PAFAH1B1

Summary Top Help

Gene Description:

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); platelet-activating factor acetylhydrolase, isoform 1b, subunit 1

Synonyms:

LIS2, MMS10-U, Mdsh, PAFAH, MDS, Ms10u, MDCR, PAFAH1B1, LIS1, Lis1, LIS-1, Pafah1b1, Pafaha

Orthologs:

Human PAFAH1B1 (protein-coding), Mouse Pafah1b1 (protein-coding), Rat Pafah1b1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr17:2496923..2588909 (91.99 kb) View in Genome Browser

(Mouse) NCBIM37 - chr11:74487451..74538172 (50.72 kb) View in Genome Browser

(Rat) RGSC3.4 - chr10:61955348..62037871 (82.52 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PAFAH1B1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PAFAH1B1:

The PAFAH1B1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
PAFAH1B1	EDIL3	IntAct, BioGRID	empirical	20360068
PAFAH1B1	ACTR1A	Reactome	predicted	12852856
PAFAH1B1	AKAP9	Reactome	predicted	12852856
PAFAH1B1	TUBB4A	Reactome	predicted	12852856
PAFAH1B1	TUBB4B	Reactome	predicted	12852856
PAFAH1B1	DCTN2	BioGRID, Reactome	empirical	11889140 12852856
PAFAH1B1	CENPA	Reactome	predicted
PAFAH1B1	CENPE	Reactome	predicted
PAFAH1B1	CENPF	IntAct, Reactome	empirical	15939891 17600710
PAFAH1B1	CETN2	Reactome	predicted	12852856
PAFAH1B1	NUDC	HPRD, IntAct, BioGRID, Reactome	empirical	9601647 11734602 11163258
PAFAH1B1	PLK4	Reactome	predicted	12852856
PAFAH1B1	SDCCAG8	Reactome	predicted	12852856
PAFAH1B1	HSPH1	HPRD	empirical	14733918
PAFAH1B1	KIF2C	Reactome	predicted
PAFAH1B1	CNTRL	Reactome	predicted	12852856
PAFAH1B1	WDR5	BioGRID	empirical	17041588
PAFAH1B1	FGFR1OP	Reactome	predicted	12852856
PAFAH1B1	ZWINT	Reactome	predicted
PAFAH1B1	CEP250	Reactome	predicted	12852856
PAFAH1B1	DCTN3	Reactome	predicted	12852856
PAFAH1B1	NEDD1	Reactome	predicted	12852856
PAFAH1B1	CSNK1D	Reactome	predicted	12852856
PAFAH1B1	CSNK1E	Reactome	predicted	12852856
PAFAH1B1	CSNK2A1	HPRD, BioGRID	empirical	10491172
PAFAH1B1	SGOL2	Reactome	predicted
PAFAH1B1	SGOL1	Reactome	predicted
PAFAH1B1	DAB1	HPRD	empirical	14578885
PAFAH1B1	DCTN1	HPRD, BioGRID, Reactome	empirical	14584027 11889140 12852856
PAFAH1B1	DCX	HPRD, BioGRID	empirical	11001923
PAFAH1B1	PPP1R18	IntAct, BioGRID	empirical	20360068
PAFAH1B1	DYNC1H1	BioGRID, Reactome	empirical	11889140 12852856
PAFAH1B1	DYNC1I2	Reactome	predicted	12852856
PAFAH1B1	SKA1	Reactome	predicted
PAFAH1B1	CEP164	Reactome	predicted	12852856
PAFAH1B1	MAPRE1	Reactome	predicted	12852856
PAFAH1B1	NINL	Reactome	predicted	12852856
PAFAH1B1	AZI1	Reactome	predicted	12852856
PAFAH1B1	CEP152	Reactome	predicted	12852856
PAFAH1B1	TNIK	BioGRID	empirical	17043677
PAFAH1B1	CLASP2	Reactome	predicted
PAFAH1B1	CLASP1	Reactome	predicted	12852856
PAFAH1B1	AHCTF1	Reactome	predicted
PAFAH1B1	DNAI1	HPRD	empirical	11889140
PAFAH1B1	DISC1	IntAct, BioGRID	empirical	90000000 17043677
PAFAH1B1	TMOD3	IntAct, BioGRID	empirical	20360068
PAFAH1B1	HSP90AA1	Reactome	predicted	12852856
PAFAH1B1	INCENP	Reactome	predicted
PAFAH1B1	KARS	HPRD, MINT, IntAct, BioGRID	empirical	16169070
PAFAH1B1	KIF2A	Reactome	predicted
PAFAH1B1	MAP1B	HPRD	empirical	15762842
PAFAH1B1	NEK2	Reactome	predicted	12852856
PAFAH1B1	ODF2	Reactome	predicted	12852856
PAFAH1B1	PAFAH1B1	HPRD, IntAct, BioGRID	empirical	11889140 20360068
PAFAH1B1	PAFAH1B2	HPRD, IntAct, BioGRID	empirical	10727864 20360068
PAFAH1B1	PAFAH1B3	HPRD, IntAct, BioGRID	empirical	10727864 11231056 20360068
PAFAH1B1	PCM1	Reactome	predicted	12852856
PAFAH1B1	PCNT	Reactome	predicted	12852856
PAFAH1B1	PLK1	Reactome	predicted	12852856
PAFAH1B1	PLS3	IntAct, BioGRID	empirical	20360068
PAFAH1B1	NDE1	HPRD, IntAct, BioGRID, Reactome	empirical	11163258 20360068 12852856
PAFAH1B1	ERCC6L	Reactome	predicted
PAFAH1B1	CCDC99	Reactome	predicted
PAFAH1B1	PPP1CA	IntAct, BioGRID	empirical	20360068
PAFAH1B1	PPP1CC	Reactome	predicted
PAFAH1B1	CEP192	Reactome	predicted	12852856
PAFAH1B1	HAUS2	Reactome	predicted	12852856
PAFAH1B1	PPP2R1A	Reactome	predicted	12852856
PAFAH1B1	PRKACA	Reactome	predicted	12852856
PAFAH1B1	CEP72	Reactome	predicted	12852856
PAFAH1B1	CDK5RAP2	Reactome	predicted	12852856
PAFAH1B1	PRKAR2B	Reactome	predicted	12852856
PAFAH1B1	CENPJ	Reactome	predicted	12852856
PAFAH1B1	RCC2	Reactome	predicted
PAFAH1B1	TAOK1	Reactome	predicted
PAFAH1B1	RANBP2	Reactome	predicted
PAFAH1B1	RANGAP1	Reactome	predicted
PAFAH1B1	RPS27	Reactome	predicted
PAFAH1B1	CLIP1	HPRD, BioGRID, Reactome	empirical	11940666
PAFAH1B1	SLC2A4	IntAct	empirical	16396496
PAFAH1B1	FSCN1	IntAct	empirical	20360068
PAFAH1B1	BUB1	Reactome	predicted
PAFAH1B1	TPM2	IntAct	empirical	20360068
PAFAH1B1	TUBA4A	Reactome	predicted	12852856
PAFAH1B1	TUBG1	Reactome	predicted	12852856
PAFAH1B1	UBC	BioGRID	empirical	18781797 21139048 21906983
PAFAH1B1	XPO1	Reactome	predicted
PAFAH1B1	YWHAG	Reactome	predicted	12852856
PAFAH1B1	ALMS1	Reactome	predicted	12852856
PAFAH1B1	TUBA1A	HPRD, BioGRID, Reactome	empirical	9384577 12852856
PAFAH1B1	CEP76	Reactome	predicted	12852856
PAFAH1B1	CALD1	IntAct, BioGRID	empirical	20360068
PAFAH1B1	CEP290	Reactome	predicted	12852856
PAFAH1B1	CEP63	Reactome	predicted	12852856
PAFAH1B1	CEP70	Reactome	predicted	12852856
PAFAH1B1	B9D2	Reactome	predicted
PAFAH1B1	NDEL1	HPRD, IntAct, BioGRID, Reactome	empirical	11163260 11231056 10931877 20360068 12796778
PAFAH1B1	KIF18A	Reactome	predicted
PAFAH1B1	CAPZA2	IntAct	empirical	20360068
PAFAH1B1	MAD1L1	Reactome	predicted
PAFAH1B1	CEP78	Reactome	predicted	12852856
PAFAH1B1	KIF2B	Reactome	predicted
PAFAH1B1	OFD1	Reactome	predicted	12852856
PAFAH1B1	SSNA1	Reactome	predicted	12852856
PAFAH1B1	DYNLL1	Reactome	predicted	12852856
PAFAH1B1	CEP41	Reactome	predicted	12852856
PAFAH1B1	IQCB1	IntAct	empirical	21565611
PAFAH1B1	CEP135	Reactome	predicted	12852856
PAFAH1B1	CEP57	Reactome	predicted	12852856
PAFAH1B1	CCP110	Reactome	predicted	12852856
PAFAH1B1	CKAP5	Reactome	predicted	12852856
PAFAH1B1	SFI1	Reactome	predicted	12852856
PAFAH1B1	CDK1	Reactome	predicted	12852856
PAFAH1B1	CDC20	Reactome	predicted

