reijerkerk A, Meijers JC, Voest EE, Borel Rinkes IH, Gebbink MF
Angiogenesis. 2003
PubMed ID: 15166500
Computer model of the interaction of human TFPI-2 Kunitz-type serine protease inhibitor with human plasmin.
Hubé F, Reverdiau P, Iochmann S, Gruel Y
Thromb Res. 2003
PubMed ID: 14678821
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro.
Barker-Carlson K, Lawrence DA, Schwartz BS
J Biol Chem. 2002
PubMed ID: 12228252
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity.
Netzel-Arnett S, Mitola DJ, Yamada SS, Chrysovergis K, Holmbeck K, Birkedal-Hansen H, Bugge TH
J Biol Chem. 2002
PubMed ID: 12192005
Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice.
Zeng B, Bruce D, Kril J, Ploplis V, Freedman B, Brieger D
Thromb Haemost. 2002
PubMed ID: 12428098
In vivo regulation of plasminogen function by plasma carboxypeptidase B.
Swaisgood CM, Schmitt D, Eaton D, Plow EF
J Clin Invest. 2002
PubMed ID: 12417566
Activation of human meprin-alpha in a cell culture model of colorectal cancer is triggered by the plasminogen-activating system.
Rösmann S, Hahn D, Lottaz D, Kruse MN, Stöcker W, Sterchi EE
J Biol Chem. 2002
PubMed ID: 12189145
Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression.
Bannach FG, Gutierrez A, Fowler BJ, Bugge TH, Degen JL, Parmer RJ, Miles LA
J Biol Chem. 2002
PubMed ID: 12149246
The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and janus kinase (JAK)/STAT signaling pathways.
Burysek L, Syrovets T, Simmet T
J Biol Chem. 2002
PubMed ID: 12093796
Structural elements that govern the substrate specificity of the clot-dissolving enzyme plasmin.
Turner RB, Liu L, Sazonova IY, Reed GL
J Biol Chem. 2002
PubMed ID: 12080056
Effects of deletion of streptokinase residues 48-59 on plasminogen activation.
Wakeham N, Terzyan S, Zhai P, Loy JA, Tang J, Zhang XC
Protein Eng. 2002
PubMed ID: 12456874
Growth of human squamous cell carcinoma xenografts in mice is inhibited by local angiostatin gene therapy.
Matsumoto G, Sasakuri K, Tsukinoki K, Ohmi Y, Lee U, Shindo J
Oral Oncol. 2002
PubMed ID: 12167431
Plasminogen mRNA induction in the mouse brain after kainate excitation: codistribution with plasminogen activator inhibitor-2 (PAI-2) mRNA.
Sharon R, Abramovitz R, Miskin R
Brain Res Mol Brain Res. 2002
PubMed ID: 12225871
Chimerism reveals a role for the streptokinase Beta -domain in nonproteolytic active site formation, substrate, and inhibitor interactions.
Gladysheva IP, Sazonova IY, Chowdhry SA, Liu L, Turner RB, Reed GL
J Biol Chem. 2002
PubMed ID: 12016220
Tissue factor is the receptor for plasminogen type 1 on 1-LN human prostate cancer cells.
Gonzalez-Gronow M, Gawdi G, Pizzo SV
Blood. 2002
PubMed ID: 12036889
In vivo plasminogen deficiency reduces fat accumulation.
Hoover-Plow J, Ellis J, Yuen L
Thromb Haemost. 2002
PubMed ID: 12083480
Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent.
Yepes M, Sandkvist M, Coleman TA, Moore E, Wu JY, Mitola D, Bugge TH, Lawrence DA
J Clin Invest. 2002
PubMed ID: 12070304
The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin.
Abad MC, Arni RK, Grella DK, Castellino FJ, Tulinsky A, Geiger JH
J Mol Biol. 2002
PubMed ID: 12054798
The p11 subunit of annexin II heterotetramer is regulated by basic carboxypeptidase.
Fogg DK, Bridges DE, Cheung KK, Kassam G, Filipenko NR, Choi KS, Fitzpatrick SL, Nesheim M, Waisman DM
Biochemistry. 2002
PubMed ID: 11939791
Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo.
Suelves M, López-Alemany R, Lluís F, Aniorte G, Serrano E, Parra M, Carmeliet P, Muñoz-Cánoves P
Blood. 2002
PubMed ID: 11929773
Plasminogen has a broad extrahepatic distribution.
Zhang L, Seiffert D, Fowler BJ, Jenkins GR, Thinnes TC, Loskutoff DJ, Parmer RJ, Miles LA
Thromb Haemost. 2002
PubMed ID: 11916082
The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent.
Devy L, Blacher S, Grignet-Debrus C, Bajou K, Masson V, Gerard RD, Gils A, Carmeliet G, Carmeliet P, Declerck PJ, Nöel A, Foidart JM
FASEB J. 2002
PubMed ID: 11818362
Apolipoprotein(a): structure-function relationship at the lysine-binding site and plasminogen activator cleavage site.
Anglés-Cano E, Rojas G
Biol Chem. 2002
PubMed ID: 11928826
The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures.
Nezi L, Greco D, Nitsch L, Garbi C
Biol Chem. 2002
PubMed ID: 11928811
Plasmin generation plays different roles in the formation and removal of arterial and venous thrombus in mice.
Matsuno H, Kozawa O, Okada K, Ueshima S, Matsuo O, Uematsu T
Thromb Haemost. 2002
PubMed ID: 11848464
Plasminogen deficiency leads to impaired lobular reorganization and matrix accumulation after chronic liver injury.
