PDPK1

Summary Top Help

Gene Description:

3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide dependent protein kinase 1

Synonyms:

PDPK1, PDK1, PRO0461, Pdk1, Pdpk1

Orthologs:

Human PDPK1 (protein-coding), Mouse Pdpk1 (protein-coding), Rat Pdpk1 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd23	Mouse	chr17:3924615..26319104	22.39	376

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr16:2587965..2653189 (65.22 kb) View in Genome Browser

(Mouse) NCBIM37 - chr17:24210647..24287891 (77.24 kb) View in Genome Browser

(Rat) RGSC3.4 - chr10:13329708..13394086 (64.38 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PDPK1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PDPK1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 8

Biocarta: 7

Reactome: 35

NCI-Nature Pathway Interaction Database: 21

Gene Ontology: 42

Publications from PubMed Top Help

Type 1 Diabetes Publications: 5

Publications: 260

Protein phosphatase 2A (PP2A)-specific ubiquitin ligase MID1 is a sequence-dependent regulator of translation efficiency controlling 3-phosphoinositide-dependent protein kinase-1 (PDPK-1).
Aranda-Orgillés B, Rutschow D, Zeller R, Karagiannidis AI, Köhler A, Chen C, Wilson T, Krause S, Roepcke S, Lilley D, Schneider R, Schweiger S
J Biol Chem. 2011
PubMed ID: 21930711
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis.
Goertz MJ, Wu Z, Gallardo TD, Hamra FK, Castrillon DH
J Clin Invest. 2011
PubMed ID: 21865646
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
PKC-ι promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway.
Desai S, Pillai P, Win-Piazza H, Acevedo-Duncan M
Biochim Biophys Acta. 2011
PubMed ID: 21419810
PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models.
Ellwood-Yen K, Keilhack H, Kunii K, Dolinski B, Connor Y, Hu K, Nagashima K, O'Hare E, Erkul Y, Di Bacco A, Gargano D, Shomer NH, Angagaw M, Leccese E, Andrade P, Hurd M, Shin MK, Vogt TF, Northrup A, Bobkova EV, Kasibhatla S, Bronson RT, Scott ML, Draetta G, Richon V, Kohl N, Blume-Jensen P, Andersen JN, Kraus M
Cancer Res. 2011
PubMed ID: 21493594
Light at night activates IGF-1R/PDK1 signaling and accelerates tumor growth in human breast cancer xenografts.
Wu J, Dauchy RT, Tirrell PC, Wu SS, Lynch DT, Jitawatanarat P, Burrington CM, Dauchy EM, Blask DE, Greene MW
Cancer Res. 2011
PubMed ID: 21310824
APOA-1 is a novel marker of erythroid cell maturation from hematopoietic stem cells in mice and humans.
Inoue T, Sugiyama D, Kurita R, Oikawa T, Kulkeaw K, Kawano H, Miura Y, Okada M, Suehiro Y, Takahashi A, Marumoto T, Inoue H, Komatsu N, Tani K
Stem Cell Rev. 2011
PubMed ID: 20376577
Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.
Macintyre AN, Finlay D, Preston G, Sinclair LV, Waugh CM, Tamas P, Feijoo C, Okkenhaug K, Cantrell DA
Immunity. 2011
PubMed ID: 21295499
Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor.
Nagashima K, Shumway SD, Sathyanarayanan S, Chen AH, Dolinski B, Xu Y, Keilhack H, Nguyen T, Wiznerowicz M, Li L, Lutterbach BA, Chi A, Paweletz C, Allison T, Yan Y, Munshi SK, Klippel A, Kraus M, Bobkova EV, Deshmukh S, Xu Z, Mueller U, Szewczak AA, Pan BS, Richon V, Pollock R, Blume-Jensen P, Northrup A, Andersen JN
J Biol Chem. 2011
PubMed ID: 21118801
Beneficial effect of insulin in hyperhomocysteinemia and diabetes mellitus-induced vascular endothelium dysfunction: role of phosphoinositide dependent kinase and protein kinase B.
Sharma S, Singh M, Sharma PL
Mol Cell Biochem. 2011
PubMed ID: 21069435
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.
Sundaresan NR, Pillai VB, Wolfgeher D, Samant S, Vasudevan P, Parekh V, Raghuraman H, Cunningham JM, Gupta M, Gupta MP
Sci Signal. 2011
PubMed ID: 21775285
Targeting PDK1 in cancer.
Raimondi C, Falasca M
Curr Med Chem. 2011
PubMed ID: 21568903
PPARδ activation acts cooperatively with 3-phosphoinositide-dependent protein kinase-1 to enhance mammary tumorigenesis.
Pollock CB, Yin Y, Yuan H, Zeng X, King S, Li X, Kopelovich L, Albanese C, Glazer RI
PLoS One. 2011
PubMed ID: 21297860
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance.
Wullschleger S, Sakamoto K, Johnstone L, Duce S, Fleming S, Alessi DR
Dis Model Mech. 2011
PubMed ID: 20959631
T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells.
Park SG, Mathur R, Long M, Hosh N, Hao L, Hayden MS, Ghosh S
Immunity. 2010
PubMed ID: 21074460
Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells.
Finlay DK, Kelly AP, Clarke R, Sinclair LV, Deak M, Alessi DR, Cantrell DA
J Immunol. 2010
PubMed ID: 20944007
Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis.
Zheng W, Gorre N, Shen Y, Noda T, Ogawa W, Lundin E, Liu K
EMBO Rep. 2010
PubMed ID: 20930845
Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer.
Slattery ML, Lundgreen A, Herrick JS, Wolff RK
Mutat Res. 2010
PubMed ID: 21035469
Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).
Mouton V, Toussaint L, Vertommen D, Gueuning MA, Maisin L, Havaux X, Sanchez-Canedo C, Bertrand L, Dequiedt F, Hemmings BA, Hue L, Rider MH
Biochem J. 2010
PubMed ID: 20687898
PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like growth factor-i-stimulated AKT activation and vascular smooth muscle cell survival.
Shen X, Xi G, Radhakrishnan Y, Clemmons DR
J Biol Chem. 2010
PubMed ID: 20643654
PDK1 plays a critical role in regulating cardiac function in mice and human.
Di RM, Feng QT, Chang Z, Luan Q, Zhang YY, Huang J, Li XL, Yang ZZ
Chin Med J (Engl). 2010
PubMed ID: 21034549
Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages.
Chaurasia B, Mauer J, Koch L, Goldau J, Kock AS, Brüning JC
Mol Cell Biol. 2010
PubMed ID: 20584979
Network organization of the human autophagy system.
Behrends C, Sowa ME, Gygi SP, Harper JW
Nature. 2010
PubMed ID: 20562859
PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.
Feng Q, Di R, Tao F, Chang Z, Lu S, Fan W, Shan C, Li X, Yang Z
Mol Cell Biol. 2010
PubMed ID: 20457809
Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening.
Bobkova EV, Weber MJ, Xu Z, Zhang YL, Jung J, Blume-Jensen P, Northrup A, Kunapuli P, Andersen JN, Kariv I