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 2

Biocarta: 1

Reactome: 11

NCI-Nature Pathway Interaction Database: 2

Gene Ontology: 73

Publications from PubMed Top Help

Type 1 Diabetes Publications: 2

Publications: 224

No association of polymorphisms in the CDK5, NDEL1, and LIS1 with autism in Chinese Han population.
Wang L, Li J, Jia M, Yue W, Ruan Y, Lu T, Zhang J, Liu J, Zhang D
Psychiatry Res. 2011
PubMed ID: 21890215
A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons.
Pandey JP, Smith DS
J Neurosci. 2011
PubMed ID: 22114287
Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin.
McKenney RJ, Weil SJ, Scherer J, Vallee RB
J Biol Chem. 2011
PubMed ID: 21911489
High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport.
Yi JY, Ori-McKenney KM, McKenney RJ, Vershinin M, Gross SP, Vallee RB
J Cell Biol. 2011
PubMed ID: 22006948
Three-dimensional regulation of radial glial functions by Lis1-Nde1 and dystrophin glycoprotein complexes.
Pawlisz AS, Feng Y
PLoS Biol. 2011
PubMed ID: 22028625
Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis.
Sumigray KD, Chen H, Lechler T
J Cell Biol. 2011
PubMed ID: 21844209
Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.
Murdoch H, Vadrevu S, Prinz A, Dunlop AJ, Klussmann E, Bolger GB, Norman JC, Houslay MD
J Cell Sci. 2011
PubMed ID: 21652625
The phospholipase A₂ enzyme complex PAFAH Ib mediates endosomal membrane tubule formation and trafficking.
Bechler ME, Doody AM, Ha KD, Judson BL, Chen I, Brown WJ
Mol Biol Cell. 2011
PubMed ID: 21593204
Focusing forward genetics: a tripartite ENU screen for neurodevelopmental mutations in the mouse.
Stottmann RW, Moran JL, Turbe-Doan A, Driver E, Kelley M, Beier DR
Genetics. 2011
PubMed ID: 21515572
The human LIS1 is downregulated in hepatocellular carcinoma and plays a tumor suppressor function.
Xing Z, Tang X, Gao Y, Da L, Song H, Wang S, Tiollais P, Li T, Zhao M
Biochem Biophys Res Commun. 2011
PubMed ID: 21569763
Regulation of lung endoderm progenitor cell behavior by miR302/367.
Tian Y, Zhang Y, Hurd L, Hannenhalli S, Liu F, Lu MM, Morrisey EE
Development. 2011
PubMed ID: 21350014
Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects.
Pramparo T, Libiger O, Jain S, Li H, Youn YH, Hirotsune S, Schork NJ, Wynshaw-Boris A
PLoS Genet. 2011
PubMed ID: 21423666
Peripheral administration of bovine GH regulates the expression of cerebrocortical beta-globin, GABAB receptor 1, and the Lissencephaly-1 protein (LIS-1) in adult hypophysectomized rats.
Walser M, Hansén A, Svensson PA, Jernås M, Oscarsson J, Isgaard J, Åberg ND
Growth Horm IGF Res. 2011
PubMed ID: 21212011
A new case of duplication of the MDS region identified by high-density SNP arrays and a review of the literature.
Faletra F, Devescovi R, Pecile V, Fabretto A, Carrozzi M, Gasparini P
J Appl Genet. 2011
PubMed ID: 21107783
Functional dissection of LIS1 and NDEL1 towards understanding the molecular mechanisms of cytoplasmic dynein regulation.
Torisawa T, Nakayama A, Furuta K, Yamada M, Hirotsune S, Toyoshima YY
J Biol Chem. 2011
PubMed ID: 21036906
Overexpression of Lis1 in different stages of spermatogenesis does not result in an aberrant phenotype.
Drusenheimer N, Nayernia K, Meinhardt A, Jung B, Arnold HH, Engel W
Cytogenet Genome Res. 2011
PubMed ID: 21734362
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migration.
Hippenmeyer S, Youn YH, Moon HM, Miyamichi K, Zong H, Wynshaw-Boris A, Luo L
Neuron. 2010
PubMed ID: 21092859
A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).
Romero R, Friel LA, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Erez O, Chaiworapongsa T, Pearce BD, Bartlett J, Salisbury BA, Anant MK, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R
Am J Obstet Gynecol. 2010
PubMed ID: 20673868
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability.
Zhu XJ, Liu X, Jin Q, Cai Y, Yang Y, Zhou T
J Biol Chem. 2010
PubMed ID: 20675372
Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis.
Lu J, Pierce M, Franklin A, Jilling T, Stafforini DM, Caplan M
Pediatr Res. 2010
PubMed ID: 20531249
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.
Singh KK, Ge X, Mao Y, Drane L, Meletis K, Samuels BA, Tsai LH
Neuron. 2010
PubMed ID: 20624590
Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling.
Yano M, Hayakawa-Yano Y, Mele A, Darnell RB
Neuron. 2010
PubMed ID: 20620871
Leading process branch instability in Lis1+/- nonradially migrating interneurons.
Gopal PP, Simonet JC, Shapiro W, Golden JA
Cereb Cortex. 2010
PubMed ID: 19861636
Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.
Romero R, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Chaiworapongsa T, Pearce BD, Friel LA, Bartlett J, Anant MK, Salisbury BA, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R
Am J Obstet Gynecol. 2010
PubMed ID: 20452482
The exon junction complex component Magoh controls brain size by regulating neural stem cell division.
Silver DL, Watkins-Chow DE, Schreck KC, Pierfelice TJ, Larson DM, Burnetti AJ, Liaw HJ, Myung K, Walsh CA, Gaiano N, Pavan WJ
Nat Neurosci. 2010
PubMed ID: 20364144
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
Study of association between genetic polymorphisms of phospholipase A2 enzymes and Alzheimer's disease.
Cordeiro Q, Noguti R, Bottino CM, Vallada H
Arq Neuropsiquiatr. 2010
PubMed ID: 20464283
The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogensis.
Yamada M, Hirotsune S, Wynshaw-Boris A
Cell Adh Migr. 2010
PubMed ID: 20168084
Novel embryonic neuronal migration and proliferation defects in Dcx mutant mice are exacerbated by Lis1 reduction.
Pramparo T, Youn YH, Yingling J, Hirotsune S, Wynshaw-Boris A
