Home PDGFRB
|
Regions Overlapping this Feature:
Rat: 1
Other Regions: 1 Available
Other Regions: 1 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes |
|---|---|---|---|---|
| Iddm35 | Rat | chr18:4320091..76880933 | 72.56 | 466 |
(Human) GRCh37 - chr5:149493400..149535423 (422 kb) View in Genome Browser
(Mouse) NCBIM37 - chr18:61204804..61244721 (39.92 kb) View in Genome Browser
(Rat) RGSC3.4 - chr18:57014475..57053581 (39.11 kb) View in Genome Browser
HaemAtlas Expression Table for PDGFRB:|
Expression Legend
|
|
|
Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
| Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Expression Legend
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for PDGFRB:The PDGFRB interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| PDGFRB | PDCD6IP | BioGRID | empirical | 17082185 |
| PDGFRB | VAV3 | BioGRID | empirical | 10938113 |
| PDGFRB | PDAP1 | HPRD | empirical | 11331882 |
| PDGFRB | COPA | HPRD, BioGRID | empirical | 9207175 |
| PDGFRB | COPB1 | HPRD | empirical | 9207175 |
| PDGFRB | CRK | HPRD, BioGRID | empirical | 10733900 |
| PDGFRB | ADRBK1 | BioGRID | empirical | 12381737 |
| PDGFRB | S1PR1 | HPRD, BioGRID | empirical | 12480944 |
| PDGFRB | EGFR | HPRD, BioGRID | empirical | 9506992 |
| PDGFRB | FYN | HPRD | empirical | 1696179 9425276 |
| PDGFRB | GAB1 | HPRD | empirical | 14973141 |
| PDGFRB | PTPN22 | IntAct | empirical | 19167335 |
| PDGFRB | GRB2 | HPRD, BioGRID | empirical | 7935391 9362449 10026169 |
| PDGFRB | GRB7 | HPRD | empirical | 8940081 |
| PDGFRB | GRB10 | HPRD | empirical | 9006901 |
| PDGFRB | GRB14 | HPRD, BioGRID | empirical | 8647858 |
| PDGFRB | SH3KBP1 | BioGRID | empirical | 12177062 |
| PDGFRB | ARAF | HPRD | empirical | 15763428 |
| PDGFRB | ITGB3 | HPRD, BioGRID | empirical | 10964931 |
| PDGFRB | JAK1 | HPRD | empirical | 8657151 9484840 |
| PDGFRB | JAK2 | HPRD | empirical | 8657151 9484840 |
| PDGFRB | MFGE8 | BioGRID | empirical | 21868707 |
| PDGFRB | NCK1 | HPRD, BioGRID | empirical | 9362449 1333047 10026169 |
| PDGFRB | PDGFB | HPRD, IntAct | empirical | 11903042 17981115 |
| PDGFRB | PDGFRA | HPRD, BioGRID, Reactome | empirical | 2542288 7523122 2161888 1847074 |
| PDGFRB | PDGFRB | HPRD, BioGRID | empirical | 10821867 9207175 8195171 8617789 7935391 8940081 12062403 10391677 7523122 11046132 |
| PDGFRB | ATP6V0C | MINT | empirical | 1334459 |
| PDGFRB | PIK3C2B | HPRD, IntAct | empirical | 10805725 |
| PDGFRB | PIK3CA | HPRD | empirical | 8702949 |
| PDGFRB | PIK3R1 | HPRD, IntAct, BioGRID | empirical | 10697503 1372092 15377662 |
| PDGFRB | PIK3R2 | HPRD | empirical | 11172806 |
| PDGFRB | PLCG1 | HPRD, BioGRID | empirical | 8443409 17620338 |
| PDGFRB | MAPK3 | MINT | empirical | 19935650 |
| PDGFRB | EIF2AK2 | HPRD | empirical | 11350938 |
| PDGFRB | PTEN | MINT | empirical | 16456542 |
| PDGFRB | BAG1 | HPRD | empirical | 8947043 |
| PDGFRB | PTK2 | HPRD | empirical | 10806474 |
| PDGFRB | PTPN1 | HPRD, MINT, IntAct | empirical | 7545675 18515860 9355745 19167335 |
| PDGFRB | PTPN2 | HPRD | empirical | 14966296 15588985 |
| PDGFRB | PTPN6 | IntAct | empirical | 19167335 |
| PDGFRB | PTPN11 | HPRD, MINT, BioGRID | empirical | 7691811 12681492 8041791 7545675 11266449 |
| PDGFRB | PTPN12 | IntAct | empirical | 19167335 21376233 |
| PDGFRB | PTPRB | IntAct | empirical | 19167335 |
| PDGFRB | PTPRC | IntAct | empirical | 19167335 |
| PDGFRB | PTPRE | IntAct | empirical | 19167335 |
| PDGFRB | PTPRG | IntAct | empirical | 19167335 |
| PDGFRB | PTPRJ | HPRD, MINT, IntAct | empirical | 12062403 10821867 19167335 |
| PDGFRB | PTPRK | IntAct | empirical | 19167335 |
| PDGFRB | PTPRO | IntAct | empirical | 19167335 |
| PDGFRB | PTPRR | IntAct | empirical | 19167335 |
| PDGFRB | RAF1 | HPRD, BioGRID | empirical | 2475255 |
| PDGFRB | RASA1 | HPRD, BioGRID | empirical | 10697503 11896619 |
| PDGFRB | SHC1 | HPRD, BioGRID | empirical | 8195171 |
| PDGFRB | SNX1 | HPRD, BioGRID | empirical | 9819414 |
| PDGFRB | SNX2 | HPRD, BioGRID | empirical | 9819414 |
| PDGFRB | SRC | HPRD, BioGRID | empirical | 2173144 17158602 |
| PDGFRB | STAT1 | HPRD | empirical | 9484840 8549654 |
| PDGFRB | STAT3 | HPRD | empirical | 9484840 |
| PDGFRB | STAT5A | HPRD | empirical | 9484840 |
| PDGFRB | STAT5B | HPRD | empirical | 9484840 |
| PDGFRB | PRDX2 | HPRD | empirical | 15902258 |
| PDGFRB | TYK2 | HPRD | empirical | 8657151 9484840 |
| PDGFRB | UBC | BioGRID | empirical | 12717448 12381737 19696027 19644140 21139048 |
| PDGFRB | VAV1 | BioGRID | empirical | 10938113 |
| PDGFRB | VAV2 | BioGRID | empirical | 10938113 |
| PDGFRB | YES1 | HPRD | empirical | 7685273 |
| PDGFRB | PDGFD | HPRD | empirical | 14514732 |
| PDGFRB | KRTAP4-12 | HPRD, MINT, IntAct, BioGRID | empirical | 16189514 |
| PDGFRB | NCK2 | HPRD, BioGRID | empirical | 11027258 9737977 10026169 9843575 |
| PDGFRB | PIK3R3 | HPRD | empirical | 11172806 |
| PDGFRB | CAV1 | BioGRID | empirical | 10066366 |
| PDGFRB | CAV3 | BioGRID | empirical | 10066366 |
| PDGFRB | SOCS1 | HPRD | empirical | 10022833 |
| PDGFRB | CBL | HPRD, BioGRID | empirical | 10514377 10347229 17620338 |
| PDGFRB | SNX4 | HPRD, BioGRID | empirical | 9819414 |
| PDGFRB | SYNGAP1 | HPRD | empirical | 1374684 |
| PDGFRB | SLC9A3R2 | MINT | empirical | 16456542 |
| PDGFRB | SLC9A3R1 | HPRD, MINT, BioGRID | empirical | 11046132 16456542 |
|
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
Type 1 Diabetes Publications: 5
-
Deletion of platelet-derived growth factor receptor-β improves diabetic nephropathy in Ca²⁺/calmodulin-dependent protein kinase IIα (Thr286Asp) transgenic mice.
Suzuki H, Usui I, Kato I, Oya T, Kanatani Y, Yamazaki Y, Fujisaka S, Senda S, Ishii Y, Urakaze M, Mahmood A, Takasawa S, Okamoto H, Kobayashi M, Tobe K, Sasahara M
Diabetologia. 2011
PubMed ID: 21833587
-
Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells.
Wagner B, Ricono JM, Gorin Y, Block K, Arar M, Riley D, Choudhury GG, Abboud HE
J Am Soc Nephrol. 2007
PubMed ID: 17942966
-
PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival.
Song S, Ewald AJ, Stallcup W, Werb Z, Bergers G
Nat Cell Biol. 2005
PubMed ID: 16113679
-
Induction of platelet-derived growth factor A and B chains and over-expression of their receptors in human pancreatic cancer.
Ebert M, Yokoyama M, Friess H, Kobrin MS, Büchler MW, Korc M
Int J Cancer. 1995
PubMed ID: 7665222
-
Shb is a ubiquitously expressed Src homology 2 protein.
Welsh M, Mares J, Karlsson T, Lavergne C, Bréant B, Claesson-Welsh L
Oncogene. 1994
PubMed ID: 8302579
Publications: 529
-
Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm.
Chmielecki J, Peifer M, Viale A, Hutchinson K, Giltnane J, Socci ND, Hollis CJ, Dean RS, Yenamandra A, Jagasia M, Kim AS, Davé UP, Thomas RK, Pao W
Genes Chromosomes Cancer. 2012
PubMed ID: 21938754
-
Glyceollins inhibit platelet-derived growth factor-mediated human arterial smooth muscle cell proliferation and migration.
Kim HJ, Cha BY, Choi B, Lim JS, Woo JT, Kim JS
Br J Nutr. 2012
PubMed ID: 21733313
-
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.
Alvarez JI, Dodelet-Devillers A, Kebir H, Ifergan I, Fabre PJ, Terouz S, Sabbagh M, Wosik K, Bourbonnière L, Bernard M, van Horssen J, de Vries HE, Charron F, Prat A
Science. 2011
PubMed ID: 22144466
-
PDGF: the nuts and bolts of signalling toolbox.
Farooqi AA, Waseem S, Riaz AM, Dilawar BA, Mukhtar S, Minhaj S, Waseem MS, Daniel S, Malik BA, Nawaz A, Bhatti S
Tumour Biol. 2011
PubMed ID: 21769672
-
Potentiation of platelet-derived growth factor receptor-β signaling mediated by integrin-associated MFG-E8.
Motegi S, Garfield S, Feng X, Sárdy M, Udey MC
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21868707
-
Clinically relevant biomarkers to select patients for targeted inhibitor therapy after resection of hepatocellular carcinoma.
Patel SH, Kneuertz PJ, Delgado M, Kooby DA, Staley CA, El-Rayes BF, Kauh JS, Sarmiento JM, Hanish S, Cohen C, Farris AB, Maithel SK
Ann Surg Oncol. 2011
PubMed ID: 21590454
-
PDGF-β receptor and PKC have no effect on angiotensin II-induced JAK2 and STAT1 phosphorylation in vascular smooth muscle cells under high glucose condition.
Öztürk OH, Çetin A, Tokay A, Uzuner F, Tanrıöver G, Yeşilkaya A
J Recept Signal Transduct Res. 2011
PubMed ID: 21929289
-
A high-resolution molecular atlas of the fetal mouse lower urogenital tract.
Abler LL, Keil KP, Mehta V, Joshi PS, Schmitz CT, Vezina CM
Dev Dyn. 2011
PubMed ID: 21905163
-
Contrasting prognostic implications of platelet-derived growth factor receptor-β and vascular endothelial growth factor receptor-2 in patients with angiosarcoma.
Yonemori K, Tsuta K, Ando M, Hirakawa A, Hatanaka Y, Matsuno Y, Chuman H, Yamazaki N, Fujiwara Y, Hasegawa T
Ann Surg Oncol. 2011
PubMed ID: 21409488
-
Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression.
Goss AM, Tian Y, Cheng L, Yang J, Zhou D, Cohen ED, Morrisey EE
Dev Biol. 2011
PubMed ID: 21704027
-
Characterization of Pdgfrb-Cre transgenic mice reveals reduction of ROSA26 reporter activity in remodeling arteries.
Cuttler AS, LeClair RJ, Stohn JP, Wang Q, Sorenson CM, Liaw L, Lindner V
Genesis. 2011
PubMed ID: 21557454
-
Platelet-derived growth factor (PDGF)-BB produces NO-mediated relaxation and PDGF receptor β-dependent tonic contraction in murine iliac lymph vessels.
Maejima D, Kawai Y, Ajima K, Ohhashi T
Microcirculation. 2011
PubMed ID: 21535294
-
Msx genes define a population of mural cell precursors required for head blood vessel maturation.
Lopes M, Goupille O, Saint Cloment C, Lallemand Y, Cumano A, Robert B
Development. 2011
PubMed ID: 21693521
-
Association of platelet-derived growth factor receptor β accumulation with increased oxidative stress and cellular injury in sestrin 2 silenced human glioblastoma cells.
Liu SY, Lee YJ, Lee TC
FEBS Lett. 2011
PubMed ID: 21536039
-
Disruption of platelet-derived growth factor-dependent phosphatidylinositol 3-kinase and phospholipase Cγ 1 activity abolishes vascular smooth muscle cell proliferation and migration and attenuates neointima formation in vivo.
Caglayan E, Vantler M, Leppänen O, Gerhardt F, Mustafov L, Ten Freyhaus H, Kappert K, Odenthal M, Zimmermann WH, Tallquist MD, Rosenkranz S
J Am Coll Cardiol. 2011
PubMed ID: 21679854
-
PDGFRβ signaling regulates mural cell plasticity and inhibits fat development.
Olson LE, Soriano P
Dev Cell. 2011
PubMed ID: 21664579
-
Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells.
Koide M, Ikeda K, Akakabe Y, Kitamura Y, Ueyama T, Matoba S, Yamada H, Okigaki M, Matsubara H
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21593423
-
Angiopoietin-1 is essential in mouse vasculature during development and in response to injury.
Jeansson M, Gawlik A, Anderson G, Li C, Kerjaschki D, Henkelman M, Quaggin SE
J Clin Invest. 2011
PubMed ID: 21606590
-
Adaptor protein Lnk binds to PDGF receptor and inhibits PDGF-dependent signaling.
Gueller S, Hehn S, Nowak V, Gery S, Serve H, Brandts CH, Koeffler HP
Exp Hematol. 2011
PubMed ID: 21310211
-
Mesenchymal stem cell migration is regulated by fibronectin through α5β1-integrin-mediated activation of PDGFR-β and potentiation of growth factor signals.
Veevers-Lowe J, Ball SG, Shuttleworth A, Kielty CM
J Cell Sci. 2011
PubMed ID: 21429937
-
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21421844
-
Coexpression of PDGFR-alpha, PDGFR-beta and VEGF as a prognostic factor in patients with hepatocellular carcinoma.
Chen L, Shi Y, Jiang CY, Wei LX, Lv YL, Wang YL, Dai GH
Int J Biol Markers. 2011
PubMed ID: 21574155
-
Redox regulation of ERK1/2 activation induced by sphingosine 1-phosphate in fibroblasts: involvement of NADPH oxidase and platelet-derived growth factor receptor.
Catarzi S, Romagnoli C, Marcucci G, Favilli F, Iantomasi T, Vincenzini MT
Biochim Biophys Acta. 2011
PubMed ID: 21256191
-
Wt1 controls retinoic acid signalling in embryonic epicardium through transcriptional activation of Raldh2.
Guadix JA, Ruiz-Villalba A, Lettice L, Velecela V, Muñoz-Chápuli R, Hastie ND, Pérez-Pomares JM, Martínez-Estrada OM
Development. 2011
PubMed ID: 21343363
-
Serotonin transporter interacts with the PDGFβ receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells.
Ren W, Watts SW, Fanburg BL
Am J Physiol Lung Cell Mol Physiol. 2011
PubMed ID: 21186266
-
Multipotent PDGFRβ-expressing cells in the circulation of stroke patients.
Jung KH, Chu K, Lee ST, Bahn JJ, Jeon D, Kim JH, Kim S, Won CH, Kim M, Lee SK, Roh JK
Neurobiol Dis. 2011
PubMed ID: 21074616
-
Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus.