J Biol Chem. 2010
PubMed ID: 20385558
Mutational and immunohistochemical study of the PI3K/Akt pathway in papillary thyroid carcinoma in Greece.
Sozopoulos E, Litsiou H, Voutsinas G, Mitsiades N, Anagnostakis N, Tseva T, Patsouris E, Tseleni-Balafouta S
Endocr Pathol. 2010
PubMed ID: 20186503
PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake.
Iskandar K, Cao Y, Hayashi Y, Nakata M, Takano E, Yada T, Zhang C, Ogawa W, Oki M, Chua S, Itoh H, Noda T, Kasuga M, Nakae J
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 20103739
Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation.
Sanchez Canedo C, Demeulder B, Ginion A, Bayascas JR, Balligand JL, Alessi DR, Vanoverschelde JL, Beauloye C, Hue L, Bertrand L
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 20051528
3-phosphoinositide-dependent protein kinase-1 regulates proliferation and survival of cancer cells with an activated mitogen-activated protein kinase pathway.
Lu Z, Cox-Hipkin MA, Windsor WT, Boyapati A
Mol Cancer Res. 2010
PubMed ID: 20197379
Protein kinase C: poised to signal.
Newton AC
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 19934406
Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death.
Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
J Biol Chem. 2010
PubMed ID: 20044479
Initiation of neuronal differentiation requires PI3-kinase/TOR signalling in the vertebrate neural tube.
Fishwick KJ, Li RA, Halley P, Deng P, Storey KG
Dev Biol. 2010
PubMed ID: 20004186
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.
Ericson K, Gan C, Cheong I, Rago C, Samuels Y, Velculescu VE, Kinzler KW, Huso DL, Vogelstein B, Papadopoulos N
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133737
The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons.
Hryciw T, MacDonald JI, Phillips R, Seah C, Pasternak S, Meakin SO
J Neurochem. 2010
PubMed ID: 19943849
Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles.
Adhikari D, Zheng W, Shen Y, Gorre N, Hämäläinen T, Cooney AJ, Huhtaniemi I, Lan ZJ, Liu K
Hum Mol Genet. 2010
PubMed ID: 19843540
Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation.
Seong HA, Jung H, Ichijo H, Ha H
J Biol Chem. 2010
PubMed ID: 19920149
c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis.
Lopez-Bergami P, Kim H, Dewing A, Goydos J, Aaronson S, Ronai Z
J Biol Chem. 2010
PubMed ID: 19910471
Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells.
Shumilina E, Zemtsova IM, Heise N, Schmid E, Eichenmüller M, Tyan L, Rexhepaj R, Lang F
Cell Physiol Biochem. 2010
PubMed ID: 21063107
Regulation of 3-phosphoinositide-dependent protein kinase 1 activity by homodimerization in live cells.
Masters TA, Calleja V, Armoogum DA, Marsh RJ, Applebee CJ, Laguerre M, Bain AJ, Larijani B
Sci Signal. 2010
PubMed ID: 20978239
PI3 kinase and PDK1 in the regulation of the electrogenic intestinal dipeptide transport.
Rexhepaj R, Rotte A, Pasham V, Gu S, Kempe DS, Lang F
Cell Physiol Biochem. 2010
PubMed ID: 20511717
Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase.
Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, Davies MA, Westwick JK, Mills GB
PLoS One. 2010
PubMed ID: 20361045
Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats.
Kobayashi T, Taguchi K, Nemoto S, Nogami T, Matsumoto T, Kamata K
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19717727
Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation.
Waugh C, Sinclair L, Finlay D, Bayascas JR, Cantrell D
Mol Cell Biol. 2009
PubMed ID: 19703999
The nuclear localization of 3'-phosphoinositide-dependent kinase-1 is dependent on its association with the protein tyrosine phosphatase SHP-1.
Sephton CF, Zhang D, Lehmann TM, Pennington PR, Scheid MP, Mousseau DD
Cell Signal. 2009
PubMed ID: 19591923
Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes.
Finlay DK, Sinclair LV, Feijoo C, Waugh CM, Hagenbeek TJ, Spits H, Cantrell DA
J Exp Med. 2009
PubMed ID: 19808258
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1.
Oishi K, Watatani K, Itoh Y, Okano H, Guillemot F, Nakajima K, Gotoh Y
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19549840
PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles.
Reddy P, Adhikari D, Zheng W, Liang S, Hämäläinen T, Tohonen V, Ogawa W, Noda T, Volarevic S, Huhtaniemi I, Liu K
Hum Mol Genet. 2009
PubMed ID: 19423553
Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains.
Chalhoub N, Zhu G, Zhu X, Baker SJ
Genes Dev. 2009
PubMed ID: 19605683
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
A reduction in Pten tumor suppressor activity promotes ErbB-2-induced mouse prostate adenocarcinoma formation through the activation of signaling cascades downstream of PDK1.
Rodriguez OC, Lai EW, Vissapragada S, Cromelin C, Avetian M, Salinas P, Ramos H, Kallakury B, Casimiro M, Lisanti MP, Tanowitz HB, Pacak K, Glazer RI, Avantaggiati M, Albanese C
Am J Pathol. 2009
PubMed ID: 19443706
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
PDK1 coordinates survival pathways and beta-adrenergic response in the heart.
Ito K, Akazawa H, Tamagawa M, Furukawa K, Ogawa W, Yasuda N, Kudo Y, Liao CH, Yamamoto R, Sato T, Molkentin JD, Kasuga M, Noda T, Nakaya H, Komuro I
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19429709
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
HMGB1 is phosphorylated by classical protein kinase C and is secreted by a calcium-dependent mechanism.
Oh YJ, Youn JH, Ji Y, Lee SE, Lim KJ, Choi JE, Shin JS
J Immunol. 2009
PubMed ID: 19380828
IGF-I regulated phosphorylation and translocation of PDK-1 in neurons.
Alajajian BB, Fletcher L, Isgor E, Jimenez DF, Digicaylioglu M
Neuroreport. 2009
PubMed ID: 19276999
PKCdelta survival signaling in cells containing an activated p21Ras protein requires PDK1.
Xia S, Chen Z, Forman LW, Faller DV
Cell Signal. 2009
PubMed ID: 19146951
The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells.
Park SG, Schulze-Luehrman J, Hayden MS, Hashimoto N, Ogawa W, Kasuga M, Ghosh S
Nat Immunol. 2009
PubMed ID: 19122654