J Neurosci. 2010
PubMed ID: 20181597
NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90.
Yang Y, Yan X, Cai Y, Lu Y, Si J, Zhou T
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133715
Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging.
Nicodemus KK, Callicott JH, Higier RG, Luna A, Nixon DC, Lipska BK, Vakkalanka R, Giegling I, Rujescu D, Clair DS, Muglia P, Shugart YY, Weinberger DR
Hum Genet. 2010
PubMed ID: 20084519
Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning.
Lam C, Vergnolle MA, Thorpe L, Woodman PG, Allan VJ
J Cell Sci. 2010
PubMed ID: 20048338
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC
PLoS One. 2010
PubMed ID: 20634891
Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.
Ryckman KK, Morken NH, White MJ, Velez DR, Menon R, Fortunato SJ, Magnus P, Williams SM, Jacobsson B
PLoS One. 2010
PubMed ID: 20140262
Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice.
Youn YH, Pramparo T, Hirotsune S, Wynshaw-Boris A
J Neurosci. 2009
PubMed ID: 20007476
Seizures, enhanced excitation, and increased vesicle number in Lis1 mutant mice.
Greenwood JS, Wang Y, Estrada RC, Ackerman L, Ohara PT, Baraban SC
Ann Neurol. 2009
PubMed ID: 19938147
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.
Zhang X, Lei K, Yuan X, Wu X, Zhuang Y, Xu T, Xu R, Han M
Neuron. 2009
PubMed ID: 19874786
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.
Yamada M, Yoshida Y, Mori D, Takitoh T, Kengaku M, Umeshima H, Takao K, Miyakawa T, Sato M, Sorimachi H, Wynshaw-Boris A, Hirotsune S
Nat Med. 2009
PubMed ID: 19734909
Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia.
Rastogi A, Zai C, Likhodi O, Kennedy JL, Wong AH
Schizophr Res. 2009
PubMed ID: 19632097
Opposing effects of Ndel1 and alpha1 or alpha2 on cytoplasmic dynein through competitive binding to Lis1.
Ding C, Liang X, Ma L, Yuan X, Zhu X
J Cell Sci. 2009
PubMed ID: 19622634
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
LIS1-related isolated lissencephaly: spectrum of mutations and relationships with malformation severity.
Saillour Y, Carion N, Quelin C, Leger PL, Boddaert N, Elie C, Toutain A, Mercier S, Barthez MA, Milh M, Joriot S, des Portes V, Philip N, Broglin D, Roubertie A, Pitelet G, Moutard ML, Pinard JM, Cances C, Kaminska A, Chelly J, Beldjord C, Bahi-Buisson N
Arch Neurol. 2009
PubMed ID: 19667223
Inhibitory inputs to hippocampal interneurons are reorganized in Lis1 mutant mice.
Jones DL, Baraban SC
J Neurophysiol. 2009
PubMed ID: 19515951
Intragenic deletions and duplications of the LIS1 and DCX genes: a major disease-causing mechanism in lissencephaly and subcortical band heterotopia.
Haverfield EV, Whited AJ, Petras KS, Dobyns WB, Das S
Eur J Hum Genet. 2009
PubMed ID: 19050731
Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.
Tomppo L, Hennah W, Lahermo P, Loukola A, Tuulio-Henriksson A, Suvisaari J, Partonen T, Ekelund J, Lönnqvist J, Peltonen L
Biol Psychiatry. 2009
PubMed ID: 19251251
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Increased LIS1 expression affects human and mouse brain development.
Bi W, Sapir T, Shchelochkov OA, Zhang F, Withers MA, Hunter JV, Levy T, Shinder V, Peiffer DA, Gunderson KL, Nezarati MM, Shotts VA, Amato SS, Savage SK, Harris DJ, Day-Salvatore DL, Horner M, Lu XY, Sahoo T, Yanagawa Y, Beaudet AL, Cheung SW, Martinez S, Lupski JR, Reiner O
Nat Genet. 2009
PubMed ID: 19136950
Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.
Velez DR, Fortunato S, Thorsen P, Lombardi SJ, Williams SM, Menon R
Am J Obstet Gynecol. 2009
PubMed ID: 19019335
If Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.
Menon R, Pearce B, Velez DR, Merialdi M, Williams SM, Fortunato SJ, Thorsen P
Reprod Biol Endocrinol. 2009
PubMed ID: 19527514
Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly.
Tanenbaum ME, Macůrek L, Galjart N, Medema RH
EMBO J. 2008
PubMed ID: 19020519
LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein.
Yamada M, Toba S, Yoshida Y, Haratani K, Mori D, Yano Y, Mimori-Kiyosue Y, Nakamura T, Itoh K, Fushiki S, Setou M, Wynshaw-Boris A, Torisawa T, Toyoshima YY, Hirotsune S
EMBO J. 2008
PubMed ID: 18784752
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells.
Hebbar S, Mesngon MT, Guillotte AM, Desai B, Ayala R, Smith DS
J Cell Biol. 2008
PubMed ID: 18809722
Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination.
Pawlisz AS, Mutch C, Wynshaw-Boris A, Chenn A, Walsh CA, Feng Y
Hum Mol Genet. 2008
PubMed ID: 18469343
Pafah1b2 mutations suppress the development of hydrocephalus in compound Pafah1b1; Reln and Pafah1b1; Dab1 mutant mice.
Assadi AH, Zhang G, McNeil R, Clark GD, D'Arcangelo G
Neurosci Lett. 2008
PubMed ID: 18514414
Identification of a domain that mediates association of platelet-activating factor acetylhydrolase with high density lipoprotein.
Gardner AA, Reichert EC, Topham MK, Stafforini DM
J Biol Chem. 2008
PubMed ID: 18434304
High frequency of genomic deletions--and a duplication--in the LIS1 gene in lissencephaly: implications for molecular diagnosis.
Mei D, Lewis R, Parrini E, Lazarou LP, Marini C, Pilz DT, Guerrini R
J Med Genet. 2008
PubMed ID: 18285425
[Molecular mechanism of lissencephaly: how LIS1 regulates cytoplasmic dynein]
Hirotsune S
No To Hattatsu. 2008
PubMed ID: 18524253
Platelet activating factor-acetylhydrolase (PAF-AH) activity and HDL levels, but not PAF-AH gene polymorphisms, are associated with successful aging in Sicilian octogenarians.
Campo S, Sardo MA, Trimarchi G, Bonaiuto A, Saitta C, Bitto A, Castaldo M, Cinquegrani M, Bonaiuto M, Cristadoro S, Saitta A
Aging Clin Exp Res. 2008