Nakagawa T, Izumino K, Ishii Y, Oya T, Hamashima T, Jie S, Ishizawa S, Tomoda F, Fujimori T, Nabeshima Y, Inoue H, Sasahara M
Nephrol Dial Transplant. 2011
PubMed ID: 20693161
-
Tyr740 and Tyr751 residues of platelet-derived growth factor beta receptor are responsible for the redox regulation of phosphatase and tensin homolog in the cells stimulated with platelet-derived growth factor.
Kim I, Han SJ, Kim Y, Ahn Y, Chay KO, Lee SR
Redox Rep. 2011
PubMed ID: 21888769
-
E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion.
Glen H, Mason S, Patel H, Macleod K, Brunton VG
BMC Cancer. 2011
PubMed ID: 21781317
-
Cognitive and socio-emotional deficits in platelet-derived growth factor receptor-β gene knockout mice.
Nguyen PT, Nakamura T, Hori E, Urakawa S, Uwano T, Zhao J, Li R, Bac ND, Hamashima T, Ishii Y, Matsushima T, Ono T, Sasahara M, Nishijo H
PLoS One. 2011
PubMed ID: 21437241
-
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
-
PDGFR signaling blockade in marrow stroma impairs lung cancer bone metastasis.
Catena R, Luis-Ravelo D, Antón I, Zandueta C, Salazar-Colocho P, Larzábal L, Calvo A, Lecanda F
Cancer Res. 2011
PubMed ID: 21097719
-
Migration of dorsal aorta mesenchymal stem cells induced by mouse embryonic circulation.
Yan XL, Lan Y, Wang XY, He WY, Yao HY, Chen DB, Xiong JX, Gao J, Li Z, Yang G, Li XS, Liu YL, Zhang JY, Liu B, Mao N
Dev Dyn. 2011
PubMed ID: 21089075
-
A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer.
Ustach CV, Huang W, Conley-LaComb MK, Lin CY, Che M, Abrams J, Kim HR
Cancer Res. 2010
PubMed ID: 21098708
-
Expression of platelet-derived growth factor ligand and receptor in cerebral arteriovenous and cavernous malformations.
Yildirim O, Bicer A, Ozkan A, Kurtkaya O, Cirakoglu B, Kilic T
J Clin Neurosci. 2010
PubMed ID: 20822908
-
Polymorphisms in TGFB1 and PDGFRB are associated with Moyamoya disease in European patients.
Roder C, Peters V, Kasuya H, Nishizawa T, Takehara Y, Berg D, Schulte C, Khan N, Tatagiba M, Krischek B
Acta Neurochir (Wien). 2010
PubMed ID: 20571834
-
Pericytes are required for blood-brain barrier integrity during embryogenesis.
Daneman R, Zhou L, Kebede AA, Barres BA
Nature. 2010
PubMed ID: 20944625
-
Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124.
Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, Kuo CJ
Science. 2010
PubMed ID: 21071672
-
Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging.
Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV
Neuron. 2010
PubMed ID: 21040844
-
The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress.
Kim TS, Kawaguchi M, Suzuki M, Jung CG, Asai K, Shibamoto Y, Lavin MF, Khanna KK, Miura Y
Dis Model Mech. 2010
PubMed ID: 20876357
-
Protein tyrosine phosphatase PTPepsilonM negatively regulates PDGF beta-receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells.
Shimizu H, Nakagawa Y, Murakami C, Aoki N, Kim-Mitsuyama S, Miyazaki H
Am J Physiol Cell Physiol. 2010
PubMed ID: 20686073
-
Weak association of the platelet-derived growth factor beta (PDGFB) and PDGF receptor beta (PDGFRB) genes with schizophrenia and schizoaffective disorder.
Zai G, Zai C, Tiwari A, King N, Braithwaite J, van Tol H, Kennedy JL
World J Biol Psychiatry. 2010
PubMed ID: 20950212
-
Enlarged lateral ventricles and aberrant behavior in mice overexpressing PDGF-B in embryonic neural stem cells.
Niklasson M, Bergström T, Zhang XQ, Gustafsdottir SM, Sjögren M, Edqvist PH, Vennström B, Forsberg M, Forsberg-Nilsson K
Exp Cell Res. 2010
PubMed ID: 20643125
-
Dysfunctional, pro-inflammatory HDL directly upregulates monocyte PDGFRβ, chemotaxis and TNFα production.
Skaggs BJ, Hahn BH, Sahakian L, Grossman J, McMahon M
Clin Immunol. 2010
PubMed ID: 20637704
-
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
-
Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor β is associated with lymphatic metastasis in human gastric carcinoma.
Kodama M, Kitadai Y, Sumida T, Ohnishi M, Ohara E, Tanaka M, Shinagawa K, Tanaka S, Yasui W, Chayama K
Cancer Sci. 2010
PubMed ID: 20624165
-
Transcription factor CHF1/Hey2 regulates coronary vascular maturation.
Watanabe T, Koibuchi N, Chin MT
Mech Dev. 2010
PubMed ID: 20619341
-
PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL.
Getachew R, Ballinger ML, Burch ML, Reid JJ, Khachigian LM, Wight TN, Little PJ, Osman N
Endocrinology. 2010
PubMed ID: 20610572
-
Temporal and spatial resolution of type I and III interferon responses in vivo.
Pulverer JE, Rand U, Lienenklaus S, Kugel D, Zietara N, Kochs G, Naumann R, Weiss S, Staeheli P, Hauser H, Köster M
J Virol. 2010
PubMed ID: 20573823
-
Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration.
Wardega P, Heldin CH, Lennartsson J
Cell Signal. 2010
PubMed ID: 20494825
-
Contribution of CXCR4(+)/PDGFRbeta(+) progenitor cells in hypoxic alveolar arterioles muscularization: role of myocardin.
Jie W, Wang X, Huang L, Guo J, Kuang D, Zhu P, Li M, Zhao X, Duan Y, Wang G, Ao Q
Cardiovasc Res. 2010
PubMed ID: 20484220
-
Dimerization drives PDGF receptor endocytosis through a C-terminal hydrophobic motif shared by EGF receptor.
Pahara J, Shi H, Chen X, Wang Z
Exp Cell Res. 2010
PubMed ID: 20580638
-
Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways.
Mendelson K, Swendeman S, Saftig P, Blobel CP
J Biol Chem. 2010
PubMed ID: 20529858
-
Differential involvement of caveolin-1 in brown adipocyte signaling: impaired beta3-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling.
Mattsson CL, Andersson ER, Nedergaard J
Biochim Biophys Acta. 2010
PubMed ID: 20381543
-
Role of growth factor receptor transactivation in high glucose-induced increased levels of Gq/11alpha and signaling in vascular smooth muscle cells.
Descorbeth M, Anand-Srivastava MB
J Mol Cell Cardiol. 2010
PubMed ID: 20036247
-
Elucidating mechanisms of osteogenesis in human adipose-derived stromal cells via microarray analysis.
Lee J, Gupta D, Panetta NJ, Levi B, James AW, Wan D, Commons GW, Longaker MT
J Craniofac Surg. 2010
PubMed ID: 20613589
-
N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathy.
Lei H, Velez G, Cui J, Samad A, Maberley D, Matsubara J, Kazlauskas A
Am J Pathol. 2010
PubMed ID: 20489144
-
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
-
The transcriptional repression of platelet-derived growth factor receptor-beta by the zinc finger transcription factor ZNF24.
Li J, Chen X, Liu Y, Ding L, Qiu L, Hu Z, Zhang J
Biochem Biophys Res Commun. 2010
PubMed ID: 20510677
-
Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.
Shim AH, Liu H, Focia PJ, Chen X, Lin PC, He X
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20534510
-
Molecular cloning of the human platelet-derived growth factor receptor beta (PDGFR-beta) promoter and drug targeting of the G-quadruplex-forming region to repress PDGFR-beta expression.
Qin Y, Fortin JS, Tye D, Gleason-Guzman M, Brooks TA, Hurley LH
Biochemistry. 2010
PubMed ID: 20377208
-
Screening for diverse PDGFRA or PDGFRB fusion genes is facilitated by generic quantitative reverse transcriptase polymerase chain reaction analysis.
Erben P, Gosenca D, Müller MC, Reinhard J, Score J, Del Valle F, Walz C, Mix J, Metzgeroth G, Ernst T, Haferlach C, Cross NC, Hochhaus A, Reiter A
Haematologica. 2010
PubMed ID: 20107158
-
Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved.
Zheng L, Ishii Y, Tokunaga A, Hamashima T, Shen J, Zhao QL, Ishizawa S, Fujimori T, Nabeshima Y, Mori H, Kondo T, Sasahara M
J Neurosci Res. 2010
PubMed ID: 19998489
-
Critical role of the platelet-derived growth factor receptor (PDGFR) beta transmembrane domain in the TEL-PDGFRbeta cytosolic oncoprotein.
Toffalini F, Hellberg C, Demoulin JB
J Biol Chem. 2010
PubMed ID: 20164181
-
Immunohistochemical detection of receptor tyrosine kinases c-kit, EGF-R, and PDGF-R in colorectal adenocarcinomas.
Friederichs J, von Weyhern CW, Rosenberg R, Doll D, Busch R, Lordick F, Siewert JR, Sarbia M
Langenbecks Arch Surg. 2010
PubMed ID: 19280218
-
Epicardial-myocardial signaling directing coronary vasculogenesis.
Olivey HE, Svensson EC
Circ Res. 2010
PubMed ID: 20299672
-
ABT-869 inhibits the proliferation of Ewing Sarcoma cells and suppresses platelet-derived growth factor receptor beta and c-KIT signaling pathways.
Ikeda AK, Judelson DR, Federman N, Glaser KB, Landaw EM, Denny CT, Sakamoto KM
Mol Cancer Ther. 2010
PubMed ID: 20197394
-
Strong oligomerization behavior of PDGFbeta receptor transmembrane domain and its regulation by the juxtamembrane regions.
Oates J, King G, Dixon AM
Biochim Biophys Acta. 2010
PubMed ID: 20036637
-
Platelet-derived growth factor receptor signaling is not involved in osteogenic differentiation of human mesenchymal stem cells.
Kumar A, Salimath BP, Stark GB, Finkenzeller G
Tissue Eng Part A. 2010
PubMed ID: 19839721
-
Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma.
Huang D, Ding Y, Li Y, Luo WM, Zhang ZF, Snider J, Vandenbeldt K, Qian CN, Teh BT
Cancer Res. 2010
PubMed ID: 20103629
-
Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress.
Chintalgattu V, Ai D, Langley RR, Zhang J, Bankson JA, Shih TL, Reddy AK, Coombes KR, Daher IN, Pati S, Patel SS, Pocius JS, Taffet GE, Buja LM, Entman ML, Khakoo AY
J Clin Invest. 2010
PubMed ID: 20071776
-
Endothelial progenitor cells induce a phenotype shift in differentiated endothelial cells towards PDGF/PDGFRβ axis-mediated angiogenesis.
Wyler von Ballmoos M, Yang Z, Völzmann J, Baumgartner I, Kalka C, Di Santo S
PLoS One. 2010
PubMed ID: 21124835
-
Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-β phosphorylation, and microvessel density in gastric cancer.
Suzuki S, Dobashi Y, Hatakeyama Y, Tajiri R, Fujimura T, Heldin CH, Ooi A
BMC Cancer. 2010
PubMed ID: 21118571
-
Transactivation of PDGFRbeta by dopamine D4 receptor does not require PDGFRbeta dimerization.
Chi SS, Vetiska SM, Gill RS, Hsiung MS, Liu F, Van Tol HH
Mol Brain. 2010
PubMed ID: 20659339
-
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer)
PLoS Genet. 2010
PubMed ID: 20628624
-
Stromal PDGFRbeta expression in prostate tumors and non-malignant prostate tissue predicts prostate cancer survival.
Hägglöf C, Hammarsten P, Josefsson A, Stattin P, Paulsson J, Bergh A, Ostman A
PLoS One. 2010
PubMed ID: 20505768
-
L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, Niu T, Hosoya T
Nephron Clin Pract. 2010
PubMed ID: 20424473
-
Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development.
He Y, Zhang H, Yu L, Gunel M, Boggon TJ, Chen H, Min W
Sci Signal. 2010
PubMed ID: 20371769
-
Foxn1 is essential for vascularization of the murine thymus anlage.
Mori K, Itoi M, Tsukamoto N, Amagai T
Cell Immunol. 2010
PubMed ID: 19853842
-
An automated and multiplexed method for high throughput peptide immunoaffinity enrichment and multiple reaction monitoring mass spectrometry-based quantification of protein biomarkers.
Whiteaker JR, Zhao L, Anderson L, Paulovich AG
Mol Cell Proteomics. 2010
PubMed ID: 19843560
-
Dysregulation of platelet-derived growth factor beta-receptor expression by DeltaNp73 in neuroblastoma.
Wetterskog D, Moshiri A, Ozaki T, Uramoto H, Nakagawara A, Funa K
Mol Cancer Res. 2009
PubMed ID: 19952113
-
Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.
Guignabert C, Alvira CM, Alastalo TP, Sawada H, Hansmann G, Zhao M, Wang L, El-Bizri N, Rabinovitch M
Am J Physiol Lung Cell Mol Physiol. 2009
PubMed ID: 19801450
-
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
-
Shortening of human cell life span by induction of p16ink4a through the platelet-derived growth factor receptor beta.
Takahashi H, Toyoda M, Birumachi J, Horie A, Uyama T, Miyado K, Matsumoto K, Saito H, Umezawa A
J Cell Physiol. 2009
PubMed ID: 19582773
-
Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination.
Guo X, Nie L, Esmailzadeh L, Zhang J, Bender JR, Sadeghi MM
J Biol Chem. 2009
PubMed ID: 19696027
-
Platelet-derived growth factor receptor expression and activation in choroid plexus tumors.
Koos B, Paulsson J, Jarvius M, Sanchez BC, Wrede B, Mertsch S, Jeibmann A, Kruse A, Peters O, Wolff JE, Galla HJ, Söderberg O, Paulus W, Ostman A, Hasselblatt M
Am J Pathol. 2009
PubMed ID: 19717644
-
Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling.
Zeini M, Hang CT, Lehrer-Graiwer J, Dao T, Zhou B, Chang CP
Development. 2009
PubMed ID: 19710169
-
Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-beta.
Fuhrman B, Gantman A, Khateeb J, Volkova N, Horke S, Kiyan J, Dumler I, Aviram M
Cardiovasc Res. 2009
PubMed ID: 19497963
-
Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway.
Cohen ED, Ihida-Stansbury K, Lu MM, Panettieri RA, Jones PL, Morrisey EE
J Clin Invest. 2009
PubMed ID: 19690384
-
Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors.
Eskens FA, Steeghs N, Verweij J, Bloem JL, Christensen O, van Doorn L, Ouwerkerk J, de Jonge MJ, Nortier JW, Kraetzschmar J, Rajagopalan P, Gelderblom H
J Clin Oncol. 2009
PubMed ID: 19636022
-
VEGFR2+PDGFRbeta+ circulating precursor cells participate in capillary restoration after hyperoxia acute lung injury (HALI).
Jones R, Capen DE, Jacobson M, Cohen KS, Scadden DT, Duda DG
J Cell Mol Med. 2009
PubMed ID: 19426150
-
Krüppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor beta-mediated, not by retinoic acid receptor alpha-mediated, phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cells.
Zheng B, Han M, Bernier M, Zhang XH, Meng F, Miao SB, He M, Zhao XM, Wen JK
J Biol Chem. 2009
PubMed ID: 19531492
-
The fusion proteins TEL-PDGFRbeta and FIP1L1-PDGFRalpha escape ubiquitination and degradation.
Toffalini F, Kallin A, Vandenberghe P, Pierre P, Michaux L, Cools J, Demoulin JB
Haematologica. 2009
PubMed ID: 19644140
-
Cell migration is regulated by platelet-derived growth factor receptor endocytosis.