Pohl JF, Melin-Aldana H, Sabla G, Degen JL, Bezerra JA
Am J Pathol. 2001
PubMed ID: 11733368
Regulation of cell survival by secreted proneurotrophins.
Lee R, Kermani P, Teng KK, Hempstead BL
Science. 2001
PubMed ID: 11729324
Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis.
Brodsky S, Chen J, Lee A, Akassoglou K, Norman J, Goligorsky MS
Am J Physiol Heart Circ Physiol. 2001
PubMed ID: 11557572
Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes.
Zwart R, Sleutels F, Wutz A, Schinkel AH, Barlow DP
Genes Dev. 2001
PubMed ID: 11562346
Genetic analysis of the organic cation transporter genes Orct2/Slc22a2 and Orct3/Slc22a3 reduces the critical region for the t haplotype mutant t(w73) to 200 kb.
Zwart R, Verhaagh S, de Jong J, Lyon M, Barlow DP
Mamm Genome. 2001
PubMed ID: 11641723
Delayed invasion of the kidney and brain by Borrelia crocidurae in plasminogen-deficient mice.
Nordstrand A, Shamaei-Tousi A, Ny A, Bergström S
Infect Immun. 2001
PubMed ID: 11500461
Proteolytic cleavage of chromogranin A (CgA) by plasmin. Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release.
Jiang Q, Taupenot L, Mahata SK, Mahata M, O'Connor DT, Miles LA, Parmer RJ
J Biol Chem. 2001
PubMed ID: 11342539
Plasminogen binds to disease-associated prion protein of multiple species.
Maissen M, Roeckl C, Glatzel M, Goldmann W, Aguzzi A
Lancet. 2001
PubMed ID: 11438139
Mice lacking tPA, uPA, or plasminogen genes showed delayed functional recovery after sciatic nerve crush.
Siconolfi LB, Seeds NW
J Neurosci. 2001
PubMed ID: 11404420
Binding of plasminogen and tissue plasminogen activator to plasmin-modulated factor X and factor Xa.
Grundy JE, Lavigne N, Hirama T, MacKenzie CR, Pryzdial EL
Biochemistry. 2001
PubMed ID: 11371191
Structure and binding determinants of the recombinant kringle-2 domain of human plasminogen to an internal peptide from a group A Streptococcal surface protein.
Rios-Steiner JL, Schenone M, Mochalkin I, Tulinsky A, Castellino FJ
J Mol Biol. 2001
PubMed ID: 11350170
Selective behaviors altered in plasminogen-deficient mice are reconstituted with intracerebroventricular injection of plasminogen.
Hoover-Plow J, Skomorovska-Prokvolit O, Welsh S
Brain Res. 2001
PubMed ID: 11306011
Deficiency of urokinase-type plasminogen activator-mediated plasmin generation impairs vascular remodeling during hypoxia-induced pulmonary hypertension in mice.
Levi M, Moons L, Bouché A, Shapiro SD, Collen D, Carmeliet P
Circulation. 2001
PubMed ID: 11306532
Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation.
Troyanovsky B, Levchenko T, Månsson G, Matvijenko O, Holmgren L
J Cell Biol. 2001
PubMed ID: 11257124
A truncated plasminogen activator inhibitor-1 protein induces and inhibits angiostatin (kringles 1-3), a plasminogen cleavage product.
Mulligan-Kehoe MJ, Wagner R, Wieland C, Powell R
J Biol Chem. 2001
PubMed ID: 11113116
The sequence of the human genome.
Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigó R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X
Science. 2001
PubMed ID: 11181995
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Purification, cloning, and characterization of a profibrinolytic plasminogen-binding protein, TIP49a.
Hawley SB, Tamura T, Miles LA
J Biol Chem. 2001
PubMed ID: 11027681
Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains.
Ledesma MD, Da Silva JS, Crassaerts K, Delacourte A, De Strooper B, Dotti CG
EMBO Rep. 2000
PubMed ID: 11263499
Surface expression of a glycolytic enzyme, alpha-enolase, recognized by autoantibodies in connective tissue disorders.
Moscato S, Pratesi F, Sabbatini A, Chimenti D, Scavuzzo M, Passatino R, Bombardieri S, Giallongo A, Migliorini P
Eur J Immunol. 2000
PubMed ID: 11169399
Early embryonic expression of murine coagulation system components.
Ong K, Horsfall W, Conway EM, Schuh AC
Thromb Haemost. 2000
PubMed ID: 11154109
Mutational analysis of affinity and selectivity of kringle-tetranectin interaction. Grafting novel kringle affinity ontp the trtranectin lectin scaffold.
Graversen JH, Jacobsen C, Sigurskjold BW, Lorentsen RH, Moestrup SK, Thogersen HC, Etzerodt M
J Biol Chem. 2000
PubMed ID: 10964919
Binding of disease-associated prion protein to plasminogen.
Fischer MB, Roeckl C, Parizek P, Schwarz HP, Aguzzi A
Nature. 2000
PubMed ID: 11100730
Spatial regulation and activity modulation of plasmin by high affinity binding to the G domain of the alpha 3 subunit of laminin-5.
Goldfinger LE, Jiang L, Hopkinson SB, Stack MS, Jones JC
J Biol Chem. 2000
PubMed ID: 10956663
Effects of microenvironmental extracellular pH and extracellular matrix proteins on angiostatin's activity and on intracellular pH.
Wahl ML, Grant DS
Gen Pharmacol. 2000
PubMed ID: 11888684
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Lactational competence and involution of the mouse mammary gland require plasminogen.
Lund LR, Bjørn SF, Sternlicht MD, Nielsen BS, Solberg H, Usher PA, Osterby R, Christensen IJ, Stephens RW, Bugge TH, Danø K, Werb Z
Development. 2000
PubMed ID: 11003846
Plasminogen and tissue plasminogen activator interact with antithrombin III.