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
Cell. 2009
PubMed ID: 19167335
Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance.
Wang C, Liu M, Riojas RA, Xin X, Gao Z, Zeng R, Wu J, Dong LQ, Liu F
J Biol Chem. 2009
PubMed ID: 19047061
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Structure-Function analysis of the CTLA-4 interaction with PP2A.
Teft WA, Chau TA, Madrenas J
BMC Immunol. 2009
PubMed ID: 19405949
The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation.
Haga S, Ozaki M, Inoue H, Okamoto Y, Ogawa W, Takeda K, Akira S, Todo S
Hepatology. 2009
PubMed ID: 19065678
Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis.
Vejux A, Guyot S, Montange T, Riedinger JM, Kahn E, Lizard G
J Nutr Biochem. 2009
PubMed ID: 18495460
The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner.
Lim WG, Chen X, Liu JP, Tan BJ, Zhou S, Smith A, Lees N, Hou L, Gu F, Yu XY, Du Y, Smith D, Verma C, Liu K, Duan W
Arch Biochem Biophys. 2008
PubMed ID: 18835241
Requirement of 3-phosphoinositide-dependent protein kinase-1 for BDNF-mediated neuronal survival.
Kharebava G, Makonchuk D, Kalita KB, Zheng JJ, Hetman M
J Neurosci. 2008
PubMed ID: 18971483
Dissecting the role of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) signalling pathways.
Bayascas JR
Cell Cycle. 2008
PubMed ID: 18802401
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.
Kurata A, Katayama R, Watanabe T, Tsuruo T, Fujita N
Cancer Sci. 2008
PubMed ID: 18616680
Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression.
Block K, Eid A, Griendling KK, Lee DY, Wittrant Y, Gorin Y
J Biol Chem. 2008
PubMed ID: 18559349
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells.
Tamgüney T, Zhang C, Fiedler D, Shokat K, Stokoe D
Exp Cell Res. 2008
PubMed ID: 18514190
NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation.
Wittwer T, Schmitz ML
Biochem Biophys Res Commun. 2008
PubMed ID: 18439422
PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression.
Nakamura K, Sakaue H, Nishizawa A, Matsuki Y, Gomi H, Watanabe E, Hiramatsua R, Tamamori-Adachi M, Kitajima S, Noda T, Ogawa W, Kasuga M
J Biol Chem. 2008
PubMed ID: 18430722
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.
Bayascas JR, Wullschleger S, Sakamoto K, García-Martínez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, Lucocq JM, Alessi DR
Mol Cell Biol. 2008
PubMed ID: 18347057
PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response.
Belgardt BF, Husch A, Rother E, Ernst MB, Wunderlich FT, Hampel B, Klöckener T, Alessi D, Kloppenburg P, Brüning JC
Cell Metab. 2008
PubMed ID: 18396135
Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells.
Weisberg E, Banerji L, Wright RD, Barrett R, Ray A, Moreno D, Catley L, Jiang J, Hall-Meyers E, Sauveur-Michel M, Stone R, Galinsky I, Fox E, Kung AL, Griffin JD
Blood. 2008
PubMed ID: 18184863
Parvovirus interference with intracellular signalling: mechanism of PKCeta activation in MVM-infected A9 fibroblasts.
Lachmann S, Bär S, Rommelaere J, Nüesch JP
Cell Microbiol. 2008
PubMed ID: 18042254
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE.
Pinner S, Sahai E
Nat Cell Biol. 2008
PubMed ID: 18204440
Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.
Yang KJ, Shin S, Piao L, Shin E, Li Y, Park KA, Byun HS, Won M, Hong J, Kweon GR, Hur GM, Seok JH, Chun T, Brazil DP, Hemmings BA, Park J
J Biol Chem. 2008
PubMed ID: 18024423
3-phosphoinositide-dependent kinase 1 deficiency perturbs Toll-like receptor signaling events and actin cytoskeleton dynamics in dendritic cells.
Zaru R, Mollahan P, Watts C
J Biol Chem. 2008
PubMed ID: 17991746
Phosphatidylinositide dependent kinase deficiency increases anxiety and decreases GABA and serotonin abundance in the amygdala.
Ackermann TF, Hörtnagl H, Wolfer DP, Colacicco G, Sohr R, Lang F, Hellweg R, Lang UE
Cell Physiol Biochem. 2008
PubMed ID: 19088455
Role of PDK1 in regulation of gastric acid secretion.
Rotte A, Bhandaru M, Ackermann TF, Boini KM, Lang F
Cell Physiol Biochem. 2008
PubMed ID: 19088454
Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells.
Freeley M, Park J, Yang KJ, Wange RL, Volkov Y, Kelleher D, Long A
Cell Signal. 2007
PubMed ID: 17826953
3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis.
Hayashi T, Mo JH, Gong X, Rossetto C, Jang A, Beck L, Elliott GI, Kufareva I, Abagyan R, Broide DH, Lee J, Raz E
Proc Natl Acad Sci U S A. 2007
PubMed ID: 18003900
PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound.
Cen L, Hsieh FC, Lin HJ, Chen CS, Qualman SJ, Lin J
Br J Cancer. 2007
PubMed ID: 17848913
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
Phosphoinositide 3-kinases as a common platform for multi-hormone signaling.
Hirsch E, Costa C, Ciraolo E
J Endocrinol. 2007
PubMed ID: 17641274
Notch-induced T cell development requires phosphoinositide-dependent kinase 1.
Kelly AP, Finlay DK, Hinton HJ, Clarke RG, Fiorini E, Radtke F, Cantrell DA
EMBO J. 2007
PubMed ID: 17599070
Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D.
Wood CD, Kelly AP, Matthews SA, Cantrell DA
FEBS Lett. 2007
PubMed ID: 17617409
Post-translational modifications regulate distinct functions of CARMA1 and BCL10.
Thome M, Weil R
Trends Immunol. 2007
PubMed ID: 17468049
Investigation of interleukin 1beta-mediated regulation of NF-kappaB activation in colonic cells reveals divergence between PKB and PDK-transduced events.
Parhar K, Eivemark S, Assi K, Gómez-Muñoz A, Yee A, Salh B
Mol Cell Biochem. 2007
PubMed ID: 17136479
The role of PKC and PDK1 in monocyte lineage specification by Ras.
Pearn L, Fisher J, Burnett AK, Darley RL
Blood. 2007
PubMed ID: 17255356
3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins.
Seong HA, Jung H, Kim KT, Ha H
J Biol Chem. 2007
PubMed ID: 17327236
NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling.
Seong HA, Jung H, Ha H
J Biol Chem. 2007
PubMed ID: 17314099
Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1.
Okamoto Y, Ogawa W, Nishizawa A, Inoue H, Teshigawara K, Kinoshita S, Matsuki Y, Watanabe E, Hiramatsu R, Sakaue H, Noda T, Kasuga M
Diabetes. 2007
PubMed ID: 17267763
Essential role of PDK1 in regulating endothelial cell migration.
Primo L, di Blasio L, Roca C, Droetto S, Piva R, Schaffhausen B, Bussolino F
J Cell Biol. 2007
PubMed ID: 17371830
Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM
Mol Cell Proteomics. 2007
PubMed ID: 17114649
Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium.
Budas GR, Sukhodub A, Alessi DR, Jovanović A
FASEB J. 2006
PubMed ID: 17077284
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice.
Rexhepaj R, Grahammer F, Völkl H, Remy C, Wagner CA, Sandulache D, Artunc F, Henke G, Nammi S, Capasso G, Alessi DR, Lang F
FASEB J. 2006
PubMed ID: 17077298
Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse.
Sandu C, Artunc F, Palmada M, Rexhepaj R, Grahammer F, Hussain A, Yun C, Alessi DR, Lang F
Am J Physiol Gastrointest Liver Physiol. 2006
PubMed ID: 16825708
Impaired intestinal and renal glucose transport in PDK-1 hypomorphic mice.
Artunc F, Rexhepaj R, Völkl H, Grahammer F, Remy C, Sandulache D, Nasir O, Wagner CA, Alessi DR, Lang F
Am J Physiol Regul Integr Comp Physiol. 2006
PubMed ID: 16741145
Antigen receptor regulation of phosphoinositide-dependent kinase 1 pathways during thymocyte development.
Hinton HJ, Clarke RG, Cantrell DA
FEBS Lett. 2006
PubMed ID: 17027005
Regulation and function of IKK and IKK-related kinases.
Häcker H, Karin M
Sci STKE. 2006
PubMed ID: 17047224
Evaluation of approaches to generation of tissue-specific knock-in mice.
Bayascas JR, Sakamoto K, Armit L, Arthur JS, Alessi DR
J Biol Chem. 2006
PubMed ID: 16887794
Fused protein of deltaPKC activation loop and PDK1-interacting fragment (deltaAL-PIF) functions as a pseudosubstrate and an inhibitory molecule for PDK1 when expressed in cells.
Seki T, Irie N, Nakamura K, Sakaue H, Ogawa W, Kasuga M, Yamamoto H, Ohmori S, Saito N, Sakai N
Genes Cells. 2006
PubMed ID: 16923125
Steady-state kinetic mechanism of PDK1.
Gao X, Harris TK
J Biol Chem. 2006
PubMed ID: 16737971
A germline-specific class of small RNAs binds mammalian Piwi proteins.
Girard A, Sachidanandam R, Hannon GJ, Carmell MA
Nature. 2006
PubMed ID: 16751776
Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4.
Nirula A, Ho M, Phee H, Roose J, Weiss A
J Exp Med. 2006
PubMed ID: 16785309
Phosphoinositide-dependent kinase l (PDK1) haplo-insufficiency inhibits production of alpha/beta (alpha/beta) but not gamma delta (gamma/delta) T lymphocytes.
Kelly AP, Hinton HJ, Clarke RG, Cantrell DA
FEBS Lett. 2006
PubMed ID: 16563390
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta.
Nadra K, Anghel SI, Joye E, Tan NS, Basu-Modak S, Trono D, Wahli W, Desvergne B
Mol Cell Biol. 2006
PubMed ID: 16581799
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.
Inoue H, Ogawa W, Asakawa A, Okamoto Y, Nishizawa A, Matsumoto M, Teshigawara K, Matsuki Y, Watanabe E, Hiramatsu R, Notohara K, Katayose K, Okamura H, Kahn CR, Noda T, Takeda K, Akira S, Inui A, Kasuga M
Cell Metab. 2006
PubMed ID: 16581004
3-phosphoinositide-dependent protein kinase-1 activates the peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation.
Yin Y, Yuan H, Wang C, Pattabiraman N, Rao M, Pestell RG, Glazer RI
Mol Endocrinol. 2006
PubMed ID: 16150867
Phosphoproteomic analysis of the human pituitary.
Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F
Pituitary. 2006
PubMed ID: 16807684
3-phosphoinositide-dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases.
Xie Z, Yuan H, Yin Y, Zeng X, Bai R, Glazer RI
BMC Cancer. 2006
PubMed ID: 16551362
Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein.
Seong HA, Jung H, Choi HS, Kim KT, Ha H
J Biol Chem. 2005
PubMed ID: 16251192
Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer.
Lin HJ, Hsieh FC, Song H, Lin J
Br J Cancer. 2005
PubMed ID: 16288304
3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling.
Tanaka H, Fujita N, Tsuruo T
J Biol Chem. 2005
PubMed ID: 16207722
Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.
Fiory F, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F
Mol Cell Biol. 2005
PubMed ID: 16314505
In vivo role of the phosphate groove of PDK1 defined by knockin mutation.
Collins BJ, Deak M, Murray-Tait V, Storey KG, Alessi DR
J Cell Sci. 2005
PubMed ID: 16219676
Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice.
Bayascas JR, Leslie NR, Parsons R, Fleming S, Alessi DR
Curr Biol. 2005
PubMed ID: 16243031
RGS4 and RGS5 are in vivo substrates of the N-end rule pathway.
Lee MJ, Tasaki T, Moroi K, An JY, Kimura S, Davydov IV, Kwon YT
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16217033
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart.
Mora A, Sakamoto K, McManus EJ, Alessi DR
FEBS Lett. 2005
PubMed ID: 15961082
Mechanisms of reactive oxygen species-dependent downregulation of insulin receptor substrate-1 by angiotensin II.
Taniyama Y, Hitomi H, Shah A, Alexander RW, Griendling KK
Arterioscler Thromb Vasc Biol. 2005
PubMed ID: 15802620
Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.
Komander D, Kular G, Deak M, Alessi DR, van Aalten DM
J Biol Chem. 2005
PubMed ID: 15741170
PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation.
Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S
Science. 2005
PubMed ID: 15802604
Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation.
Scheid MP, Parsons M, Woodgett JR
Mol Cell Biol. 2005
PubMed ID: 15743829
Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development.
Di-Poï N, Ng CY, Tan NS, Yang Z, Hemmings BA, Desvergne B, Michalik L, Wahli W
Mol Cell Biol. 2005
PubMed ID: 15713628
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM
Science. 2005
PubMed ID: 15718470
Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure.
Mora A, Lipina C, Tronche F, Sutherland C, Alessi DR
Biochem J. 2005
PubMed ID: 15554902
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
The sequence and analysis of duplication-rich human chromosome 16.
Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G, Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E, Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM, Callen DF, Campbell CS, Campbell ML, Campbell EW, Caoile C, Challacombe JF, Chasteen LA, Chertkov O, Chi HC, Christensen M, Clark LM, Cohn JD, Denys M, Detter JC, Dickson M, Dimitrijevic-Bussod M, Escobar J, Fawcett JJ, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Goodwin LA, Grady DL, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Hildebrand CE, Huang W, Israni S, Jett J, Jewett PB, Kadner K, Kimball H, Kobayashi A, Krawczyk MC, Leyba T, Longmire JL, Lopez F, Lou Y, Lowry S, Ludeman T, Manohar CF, Mark GA, McMurray KL, Meincke LJ, Morgan J, Moyzis RK, Mundt MO, Munk AC, Nandkeshwar RD, Pitluck S, Pollard M, Predki P, Parson-Quintana B, Ramirez L, Rash S, Retterer J, Ricke DO, Robinson DL, Rodriguez A, Salamov A, Saunders EH, Scott D, Shough T, Stallings RL, Stalvey M, Sutherland RD, Tapia R, Tesmer JG, Thayer N, Thompson LS, Tice H, Torney DC, Tran-Gyamfi M, Tsai M, Ulanovsky LE, Ustaszewska A, Vo N, White PS, Williams AL, Wills PL, Wu JR, Wu K, Yang J, Dejong P, Bruce D, Doggett NA, Deaven L, Schmutz J, Grimwood J, Richardson P, Rokhsar DS, Eichler EE, Gilna P, Lucas SM, Myers RM, Rubin EM, Pennacchio LA
Nature. 2004
PubMed ID: 15616553
Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells.
Lim MA, Yang L, Zheng Y, Wu H, Dong LQ, Liu F
Oncogene. 2004
PubMed ID: 15531926
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling.
Lin X, Wang D
Semin Immunol. 2004
PubMed ID: 15541657
Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene.
Misra UK, Pizzo SV
J Cell Biochem. 2004
PubMed ID: 15389876
Puromycin-insensitive leucyl-specific aminopeptidase (PILSAP) binds and catalyzes PDK1, allowing VEGF-stimulated activation of S6K for endothelial cell proliferation and angiogenesis.
Yamazaki T, Akada T, Niizeki O, Suzuki T, Miyashita H, Sato Y
Blood. 2004
PubMed ID: 15187024
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.
King CC, Newton AC
J Biol Chem. 2004
PubMed ID: 15210700
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15302935
Nonobese diabetic CD4 lymphocytosis maps outside the MHC locus on chromosome 17.
Koarada S, Wu Y, Yim YS, Wakeland EW, Ridgway WM
Immunogenetics. 2004
PubMed ID: 15309345
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation.
McManus EJ, Collins BJ, Ashby PR, Prescott AR, Murray-Tait V, Armit LJ, Arthur JS, Alessi DR
EMBO J. 2004
PubMed ID: 15116068
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC
Anal Chem. 2004
PubMed ID: 15144186
Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration.
Weber DS, Taniyama Y, Rocic P, Seshiah PN, Dechert MA, Gerthoffer WT, Griendling KK
Circ Res. 2004
PubMed ID: 15059930
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.
Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ
Mol Cell. 2004
PubMed ID: 15125833
CARMA1, BCL-10 and MALT1 in lymphocyte development and activation.
Thome M
Nat Rev Immunol. 2004
PubMed ID: 15122200
The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development.
Hinton HJ, Alessi DR, Cantrell DA
Nat Immunol. 2004
PubMed ID: 15077109
PDK1, the master regulator of AGC kinase signal transduction.
Mora A, Komander D, van Aalten DM, Alessi DR
Semin Cell Dev Biol. 2004
PubMed ID: 15209375
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner.
Nilsen T, Slagsvold T, Skjerpen CS, Brech A, Stenmark H, Olsnes S
J Biol Chem. 2004
PubMed ID: 14604990
Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt.
Remy I, Michnick SW
Mol Cell Biol. 2004
PubMed ID: 14749367
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function.
Lim MA, Kikani CK, Wick MJ, Dong LQ
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14623982
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions.
Taniyama Y, Weber DS, Rocic P, Hilenski L, Akers ML, Park J, Hemmings BA, Alexander RW, Griendling KK
Mol Cell Biol. 2003
PubMed ID: 14585963
Mouse 3-phosphoinositide-dependent protein kinase-1 undergoes dimerization and trans-phosphorylation in the activation loop.
Wick MJ, Ramos FJ, Chen H, Quon MJ, Dong LQ, Liu F
J Biol Chem. 2003
PubMed ID: 12923190
Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes.
Sakaue H, Nishizawa A, Ogawa W, Teshigawara K, Mori T, Takashima Y, Noda T, Kasuga M
J Biol Chem. 2003
PubMed ID: 12855688
Eosinophil major basic protein stimulates neutrophil superoxide production by a class IA phosphoinositide 3-kinase and protein kinase C-zeta-dependent pathway.
Shenoy NG, Gleich GJ, Thomas LL
J Immunol. 2003
PubMed ID: 14500673
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia.
Mora A, Davies AM, Bertrand L, Sharif I, Budas GR, Jovanović S, Mouton V, Kahn CR, Lucocq JM, Gray GA, Jovanović A, Alessi DR
EMBO J. 2003
PubMed ID: 12970179
Transformation of mammary epithelial cells by 3-phosphoinositide- dependent protein kinase-1 activates beta-catenin and c-Myc, and down-regulates caveolin-1.
Xie Z, Zeng X, Waldman T, Glazer RI
Cancer Res. 2003
PubMed ID: 14500370
Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1.
Torbett NE, Casamassima A, Parker PJ
J Biol Chem. 2003
PubMed ID: 12783890
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation.
Collins BJ, Deak M, Arthur JS, Armit LJ, Alessi DR
EMBO J. 2003
PubMed ID: 12912918
Expression pattern of the Rsk2, Rsk4 and Pdk1 genes during murine embryogenesis.
Kohn M, Hameister H, Vogel M, Kehrer-Sawatzki H
Gene Expr Patterns. 2003
PubMed ID: 12711546
PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1.
Ivaska J, Bosca L, Parker PJ
Nat Cell Biol. 2003
PubMed ID: 12640464
Identification of a proline-rich Akt substrate as a 14-3-3 binding partner.
Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA
J Biol Chem. 2003
PubMed ID: 12524439
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein.
Scott MT, Ingram A, Ball KL
EMBO J. 2002
PubMed ID: 12485998
Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1.
Moore MJ, Kanter JR, Jones KC, Taylor SS
J Biol Chem. 2002
PubMed ID: 12372837
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Protein kinase C(mu) regulation of the JNK pathway is triggered via phosphoinositide-dependent kinase 1 and protein kinase C(epsilon).
Brändlin I, Eiseler T, Salowsky R, Johannes FJ
J Biol Chem. 2002
PubMed ID: 12223477
The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism.
Makris C, Voisin L, Giasson E, Tudan C, Kaplan DR, Meloche S
Oncogene. 2002
PubMed ID: 12420226
The Na(+)/H(+) exchanger regulatory factor 2 mediates phosphorylation of serum- and glucocorticoid-induced protein kinase 1 by 3-phosphoinositide-dependent protein kinase 1.
Chun J, Kwon T, Lee E, Suh PG, Choi EJ, Sun Kang S
Biochem Biophys Res Commun. 2002
PubMed ID: 12387817
Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3.
Sato S, Fujita N, Tsuruo T
J Biol Chem. 2002
PubMed ID: 12177059
A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.
Frödin M, Antal TL, Dümmler BA, Jensen CJ, Deak M, Gammeltoft S, Biondi RM
EMBO J. 2002
PubMed ID: 12374740
Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase.
Conus NM, Hannan KM, Cristiano BE, Hemmings BA, Pearson RB
J Biol Chem. 2002
PubMed ID: 12149249
Membrane localization of 3-phosphoinositide-dependent protein kinase-1 stimulates activities of Akt and atypical protein kinase C but does not stimulate glucose transport and glycogen synthesis in 3T3-L1 adipocytes.
Egawa K, Maegawa H, Shi K, Nakamura T, Obata T, Yoshizaki T, Morino K, Shimizu S, Nishio Y, Suzuki E, Kashiwagi A
J Biol Chem. 2002
PubMed ID: 12147684
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.
Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, Vinci F, Chiappetta G, Tsichlis P, Bellacosa A, Fusco A, Santoro M
Nat Med. 2002
PubMed ID: 12244303
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.
Scheid MP, Marignani PA, Woodgett JR
Mol Cell Biol. 2002
PubMed ID: 12167717
Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells.
Yuan ZQ, Feldman RI, Sun M, Olashaw NE, Coppola D, Sussman GE, Shelley SA, Nicosia SV, Cheng JQ
J Biol Chem. 2002
PubMed ID: 12048203
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.
Biondi RM, Komander D, Thomas CC, Lizcano JM, Deak M, Alessi DR, van Aalten DM
EMBO J. 2002
PubMed ID: 12169624
Characterization of PDK2 activity against protein kinase B gamma.
Hodgkinson CP, Sale EM, Sale GJ
Biochemistry. 2002
PubMed ID: 12162751
Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription.
Kane LP, Mollenauer MN, Xu Z, Turck CW, Weiss A
Mol Cell Biol. 2002
PubMed ID: 12138205
Essential role of PDK1 in regulating cell size and development in mice.
Lawlor MA, Mora A, Ashby PR, Williams MR, Murray-Tait V, Malone L, Prescott AR, Lucocq JM, Alessi DR
EMBO J. 2002
PubMed ID: 12110585
Role of PDK1 in insulin-signaling pathway for glucose metabolism in 3T3-L1 adipocytes.
Yamada T, Katagiri H, Asano T, Tsuru M, Inukai K, Ono H, Kodama T, Kikuchi M, Oka Y
Am J Physiol Endocrinol Metab. 2002
PubMed ID: 12006370
Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta.
Dong LQ, Ramos FJ, Wick MJ, Lim MA, Guo Z, Strong R, Richardson A, Liu F
Biochem Biophys Res Commun. 2002
PubMed ID: 12054753
Substitution of the autophosphorylation site Thr516 with a negatively charged residue confers constitutive activity to mouse 3-phosphoinositide-dependent protein kinase-1 in cells.
Wick MJ, Wick KR, Chen H, He H, Dong LQ, Quon MJ, Liu F
J Biol Chem. 2002
PubMed ID: 11877406
Regulation of novel protein kinase C epsilon by phosphorylation.
Cenni V, Döppler H, Sonnenburg ED, Maraldi N, Newton AC, Toker A
Biochem J. 2002
PubMed ID: 11964154
Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI.
Barry FA, Gibbins JM
J Biol Chem. 2002
PubMed ID: 11825911
Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.
Fujita N, Sato S, Ishida A, Tsuruo T
J Biol Chem. 2002
PubMed ID: 11779851
PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism.
Tian X, Rusanescu G, Hou W, Schaffhausen B, Feig LA
EMBO J. 2002
PubMed ID: 11889038
Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment.
Hodgkinson CP, Sale GJ
Biochemistry. 2002
PubMed ID: 11781095
Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha.
Minami T, Hara K, Oshiro N, Ueoku S, Yoshino K, Tokunaga C, Shirai Y, Saito N, Gout I, Yonezawa K
Genes Cells. 2001
PubMed ID: 11733037
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation.
Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC
Nat Cell Biol. 2001
PubMed ID: 11715018
Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity.
Park J, Hill MM, Hess D, Brazil DP, Hofsteenge J, Hemmings BA
J Biol Chem. 2001
PubMed ID: 11481331
Regulation of Akt/PKB activation by tyrosine phosphorylation.
Chen R, Kim O, Yang J, Sato K, Eisenmann KM, McCarthy J, Chen H, Qiu Y
J Biol Chem. 2001
PubMed ID: 11445557
Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343.
Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S
J Biol Chem. 2001
PubMed ID: 11313365
Visualization of biochemical networks in living cells.
Remy I, Michnick SW
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11438723
Phosphorylation sites of protein kinase C delta in H2O2-treated cells and its activation by tyrosine kinase in vitro.
Konishi H, Yamauchi E, Taniguchi H, Yamamoto T, Matsuzaki H, Takemura Y, Ohmae K, Kikkawa U, Nishizuka Y
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11381116
The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1.
Gao T, Toker A, Newton AC
J Biol Chem. 2001
PubMed ID: 11376011
Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C.
Matsumoto M, Ogawa W, Hino Y, Furukawa K, Ono Y, Takahashi M, Ohba M, Kuroki T, Kasuga M
J Biol Chem. 2001
PubMed ID: 11278835
Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical protein kinase C-zeta.
Rafty LA, Khachigian LM
Nucleic Acids Res. 2001
PubMed ID: 11222751
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
B-cell development in progressively transformed germinal centers: similarities and differences compared with classical germinal centers and lymphocyte-predominant Hodgkin disease.
Bräuninger A, Yang W, Wacker HH, Rajewsky K, Küppers R, Hansmann ML
Blood. 2001
PubMed ID: 11157489
p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).
King CC, Gardiner EM, Zenke FT, Bohl BP, Newton AC, Hemmings BA, Bokoch GM
J Biol Chem. 2000
PubMed ID: 10995762
Changes in protein kinase C epsilon phosphorylation status and intracellular localization as 3T3 and 3T6 fibroblasts grow to confluency and quiescence: a role for phosphorylation at ser-729?
England K, Rumsby MG
Biochem J. 2000
PubMed ID: 11062054
Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP.
Takahashi M, Mukai H, Oishi K, Isagawa T, Ono Y
J Biol Chem. 2000
PubMed ID: 10945988
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding.
Kirk RI, Sanderson MR, Lerea KM
J Biol Chem. 2000
PubMed ID: 10896934
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1.
Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR
J Biol Chem. 2000
PubMed ID: 10764742
A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.
Frödin M, Jensen CJ, Merienne K, Gammeltoft S
EMBO J. 2000
PubMed ID: 10856237
Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton.
Dong LQ, Landa LR, Wick MJ, Zhu L, Mukai H, Ono Y, Liu F
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10792047
Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase.
Flynn P, Mellor H, Casamassima A, Parker PJ
J Biol Chem. 2000
PubMed ID: 10753910
The PI3K-PDK1 connection: more than just a road to PKB.
Vanhaesebroeck B, Alessi DR
Biochem J. 2000
PubMed ID: 10698680
Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA.
Biondi RM, Cheung PC, Casamayor A, Deak M, Currie RA, Alessi DR
EMBO J. 2000
PubMed ID: 10698939
Expression cloning of protein targets for 3-phosphorylated phosphoinositides.
Rao VR, Corradetti MN, Chen J, Peng J, Yuan J, Prestwich GD, Brugge JS
J Biol Chem. 1999
PubMed ID: 10608855
Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252.
Balendran A, Currie R, Armstrong CG, Avruch J, Alessi DR
J Biol Chem. 1999
PubMed ID: 10601311
Potential role of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in insulin-stimulated glucose transporter 4 translocation in adipocytes.
Grillo S, Grémeaux T, Le Marchand-Brustel Y, Tanti J
FEBS Lett. 1999
PubMed ID: 10567711
Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.
Kobayashi T, Deak M, Morrice N, Cohen P
Biochem J. 1999
PubMed ID: 10548550
90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.
Jensen CJ, Buch MB, Krag TO, Hemmings BA, Gammeltoft S, Frödin M
J Biol Chem. 1999
PubMed ID: 10480933
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase.
Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB
Nature. 1999
PubMed ID: 10485710
Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo.
Casamayor A, Morrice NA, Alessi DR
Biochem J. 1999
PubMed ID: 10455013
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.
Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G
Genes Dev. 1999
PubMed ID: 10364160
Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway.
Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA
EMBO J. 1999
PubMed ID: 10357815
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Downes CP, Alessi DR
Curr Biol. 1999
PubMed ID: 10226025
Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.
Kobayashi T, Cohen P
Biochem J. 1999
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Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta.
Dong LQ, Zhang RB, Langlais P, He H, Clark M, Zhu L, Liu F
J Biol Chem. 1999
PubMed ID: 10075713
Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.
Currie RA, Walker KS, Gray A, Deak M, Casamayor A, Downes CP, Cohen P, Alessi DR, Lucocq J
Biochem J. 1999
PubMed ID: 9895304
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Regulation of cell death protease caspase-9 by phosphorylation.
Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC
Science. 1998
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Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ
Science. 1998
PubMed ID: 9748166
Regulation of protein kinase C zeta by PI 3-kinase and PDK-1.
Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS, Newton AC, Schaffhausen BS, Toker A
Curr Biol. 1998
PubMed ID: 9768361
Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase.
Cheng X, Ma Y, Moore M, Hemmings BA, Taylor SS
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9707564
Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B.
Anderson KE, Coadwell J, Stephens LR, Hawkins PT
Curr Biol. 1998
PubMed ID: 9637919
Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.
Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR
Biochem J. 1998
PubMed ID: 9512493
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.
Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, Coadwell J, Hawkins PT
Science. 1998
PubMed ID: 9445477
Phosphorylation and activation of p70s6k by PDK1.
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G
Science. 1998
PubMed ID: 9445476
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK.
Dalby KN, Morrice N, Caudwell FB, Avruch J, Cohen P
J Biol Chem. 1998
PubMed ID: 9430688
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.
Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J
Curr Biol. 1998
PubMed ID: 9427642
Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta.
Meier R, Alessi DR, Cron P, Andjelković M, Hemmings BA
J Biol Chem. 1997
PubMed ID: 9374542
Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216.
Shaw M, Cohen P, Alessi DR
FEBS Lett. 1997
PubMed ID: 9373175
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.
del Peso L, González-García M, Page C, Herrera R, Nuñez G
Science. 1997
PubMed ID: 9381178
Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
Gene. 1997
PubMed ID: 9373149
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.
Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M
Curr Biol. 1997
PubMed ID: 9368760
Dual requirement for a newly identified phosphorylation site in p70s6k.
Moser BA, Dennis PB, Pullen N, Pearson RB, Williamson NA, Wettenhall RE, Kozma SC, Thomas G
Mol Cell Biol. 1997
PubMed ID: 9271440
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P
Curr Biol. 1997
PubMed ID: 9094314
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
PubMed ID: 8125298

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	5170	18607	81745
EnsEMBL Gene(s)	ENSG00000140992	ENSMUSG00000024122	ENSRNOG00000006136
Unigene	Hs.459691	Mm.10504	Rn.10905
Homologene	PDPK1	Pdpk1	Pdpk1
OMIM	605213	N/A	N/A
GeneCards	PDPK1	N/A	N/A
Beta Cell Genomics	DT.100025648 DT.100785196 DT.449221 DT.95374105	DT.528394 DT.91401094 DT.97371476	N/A
Reactome	O15530	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	5170	18607	81745

External resources from NIDDK Consortium Interconnectivity Network Top Help

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Interactor	Interactor	Sources	Classification	Pubmed IDs
PDPK1	AKT3	HPRD	empirical	12162751 9512493
PDPK1	SGK2	HPRD	empirical	10548550
PDPK1	G3BP1	IntAct	empirical	20562859
PDPK1	YWHAQ	HPRD, MINT	empirical	12177059
PDPK1	PRSS23	HPRD, MINT, IntAct	empirical	16169070
PDPK1	STRAP	HPRD	empirical	16251192
PDPK1	DDX42	MINT, IntAct	empirical	15102471
PDPK1	PARP1	MINT, IntAct	empirical	15102471
PDPK1	CDAN1	HPRD, MINT, IntAct	empirical	16169070
PDPK1	CST3	MINT, IntAct	empirical	15102471
PDPK1	AKT1	HPRD, MINT, IntAct, Reactome	empirical	11825911 11438723 10698680 12149249 11445557 14500673 11278835 9368760 10226025 21775285 7637810 9736715 15718470
PDPK1	AKT2	HPRD	empirical	12048203 9374542 9512493
PDPK1	PTK2B	HPRD	empirical	14585963
PDPK1	ALDOA	MINT, IntAct	empirical	15102471
PDPK1	SGK3	HPRD	empirical	10548550
PDPK1	MTOR	HPRD, MINT	empirical	11438723
PDPK1	PTPN22	IntAct	empirical	19167335
PDPK1	TBL2	IntAct	empirical	20562859
PDPK1	SND1	IntAct	empirical	20562859
PDPK1	GRIN1	IntAct	empirical	16635246
PDPK1	GRIN2B	IntAct	empirical	16635246
PDPK1	BIRC3	MINT, IntAct	empirical	15102471
PDPK1	HSP90AA1	HPRD	empirical	11779851
PDPK1	IGHG1	IntAct	empirical	15174051
PDPK1	ILK	HPRD	empirical	11313365
PDPK1	IRS1	HPRD	empirical	15802620
PDPK1	ITGB3	HPRD	empirical	10896934
PDPK1	PA2G4	IntAct	empirical	20562859
PDPK1	PAK1	HPRD	empirical	10995762
PDPK1	ATP5B	MINT, IntAct	empirical	15102471
PDPK1	PDE4B	MINT, IntAct	empirical	15102471
PDPK1	PDPK1	HPRD, IntAct	empirical	10455013 15144186 11481331 20562859
PDPK1	PFDN5	MINT, IntAct	empirical	15102471
PDPK1	ATP6V0C	MINT, IntAct	empirical	15102471
PDPK1	PNN	IntAct	empirical	16169070
PDPK1	PAF1	MINT, IntAct	empirical	15102471
PDPK1	PPP2R2B	IntAct	empirical	21075311
PDPK1	PPT1	MINT, IntAct	empirical	15102471
PDPK1	PRKACA	HPRD	empirical	10698939
PDPK1	PRKCB	HPRD	empirical	11376011
PDPK1	PRKCD	HPRD	empirical	11781095 11381116 9748166
PDPK1	PRKCE	HPRD	empirical	11062054 12640464 10945988
PDPK1	PRKCI	HPRD	empirical	10764742
PDPK1	PKN1	HPRD	empirical	10764742 10792047 10753910
PDPK1	PKN2	HPRD	empirical	10753910
PDPK1	PRKCZ	HPRD	empirical	11781095 9748166 10764742 11222751 14500673 10357815
PDPK1	PTPN12	IntAct	empirical	19167335
PDPK1	PTPRB	IntAct	empirical	19167335
PDPK1	PTPRC	IntAct	empirical	19167335
PDPK1	PTPRG	IntAct	empirical	19167335
PDPK1	PTPRJ	IntAct	empirical	19167335
PDPK1	PTPRK	IntAct	empirical	19167335
PDPK1	ACTA1	MINT	empirical
PDPK1	PTPRO	IntAct	empirical	19167335
PDPK1	PXN	HPRD	empirical	14585963
PDPK1	RALGDS	HPRD	empirical	11889038
PDPK1	RPN1	MINT, IntAct	empirical	15102471
PDPK1	RPS6KA1	HPRD	empirical	10480933 9430688
PDPK1	RPS6KA3	HPRD	empirical	10856237
PDPK1	RPS6KB1	HPRD, MINT	empirical	11438723 10601311 9271440 9445476 9427642
PDPK1	RPS6KB2	HPRD	empirical	11733037
PDPK1	AKTIP	HPRD	empirical	14749367
PDPK1	SGK1	HPRD, IntAct	empirical	10357815 10191262 17314099
PDPK1	SRC	HPRD	empirical	11481331
PDPK1	ACTC1	IntAct	empirical	15102471
PDPK1	ACTG1	IntAct	empirical	15102471
PDPK1	TOP2A	MINT, IntAct	empirical	15102471
PDPK1	YWHAH	HPRD, MINT	empirical	12177059
PDPK1	CARD11	HPRD	empirical	15802604
PDPK1	SLC9A3R2	HPRD	empirical	12387817
PDPK1	TOMM70A	MINT, IntAct	empirical	15102471