Kawada K, Upadhyay G, Ferandon S, Janarthanan S, Hall M, Vilardaga JP, Yajnik V
Mol Cell Biol. 2009
PubMed ID: 19528233
-
ROS and PDGF-beta [corrected] receptors are critically involved in indoxyl sulfate actions that promote vascular smooth muscle cell proliferation and migration.
Shimizu H, Hirose Y, Nishijima F, Tsubakihara Y, Miyazaki H
Am J Physiol Cell Physiol. 2009
PubMed ID: 19494236
-
The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature.
Takabatake Y, Sugiyama T, Kohara H, Matsusaka T, Kurihara H, Koni PA, Nagasawa Y, Hamano T, Matsui I, Kawada N, Imai E, Nagasawa T, Rakugi H, Isaka Y
J Am Soc Nephrol. 2009
PubMed ID: 19443644
-
Effects of lipopolysaccharide on platelet-derived growth factor isoform and receptor expression in cultured rat common bile duct fibroblasts and cholangiocytes.
Kim TH, Moon JH, Savard CE, Kuver R, Lee SP
J Gastroenterol Hepatol. 2009
PubMed ID: 19691150
-
Hypoxic ventilatory response in platelet-derived growth factor receptor-beta-knockout mice.
Tsunekawa S, Ohi Y, Ishii Y, Sasahara M, Haji A
J Pharmacol Sci. 2009
PubMed ID: 19542682
-
A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles.
Pollizzi K, Malinowska-Kolodziej I, Doughty C, Betz C, Ma J, Goto J, Kwiatkowski DJ
Hum Mol Genet. 2009
PubMed ID: 19357198
-
Regulation of platelet-derived growth factor receptor function by integrin-associated cell surface transglutaminase.
Zemskov EA, Loukinova E, Mikhailenko I, Coleman RA, Strickland DK, Belkin AM
J Biol Chem. 2009
PubMed ID: 19386600
-
Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development.
Freeman-Anderson NE, Zheng Y, McCalla-Martin AC, Treanor LM, Zhao YD, Garfin PM, He TC, Mary MN, Thornton JD, Anderson C, Gibbons M, Saab R, Baumer SH, Cunningham JM, Skapek SX
Development. 2009
PubMed ID: 19465598
-
CSF1R copy number changes, point mutations, and RNA and protein overexpression in renal cell carcinomas.
Soares MJ, Pinto M, Henrique R, Vieira J, Cerveira N, Peixoto A, Martins AT, Oliveira J, Jerónimo C, Teixeira MR
Mod Pathol. 2009
PubMed ID: 19377443
-
Activation of protein kinase C alpha is necessary for sorting the PDGF beta-receptor to Rab4a-dependent recycling.
Hellberg C, Schmees C, Karlsson S, Ahgren A, Heldin CH
Mol Biol Cell. 2009
PubMed ID: 19369415
-
Transactivation of RON receptor tyrosine kinase by interaction with PDGF receptor beta during steady-state growth of human mesangial cells.
Kobayashi T, Furukawa Y, Kikuchi J, Ito C, Miyata Y, Muto S, Tanaka A, Kusano E
Kidney Int. 2009
PubMed ID: 19242504
-
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
-
Potential roles of growth factor PDGF-BB in the bony repair of injured growth plate.
Chung R, Foster BK, Zannettino AC, Xian CJ
Bone. 2009
PubMed ID: 19442606
-
Imatinib inhibits in vitro proliferation of cells derived from a pleural solitary fibrous tumor expressing platelet-derived growth factor receptor-beta.
Prunotto M, Bosco M, Daniele L, Macri' L, Bonello L, Schirosi L, Rossi G, Filosso P, Mussa B, Sapino A
Lung Cancer. 2009
PubMed ID: 19041155
-
Transient expression of the Arf tumor suppressor during male germ cell and eye development in Arf-Cre reporter mice.
Gromley A, Churchman ML, Zindy F, Sherr CJ
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19339492
-
Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis.
Classen JF, Henrohn D, Rorsman F, Lennartsson J, Lauwerys BR, Wikström G, Rorsman C, Lenglez S, Franck-Larsson K, Tomasi JP, Kämpe O, Vanthuyne M, Houssiau FA, Demoulin JB
Arthritis Rheum. 2009
PubMed ID: 19333949
-
Expression and molecular analysis of c-kit and PDGFRs in Kaposi's sarcoma of different stages and epidemiological settings.
Rossi G, Sartori G, Rusev BC, Sgambato A
Histopathology. 2009
PubMed ID: 19302534
-
Combined anti-PDGFRalpha and PDGFRbeta targeting in non-small cell lung cancer.
Reinmuth N, Liersch R, Raedel M, Fehrmann F, Fehrmann N, Bayer M, Schwoeppe C, Kessler T, Berdel W, Thomas M, Mesters RM
Int J Cancer. 2009
PubMed ID: 19115205
-
Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons.
Beazely MA, Lim A, Li H, Trepanier C, Chen X, Sidhu B, Macdonald JF
J Biol Chem. 2009
PubMed ID: 19106110
-
Reciprocal regulation of the platelet-derived growth factor receptor-beta and G protein-coupled receptor kinase 5 by cross-phosphorylation: effects on catalysis.
Cai X, Wu JH, Exum ST, Oppermann M, Premont RT, Shenoy SK, Freedman NJ
Mol Pharmacol. 2009
PubMed ID: 19092051
-
Differential effects of red and white wines on inhibition of the platelet-derived growth factor receptor: impact of the mash fermentation.
Sparwel J, Vantler M, Caglayan E, Kappert K, Fries JW, Dietrich H, Böhm M, Erdmann E, Rosenkranz S
Cardiovasc Res. 2009
PubMed ID: 19074160
-
Molecular framework for response to imatinib mesylate in systemic sclerosis.
Chung L, Fiorentino DF, Benbarak MJ, Adler AS, Mariano MM, Paniagua RT, Milano A, Connolly MK, Ratiner BD, Wiskocil RL, Whitfield ML, Chang HY, Robinson WH
Arthritis Rheum. 2009
PubMed ID: 19180499
-
PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA.
Ricono JM, Wagner B, Gorin Y, Arar M, Kazlauskas A, Choudhury GG, Abboud HE
Am J Physiol Renal Physiol. 2009
PubMed ID: 19019919
-
Identification of a MYO18A-PDGFRB fusion gene in an eosinophilia-associated atypical myeloproliferative neoplasm with a t(5;17)(q33-34;q11.2).
Walz C, Haferlach C, Hänel A, Metzgeroth G, Erben P, Gosenca D, Hochhaus A, Cross NC, Reiter A
Genes Chromosomes Cancer. 2009
PubMed ID: 19006078
-
Gene transfer of redox factor-1 inhibits neointimal formation: involvement of platelet-derived growth factor-beta receptor signaling via the inhibition of the reactive oxygen species-mediated Syk pathway.
Lee HM, Jeon BH, Won KJ, Lee CK, Park TK, Choi WS, Bae YM, Kim HS, Lee SK, Park SH, Irani K, Kim B
Circ Res. 2009
PubMed ID: 19038866
-
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
Cell. 2009
PubMed ID: 19167335
-
Combination of imatinib and vinorelbine enhances cell growth inhibition in breast cancer cells via PDGFR beta signalling.
Weigel MT, Meinhold-Heerlein I, Bauerschlag DO, Schem C, Bauer M, Jonat W, Maass N, Mundhenke C
Cancer Lett. 2009
PubMed ID: 18809244
-
LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation.
Zhou L, Takayama Y, Boucher P, Tallquist MD, Herz J
PLoS One. 2009
PubMed ID: 19742316
-
MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing.
Lehti K, Rose NF, Valavaara S, Weiss SJ, Keski-Oja J
J Cell Sci. 2009
PubMed ID: 19066283
-
PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway.
Brown MV, Burnett PE, Denning MF, Reynolds AB
Exp Cell Res. 2009
PubMed ID: 18950621
-
Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Enjuanes A, Benavente Y, Bosch F, Martín-Guerrero I, Colomer D, Pérez-Alvarez S, Reina O, Ardanaz MT, Jares P, García-Orad A, Pujana MA, Montserrat E, de Sanjosé S, Campo E
Cancer Res. 2008
PubMed ID: 19074885
-
Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations.
Mellgren AM, Smith CL, Olsen GS, Eskiocak B, Zhou B, Kazi MN, Ruiz FR, Pu WT, Tallquist MD
Circ Res. 2008
PubMed ID: 18948621
-
The PDGF signaling pathway controls multiple steroid-producing lineages.
Schmahl J, Rizzolo K, Soriano P
Genes Dev. 2008
PubMed ID: 19056881
-
mRNA expression of platelet-derived growth factor receptor-beta and C-KIT: correlation with pathologic response to cetuximab-based chemoradiotherapy in patients with rectal cancer.
Erben P, Horisberger K, Muessle B, Müller MC, Treschl A, Ernst T, Kähler G, Ströbel P, Wenz F, Kienle P, Post S, Hochhaus A, Willeke F, Hofheinz RD
Int J Radiat Oncol Biol Phys. 2008
PubMed ID: 19028276
-
Platelet-derived growth factor receptor beta-subtype regulates proliferation and migration of gonocytes.
Basciani S, De Luca G, Dolci S, Brama M, Arizzi M, Mariani S, Rosano G, Spera G, Gnessi L
Endocrinology. 2008
PubMed ID: 18687785
-
Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature.
Stenman JM, Rajagopal J, Carroll TJ, Ishibashi M, McMahon J, McMahon AP
Science. 2008
PubMed ID: 19023080
-
The dietary flavones apigenin and luteolin impair smooth muscle cell migration and VEGF expression through inhibition of PDGFR-beta phosphorylation.
Lamy S, Bédard V, Labbé D, Sartelet H, Barthomeuf C, Gingras D, Béliveau R
Cancer Prev Res (Phila Pa). 2008
PubMed ID: 19138992
-
Involvement of platelet-derived growth factor receptor-beta in maintenance of mesenchyme and sensory epithelium of the neonatal mouse inner ear.
Hayashi H, Kunisada T, Takakura N, Aoki M, Mizuta K, Ito Y
Hear Res. 2008
PubMed ID: 18817860
-
A gain-of-function mutation in the PDGFR-beta alters the kinetics of injury response in liver and skin.
Krampert M, Heldin CH, Heuchel RL
Lab Invest. 2008
PubMed ID: 18762776
-
Kinetics of repression by modified p53 on the PDGF beta-receptor promoter.
Yang W, Wetterskog D, Matsumoto Y, Funa K
Int J Cancer. 2008
PubMed ID: 18697203
-
Molecular analysis of PDGFRA and PDGFRB genes by rapid single-strand conformation polymorphism (SSCP) in patients with core-binding factor leukaemias with KIT or FLT3 mutation.
Trojani A, Ripamonti CB, Penco S, Beghini A, Nadali G, Di Bona E, Viola A, Castagnola C, Colapietro P, Grillo G, Pezzetti L, Ravelli E, Patrosso MC, Marocchi A, Cuneo A, Ferrara F, Lazzarino M, Pizzolo G, Cairoli R, Morra E
Anticancer Res. 2008
PubMed ID: 19035305
-
Serum response factor is required for sprouting angiogenesis and vascular integrity.
Franco CA, Mericskay M, Parlakian A, Gary-Bobo G, Gao-Li J, Paulin D, Gustafsson E, Li Z
Dev Cell. 2008
PubMed ID: 18804439
-
C-reactive protein and vein graft disease: evidence for a direct effect on smooth muscle cell phenotype via modulation of PDGF receptor-beta.
Ho KJ, Owens CD, Longo T, Sui XX, Ifantides C, Conte MS
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 18621860
-
Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function.
French WJ, Creemers EE, Tallquist MD
Mol Cell Biol. 2008
PubMed ID: 18606782
-
Expression of c-kit and platelet-derived growth factor receptors in ovarian granulosa cell tumors.
Rocconi RP, Matthews KS, Kimball KJ, Conner MG, Baker AC, Barnes MN
Reprod Sci. 2008
PubMed ID: 18492696
-
PDGF receptor beta is a potent regulator of mesenchymal stromal cell function.
Tokunaga A, Oya T, Ishii Y, Motomura H, Nakamura C, Ishizawa S, Fujimori T, Nabeshima Y, Umezawa A, Kanamori M, Kimura T, Sasahara M
J Bone Miner Res. 2008
PubMed ID: 18410236
-
Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells.
Lucero HA, Ravid K, Grimsby JL, Rich CB, DiCamillo SJ, Mäki JM, Myllyharju J, Kagan HM
J Biol Chem. 2008
PubMed ID: 18586678
-
Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression.
Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, Suzuki H, Aizawa S, Arakaki M, Yuasa K, Oka K, Chai Y, Nonaka K, Fukumoto S
J Biol Chem. 2008
PubMed ID: 18559345
-
Validation of PDGFRbeta and c-Src tyrosine kinases as tumor/vessel targets in patients with multiple myeloma: preclinical efficacy of the novel, orally available inhibitor dasatinib.
Coluccia AM, Cirulli T, Neri P, Mangieri D, Colanardi MC, Gnoni A, Di Renzo N, Dammacco F, Tassone P, Ribatti D, Gambacorti-Passerini C, Vacca A
Blood. 2008
PubMed ID: 18524994
-
Msx1 and Msx2 are expressed in sub-populations of vascular smooth muscle cells.
Goupille O, Saint Cloment C, Lopes M, Montarras D, Robert B
Dev Dyn. 2008
PubMed ID: 18627106
-
Genetic association between 5'-upstream single-nucleotide polymorphisms of PDGFRB and schizophrenia in a Korean population.
Kim HJ, Kim MH, Choe BK, Kim JW, Park JK, Cho AR, Bae H, Shin DH, Yim SV, Kwack K, Kwon YK, Chung JH
Schizophr Res. 2008
PubMed ID: 18541413
-
PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells.
Biswas SK, Zhao Y, Nagalingam A, Gardner TW, Sandirasegarane L
Invest Ophthalmol Vis Sci. 2008
PubMed ID: 18421086
-
Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesis.
Kuhnert F, Tam BY, Sennino B, Gray JT, Yuan J, Jocson A, Nayak NR, Mulligan RC, McDonald DM, Kuo CJ
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18632559
-
A myocardial lineage derives from Tbx18 epicardial cells.
Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM
Nature. 2008
PubMed ID: 18480752
-
Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.
Jin P, Zhang J, Sumariwalla PF, Ni I, Jorgensen B, Crawford D, Phillips S, Feldmann M, Shepard HM, Paleolog EM
Arthritis Res Ther. 2008
PubMed ID: 18593464
-
LKB1 in endothelial cells is required for angiogenesis and TGF{beta}-mediated vascular smooth muscle cell recruitment.
Londesborough A, Vaahtomeri K, Tiainen M, Katajisto P, Ekman N, Vallenius T, Mäkelä TP
Development. 2008
PubMed ID: 18539926
-
Platelet-derived growth factor may be associated with fibrosis in a Down syndrome patient with transient myeloproliferative disorder.
Ogawa J, Kanegane H, Tsuneyama K, Kanezaki R, Futatani T, Nomura K, Ishizawa S, Sasahara M, Ito E, Miyawaki T
Eur J Haematol. 2008
PubMed ID: 18331602
-
Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells.
Jin S, Hansson EM, Tikka S, Lanner F, Sahlgren C, Farnebo F, Baumann M, Kalimo H, Lendahl U
Circ Res. 2008
PubMed ID: 18483410
-
Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas.
Thorarinsdottir HK, Santi M, McCarter R, Rushing EJ, Cornelison R, Jales A, MacDonald TJ
Clin Cancer Res. 2008
PubMed ID: 18519768
-
Role of platelet-derived growth factors in physiology and medicine.
Andrae J, Gallini R, Betsholtz C
Genes Dev. 2008
PubMed ID: 18483217
-
Platelet-derived growth factor signals play critical roles in differentiation of longitudinal smooth muscle cells in mouse embryonic gut.
Kurahashi M, Niwa Y, Cheng J, Ohsaki Y, Fujita A, Goto H, Fujimoto T, Torihashi S
Neurogastroenterol Motil. 2008
PubMed ID: 18194151
-
Platelet-derived growth factors (PDGF-A and -B) and their receptors in human fetal and adult ovaries.