Dudani AK
Thromb Res. 2000
PubMed ID: 10974350
Binding of the NG2 proteoglycan to kringle domains modulates the functional properties of angiostatin and plasmin(ogen).
Goretzki L, Lombardo CR, Stallcup WB
J Biol Chem. 2000
PubMed ID: 10889192
Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry.
Loew D, Perrault C, Morales M, Moog S, Ravanat C, Schuhler S, Arcone R, Pietropaolo C, Cazenave JP, van Dorsselaer A, Lanza F
Biochemistry. 2000
PubMed ID: 10978167
Plasminogen is a critical determinant of vascular remodeling in mice.
Drew AF, Tucker HL, Kombrinck KW, Simon DI, Bugge TH, Degen JL
Circ Res. 2000
PubMed ID: 10903997
Plasminogen binding properties of macrophage inflammatory protein (MIP)-2alpha.
Arza B, Félez J, Fábregas P, Laroche Y, Collen D, Lijnen HR
Thromb Haemost. 2000
PubMed ID: 10928473
The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system.
Swaisgood CM, French EL, Noga C, Simon RH, Ploplis VA
Am J Pathol. 2000
PubMed ID: 10880388
Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction.
Creemers E, Cleutjens J, Smits J, Heymans S, Moons L, Collen D, Daemen M, Carmeliet P
Am J Pathol. 2000
PubMed ID: 10854210
Nonfibrinolytic functions of plasminogen.
Ploplis VA, Castellino FJ
Methods. 2000
PubMed ID: 10816371
Disruption of interkringle disulfide bond of plasminogen kringle 1-3 changes the lysine binding capability of kringle 2, but not its antiangiogenic activity.
Lee H, Kim HK, Lee JH, You WK, Chung SI, Chang SI, Park MH, Hong YK, Joe YA
Arch Biochem Biophys. 2000
PubMed ID: 10700393
Human plasminogen catalytic domain undergoes an unusual conformational change upon activation.
Wang X, Terzyan S, Tang J, Loy JA, Lin X, Zhang XC
J Mol Biol. 2000
PubMed ID: 10656799
Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice.
List K, Jensen ON, Bugge TH, Lund LR, Ploug M, Danø K, Behrendt N
Biochemistry. 2000
PubMed ID: 10642175
Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor.
Mott JD, Thomas CL, Rosenbach MT, Takahara K, Greenspan DS, Banda MJ
J Biol Chem. 2000
PubMed ID: 10625689
Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice.
Drew AF, Schiman HL, Kombrinck KW, Bugge TH, Degen JL, Kaufman AH
Invest Ophthalmol Vis Sci. 2000
PubMed ID: 10634603
Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen.
Heidtmann HH, Nettelbeck DM, Mingels A, Jäger R, Welker HG, Kontermann RE
Br J Cancer. 1999
PubMed ID: 10604721
Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processes.
Chen ZL, Indyk JA, Bugge TH, Kombrinck KW, Degen JL, Strickland S
J Neurosci. 1999
PubMed ID: 10559390
Ovulation in plasminogen-deficient mice.
Ny A, Leonardsson G, Hägglund AC, Hägglöf P, Ploplis VA, Carmeliet P, Ny T
Endocrinology. 1999
PubMed ID: 10537128
Cloning and characterization of hurpin (protease inhibitor 13): A new skin-specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family.
Abts HF, Welss T, Mirmohammadsadegh A, Köhrer K, Michel G, Ruzicka T
J Mol Biol. 1999
PubMed ID: 10512713
Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis.
Schuster V, Seidenspinner S, Zeitler P, Escher C, Pleyer U, Bernauer W, Stiehm ER, Isenberg S, Seregard S, Olsson T, Mingers AM, Schambeck C, Kreth HW
Blood. 1999
PubMed ID: 10233898
Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice.
Nagai N, De Mol M, Lijnen HR, Carmeliet P, Collen D
Circulation. 1999
PubMed ID: 10318667
Extrahepatic synthesis of plasminogen in the human cornea is up-regulated by interleukins-1alpha and -1beta.
Twining SS, Wilson PM, Ngamkitidechakul C
Biochem J. 1999
PubMed ID: 10215610
The cleavage site specificity of human prostate specific antigen for insulin-like growth factor binding protein-3.
Okabe E, Kajihara J, Usami Y, Hirano K
FEBS Lett. 1999
PubMed ID: 10218588
Angiostatin binds ATP synthase on the surface of human endothelial cells.
Moser TL, Stack MS, Asplin I, Enghild JJ, Højrup P, Everitt L, Hubchak S, Schnaper HW, Pizzo SV
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10077593
Growth and behavioral development in plasminogen gene-targeted mice.
Hoover-Plow J, Wang N, Ploplis V
Growth Dev Aging. 1999
PubMed ID: 10885855
Expression of plasminogen-related gene B varies among normal tissues and increases in cancer tissues.
Tateno T, Ichinose A
FEBS Lett. 1999
PubMed ID: 10069369
Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27.
Verhaagh S, Schweifer N, Barlow DP, Zwart R
Genomics. 1999
PubMed ID: 9933568
The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis.
Gebbia JA, Monco JC, Degen JL, Bugge TH, Benach JL
J Clin Invest. 1999
PubMed ID: 9884337
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Therapy with a purified plasminogen concentrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency.
Schott D, Dempfle CE, Beck P, Liermann A, Mohr-Pennert A, Goldner M, Mehlem P, Azuma H, Schuster V, Mingers AM, Schwarz HP, Kramer MD
N Engl J Med. 1998
PubMed ID: 9834305
Plasminogen Kanagawa-I, a novel missense mutation, is caused by the amino acid substitution G732R.