PubMed ID: 18431085
[Molecular mechanism of lissencephaly--how LIS1 and NDEL1 regulate cytoplasmic dynein?]
Hirotsune S
Brain Nerve. 2008
PubMed ID: 18421979
Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells.
Shen Y, Li N, Wu S, Zhou Y, Shan Y, Zhang Q, Ding C, Yuan Q, Zhao F, Zeng R, Zhu X
Dev Cell. 2008
PubMed ID: 18331715
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division.
Yingling J, Youn YH, Darling D, Toyo-Oka K, Pramparo T, Hirotsune S, Wynshaw-Boris A
Cell. 2008
PubMed ID: 18267077
Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.
Velez DR, Fortunato SJ, Thorsen P, Lombardi SJ, Williams SM, Menon R
PLoS ONE. 2008
PubMed ID: 18818748
Aberrant dentate gyrus cytoarchitecture and fiber lamination in Lis1 mutant mice.
Wang Y, Baraban SC
Hippocampus. 2008
PubMed ID: 18446829
Genetic enhancement of the Lis1+/- phenotype by a heterozygous mutation in the adenomatous polyposis coli gene.
Hebbar S, Guillotte AM, Mesngon MT, Zhou Q, Wynshaw-Boris A, Smith DS
Dev Neurosci. 2008
PubMed ID: 18075263
The role of DCX and LIS1 in migration through the lateral cortical stream of developing forebrain.
Bai J, Ramos RL, Paramasivam M, Siddiqi F, Ackman JB, LoTurco JJ
Dev Neurosci. 2008
PubMed ID: 18075262
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
Ballif BA, Carey GR, Sunyaev SR, Gygi SP
J Proteome Res. 2008
PubMed ID: 18034455
Characterization of inhibitory circuits in the malformed hippocampus of Lis1 mutant mice.
Jones DL, Baraban SC
J Neurophysiol. 2007
PubMed ID: 17881479
Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.
Tang LY, Deng N, Wang LS, Dai J, Wang ZL, Jiang XS, Li SJ, Li L, Sheng QH, Wu DQ, Li L, Zeng R
Mol Cell Proteomics. 2007
PubMed ID: 17693683
Type I platelet-activating factor acetylhydrolase catalytic subunits over-expression induces pleiomorphic nuclei and centrosome amplification.
Yamaguchi N, Koizumi H, Aoki J, Natori Y, Nishikawa K, Natori Y, Takanezawa Y, Arai H
Genes Cells. 2007
PubMed ID: 17903175
Lissencephaly and LIS1: insights into the molecular mechanisms of neuronal migration and development.
Wynshaw-Boris A
Clin Genet. 2007
PubMed ID: 17850624
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissue.
Tsai JW, Bremner KH, Vallee RB
Nat Neurosci. 2007
PubMed ID: 17618279
Location and type of mutation in the LIS1 gene do not predict phenotypic severity.
Uyanik G, Morris-Rosendahl DJ, Stiegler J, Klapecki J, Gross C, Berman Y, Martin P, Dey L, Spranger S, Korenke GC, Schreyer I, Hertzberg C, Neumann TE, Burkart P, Spaich C, Meng M, Holthausen H, Adès L, Seidel J, Mangold E, Buyse G, Meinecke P, Schara U, Zeschnigk C, Muller D, Helland G, Schulze B, Wright ML, Kortge-Jung S, Hehr A, Bogdahn U, Schuierer G, Kohlhase J, Aigner L, Wolff G, Hehr U, Winkler J
Neurology. 2007
PubMed ID: 17664403
PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation.
Pletnikov MV, Xu Y, Ovanesov MV, Kamiya A, Sawa A, Ross CA
Neurosci Res. 2007
PubMed ID: 17418909
Isolation and characterization of nudC from mouse macrophages, a gene implicated in the inflammatory response through the regulation of PAF-AH(I) activity.
Riera J, Rodríguez R, Carcedo MT, Campa VM, Ramos S, Lazo PS
FEBS Lett. 2007
PubMed ID: 17555748
Postnatal alterations of the inhibitory synaptic responses recorded from cortical pyramidal neurons in the Lis1/sLis1 mutant mouse.
Valdés-Sánchez L, Escámez T, Echevarria D, Ballesta JJ, Tabarés-Seisdedos R, Reiner O, Martinez S, Geijo-Barrientos E
Mol Cell Neurosci. 2007
PubMed ID: 17433713
Cytoplasmic dynein and LIS1 are required for microtubule advance during growth cone remodeling and fast axonal outgrowth.
Grabham PW, Seale GE, Bennecib M, Goldberg DJ, Vallee RB
J Neurosci. 2007
PubMed ID: 17522326
The lissencephaly protein Lis1 is present in motile mammalian cilia and requires outer arm dynein for targeting to Chlamydomonas flagella.
Pedersen LB, Rompolas P, Christensen ST, Rosenbaum JL, King SM
J Cell Sci. 2007
PubMed ID: 17314247
Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.
Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC
Atherosclerosis. 2007
PubMed ID: 16806233
DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1.
Taya S, Shinoda T, Tsuboi D, Asaki J, Nagai K, Hikita T, Kuroda S, Kuroda K, Shimizu M, Hirotsune S, Iwamatsu A, Kaibuchi K
J Neurosci. 2007
PubMed ID: 17202468
The full-ORF clone resource of the German cDNA Consortium.
Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blöcker H, Heubner D, Hoerlein A, Michel G, Wedler H, Köhrer K, Ottenwälder B, Poustka A, Wiemann S, Schupp I
BMC Genomics. 2007
PubMed ID: 17974005
The Pafah1b complex interacts with the Reelin receptor VLDLR.
Zhang G, Assadi AH, McNeil RS, Beffert U, Wynshaw-Boris A, Herz J, Clark GD, D'Arcangelo G
PLoS ONE. 2007
PubMed ID: 17330141
Granule cell dispersion and aberrant neurogenesis in the adult hippocampus of an LIS1 mutant mouse.
Wang Y, Baraban SC
Dev Neurosci. 2007
PubMed ID: 17148952
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.
Camargo LM, Collura V, Rain JC, Mizuguchi K, Hermjakob H, Kerrien S, Bonnert TP, Whiting PJ, Brandon NJ
Mol Psychiatry. 2007
PubMed ID: 17043677
CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.
Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H
Nat Cell Biol. 2006
PubMed ID: 17041588
Paraoxonase 1 gene polymorphisms influence clinical features of open-angle glaucoma.
Inagaki Y, Mashima Y, Funayama T, Ohtake Y, Fuse N, Yasuda N, Fukuchi T, Murakami A, Hotta Y
Graefes Arch Clin Exp Ophthalmol. 2006
PubMed ID: 16411107
Impaired proliferation and migration in human Miller-Dieker neural precursors.