Pinkas H, Fisch B, Rozansky G, Felz C, Kessler-Icekson G, Krissi H, Nitke S, Ao A, Abir R
Mol Hum Reprod. 2008
PubMed ID: 18326546
-
Effects of osmotic stress on the activity of MAPKs and PDGFR-beta-mediated signal transduction in NIH-3T3 fibroblasts.
Nielsen MB, Christensen ST, Hoffmann EK
Am J Physiol Cell Physiol. 2008
PubMed ID: 18272822
-
Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein.
Hook VY, Kindy M, Hook G
J Biol Chem. 2008
PubMed ID: 18184658
-
RNA interference screen identifies Abl kinase and PDGFR signaling in Chlamydia trachomatis entry.
Elwell CA, Ceesay A, Kim JH, Kalman D, Engel JN
PLoS Pathog. 2008
PubMed ID: 18369471
-
Interaction and localization of Necl-5 and PDGF receptor beta at the leading edges of moving NIH3T3 cells: Implications for directional cell movement.
Amano H, Ikeda W, Kawano S, Kajita M, Tamaru Y, Inoue N, Minami Y, Yamada A, Takai Y
Genes Cells. 2008
PubMed ID: 18298801
-
PDGF-A as an epicardial mitogen during heart development.
Kang J, Gu Y, Li P, Johnson BL, Sucov HM, Thomas PS
Dev Dyn. 2008
PubMed ID: 18297729
-
PDGFRalpha/beta expression correlates with the metastatic behavior of human colorectal cancer: a possible rationale for a molecular targeting strategy.
Wehler TC, Frerichs K, Graf C, Drescher D, Schimanski K, Biesterfeld S, Berger MR, Kanzler S, Junginger T, Galle PR, Moehler M, Gockel I, Schimanski CC
Oncol Rep. 2008
PubMed ID: 18288404
-
Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice.
Ishii Y, Matsumoto Y, Watanabe R, Elmi M, Fujimori T, Nissen J, Cao Y, Nabeshima Y, Sasahara M, Funa K
Mol Cell Neurosci. 2008
PubMed ID: 18243733
-
Cyclic strain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGF receptor beta.
Shimizu N, Yamamoto K, Obi S, Kumagaya S, Masumura T, Shimano Y, Naruse K, Yamashita JK, Igarashi T, Ando J
J Appl Physiol. 2008
PubMed ID: 18187612
-
Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas.
Nupponen NN, Paulsson J, Jeibmann A, Wrede B, Tanner M, Wolff JE, Paulus W, Ostman A, Hasselblatt M
Mod Pathol. 2008
PubMed ID: 18157090
-
Crosstalk between angiotensin II and platelet derived growth factor-BB mediated signal pathways in cardiomyocytes.
Wang C, Wu LL, Liu J, Zhang ZG, Fan D, Li L
Chin Med J (Engl). 2008
PubMed ID: 18298916
-
Fusion of PRKG2 and SPTBN1 to the platelet-derived growth factor receptor beta gene (PDGFRB) in imatinib-responsive atypical myeloproliferative disorders.
Gallagher G, Horsman DE, Tsang P, Forrest DL
Cancer Genet Cytogenet. 2008
PubMed ID: 18262053
-
PDGF-B signaling is important for murine cardiac development: its role in developing atrioventricular valves, coronaries, and cardiac innervation.
Van den Akker NM, Winkel LC, Nisancioglu MH, Maas S, Wisse LJ, Armulik A, Poelmann RE, Lie-Venema H, Betsholtz C, Gittenberger-de Groot AC
Dev Dyn. 2008
PubMed ID: 18213589
-
Pulmonary hypoplasia in the connective tissue growth factor (Ctgf) null mouse.
Baguma-Nibasheka M, Kablar B
Dev Dyn. 2008
PubMed ID: 18213577
-
Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring.
Mori R, Shaw TJ, Martin P
J Exp Med. 2008
PubMed ID: 18180311
-
Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli.
Benedito R, Trindade A, Hirashima M, Henrique D, da Costa LL, Rossant J, Gill PS, Duarte A
BMC Dev Biol. 2008
PubMed ID: 19087347
-
Abelson tyrosine kinase links PDGFbeta receptor activation to cytoskeletal regulation of NMDA receptors in CA1 hippocampal neurons.
Beazely MA, Weerapura M, MacDonald JF
Mol Brain. 2008
PubMed ID: 19077273
-
Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells.
Wu E, Palmer N, Tian Z, Moseman AP, Galdzicki M, Wang X, Berger B, Zhang H, Kohane IS
PLoS One. 2008
PubMed ID: 19030102
-
Altered migration and adhesion potential of pro-neurally converted human bone marrow stromal cells.
Habisch HJ, Fiedler J, Ludolph AC, Storch A, Brenner RE
Cytotherapy. 2008
PubMed ID: 19016370
-
A new look at platelet-derived growth factor in renal disease.
Floege J, Eitner F, Alpers CE
J Am Soc Nephrol. 2008
PubMed ID: 18077793
-
TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC.
Siegbahn A, Johnell M, Nordin A, Aberg M, Velling T
Arterioscler Thromb Vasc Biol. 2008
PubMed ID: 17991872
-
Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2: implications for cellular morphology.
Nakata S, Fujita N, Kitagawa Y, Okamoto R, Ogita H, Takai Y
J Biol Chem. 2007
PubMed ID: 17971444
-
Distinct roles and regulations for HoxD genes in metanephric kidney development.
Di-Poï N, Zákány J, Duboule D
PLoS Genet. 2007
PubMed ID: 18159948
-
Saireito probably prevents mesangial cell proliferation in HIGA mice via PDGF-BB tyrosine kinase inhibition.
Hattori T, Sadakane C, Koseki J, Kase Y, Takeda S
Clin Exp Nephrol. 2007
PubMed ID: 18085387
-
RhoB regulates PDGFR-beta trafficking and signaling in vascular smooth muscle cells.
Huang M, Duhadaway JB, Prendergast GC, Laury-Kleintop LD
Arterioscler Thromb Vasc Biol. 2007
PubMed ID: 17951322
-
Dual targeting of IGF-1R and PDGFR inhibits proliferation in high-grade gliomas cells and induces radiosensitivity in JNK-1 expressing cells.
Carapancea M, Cosaceanu D, Budiu R, Kwiecinska A, Tataranu L, Ciubotaru V, Alexandru O, Banita M, Pisoschi C, Bäcklund ML, Lewensohn R, Dricu A
J Neurooncol. 2007
PubMed ID: 17568996
-
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.
Fischer C, Jonckx B, Mazzone M, Zacchigna S, Loges S, Pattarini L, Chorianopoulos E, Liesenborghs L, Koch M, De Mol M, Autiero M, Wyns S, Plaisance S, Moons L, van Rooijen N, Giacca M, Stassen JM, Dewerchin M, Collen D, Carmeliet P
Cell. 2007
PubMed ID: 17981115
-
Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells from human endometrium.
Schwab KE, Gargett CE
Hum Reprod. 2007
PubMed ID: 17872908
-
A stroma targeted therapy enhances castration effects in a transplantable rat prostate cancer model.
Johansson A, Jones J, Pietras K, Kilter S, Skytt A, Rudolfsson SH, Bergh A
Prostate. 2007
PubMed ID: 17854058
-
Chlamydia pneumoniae infection of aortic smooth muscle cells reduces platelet-derived growth factor receptor-beta expression.
Rödel J, Lehmann M, Vogelsang H, Straube E
FEMS Immunol Med Microbiol. 2007
PubMed ID: 17727656
-
Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.
Reddi AL, Ying G, Duan L, Chen G, Dimri M, Douillard P, Druker BJ, Naramura M, Band V, Band H
J Biol Chem. 2007
PubMed ID: 17620338
-
Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro.
Magnusson PU, Looman C, Ahgren A, Wu Y, Claesson-Welsh L, Heuchel RL
Arterioscler Thromb Vasc Biol. 2007
PubMed ID: 17656670
-
Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-beta: implications for diabetic atherosclerosis.
Cantero AV, Portero-Otín M, Ayala V, Auge N, Sanson M, Elbaz M, Thiers JC, Pamplona R, Salvayre R, Nègre-Salvayre A
FASEB J. 2007
PubMed ID: 17504976
-
Thymosin beta4 upregulates the expression of hepatocyte growth factor and downregulates the expression of PDGF-beta receptor in human hepatic stellate cells.
Barnaeva E, Nadezhda A, Hannappel E, Sjogren MH, Rojkind M
Ann N Y Acad Sci. 2007
PubMed ID: 17584975
-
PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Griffin TJ, Kim DH
J Biol Chem. 2007
PubMed ID: 17599906
-
Melittin, a major bioactive component of bee venom toxin, inhibits PDGF receptor beta-tyrosine phosphorylation and downstream intracellular signal transduction in rat aortic vascular smooth muscle cells.
Son DJ, Kang J, Kim TJ, Song HS, Sung KJ, Yun do Y, Hong JT
J Toxicol Environ Health A. 2007
PubMed ID: 17654254
-
Mesenchymal cells are required for functional development of thymic epithelial cells.
Itoi M, Tsukamoto N, Yoshida H, Amagai T
Int Immunol. 2007
PubMed ID: 17625108
-
Novel loci regulating bone anabolic response to loading: expression QTL analysis in C57BL/6JXC3H/HeJ mice cross.
Kesavan C, Baylink DJ, Kapoor S, Mohan S
Bone. 2007
PubMed ID: 17543594
-
Platelet-derived growth factor (PDGF)-BB inhibits AMPA receptor-mediated synaptic transmission via PDGF receptor-beta in murine nucleus tractus solitarius.
Ohi Y, Ishii Y, Haji A, Noguchi S, Sasaoka T, Fujimori T, Nabeshima Y, Sasahara M, Hattori Y
Brain Res. 2007
PubMed ID: 17573050
-
Packing contacts can mediate highly specific interactions between artificial transmembrane proteins and the PDGFbeta receptor.
Ptacek JB, Edwards AP, Freeman-Cook LL, DiMaio D
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17609376
-
Stimulatory autoantibodies to PDGF receptor in patients with extensive chronic graft-versus-host disease.
Svegliati S, Olivieri A, Campelli N, Luchetti M, Poloni A, Trappolini S, Moroncini G, Bacigalupo A, Leoni P, Avvedimento EV, Gabrielli A
Blood. 2007
PubMed ID: 17363728
-
Cooperation between the PDGF receptors in cardiac neural crest cell migration.
Richarte AM, Mead HB, Tallquist MD
Dev Biol. 2007
PubMed ID: 17499702
-
An antibody directed against PDGF receptor beta enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody.
Shen J, Vil MD, Zhang H, Tonra JR, Rong LL, Damoci C, Prewett M, Deevi DS, Kearney J, Surguladze D, Jimenez X, Iacolina M, Bassi R, Zhou K, Balderes P, Mangalampalli VR, Loizos N, Ludwig DL, Zhu Z
Biochem Biophys Res Commun. 2007
PubMed ID: 17462601
-
Detection of COL1A1-PDGFB fusion transcripts and PDGFB/PDGFRB mRNA expression in dermatofibrosarcoma protuberans.
Takahira T, Oda Y, Tamiya S, Higaki K, Yamamoto H, Kobayashi C, Izumi T, Tateishi N, Iwamoto Y, Tsuneyoshi M
Mod Pathol. 2007
PubMed ID: 17431412
-
The Lipoxin A4 receptor is coupled to SHP-2 activation: implications for regulation of receptor tyrosine kinases.
Mitchell D, O'Meara SJ, Gaffney A, Crean JK, Kinsella BT, Godson C
J Biol Chem. 2007
PubMed ID: 17403678
-
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
Ball SG, Shuttleworth CA, Kielty CM
J Cell Biol. 2007
PubMed ID: 17470632
-
Expression of endothelial PDGF receptors alpha and beta in breast cancer: up-regulation of endothelial PDGF receptor beta.
Vrekoussis T, Stathopoulos EN, Kafousi M, Navrozoglou I, Zoras O
Oncol Rep. 2007
PubMed ID: 17390053
-
Human cytomegalovirus downregulates expression of receptors for platelet-derived growth factor by smooth muscle cells.
Gredmark S, Strååt K, Homman-Loudiyi M, Kannisto K, Söderberg-Nauclér C
J Virol. 2007
PubMed ID: 17344284
-
Identification and distribution of a novel platelet-derived growth factor receptor beta variant: effect of retinoic acid and involvement in cell differentiation.
Wang Y, Culty M
Endocrinology. 2007
PubMed ID: 17303670
-
Constitutive diffuse activation of phosphoinositide 3-kinase at the plasma membrane by v-Src suppresses the chemotactic response to PDGF by abrogating the polarity of PDGF receptor signalling.
Platek A, Vassilev VS, de Diesbach P, Tyteca D, Mettlen M, Courtoy PJ
Exp Cell Res. 2007
PubMed ID: 17335807
-
A new NDE1/PDGFRB fusion transcript underlying chronic myelomonocytic leukaemia in Noonan Syndrome.
La Starza R, Rosati R, Roti G, Gorello P, Bardi A, Crescenzi B, Pierini V, Calabrese O, Baens M, Folens C, Cools J, Marynen P, Martelli MF, Mecucci C, Cuneo A
Leukemia. 2007
PubMed ID: 17301821
-
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
-
Expression of platelet-derived growth factor receptor in low-grade endometrial stromal sarcomas in the absence of activating mutations.
Liegl B, Gülly C, Reich O, Nogales FF, Beham A, Regauer S
Histopathology. 2007
PubMed ID: 17448020
-
TNF-alpha induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-kappaB/p300 binding in human tracheal smooth muscle cells.
Lee CW, Lin CC, Lin WN, Liang KC, Luo SF, Wu CB, Wang SW, Yang CM
Am J Physiol Lung Cell Mol Physiol. 2007
PubMed ID: 17158602
-
Characterization of three new imatinib-responsive fusion genes in chronic myeloproliferative disorders generated by disruption of the platelet-derived growth factor receptor beta gene.
Walz C, Metzgeroth G, Haferlach C, Schmitt-Graeff A, Fabarius A, Hagen V, Prümmer O, Rauh S, Hehlmann R, Hochhaus A, Cross NC, Reiter A
Haematologica. 2007
PubMed ID: 17296564
-
Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development.
Abramsson A, Kurup S, Busse M, Yamada S, Lindblom P, Schallmeiner E, Stenzel D, Sauvaget D, Ledin J, Ringvall M, Landegren U, Kjellén L, Bondjers G, Li JP, Lindahl U, Spillmann D, Betsholtz C, Gerhardt H
Genes Dev. 2007
PubMed ID: 17289920
-
Platelet-derived growth factor receptor-beta, carrying the activating mutation D849N, accelerates the establishment of B16 melanoma.
Suzuki S, Heldin CH, Heuchel RL
BMC Cancer. 2007
PubMed ID: 18076756
-
An activating mutation in the PDGF receptor-beta causes abnormal morphology in the mouse placenta.
Looman C, Sun T, Yu Y, Zieba A, Ahgren A, Feinstein R, Forsberg H, Hellberg C, Heldin CH, Zhang XQ, Forsberg-Nilsson K, Khoo N, Fundele R, Heuchel R
Int J Dev Biol. 2007
PubMed ID: 17616925
-
Oligohydramnios decreases platelet-derived growth factor expression in fetal rat lungs.
Chen CM, Wang LF, Chou HC, Lang YD
Neonatology. 2007
PubMed ID: 17519529
-
PDGF receptors as targets in tumor treatment.
Ostman A, Heldin CH
Adv Cancer Res. 2007
PubMed ID: 17419949
-
Protein expression of KIT and gene mutation of c-kit and PDGFRs in Ewing sarcomas.
Do I, Araujo ES, Kalil RK, Bacchini P, Bertoni F, Unni KK, Park YK
Pathol Res Pract. 2007
PubMed ID: 17298867
-
The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors.
Lierman E, Lahortiga I, Van Miegroet H, Mentens N, Marynen P, Cools J
Haematologica. 2007
PubMed ID: 17229632
-
PDGF signaling specificity is mediated through multiple immediate early genes.