Higuchi Y, Furihata K, Ueno I, Ishikawa S, Okumura N, Tozuka M, Sakurai N
Br J Haematol. 1998
PubMed ID: 9858247
Reduced transplant arteriosclerosis in plasminogen-deficient mice.
Moons L, Shi C, Ploplis V, Plow E, Haber E, Collen D, Carmeliet P
J Clin Invest. 1998
PubMed ID: 9819364
The plasminogen binding site of the C-type lectin tetranectin is located in the carbohydrate recognition domain, and binding is sensitive to both calcium and lysine.
Graversen JH, Lorentsen RH, Jacobsen C, Moestrup SK, Sigurskjold BW, Thogersen HC, Etzerodt M
J Biol Chem. 1998
PubMed ID: 9786936
Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice.
Lou XJ, Boonmark NW, Horrigan FT, Degen JL, Lawn RM
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9770530
The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action.
Parry MA, Fernandez-Catalan C, Bergner A, Huber R, Hopfner KP, Schlott B, Gührs KH, Bode W
Nat Struct Biol. 1998
PubMed ID: 9783753
Identification of a meander region proline residue critical for heme binding to cytochrome P450: implications for the catalytic function of human CYP4B1.
Zheng YM, Fisher MB, Yokotani N, Fujii-Kuriyama Y, Rettie AE
Biochemistry. 1998
PubMed ID: 9737862
Plasminogen binds the heparin-binding domain of insulin-like growth factor-binding protein-3.
Campbell PG, Durham SK, Suwanichkul A, Hayes JD, Powell DR
Am J Physiol. 1998
PubMed ID: 9688635
Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice.
Bugge TH, Lund LR, Kombrinck KK, Nielsen BS, Holmbäck K, Drew AF, Flick MJ, Witte DP, Danø K, Degen JL
Oncogene. 1998
PubMed ID: 9671388
Plasmin can reduce the function of human beta2 glycoprotein I by cleaving domain V into a nicked form.
Ohkura N, Hagihara Y, Yoshimura T, Goto Y, Kato H
Blood. 1998
PubMed ID: 9596664
Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3).
Lijnen HR, Ugwu F, Bini A, Collen D
Biochemistry. 1998
PubMed ID: 9548733
Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice.
Ploplis VA, French EL, Carmeliet P, Collen D, Plow EF
Blood. 1998
PubMed ID: 9490683
Tissue factor regulates plasminogen binding and activation.
Fan Z, Larson PJ, Bognacki J, Raghunath PN, Tomaszewski JE, Kuo A, Canziani G, Chaiken I, Cines DB, Higazi AA
Blood. 1998
PubMed ID: 9490681
Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen.
Chang Y, Mochalkin I, McCance SG, Cheng B, Tulinsky A, Castellino FJ
Biochemistry. 1998
PubMed ID: 9521645
Ligneous conjunctivitis in plasminogen-deficient mice.
Drew AF, Kaufman AH, Kombrinck KW, Danton MJ, Daugherty CC, Degen JL, Bugge TH
Blood. 1998
PubMed ID: 9473227
Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis.
Melnick M, Chen H, Buckley S, Warburton D, Jaskoll T
Dev Dyn. 1998
PubMed ID: 9438420
High-molecular-mass and low-molecular-mass kininogens block plasmin-induced platelet aggregation by forming a complex with kringle 5 of plasminogen/plasmin.
Selim TE, Ghoneim HR, Uknis AB, Colman RW, DeLa Cadena RA
Eur J Biochem. 1997
PubMed ID: 9428707
Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice.
Bugge TH, Kombrinck KW, Xiao Q, Holmbäck K, Daugherty CC, Witte DP, Degen JL
Blood. 1997
PubMed ID: 9373263
Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9).
Patterson BC, Sang QA
J Biol Chem. 1997
PubMed ID: 9360944
Ala601-Thr type dysplasminogenaemia genetically diagnosed in patients with retinochoroidal vascular disorders.
Murata M, Ooe A, Izumi T, Nakagawa M, Takahashi S, Ishikawa M, Mori K, Ichinose A
Br J Haematol. 1997
PubMed ID: 9375744
Ligand preferences of kringle 2 and homologous domains of human plasminogen: canvassing weak, intermediate, and high-affinity binding sites by 1H-NMR.
Marti DN, Hu CK, An SS, von Haller P, Schaller J, Llinás M
Biochemistry. 1997
PubMed ID: 9305949
Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis.
Xiao Q, Danton MJ, Witte DP, Kowala MC, Valentine MT, Bugge TH, Degen JL
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9294211
Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin.
Tsirka SE, Bugge TH, Degen JL, Strickland S
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9275201
Proteolytic fragments of insulin-like growth factor binding protein-3: N-terminal sequences and relationships between structure and biological activity.
Lalou C, Sawamura S, Segovia B, Ogawa Y, Binoux M
C R Acad Sci III. 1997
PubMed ID: 9337997
Characterization of the C3 YAC contig from proximal mouse chromosome 17 and analysis of allelic expression of genes flanking the imprinted Igf2r gene.
Schweifer N, Valk PJ, Delwel R, Cox R, Francis F, Meier-Ewert S, Lehrach H, Barlow DP
Genomics. 1997
PubMed ID: 9268631
Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.
Schuster V, Mingers AM, Seidenspinner S, Nüssgens Z, Pukrop T, Kreth HW
Blood. 1997
PubMed ID: 9242524
Localization of somatostatin receptor genes on mouse chromosomes 2, 11, 12, 15, and 17: correlation with growth QTLs.