Sheen VL, Ferland RJ, Harney M, Hill RS, Neal J, Banham AH, Brown P, Chenn A, Corbo J, Hecht J, Folkerth R, Walsh CA
Ann Neurol. 2006
PubMed ID: 16642511
Association of platelet-activating factor acetylhydrolase gene polymorphism with premature coronary artery disease in Turkish patients.
Sekuri C, Cam FS, Tengiz I, Ercan E, Bayturan O, Berdeli A
Anadolu Kardiyol Derg. 2006
PubMed ID: 16766276
[Correlation between desmin gene, platelet-activating factor acetylhydrolase gene and dilated cardiomyopathy]
Wang B, Rao L, Zhang L, Zhou B, Wang YP, Chen XY
Sichuan Da Xue Xue Bao Yi Xue Ban. 2006
PubMed ID: 16761416
Platelet-activating factor-acetylhydrolase A379V (exon 11) gene polymorphism is an independent and functional risk factor for premature myocardial infarction.
Liu PY, Li YH, Wu HL, Chao TH, Tsai LM, Lin LJ, Shi GY, Chen JH
J Thromb Haemost. 2006
PubMed ID: 16689754
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C
Nature. 2006
PubMed ID: 16625196
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.
Petretti C, Savoian M, Montembault E, Glover DM, Prigent C, Giet R
EMBO Rep. 2006
PubMed ID: 16462731
The dimerization mechanism of LIS1 and its implication for proteins containing the LisH motif.
Mateja A, Cierpicki T, Paduch M, Derewenda ZS, Otlewski J
J Mol Biol. 2006
PubMed ID: 16445939
Regulation of cytoplasmic dynein ATPase by Lis1.
Mesngon MT, Tarricone C, Hebbar S, Guillotte AM, Schmitt EW, Lanier L, Musacchio A, King SJ, Smith DS
J Neurosci. 2006
PubMed ID: 16481446
Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly.
Guo J, Yang Z, Song W, Chen Q, Wang F, Zhang Q, Zhu X
Mol Biol Cell. 2006
PubMed ID: 16291865
Inhibition of PP2A by LIS1 increases HIV-1 gene expression.
Epie N, Ammosova T, Turner W, Nekhai S
Retrovirology. 2006
PubMed ID: 17018134
Variations in genes regulating neuronal migration predict reduced prefrontal cognition in schizophrenia and bipolar subjects from mediterranean Spain: a preliminary study.
Tabarés-Seisdedos R, Escámez T, Martínez-Giménez JA, Balanzá V, Salazar J, Selva G, Rubio C, Vieta E, Geijó-Barrientos E, Martínez-Arán A, Reiner O, Martínez S
Neuroscience. 2006
PubMed ID: 16549273
Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility.
Kholmanskikh SS, Koeller HB, Wynshaw-Boris A, Gomez T, Letourneau PC, Ross ME
Nat Neurosci. 2006
PubMed ID: 16369480
Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization.
Gerlitz G, Darhin E, Giorgio G, Franco B, Reiner O
Cell Cycle. 2005
PubMed ID: 16258276
Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.
Toyo-Oka K, Sasaki S, Yano Y, Mori D, Kobayashi T, Toyoshima YY, Tokuoka SM, Ishii S, Shimizu T, Muramatsu M, Hiraiwa N, Yoshiki A, Wynshaw-Boris A, Hirotsune S
Hum Mol Genet. 2005
PubMed ID: 16203747
Temporal and spatial transcriptional programs in murine kidney development.
Challen G, Gardiner B, Caruana G, Kostoulias X, Martinez G, Crowe M, Taylor DF, Bertram J, Little M, Grimmond SM
Physiol Genomics. 2005
PubMed ID: 15998744
Poliovirus protein 3A binds and inactivates LIS1, causing block of membrane protein trafficking and deregulation of cell division.
Kondratova AA, Neznanov N, Kondratov RV, Gudkov AV
Cell Cycle. 2005
PubMed ID: 16138011
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor.
Kihara Y, Ishii S, Kita Y, Toda A, Shimada A, Shimizu T
J Exp Med. 2005
PubMed ID: 16172262
LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages.
Tsai JW, Chen Y, Kriegstein AR, Vallee RB
J Cell Biol. 2005
PubMed ID: 16144905
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality.
Sasaki S, Mori D, Toyo-oka K, Chen A, Garrett-Beal L, Muramatsu M, Miyagawa S, Hiraiwa N, Yoshiki A, Wynshaw-Boris A, Hirotsune S
Mol Cell Biol. 2005
PubMed ID: 16107726
[Analysis of 994(G--> T) mutation in the plasma platelet-activating factor acetylhydrolase gene in the patients with cerebral infarction]
Zhang X, Yuan CL, Zhang HZ, Xu J, Wu J, Chen BL
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005
PubMed ID: 16086290
Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1.
Jiménez-Mateos EM, Wandosell F, Reiner O, Avila J, González-Billault C
Biochem J. 2005
PubMed ID: 15762842
A polymorphism in plasma platelet-activating factor acetylhydrolase is involved in resistance to immunoglobulin treatment in Kawasaki disease.
Minami T, Suzuki H, Takeuchi T, Uemura S, Sugatani J, Yoshikawa N
J Pediatr. 2005
PubMed ID: 16027700
Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway.
Soukoulis V, Reddy S, Pooley RD, Feng Y, Walsh CA, Bader DM
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15939891
HIV-1 Tat interacts with LIS1 protein.
Epie N, Ammosova T, Sapir T, Voloshin Y, Lane WS, Turner W, Reiner O, Nekhai S
Retrovirology. 2005
PubMed ID: 15698475
Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase.
Tarricone C, Perrina F, Monzani S, Massimiliano L, Kim MH, Derewenda ZS, Knapp S, Tsai LH, Musacchio A
Neuron. 2004
PubMed ID: 15572112
Mitotic spindle regulation by Nde1 controls cerebral cortical size.
Feng Y, Walsh CA
Neuron. 2004
PubMed ID: 15473967
Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning.
Shu T, Ayala R, Nguyen MD, Xie Z, Gleeson JG, Tsai LH
Neuron. 2004
PubMed ID: 15473966
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Lis1 is necessary for normal non-radial migration of inhibitory interneurons.
McManus MF, Nasrallah IM, Pancoast MM, Wynshaw-Boris A, Golden JA
Am J Pathol. 2004
PubMed ID: 15331402
Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration.
Tanaka T, Serneo FF, Higgins C, Gambello MJ, Wynshaw-Boris A, Gleeson JG
J Cell Biol. 2004
PubMed ID: 15173193
The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications.