Schmahl J, Raymond CS, Soriano P
Nat Genet. 2007
PubMed ID: 17143286
-
Alix facilitates the interaction between c-Cbl and platelet-derived growth factor beta-receptor and thereby modulates receptor down-regulation.
Lennartsson J, Wardega P, Engström U, Hellman U, Heldin CH
J Biol Chem. 2006
PubMed ID: 17082185
-
Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing.
Rajkumar VS, Shiwen X, Bostrom M, Leoni P, Muddle J, Ivarsson M, Gerdin B, Denton CP, Bou-Gharios G, Black CM, Abraham DJ
Am J Pathol. 2006
PubMed ID: 17148686
-
Molecular and biochemical analyses of platelet-derived growth factor receptor (PDGFR) B, PDGFRA, and KIT receptors in chordomas.
Tamborini E, Miselli F, Negri T, Lagonigro MS, Staurengo S, Dagrada GP, Stacchiotti S, Pastore E, Gronchi A, Perrone F, Carbone A, Pierotti MA, Casali PG, Pilotti S
Clin Cancer Res. 2006
PubMed ID: 17145809
-
Klf2 is an essential regulator of vascular hemodynamic forces in vivo.
Lee JS, Yu Q, Shin JT, Sebzda E, Bertozzi C, Chen M, Mericko P, Stadtfeld M, Zhou D, Cheng L, Graf T, MacRae CA, Lepore JJ, Lo CW, Kahn ML
Dev Cell. 2006
PubMed ID: 17141159
-
PI3K is involved in PDGF-beta receptor upregulation post-PDGF-BB treatment in mouse HSC.
Lechuga CG, Hernández-Nazara ZH, Hernández E, Bustamante M, Desierto G, Cotty A, Dharker N, Choe M, Rojkind M
Am J Physiol Gastrointest Liver Physiol. 2006
PubMed ID: 16990448
-
A novel DNA vaccine encoding PDGFRbeta suppresses growth and dissemination of murine colon, lung and breast carcinoma.
Kaplan CD, Krüger JA, Zhou H, Luo Y, Xiang R, Reisfeld RA
Vaccine. 2006
PubMed ID: 17050049
-
Loss of T-cell protein tyrosine phosphatase induces recycling of the platelet-derived growth factor (PDGF) beta-receptor but not the PDGF alpha-receptor.
Karlsson S, Kowanetz K, Sandin A, Persson C, Ostman A, Heldin CH, Hellberg C
Mol Biol Cell. 2006
PubMed ID: 16971512
-
c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells.
Choudhury GG, Mahimainathan L, Das F, Venkatesan B, Ghosh-Choudhury N
Cell Signal. 2006
PubMed ID: 16530387
-
Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation.
Rolny C, Nilsson I, Magnusson P, Armulik A, Jakobsson L, Wentzel P, Lindblom P, Norlin J, Betsholtz C, Heuchel R, Welsh M, Claesson-Welsh L
Blood. 2006
PubMed ID: 16690964
-
Comparative transcriptional and functional profiling of clear cell and papillary renal cell carcinoma.
Diegmann J, Tomiuk S, Sanjmyatav J, Junker K, Hindermann W, von Eggeling F
Int J Mol Med. 2006
PubMed ID: 16865223
-
Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle.
Gosens R, Stelmack GL, Dueck G, McNeill KD, Yamasaki A, Gerthoffer WT, Unruh H, Gounni AS, Zaagsma J, Halayko AJ
Am J Physiol Lung Cell Mol Physiol. 2006
PubMed ID: 16617096
-
Pleural malignant solitary fibrous tumor with sarcomatous overgrowth showing PDGFRbeta mutation.
Rossi G, Schirosi L, Giovanardi F, Sartori G, Paci M, Cavazza A
Chest. 2006
PubMed ID: 16899864
-
Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes.
Bondjers C, He L, Takemoto M, Norlin J, Asker N, Hellström M, Lindahl P, Betsholtz C
FASEB J. 2006
PubMed ID: 16807374
-
Angiotensin II stimulates phosphorylation of an ectodomain-truncated platelet-derived growth factor receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells.
Gao BB, Hansen H, Chen HC, Feener EP
Biochem J. 2006
PubMed ID: 16569213
-
PDGF and microvessel wall remodeling in adult lung: imaging PDGF-Rbeta and PDGF-BB molecules in progenitor smooth muscle cells developing in pulmonary hypertension.
Jones R, Capen D, Jacobson M
Ultrastruct Pathol. 2006
PubMed ID: 16971352
-
The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor.
Long JS, Natarajan V, Tigyi G, Pyne S, Pyne NJ
Prostaglandins Other Lipid Mediat. 2006
PubMed ID: 16846788
-
Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury.
Ishii Y, Oya T, Zheng L, Gao Z, Kawaguchi M, Sabit H, Matsushima T, Tokunaga A, Ishizawa S, Hori E, Nabeshima Y, Sasaoka T, Fujimori T, Mori H, Sasahara M
J Neurochem. 2006
PubMed ID: 16805849
-
Autocrine PDGFR signaling promotes mammary cancer metastasis.
Jechlinger M, Sommer A, Moriggl R, Seither P, Kraut N, Capodiecci P, Donovan M, Cordon-Cardo C, Beug H, Grünert S
J Clin Invest. 2006
PubMed ID: 16741576
-
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
-
Large-scale identification of genes implicated in kidney glomerulus development and function.
Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S, Miura N, Sado Y, Alitalo K, Quaggin SE, Tryggvason K, Betsholtz C
EMBO J. 2006
PubMed ID: 16498405
-
PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling.
Takahashi Y, Morales FC, Kreimann EL, Georgescu MM
EMBO J. 2006
PubMed ID: 16456542
-
Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells.
Chen CN, Li YS, Yeh YT, Lee PL, Usami S, Chien S, Chiu JJ
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16477012
-
Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly.
Foo SS, Turner CJ, Adams S, Compagni A, Aubyn D, Kogata N, Lindblom P, Shani M, Zicha D, Adams RH
Cell. 2006
PubMed ID: 16413489
-
Expression of tyrosine kinase receptors in malignant midgut carcinoid tumors.
Welin S, Fjällskog ML, Saras J, Eriksson B, Janson ET
Neuroendocrinology. 2006
PubMed ID: 17047316
-
Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis.
Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P
Cancer Immun. 2006
PubMed ID: 16875435
-
Serum starvation and growth factor receptor expression in vascular smooth muscle cells.
Zimmermann O, Zwaka TP, Marx N, Torzewski M, Bucher A, Guilliard P, Hannekum A, Hombach V, Torzewski J
J Vasc Res. 2006
PubMed ID: 16407661
-
Nicotinic and PDGF-receptor function are essential for nicotine-stimulated mitogenesis in human vascular smooth muscle cells.
Pestana IA, Vazquez-Padron RI, Aitouche A, Pham SM
J Cell Biochem. 2005
PubMed ID: 16149045
-
Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice.
Pontén A, Folestad EB, Pietras K, Eriksson U
Circ Res. 2005
PubMed ID: 16224065
-
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
-
Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by alpha platelet-derived growth factor receptor.
Dolloff NG, Shulby SS, Nelson AV, Stearns ME, Johannes GJ, Thomas JD, Meucci O, Fatatis A
Oncogene. 2005
PubMed ID: 16007172
-
Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells (HSC).
Breitkopf K, Roeyen C, Sawitza I, Wickert L, Floege J, Gressner AM
Cytokine. 2005
PubMed ID: 16039137
-
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
-
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
-
The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition.
Wu JH, Goswami R, Kim LK, Miller WE, Peppel K, Freedman NJ
J Biol Chem. 2005
PubMed ID: 15994317
-
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis.
Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A
Genes Dev. 2005
PubMed ID: 16107612
-
Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling.
Rolny C, Lu L, Agren N, Nilsson I, Roe C, Webb GC, Welsh M
Exp Cell Res. 2005
PubMed ID: 15919073
-
Arf-dependent regulation of Pdgf signaling in perivascular cells in the developing mouse eye.
Silva RL, Thornton JD, Martin AC, Rehg JE, Bertwistle D, Zindy F, Skapek SX
EMBO J. 2005
PubMed ID: 16037818
-
Platelet-derived growth factor receptor-beta (PDGFR-beta) activation promotes its association with the low density lipoprotein receptor-related protein (LRP). Evidence for co-receptor function.
Newton CS, Loukinova E, Mikhailenko I, Ranganathan S, Gao Y, Haudenschild C, Strickland DK
J Biol Chem. 2005
PubMed ID: 15944146
-
Sphingosine-1-phosphate induces a PDGFR-dependent cell detachment via inhibiting beta1 integrin in HEK293 cells.
Zaslavsky A, Li S, Xu Y
FEBS Lett. 2005
PubMed ID: 15987639
-
Inhibition of PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction in rat aortic vascular smooth muscle cells by kaempferol.
Kim SY, Jin YR, Lim Y, Kim JH, Cho MR, Hong JT, Yoo HS, Yun YP
Planta Med. 2005
PubMed ID: 16041643
-
Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model.
Xu L, Tong R, Cochran DM, Jain RK
Cancer Res. 2005
PubMed ID: 15994946
-
Contractile activity of skeletal musculature involved in breathing is essential for normal lung cell differentiation, as revealed in Myf5-/-:MyoD-/- embryos.
Inanlou MR, Kablar B
Dev Dyn. 2005
PubMed ID: 15844178
-
A-Raf associates with and regulates platelet-derived growth factor receptor signalling.
Mahon ES, Hawrysh AD, Chagpar RB, Johnson LM, Anderson DH
Cell Signal. 2005
PubMed ID: 15763428
-
Effects of ribozyme targeting platelet-derived growth factor receptor beta subunit gene on the proliferation and apoptosis of hepatic stellate cells in vitro.
Chen YX, Lu CH, Xie WF, Zhang XR, Zhang ZB, Wei LX, Jin YX, Guo YJ
Chin Med J (Engl). 2005
PubMed ID: 15978205
-
Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineages.
Brachvogel B, Moch H, Pausch F, Schlötzer-Schrehardt U, Hofmann C, Hallmann R, von der Mark K, Winkler T, Pöschl E
Development. 2005
PubMed ID: 15857912
-
A role for platelet-derived growth factor beta-receptor in a newborn rat model of endothelin-mediated pulmonary vascular remodeling.
Jankov RP, Kantores C, Belcastro R, Yi S, Ridsdale RA, Post M, Tanswell AK
Am J Physiol Lung Cell Mol Physiol. 2005
PubMed ID: 15722379
-
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II.
Choi MH, Lee IK, Kim GW, Kim BU, Han YH, Yu DY, Park HS, Kim KY, Lee JS, Choi C, Bae YS, Lee BI, Rhee SG, Kang SW
Nature. 2005
PubMed ID: 15902258
-
Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta.
Kiyan J, Kiyan R, Haller H, Dumler I
EMBO J. 2005
PubMed ID: 15889147
-
Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells. Only phosphatidylinositol 3'-kinase is important.
Vantler M, Caglayan E, Zimmermann WH, Bäumer AT, Rosenkranz S
J Biol Chem. 2005
PubMed ID: 15640155
-
PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts.
Cairo S, De Falco F, Pizzo M, Salomoni P, Pandolfi PP, Meroni G
Oncogene. 2005
PubMed ID: 15735755
-
Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing.
Gao Z, Sasaoka T, Fujimori T, Oya T, Ishii Y, Sabit H, Kawaguchi M, Kurotaki Y, Naito M, Wada T, Ishizawa S, Kobayashi M, Nabeshima Y, Sasahara M
J Biol Chem. 2005
PubMed ID: 15590688
-
Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers.
Wilczynski SP, Chen YY, Chen W, Howell SB, Shively JE, Alberts DS
Hum Pathol. 2005
PubMed ID: 15791568
-
Calcitriol inhibits growth response to Platelet-Derived Growth Factor-BB in human prostate cells.
Nazarova N, Golovko O, Bläuer M, Tuohimaa P
J Steroid Biochem Mol Biol. 2005
PubMed ID: 15862965
-
Productive interaction between transmembrane mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor beta receptor.
Lai CC, Edwards AP, DiMaio D
J Virol. 2005
PubMed ID: 15650217
-
Combined vascular endothelial growth factor and platelet-derived growth factor inhibition in rat cardiac allografts: beneficial effects on inflammation and smooth muscle cell proliferation.
Nykänen AI, Krebs R, Tikkanen JM, Raisky O, Sihvola R, Wood J, Koskinen PK, Lemström KB
Transplantation. 2005
PubMed ID: 15665766
-
Regulation of chemotaxis by the cytoplasmic domain of tissue factor.
Siegbahn A, Johnell M, Sorensen BB, Petersen LC, Heldin CH
Thromb Haemost. 2005
PubMed ID: 15630487
-
Substrate-trapping techniques in the identification of cellular PTP targets.
Blanchetot C, Chagnon M, Dubé N, Hallé M, Tremblay ML
Methods. 2005
PubMed ID: 15588985
-
Abnormal development of the intercostal muscles and the rib cage in Myf5-/- embryos leads to pulmonary hypoplasia.
Inanlou MR, Kablar B
Dev Dyn. 2005
PubMed ID: 15580568
-
Protocadherin 12 (VE-cadherin 2) is expressed in endothelial, trophoblast, and mesangial cells.
Rampon C, Prandini MH, Bouillot S, Pointu H, Tillet E, Frank R, Vernet M, Huber P
Exp Cell Res. 2005
PubMed ID: 15541725
-
Insulin inhibits platelet-derived growth factor-induced cell proliferation.
Cirri P, Taddei ML, Chiarugi P, Buricchi F, Caselli A, Paoli P, Giannoni E, Camici G, Manao G, Raugei G, Ramponi G
Mol Biol Cell. 2005
PubMed ID: 15525682
-
Type I collagen synergistically enhances PDGF-induced smooth muscle cell proliferation through pp60src-dependent crosstalk between the alpha2beta1 integrin and PDGFbeta receptor.
Hollenbeck ST, Itoh H, Louie O, Faries PL, Liu B, Kent KC
Biochem Biophys Res Commun. 2004
PubMed ID: 15522237
-
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
-
Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice.
Pitera JE, Woolf AS, Gale NW, Yancopoulos GD, Yuan HT
Am J Pathol. 2004
PubMed ID: 15579434
-
The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins.
Chamberlain MD, Berry TR, Pastor MC, Anderson DH
J Biol Chem. 2004
PubMed ID: 15377662
-
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system.
Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, Bréant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A
Nature. 2004
PubMed ID: 15510105
-
Platelet-derived growth factor stimulates glucose transport in skeletal muscles of transgenic mice specifically expressing platelet-derived growth factor receptor in the muscle, but it does not affect blood glucose levels.
Yuasa T, Kakuhata R, Kishi K, Obata T, Shinohara Y, Bando Y, Izumi K, Kajiura F, Matsumoto M, Ebina Y
Diabetes. 2004
PubMed ID: 15504957
-
Development of hygromas or severe edema during treatment with the tyrosine kinase inhibitor STI571 is not associated with platelet-derived growth factor receptor (PDGFR) gene polymorphisms.
Brück P, Wassmann B, Lopez ER, Hoelzer D, Ottmann OG
Leuk Res. 2004
PubMed ID: 15380338
-
p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder.
Grand FH, Burgstaller S, Kühr T, Baxter EJ, Webersinke G, Thaler J, Chase AJ, Cross NC
Cancer Res. 2004
PubMed ID: 15492236
-
p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor.
Uramoto H, Wetterskog D, Hackzell A, Matsumoto Y, Funa K
J Cell Sci. 2004
PubMed ID: 15454570
-
A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity.
Chiara F, Goumans MJ, Forsberg H, Ahgrén A, Rasola A, Aspenström P, Wernstedt C, Hellberg C, Heldin CH, Heuchel R
J Biol Chem. 2004
PubMed ID: 15284236
-
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
-
Signal peptide prediction based on analysis of experimentally verified cleavage sites.
Zhang Z, Henzel WJ
Protein Sci. 2004
PubMed ID: 15340161
-
Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor.