Brinkmeier ML, Camper SA
Genomics. 1997
PubMed ID: 9226367
Serine-578 is a major phosphorylation locus in human plasma plasminogen.
Wang H, Prorok M, Bretthauer RK, Castellino FJ
Biochemistry. 1997
PubMed ID: 9201958
Degradation of C1-inhibitor by plasmin: implications for the control of inflammatory processes.
Wallace EM, Perkins SJ, Sim RB, Willis AC, Feighery C, Jackson J
Mol Med. 1997
PubMed ID: 9234243
A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer.
Sim BK, O'Reilly MS, Liang H, Fortier AH, He W, Madsen JW, Lapcevich R, Nacy CA
Cancer Res. 1997
PubMed ID: 9102221
Evidence for a novel O-linked sialylated trisaccharide on Ser-248 of human plasminogen 2.
Pirie-Shepherd SR, Stevens RD, Andon NL, Enghild JJ, Pizzo SV
J Biol Chem. 1997
PubMed ID: 9054441
Structure of human plasminogen kringle 4 at 1.68 a and 277 K. A possible structural role of disordered residues.
Stec B, Yamano A, Whitlow M, Teeter MM
Acta Crystallogr D Biol Crystallogr. 1997
PubMed ID: 15299951
Acceleration of plasminogen activation by tissue plasminogen activator on surface-bound histidine-proline-rich glycoprotein.
Borza DB, Morgan WT
J Biol Chem. 1997
PubMed ID: 9102401
Interactions of mast cell tryptase with thrombin receptors and PAR-2.
Molino M, Barnathan ES, Numerof R, Clark J, Dreyer M, Cumashi A, Hoxie JA, Schechter N, Woolkalis M, Brass LF
J Biol Chem. 1997
PubMed ID: 9020112
An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus.
Tsirka SE, Rogove AD, Bugge TH, Degen JL, Strickland S
J Neurosci. 1997
PubMed ID: 8987777
Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency.
Bugge TH, Kombrinck KW, Flick MJ, Daugherty CC, Danton MJ, Degen JL
Cell. 1996
PubMed ID: 8929539
Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells.
Cao Y, Ji RW, Davidson D, Schaller J, Marti D, Söhndel S, McCance SG, O'Reilly MS, Llinás M, Folkman J
J Biol Chem. 1996
PubMed ID: 8910613
The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters.
Schweifer N, Barlow DP
Mamm Genome. 1996
PubMed ID: 8854860
IGFBP-3 proteolysis by plasmin, thrombin, serum: heparin binding, IGF binding, and structure of fragments.
Booth BA, Boes M, Bar RS
Am J Physiol. 1996
PubMed ID: 8843739
Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen.
Lijnen HR, Carmeliet P, Bouché A, Moons L, Ploplis VA, Plow EF, Collen D
Blood. 1996
PubMed ID: 8704243
Motifs resembling hepatocyte nuclear factor 1 and activator protein 3 mediate the tissue specificity of the human plasminogen gene.
Meroni G, Buraggi G, Mantovani R, Taramelli R
Eur J Biochem. 1996
PubMed ID: 8612605
Impaired wound healing in mice with a disrupted plasminogen gene.
Romer J, Bugge TH, Pyke C, Lund LR, Flick MJ, Degen JL, Dano K
Nat Med. 1996
PubMed ID: 8612226
Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid.
Mathews II, Vanderhoff-Hanaver P, Castellino FJ, Tulinsky A
Biochemistry. 1996
PubMed ID: 8611560
Recombinant gene expression and 1H NMR characteristics of the kringle (2 + 3) supermodule: spectroscopic/functional individuality of plasminogen kringle domains.
Söhndel S, Hu CK, Marti D, Affolter M, Schaller J, Llinás M, Rickli EE
Biochemistry. 1996
PubMed ID: 8652577
Inhibitory properties of a novel human Kunitz-type protease inhibitor homologous to tissue factor pathway inhibitor.
Petersen LC, Sprecher CA, Foster DC, Blumberg H, Hamamoto T, Kisiel W
Biochemistry. 1996
PubMed ID: 8555184
Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.
Ploplis VA, Carmeliet P, Vazirzadeh S, Van Vlaenderen I, Moons L, Plow EF, Collen D
Circulation. 1995
PubMed ID: 7586361
Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris.
Sun J, Coughlin P, Salem HH, Bird P
Biochim Biophys Acta. 1995
PubMed ID: 7548163
Interaction of human pregnancy-associated plasma protein-A with serine proteinases.
Zorin NA, Zhabin SG, Semenkov NN
Clin Chim Acta. 1995
PubMed ID: 7586586
Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.
Bugge TH, Flick MJ, Daugherty CC, Degen JL
Genes Dev. 1995
PubMed ID: 7705657
Characterization of plasminogen system on rat yolk sac carcinoma (L2) cells.
Kanalas JJ
Am J Physiol. 1995
PubMed ID: 7864083
Complement component C7 is a plasminogen-binding protein.
Reinartz J, Hänsch GM, Kramer MD
J Immunol. 1995
PubMed ID: 7814888
Osteonectin in matrix remodeling. A plasminogen-osteonectin-collagen complex.
Kelm RJ, Swords NA, Orfeo T, Mann KG
J Biol Chem. 1994
PubMed ID: 7982919
High-resolution genetic analysis of a deletion on mouse chromosome 17 extending over the fused, tufted, and homeobox Nkx2-5 loci.
Himmelbauer H, Harvey RP, Copeland NG, Jenkins NA, Silver LM
Mamm Genome. 1994
PubMed ID: 7894168
Biochemical analysis of prostate specific antigen-proteolyzed insulin-like growth factor binding protein-3.