Kim MH, Cooper DR, Oleksy A, Devedjiev Y, Derewenda U, Reiner O, Otlewski J, Derewenda ZS
Structure. 2004
PubMed ID: 15274919
Expression of NUDEL in manchette and its implication in spermatogenesis.
Yamaguchi N, Takanezawa Y, Koizumi H, Umezu-Goto M, Aoki J, Arai H
FEBS Lett. 2004
PubMed ID: 15147871
Platelet-activating factor acetylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis.
Osoegawa M, Niino M, Ochi H, Kikuchi S, Murai H, Fukazawa T, Minohara M, Tashiro K, Kira J
J Neuroimmunol. 2004
PubMed ID: 15081260
Neocortical neuronal arrangement in LIS1 and DCX lissencephaly may be different.
Viot G, Sonigo P, Simon I, Simon-Bouy B, Chadeyron F, Beldjord C, Tantau J, Martinovic J, Esculpavit C, Brunelle F, Munnich A, Vekemans M, Encha-Razavi F
Am J Med Genet A. 2004
PubMed ID: 15057976
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
Mutation screening in a cohort of patients with lissencephaly and subcortical band heterotopia.
Torres FR, Montenegro MA, Marques-De-Faria AP, Guerreiro MM, Cendes F, Lopes-Cendes I
Neurology. 2004
PubMed ID: 15007136
Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein.
Liang Y, Yu W, Li Y, Yang Z, Yan X, Huang Q, Zhu X
J Cell Biol. 2004
PubMed ID: 14970193
Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems.
Saito Y, Doi K, Yamagishi N, Ishihara K, Hatayama T
Biochem Biophys Res Commun. 2004
PubMed ID: 14733918
Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.
Brandon NJ, Handford EJ, Schurov I, Rain JC, Pelling M, Duran-Jimeniz B, Camargo LM, Oliver KR, Beher D, Shearman MS, Whiting PJ
Mol Cell Neurosci. 2004
PubMed ID: 14962739
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
A role for cytoplasmic dynein and LIS1 in directed cell movement.
Dujardin DL, Barnhart LE, Stehman SA, Gomes ER, Gundersen GG, Vallee RB
J Cell Biol. 2003
PubMed ID: 14691133
LIS1 association with dynactin is required for nuclear motility and genomic union in the fertilized mammalian oocyte.
Payne C, St John JC, Ramalho-Santos J, Schatten G
Cell Motil Cytoskeleton. 2003
PubMed ID: 14584027
Inactivation of a testis-specific Lis1 transcript in mice prevents spermatid differentiation and causes male infertility.
Nayernia K, Vauti F, Meinhardt A, Cadenas C, Schweyer S, Meyer BI, Schwandt I, Chowdhury K, Engel W, Arnold HH
J Biol Chem. 2003
PubMed ID: 13129914
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Interaction of reelin signaling and Lis1 in brain development.
Assadi AH, Zhang G, Beffert U, McNeil RS, Renfro AL, Niu S, Quattrocchi CC, Antalffy BA, Sheldon M, Armstrong DD, Wynshaw-Boris A, Herz J, D'Arcangelo G, Clark GD
Nat Genet. 2003
PubMed ID: 14578885
Mosaic mutations of the LIS1 gene cause subcortical band heterotopia.
Sicca F, Kelemen A, Genton P, Das S, Mei D, Moro F, Dobyns WB, Guerrini R
Neurology. 2003
PubMed ID: 14581661
LIS1 missense mutations: variable phenotypes result from unpredictable alterations in biochemical and cellular properties.
Caspi M, Coquelle FM, Koifman C, Levy T, Arai H, Aoki J, De Mey JR, Reiner O
J Biol Chem. 2003
PubMed ID: 12885786
A study of the nature of embryonic lethality in LIS1-/- mice.
Cahana A, Jin XL, Reiner O, Wynshaw-Boris A, O'Neill C
Mol Reprod Dev. 2003
PubMed ID: 12950100
Disregulated RhoGTPases and actin cytoskeleton contribute to the migration defect in Lis1-deficient neurons.
Kholmanskikh SS, Dobrin JS, Wynshaw-Boris A, Letourneau PC, Ross ME
J Neurosci. 2003
PubMed ID: 14507966
Miller-Dieker syndrome: analysis of a human contiguous gene syndrome in the mouse.
Yingling J, Toyo-Oka K, Wynshaw-Boris A
Am J Hum Genet. 2003
PubMed ID: 12905154
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Involvement of platelet-activating factor and LIS1 in neuronal migration.
Tokuoka SM, Ishii S, Kawamura N, Satoh M, Shimada A, Sasaki S, Hirotsune S, Wynshaw-Boris A, Shimizu T
Eur J Neurosci. 2003
PubMed ID: 12911752
Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.
Casenghi M, Meraldi P, Weinhart U, Duncan PI, Körner R, Nigg EA
Dev Cell. 2003
PubMed ID: 12852856
14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome.
Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A
Nat Genet. 2003
PubMed ID: 12796778
Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis.
Yan W, Assadi AH, Wynshaw-Boris A, Eichele G, Matzuk MM, Clark GD
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12775763
Targeted disruption of intracellular type I platelet activating factor-acetylhydrolase catalytic subunits causes severe impairment in spermatogenesis.
Koizumi H, Yamaguchi N, Hattori M, Ishikawa TO, Aoki J, Taketo MM, Inoue K, Arai H
J Biol Chem. 2003
PubMed ID: 12551946
Multiple dose-dependent effects of Lis1 on cerebral cortical development.
Gambello MJ, Darling DL, Yingling J, Tanaka T, Gleeson JG, Wynshaw-Boris A
J Neurosci. 2003
PubMed ID: 12629176
Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.
Yan X, Li F, Liang Y, Shen Y, Zhao X, Huang Q, Zhu X
Mol Cell Biol. 2003
PubMed ID: 12556484
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Differential expression of platelet-activating factor acetylhydrolase in macrophages and monocyte-derived dendritic cells.
Al-Darmaki S, Schenkein HA, Tew JG, Barbour SE
J Immunol. 2003
PubMed ID: 12496397
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover.
de Haan G, Bystrykh LV, Weersing E, Dontje B, Geiger H, Ivanova N, Lemischka IR, Vellenga E, Van Zant G
Blood. 2002
PubMed ID: 12200366
Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.
Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y
Mol Biol Cell. 2002
PubMed ID: 12221128
Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons.
Sugitani Y, Nakai S, Minowa O, Nishi M, Jishage K, Kawano H, Mori K, Ogawa M, Noda T
Genes Dev. 2002
PubMed ID: 12130536
Single nucleotide polymorphism (G994-->T) in the plasma platelet-activating factor-acetylhydrolase gene is associated with graft patency of femoropopliteal bypass.
Unno N, Nakamura T, Mitsuoka H, Saito T, Miki K, Ishimaru K, Sugatani J, Miwa M, Nakamura S
Surgery. 2002
PubMed ID: 12110797
LIS1, CLIP-170's key to the dynein/dynactin pathway.
Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O
Mol Cell Biol. 2002
PubMed ID: 11940666
Laminar disorganisation of mitral cells in the olfactory bulb does not affect topographic targeting of primary olfactory axons.
Royal SJ, Gambello MJ, Wynshaw-Boris A, Key B, Clarris HJ
Brain Res. 2002
PubMed ID: 11911856
Epileptogenic brain malformations: clinical presentation, malformative patterns and indications for genetic testing.
Guerrini R, Carrozzo R
Seizure. 2002
PubMed ID: 12185771
Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function.
Tai CY, Dujardin DL, Faulkner NE, Vallee RB
J Cell Biol. 2002
PubMed ID: 11889140
Evidence for an association between plasma platelet-activating factor acetylhydrolase deficiency and increased risk of childhood atopic asthma.
Ito S, Noguchi E, Shibasaki M, Yamakawa-Kobayashi K, Watanabe H, Arinami T
J Hum Genet. 2002
PubMed ID: 11916011
LIS1-no more no less.
Reiner O, Cahana A, Escamez T, Martinez S
Mol Psychiatry. 2002
PubMed ID: 11803439
NudC associates with Lis1 and the dynein motor at the leading pole of neurons.
Aumais JP, Tunstead JR, McNeil RS, Schaar BT, McConnell SK, Lin SH, Clark GD, Yu-Lee LY
J Neurosci. 2001
PubMed ID: 11734602
LIS1 missense mutations cause milder lissencephaly phenotypes including a child with normal IQ.
Leventer RJ, Cardoso C, Ledbetter DH, Dobyns WB
Neurology. 2001
PubMed ID: 11502906
Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization.
Cahana A, Escamez T, Nowakowski RS, Hayes NL, Giacobini M, von Holst A, Shmueli O, Sapir T, McConnell SK, Wurst W, Martinez S, Reiner O
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11344260
Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme.
Min JH, Wilder C, Aoki J, Arai H, Inoue K, Paul L, Gelb MH
Biochemistry. 2001
PubMed ID: 11294621
NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins.
Sweeney KJ, Prokscha A, Eichele G
Mech Dev. 2001
PubMed ID: 11231056
The effects of aging on gene expression in the hypothalamus and cortex of mice.
Jiang CH, Tsien JZ, Schultz PG, Hu Y
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11172053
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Length of uninterrupted repeats determines instability at the unstable mouse expanded simple tandem repeat family MMS10 derived from independent SINE B1 elements.
Bois PR, Southgate L, Jeffreys AJ
Mamm Genome. 2001
PubMed ID: 11210178
In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice.
Stojanov T, O'Neill C
Biol Reprod. 2001
PubMed ID: 11159375
NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein.
Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai LH
Neuron. 2000
PubMed ID: 11163260
A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system.
Sasaki S, Shionoya A, Ishida M, Gambello MJ, Yingling J, Wynshaw-Boris A, Hirotsune S
Neuron. 2000
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LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome.
Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA
Neuron. 2000
PubMed ID: 11163258
The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion.
Mayor T, Stierhof YD, Tanaka K, Fry AM, Nigg EA
J Cell Biol. 2000
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
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A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function.
Faulkner NE, Dujardin DL, Tai CY, Vaughan KT, O'Connell CB, Wang Y, Vallee RB
Nat Cell Biol. 2000
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Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1.
Smith DS, Niethammer M, Ayala R, Zhou Y, Gambello MJ, Wynshaw-Boris A, Tsai LH
Nat Cell Biol. 2000
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
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Interaction between LIS1 and doublecortin, two lissencephaly gene products.
Caspi M, Atlas R, Kantor A, Sapir T, Reiner O
Hum Mol Genet. 2000
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Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Hippocampal abnormalities and enhanced excitability in a murine model of human lissencephaly.
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J Neurosci. 2000
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Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development.
Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G
Mech Dev. 2000
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LIS1 is a microtubule-associated phosphoprotein.
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Eur J Biochem. 1999
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Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice.
Paylor R, Hirotsune S, Gambello MJ, Yuva-Paylor L, Crawley JN, Wynshaw-Boris A
Learn Mem. 1999
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Subcortical band heterotopia in rare affected males can be caused by missense mutations in DCX (XLIS) or LIS1.
Pilz DT, Kuc J, Matsumoto N, Bodurtha J, Bernadi B, Tassinari CA, Dobyns WB, Ledbetter DH
Hum Mol Genet. 1999
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Cortical malformations and epilepsy: new insights from animal models.
Chevassus-au-Louis N, Baraban SC, Gaïarsa JL, Ben-Ari Y
Epilepsia. 1999
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Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration.
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J Lipid Res. 1999
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LIS1 and platelet-activating factor acetylhydrolase (Ib) catalytic subunits, expression in the mouse oocyte and zygote.
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FEBS Lett. 1999
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Ontogeny of expression of a receptor for platelet-activating factor in mouse preimplantation embryos and the effects of fertilization and culture in vitro on its expression.
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Biol Reprod. 1999
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality.
Hirotsune S, Fleck MW, Gambello MJ, Bix GJ, Chen A, Clark GD, Ledbetter DH, McBain CJ, Wynshaw-Boris A
Nat Genet. 1998
PubMed ID: 9697693
Switching of platelet-activating factor acetylhydrolase catalytic subunits in developing rat brain.
Manya H, Aoki J, Watanabe M, Adachi T, Asou H, Inoue Y, Arai H, Inoue K
J Biol Chem. 1998
PubMed ID: 9660828
The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC.
Morris SM, Albrecht U, Reiner O, Eichele G, Yu-Lee LY
Curr Biol. 1998
PubMed ID: 9601647
Roles of plasma platelet-activating factor acetylhydrolase in allergic, inflammatory, and atherosclerotic diseases.
Yamada Y, Yokota M
Jpn Circ J. 1998
PubMed ID: 9626899
Expression of a 45K subunit of platelet-activating factor acetylhydrolase in the developing mouse cerebellum.
Isumi H, Takashima S, Ikeda K, Mizuguchi M
Anat Embryol (Berl). 1998
PubMed ID: 9623676
Cloning and characterization of cDNAs and the gene encoding the mouse platelet-activating factor acetylhydrolase Ib alpha subunit/lissencephaly-1 protein.
Péterfy M, Gyuris T, Grosshans D, Cuaresma CC, Takács L
Genomics. 1998
PubMed ID: 9479492
Molecular cloning of cDNAs encoding alpha1, alpha2, and beta subunits of rat brain platelet-activating factor acetylhydrolase.
Watanabe M, Aoki J, Manya H, Arai H, Inoue K
Biochim Biophys Acta. 1998
PubMed ID: 9459487
Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit.
Sapir T, Elbaum M, Reiner O
EMBO J. 1997
PubMed ID: 9384577
Platelet-activating factor acetylhydrolases.
Stafforini DM, McIntyre TM, Zimmerman GA, Prescott SM
J Biol Chem. 1997
PubMed ID: 9218411
Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human region.
Hirotsune S, Pack SD, Chong SS, Robbins CM, Pavan WJ, Ledbetter DH, Wynshaw-Boris A
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Point mutations and an intragenic deletion in LIS1, the lissencephaly causative gene in isolated lissencephaly sequence and Miller-Dieker syndrome.
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Hum Mol Genet. 1997
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Expression of the LIS-1 gene product in brain anomalies with a migration disorder.
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Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor.
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Localization of the mouse lissencephaly-1 gene to mouse chromosome 11B3, in close proximity to D11Mit65.
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Somat Cell Mol Genet. 1995
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Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.
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J Cell Biol. 1995
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Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration.
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J Neurosci. 1995
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The mouse homolog of the human Miller-Dieker chromosomal region (MDCR) maps to mouse chromosome 11 in close proximity to Mov9 and D11Nds1.
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Mamm Genome. 1995
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Lissencephaly-1 is one of the most conserved proteins between mouse and human: a single amino-acid difference in 410 residues.
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Gene. 1994
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Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected]
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Nature. 1994
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Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats.
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Nature. 1993
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[A rare case of ileo-ileal intussusception secondary to adenocarcinoma of the small intestine in a 21-year-old adult].
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Molecular dissection of a contiguous gene syndrome: frequent submicroscopic deletions, evolutionarily conserved sequences, and a hypomethylated "island" in the Miller-Dieker chromosome region.
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Proc Natl Acad Sci U S A. 1989
PubMed ID: 2740347

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	5048	18472	83572
EnsEMBL Gene(s)	ENSG00000007168	ENSMUSG00000020745	ENSRNOG00000002755
Unigene	Hs.77318	Mm.397111	Rn.5827
Homologene	PAFAH1B1	Pafah1b1	Pafah1b1
OMIM	601545	N/A	N/A
GeneCards	PAFAH1B1	N/A	N/A
Beta Cell Genomics	DT.100844382 DT.100893741 DT.448229 DT.95198247 DT.95265403	DT.101187575 DT.110538071 DT.40173322 DT.534770 DT.94157948 DT.97357823	N/A
Reactome	P43034	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	5048	18472	83572

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