Hildreth KL, Wu JH, Barak LS, Exum ST, Kim LK, Peppel K, Freedman NJ
J Biol Chem. 2004
PubMed ID: 15271984
-
The DNA sequence and comparative analysis of human chromosome 5.
Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM
Nature. 2004
PubMed ID: 15372022
-
Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis.
Petrova TV, Karpanen T, Norrmén C, Mellor R, Tamakoshi T, Finegold D, Ferrell R, Kerjaschki D, Mortimer P, Ylä-Herttuala S, Miura N, Alitalo K
Nat Med. 2004
PubMed ID: 15322537
-
Embryonic mouse testis development: role of platelet derived growth factor (PDGF-BB).
Ricci G, Catizone A, Galdieri M
J Cell Physiol. 2004
PubMed ID: 15254974
-
pRb, Myc and p53 are critically involved in SV40 large T antigen repression of PDGF beta-receptor transcription.
Uramoto H, Hackzell A, Wetterskog D, Ballági A, Izumi H, Funa K
J Cell Sci. 2004
PubMed ID: 15265983
-
PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma.
Ostman A
Cytokine Growth Factor Rev. 2004
PubMed ID: 15207817
-
Positive and negative regulatory roles of the WW-like domain in TEL-PDGFbetaR transformation.
Chen J, Williams IR, Kutok JL, Duclos N, Anastasiadou E, Masters SC, Fu H, Gilliland DG
Blood. 2004
PubMed ID: 15054045
-
PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development.
Gitler AD, Lu MM, Epstein JA
Dev Cell. 2004
PubMed ID: 15239958
-
Expression of platelet-derived growth factor in the developing cochlea of rats.
Lee YW, Ozeki M, Juhn SK, Lin J
Acta Otolaryngol. 2004
PubMed ID: 15267171
-
Forced expression of platelet-derived growth factor B in the mouse cerebellar primordium changes cell migration during midline fusion and causes cerebellar ectopia.
Andrae J, Afink G, Zhang XQ, Wurst W, Nistér M
Mol Cell Neurosci. 2004
PubMed ID: 15207855
-
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW
Nat Biotechnol. 2004
PubMed ID: 15146197
-
Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis.
Borkham-Kamphorst E, Herrmann J, Stoll D, Treptau J, Gressner AM, Weiskirchen R
Lab Invest. 2004
PubMed ID: 15077122
-
Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2.
Finlay GA, York B, Karas RH, Fanburg BL, Zhang H, Kwiatkowski DJ, Noonan DJ
J Biol Chem. 2004
PubMed ID: 15039427
-
Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail.
Chiara F, Bishayee S, Heldin CH, Demoulin JB
J Biol Chem. 2004
PubMed ID: 14996833
-
Extra-embryonic vasculature development is regulated by the transcription factor HAND1.
Morikawa Y, Cserjesi P
Development. 2004
PubMed ID: 15073150
-
Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells.
Tanimoto T, Lungu AO, Berk BC
Circ Res. 2004
PubMed ID: 15044318
-
Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor.
Kallin A, Demoulin JB, Nishida K, Hirano T, Rönnstrand L, Heldin CH
J Biol Chem. 2004
PubMed ID: 14973141
-
HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2).
Morerio C, Acquila M, Rosanda C, Rapella A, Dufour C, Locatelli F, Maserati E, Pasquali F, Panarello C
Cancer Res. 2004
PubMed ID: 15087372
-
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
-
Glomerular expression of platelet-derived growth factor (PDGF)-A, -B chain and PDGF receptor-alpha, -beta in human diabetic nephropathy.
Uehara G, Suzuki D, Toyoda M, Umezono T, Sakai H
Clin Exp Nephrol. 2004
PubMed ID: 15067514
-
Expression and role of PDGF-BB and PDGFR-beta during testis morphogenesis in the mouse embryo.
Puglianiello A, Campagnolo L, Farini D, Cipollone D, Russo MA, Siracusa G
J Cell Sci. 2004
PubMed ID: 14996938
-
Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.
Plattner R, Koleske AJ, Kazlauskas A, Pendergast AM
Mol Cell Biol. 2004
PubMed ID: 14993293
-
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.
Persson C, Sävenhed C, Bourdeau A, Tremblay ML, Markova B, Böhmer FD, Haj FG, Neel BG, Elson A, Heldin CH, Rönnstrand L, Ostman A, Hellberg C
Mol Cell Biol. 2004
PubMed ID: 14966296
-
Expression of ligand-activated KIT and platelet-derived growth factor receptor beta tyrosine kinase receptors in synovial sarcoma.
Tamborini E, Bonadiman L, Greco A, Gronchi A, Riva C, Bertulli R, Casali PG, Pierotti MA, Pilotti S
Clin Cancer Res. 2004
PubMed ID: 14871970
-
S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR).
Baudhuin LM, Jiang Y, Zaslavsky A, Ishii I, Chun J, Xu Y
FASEB J. 2004
PubMed ID: 14657000
-
High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib.
Al-Ali HK, Heinrich MC, Lange T, Krahl R, Mueller M, Müller C, Niederwieser D, Druker BJ, Deininger MW
Hematol J. 2004
PubMed ID: 14745431
-
Expression of platelet-derived growth factor (PDGF) in the epididymis and analysis of the epididymal development in PDGF-A, PDGF-B, and PDGF receptor beta deficient mice.
Basciani S, Mariani S, Arizzi M, Brama M, Ricci A, Betsholtz C, Bondjers C, Ricci G, Catizone A, Galdieri M, Spera G, Gnessi L
Biol Reprod. 2004
PubMed ID: 14522834
-
Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation.
Fraenzer JT, Pan H, Minimo L, Smith GM, Knauer D, Hung G
Int J Oncol. 2003
PubMed ID: 14612918
-
Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib.
Wilkinson K, Velloso ER, Lopes LF, Lee C, Aster JC, Shipp MA, Aguiar RC
Blood. 2003
PubMed ID: 12907457
-
Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development.
Tallquist MD, French WJ, Soriano P
PLoS Biol. 2003
PubMed ID: 14624252
-
YXXM motifs in the PDGF-beta receptor serve dual roles as phosphoinositide 3-kinase binding motifs and tyrosine-based endocytic sorting signals.
Wu H, Windmiller DA, Wang L, Backer JM
J Biol Chem. 2003
PubMed ID: 12941951
-
Regulation of PDGF and PDGF receptor in cultured dermal papilla cells and follicular keratinocytes of the human hair follicle.
Kamp H, Geilen CC, Sommer C, Blume-Peytavi U
Exp Dermatol. 2003
PubMed ID: 14705808
-
Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury.
Taneda S, Hudkins KL, Topouzis S, Gilbertson DG, Ophascharoensuk V, Truong L, Johnson RJ, Alpers CE
J Am Soc Nephrol. 2003
PubMed ID: 14514732
-
Chimera analysis supports a predominant role of PDGFRbeta in promoting smooth-muscle cell chemotaxis after arterial injury.
Buetow BS, Tappan KA, Crosby JR, Seifert RA, Bowen-Pope DF
Am J Pathol. 2003
PubMed ID: 12937138
-
Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates.
Whiteman EL, Chen JJ, Birnbaum MJ
Endocrinology. 2003
PubMed ID: 12933652
-
Pattern formation of vascular smooth muscle cells subject to nonuniform fluid shear stress: role of PDGF-beta receptor and Src.
Liu SQ, Tieche C, Tang D, Alkema P
Am J Physiol Heart Circ Physiol. 2003
PubMed ID: 12738619
-
Dynamic recruitment of NF-Y and histone acetyltransferases on cell-cycle promoters.
Caretti G, Salsi V, Vecchi C, Imbriano C, Mantovani R
J Biol Chem. 2003
PubMed ID: 12771133
-
Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury.
Takikita-Suzuki M, Haneda M, Sasahara M, Owada MK, Nakagawa T, Isono M, Takikita S, Koya D, Ogasawara K, Kikkawa R
Am J Pathol. 2003
PubMed ID: 12819032
-
Gab1 is an integrator of cell death versus cell survival signals in oxidative stress.
Holgado-Madruga M, Wong AJ
Mol Cell Biol. 2003
PubMed ID: 12808090
-
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation.
Haglund K, Sigismund S, Polo S, Szymkiewicz I, Di Fiore PP, Dikic I
Nat Cell Biol. 2003
PubMed ID: 12717448
-
Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells.
Uren A, Merchant MS, Sun CJ, Vitolo MI, Sun Y, Tsokos M, Illei PB, Ladanyi M, Passaniti A, Mackall C, Toretsky JA
Oncogene. 2003
PubMed ID: 12700668
-
Stimulation of the alpha1A adrenergic receptor inhibits PDGF-induced PDGF beta receptor Tyr751 phosphorylation and PI 3-kinase activation.
Lin HY, Ballou LM, Lin RZ
FEBS Lett. 2003
PubMed ID: 12681492
-
Domain-dependent modulation of PDGFRbeta by ganglioside GM1.
Oblinger JL, Boardman CL, Yates AJ, Burry RW
J Mol Neurosci. 2003
PubMed ID: 12794304
-
Prenatal exposure to estrogenic compounds alters the expression pattern of platelet-derived growth factor receptors alpha and beta in neonatal rat testis: identification of gonocytes as targets of estrogen exposure.
Thuillier R, Wang Y, Culty M
Biol Reprod. 2003
PubMed ID: 12604637
-
Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells.
Bondjers C, Kalén M, Hellström M, Scheidl SJ, Abramsson A, Renner O, Lindahl P, Cho H, Kehrl J, Betsholtz C
Am J Pathol. 2003
PubMed ID: 12598306
-
A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development.
Takahashi T, Takahashi K, St John PL, Fleming PA, Tomemori T, Watanabe T, Abrahamson DR, Drake CJ, Shirasawa T, Daniel TO
Mol Cell Biol. 2003
PubMed ID: 12588999
-
Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells.
Waters C, Sambi B, Kong KC, Thompson D, Pitson SM, Pyne S, Pyne NJ
J Biol Chem. 2003
PubMed ID: 12480944
-
Photoreceptor-specific overexpression of platelet-derived growth factor induces proliferation of endothelial cells, pericytes, and glial cells and aberrant vascular development: an ultrastructural and immunocytochemical study.
Vinores SA, Seo MS, Derevjanik NL, Campochiaro PA
Brain Res Dev Brain Res. 2003
PubMed ID: 12586423
-
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
-
Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitization.
Freedman NJ, Kim LK, Murray JP, Exum ST, Brian L, Wu JH, Peppel K
J Biol Chem. 2002
PubMed ID: 12381737
-
Molecular examination of the transmembrane requirements of the platelet-derived growth factor beta receptor for a productive interaction with the bovine papillomavirus E5 oncoprotein.
Nappi VM, Schaefer JA, Petti LM
J Biol Chem. 2002
PubMed ID: 12351659
-
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
-
Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src.
Saito S, Frank GD, Mifune M, Ohba M, Utsunomiya H, Motley ED, Inagami T, Eguchi S
J Biol Chem. 2002
PubMed ID: 12226102
-
Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins.
McCarty JH, Monahan-Earley RA, Brown LF, Keller M, Gerhardt H, Rubin K, Shani M, Dvorak HF, Wolburg H, Bader BL, Dvorak AM, Hynes RO
Mol Cell Biol. 2002
PubMed ID: 12370313
-
CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.
Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I
J Biol Chem. 2002
PubMed ID: 12177062
-
p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y.
Hackzell A, Uramoto H, Izumi H, Kohno K, Funa K
J Biol Chem. 2002
PubMed ID: 12167641
-
Definition of an inhibitory juxtamembrane WW-like domain in the platelet-derived growth factor beta receptor.
Irusta PM, Luo Y, Bakht O, Lai CC, Smith SO, DiMaio D
J Biol Chem. 2002
PubMed ID: 12181311
-
Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice.
Kozaki K, Kaminski WE, Tang J, Hollenbach S, Lindahl P, Sullivan C, Yu JC, Abe K, Martin PJ, Ross R, Betsholtz C, Giese NA, Raines EW
Am J Pathol. 2002
PubMed ID: 12368212
-
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta.
Apperley JF, Gardembas M, Melo JV, Russell-Jones R, Bain BJ, Baxter EJ, Chase A, Chessells JM, Colombat M, Dearden CE, Dimitrijevic S, Mahon FX, Marin D, Nikolova Z, Olavarria E, Silberman S, Schultheis B, Cross NC, Goldman JM
N Engl J Med. 2002
PubMed ID: 12181402
-
Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor.
Saito Y, Hojo Y, Tanimoto T, Abe J, Berk BC
J Biol Chem. 2002
PubMed ID: 11940581
-
Structural determinants of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors.
Karthikeyan S, Leung T, Ladias JA
J Biol Chem. 2002
PubMed ID: 11882663
-
Expression of platelet-derived growth factor-A (PDGF-A), PDGF-B, and PDGF receptor-alpha and -beta during human testicular development and disease.
Basciani S, Mariani S, Arizzi M, Ulisse S, Rucci N, Jannini EA, Della Rocca C, Manicone A, Carani C, Spera G, Gnessi L
J Clin Endocrinol Metab. 2002
PubMed ID: 11994382
-
Role of platelet-derived growth factor receptor-mediated signal transduction in myocardial hypertrophy of spontaneously hypertensive rats.
Liu J, Bai H, Xing DQ, Sun YP, Wu LL
Sheng Li Xue Bao. 2002
PubMed ID: 11973598
-
Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1.
Persson C, Engström U, Mowbray SL, Ostman A
FEBS Lett. 2002
PubMed ID: 12062403
-
Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt.
Cartel NJ, Wang J, Post M
Biochem J. 2002
PubMed ID: 11903042
-
SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor.
Ekman S, Kallin A, Engström U, Heldin CH, Rönnstrand L
Oncogene. 2002
PubMed ID: 11896619
-
Enhancement of glomerular platelet-derived growth factor beta-receptor tyrosine phosphorylation in hypertensive rats and its inhibition by calcium channel blocker.
Zhan Y, Kim S, Kawano H, Iwao H
Hypertens Res. 2002
PubMed ID: 12047046
-
Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum.
Haj FG, Verveer PJ, Squire A, Neel BG, Bastiaens PI
Science. 2002
PubMed ID: 11872838
-
TEL/platelet-derived growth factor receptor beta activates phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle.
Dierov J, Xu Q, Dierova R, Carroll M
Blood. 2002
PubMed ID: 11861293
-
Association of a determinant on mouse chromosome 18 with experimental severe Plasmodium berghei malaria.
Nagayasu E, Nagakura K, Akaki M, Tamiya G, Makino S, Nakano Y, Kimura M, Aikawa M
Infect Immun. 2002
PubMed ID: 11796577
-
Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells.
Ricono JM, Arar M, Choudhury GG, Abboud HE
Am J Physiol Renal Physiol. 2002
PubMed ID: 11788434
-
Myeloproliferative disorders with translocations of chromosome 5q31-35: role of the platelet-derived growth factor receptor Beta.
Steer EJ, Cross NC
Acta Haematol. 2002
PubMed ID: 11919393
-
An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development.
Klinghoffer RA, Hamilton TG, Hoch R, Soriano P
Dev Cell. 2002
PubMed ID: 11782318
-
Age- and stage-specific regulation patterns in the hematopoietic stem cell hierarchy.
Geiger H, True JM, de Haan G, Van Zant G
Blood. 2001
PubMed ID: 11698278
-
[A preliminary study on the changes of expression of PDGF-beta, PDGFR-beta, TGF-beta 1, TGFR, bFGF and its relationship with the wound age in wound healing]
Wang HJ, Ruan HG, Huang GZ
Fa Yi Xue Za Zhi. 2001
PubMed ID: 12533868
-
NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis.
Ozerdem U, Grako KA, Dahlin-Huppe K, Monosov E, Stallcup WB
Dev Dyn. 2001
PubMed ID: 11668599
-
NMR trial models: experiences with the colicin immunity protein Im7 and the p85alpha C-terminal SH2-peptide complex.