Fielder PJ, Rosenfeld RG, Graves HC, Grandbois K, Maack CA, Sawamura S, Ogawa Y, Sommer A, Cohen P
Growth Regul. 1994
PubMed ID: 7538844
Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.
O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH, Folkman J
Cell. 1994
PubMed ID: 7525077
Molecular cloning, sequencing, chromosomal localization and expression of mouse p21 (Waf1).
Huppi K, Siwarski D, Dosik J, Michieli P, Chedid M, Reed S, Mock B, Givol D, Mushinski JF
Oncogene. 1994
PubMed ID: 8084607
Solution structure of the epsilon-aminohexanoic acid complex of human plasminogen kringle 1.
Rejante MR, Llinás M
Eur J Biochem. 1994
PubMed ID: 8181476
1H-NMR assignments and secondary structure of human plasminogen kringle 1.
Rejante MR, Llinás M
Eur J Biochem. 1994
PubMed ID: 8181475
The structure of recombinant plasminogen kringle 1 and the fibrin binding site.
Wu TP, Padmanabhan KP, Tulinsky A
Blood Coagul Fibrinolysis. 1994
PubMed ID: 8054447
Subregional mapping of 8 single copy loci to chromosome 6 by fluorescence in situ hybridization.
Rao PH, Murty VV, Gaidano G, Hauptschein R, Dalla-Favera R, Chaganti RS
Cytogenet Cell Genet. 1994
PubMed ID: 8162705
Detailed physical and genetic mapping in the region of plasminogen, D17Rp17e, and quaking.
Cox RD, Whittington J, Shedlovsky A, Connelly CS, Dove WF, Goldsworthy M, Larin Z, Lehrach H
Mamm Genome. 1993
PubMed ID: 8111116
The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator.
Moser TL, Enghild JJ, Pizzo SV, Stack MS
J Biol Chem. 1993
PubMed ID: 8360181
Congenital plasminogen deficiency caused by a Ser572 to Pro mutation.
Azuma H, Uno Y, Shigekiyo T, Saito S
Blood. 1993
PubMed ID: 8392398
High-resolution comparative mapping of mouse chromosome 17.
Himmelbauer H, Silver LM
Genomics. 1993
PubMed ID: 8406442
Familial association of high levels of histidine-rich glycoprotein and plasminogen activator inhibitor-1 with venous thromboembolism.
Angles-Cano E, Gris JC, Loyau S, Schved JF
J Lab Clin Med. 1993
PubMed ID: 8478593
Identification of a region of beta 2-glycoprotein I critical for lipid binding and anti-cardiolipin antibody cofactor activity.
Hunt JE, Simpson RJ, Krilis SA
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8460120
Plasminogen with type-I mutation is polymorphic in the Japanese population.
Kikuchi S, Yamanouchi Y, Li L, Kobayashi K, Ijima H, Miyazaki R, Tsuchiya S, Hamaguchi H
Hum Genet. 1992
PubMed ID: 1427790
Expression of murine cyclin B1 mRNAs and genetic mapping of related genomic sequences.
Hanley-Hyde J, Mushinski JF, Sadofsky M, Huppi K, Krall M, Kozak CA, Mock B
Genomics. 1992
PubMed ID: 1387105
Localization of the Mas proto-oncogene to a densely marked region of mouse chromosome 17 associated with genomic imprinting.
Cebra-Thomas JA, Tsai JY, Pilder SH, Copeland NG, Jenkins NA, Silver LM
Genomics. 1992
PubMed ID: 1612602
Genetic mapping of three human homologues of murine t-complex genes localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLG.
Blanché H, Wright LG, Vergnaud G, de Gouyon B, Lauthier V, Silver LM, Dausset J, Cann HM, Spielman RS
Genomics. 1992
PubMed ID: 1572657
The mouse plasminogen locus maps to the recombination breakpoints of the tLub2 and TtOrl partial t haplotypes but is not at the tw73 locus.
Schweifer N, Barlow DP
Mamm Genome. 1992
PubMed ID: 1543918
Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma.
Eaton DL, Malloy BE, Tsai SP, Henzel W, Drayna D
J Biol Chem. 1991
PubMed ID: 1939207
The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle 4.
Wu TP, Padmanabhan K, Tulinsky A, Mulichak AM
Biochemistry. 1991
PubMed ID: 1657149
Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-A resolution.
Mulichak AM, Tulinsky A, Ravichandran KG
Biochemistry. 1991
PubMed ID: 1657148
Interactions of plasminogen and tissue plasminogen activator (t-PA) with amphoterin. Enhancement of t-PA-catalyzed plasminogen activation by amphoterin.
Parkkinen J, Rauvala H
J Biol Chem. 1991
PubMed ID: 1909331
Structures of the asparagine-289-linked oligosaccharides assembled on recombinant human plasminogen expressed in a Mamestra brassicae cell line (IZD-MBO503).
Davidson DJ, Castellino FJ
Biochemistry. 1991
PubMed ID: 2065054
Identification of the rat Heymann nephritis autoantigen (GP330) as a receptor site for plasminogen.
Kanalas JJ, Makker SP
J Biol Chem. 1991
PubMed ID: 1645711
The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus.
Barlow DP, Stöger R, Herrmann BG, Saito K, Schweifer N
Nature. 1991
PubMed ID: 1845916
Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis.
Ichinose A, Espling ES, Takamatsu J, Saito H, Shinmyozu K, Maruyama I, Petersen TE, Davie EW
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1986355
Characterization of the cDNA coding for mouse plasminogen and localization of the gene to mouse chromosome 17.
