OAT

Summary Top Help

Gene Description:

ornithine aminotransferase

Synonyms:

rOAT, OKT, Oat, OATASE, OAT, GACR, AI194874, HOGA

Orthologs:

Human OAT (protein-coding), Mouse Oat (protein-coding), Rat Oat (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1 Rat: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Not assigned	Mouse	chr7:117936155..152524553	34.59	508

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm10	Rat	chr1:178054386..201472944	23.42	321

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr10:126085872..126107545 (21.67 kb) View in Genome Browser

(Mouse) NCBIM37 - chr7:139749158..139768081 (18.92 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:192026623..192046404 (19.78 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for OAT:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for OAT:

The OAT interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
OAT	HDAC5	BioGRID	empirical	21081666
OAT	EIF1B	IntAct	empirical	17353931
OAT	SSSCA1	IntAct	empirical	17353931
OAT	PTP4A3	IntAct	empirical	17353931
OAT	NUDT3	BioGRID	empirical	21900206
OAT	NAGS	Sanger Interaction Map	predicted	15345047
OAT	DMWD	IntAct, BioGRID	empirical	19615732
OAT	HLA-B	IntAct	empirical	17353931
OAT	ICT1	BioGRID	empirical	20186120
OAT	APP	IntAct	empirical	17934213
OAT	EIF6	IntAct	empirical	17353931
OAT	KCNMA1	IntAct	empirical	19423573
OAT	ARF6	IntAct	empirical	17353931
OAT	MCC	IntAct	empirical	17353931
OAT	MYC	IntAct, BioGRID	empirical	17314511
OAT	OAT	HPRD	empirical	2363680 7932736 9309222 9514741 9878407
OAT	OTC	Sanger Interaction Map	predicted	15345047
OAT	OTUD4	IntAct, BioGRID	empirical	19615732
OAT	C2orf18	HPRD, MINT, IntAct, BioGRID	empirical	16169070
OAT	PRKAB1	IntAct	empirical	17353931
OAT	UBQLN4	HPRD, MINT, IntAct	empirical	16713569
OAT	SLC2A4	IntAct	empirical	16396496
OAT	TRAF6	IntAct	empirical	17353931
OAT	UBC	BioGRID	empirical	17623298 21139048 21890473 21906983
OAT	MAP1LC3A	IntAct	empirical	20562859
OAT	SGPL1	Sanger Interaction Map	predicted	15345047
OAT	CCNA1	IntAct	empirical	17353931