Pauptit RA, Dennis CA, Derbyshire DJ, Breeze AL, Weston SA, Rowsell S, Murshudov GN
Acta Crystallogr D Biol Crystallogr. 2001
PubMed ID: 11567151
-
PDGF-BB-mediated activation of p42(MAPK) is independent of PDGF beta-receptor tyrosine phosphorylation.
Cartel NJ, Liu J, Wang J, Post M
Am J Physiol Lung Cell Mol Physiol. 2001
PubMed ID: 11557582
-
Regulation of cell growth by redox-mediated extracellular proteolysis of platelet-derived growth factor receptor beta.
Okuyama H, Shimahara Y, Kawada N, Seki S, Kristensen DB, Yoshizato K, Uyama N, Yamaoka Y
J Biol Chem. 2001
PubMed ID: 11346654
-
Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.
Gilbertson DG, Duff ME, West JW, Kelly JD, Sheppard PO, Hofstrand PD, Gao Z, Shoemaker K, Bukowski TR, Moore M, Feldhaus AL, Humes JM, Palmer TE, Hart CE
J Biol Chem. 2001
PubMed ID: 11297552
-
Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.
Deb A, Zamanian-Daryoush M, Xu Z, Kadereit S, Williams BR
EMBO J. 2001
PubMed ID: 11350938
-
PDGF-D, a new protease-activated growth factor.
LaRochelle WJ, Jeffers M, McDonald WF, Chillakuru RA, Giese NA, Lokker NA, Sullivan C, Boldog FL, Yang M, Vernet C, Burgess CE, Fernandes E, Deegler LL, Rittman B, Shimkets J, Shimkets RA, Rothberg JM, Lichenstein HS
Nat Cell Biol. 2001
PubMed ID: 11331882
-
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.
Bergsten E, Uutela M, Li X, Pietras K, Ostman A, Heldin CH, Alitalo K, Eriksson U
Nat Cell Biol. 2001
PubMed ID: 11331881
-
Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis.
Hellström M, Gerhardt H, Kalén M, Li X, Eriksson U, Wolburg H, Betsholtz C
J Cell Biol. 2001
PubMed ID: 11331305
-
Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice.
Kaminski WE, Lindahl P, Lin NL, Broudy VC, Crosby JR, Hellström M, Swolin B, Bowen-Pope DF, Martin PJ, Ross R, Betsholtz C, Raines EW
Blood. 2001
PubMed ID: 11264163
-
Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations.
Inukai K, Funaki M, Anai M, Ogihara T, Katagiri H, Fukushima Y, Sakoda H, Onishi Y, Ono H, Fujishiro M, Abe M, Oka Y, Kikuchi M, Asano T
FEBS Lett. 2001
PubMed ID: 11172806
-
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
-
The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions.
Klinghoffer RA, Mueting-Nelsen PF, Faerman A, Shani M, Soriano P
Mol Cell. 2001
PubMed ID: 11239463
-
Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation.
McCright B, Gao X, Shen L, Lozier J, Lan Y, Maguire M, Herzlinger D, Weinmaster G, Jiang R, Gridley T
Development. 2001
PubMed ID: 11171333
-
Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
Keilhack H, Müller M, Böhmer SA, Frank C, Weidner KM, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Günther B, Müller T, Birchmeier C, Böhmer FD
J Cell Biol. 2001
PubMed ID: 11266449
-
Sp1 is a key regulator of the PDGF beta-receptor transcription.
Molander C, Hackzell A, Ohta M, Izumi H, Funa K
Mol Biol Rep. 2001
PubMed ID: 12153142
-
Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain.
Borges E, Jan Y, Ruoslahti E
J Biol Chem. 2000
PubMed ID: 10964931
-
Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways.
Tallquist MD, Klinghoffer RA, Heuchel R, Mueting-Nelsen PF, Corrin PD, Heldin CH, Johnson RJ, Soriano P
Genes Dev. 2000
PubMed ID: 11124809
-
The protein tyrosine kinase family of the human genome.
Robinson DR, Wu YM, Lin SF
Oncogene. 2000
PubMed ID: 11114734
-
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
-
Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity.
Maudsley S, Zamah AM, Rahman N, Blitzer JT, Luttrell LM, Lefkowitz RJ, Hall RA
Mol Cell Biol. 2000
PubMed ID: 11046132
-
Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb.
Chen M, She H, Kim A, Woodley DT, Li W
Mol Cell Biol. 2000
PubMed ID: 11027258
-
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
-
Vav family proteins couple to diverse cell surface receptors.
Moores SL, Selfors LM, Fredericks J, Breit T, Fujikawa K, Alt FW, Brugge JS, Swat W
Mol Cell Biol. 2000
PubMed ID: 10938113
-
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
-
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.
Arcaro A, Zvelebil MJ, Wallasch C, Ullrich A, Waterfield MD, Domin J
Mol Cell Biol. 2000
PubMed ID: 10805725
-
Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1.
Kovalenko M, Denner K, Sandström J, Persson C, Gross S, Jandt E, Vilella R, Böhmer F, Ostman A
J Biol Chem. 2000
PubMed ID: 10821867
-
FAK integrates growth-factor and integrin signals to promote cell migration.
Sieg DJ, Hauck CR, Ilic D, Klingbeil CK, Schaefer E, Damsky CH, Schlaepfer DD
Nat Cell Biol. 2000
PubMed ID: 10806474
-
Immunohistochemical characterization of glomerular PDGF B-chain and PDGF beta-receptor expression in diabetic rats.
Nakagawa H, Sasahara M, Haneda M, Koya D, Hazama F, Kikkawa R
Diabetes Res Clin Pract. 2000
PubMed ID: 10802145
-
Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation.
Matsumoto T, Yokote K, Take A, Takemoto M, Asaumi S, Hashimoto Y, Matsuda M, Saito Y, Mori S
Biochem Biophys Res Commun. 2000
PubMed ID: 10733900
-
Platelet-derived growth factor receptor beta regulates migration and DNA synthesis in metanephric mesenchymal cells.
Arar M, Xu YC, Elshihabi I, Barnes JL, Choudhury GG, Abboud HE
J Biol Chem. 2000
PubMed ID: 10734101
-
PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis.
Riedel H, Yousaf N, Zhao Y, Dai H, Deng Y, Wang J
Oncogene. 2000
PubMed ID: 10644978
-
GM1 inhibits early signaling events mediated by PDGF receptor in cultured human glioma cells.
Farooqui T, Kelley T, Coggeshall KM, Rampersaud AA, Yates AJ
Anticancer Res. 1999
PubMed ID: 10697503
-
The Tel-PDGFRbeta fusion gene produces a chronic myeloproliferative syndrome in transgenic mice.
Ritchie KA, Aprikyan AA, Bowen-Pope DF, Norby-Slycord CJ, Conyers S, Bartelmez S, Sitnicka EH, Hickstein DD
Leukemia. 1999
PubMed ID: 10557054
-
Role of PDGF B-chain and PDGF receptors in rat tubular regeneration after acute injury.
Nakagawa T, Sasahara M, Haneda M, Kataoka H, Nakagawa H, Yagi M, Kikkawa R, Hazama F
Am J Pathol. 1999
PubMed ID: 10550325
-
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC
Science. 1999
PubMed ID: 10514377
-
Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling.
Heuchel R, Berg A, Tallquist M, Ahlén K, Reed RK, Rubin K, Claesson-Welsh L, Heldin CH, Soriano P
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10500190
-
Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.
Wang J, Dai H, Yousaf N, Moussaif M, Deng Y, Boufelliga A, Swamy OR, Leone ME, Riedel H
Mol Cell Biol. 1999
PubMed ID: 10454568
-
PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta.
Ohlsson R, Falck P, Hellström M, Lindahl P, Boström H, Franklin G, Ahrlund-Richter L, Pollard J, Soriano P, Betsholtz C
Dev Biol. 1999
PubMed ID: 10419690
-
Identification of a new quantitative trait locus on chromosome 7 controlling disease severity of collagen-induced arthritis in rats.
Dracheva SV, Remmers EF, Gulko PS, Kawahito Y, Longman RE, Reese VR, Cannon GW, Griffiths MM, Wilder RL
Immunogenetics. 1999
PubMed ID: 10398805
-
SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis.
Rönnstrand L, Arvidsson AK, Kallin A, Rorsman C, Hellman U, Engström U, Wernstedt C, Heldin CH
Oncogene. 1999
PubMed ID: 10391677
-
Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain.
Miyake S, Mullane-Robinson KP, Lill NL, Douillard P, Band H
J Biol Chem. 1999
PubMed ID: 10347229
-
Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse.
Hellström M, Kalén M, Lindahl P, Abramsson A, Betsholtz C
Development. 1999
PubMed ID: 10375497
-
Caveolin is an inhibitor of platelet-derived growth factor receptor signaling.
Yamamoto M, Toya Y, Jensen RA, Ishikawa Y
Exp Cell Res. 1999
PubMed ID: 10066366
-
Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.
Braverman LE, Quilliam LA
J Biol Chem. 1999
PubMed ID: 10026169
-
Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.
De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R
EMBO J. 1999
PubMed ID: 10022833
-
APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis.
Yokouchi M, Wakioka T, Sakamoto H, Yasukawa H, Ohtsuka S, Sasaki A, Ohtsubo M, Valius M, Inoue A, Komiya S, Yoshimura A
Oncogene. 1999
PubMed ID: 9989826
-
Tyrosine kinase activity of purified recombinant cytoplasmic domain of platelet-derived growth factor beta-receptor (beta-PDGFR) and discovery of a novel inhibitor of receptor tyrosine kinases.
Zaman GJ, Vink PM, van den Doelen AA, Veeneman GH, Theunissen HJ
Biochem Pharmacol. 1999
PubMed ID: 9920285
-
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
-
Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways.
Tu Y, Li F, Wu C
Mol Biol Cell. 1998
PubMed ID: 9843575
-
Identification of a family of sorting nexin molecules and characterization of their association with receptors.
Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI
Mol Cell Biol. 1998
PubMed ID: 9819414
-
Receptor tyrosine kinase expression in human bone marrow stromal cells.
Satomura K, Derubeis AR, Fedarko NS, Ibaraki-O'Connor K, Kuznetsov SA, Rowe DW, Young MF, Gehron Robey P
J Cell Physiol. 1998
PubMed ID: 9808151
-
Identification of Nck family genes, chromosomal localization, expression, and signaling specificity.
Chen M, She H, Davis EM, Spicer CM, Kim L, Ren R, Le Beau MM, Li W
J Biol Chem. 1998
PubMed ID: 9737977
-
Expression of platelet-derived growth factor and its receptors in the developing and adult mouse kidney.
Seifert RA, Alpers CE, Bowen-Pope DF
Kidney Int. 1998
PubMed ID: 9734598
-
Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli.
Lindahl P, Hellström M, Kalén M, Karlsson L, Pekny M, Pekna M, Soriano P, Betsholtz C
Development. 1998
PubMed ID: 9693135
-
Signal transduction via platelet-derived growth factor receptors.
Heldin CH, Ostman A, Rönnstrand L
Biochim Biophys Acta. 1998
PubMed ID: 9739761
-
Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern.
Dahlman I, Lorentzen JC, de Graaf KL, Stefferl A, Linington C, Luthman H, Olsson T
Eur J Immunol. 1998
PubMed ID: 9692888
-
The epidermal growth factor receptor associates with and recruits phosphatidylinositol 3-kinase to the platelet-derived growth factor beta receptor.
Habib AA, Högnason T, Ren J, Stefánsson K, Ratan RR
J Biol Chem. 1998
PubMed ID: 9506992
-
Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid.
Tanaka K, Nagayama Y, Nakano T, Takamura N, Namba H, Fukada S, Kuma K, Yamashita S, Niwa M
Endocrinology. 1998
PubMed ID: 9492013
-
Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains.
Valgeirsdóttir S, Paukku K, Silvennoinen O, Heldin CH, Claesson-Welsh L
Oncogene. 1998
PubMed ID: 9484840
-
PDGF-induced phosphorylation of Tyr28 in the N-terminus of Fyn affects Fyn activation.
Hansen K, Alonso G, Courtneidge SA, Rönnstrand L, Heldin CH
Biochem Biophys Res Commun. 1997
PubMed ID: 9425276
-
Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution.
Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H
Blood. 1997
PubMed ID: 9373237
-
Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor.
Tang J, Feng GS, Li W
Oncogene. 1997
PubMed ID: 9362449
-
Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development.
Lindahl P, Karlsson L, Hellström M, Gebre-Medhin S, Willetts K, Heath JK, Betsholtz C
Development. 1997
PubMed ID: 9374392
-
Integration of proviral DNA into the PDGF beta-receptor gene in HTLV-I-infected T-cells results in a novel tyrosine kinase product with transforming activity.
Chi KD, McPhee RA, Wagner AS, Dietz JJ, Pantazis P, Goustin AS
Oncogene. 1997
PubMed ID: 9285559
-
Reduced expression of PDGF and PDGF receptors during impaired wound healing.
Beer HD, Longaker MT, Werner S
J Invest Dermatol. 1997
PubMed ID: 9242497
-
Pericyte loss and microaneurysm formation in PDGF-B-deficient mice.
Lindahl P, Johansson BR, Levéen P, Betsholtz C
Science. 1997
PubMed ID: 9211853
-
Association of coatomer proteins with the beta-receptor for platelet-derived growth factor.
Hansen K, Rönnstrand L, Rorsman C, Hellman U, Heldin CH
Biochem Biophys Res Commun. 1997
PubMed ID: 9207175
-
Roles of platelet-derived growth factor in the developing and mature nervous systems.
Valenzuela CF, Kazlauskas A, Weiner JL
Brain Res Brain Res Rev. 1997
PubMed ID: 9233543
-
Nuclear factor Y controls the basal transcription activity of the mouse platelet-derived-growth-factor beta-receptor gene.
Ishisaki A, Murayama T, Ballagi AE, Funa K
Eur J Biochem. 1997
PubMed ID: 9210476
-
Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.
Saxton TM, Henkemeyer M, Gasca S, Shen R, Rossi DJ, Shalaby F, Feng GS, Pawson T
EMBO J. 1997
PubMed ID: 9171349
-
Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling.
Rani CS, Wang F, Fuior E, Berger A, Wu J, Sturgill TW, Beitner-Johnson D, LeRoith D, Varticovski L, Spiegel S
J Biol Chem. 1997
PubMed ID: 9099730
-
Isolation and characterization of the platelet-derived growth factor beta receptor promoter.
Shinbrot E, Liao X, Williams LT
Dev Dyn. 1997
PubMed ID: 9022058
-
Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains.
Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE
J Biol Chem. 1997
PubMed ID: 9006901
-
The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide ligand binding.
Broome MA, Hunter T
Oncogene. 1997
PubMed ID: 9010229
-
Gene expression of PDGF and PDGF receptor in various forms of glomerulonephritis.
Matsuda M, Shikata K, Makino H, Sugimoto H, Ota K, Akiyama K, Hirata K, Ota Z
Am J Nephrol. 1997
PubMed ID: 9057949
-
A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion.
Fujioka Y, Matozaki T, Noguchi T, Iwamatsu A, Yamao T, Takahashi N, Tsuda M, Takada T, Kasuga M
Mol Cell Biol. 1996
PubMed ID: 8943344
-
Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors.
Yokote K, Margolis B, Heldin CH, Claesson-Welsh L
J Biol Chem. 1996
PubMed ID: 8940081
-
HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.
Bardelli A, Longati P, Albero D, Goruppi S, Schneider C, Ponzetto C, Comoglio PM
EMBO J. 1996
PubMed ID: 8947043
-
Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways.
Roche S, McGlade J, Jones M, Gish GD, Pawson T, Courtneidge SA
EMBO J. 1996
PubMed ID: 8890167
-
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
-
A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats.
Remmers EF, Longman RE, Du Y, O'Hare A, Cannon GW, Griffiths MM, Wilder RL
Nat Genet. 1996
PubMed ID: 8782824
-
Binding to the platelet-derived growth factor receptor transiently activates the p85alpha-p110alpha phosphoinositide 3-kinase complex in vivo.