Degen SJ, Bell SM, Schaefer LA, Elliott RW
Genomics. 1990
PubMed ID: 2081600
A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule.
Kirschbaum NE, Budzynski AZ
J Biol Chem. 1990
PubMed ID: 2143188
Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system.
Petersen TE, Martzen MR, Ichinose A, Davie EW
J Biol Chem. 1990
PubMed ID: 2318848
Solution structure of the kringle 4 domain from human plasminogen by 1H nuclear magnetic resonance spectroscopy and distance geometry.
Atkinson RA, Williams RJ
J Mol Biol. 1990
PubMed ID: 2157850
SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix.
Sage H, Vernon RB, Funk SE, Everitt EA, Angello J
J Cell Biol. 1989
PubMed ID: 2745554
Thrombospondin interaction with plasminogen. Evidence for binding to a specific region of the kringle structure of plasminogen.
DePoli P, Bacon-Baguley T, Kendra-Franczak S, Cederholm MT, Walz DA
Blood. 1989
PubMed ID: 2522013
The N- and O-linked carbohydrate chains of human, bovine and porcine plasminogen. Species specificity in relation to sialylation and fucosylation patterns.
Marti T, Schaller J, Rickli EE, Schmid K, Kamerling JP, Gerwig GJ, van Halbeek H, Vliegenthart JF
Eur J Biochem. 1988
PubMed ID: 3356193
Binding site of alpha 2-plasmin inhibitor to plasminogen.
Sugiyama N, Sasaki T, Iwamoto M, Abiko Y
Biochim Biophys Acta. 1988
PubMed ID: 3334852
Interaction of one-chain and two-chain tissue plasminogen activator with intact and plasmin-degraded fibrin.
Higgins DL, Vehar GA
Biochemistry. 1987
PubMed ID: 2962641
Structure and formation of microplasmin.
Wu HL, Shi GY, Wohl RC, Bender ML
Proc Natl Acad Sci U S A. 1987
PubMed ID: 2962191
Receptor mediated binding of the fibrinolytic components, plasminogen and urokinase, to peripheral blood cells.
Miles LA, Plow EF
Thromb Haemost. 1987
PubMed ID: 2829380
The reactive site of human alpha 2-antiplasmin.
Shieh BH, Travis J
J Biol Chem. 1987
PubMed ID: 2437112
Molecular cloning and characterization of a full-length cDNA clone for human plasminogen.
Forsgren M, Råden B, Israelsson M, Larsson K, Hedén LO
FEBS Lett. 1987
PubMed ID: 3030813
Binding and activation of plasminogen on the platelet surface.
Miles LA, Plow EF
J Biol Chem. 1985
PubMed ID: 3920216
The fibrin-binding site of human plasminogen. Arginines 32 and 34 are essential for fibrin affinity of the kringle 1 domain.
Váli Z, Patthy L
J Biol Chem. 1984
PubMed ID: 6094526
Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator.
Silverstein RL, Leung LL, Harpel PC, Nachman RL
J Clin Invest. 1984
PubMed ID: 6438154
Characterization of a complementary deoxyribonucleic acid coding for human and bovine plasminogen.
Malinowski DP, Sadler JE, Davie EW
Biochemistry. 1984
PubMed ID: 6148961
Plasminogens Tochigi II and Nagoya: two additional molecular defects with Ala-600----Thr replacement found in plasmin light chain variants.
Miyata T, Iwanaga S, Sakata Y, Aoki N, Takamatsu J, Kamiya T
J Biochem. 1984
PubMed ID: 6238949
Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule.
Takahashi N, Ortel TL, Putnam FW
Proc Natl Acad Sci U S A. 1984
PubMed ID: 6582496
Amino acid sequence analysis of the asparagine-288 region of the carbohydrate variants of human plasminogen.
Powell JR, Castellino FJ
Biochemistry. 1983
PubMed ID: 6838832
Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.
Miyata T, Iwanaga S, Sakata Y, Aoki N
Proc Natl Acad Sci U S A. 1982
PubMed ID: 6216475
Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase.
Brower MS, Harpel PC
J Biol Chem. 1982
PubMed ID: 6980881
Structure of the omega-aminocarboxylic acid-binding sites of human plasminogen. Arginine 70 and aspartic acid 56 are essential for binding of ligand by kringle 4.
Trexler M, Váli Z, Patthy L
J Biol Chem. 1982
PubMed ID: 6919539
Carbohydrate of the human plasminogen variants. III. Structure of the O-glycosidically linked oligosaccharide unit.
Hayes ML, Castellino FJ
J Biol Chem. 1979
PubMed ID: 479158
On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin.
Wiman B, Collen D
J Biol Chem. 1979
PubMed ID: 158022
Abnormal plasminogen. A hereditary molecular abnormality found in a patient with recurrent thrombosis.
Aoki N, Moroi M, Sakata Y, Yoshida N, Matsuda M
J Clin Invest. 1978
PubMed ID: 659588
Chemical evidence that proteolytic cleavage causes the heterogeneity present in human ceruloplasmin preparations.
Kingston IB, Kingston BL, Putnam FW
Proc Natl Acad Sci U S A. 1977
PubMed ID: 146197
Primary structure of the B-chain of human plasmin.
Wiman B
Eur J Biochem. 1977
PubMed ID: 142009
Isolation and characterization of alpha2-plasmin inhibitor from human plasma. A novel proteinase inhibitor which inhibits activator-induced clot lysis.
Moroi M, Aoki N
J Biol Chem. 1976
PubMed ID: 134998
Amino-acid sequence of the cyanogen-bromide fragment from human plasminogen that forms the linkage between the plasmin chains.
Wiman B, Wallén P
Eur J Biochem. 1975
PubMed ID: 126863
Structural relationship between "glutamic acid" and "lysine" forms of human plasminogen and their interaction with the NH2-terminal activation peptide as studied by affinity chromatography.
Wiman B, Wallén P
Eur J Biochem. 1975
PubMed ID: 122932
The primary structure of human plasminogen. II. The histidine loop of human plasmin: light (B) chain active center histidine sequence.
Robbins KC, Bernabe P, Arzadon L, Summaria L
J Biol Chem. 1973
PubMed ID: 4694729
Plasminogen: purification from human plasma by affinity chromatography.
Deutsch DG, Mertz ET
Science. 1970
PubMed ID: 5475635
Studies on the active center of human plasmin. Partial amino acid sequence of a peptide containing the active center serine residue.
Groskopf WR, Summaria L, Robbins KC
J Biol Chem. 1969
PubMed ID: 4240117
The peptide chains of human plasmin. Mechanism of activation of human plasminogen to plasmin.
Robbins KC, Summaria L, Hsieh B, Shah RJ
J Biol Chem. 1967
PubMed ID: 4226004

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	5340	18815	85253
EnsEMBL Gene(s)	ENSG00000122194	ENSMUSG00000059481	ENSRNOG00000017223
Unigene	Hs.143436	Mm.971	Rn.20178
Homologene	PLG	Plg	Plg
OMIM	173350	N/A	N/A
GeneCards	PLG	N/A	N/A
Beta Cell Genomics	DT.453213 DT.91748451 DT.95162938	DT.101352252 DT.102542318 DT.536790	N/A
Reactome	P00747	N/A	N/A
Plasma Peptide Atlas	ENSP00000308938	N/A	N/A
WikiGenes	5340	18815	85253

External resources from NIDDK Consortium Interconnectivity Network Top Help

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Interactor	Interactor	Sources	Classification	Pubmed IDs
PLG	PRDX4	IntAct	empirical	21988832
PLG	CHGA	HPRD	empirical	11342539
PLG	CP	HPRD	empirical	146197 6582496
PLG	CPB2	HPRD, BioGRID	empirical	1939207
PLG	MAPK14	IntAct	empirical	21988832
PLG	AMOT	HPRD	empirical	11257124
PLG	ENO1	HPRD, BioGRID	empirical	11169399
PLG	EP300	IntAct	empirical	21988832
PLG	F2R	HPRD	empirical	10978167
PLG	F2RL1	HPRD	empirical	12604689 10978167 9020112
PLG	F3	HPRD	empirical	9490681
PLG	F10	HPRD, BioGRID	empirical	11371191
PLG	FN1	BioGRID	empirical	8360181
PLG	CYFIP2	IntAct	empirical	21988832
PLG	LAMA1	HPRD, BioGRID	empirical	8360181
PLG	CXCL2	HPRD	empirical	10928473
PLG	ANXA2	HPRD	empirical	10077593
PLG	HMGB1	HPRD, BioGRID	empirical	1909331
PLG	HRG	HPRD, Reactome	empirical	8478593 3011081 9414276 6448849
PLG	IGF2	HPRD	empirical	15642732
PLG	IGFBP3	HPRD, BioGRID	empirical	7538844 8843739 9337997 9688635
PLG	IGHA1	IntAct	empirical	15174051
PLG	APOH	HPRD	empirical	9596664 8460120
PLG	KLK3	HPRD	empirical	10604721
PLG	KNG1	HPRD, BioGRID	empirical	9428707
PLG	LAMA3	HPRD	empirical	10956663
PLG	LAMA5	BioGRID	empirical	10956663
PLG	SMAD3	IntAct	empirical	21988832
PLG	SMAD4	IntAct	empirical	21988832
PLG	MEP1A	HPRD	empirical	12189145
PLG	MMP3	HPRD	empirical	9548733
PLG	MMP7	HPRD	empirical	9360944 9548733
PLG	MMP9	HPRD	empirical	9360944
PLG	SERPINC1	HPRD	empirical	10974350
PLG	NGF	HPRD	empirical	11729324
PLG	SERPINE1	HPRD, BioGRID	empirical	11113116
PLG	ATP5B	HPRD	empirical	10077593
PLG	PAPPA	HPRD, BioGRID	empirical	7586586
PLG	PCOLCE	HPRD	empirical	10625689
PLG	SERPINB6	HPRD	empirical	7548163
PLG	SERPINI1	HPRD	empirical	12228252
PLG	SERPINB13	HPRD	empirical	10512713
PLG	PLAT	HPRD	empirical	11928826
PLG	PLAU	HPRD	empirical	3920216 2829380 4226004
PLG	PLG	HPRD, Reactome	empirical	11729324 9737862
PLG	SERPINF2	HPRD, BioGRID	empirical	2437112 3334852 158022 134998
PLG	PRNP	HPRD	empirical	11100730
PLG	RAP2A	IntAct, BioGRID	empirical	18624398
PLG	RBBP6	IntAct, BioGRID	empirical	18624398
PLG	S100A10	HPRD, BioGRID	empirical	11939791
PLG	CDCP1	HPRD	empirical	14739293
PLG	SPARC	HPRD, BioGRID	empirical	2745554 7982919
PLG	THBS1	HPRD, BioGRID	empirical	2522013 6438154
PLG	SERPING1	HPRD	empirical	9234243
PLG	CLEC3B	HPRD	empirical	10964919
PLG	C7	HPRD, BioGRID	empirical	7814888
PLG	TFPI2	HPRD	empirical	8555184
PLG	RUVBL1	HPRD, BioGRID	empirical	11027681
PLG	YTHDC1	IntAct	empirical	21988832