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 2

Biocarta: 1

Reactome: 2

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 11

Publications from PubMed Top Help

Publications: 83

A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Differential proteomics leads to identification of domain-specific epididymal sperm proteins.
Suryawanshi AR, Khan SA, Gajbhiye RK, Gurav MY, Khole VV
J Androl. 2011
PubMed ID: 20966424
Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
Greco TM, Yu F, Guise AJ, Cristea IM
Mol Cell Proteomics. 2011
PubMed ID: 21081666
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Adaptative response of nitrogen metabolism in early endotoxemia: role of ornithine aminotransferase.
Ventura G, Moinard C, Segaud F, Le Plenier S, Cynober L, De Bandt JP
Amino Acids. 2010
PubMed ID: 20549270
Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH
Pharmacogenomics. 2010
PubMed ID: 20602615
A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome.
Richter R, Rorbach J, Pajak A, Smith PM, Wessels HJ, Huynen MA, Smeitink JA, Lightowlers RN, Chrzanowska-Lightowlers ZM
EMBO J. 2010
PubMed ID: 20186120
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PLoS One. 2010
PubMed ID: 20877624
Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
A mitochondrial protein compendium elucidates complex I disease biology.
Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK
Cell. 2008
PubMed ID: 18614015
A proteomic approach towards the Hsp90-dependent ubiquitinylated proteome.
Falsone SF, Gesslbauer B, Rek A, Kungl AJ
Proteomics. 2007
PubMed ID: 17623298
Sex-differential expression of ornithine aminotransferase in the mouse kidney.
Levillain O, Ventura G, Déchaud H, Hobeika M, Meseguer A, Moinard C, Cynober L
Am J Physiol Renal Physiol. 2007
PubMed ID: 17341717
Hepatic HNF4alpha deficiency induces periportal expression of glutamine synthetase and other pericentral enzymes.
Stanulović VS, Kyrmizi I, Kruithof-de Julio M, Hoogenkamp M, Vermeulen JL, Ruijter JM, Talianidis I, Hakvoort TB, Lamers WH
Hepatology. 2007
PubMed ID: 17256722
Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.
Koch HB, Zhang R, Verdoodt B, Bailey A, Zhang CD, Yates JR, Menssen A, Hermeking H
Cell Cycle. 2007
PubMed ID: 17314511
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY
Cell. 2006
PubMed ID: 16713569
Determinants of substrate specificity in omega-aminotransferases.
Markova M, Peneff C, Hewlins MJ, Schirmer T, John RA
J Biol Chem. 2005
PubMed ID: 16096275
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Testosterone down-regulates ornithine aminotransferase gene and up-regulates arginase II and ornithine decarboxylase genes for polyamines synthesis in the murine kidney.
Levillain O, Diaz JJ, Blanchard O, Déchaud H
Endocrinology. 2005
PubMed ID: 15539552
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
The DNA sequence and comparative analysis of human chromosome 10.
Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J
Nature. 2004
PubMed ID: 15164054
Ornithine metabolism in male and female rat kidney: mitochondrial expression of ornithine aminotransferase and arginase II.
Levillain O, Hus-Citharel A, Garvi S, Peyrol S, Reymond I, Mutin M, Morel F
Am J Physiol Renal Physiol. 2004
PubMed ID: 14871882
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell. 2003
PubMed ID: 14651853
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
The mouse Nkx-1.2 homeobox gene: alternative RNA splicing at canonical and noncanonical splice sites.
Rovescalli AC, Cinquanta M, Ferrante J, Kozak CA, Nirenberg M
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10681422
Correction of ornithine accumulation prevents retinal degeneration in a mouse model of gyrate atrophy of the choroid and retina.
Wang T, Steel G, Milam AH, Valle D
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10655512
Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine.
Storici P, Capitani G, Müller R, Schirmer T, Jansonius JN
J Mol Biol. 1999
PubMed ID: 9878407
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Crystal structure of human recombinant ornithine aminotransferase.
Shen BW, Hennig M, Hohenester E, Jansonius JN, Schirmer T
J Mol Biol. 1998
PubMed ID: 9514741
Human ornithine aminotransferase complexed with L-canaline and gabaculine: structural basis for substrate recognition.
Shah SA, Shen BW, Brünger AT
Structure. 1997
PubMed ID: 9309222
A mouse model of gyrate atrophy of the choroid and retina. Early retinal pigment epithelium damage and progressive retinal degeneration.
Wang T, Milam AH, Steel G, Valle D
J Clin Invest. 1996
PubMed ID: 8675686
The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26.
Elson A, Kozak CA, Morton CC, Weremowicz S, Leder P
Genomics. 1996
PubMed ID: 8838320
Mouse gastric mucin: cloning and chromosomal localization.
Shekels LL, Lyftogt C, Kieliszewski M, Filie JD, Kozak CA, Ho SB
Biochem J. 1995
PubMed ID: 7487932
Epithelial sodium channel genes Scnn1b and Scnn1g are closely linked on distal mouse chromosome 7.
Brooker DR, Kozak CA, Kleyman TR
Genomics. 1995
PubMed ID: 8575777
Mice lacking ornithine-delta-aminotransferase have paradoxical neonatal hypoornithinaemia and retinal degeneration.
Wang T, Lawler AM, Steel G, Sipila I, Milam AH, Valle D
Nat Genet. 1995
PubMed ID: 7550347
Sequence of the promoter region of the mouse gene encoding ornithine aminotransferase.
Shull JD, Esumi N, Colwell AS, Pennington KL, Jendoubi M
Gene. 1995
PubMed ID: 7557443
A single amino acid substitution within the mature sequence of ornithine aminotransferase obstructs mitochondrial entry of the precursor.
Kobayashi T, Ogawa H, Kasahara M, Shiozawa Z, Matsuzawa T
Am J Hum Genet. 1995
PubMed ID: 7668253
Cell-type specific interactions between retinoic acid and thyroid hormone in the regulation of expression of the gene encoding ornithine aminotransferase.
Shull JD, Pennington KL, Gurr JA, Ross AC
Endocrinology. 1995
PubMed ID: 7720661
Uroporphyrinogen-III synthase: molecular cloning, nucleotide sequence, expression of a mouse full-length cDNA, and its localization on mouse chromosome 7.
Xu W, Kozak CA, Desnick RJ
Genomics. 1995
PubMed ID: 7607680
Rat phenol-preferring sulfotransferase genes (Stp and Stp2): localization to mouse chromosomes 7 and 17.
Khan AS, Taylor BR, Filie JD, Ringer DP, Kozak CA
Genomics. 1995
PubMed ID: 7601475
Pyridoxine-responsive gyrate atrophy of the choroid and retina: clinical and biochemical correlates of the mutation A226V.
Michaud J, Thompson GN, Brody LC, Steel G, Obie C, Fontaine G, Schappert K, Keith CG, Valle D, Mitchell GA
Am J Hum Genet. 1995
PubMed ID: 7887415
Arginine and ornithine metabolizing enzymes in testosterone-induced hypertrophic mouse kidney.
Manteuffel-Cymborowska M, Chmurzyńska W, Peska M, Grzelakowska-Sztabert B
Int J Biochem Cell Biol. 1995
PubMed ID: 7780833
Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1).
Kozak CA, Gatignol A, Graham K, Jeang KT, McBride OW
Genomics. 1995
PubMed ID: 7774957
Crystallization and preliminary X-ray diffraction studies of recombinant human ornithine aminotransferase.
Shen BW, Ramesh V, Mueller R, Hohenester E, Hennig M, Jansonius JN
J Mol Biol. 1994
PubMed ID: 7932736
Decreased hyperammonaemia and orotic aciduria due to inactivation of ornithine aminotransferase in mice with a hereditary abnormal ornithine carbamoyltransferase.
Seiler N, Grauffel C, Daune-Anglard G, Sarhan S, Knödgen B
J Inherit Metab Dis. 1994
PubMed ID: 7707692
Genetic mapping of three GABAA receptor-subunit genes in the mouse.
Danciger M, Farber DB, Kozak CA
Genomics. 1993
PubMed ID: 8390964
Promoter region of the rat gene encoding ornithine aminotransferase: transcriptional activity, sequence, and DNase-I-hypersensitive sites.
Shull JD, Pennington KL, Rader AE
Gene. 1993
PubMed ID: 8462871
Mouse liver protein database: a catalog of proteins detected by two-dimensional gel electrophoresis.
Giometti CS, Taylor J, Tollaksen SL
Electrophoresis. 1992
PubMed ID: 1286668
Isolation and characterization of the rat gene encoding ornithine aminotransferase.
Shull JD, Pennington KL, Pitot HC, Boryca VS, Schulte BL
Biochim Biophys Acta. 1992
PubMed ID: 1390894
A deletion in the ornithine aminotransferase gene in gyrate atrophy.
Akaki Y, Hotta Y, Mashima Y, Murakami A, Kennaway NG, Weleber RG, Inana G
J Biol Chem. 1992
PubMed ID: 1618792
Strand-separating conformational polymorphism analysis: efficacy of detection of point mutations in the human ornithine delta-aminotransferase gene.
Michaud J, Brody LC, Steel G, Fontaine G, Martin LS, Valle D, Mitchell G
Genomics. 1992
PubMed ID: 1612597
Ornithine delta-aminotransferase mutations in gyrate atrophy. Allelic heterogeneity and functional consequences.
Brody LC, Mitchell GA, Obie C, Michaud J, Steel G, Fontaine G, Robert MF, Sipila I, Kaiser-Kupfer M, Valle D
J Biol Chem. 1992
PubMed ID: 1737786
Mapping of ornithine aminotransferase gene sequences to mouse chromosomes 7, X, and 3.
Ramesh V, Cheng SV, Kozak CA, Herron BJ, Shih VE, Taylor BA, Gusella JF
Mamm Genome. 1992
PubMed ID: 1349842
The ornithine aminotransferase-encoding gene family of rat: cloning, characterization, and evolutionary relationships between a single expressed gene and three pseudogenes.
Shull JD, Pennington KL, George SM, Kilibarda KA
Gene. 1991
PubMed ID: 1916291
Molecular pathology of gyrate atrophy of the choroid and retina due to ornithine aminotransferase deficiency.
Ramesh V, Gusella JF, Shih VE
Mol Biol Med. 1991
PubMed ID: 1682785
Mapping HSA10 homologous loci in cattle.
Threadgill DS, Womack JE
Cytogenet Cell Genet. 1991
PubMed ID: 1655359
Complete amino acid sequence of rat kidney ornithine aminotransferase: identity with liver ornithine aminotransferase.
Oyama R, Suzuki M, Matsuzawa T, Titani K
J Biochem. 1990
PubMed ID: 2229004
Analysis of the human ornithine aminotransferase gene family.
Zintz CB, Inana G
Exp Eye Res. 1990
PubMed ID: 2373169
DL-canaline and 5-fluoromethylornithine. Comparison of two inactivators of ornithine aminotransferase.
Bolkenius FN, Knödgen B, Seiler N
Biochem J. 1990
PubMed ID: 2363680
Point mutation affecting processing of the ornithine aminotransferase precursor protein in gyrate atrophy.
Inana G, Chambers C, Hotta Y, Inouye L, Filpula D, Pulford S, Shiono T
J Biol Chem. 1989
PubMed ID: 2793865
Molecular cloning and nucleotide sequence analysis of mRNA for human kidney ornithine aminotransferase. An examination of ornithine aminotransferase isozymes between liver and kidney.
Kobayashi T, Nishii M, Takagi Y, Titani K, Matsuzawa T
FEBS Lett. 1989
PubMed ID: 2507357
Gyrate atrophy of the choroid and retina: assignment of the ornithine aminotransferase structural gene to human chromosome 10 and mouse chromosome 7.
O'Donnell JJ, Vannas-Sulonen K, Shows TB, Cox DR
Am J Hum Genet. 1988
PubMed ID: 3195589
A heritable variant of mouse liver ornithine aminotransferase (EC 2.6.1.13) induced by ethylnitrosourea.
Giometti CS, Tollaksen SL, Gemmell MA, Burcham J, Peraino C
J Biol Chem. 1988
PubMed ID: 3170611
Human ornithine-delta-aminotransferase. cDNA cloning and analysis of the structural gene.
Mitchell GA, Looney JE, Brody LC, Steel G, Suchanek M, Engelhardt JF, Willard HF, Valle D
J Biol Chem. 1988
PubMed ID: 3170546
Molecular basis of ornithine aminotransferase deficiency in B-6-responsive and -nonresponsive forms of gyrate atrophy.
Ramesh V, McClatchey AI, Ramesh N, Benoit LA, Berson EL, Shih VE, Gusella JF
Proc Natl Acad Sci U S A. 1988
PubMed ID: 3375240
An initiator codon mutation in ornithine-delta-aminotransferase causing gyrate atrophy of the choroid and retina.
Mitchell GA, Brody LC, Looney J, Steel G, Suchanek M, Dowling C, Der Kaloustian V, Kaiser-Kupfer M, Valle D
J Clin Invest. 1988
PubMed ID: 3339136
Chromosomal localization of human ornithine aminotransferase gene sequences to 10q26 and Xp11.2.
Barrett DJ, Bateman JB, Sparkes RS, Mohandas T, Klisak I, Inana G
Invest Ophthalmol Vis Sci. 1987
PubMed ID: 3596985
Investigation of gyrate atrophy using a cDNA clone for human ornithine aminotransferase.
Ramesh V, Shaffer MM, Allaire JM, Shih VE, Gusella JF
DNA. 1986
PubMed ID: 3816496
The primary structure of ornithine aminotransferase. Identification of active-site sequence and site of post-translational proteolysis.
Simmaco M, John RA, Barra D, Bossa F
FEBS Lett. 1986
PubMed ID: 3754226
Molecular cloning of human ornithine aminotransferase mRNA.
Inana G, Totsuka S, Redmond M, Dougherty T, Nagle J, Shiono T, Ohura T, Kominami E, Katunuma N
Proc Natl Acad Sci U S A. 1986
PubMed ID: 3456579
Sequence of the precursor to rat ornithine aminotransferase deduced from a cDNA clone.
Mueckler MM, Pitot HC
J Biol Chem. 1985
PubMed ID: 3840476
Ornithine delta-aminotransferase activity in retina and other tissues.
Rao GN, Cotlier E
Neurochem Res. 1984
PubMed ID: 6462326

Model Organism Phenotype Links from MGI Top Help

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	Human	Mouse	Rat
Entrez Gene	4942	18242	64313
EnsEMBL Gene(s)	ENSG00000065154	ENSMUSG00000030934	ENSRNOG00000016807
Unigene	Hs.523332	Mm.13694	Rn.1430
Homologene	OAT	Oat	Oat
OMIM	613349	N/A	N/A
GeneCards	OAT	N/A	N/A
Beta Cell Genomics	DT.100838550 DT.419122 DT.92064991 DT.92455333	DT.101151086 DT.537288	N/A
Reactome	P04181	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	4942	18242	64313

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