Domin J, Dhand R, Waterfield MD
J Biol Chem. 1996
PubMed ID: 8702949
-
Cloning and characterization of GRB14, a novel member of the GRB7 gene family.
Daly RJ, Sanderson GM, Janes PW, Sutherland RL
J Biol Chem. 1996
PubMed ID: 8647858
-
Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain.
Stover DR, Furet P, Lydon NB
J Biol Chem. 1996
PubMed ID: 8647855
-
Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins.
Vignais ML, Sadowski HB, Watling D, Rogers NC, Gilman M
Mol Cell Biol. 1996
PubMed ID: 8657151
-
Structural determinants in the platelet-derived growth factor alpha-receptor implicated in modulation of chemotaxis.
Yokote K, Mori S, Siegbahn A, Rönnstrand L, Wernstedt C, Heldin CH, Claesson-Welsh L
J Biol Chem. 1996
PubMed ID: 8617789
-
PDGF receptor-to-nucleus signaling of p91 (STAT1 alpha) transcription factor in rat smooth muscle cells.
Yamamoto H, Crow M, Cheng L, Lakatta E, Kinsella J
Exp Cell Res. 1996
PubMed ID: 8549654
-
The role of platelet-derived growth factor in the development of mouse molars.
Hu JC, Zhang C, Slavkin HC
Int J Dev Biol. 1995
PubMed ID: 8901196
-
Structure, organization, and transcription units of the human alpha-platelet-derived growth factor receptor gene, PDGFRA.
Kawagishi J, Kumabe T, Yoshimoto T, Yamamoto T
Genomics. 1995
PubMed ID: 8586421
-
A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains.
Songyang Z, Gish G, Mbamalu G, Pawson T, Cantley LC
J Biol Chem. 1995
PubMed ID: 7592796
-
Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestation.
Bidwell MC, Eitzman BA, Walmer DK, McLachlan JA, Gray KD
Endocrinology. 1995
PubMed ID: 7588258
-
Identification of a putative Syp substrate, the PDGF beta receptor.
Klinghoffer RA, Kazlauskas A
J Biol Chem. 1995
PubMed ID: 7545675
-
Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes.
Shafqat S, Velaz-Faircloth M, Henzi VA, Whitney KD, Yang-Feng TL, Seldin MF, Fremeau RT
Mol Pharmacol. 1995
PubMed ID: 7651355
-
The chemotactic response to PDGF-BB: evidence of a role for Ras.
Kundra V, Anand-Apte B, Feig LA, Zetter BR
J Cell Biol. 1995
PubMed ID: 7622571
-
Murine txk: a protein tyrosine kinase gene regulated by T cell activation.
Sommers CL, Huang K, Shores EW, Grinberg A, Charlick DA, Kozak CA, Love PE
Oncogene. 1995
PubMed ID: 7542761
-
Coordinate regulation by diethylstilbestrol of the platelet-derived growth factor-A (PDGF-A) and -B chains and the PDGF receptor alpha- and beta-subunits in the mouse uterus and vagina: potential mediators of estrogen action.
Gray K, Eitzman B, Raszmann K, Steed T, Geboff A, McLachlan J, Bidwell M
Endocrinology. 1995
PubMed ID: 7720681
-
Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.
Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M
Oncogene. 1995
PubMed ID: 7537362
-
Construction of an SH2 domain-binding site with mixed specificity.
Larose L, Gish G, Pawson T
J Biol Chem. 1995
PubMed ID: 7876130
-
The distribution of PDGFs and PDGF-receptors during murine secondary palate development.
Qiu CX, Ferguson MW
J Anat. 1995
PubMed ID: 7649812
-
Mapping of the genes for four members of the transmembrane 4 superfamily: mouse Cd9, Cd63, Cd81, and Cd82.
Seldin MF, Rochelle JM, Tomlinson MG, Wright MD
Immunogenetics. 1995
PubMed ID: 7590978
-
Platelet-derived growth factor receptor signals.
Claesson-Welsh L
J Biol Chem. 1994
PubMed ID: 7798193
-
Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome.
Goldstein C, Liaw P, Jimenez SA, Buchberg AM, Siracusa LD
Mamm Genome. 1994
PubMed ID: 7873879
-
Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation.
Arvidsson AK, Rupp E, Nånberg E, Downward J, Rönnstrand L, Wennström S, Schlessinger J, Heldin CH, Claesson-Welsh L
Mol Cell Biol. 1994
PubMed ID: 7935391
-
A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex.
Rupp E, Siegbahn A, Rönnstrand L, Wernstedt C, Claesson-Welsh L, Heldin CH
Eur J Biochem. 1994
PubMed ID: 7523122
-
Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.
Soriano P
Genes Dev. 1994
PubMed ID: 7958864
-
Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.
Bennett AM, Tang TL, Sugimoto S, Walsh CT, Neel BG
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8041791
-
Platelet-derived growth factor (PDGF) induction of egr-1 is independent of PDGF receptor autophosphorylation on tyrosine.
Mundschau LJ, Forman LW, Weng H, Faller DV
J Biol Chem. 1994
PubMed ID: 8206913
-
Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp.
Feng GS, Shen R, Heng HH, Tsui LC, Kazlauskas A, Pawson T
Oncogene. 1994
PubMed ID: 8183548
-
Direct interaction between Shc and the platelet-derived growth factor beta-receptor.
Yokote K, Mori S, Hansen K, McGlade J, Pawson T, Heldin CH, Claesson-Welsh L
J Biol Chem. 1994
PubMed ID: 8195171
-
Expression of the platelet-derived growth factor beta receptor during organogenesis and tissue differentiation in the mouse embryo.
Shinbrot E, Peters KG, Williams LT
Dev Dyn. 1994
PubMed ID: 8018985
-
Regulation of chemotaxis by the platelet-derived growth factor receptor-beta.
Kundra V, Escobedo JA, Kazlauskas A, Kim HK, Rhee SG, Williams LT, Zetter BR
Nature. 1994
PubMed ID: 8107807
-
Platelet-derived growth factor (PDGF) receptors in the developing mouse optic pathway.
Hutchins JB, Zhang X
Vis Neurosci. 1994
PubMed ID: 8011581
-
Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.
Kozlowski M, Mlinaric-Rascan I, Feng GS, Shen R, Pawson T, Siminovitch KA
J Exp Med. 1993
PubMed ID: 8245788
-
Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors.
Wilkie TM, Chen Y, Gilbert DJ, Moore KJ, Yu L, Simon MI, Copeland NG, Jenkins NA
Genomics. 1993
PubMed ID: 8288218
-
Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.
Nishimura R, Li W, Kashishian A, Mondino A, Zhou M, Cooper J, Schlessinger J
Mol Cell Biol. 1993
PubMed ID: 7692233
-
Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.
Lechleider RJ, Sugimoto S, Bennett AM, Kashishian AS, Cooper JA, Shoelson SE, Walsh CT, Neel BG
J Biol Chem. 1993
PubMed ID: 7691811
-
Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1.
Larose L, Gish G, Shoelson S, Pawson T
Oncogene. 1993
PubMed ID: 7689724
-
The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion.
McGlade J, Brunkhorst B, Anderson D, Mbamalu G, Settleman J, Dedhar S, Rozakis-Adcock M, Chen LB, Pawson T
EMBO J. 1993
PubMed ID: 8344248
-
Platelet-derived growth factor induces proliferation of hyperplastic human prostatic stromal cells.
Vlahos CJ, Kriauciunas TD, Gleason PE, Jones JA, Eble JN, Salvas D, Falcone JF, Hirsch KS
J Cell Biochem. 1993
PubMed ID: 7693727
-
The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.
Kazlauskas A, Feng GS, Pawson T, Valius M
Proc Natl Acad Sci U S A. 1993
PubMed ID: 7688466
-
Conservation in sequence and affinity of human and rodent PDGF ligands and receptors.
Herren B, Weyer KA, Rouge M, Lötscher P, Pech M
Biochim Biophys Acta. 1993
PubMed ID: 8318539
-
Successive activation of the platelet-derived growth factor beta receptor and platelet-derived growth factor B genes correlates with the genesis of human choriocarcinoma.
Holmgren L, Flam F, Larsson E, Ohlsson R
Cancer Res. 1993
PubMed ID: 8504434
-
Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach.
Panayotou G, Gish G, End P, Truong O, Gout I, Dhand R, Fry MJ, Hiles I, Pawson T, Waterfield MD
Mol Cell Biol. 1993
PubMed ID: 8388538
-
Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.
Mori S, Rönnstrand L, Yokote K, Engström A, Courtneidge SA, Claesson-Welsh L, Heldin CH
EMBO J. 1993
PubMed ID: 7685273
-
SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases.
Feng GS, Hui CC, Pawson T
Science. 1993
PubMed ID: 8096088
-
Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor.
Fretto LJ, Snape AJ, Tomlinson JE, Seroogy JJ, Wolf DL, LaRochelle WJ, Giese NA
J Biol Chem. 1993
PubMed ID: 7679113
-
Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1.
Kashishian A, Cooper JA
Mol Biol Cell. 1993
PubMed ID: 8443409
-
Assignment of 22 loci in the rat by somatic hybrid and linkage analysis.
Yeung RS, Hino O, Vilensky M, Buetow K, Szpirer C, Szpirer J, Klinga-Levan K, Levan G, Knudson AG
Mamm Genome. 1993
PubMed ID: 8268657
-
The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors.
Li W, Hu P, Skolnik EY, Ullrich A, Schlessinger J
Mol Cell Biol. 1992
PubMed ID: 1333047
-
Identification of residues in GTPase-activating protein Src homology 2 domains that control binding to tyrosine phosphorylated growth factor receptors and p62.
Marengere LE, Pawson T
J Biol Chem. 1992
PubMed ID: 1385407
-
Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma.
Rönnstrand L, Mori S, Arridsson AK, Eriksson A, Wernstedt C, Hellman U, Claesson-Welsh L, Heldin CH
EMBO J. 1992
PubMed ID: 1396585
-
A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18.
Justice MJ, Gilbert DJ, Kinzler KW, Vogelstein B, Buchberg AM, Ceci JD, Matsuda Y, Chapman VM, Patriotis C, Makris A
Genomics. 1992
PubMed ID: 1354644
-
A multipoint genetic linkage map of mouse chromosome 18.
Johnson KR, Davisson MT
Genomics. 1992
PubMed ID: 1354640
-
Developmental distribution of platelet-derived growth factor in the mouse central nervous system.
Hutchins JB, Jefferson VE
Brain Res Dev Brain Res. 1992
PubMed ID: 1324805
-
GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.
Kazlauskas A, Kashishian A, Cooper JA, Valius M
Mol Cell Biol. 1992
PubMed ID: 1375321
-
Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways.
Fantl WJ, Escobedo JA, Martin GA, Turck CW, del Rosario M, McCormick F, Williams LT
Cell. 1992
PubMed ID: 1374684
-
Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo.
Kashishian A, Kazlauskas A, Cooper JA
EMBO J. 1992
PubMed ID: 1314164
-
Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor.
Mori S, Heldin CH, Claesson-Welsh L
J Biol Chem. 1992
PubMed ID: 1313434
-
SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors.
McGlade CJ, Ellis C, Reedijk M, Anderson D, Mbamalu G, Reith AD, Panayotou G, End P, Bernstein A, Kazlauskas A
Mol Cell Biol. 1992
PubMed ID: 1372092
-
Genes encoding the platelet-derived growth factor (PDGF) receptor and colony-stimulating factor 1 (CSF-1) receptor are physically associated in mice as in humans.
Eccles MR
Gene. 1991
PubMed ID: 1660841
-
Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.
Holtrich U, Bräuninger A, Strebhardt K, Rübsamen-Waigmann H
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1720539
-
Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution.
Oakey RJ, Caron MG, Lefkowitz RJ, Seldin MF
Genomics. 1991
PubMed ID: 1676978
-
Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit.
Kazlauskas A, Durden DL, Cooper JA
Cell Regul. 1991
PubMed ID: 1653029
-
Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation.
Kelly JD, Haldeman BA, Grant FJ, Murray MJ, Seifert RA, Bowen-Pope DF, Cooper JA, Kazlauskas A
J Biol Chem. 1991
PubMed ID: 1709159
-
Ligand-induced interaction between alpha- and beta-type platelet-derived growth factor (PDGF) receptors: role of receptor heterodimers in kinase activation.
Kanakaraj P, Raj S, Khan SA, Bishayee S
Biochemistry. 1991
PubMed ID: 1847074
-
Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor.
Sorkin A, Westermark B, Heldin CH, Claesson-Welsh L
J Cell Biol. 1991
PubMed ID: 1846866
-
Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors.
Anderson D, Koch CA, Grey L, Ellis C, Moran MF, Pawson T
Science. 1990
PubMed ID: 2173144
-
Association between the PDGF receptor and members of the src family of tyrosine kinases.
Kypta RM, Goldberg Y, Ulug ET, Courtneidge SA
Cell. 1990
PubMed ID: 1696179
-
Platelet-derived growth factor receptor: current views of the two-subunit model.
Hart CE, Bowen-Pope DF
J Invest Dermatol. 1990
PubMed ID: 2161888
-
Binding of GAP to activated PDGF receptors.
Kazlauskas A, Ellis C, Pawson T, Cooper JA
Science. 1990
PubMed ID: 2157284
-
Selective expression of PDGF A and its receptor during early mouse embryogenesis.
Mercola M, Wang CY, Kelly J, Brownlee C, Jackson-Grusby L, Stiles C, Bowen-Pope D
Dev Biol. 1990
PubMed ID: 2155144
-
An efficient directional cloning system to construct cDNA libraries containing full-length inserts at high frequency.
Miki T, Matsui T, Heidaran MA, Aaronson SA
Gene. 1989
PubMed ID: 2531695
-
Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways.
Matsui T, Pierce JH, Fleming TP, Greenberger JS, LaRochelle WJ, Ruggiero M, Aaronson SA
Proc Natl Acad Sci U S A. 1989
PubMed ID: 2554309
-
Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins.
Kazlauskas A, Cooper JA
Cell. 1989
PubMed ID: 2550144
-
Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor.
Morrison DK, Kaplan DR, Escobedo JA, Rapp UR, Roberts TM, Williams LT
Cell. 1989
PubMed ID: 2475255
-
Genes for beta 2-adrenergic receptor and platelet-derived growth factor receptor map to mouse chromosome 18.
Sundaresan S, Francke U
Somat Cell Mol Genet. 1989
PubMed ID: 2569767
-
Two different subunits associate to create isoform-specific platelet-derived growth factor receptors.
Seifert RA, Hart CE, Phillips PE, Forstrom JW, Ross R, Murray MJ, Bowen-Pope DF
J Biol Chem. 1989
PubMed ID: 2542288
-
A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human.
Buchberg AM, Brownell E, Nagata S, Jenkins NA, Copeland NG
Genetics. 1989
PubMed ID: 2567264
-
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes.
Matsui T, Heidaran M, Miki T, Popescu N, La Rochelle W, Kraus M, Pierce J, Aaronson S
Science. 1989
PubMed ID: 2536956
-
Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes.
Roberts WM, Look AT, Roussel MF, Sherr CJ
Cell. 1988
PubMed ID: 2846185
-
cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules.
Claesson-Welsh L, Eriksson A, Morén A, Severinsson L, Ek B, Ostman A, Betsholtz C, Heldin CH
Mol Cell Biol. 1988
PubMed ID: 2850496
-
Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.
Gronwald RG, Grant FJ, Haldeman BA, Hart CE, O'Hara PJ, Hagen FS, Ross R, Bowen-Pope DF, Murray MJ
Proc Natl Acad Sci U S A. 1988
PubMed ID: 2835772
-
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors.
Yarden Y, Escobedo JA, Kuang WJ, Yang-Feng TL, Daniel TO, Tremble PM, Chen EY, Ando ME, Harkins RN, Francke U
Nature. 1986
PubMed ID: 3020426
-
Chromosomal mapping of genes involved in growth control.
Francke U, Yang-Feng TL, Brissenden JE, Ullrich A
Cold Spring Harb Symp Quant Biol. 1986
PubMed ID: 3107886
Model Organism Phenotype Links
|
Relevant resources: