NPM1

Summary Top Help

Gene Description:

nucleophosmin 1; nucleophosmin (nucleolar phosphoprotein B23, numatrin)

Synonyms:

NPM, Npm1, B23, NO38, NPM1, Npm, B23NP

Orthologs:

Human NPM1 (protein-coding), Mouse Npm1 (protein-coding), Rat Npm1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr5:170814120..170838141 (242 kb) View in Genome Browser

(Mouse) NCBIM37 - chr11:33052287..33063206 (10.92 kb) View in Genome Browser

(Rat) RGSC3.4 - chr10:18051990..18062714 (10.72 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for NPM1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for NPM1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: 3

NCI-Nature Pathway Interaction Database: 4

Gene Ontology: 41

Publications from PubMed Top Help

Publications: 507

Age-dependent frequencies of NPM1 mutations and FLT3-ITD in patients with normal karyotype AML (NK-AML).
Schneider F, Hoster E, Schneider S, Dufour A, Benthaus T, Kakadia PM, Bohlander SK, Braess J, Heinecke A, Sauerland MC, Berdel WE, Buechner T, Woermann BJ, Feuring-Buske M, Buske C, Creutzig U, Thiede C, Zwaan MC, van den Heuvel-Eibrink MM, Reinhardt D, Hiddemann W, Spiekermann K
Ann Hematol. 2012
PubMed ID: 21744003
Amount of bone marrow blasts is strongly correlated to NPM1 and FLT3-ITD mutation rate in AML with normal karyotype.
Haferlach T, Bacher U, Alpermann T, Haferlach C, Kern W, Schnittger S
Leuk Res. 2012
PubMed ID: 21621842
Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs).
Lopitz-Otsoa F, Rodriguez-Suarez E, Aillet F, Casado-Vela J, Lang V, Matthiesen R, Elortza F, Rodriguez MS
J Proteomics. 2011
PubMed ID: 22178446
New centromeric component CENP-W is an RNA-associated nuclear matrix protein that interacts with nucleophosmin/B23 protein.
Chun Y, Park B, Koh W, Lee S, Cheon Y, Kim R, Che L, Lee S
J Biol Chem. 2011
PubMed ID: 22002061
Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
Nucleophosmin interacts with FOXM1 and modulates the level and localization of FOXM1 in human cancer cells.
Bhat UG, Jagadeeswaran R, Halasi M, Gartel AL
J Biol Chem. 2011
PubMed ID: 21979956
Fine-tuning nucleophosmin in macrophage differentiation and activation.
Guery L, Benikhlef N, Gautier T, Paul C, Jego G, Dufour E, Jacquel A, Cally R, Manoury B, Vanden Berghe T, Vandenabeele P, Droin N, Solary E
Blood. 2011
PubMed ID: 21876121
ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer.
Hu R, Peng G, Dai H, Breuer EK, Stemke-Hale K, Li K, Gonzalez-Angulo AM, Mills GB, Lin SY
Cancer Res. 2011
PubMed ID: 21852383
Nucleophosmin deposition during mRNA 3' end processing influences poly(A) tail length.
Sagawa F, Ibrahim H, Morrison AL, Wilusz CJ, Wilusz J
EMBO J. 2011
PubMed ID: 21822216
miR-10a overexpression is associated with NPM1 mutations and MDM4 downregulation in intermediate-risk acute myeloid leukemia.
Ovcharenko D, Stölzel F, Poitz D, Fierro F, Schaich M, Neubauer A, Kelnar K, Davison T, Müller-Tidow C, Thiede C, Bornhäuser M, Ehninger G, Brown D, Illmer T
Exp Hematol. 2011
PubMed ID: 21784052
Locked nucleic acid probes for enhanced detection of FLT3 D835/I836, JAK2 V617F and NPM1 mutations.
Warshawsky I, Mularo F
J Clin Pathol. 2011
PubMed ID: 21666141
Marked down-regulation of nucleophosmin-1 is associated with advanced del(5q) myelodysplastic syndrome.
Pellagatti A, Cazzola M, Giagounidis A, Perry J, Malcovati L, Della Porta MG, Jädersten M, Killick S, Vyas P, Hellström-Lindberg E, Wainscoat JS, Boultwood J
Br J Haematol. 2011
PubMed ID: 21492127
Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOS.
Zhang Q, Wang H, Kantekure K, Paterson JC, Liu X, Schaffer A, Paulos C, Milone MC, Odum N, Turner S, Marafioti T, Wasik MA
Blood. 2011
PubMed ID: 21765024
Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1.
Balusu R, Fiskus W, Rao R, Chong DG, Nalluri S, Mudunuru U, Ma H, Chen L, Venkannagari S, Ha K, Abhyankar S, Williams C, McGuirk J, Khoury HJ, Ustun C, Bhalla KN
Blood. 2011
PubMed ID: 21719597
Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.
Berndt JD, Aoyagi A, Yang P, Anastas JN, Tang L, Moon RT
J Cell Biol. 2011
PubMed ID: 21875946
Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis.
Mduff FK, Hook CE, Tooze RM, Huntly BJ, Pandolfi PP, Turner SD
Lab Invest. 2011
PubMed ID: 21709672
Autoregulatory circuit of human rpL3 expression requires hnRNP H1, NPM and KHSRP.
Russo A, Catillo M, Esposito D, Briata P, Pietropaolo C, Russo G
Nucleic Acids Res. 2011
PubMed ID: 21705779
Prognostic impact of white blood cell count in intermediate risk acute myeloid leukemia: relevance of mutated NPM1 and FLT3-ITD.
de Jonge HJ, Valk PJ, de Bont ES, Schuringa JJ, Ossenkoppele G, Vellenga E, Huls G
Haematologica. 2011
PubMed ID: 21606167
Detection of nucleophosmin 1 mutations by quantitative real-time polymerase chain reaction versus capillary electrophoresis: a comparative study.
Barakat FH, Luthra R, Yin CC, Barkoh BA, Hai S, Jamil W, Bhakta YI, Chen S, Medeiros LJ, Zuo Z
Arch Pathol Lab Med. 2011
PubMed ID: 21809990
Stella-Cre mice are highly efficient Cre deleters.
Liu H, Wang W, Chew SK, Lee SC, Li J, Vassiliou GS, Green T, Futreal PA, Bradley A, Zhang S, Liu P
Genesis. 2011
PubMed ID: 21786403
Prognostic impact of FLT3-ITD load in NPM1 mutated acute myeloid leukemia.
Schnittger S, Bacher U, Kern W, Alpermann T, Haferlach C, Haferlach T
Leukemia. 2011
PubMed ID: 21537333
DIGE-based proteomic analysis identifies nucleophosmin/B23 and nucleolin C23 as over-expressed proteins in relapsed/refractory acute leukemia.
Hu J, Lin M, Liu T, Li J, Chen B, Chen Y
Leuk Res. 2011
PubMed ID: 21310483
HIV-1 infection induces acetylation of NPM1 that facilitates Tat localization and enhances viral transactivation.
Gadad SS, Rajan RE, Senapati P, Chatterjee S, Shandilya J, Dash PK, Ranga U, Kundu TK
J Mol Biol. 2011
PubMed ID: 21763502
Fusion tyrosine kinase NPM-ALK Deregulates MSH2 and suppresses DNA mismatch repair function novel insights into a potent oncoprotein.
Young LC, Bone KM, Wang P, Wu F, Adam BA, Hegazy S, Gelebart P, Holovati J, Li L, Andrew SE, Lai R
Am J Pathol. 2011
PubMed ID: 21703420
Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: a study from the German-Austrian acute myeloid leukemia study group.
Krönke J, Schlenk RF, Jensen KO, Tschürtz F, Corbacioglu A, Gaidzik VI, Paschka P, Onken S, Eiwen K, Habdank M, Späth D, Lübbert M, Wattad M, Kindler T, Salih HR, Held G, Nachbaur D, von Lilienfeld-Toal M, Germing U, Haase D, Mergenthaler HG, Krauter J, Ganser A, Göhring G, Schlegelberger B, Döhner H, Döhner K
J Clin Oncol. 2011
PubMed ID: 21555683
The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway.
Martinelli P, Bonetti P, Sironi C, Pruneri G, Fumagalli C, Raviele PR, Volorio S, Pileri S, Chiarle R, McDuff FK, Tusi BK, Turner SD, Inghirami G, Pelicci PG, Colombo E
Blood. 2011
PubMed ID: 21518927
Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases.
Colombo E, Alcalay M, Pelicci PG
Oncogene. 2011
PubMed ID: 21278791
The importin-alpha/nucleophosmin switch controls taspase1 protease function.
Bier C, Knauer SK, Docter D, Schneider G, Krämer OH, Stauber RH
Traffic. 2011
PubMed ID: 21418451
CTNNBL1 Is a Novel Nuclear Localization Sequence-binding Protein That Recognizes RNA-splicing Factors CDC5L and Prp31.
Ganesh K, Adam S, Taylor B, Simpson P, Rada C, Neuberger M
J Biol Chem. 2011
PubMed ID: 21385873
Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice.
Vassiliou GS, Cooper JL, Rad R, Li J, Rice S, Uren A, Rad L, Ellis P, Andrews R, Banerjee R, Grove C, Wang W, Liu P, Wright P, Arends M, Bradley A
Nat Genet. 2011
PubMed ID: 21441929
NPM1 gene deletions in myelodysplastic syndromes with 5q- and complex karyotype.
Ammatuna E, Panetta P, Agirre X, Ottone T, Lavorgna S, Calasanz MJ, Lo-Coco F
Haematologica. 2011
PubMed ID: 21393327
Reply to: 'Flow cytometric identification of acute myeloid leukemia with limited differentiation and NPM1 type A mutation: a new biologically defined entity' by Kern et al.
Oelschlaegel U, Mohr B, Schaich M, Kroschinsky F, Parmentier S, Bornhäuser M, Ehninger G, Thiede C
Leukemia. 2011
PubMed ID: 21331074
A multiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1.
Narayan V, Halada P, Hernychová L, Chong YP, Žáková J, Hupp TR, Vojtesek B, Ball KL
J Biol Chem. 2011
PubMed ID: 21245151
Akt2 and nucleophosmin/B23 function as an oncogenic unit in human lung cancer cells.
Kim CK, Nguyen TL, Lee SB, Park SB, Lee KH, Cho SW, Ahn JY
Exp Cell Res. 2011
PubMed ID: 21182834
The multifunctional protein nucleophosmin (NPM1) is a human linker histone H1 chaperone.
Gadad SS, Senapati P, Syed SH, Rajan RE, Shandilya J, Swaminathan V, Chatterjee S, Colombo E, Dimitrov S, Pelicci PG, Ranga U, Kundu TK
Biochemistry. 2011
PubMed ID: 21425800
Involvement of the UL24 protein in herpes simplex virus 1-induced dispersal of B23 and in nuclear egress.
Lymberopoulos MH, Bourget A, Abdeljelil NB, Pearson A
Virology. 2011
PubMed ID: 21316727
Trisomy 11 as an isolated abnormality in acute myeloid leukemia is associated with unfavorable prognosis but not with an NPM1 or KIT mutation.
Alseraye FM, Zuo Z, Bueso-Ramos C, Wang S, Medeiros LJ, Lu G
Int J Clin Exp Pathol. 2011
PubMed ID: 21577323
Characterization of NPM1-mutated AML with a history of myelodysplastic syndromes or myeloproliferative neoplasms.
Schnittger S, Bacher U, Haferlach C, Alpermann T, Dicker F, Sundermann J, Kern W, Haferlach T
Leukemia. 2011
PubMed ID: 21233837
Prognostic factors in normal karyotype acute myeloid leukemia in the absence of the FLT3-ITD mutation.
Jiang A, Jiang H, Brandwein J, Kamel-Reid S, Chang H
Leuk Res. 2011
PubMed ID: 20684989
Oncogenic kinase NPM/ALK induces expression of HIF1α mRNA.
Marzec M, Liu X, Wong W, Yang Y, Pasha T, Kantekure K, Zhang P, Woetmann A, Cheng M, Odum N, Wasik MA
Oncogene. 2011
PubMed ID: 21102525
TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.
Yabuta Y, Ohta H, Abe T, Kurimoto K, Chuma S, Saitou M
J Cell Biol. 2011
PubMed ID: 21383078
Nucleophosmin delocalization in thyroid tumour cells.
Pianta A, Puppin C, Passon N, Franzoni A, Romanello M, Tell G, Di Loreto C, Bulotta S, Russo D, Damante G
Endocr Pathol. 2011
PubMed ID: 21258971
Nucleophosmin gene mutations promote NIH3T3 cell migration and invasion through CXCR4 and MMPs.
Shao HY, Miao ZY, Hui-Chen, Qin FX, Chen XC, Tan S, Zhang HJ, Wang L, Gao YJ, Yang ZL, Zhang L
Exp Mol Pathol. 2011
PubMed ID: 21122805
Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
Greco TM, Yu F, Guise AJ, Cristea IM
Mol Cell Proteomics. 2011
PubMed ID: 21081666
Serine phosphorylation of NPM-ALK, which is dependent on the auto-activation of the kinase activation loop, contributes to its oncogenic potential.
Wang P, Wu F, Zhang J, McMullen T, Young LC, Ingham RJ, Li L, Lai R
Carcinogenesis. 2011
PubMed ID: 21045017
Immunophenotype of acute myeloid leukemia with NPM mutations: prognostic impact of the leukemic compartment size.
Nomdedeu J, Bussaglia E, Villamor N, Martinez C, Esteve J, Tormo M, Estivill C, Queipo MP, Guardia R, Carricondo M, Hoyos M, Llorente A, Juncà J, Gallart M, Domingo A, Bargay J, Mascaró M, Moraleda JM, Florensa L, Ribera JM, Gallardo D, Brunet S, Aventin A, Sierra J, Spanish CETLAM
Leuk Res. 2011
PubMed ID: 20542566
Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?
Falini B, Martelli MP, Bolli N, Sportoletti P, Liso A, Tiacci E, Haferlach T
Blood. 2011
PubMed ID: 21030560
Identification of FUSE-binding protein 1 as a regulatory mRNA-binding protein that represses nucleophosmin translation.
Olanich ME, Moss BL, Piwnica-Worms D, Townsend RR, Weber JD
Oncogene. 2011
PubMed ID: 20802533
Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA
PLoS One. 2011
PubMed ID: 21731673
Knockdown of NPM1 by RNA interference inhibits cells proliferation and induces apoptosis in leukemic cell line.
Qin FX, Shao HY, Chen XC, Tan S, Zhang HJ, Miao ZY, Wang L, Hui-Chen, Zhang L
Int J Med Sci. 2011
PubMed ID: 21537492
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Detection of nucleophosmin and FMS-like tyrosine kinase-3 gene mutations in acute myeloid leukemia.
Pazhakh V, Zaker F, Alimoghaddam K, Atashrazm F
Ann Saudi Med. 2011
PubMed ID: 21245599
FLT3 and NPM1 mutations in myelodysplastic syndromes: Frequency and potential value for predicting progression to acute myeloid leukemia.
Bains A, Luthra R, Medeiros LJ, Zuo Z
Am J Clin Pathol. 2011
PubMed ID: 21173125
BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2.
Wang HF, Takenaka K, Nakanishi A, Miki Y
Cancer Res. 2011
PubMed ID: 21084279
The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.
Benedikt A, Baltruschat S, Scholz B, Bursen A, Arrey TN, Meyer B, Varagnolo L, Müller AM, Karas M, Dingermann T, Marschalek R
Leukemia. 2011
PubMed ID: 21030982
The prognostic value of multilineage dysplasia in de novo acute myeloid leukemia patients with intermediate-risk cytogenetics is dependent on NPM1 mutational status.
Díaz-Beyá M, Rozman M, Pratcorona M, Torrebadell M, Camós M, Aguilar JL, Esteve J
Blood. 2010
PubMed ID: 21183700
Monitoring of minimal residual disease in acute myeloid leukemia with frequent and rare patient-specific NPM1 mutations.
Dvorakova D, Racil Z, Jeziskova I, Palasek I, Protivankova M, Lengerova M, Razga F, Mayer J
Am J Hematol. 2010
PubMed ID: 20981679
Dephosphorylation of nucleophosmin by PP1β facilitates pRB binding and consequent E2F1-dependent DNA repair.
Lin CY, Tan BC, Liu H, Shih CJ, Chien KY, Lin CL, Yung BY
Mol Biol Cell. 2010
PubMed ID: 20962268
The role of nucleophosmin/B23 in radiation-induced chromosomal instability in human lymphoblastoid cells of different p53 genotypes.
Chen H, Jia R, Zhou M, Xu A, Hu Y, Cheng W, Shao C
Int J Radiat Biol. 2010
PubMed ID: 20807181
Incidence and significance of FLT3-ITD and NPM1 mutations in patients with normal karyotype acute myeloid leukaemia.
Haslam K, Chadwick N, Kelly J, Browne P, Vandenberghe E, Flynn C, Conneally E, Langabeer SE
Ir J Med Sci. 2010
PubMed ID: 20803351
Cytoplasmic FANCA-FANCC complex interacts and stabilizes the cytoplasm-dislocalized leukemic nucleophosmin protein (NPMc).
Du W, Li J, Sipple J, Chen J, Pang Q
J Biol Chem. 2010
PubMed ID: 20864535
Nucleophosmin C-terminal leukemia-associated domain interacts with G-rich quadruplex forming DNA.
Federici L, Arcovito A, Scaglione GL, Scaloni F, Lo Sterzo C, Di Matteo A, Falini B, Giardina B, Brunori M
J Biol Chem. 2010
PubMed ID: 20858903
CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice.
Martelli MP, Pettirossi V, Thiede C, Bonifacio E, Mezzasoma F, Cecchini D, Pacini R, Tabarrini A, Ciurnelli R, Gionfriddo I, Manes N, Rossi R, Giunchi L, Oelschlägel U, Brunetti L, Gemei M, Delia M, Specchia G, Liso A, Di Ianni M, Di Raimondo F, Falzetti F, Del Vecchio L, Martelli MF, Falini B
Blood. 2010
PubMed ID: 20634376
Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination.
Johansson H, Simonsson S
Aging (Albany NY). 2010
PubMed ID: 21076177
Absence of NPM1 promoter hypermethylation in human myelodysplastic syndrome.
Cheng YY, Chau D, Chan T, Gill H, Liang R, Kwong YL, Tse E
J Clin Pathol. 2010
PubMed ID: 20924036
ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia.
Gelsi-Boyer V, Trouplin V, Roquain J, Adélaïde J, Carbuccia N, Esterni B, Finetti P, Murati A, Arnoulet C, Zerazhi H, Fezoui H, Tadrist Z, Nezri M, Chaffanet M, Mozziconacci MJ, Vey N, Birnbaum D
Br J Haematol. 2010
PubMed ID: 20880116
Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition.
Leong SM, Tan BX, Bte Ahmad B, Yan T, Chee LY, Ang ST, Tay KG, Koh LP, Yeoh AE, Koay ES, Mok YK, Lim TM
Blood. 2010
PubMed ID: 20606168
Genomic, immunophenotypic, and NPM1/FLT3 mutational studies on 17 patients with normal karyotype acute myeloid leukemia (AML) followed by aberrant karyotype AML at relapse.
Wang ES, Sait SN, Gold D, Mashtare T, Starostik P, Ford LA, Wetzler M, Nowak NJ, Deeb G
Cancer Genet Cytogenet. 2010
PubMed ID: 20875872
The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status.
Green CL, Evans CM, Hills RK, Burnett AK, Linch DC, Gale RE
Blood. 2010
PubMed ID: 20651067
High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine.
Bachas C, Schuurhuis GJ, Hollink IH, Kwidama ZJ, Goemans BF, Zwaan CM, van den Heuvel-Eibrink MM, de Bont ES, Reinhardt D, Creutzig U, de Haas V, Assaraf YG, Kaspers GJ, Cloos J
Blood. 2010
PubMed ID: 20592250
FLT3 and NPM1 mutations in Chinese patients with acute myeloid leukemia and normal cytogenetics.
Wang L, Xu WL, Meng HT, Qian WB, Mai WY, Tong HY, Mao LP, Tong Y, Qian JJ, Lou YJ, Chen ZM, Wang YG, Jin J
J Zhejiang Univ Sci B. 2010
PubMed ID: 20872983
Is the association of "cup-like" nuclei with mutation of the NPM1 gene in acute myeloid leukemia clinically useful?
Bennett JM, Pryor J, Laughlin TS, Rothberg PG, Burack WR
Am J Clin Pathol. 2010
PubMed ID: 20855646
Minimal residual disease diagnostics in patients with acute myeloid leukemia in the post-transplant period: comparison of peripheral blood and bone marrow analysis.
Stahl T, Badbaran A, Kröger N, Klyuchnikov E, Zabelina T, Zeschke S, Schafhausen P, Schultz W, Asenova S, Smirnova A, Wolschke C, Ayuk F, Zander AR, Fehse B, Bacher U
Leuk Lymphoma. 2010
PubMed ID: 20849383
Rapid flow cytometric detection of aberrant cytoplasmic localization of nucleophosmin (NPMc) indicating mutant NPM1 gene in acute myeloid leukemia.
Oelschlaegel U, Koch S, Mohr B, Schaich M, Falini B, Ehninger G, Thiede C
Leukemia. 2010
PubMed ID: 20724983
Regulation of nucleolar chromatin by B23/nucleophosmin jointly depends upon its RNA binding activity and transcription factor UBF.
Hisaoka M, Ueshima S, Murano K, Nagata K, Okuwaki M
Mol Cell Biol. 2010
PubMed ID: 20713446
ETS-related gene ERG expression in AML patients is significantly associated with NPM1 mutation status.
Hämäläinen M, Juvonen V, Häikiö S, Lakkala T, Johansson J, Pelliniemi TT, Salmi TT, Remes K, Kairisto V
Eur J Haematol. 2010
PubMed ID: 20546020
Recruitment of phosphorylated NPM1 to sites of DNA damage through RNF8-dependent ubiquitin conjugates.
Koike A, Nishikawa H, Wu W, Okada Y, Venkitaraman AR, Ohta T
Cancer Res. 2010
PubMed ID: 20713529
Performance and clinical evaluation of a sensitive multiplex assay for the rapid detection of common NPM1 mutations.
Hafez M, Ye F, Jackson K, Yang Z, Karp JE, Labourier E, Gocke CD
J Mol Diagn. 2010
PubMed ID: 20616361
Localization of nucleophosmin in nuclear matrix and changes in its expression during the differentiation of human neuroblastoma induced by retinoic acid.
Shi SL, Liang Y, Li QF, Liu QR, Jing GJ, Wang SY, Zhang XY, Wu FY
J Cell Biochem. 2010
PubMed ID: 20506166
Nucleophosmin is recognized by a cytotoxic T cell line derived from a rectal carcinoma patient.
Swoboda RK, Somasundaram R, Caputo L, Berencsi K, von Franzke P, Taylor DD, Marincola FM, Meropol NJ, Sigurdson E, Miller E, Herlyn D
Int J Cancer. 2010
PubMed ID: 20027629
Involvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma growth.
Riera L, Lasorsa E, Ambrogio C, Surrenti N, Voena C, Chiarle R
J Biol Chem. 2010
PubMed ID: 20554525
Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
Pozuelo-Rubio M
FEBS J. 2010
PubMed ID: 20618440
Proteomic analysis of low- to high-grade astrocytomas reveals an alteration of the expression level of raf kinase inhibitor protein and nucleophosmin.
Gimenez M, Souza VC, Izumi C, Barbieri MR, Chammas R, Oba-Shinjo SM, Uno M, Marie SK, Rosa JC
Proteomics. 2010
PubMed ID: 20533335
Mutation analysis for RUNX1, MLL-PTD, FLT3-ITD, NPM1 and NRAS in 269 patients with MDS or secondary AML.
Dicker F, Haferlach C, Sundermann J, Wendland N, Weiss T, Kern W, Haferlach T, Schnittger S
Leukemia. 2010
PubMed ID: 20520634
Nucleophosmin, p53, and Ki-67 expression patterns on an oral squamous cell carcinoma tissue microarray.
Coutinho-Camillo CM, Lourenço SV, Nishimoto IN, Kowalski LP, Soares FA
Hum Pathol. 2010
PubMed ID: 20338617
Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.
Tando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, Mizutani T, Izumi T, Isobe T, Akiyama T, Inoue J, Iba H
J Biol Chem. 2010
PubMed ID: 20460684
Nucleophosmin is overexpressed in thyroid tumors.
Pianta A, Puppin C, Franzoni A, Fabbro D, Di Loreto C, Bulotta S, Deganuto M, Paron I, Tell G, Puxeddu E, Filetti S, Russo D, Damante G
Biochem Biophys Res Commun. 2010
PubMed ID: 20515654
State of oncomarker protein B23/nucleophosmin in HeLa cells.
Vladimirova NM, Lobanova NV, Potapenko NA
Biochemistry (Mosc). 2010
PubMed ID: 20673208
Studies of phosphoproteomic changes induced by nucleophosmin-anaplastic lymphoma kinase (ALK) highlight deregulation of tumor necrosis factor (TNF)/Fas/TNF-related apoptosis-induced ligand signaling pathway in ALK-positive anaplastic large cell lymphoma.
Wu F, Wang P, Zhang J, Young LC, Lai R, Li L
Mol Cell Proteomics. 2010
PubMed ID: 20393185
The tyrosine 343 residue of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions.
Hegazy SA, Wang P, Anand M, Ingham RJ, Gelebart P, Lai R
J Biol Chem. 2010
PubMed ID: 20424160
WT1 mutation in 470 adult patients with acute myeloid leukemia: stability during disease evolution and implication of its incorporation into a survival scoring system.
Hou HA, Huang TC, Lin LI, Liu CY, Chen CY, Chou WC, Tang JL, Tseng MH, Huang CF, Chiang YC, Lee FY, Liu MC, Yao M, Huang SY, Ko BS, Hsu SC, Wu SJ, Tsay W, Chen YC, Tien HF
Blood. 2010
PubMed ID: 20368469
Nucleophosmin/B23 inhibits Eg5-mediated microtubule depolymerization by inactivating its ATPase activity.
Wang G, Gao X, Huang Y, Yao Z, Shi Q, Wu M
J Biol Chem. 2010
PubMed ID: 20404347
Interleukin-9 (IL-9) and NPM-ALK each generate mast cell hyperplasia as single 'hit' and cooperate in producing a mastocytosis-like disease in mice.
Merz H, Kaehler C, Hoefig KP, Branke B, Uckert W, Nadrowitz R, Cerny-Reiterer S, Herrmann H, Feller AC, Valent P
Oncotarget. 2010
PubMed ID: 21297223
C/EBPA gene mutation and C/EBPA promoter hypermethylation in acute myeloid leukemia with normal cytogenetics.
Lu Y, Chen W, Chen W, Stein A, Weiss LM, Huang Q
Am J Hematol. 2010
PubMed ID: 20513120
Translationally controlled tumor protein interacts with nucleophosmin during mitosis in ES cells.
Johansson H, Vizlin-Hodzic D, Simonsson T, Simonsson S
Cell Cycle. 2010
PubMed ID: 20505363
Detection of t(3;5) and NPM1/MLF1 rearrangement in an elderly patient with acute myeloid leukemia: clinical and laboratory study with review of the literature.
Lim G, Choi JR, Kim MJ, Kim SY, Lee HJ, Suh JT, Yoon HJ, Lee J, Lee S, Lee WI, Park TS
Cancer Genet Cytogenet. 2010
PubMed ID: 20471513
Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations.
Green CL, Koo KK, Hills RK, Burnett AK, Linch DC, Gale RE
J Clin Oncol. 2010
PubMed ID: 20439648
Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways.
Kohlmann A, Bullinger L, Thiede C, Schaich M, Schnittger S, Döhner K, Dugas M, Klein HU, Döhner H, Ehninger G, Haferlach T
Leukemia. 2010
PubMed ID: 20428199
Identification of a hormone-regulated dynamic nuclear actin network associated with estrogen receptor alpha in human breast cancer cell nuclei.
Ambrosino C, Tarallo R, Bamundo A, Cuomo D, Franci G, Nassa G, Paris O, Ravo M, Giovane A, Zambrano N, Lepikhova T, Jänne OA, Baumann M, Nyman TA, Cicatiello L, Weisz A
Mol Cell Proteomics. 2010
PubMed ID: 20308691
Centrosome-related genes, genetic variation, and risk of breast cancer.
Olson JE, Wang X, Pankratz VS, Fredericksen ZS, Vachon CM, Vierkant RA, Cerhan JR, Couch FJ
Breast Cancer Res Treat. 2010
PubMed ID: 20508983
IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis.
Thol F, Weissinger EM, Krauter J, Wagner K, Damm F, Wichmann M, Goehring G, Schumann C, Bug G, Ottmann O, Hofmann WK, Schlegelberger B, Ganser A, Heuser M
Haematologica. 2010
PubMed ID: 20494930
Protein B23/nucleophosmin/numatrin nuclear dynamics in relation to protein kinase CK2 and apoptotic activity in prostate cells.
Wang G, Pan Y, Ahmad KA, Ahmed K
Biochemistry. 2010
PubMed ID: 20387789
Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor.
Wagner K, Damm F, Göhring G, Görlich K, Heuser M, Schäfer I, Ottmann O, Lübbert M, Heit W, Kanz L, Schlimok G, Raghavachar AA, Fiedler W, Kirchner HH, Brugger W, Zucknick M, Schlegelberger B, Heil G, Ganser A, Krauter J
J Clin Oncol. 2010
PubMed ID: 20368538
Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1).
Falini B, Macijewski K, Weiss T, Bacher U, Schnittger S, Kern W, Kohlmann A, Klein HU, Vignetti M, Piciocchi A, Fazi P, Martelli MP, Vitale A, Pileri S, Miesner M, Santucci A, Haferlach C, Mandelli F, Haferlach T
Blood. 2010
PubMed ID: 20203266
Nucleophosmin gene mutation in acute myeloid leukemia patients.
Khorshied MM, Said WA, Shaaban HA
Saudi Med J. 2010
PubMed ID: 20464055
Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis.
Ren J, Wang Y, Liang Y, Zhang Y, Bao S, Xu Z
J Biol Chem. 2010
PubMed ID: 20159986
A novel LZAP-binding protein, NLBP, inhibits cell invasion.
Kwon J, Cho HJ, Han SH, No JG, Kwon JY, Kim H
J Biol Chem. 2010
PubMed ID: 20164180
Characterization of the DOT1L network: implications of diverse roles for DOT1L.
Park G, Gong Z, Chen J, Kim JE
Protein J. 2010
PubMed ID: 20431927
NPM1 is overexpressed in hyperdiploid multiple myeloma due to a gain of chromosome 5 but is not delocalized to the cytoplasm.
Weinhold N, Moreaux J, Raab MS, Hose D, Hielscher T, Benner A, Meissner T, Ehrbrecht E, Brough M, Jauch A, Goldschmidt H, Klein B, Moos M
Genes Chromosomes Cancer. 2010
PubMed ID: 20073075
Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain.
Scaloni F, Federici L, Brunori M, Gianni S
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20212148
NSP 5a3a's link to nuclear-cyto proteins B23 and hnRNP-L between normal and aberrant breast cell lines.
D'Agostino L, Caracciolo V, Giordano A
Cell Cycle. 2010
PubMed ID: 20237420
Favorable outcome in patients with acute myeloid leukemia with NPM1 mutation autografted after conditioning with high dose continuous infusion idarubicin and busulphan.
Ferrara F, Izzo T, Criscuolo C, Riccardi C, Muccioli G, Viola A, Pane F, Palmieri S
Biol Blood Marrow Transplant. 2010
PubMed ID: 20172040
Tumor suppressor HLJ1 binds and functionally alters nucleophosmin via activating enhancer binding protein 2alpha complex formation.
Chang TP, Yu SL, Lin SY, Hsiao YJ, Chang GC, Yang PC, Chen JJ
Cancer Res. 2010
PubMed ID: 20145123
The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: overall results and results in genotypic subgroups defined by mutations in NPM1, FLT3, and C
Burnett AK, Hills RK, Green C, Jenkinson S, Koo K, Patel Y, Guy C, Gilkes A, Milligan DW, Goldstone AH, Prentice AG, Wheatley K, Linch DC, Gale RE
Blood. 2010
PubMed ID: 19965647
[Correlation of adult AML Npm1 mutations with prognosis and its relationship with gene mutation of FLT3 and CEBPA].
Bao LY, Wang JS
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010
PubMed ID: 20137111
Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study.
Becker H, Marcucci G, Maharry K, Radmacher MD, Mrózek K, Margeson D, Whitman SP, Wu YZ, Schwind S, Paschka P, Powell BL, Carter TH, Kolitz JE, Wetzler M, Carroll AJ, Baer MR, Caligiuri MA, Larson RA, Bloomfield CD
J Clin Oncol. 2010
PubMed ID: 20026798
Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells.
Adon AM, Zeng X, Harrison MK, Sannem S, Kiyokawa H, Kaldis P, Saavedra HI
Mol Cell Biol. 2010
PubMed ID: 19933848
Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias.
Carbuccia N, Trouplin V, Gelsi-Boyer V, Murati A, Rocquain J, Adélaïde J, Olschwang S, Xerri L, Vey N, Chaffanet M, Birnbaum D, Mozziconacci MJ
Leukemia. 2010
PubMed ID: 19865112
Novel immunophenotypic and morphologic presentation in acute myeloid leukemia (AML) with JAK2 V617F mutation.
Swaminathan S, Madkaikar M, Ghosh K, Vundinti BR, Kerketta L, Gupta M
Eur J Haematol. 2010
PubMed ID: 19824900
Strikingly different molecular relapse kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 acute myeloid leukemias.
Ommen HB, Schnittger S, Jovanovic JV, Ommen IB, Hasle H, Østergaard M, Grimwade D, Hokland P
Blood. 2010
PubMed ID: 19901261
[FLT3 and NPM1 gene mutations in patients with acute myeloid leukemias and the impact of FLT3-ITD mutations on the survival of patients with a normal karyotype].
Martynkevich IS, Gritsaev SV, Moskalenko MV, Ivanova MP, Aksenova VIu, Tiranova SA, Abdulkadyrov KM
Ter Arkh. 2010
PubMed ID: 21516736
Fms like tyrosine kinase (FLT3) and nucleophosmin 1 (NPM1) mutations in de novo normal karyotype acute myeloid leukemia (AML).
Dunna NR, Rajappa S, Digumarti R, Vure S, Kagita S, Damineni S, Rao VR, Yadav SK, Ravuri RR, Satti V
Asian Pac J Cancer Prev. 2010
PubMed ID: 21338238
The frequency of NPM1 mutations in childhood acute myeloid leukemia.
Braoudaki M, Papathanassiou C, Katsibardi K, Tourkadoni N, Karamolegou K, Tzortzatou-Stathopoulou F
J Hematol Oncol. 2010
PubMed ID: 20979630
NPM1 deletion is associated with gross chromosomal rearrangements in leukemia.
La Starza R, Matteucci C, Gorello P, Brandimarte L, Pierini V, Crescenzi B, Nofrini V, Rosati R, Gottardi E, Saglio G, Santucci A, Berchicci L, Arcioni F, Falini B, Martelli MF, Sambani C, Aventin A, Mecucci C
PLoS One. 2010
PubMed ID: 20877721
EMG1 is essential for mouse pre-implantation embryo development.
Wu X, Sandhu S, Patel N, Triggs-Raine B, Ding H
BMC Dev Biol. 2010
PubMed ID: 20858271
Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias.
Rocquain J, Carbuccia N, Trouplin V, Raynaud S, Murati A, Nezri M, Tadrist Z, Olschwang S, Vey N, Birnbaum D, Gelsi-Boyer V, Mozziconacci MJ
BMC Cancer. 2010
PubMed ID: 20678218
Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication.
Krause A, Hoffmann I
PLoS One. 2010
PubMed ID: 20352051
Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency.
Sarek G, Järviluoma A, Moore HM, Tojkander S, Vartia S, Biberfeld P, Laiho M, Ojala PM
PLoS Pathog. 2010
PubMed ID: 20333249
Acute myeloid leukemia with mutated nucleophosmin (NPM1): molecular, pathological, and clinical features.
Falini B
Cancer Treat Res. 2010
PubMed ID: 20306250
Cytoplasmic expression of nucleophosmin accurately predicts mutation in the nucleophosmin gene in patients with acute myeloid leukemia and normal karyotype.
Luo J, Qi C, Xu W, Kamel-Reid S, Brandwein J, Chang H
Am J Clin Pathol. 2010
PubMed ID: 20023256
Genetic changes including gene copy number alterations and their relation to prognosis in childhood acute myeloid leukemia.
Armengol G, Canellas A, Alvarez Y, Bastida P, Toledo JS, Pérez-Iribarne Mdel M, Camós M, Tuset E, Estella J, Coll MD, Caballín MR, Knuutila S
Leuk Lymphoma. 2010
PubMed ID: 20001230
The SMN interactome includes Myb-binding protein 1a.
Fuller HR, Man NT, Lam le T, Thanh le T, Keough RA, Asperger A, Gonda TJ, Morris GE
J Proteome Res. 2010
PubMed ID: 19928837
Functional characterization of the kinase activation loop in nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) using tandem affinity purification and liquid chromatography-mass spectrometry.
Wang P, Wu F, Ma Y, Li L, Lai R, Young LC
J Biol Chem. 2010
PubMed ID: 19887368
Hepatitis B virus core interacts with the host cell nucleolar protein, nucleophosmin 1.
Lee SJ, Shim HY, Hsieh A, Min JY, Jung G
J Microbiol. 2009
PubMed ID: 20127469
B23 interacts with PES1 and is involved in nucleolar localization of PES1.
Zhang J, Yang Y, Wu J
Acta Biochim Biophys Sin (Shanghai). 2009
PubMed ID: 20011973
FLT3-ITD expression levels and their effect on STAT5 in AML with and without NPM mutations.
Seedhouse CH, Pallis M, Grundy M, Shang S, Russell NH
Br J Haematol. 2009
PubMed ID: 19775300
Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity.
Rau R, Brown P
Hematol Oncol. 2009
PubMed ID: 19569254
Inhibiting Crm1 causes the formation of excess acentriolar spindle poles containing NuMA and B23, but does not affect centrosome numbers.
Rousselet A
Biol Cell. 2009
PubMed ID: 19522705
RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells.
Jian Y, Gao Z, Sun J, Shen Q, Feng F, Jing Y, Yang C
Oncogene. 2009
PubMed ID: 19734942
Regulation of protein Citrullination through p53/PADI4 network in DNA damage response.
Tanikawa C, Ueda K, Nakagawa H, Yoshida N, Nakamura Y, Matsuda K
Cancer Res. 2009
PubMed ID: 19843866
Acute myeloid leukemia with mutated NPM1: diagnosis, prognosis and therapeutic perspectives.
Falini B, Sportoletti P, Martelli MP
Curr Opin Oncol. 2009
PubMed ID: 19770764
The DNA methylome of pediatric acute lymphoblastic leukemia.
Davidsson J, Lilljebjörn H, Andersson A, Veerla S, Heldrup J, Behrendtz M, Fioretos T, Johansson B
Hum Mol Genet. 2009
PubMed ID: 19679565
Detection of FLT3/ITD, JAK2(V617F) and NPM1 gene mutations in chronic myelomonocytic leukemia.
Chen W, Huang Q
Leuk Res. 2009
PubMed ID: 19540590
The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.
Crawford NP, Yang H, Mattaini KR, Hunter KW
J Biol Chem. 2009
PubMed ID: 19710015
Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis.
Konoplev S, Huang X, Drabkin HA, Koeppen H, Jones D, Kantarjian HM, Garcia-Manero G, Chen W, Medeiros LJ, Bueso-Ramos CE
Cancer. 2009
PubMed ID: 19637342
Nucleophosmin/B23 regulates ubiquitin dynamics in nucleoli by recruiting deubiquitylating enzyme USP36.
Endo A, Kitamura N, Komada M
J Biol Chem. 2009
PubMed ID: 19679658
Interaction with checkpoint kinase 1 modulates the recruitment of nucleophosmin to chromatin.
Chen S, Maya-Mendoza A, Zeng K, Tang CW, Sims PF, Loric J, Jackson DA
J Proteome Res. 2009
PubMed ID: 19694479
GAGE, an antiapoptotic protein binds and modulates the expression of nucleophosmin/B23 and interferon regulatory factor 1.
Kular RK, Yehiely F, Kotlo KU, Cilensek ZM, Bedi R, Deiss LP
J Interferon Cytokine Res. 2009
PubMed ID: 19642896
Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.
Matafora V, D'Amato A, Mori S, Blasi F, Bachi A
Mol Cell Proteomics. 2009
PubMed ID: 19596686
AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features.
Haferlach C, Mecucci C, Schnittger S, Kohlmann A, Mancini M, Cuneo A, Testoni N, Rege-Cambrin G, Santucci A, Vignetti M, Fazi P, Martelli MP, Haferlach T, Falini B
Blood. 2009
PubMed ID: 19429869
Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML.
Schnittger S, Kern W, Tschulik C, Weiss T, Dicker F, Falini B, Haferlach C, Haferlach T
Blood. 2009
PubMed ID: 19587375
Nucleophosmin protein expression level, but not threonine 198 phosphorylation, is essential in growth and proliferation.
Brady SN, Maggi LB, Winkeler CL, Toso EA, Gwinn AS, Pelletier CL, Weber JD
Oncogene. 2009
PubMed ID: 19561638
Nucleophosmin may act as an alarmin: implications for severe sepsis.
Nawa Y, Kawahara K, Tancharoen S, Meng X, Sameshima H, Ito T, Masuda Y, Imaizumi H, Hashiguchi T, Maruyama I
J Leukoc Biol. 2009
PubMed ID: 19581374
Acetylated NPM1 localizes in the nucleoplasm and regulates transcriptional activation of genes implicated in oral cancer manifestation.
Shandilya J, Swaminathan V, Gadad SS, Choudhari R, Kodaganur GS, Kundu TK
Mol Cell Biol. 2009
PubMed ID: 19581289
The proteomic signature of NPM/ALK reveals deregulation of multiple cellular pathways.
Lim MS, Carlson ML, Crockett DK, Fillmore GC, Abbott DR, Elenitoba-Johnson OF, Tripp SR, Rassidakis GZ, Medeiros LJ, Szankasi P, Elenitoba-Johnson KS
Blood. 2009
PubMed ID: 19531656
Nucleophosmin redistribution following heat shock: a role in heat-induced radiosensitization.
Vanderwaal RP, Maggi LB, Weber JD, Hunt CR, Roti Roti JL
Cancer Res. 2009
PubMed ID: 19638589
Wilms tumor 1 gene mutations are associated with a higher risk of recurrence in young adults with acute myeloid leukemia: a study from the Acute Leukemia French Association.
Renneville A, Boissel N, Zurawski V, Llopis L, Biggio V, Nibourel O, Philippe N, Thomas X, Dombret H, Preudhomme C
Cancer. 2009
PubMed ID: 19536888
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Cuplike nuclei (prominent nuclear invaginations) in acute myeloid leukemia are highly associated with FLT3 internal tandem duplication and NPM1 mutation.
Chen W, Konoplev S, Medeiros LJ, Koeppen H, Leventaki V, Vadhan-Raj S, Jones D, Kantarjian HM, Falini B, Bueso-Ramos CE
Cancer. 2009
PubMed ID: 19672946
Comprehensive analysis of cooperative gene mutations between class I and class II in de novo acute myeloid leukemia.
Ishikawa Y, Kiyoi H, Tsujimura A, Miyawaki S, Miyazaki Y, Kuriyama K, Tomonaga M, Naoe T
Eur J Haematol. 2009
PubMed ID: 19309322
Folding mechanism of the C-terminal domain of nucleophosmin: residual structure in the denatured state and its pathophysiological significance.
Scaloni F, Gianni S, Federici L, Falini B, Brunori M
FASEB J. 2009
PubMed ID: 19289604
IGF-IR tyrosine kinase interacts with NPM-ALK oncogene to induce survival of T-cell ALK+ anaplastic large-cell lymphoma cells.
Shi P, Lai R, Lin Q, Iqbal AS, Young LC, Kwak LW, Ford RJ, Amin HM
Blood. 2009
PubMed ID: 19423729
The effect of the cyclin-dependent kinase inhibitor flavopiridol on anaplastic large cell lymphoma cells and relationship with NPM-ALK kinase expression and activity.
Bonvini P, Zorzi E, Mussolin L, Monaco G, Pigazzi M, Basso G, Rosolen A
Haematologica. 2009
PubMed ID: 19535344
Non-A type nucleophosmin 1 gene mutation predicts poor clinical outcome in de novo adult acute myeloid leukemia: differential clinical importance of NPM1 mutation according to subtype.
Koh Y, Park J, Bae EK, Ahn KS, Kim I, Bang SM, Lee JH, Yoon SS, Lee DS, Lee YY, Park S, Kim BK
Int J Hematol. 2009
PubMed ID: 19484332
Flow cytometric identification of acute myeloid leukemia with limited differentiation and NPM1 type A mutation: a new biologically defined entity.
Kern W, Haferlach C, Bacher U, Haferlach T, Schnittger S
Leukemia. 2009
PubMed ID: 19369962
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
Incidence of FLT3 and nucleophosmin gene mutations in childhood acute myeloid leukemia: Serbian experience and the review of the literature.
Krstovski N, Tosic N, Janic D, Dokmanovic L, Kuzmanovic M, Spasovski V, Pavlovic S
Med Oncol. 2009
PubMed ID: 19557552
Nucleophosmin blocks mitochondrial localization of p53 and apoptosis.
Dhar SK, St Clair DK
J Biol Chem. 2009
PubMed ID: 19366707
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Mutations of NPM1 gene in de novo acute myeloid leukaemia: determination of incidence, distribution pattern and identification of two novel mutations in Indian population.
Ahmad F, Mandava S, Das BR
Hematol Oncol. 2009
PubMed ID: 19365794
NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner.
Cui YX, Kerby A, McDuff FK, Ye H, Turner SD
Blood. 2009
PubMed ID: 19286999
NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high-risk myelodysplastic syndrome (MDS).
Schneider F, Hoster E, Unterhalt M, Schneider S, Dufour A, Benthaus T, Mellert G, Zellmeier E, Bohlander SK, Feuring-Buske M, Buske C, Braess J, Fritsch S, Heinecke A, Sauerland MC, Berdel WE, Buechner T, Woermann BJ, Hiddemann W, Spiekermann K
Blood. 2009
PubMed ID: 19279329
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres.
Dunleavy EM, Roche D, Tagami H, Lacoste N, Ray-Gallet D, Nakamura Y, Daigo Y, Nakatani Y, Almouzni-Pettinotti G
Cell. 2009
PubMed ID: 19410545
Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.
Foltz DR, Jansen LE, Bailey AO, Yates JR, Bassett EA, Wood S, Black BE, Cleveland DW
Cell. 2009
PubMed ID: 19410544
The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival.
Barkić M, Crnomarković S, Grabusić K, Bogetić I, Panić L, Tamarut S, Cokarić M, Jerić I, Vidak S, Volarević S
Mol Cell Biol. 2009
PubMed ID: 19273598
Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ
Mol Cell Proteomics. 2009
PubMed ID: 19131326
Nucleophosmin as a candidate prognostic biomarker of Ewing's sarcoma revealed by proteomics.
Kikuta K, Tochigi N, Shimoda T, Yabe H, Morioka H, Toyama Y, Hosono A, Beppu Y, Kawai A, Hirohashi S, Kondo T
Clin Cancer Res. 2009
PubMed ID: 19351769
[Analysis of NPM1 gene mutations in acute myeloid leukemia]
Dai D, Zhang SJ, Qiao C, Sun XM, Qian SX, Xu W, Xu YL, Li JY
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009
PubMed ID: 19379554
Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.
Maddika S, Chen J
Nat Cell Biol. 2009
PubMed ID: 19287380
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.
Vascotto C, Fantini D, Romanello M, Cesaratto L, Deganuto M, Leonardi A, Radicella JP, Kelley MR, D'Ambrosio C, Scaloni A, Quadrifoglio F, Tell G
Mol Cell Biol. 2009
PubMed ID: 19188445
The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL.
Boccalatte FE, Voena C, Riganti C, Bosia A, D'Amico L, Riera L, Cheng M, Ruggeri B, Jensen ON, Goss VL, Lee K, Nardone J, Rush J, Polakiewicz RD, Comb MJ, Chiarle R, Inghirami G
Blood. 2009
PubMed ID: 18845790
Nucleophosmin/B23 interacts with p21WAF1/CIP1 and contributes to its stability.
Xiao J, Zhang Z, Chen GG, Zhang M, Ding Y, Fu J, Li M, Yun JP
Cell Cycle. 2009
PubMed ID: 19221506
A dose-dependent tug of war involving the NPM1 leukaemic mutant, nucleophosmin, and ARF.
Bolli N, De Marco MF, Martelli MP, Bigerna B, Pucciarini A, Rossi R, Mannucci R, Manes N, Pettirossi V, Pileri SA, Nicoletti I, Falini B
Leukemia. 2009
PubMed ID: 19005479
Structural basis and specificity of human otubain 1-mediated deubiquitination.
Edelmann MJ, Iphöfer A, Akutsu M, Altun M, di Gleria K, Kramer HB, Fiebiger E, Dhe-Paganon S, Kessler BM
Biochem J. 2009
PubMed ID: 18954305
Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing.
Cullen SP, Afonina IS, Donadini R, Lüthi AU, Medema JP, Bird PI, Martin SJ
J Biol Chem. 2009
PubMed ID: 19103589
Proteome-wide identification of novel binding partners to the oncogenic fusion gene protein, NPM-ALK, using tandem affinity purification and mass spectrometry.
Wu F, Wang P, Young LC, Lai R, Li L
Am J Pathol. 2009
PubMed ID: 19131589
Cytoplasmic nucleophosmin is not detected in blastic plasmacytoid dendritic cell neoplasm.
Facchetti F, Pileri SA, Agostinelli C, Martelli MP, Paulli M, Venditti A, Martelli MF, Falini B
Haematologica. 2009
PubMed ID: 19066330
Monitoring minimal residual disease in acute myeloid leukaemia with NPM1 mutations by quantitative PCR: clonal evolution is a limiting factor.
Papadaki C, Dufour A, Seibl M, Schneider S, Bohlander SK, Zellmeier E, Mellert G, Hiddemann W, Spiekermann K
Br J Haematol. 2009
PubMed ID: 19055671
Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on cytogenetically normal AML.
Hollink IH, Zwaan CM, Zimmermann M, Arentsen-Peters TC, Pieters R, Cloos J, Kaspers GJ, de Graaf SS, Harbott J, Creutzig U, Reinhardt D, van den Heuvel-Eibrink MM, Thiede C
Leukemia. 2009
PubMed ID: 19020547
The prognostic impact of 17p (p53) deletion in 2272 adults with acute myeloid leukemia.
Seifert H, Mohr B, Thiede C, Oelschlägel U, Schäkel U, Illmer T, Soucek S, Ehninger G, Schaich M
Leukemia. 2009
PubMed ID: 19151774
Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles.
Guo Y, Zhang X, Huang J, Zeng Y, Liu W, Geng C, Li KW, Yang D, Wu S, Wei H, Han Z, Qian X, Jiang Y, He F
PLoS One. 2009
PubMed ID: 19865483
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
In vitro nuclear interactome of the HIV-1 Tat protein.
Gautier VW, Gu L, O'Donoghue N, Pennington S, Sheehy N, Hall WW
Retrovirology. 2009
PubMed ID: 19454010
Detection of nucleophosmin gene mutations in plasma from patients with acute myeloid leukemia: clinical significance and implications.
Ma W, Kantarjian H, Zhang X, Jilani I, Sheikholeslami MR, Donahue AC, Ravandi F, Estey E, O'Brien S, Keating M, Giles FJ, Albitar M
Cancer Biomark. 2009
PubMed ID: 19242062
The phagosomal proteome in interferon-gamma-activated macrophages.
Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P
Immunity. 2009
PubMed ID: 19144319
Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B.
Schlenk RF, Döhner K, Kneba M, Götze K, Hartmann F, Del Valle F, Kirchen H, Koller E, Fischer JT, Bullinger L, Habdank M, Späth D, Groner S, Krebs B, Kayser S, Corbacioglu A, Anhalt A, Benner A, Fröhling S, Döhner H, German-Austrian AML Study Group (AMLSG)
Haematologica. 2009
PubMed ID: 19059939
Simultaneous occurrence of acute myeloid leukaemia with mutated nucleophosmin (NPM1) in the same family.
Cazzaniga G, Lo Nigro L, Cifola I, Milone G, Schnittger S, Haferlach T, Mirabile E, Costantino F, Martelli MP, Mastrodicasa E, Di Raimondo F, Aversa F, Biondi A, Falini B
Leukemia. 2009
PubMed ID: 18596743
Disruption of ATP binding destabilizes NPM/B23 and inhibits anti-apoptotic function.
Choi JW, Lee SB, Ahn JY, Lee KH
BMB Rep. 2008
PubMed ID: 19123973
Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.
Wang B, Malik R, Nigg EA, Körner R
Anal Chem. 2008
PubMed ID: 19007248
Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation.
Li Z, Boone D, Hann SR
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19033198
Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
Carrascal M, Ovelleiro D, Casas V, Gay M, Abian J
J Proteome Res. 2008
PubMed ID: 19367720
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
Human protein factory for converting the transcriptome into an in vitro-expressed proteome,.
Goshima N, Kawamura Y, Fukumoto A, Miura A, Honma R, Satoh R, Wakamatsu A, Yamamoto J, Kimura K, Nishikawa T, Andoh T, Iida Y, Ishikawa K, Ito E, Kagawa N, Kaminaga C, Kanehori K, Kawakami B, Kenmochi K, Kimura R, Kobayashi M, Kuroita T, Kuwayama H, Maruyama Y, Matsuo K, Minami K, Mitsubori M, Mori M, Morishita R, Murase A, Nishikawa A, Nishikawa S, Okamoto T, Sakagami N, Sakamoto Y, Sasaki Y, Seki T, Sono S, Sugiyama A, Sumiya T, Takayama T, Takayama Y, Takeda H, Togashi T, Yahata K, Yamada H, Yanagisawa Y, Endo Y, Imamoto F, Kisu Y, Tanaka S, Isogai T, Imai J, Watanabe S, Nomura N
Nat Methods. 2008
PubMed ID: 19054851
Abnormal cytoplasmic dyslocalisation and/or reduction of nucleophosmin protein level rarely occurs in myelodysplastic syndromes.
Ishikawa Y, Xu J, Sakashita G, Urano T, Suzuki T, Tomita A, Kiyoi H, Nakamura S, Naoe T
Leuk Lymphoma. 2008
PubMed ID: 19052985
Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.
Maggi LB, Kuchenruether M, Dadey DY, Schwope RM, Grisendi S, Townsend RR, Pandolfi PP, Weber JD
Mol Cell Biol. 2008
PubMed ID: 18809582
Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice.
Parlato R, Kreiner G, Erdmann G, Rieker C, Stotz S, Savenkova E, Berger S, Grummt I, Schütz G
J Neurosci. 2008
PubMed ID: 19036968
Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases.
Yun C, Wang Y, Mukhopadhyay D, Backlund P, Kolli N, Yergey A, Wilkinson KD, Dasso M
J Cell Biol. 2008
PubMed ID: 19015314
Nucleophosmin is required for chromosome congression, proper mitotic spindle formation, and kinetochore-microtubule attachment in HeLa cells.
Amin MA, Matsunaga S, Uchiyama S, Fukui K
FEBS Lett. 2008
PubMed ID: 18951898
Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3.
Kuo ML, den Besten W, Thomas MC, Sherr CJ
Cell Cycle. 2008
PubMed ID: 18948745
Depletion of nucleophosmin leads to distortion of nucleolar and nuclear structures in HeLa cells.
Amin MA, Matsunaga S, Uchiyama S, Fukui K
Biochem J. 2008
PubMed ID: 18729828
Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival.
Lee SB, Xuan Nguyen TL, Choi JW, Lee KH, Cho SW, Liu Z, Ye K, Bae SS, Ahn JY
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18931307
Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation.
Gandin V, Miluzio A, Barbieri AM, Beugnet A, Kiyokawa H, Marchisio PC, Biffo S
Nature. 2008
PubMed ID: 18784653
Nucleophosmin mutation in Southeast Asian acute myeloid leukemia: eight novel variants, FLT3 coexistence and prognostic impact of NPM1/FLT3 mutations.
Boonthimat C, Thongnoppakhun W, Auewarakul CU
Haematologica. 2008
PubMed ID: 18641025
SMT3IP1, a nucleolar SUMO-specific protease, deconjugates SUMO-2 from nucleolar and cytoplasmic nucleophosmin.
Nishida T, Yamada Y
Biochem Biophys Res Commun. 2008
PubMed ID: 18639523
A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth.
Wanzel M, Russ AC, Kleine-Kohlbrecher D, Colombo E, Pelicci PG, Eilers M
Nat Cell Biol. 2008
PubMed ID: 19160485
Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.
Zhou H, Ye M, Dong J, Han G, Jiang X, Wu R, Zou H
J Proteome Res. 2008
PubMed ID: 18630941
Minimal residual disease detection in acute myeloid leukemia by mutant nucleophosmin (NPM1): comparison with WT1 gene expression.
Barragan E, Pajuelo JC, Ballester S, Fuster O, Cervera J, Moscardo F, Senent L, Such E, Sanz MA, Bolufer P
Clin Chim Acta. 2008
PubMed ID: 18590714
Nucleophosmin mutations in Chinese adults with acute myelogenous leukemia.
Ruan GR, Li JL, Qin YZ, Li LD, Xie M, Chang Y, Zhang Y, Liu YR, Jiang B, Chen SS, Huang XJ
Ann Hematol. 2008
PubMed ID: 18726096
Structural consequences of nucleophosmin mutations in acute myeloid leukemia.
Grummitt CG, Townsley FM, Johnson CM, Warren AJ, Bycroft M
J Biol Chem. 2008
PubMed ID: 18511415
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1).
Liso A, Castiglione F, Cappuccio A, Stracci F, Schlenk RF, Amadori S, Thiede C, Schnittger S, Valk PJ, Döhner K, Martelli MF, Schaich M, Krauter J, Ganser A, Martelli MP, Bolli N, Löwenberg B, Haferlach T, Ehninger G, Mandelli F, Döhner H, Michor F, Falini B
Haematologica. 2008
PubMed ID: 18603563
Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma.
Bonetti P, Davoli T, Sironi C, Amati B, Pelicci PG, Colombo E
J Cell Biol. 2008
PubMed ID: 18625840
Nucleophosmin is a binding partner of nucleostemin in human osteosarcoma cells.
Ma H, Pederson T
Mol Biol Cell. 2008
PubMed ID: 18448670
NPM1-mutated acute myeloid leukaemia occurring in JAK2-V617F+ primary myelofibrosis: de-novo origin?
Pasqualucci L, Li S, Meloni G, Schnittger S, Gattenlohner S, Liso A, Di Ianni M, Martelli MP, Pescarmona E, Foa R, Haferlach T, Skoda RC, Falini B
Leukemia. 2008
PubMed ID: 18200037
DR negativity is a distinctive feature of M1/M2 AML cases with NPM1 mutation.
Syampurnawati M, Tatsumi E, Ardianto B, Takenokuchi M, Nakamachi Y, Kawano S, Kumagai S, Saigo K, Matsui T, Takahashi T, Nagai K, Gunadi, Nishio H, Yabe H, Kondo S, Hayashi Y
Leuk Res. 2008
PubMed ID: 18180033
Wilms Tumor 1 Gene Mutations Independently Predict Poor Outcome in Adults With Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study.
Paschka P, Marcucci G, Ruppert AS, Whitman SP, Mrózek K, Maharry K, Langer C, Baldus CD, Zhao W, Powell BL, Baer MR, Carroll AJ, Caligiuri MA, Kolitz JE, Larson RA, Bloomfield CD
J Clin Oncol. 2008
PubMed ID: 18559874
Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation.
Lindström MS, Zhang Y
J Biol Chem. 2008
PubMed ID: 18420587
p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation.
Cuomo ME, Knebel A, Morrice N, Paterson H, Cohen P, Mittnacht S
Nat Cell Biol. 2008
PubMed ID: 18454140
In human genome, generation of a nuclear export signal through duplication appears unique to nucleophosmin (NPM1) mutations and is restricted to AML.
Liso A, Bogliolo A, Freschi V, Martelli MP, Pileri SA, Santodirocco M, Bolli N, Martelli MF, Falini B
Leukemia. 2008
PubMed ID: 18059485
Therapy-related acute myeloid leukaemia with mutated NPM1: treatment induced or de novo in origin?
Falini B
Leukemia. 2008
PubMed ID: 18478020
Cytoplasmic mutated nucleophosmin is stable in primary leukemic cells and in a xenotransplant model of NPMc+ acute myeloid leukemia in SCID mice.
Falini B, Martelli MP, Mecucci C, Liso A, Bolli N, Bigerna B, Pucciarini A, Pileri S, Meloni G, Martelli MF, Haferlach T, Schnittger S
Haematologica. 2008
PubMed ID: 18367491
Transcription regulation of the rRNA gene by a multifunctional nucleolar protein, B23/nucleophosmin, through its histone chaperone activity.
Murano K, Okuwaki M, Hisaoka M, Nagata K
Mol Cell Biol. 2008
PubMed ID: 18332108
NPM1 mutations in therapy-related acute myeloid leukemia with uncharacteristic features.
Andersen MT, Andersen MK, Christiansen DH, Pedersen-Bjergaard J
Leukemia. 2008
PubMed ID: 18273044
Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cell.
Léotoing L, Meunier L, Manin M, Mauduit C, Decaussin M, Verrijdt G, Claessens F, Benahmed M, Veyssière G, Morel L, Beaudoin C
Oncogene. 2008
PubMed ID: 18037965
Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD.
Hou HA, Chou WC, Lin LI, Chen CY, Tang JL, Tseng MH, Huang CF, Chiou RJ, Lee FY, Liu MC, Tien HF
Leukemia. 2008
PubMed ID: 17972951
Nucleophosmin interacts with HEXIM1 and regulates RNA polymerase II transcription.
Gurumurthy M, Tan CH, Ng R, Zeiger L, Lau J, Lee J, Dey A, Philp R, Li Q, Lim TM, Price DH, Lane DP, Chao SH
J Mol Biol. 2008
PubMed ID: 18371977
Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas.
Colomba A, Courilleau D, Ramel D, Billadeau DD, Espinos E, Delsol G, Payrastre B, Gaits-Iacovoni F
Oncogene. 2008
PubMed ID: 17998938
Binding to nucleophosmin determines the localization of human and chicken ARF but not its impact on p53.
Moulin S, Llanos S, Kim SH, Peters G
Oncogene. 2008
PubMed ID: 17968318
Lysine 263 residue of NPM/B23 is essential for regulating ATP binding and B23 stability.
Choi JW, Lee SB, Kim CK, Lee KH, Cho SW, Ahn JY
FEBS Lett. 2008
PubMed ID: 18319061
Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
Han G, Ye M, Zhou H, Jiang X, Feng S, Jiang X, Tian R, Wan D, Zou H, Gu J
Proteomics. 2008
PubMed ID: 18318008
Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse.
Sportoletti P, Grisendi S, Majid SM, Cheng K, Clohessy JG, Viale A, Teruya-Feldstein J, Pandolfi PP
Blood. 2008
PubMed ID: 18212245
The structure and functions of NPM1/Nucleophsmin/B23, a multifunctional nucleolar acidic protein.
Okuwaki M
J Biochem. 2008
PubMed ID: 18024471
Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin.
Garzon R, Garofalo M, Martelli MP, Briesewitz R, Wang L, Fernandez-Cymering C, Volinia S, Liu CG, Schnittger S, Haferlach T, Liso A, Diverio D, Mancini M, Meloni G, Foa R, Martelli MF, Mecucci C, Croce CM, Falini B
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18308931
DNA damage-dependent translocation of B23 and p19 ARF is regulated by the Jun N-terminal kinase pathway.
Yogev O, Saadon K, Anzi S, Inoue K, Shaulian E
Cancer Res. 2008
PubMed ID: 18316603
Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples.
Tsui KH, Juang HH, Lee TH, Chang PL, Chen CL, Yung BY
Acta Pharmacol Sin. 2008
PubMed ID: 18298902
NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia.
Falini B, Mecucci C, Saglio G, Lo Coco F, Diverio D, Brown P, Pane F, Mancini M, Martelli MP, Pileri S, Haferlach T, Haferlach C, Schnittger S
Haematologica. 2008
PubMed ID: 18268276
The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing.
Haindl M, Harasim T, Eick D, Muller S
EMBO Rep. 2008
PubMed ID: 18259216
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR
J Proteome Res. 2008
PubMed ID: 18220336
Characterisation of the Bax-nucleophosmin interaction: the importance of the Bax C-terminus.
Thompson J, Finlayson K, Salvo-Chirnside E, MacDonald D, McCulloch J, Kerr L, Sharkey J
Apoptosis. 2008
PubMed ID: 18214681
Topoisomerase IIbeta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistance.
McNamara S, Wang H, Hanna N, Miller WH
Mol Cell Biol. 2008
PubMed ID: 18212063
Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.
Sugimoto N, Kitabayashi I, Osano S, Tatsumi Y, Yugawa T, Narisawa-Saito M, Matsukage A, Kiyono T, Fujita M
Mol Biol Cell. 2008
PubMed ID: 18162579
Clinical impact of nucleophosmin mutations and Flt3 internal tandem duplications in patients older than 60 yr with acute myeloid leukaemia.
Scholl S, Theuer C, Scheble V, Kunert C, Heller A, Mügge LO, Fricke HJ, Höffken K, Wedding U
Eur J Haematol. 2008
PubMed ID: 18081718
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia.
Gale RE, Green C, Allen C, Mead AJ, Burnett AK, Hills RK, Linch DC, Medical Research Council Adult Leukaemia Working Party
Blood. 2008
PubMed ID: 17957027
Nucleophosmin/B23 negatively regulates GCN5-dependent histone acetylation and transactivation.
Zou Y, Wu J, Giannone RJ, Boucher L, Du H, Huang Y, Johnson DK, Liu Y, Wang Y
J Biol Chem. 2008
PubMed ID: 18165222
A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function.
Apicelli AJ, Maggi LB, Hirbe AC, Miceli AP, Olanich ME, Schulte-Winkeler CL, Saporita AJ, Kuchenreuther M, Sanchez J, Weilbaecher K, Weber JD
Mol Cell Biol. 2008
PubMed ID: 18070929
Release of angiopoietin-1 by primary human acute myelogenous leukemia cells is associated with mutations of nucleophosmin, increased by bone marrow stromal cells and possibly antagonized by high systemic angiopoietin-2 levels.
Hatfield KJ, Hovland R, Øyan AM, Kalland KH, Ryningen A, Gjertsen BT, Bruserud Ø
Leukemia. 2008
PubMed ID: 17943167
Nucleophosmin leukaemic mutants contain C-terminus peptides that bind HLA class I molecules.
Liso A, Colau D, Benmaamar R, De Groot A, Martin W, Benedetti R, Specchia G, Martelli MP, Coulie P, Falini B
Leukemia. 2008
PubMed ID: 17690700
Early pre-implantation lethality in mice carrying truncated mutation in the RNA polymerase 1-2 gene.
Chen H, Li Z, Haruna K, Li Z, Li Z, Semba K, Araki M, Yamamura K, Araki K
Biochem Biophys Res Commun. 2008
PubMed ID: 18023416
RBM19 is essential for preimplantation development in the mouse.
Zhang J, Tomasini AJ, Mayer AN
BMC Dev Biol. 2008
PubMed ID: 19087264
Ribosomal stress induces processing of Mybbp1a and its translocation from the nucleolus to the nucleoplasm.
Yamauchi T, Keough RA, Gonda TJ, Ishii S
Genes Cells. 2008
PubMed ID: 18173745
Absence of nucleophosmin leukaemic mutants in B and T cells from AML with NPM1 mutations: implications for the cell of origin of NPMc+ AML.
Martelli MP, Manes N, Pettirossi V, Liso A, Pacini R, Mannucci R, Zei T, Bolli N, di Raimondo F, Specchia G, Nicoletti I, Martelli MF, Falini B
Leukemia. 2008
PubMed ID: 17637812
Ebp1 association with nucleophosmin/B23 is essential for regulating cell proliferation and suppressing apoptosis.
Okada M, Jang SW, Ye K
J Biol Chem. 2007
PubMed ID: 17951246
Prognostic significance of FLT3 internal tandem duplication and NPM1 mutations in acute myeloid leukemia in an unselected patient population.
Suzuki R, Onizuka M, Kojima M, Shimada M, Okamura K, Fukagawa S, Tsuboi K, Kikuchi A, Kobayashi H, Shintani A, Ogawa Y, Kawada H, Hotta T, Ando K
Int J Hematol. 2007
PubMed ID: 18192111
Can probability of genetic mutation be an indicator of clinical relevance?
Chen CL, Tsui KH, Lin CY, Chang PL, Tang P, Yung BY
Genomics. 2007
PubMed ID: 17920239
The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence.
Cheng K, Grisendi S, Clohessy JG, Majid S, Bernardi R, Sportoletti P, Pandolfi PP
Oncogene. 2007
PubMed ID: 17546053
Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface.
Lee HH, Kim HS, Kang JY, Lee BI, Ha JY, Yoon HJ, Lim SO, Jung G, Suh SW
Proteins. 2007
PubMed ID: 17879352
[A study of NPM1 and FLT3 gene mutations in acute myeloid leukemia]
Wu DP, Yan LZ, Yang L, Chen SN, Wu XJ, Liang JY
Zhonghua Nei Ke Za Zhi. 2007
PubMed ID: 18261272
Lack of nucleophosmin mutation in patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities.
Shiseki M, Kitagawa Y, Wang YH, Yoshinaga K, Kondo T, Kuroiwa H, Okada M, Mori N, Motoji T
Leuk Lymphoma. 2007
PubMed ID: 17990177
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD
J Proteome Res. 2007
PubMed ID: 17924679
STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression.
Zhang Q, Wang HY, Liu X, Wasik MA
Nat Med. 2007
PubMed ID: 17922009
Association of nucleophosmin negatively regulates CXCR4-mediated G protein activation and chemotaxis.
Zhang W, Navenot JM, Frilot NM, Fujii N, Peiper SC
Mol Pharmacol. 2007
PubMed ID: 17715399
The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling.
Staber PB, Vesely P, Haq N, Ott RG, Funato K, Bambach I, Fuchs C, Schauer S, Linkesch W, Hrzenjak A, Dirks WG, Sexl V, Bergler H, Kadin ME, Sternberg DW, Kenner L, Hoefler G
Blood. 2007
PubMed ID: 17690253
Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration.
Strand AD, Baquet ZC, Aragaki AK, Holmans P, Yang L, Cleren C, Beal MF, Jones L, Kooperberg C, Olson JM, Jones KR
J Neurosci. 2007
PubMed ID: 17959817
Sustained expression of nucleophosmin (NPM1) mutation at late relapse presenting as isolated myeloid sarcoma in a patient with acute myeloid leukemia.
Scholl S, Lüftner J, Mügge LO, Schmidt V, Fricke HJ, Höffken K
Ann Hematol. 2007
PubMed ID: 17639390
NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphoma.
Galietta A, Gunby RH, Redaelli S, Stano P, Carniti C, Bachi A, Tucker PW, Tartari CJ, Huang CJ, Colombo E, Pulford K, Puttini M, Piazza RG, Ruchatz H, Villa A, Donella-Deana A, Marin O, Perrotti D, Gambacorti-Passerini C
Blood. 2007
PubMed ID: 17537995
NPM1 mutations are more stable than FLT3 mutations during the course of disease in patients with acute myeloid leukemia.
Palmisano M, Grafone T, Ottaviani E, Testoni N, Baccarani M, Martinelli G
Haematologica. 2007
PubMed ID: 17768124
Aberrant cytoplasmic expression of C-terminal-truncated NPM leukaemic mutant is dictated by tryptophans loss and a new NES motif.
Falini B, Albiero E, Bolli N, De Marco MF, Madeo D, Martelli M, Nicoletti I, Rodeghiero F
Leukemia. 2007
PubMed ID: 17637816
Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias.
Mullighan CG, Kennedy A, Zhou X, Radtke I, Phillips LA, Shurtleff SA, Downing JR
Leukemia. 2007
PubMed ID: 17597811
The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA.
Ganapathi KA, Austin KM, Lee CS, Dias A, Malsch MM, Reed R, Shimamura A
Blood. 2007
PubMed ID: 17475909
Rapid screening and sensitive detection of NPM1 (nucleophosmin) exon 12 mutations in acute myeloid leukaemia.
Scholl S, Mügge LO, Landt O, Loncarevic IF, Kunert C, Clement JH, Höffken K
Leuk Res. 2007
PubMed ID: 17306368
Analysis of NPM1 gene mutations in Chinese adults with acute myeloid leukemia.
Yan L, Chen S, Liang J, Feng Y, Cen J, He J, Chang W, Zhu Z, Pan J, Wu Y, Xue Y, Wu D
Int J Hematol. 2007
PubMed ID: 17875528
The incidence and clinical significance of nucleophosmin mutations in childhood AML.
Brown P, McIntyre E, Rau R, Meshinchi S, Lacayo N, Dahl G, Alonzo TA, Chang M, Arceci RJ, Small D
Blood. 2007
PubMed ID: 17440048
Physical and functional interaction between a nucleolar protein nucleophosmin/B23 and adenovirus basic core proteins.
Samad MA, Okuwaki M, Haruki H, Nagata K
FEBS Lett. 2007
PubMed ID: 17602943
Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants.
Bolli N, Nicoletti I, De Marco MF, Bigerna B, Pucciarini A, Mannucci R, Martelli MP, Liso A, Mecucci C, Fabbiano F, Martelli MF, Henderson BR, Falini B
Cancer Res. 2007
PubMed ID: 17616680
Distinctive expression of myelomonocytic markers and down-regulation of CD34 in acute myelogenous leukaemia with FLT3 tandem duplication and nucleophosmin mutation.
Mori Y, Yoshimoto G, Kumano T, Miyamoto T, Iino T, Takenaka K, Iwasaki H, Harada N, Kinukawa N, Nagafuji K, Teshima T, Shimoda K, Akashi K, Harada M
Eur J Haematol. 2007
PubMed ID: 17598835
PAI-1 induces cell detachment, downregulates nucleophosmin (B23) and fortilin (TCTP) in LnCAP prostate cancer cells.
Jankun J, Aleem AM, Specht Z, Keck RW, Lysiak-Szydlowska W, Selman SH, Skrzypczak-Jankun E
Int J Mol Med. 2007
PubMed ID: 17549383
A new type of NPM1 gene mutation in AML leading to a C-terminal truncated protein.
Pitiot AS, Santamaría I, García-Suárez O, Centeno I, Astudillo A, Rayón C, Balbín M
Leukemia. 2007
PubMed ID: 17410190
Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival.
Liu X, Liu Z, Jang SW, Ma Z, Shinmura K, Kang S, Dong S, Chen J, Fukasawa K, Ye K
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17535915
No nucleophosmin mutations in pediatric acute myeloid leukemia with normal karyotype: a study of the Japanese Childhood AML Cooperative Study Group.
Shimada A, Taki T, Kubota C, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y
Leukemia. 2007
PubMed ID: 17315018
Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability.
Li J, Sejas DP, Burma S, Chen DJ, Pang Q
Carcinogenesis. 2007
PubMed ID: 17277230
Alteration of nuclear matrix-intermediate filament system and differential expression of nuclear matrix proteins during human hepatocarcinoma cell differentiation.
Tang J, Niu JW, Xu DH, Li ZX, Li QF, Chen JA
World J Gastroenterol. 2007
PubMed ID: 17569113
[Analysis of NPM1 gene mutations in acute myeloid leukemia]
Yan LZ, Chen SN, Liang JY, Feng YF, Cen JN, He J, Chang WR, Zhu ZL, Pan JL, Wu YF, Xue YQ, Wu DP
Zhonghua Xue Ye Xue Za Zhi. 2007
PubMed ID: 17877154
Detection and identification of transcription factors as interaction partners of alien in vivo.
Kob R, Baniahmad A, Escher N, von Eggeling F, Melle C
Cell Cycle. 2007
PubMed ID: 17438371
Absence of nucleophosmin 1 (NPM1) gene mutations in common solid cancers.
Jeong EG, Lee SH, Yoo NJ, Lee SH
APMIS. 2007
PubMed ID: 17504301
Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias.
Falini B, Nicoletti I, Bolli N, Martelli MP, Liso A, Gorello P, Mandelli F, Mecucci C, Martelli MF
Haematologica. 2007
PubMed ID: 17488663
Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation.
Liu H, Tan BC, Tseng KH, Chuang CP, Yeh CW, Chen KD, Lee SC, Yung BY
EMBO Rep. 2007
PubMed ID: 17318229
Aurora-B regulates RNA methyltransferase NSUN2.
Sakita-Suto S, Kanda A, Suzuki F, Sato S, Takata T, Tatsuka M
Mol Biol Cell. 2007
PubMed ID: 17215513
Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.
Molina H, Horn DM, Tang N, Mathivanan S, Pandey A
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17287340
Different types of NPM1 mutations in children and adults: evidence for an effect of patient age on the prevalence of the TCTG-tandem duplication in NPM1-exon 12.
Thiede C, Creutzig E, Reinhardt D, Ehninger G, Creutzig U
Leukemia. 2007
PubMed ID: 17151698
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.
Dai J, Jin WH, Sheng QH, Shieh CH, Wu JR, Zeng R
J Proteome Res. 2007
PubMed ID: 17203969
NPM1 mutations in myelodysplastic syndromes and acute myeloid leukemia with normal karyotype.
Zhang Y, Zhang M, Yang L, Xiao Z
Leuk Res. 2007
PubMed ID: 16678898
Multiple controls regulate nucleostemin partitioning between nucleolus and nucleoplasm.
Meng L, Yasumoto H, Tsai RY
J Cell Sci. 2006
PubMed ID: 17158916
Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication.
Ma Z, Kanai M, Kawamura K, Kaibuchi K, Ye K, Fukasawa K
Mol Cell Biol. 2006
PubMed ID: 17015463
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Nucleophosmin gene mutations in acute myeloid leukemia.
Chen W, Rassidakis GZ, Medeiros LJ
Arch Pathol Lab Med. 2006
PubMed ID: 17076533
Implication of nucleolar protein SURF6 in ribosome biogenesis and preimplantation mouse development.
Romanova LG, Anger M, Zatsepina OV, Schultz RM
Biol Reprod. 2006
PubMed ID: 16855206
Nucleophosmin/B23 regulates transcriptional activation of E2F1 via modulating the promoter binding of NF-kappaB, E2F1 and pRB.
Lin CY, Liang YC, Yung BY
Cell Signal. 2006
PubMed ID: 16725311
A "liaison dangereuse" between AUF1/hnRNPD and the oncogenic tyrosine kinase NPM-ALK.
Fawal M, Armstrong F, Ollier S, Dupont H, Touriol C, Monsarrat B, Delsol G, Payrastre B, Morello D
Blood. 2006
PubMed ID: 16835382
Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma.
Han Y, Amin HM, Franko B, Frantz C, Shi X, Lai R
Blood. 2006
PubMed ID: 16825495
Ras-dependent recruitment of c-Myc for transcriptional activation of nucleophosmin/B23 in highly malignant U1 bladder cancer cells.
Yeh CW, Huang SS, Lee RP, Yung BY
Mol Pharmacol. 2006
PubMed ID: 16857742
Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia.
Falini B, Martelli MP, Bolli N, Bonasso R, Ghia E, Pallotta MT, Diverio D, Nicoletti I, Pacini R, Tabarrini A, Galletti BV, Mannucci R, Roti G, Rosati R, Specchia G, Liso A, Tiacci E, Alcalay M, Luzi L, Volorio S, Bernard L, Guarini A, Amadori S, Mandelli F, Pane F, Lo-Coco F, Saglio G, Pelicci PG, Martelli MF, Mecucci C
Blood. 2006
PubMed ID: 16720834
NPM-ALK-dependent expression of the transcription factor CCAAT/enhancer binding protein beta in ALK-positive anaplastic large cell lymphoma.
Quintanilla-Martinez L, Pittaluga S, Miething C, Klier M, Rudelius M, Davies-Hill T, Anastasov N, Martinez A, Vivero A, Duyster J, Jaffe ES, Fend F, Raffeld M
Blood. 2006
PubMed ID: 16709933
Inducible and reversible suppression of Npm1 gene expression using stably integrated small interfering RNA vector in mouse embryonic stem cells.
Wang BB, Lu R, Wang WC, Jin Y
Biochem Biophys Res Commun. 2006
PubMed ID: 16870143
High frequency of NPM1 gene mutations in acute myeloid leukemia with prominent nuclear invaginations ("cuplike" nuclei).
Chen W, Rassidakis GZ, Li J, Routbort M, Jones D, Kantarjian H, Medeiros LJ, Bueso-Ramos CE
Blood. 2006
PubMed ID: 16926303
Effects of interphase and mitotic phosphorylation on the mobility and location of nucleolar protein B23.
Negi SS, Olson MO
J Cell Sci. 2006
PubMed ID: 16912078
DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer.
Gjerset RA
J Mol Histol. 2006
PubMed ID: 16855788
Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression.
Dhar SK, Xu Y, Chen Y, St Clair DK
J Biol Chem. 2006
PubMed ID: 16740634
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y
Mol Cell. 2006
PubMed ID: 16916647
Mutations and promoter methylation status of NPM1 in myeloproliferative disorders.
Oki Y, Jelinek J, Beran M, Verstovsek S, Kantarjian HM, Issa JP
Haematologica. 2006
PubMed ID: 16870548
Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs.
Zou T, Mazan-Mamczarz K, Rao JN, Liu L, Marasa BS, Zhang AH, Xiao L, Pullmann R, Gorospe M, Wang JY
J Biol Chem. 2006
PubMed ID: 16690610
Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability.
Enomoto T, Lindström MS, Jin A, Ke H, Zhang Y
J Biol Chem. 2006
PubMed ID: 16679321
[Study of nucleophosmin (NPM) gene mutation in patients with acute myeloid leukemia and myelodysplastic syndromes]
Zhang Y, Zhang MR, Yang L, Xiao ZJ
Zhonghua Xue Ye Xue Za Zhi. 2006
PubMed ID: 17147251
Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3.
Kasprzycka M, Marzec M, Liu X, Zhang Q, Wasik MA
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16766651
Nucleophosmin regulates cell cycle progression and stress response in hematopoietic stem/progenitor cells.
Li J, Sejas DP, Rani R, Koretsky T, Bagby GC, Pang Q
J Biol Chem. 2006
PubMed ID: 16608843
Quantitative assessment of minimal residual disease in acute myeloid leukemia carrying nucleophosmin (NPM1) gene mutations.
Gorello P, Cazzaniga G, Alberti F, Dell'Oro MG, Gottardi E, Specchia G, Roti G, Rosati R, Martelli MF, Diverio D, Lo Coco F, Biondi A, Saglio G, Mecucci C, Falini B
Leukemia. 2006
PubMed ID: 16541144
The dynamic alterations of H2AX complex during DNA repair detected by a proteomic approach reveal the critical roles of Ca(2+)/calmodulin in the ionizing radiation-induced cell cycle arrest.
Du YC, Gu S, Zhou J, Wang T, Cai H, Macinnes MA, Bradbury EM, Chen X
Mol Cell Proteomics. 2006
PubMed ID: 16522924
Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.
Falini B, Bolli N, Shan J, Martelli MP, Liso A, Pucciarini A, Bigerna B, Pasqualucci L, Mannucci R, Rosati R, Gorello P, Diverio D, Roti G, Tiacci E, Cazzaniga G, Biondi A, Schnittger S, Haferlach T, Hiddemann W, Martelli MF, Gu W, Mecucci C, Nicoletti I
Blood. 2006
PubMed ID: 16455950
Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).
Thiede C, Koch S, Creutzig E, Steudel C, Illmer T, Schaich M, Ehninger G
Blood. 2006
PubMed ID: 16455956
Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.
Hoffert JD, Pisitkun T, Wang G, Shen RF, Knepper MA
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16641100
Nucleophosmin is essential for ribosomal protein L5 nuclear export.
Yu Y, Maggi LB, Brady SN, Apicelli AJ, Dai MS, Lu H, Weber JD
Mol Cell Biol. 2006
PubMed ID: 16648475
Denaturing high-performance liquid chromatography: a valid approach for identifying NPM1 mutations in acute myeloid leukemia.
Roti G, Rosati R, Bonasso R, Gorello P, Diverio D, Martelli MF, Falini B, Mecucci C, Gruppo Italiano Malattie Ematologiche dell' Adulto Working Party
J Mol Diagn. 2006
PubMed ID: 16645213
Comprehensive identification of phosphorylation sites in postsynaptic density preparations.
Trinidad JC, Specht CG, Thalhammer A, Schoepfer R, Burlingame AL
Mol Cell Proteomics. 2006
PubMed ID: 16452087
Phosphoproteome analysis of the human mitotic spindle.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16565220
Proteomic analysis of macrophages stimulated by lipopolysaccharide: Lipopolysaccharide inhibits the cleavage of nucleophosmin.
Zhang X, Kuramitsu Y, Fujimoto M, Hayashi E, Yuan X, Nakamura K
Electrophoresis. 2006
PubMed ID: 16609939
Cytoplasmic nucleophosmin in myeloid sarcoma occurring 20 years after diagnosis of acute myeloid leukaemia.
Bolli N, Galimberti S, Martelli MP, Tabarrini A, Roti G, Mecucci C, Martelli MF, Petrini M, Falini B
Lancet Oncol. 2006
PubMed ID: 16574551
Requirement of the protein B23 for nucleolar disassembly induced by the FRGY2a family proteins.
Gonda K, Wudel J, Nelson D, Katoku-Kikyo N, Reed P, Tamada H, Kikyo N
J Biol Chem. 2006
PubMed ID: 16415342
The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6.
Sgarra R, Lee J, Tessari MA, Altamura S, Spolaore B, Giancotti V, Bedford MT, Manfioletti G
J Biol Chem. 2006
PubMed ID: 16293633
Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing.
Tarapore P, Shinmura K, Suzuki H, Tokuyama Y, Kim SH, Mayeda A, Fukasawa K
FEBS Lett. 2006
PubMed ID: 16376875
Hepatitis C virus core protein recruits nucleolar phosphoprotein B23 and coactivator p300 to relieve the repression effect of transcriptional factor YY1 on B23 gene expression.
Mai RT, Yeh TS, Kao CF, Sun SK, Huang HH, Wu Lee YH
Oncogene. 2006
PubMed ID: 16170350
Characterisation of the interface between nucleophosmin (NPM) and p53: potential role in p53 stabilisation.
Lambert B, Buckle M
FEBS Lett. 2006
PubMed ID: 16376884
Nucleolar protein B23 interacts with Japanese encephalitis virus core protein and participates in viral replication.
Tsuda Y, Mori Y, Abe T, Yamashita T, Okamoto T, Ichimura T, Moriishi K, Matsuura Y
Microbiol Immunol. 2006
PubMed ID: 16547420
Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity.
Shinmura K, Tarapore P, Tokuyama Y, George KR, Fukasawa K
FEBS Lett. 2005
PubMed ID: 16297385
Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype.
Schnittger S, Schoch C, Kern W, Mecucci C, Tschulik C, Martelli MF, Haferlach T, Hiddemann W, Falini B
Blood. 2005
PubMed ID: 16076867
Rbm19 is a nucleolar protein expressed in crypt/progenitor cells of the intestinal epithelium.
Lorenzen JA, Bonacci BB, Palmer RE, Wells C, Zhang J, Haber DA, Goldstein AM, Mayer AN
Gene Expr Patterns. 2005
PubMed ID: 16027046
Negative regulation of p53 by nucleophosmin antagonizes stress-induced apoptosis in human normal and malignant hematopoietic cells.
Li J, Zhang X, Sejas DP, Pang Q
Leuk Res. 2005
PubMed ID: 15964625
Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype.
Boissel N, Renneville A, Biggio V, Philippe N, Thomas X, Cayuela JM, Terre C, Tigaud I, Castaigne S, Raffoux E, De Botton S, Fenaux P, Dombret H, Preudhomme C
Blood. 2005
PubMed ID: 16046528
Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.
Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY
Cell Res. 2005
PubMed ID: 16354571
Myeloid leukemia-associated nucleophosmin mutants perturb p53-dependent and independent activities of the Arf tumor suppressor protein.
den Besten W, Kuo ML, Williams RT, Sherr CJ
Cell Cycle. 2005
PubMed ID: 16205118
Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia.
Suzuki T, Kiyoi H, Ozeki K, Tomita A, Yamaji S, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Ueda R, Kinoshita T, Emi N, Naoe T
Blood. 2005
PubMed ID: 15994285
Nucleophosmin is required for DNA integrity and p19Arf protein stability.
Colombo E, Bonetti P, Lazzerini Denchi E, Martinelli P, Zamponi R, Marine JC, Helin K, Falini B, Pelicci PG
Mol Cell Biol. 2005
PubMed ID: 16199867
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B
Proteomics. 2005
PubMed ID: 16130169
Nucleophosmin/B23 regulates PCNA promoter through YY1.
Weng JJ, Yung BY
Biochem Biophys Res Commun. 2005
PubMed ID: 16099430
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription.
Swaminathan V, Kishore AH, Febitha KK, Kundu TK
Mol Cell Biol. 2005
PubMed ID: 16107701
Role of nucleophosmin in embryonic development and tumorigenesis.
Grisendi S, Bernardi R, Rossi M, Cheng K, Khandker L, Manova K, Pandolfi PP
Nature. 2005
PubMed ID: 16007073
Polyamine depletion induces nucleophosmin modulating stability and transcriptional activity of p53 in intestinal epithelial cells.
Zou T, Rao JN, Liu L, Marasa BS, Keledjian KM, Zhang AH, Xiao L, Bass BL, Wang JY
Am J Physiol Cell Physiol. 2005
PubMed ID: 15872011
Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype.
Cazzaniga G, Dell'Oro MG, Mecucci C, Giarin E, Masetti R, Rossi V, Locatelli F, Martelli MF, Basso G, Pession A, Biondi A, Falini B
Blood. 2005
PubMed ID: 15870172
Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication.
Wang W, Budhu A, Forgues M, Wang XW
Nat Cell Biol. 2005
PubMed ID: 16041368
Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia.
Noguera NI, Ammatuna E, Zangrilli D, Lavorgna S, Divona M, Buccisano F, Amadori S, Mecucci C, Falini B, Lo-Coco F
Leukemia. 2005
PubMed ID: 15973451
Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance.
Alcalay M, Tiacci E, Bergomas R, Bigerna B, Venturini E, Minardi SP, Meani N, Diverio D, Bernard L, Tizzoni L, Volorio S, Luzi L, Colombo E, Lo Coco F, Mecucci C, Falini B, Pelicci PG
Blood. 2005
PubMed ID: 15831697
Global phosphoproteome of HT-29 human colon adenocarcinoma cells.
Kim JE, Tannenbaum SR, White FM
J Proteome Res. 2005
PubMed ID: 16083285
Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis.
Yuan X, Zhou Y, Casanova E, Chai M, Kiss E, Gröne HJ, Schütz G, Grummt I
Mol Cell. 2005
PubMed ID: 15989966
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.
Chen D, Kon N, Li M, Zhang W, Qin J, Gu W
Cell. 2005
PubMed ID: 15989956
c-Myc-regulated microRNAs modulate E2F1 expression.
O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT
Nature. 2005
PubMed ID: 15944709
B23 is a downstream target of polyamine-modulated CK2.
Lawson K, Larentowicz L, Laury-Kleintop L, Gilmour SK
Mol Cell Biochem. 2005
PubMed ID: 16342411
[Cloning and structural analysis of mouse genomic nucleophosmin gene]
Xiang YG, Lu SY, Gu MM, Wang SY, Ren SX, Fu G, Wang ZG
Yi Chuan Xue Bao. 2005
PubMed ID: 16018192
Sumoylation induced by the Arf tumor suppressor: a p53-independent function.
Tago K, Chiocca S, Sherr CJ
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15897463
Proteomic analysis of complexes formed by human topoisomerase I.
Czubaty A, Girstun A, Kowalska-Loth B, Trzcińska AM, Purta E, Winczura A, Grajkowski W, Staroń K
Biochim Biophys Acta. 2005
PubMed ID: 15848144
Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD.
Ahn JY, Liu X, Cheng D, Peng J, Chan PK, Wade PA, Ye K
Mol Cell. 2005
PubMed ID: 15893727
RPGR ORF15 isoform co-localizes with RPGRIP1 at centrioles and basal bodies and interacts with nucleophosmin.
Shu X, Fry AM, Tulloch B, Manson FD, Crabb JW, Khanna H, Faragher AJ, Lennon A, He S, Trojan P, Giessl A, Wolfrum U, Vervoort R, Swaroop A, Wright AF
Hum Mol Genet. 2005
PubMed ID: 15772089
B23 regulates GADD45a nuclear translocation and contributes to GADD45a-induced cell cycle G2-M arrest.
Gao H, Jin S, Song Y, Fu M, Wang M, Liu Z, Wu M, Zhan Q
J Biol Chem. 2005
PubMed ID: 15644315
PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts.
Cairo S, De Falco F, Pizzo M, Salomoni P, Pandolfi PP, Meroni G
Oncogene. 2005
PubMed ID: 15735755
Release of nucleophosmin from the nucleus: Involvement in aloe-emodin-induced human lung non small carcinoma cell apoptosis.
Lee HZ, Wu CH, Chang SP
Int J Cancer. 2005
PubMed ID: 15514966
Protein NPM3 interacts with the multifunctional nucleolar protein B23/nucleophosmin and inhibits ribosome biogenesis.
Huang N, Negi S, Szebeni A, Olson MO
J Biol Chem. 2005
PubMed ID: 15596447
Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function.
Korgaonkar C, Hagen J, Tompkins V, Frazier AA, Allamargot C, Quelle FW, Quelle DE
Mol Cell Biol. 2005
PubMed ID: 15684379
NPM mutations in acute myelogenous leukemia.
Grisendi S, Pandolfi PP
N Engl J Med. 2005
PubMed ID: 15659732
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG, Martelli MF, GIMEMA Acute Leukemia Working Party
N Engl J Med. 2005
PubMed ID: 15659725
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2.
Hayami R, Sato K, Wu W, Nishikawa T, Hiroi J, Ohtani-Kaneko R, Fukuda M, Ohta T
Cancer Res. 2005
PubMed ID: 15665273
PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli.
Meder VS, Boeglin M, de Murcia G, Schreiber V
J Cell Sci. 2005
PubMed ID: 15615785
Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway.
Ju BG, Solum D, Song EJ, Lee KJ, Rose DW, Glass CK, Rosenfeld MG
Cell. 2004
PubMed ID: 15607978
c-Myc-mediated expression of nucleophosmin/B23 decreases during retinoic acid-induced differentiation of human leukemia HL-60 cells.
Yung BY
FEBS Lett. 2004
PubMed ID: 15589822
ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway.
Brady SN, Yu Y, Maggi LB, Weber JD
Mol Cell Biol. 2004
PubMed ID: 15485902
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo.
Lin KT, Lu RM, Tarn WY
Mol Cell Biol. 2004
PubMed ID: 15456888
Hypoxia-induced nucleophosmin protects cell death through inhibition of p53.
Li J, Zhang X, Sejas DP, Bagby GC, Pang Q
J Biol Chem. 2004
PubMed ID: 15310764
Nek2A kinase regulates the localization of numatrin to centrosome in mitosis.
Yao J, Fu C, Ding X, Guo Z, Zenreski A, Chen Y, Ahmed K, Liao J, Dou Z, Yao X
FEBS Lett. 2004
PubMed ID: 15388344
The DNA sequence and comparative analysis of human chromosome 5.
Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM
Nature. 2004
PubMed ID: 15372022
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S
Genome Res. 2004
PubMed ID: 15342556
MEK inhibition and phosphorylation of serine 4 on B23 are two coincident events in mitosis.
Hayne C, Xiang X, Luo Z
Biochem Biophys Res Commun. 2004
PubMed ID: 15358159
B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1.
Zhang H, Shi X, Paddon H, Hampong M, Dai W, Pelech S
J Biol Chem. 2004
PubMed ID: 15190079
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
Meek SE, Lane WS, Piwnica-Worms H
J Biol Chem. 2004
PubMed ID: 15161933
Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase.
Sato K, Hayami R, Wu W, Nishikawa T, Nishikawa H, Okuda Y, Ogata H, Fukuda M, Ohta T
J Biol Chem. 2004
PubMed ID: 15184379
Identification of nucleophosmin as an NF-kappaB co-activator for the induction of the human SOD2 gene.
Dhar SK, Lynn BC, Daosukho C, St Clair DK
J Biol Chem. 2004
PubMed ID: 15087454
Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation.
Kurki S, Peltonen K, Latonen L, Kiviharju TM, Ojala PM, Meek D, Laiho M
Cancer Cell. 2004
PubMed ID: 15144954
Nucleophosmin sets a threshold for p53 response to UV radiation.
Maiguel DA, Jones L, Chakravarty D, Yang C, Carrier F
Mol Cell Biol. 2004
PubMed ID: 15082766
Identification of NPM-ALK interacting proteins by tandem mass spectrometry.
Crockett DK, Lin Z, Elenitoba-Johnson KS, Lim MS
Oncogene. 2004
PubMed ID: 14968112
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
Analysis of proteins copurifying with the CD4/lck complex using one-dimensional polyacrylamide gel electrophoresis and mass spectrometry: comparison with affinity-tag based protein detection and evaluation of different solubilization methods.
Bernhard OK, Cunningham AL, Sheil MM
J Am Soc Mass Spectrom. 2004
PubMed ID: 15047060
Bcl-XL down-regulation suppresses the tumorigenic potential of NPM/ALK in vitro and in vivo.
Coluccia AM, Perego S, Cleris L, Gunby RH, Passoni L, Marchesi E, Formelli F, Gambacorti-Passerini C
Blood. 2004
PubMed ID: 14656879
A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain.
García-Frigola C, Burgaya F, Calbet M, López-Domènech G, de Lecea L, Soriano E
Brain Res Mol Brain Res. 2004
PubMed ID: 15010206
Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.
Shu H, Chen S, Bi Q, Mumby M, Brekken DL
Mol Cell Proteomics. 2004
PubMed ID: 14729942
Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity.
Cussac D, Greenland C, Roche S, Bai RY, Duyster J, Morris SW, Delsol G, Allouche M, Payrastre B
Blood. 2004
PubMed ID: 14563642
CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species.
Yusufzai TM, Tagami H, Nakatani Y, Felsenfeld G
Mol Cell. 2004
PubMed ID: 14759373
Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: insights into the association of specific autoantibodies with distinct disease phenotypes.
Ulanet DB, Flavahan NA, Casciola-Rosen L, Rosen A
Arthritis Rheum. 2004
PubMed ID: 14730621
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.
Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI
Dev Biol. 2003
PubMed ID: 14651920
Nucleophosmin/B23 is a proliferate shuttle protein associated with nuclear matrix.
Yun JP, Chew EC, Liew CT, Chan JY, Jin ML, Ding MX, Fai YH, Li HK, Liang XM, Wu QL
J Cell Biochem. 2003
PubMed ID: 14635188
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.
Itahana K, Bhat KP, Jin A, Itahana Y, Hawke D, Kobayashi R, Zhang Y
Mol Cell. 2003
PubMed ID: 14636574
Regulation of alternative splicing by SRrp86 and its interacting proteins.
Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG
Mol Cell Biol. 2003
PubMed ID: 14559993
Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR.
Pang Q, Christianson TA, Koretsky T, Carlson H, David L, Keeble W, Faulkner GR, Speckhart A, Bagby GC
J Biol Chem. 2003
PubMed ID: 12882984
Unique conformation of cancer autoantigen B23 in hepatoma: a mechanism for specificity in the autoimmune response.
Ulanet DB, Torbenson M, Dang CV, Casciola-Rosen L, Rosen A
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14519847
Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome.
Hayano T, Yanagida M, Yamauchi Y, Shinkawa T, Isobe T, Takahashi N
J Biol Chem. 2003
PubMed ID: 12777385
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).
Ouyang T, Bai RY, Bassermann F, von Klitzing C, Klumpen S, Miething C, Morris SW, Peschel C, Duyster J
J Biol Chem. 2003
PubMed ID: 12748172
Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia.
Arber DA, Chang KL, Lyda MH, Bedell V, Spielberger R, Slovak ML
Hum Pathol. 2003
PubMed ID: 14506644
Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos.
Burns KH, Viveiros MM, Ren Y, Wang P, DeMayo FJ, Frail DE, Eppig JJ, Matzuk MM
Science. 2003
PubMed ID: 12714744
Role of protein kinase CK2 phosphorylation in the molecular chaperone activity of nucleolar protein b23.
Szebeni A, Hingorani K, Negi S, Olson MO
J Biol Chem. 2003
PubMed ID: 12511551
Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice.
Lange K, Uckert W, Blankenstein T, Nadrowitz R, Bittner C, Renauld JC, van Snick J, Feller AC, Merz H
Oncogene. 2003
PubMed ID: 12555065
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
UV stimulation of nucleophosmin/B23 expression is an immediate-early gene response induced by damaged DNA.
Wu MH, Yung BY
J Biol Chem. 2002
PubMed ID: 12374805
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells.
Tsai RY, McKay RD
Genes Dev. 2002
PubMed ID: 12464630
Functional proteomic analysis of human nucleolus.
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ
Mol Biol Cell. 2002
PubMed ID: 12429849
Tryptophans 286 and 288 in the C-terminal region of protein B23.1 are important for its nucleolar localization.
Nishimura Y, Ohkubo T, Furuichi Y, Umekawa H
Biosci Biotechnol Biochem. 2002
PubMed ID: 12450141
The role of nucleophosmin in centrosome duplication.
Okuda M
Oncogene. 2002
PubMed ID: 12214246
Increased expression of a COOH-truncated nucleophosmin resulting from alternative splicing is associated with cellular resistance to ionizing radiation in HeLa cells.
Dalenc F, Drouet J, Ader I, Delmas C, Rochaix P, Favre G, Cohen-Jonathan E, Toulas C
Int J Cancer. 2002
PubMed ID: 12209603
Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.
Qi C, Chang J, Zhu Y, Yeldandi AV, Rao SM, Zhu YJ
J Biol Chem. 2002
PubMed ID: 12039952
A major nucleolar protein B23 as a marker of proliferation activity of human peripheral lymphocytes.
Dergunova NN, Bulycheva TI, Artemenko EG, Shpakova AP, Pegova AN, Gemjian EG, Dudnik OA, Zatsepina OV, Malashenko OS
Immunol Lett. 2002
PubMed ID: 12057857
Nucleophosmin regulates the stability and transcriptional activity of p53.
Colombo E, Marine JC, Danovi D, Falini B, Pelicci PG
Nat Cell Biol. 2002
PubMed ID: 12080348
The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype.
Okuwaki M, Tsujimoto M, Nagata K
Mol Biol Cell. 2002
PubMed ID: 12058066
Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.
Larramendy ML, Niini T, Elonen E, Nagy B, Ollila J, Vihinen M, Knuutila S
Haematologica. 2002
PubMed ID: 12031912
The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer.
Dai YS, Cserjesi P
J Biol Chem. 2002
PubMed ID: 11812799
Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin.
Bonvini P, Gastaldi T, Falini B, Rosolen A
Cancer Res. 2002
PubMed ID: 11888936
Directed proteomic analysis of the human nucleolus.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI
Curr Biol. 2002
PubMed ID: 11790298
A mammalian in vitro centriole duplication system: evidence for involvement of CDK2/cyclin E and nucleophosmin/B23 in centrosome duplication.
Tarapore P, Okuda M, Fukasawa K
Cell Cycle. 2002
PubMed ID: 12429912
Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone.
Okuwaki M, Matsumoto K, Tsujimoto M, Nagata K
FEBS Lett. 2001
PubMed ID: 11602260
The carboxyl terminal sequence of nucleolar protein B23.1 is important in its DNA polymerase alpha-stimulatory activity.
Umekawa H, Sato K, Takemura M, Watanabe Y, Usui S, Takahashi T, Yoshida S, Olson MO, Furuichi Y
J Biochem. 2001
PubMed ID: 11481036
The nucleolar phosphoprotein B23 interacts with hepatitis delta antigens and modulates the hepatitis delta virus RNA replication.
Huang WH, Yung BY, Syu WJ, Lee YH
J Biol Chem. 2001
PubMed ID: 11309377
Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.
Tokuyama Y, Horn HF, Kawamura K, Tarapore P, Fukasawa K
J Biol Chem. 2001
PubMed ID: 11278991
Diverged nuclear localization of Werner helicase in human and mouse cells.
Suzuki T, Shiratori M, Furuichi Y, Matsumoto T
Oncogene. 2001
PubMed ID: 11420665
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Anaplastic large cell lymphoma with the t(2;5)(p23;q35) NPM/ALK chromosomal translocation and duplication of the short arm of the non-translocated chromosome 2 involving the full length of the ALK gene.
Greenland C, Dastugue N, Touriol C, Lamant L, Delsol G, Brousset P
J Clin Pathol. 2001
PubMed ID: 11215285
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication.
Okuda M, Horn HF, Tarapore P, Tokuyama Y, Smulian AG, Chan PK, Knudsen ES, Hofmann IA, Snyder JD, Bove KE, Fukasawa K
Cell. 2000
PubMed ID: 11051553
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
cDNA subtraction cloning reveals novel genes whose temporal and spatial expression indicates association with trophoblast invasion.
Hemberger M, Himmelbauer H, Ruschmann J, Zeitz C, Fundele R
Dev Biol. 2000
PubMed ID: 10885754
A method to identify cDNAs based on localization of green fluorescent protein fusion products.
Misawa K, Nosaka T, Morita S, Kaneko A, Nakahata T, Asano S, Kitamura T
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10716735
In vivo interaction of nucleophosmin/B23 and protein C23 during cell cycle progression in HeLa cells.
Liu HT, Yung BY
Cancer Lett. 1999
PubMed ID: 10503877
Nucleolar protein B23 has molecular chaperone activities.
Szebeni A, Olson MO
Protein Sci. 1999
PubMed ID: 10211837
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity.
Bai RY, Dieter P, Peschel C, Morris SW, Duyster J
Mol Cell Biol. 1998
PubMed ID: 9819383
Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Ko MS, Threat TA, Wang X, Horton JH, Cui Y, Wang X, Pryor E, Paris J, Wells-Smith J, Kitchen JR, Rowe LB, Eppig J, Satoh T, Brant L, Fujiwara H, Yotsumoto S, Nakashima H
Hum Mol Genet. 1998
PubMed ID: 9811942
The cryptic inv(2)(p23q35) defines a new molecular genetic subtype of ALK-positive anaplastic large-cell lymphoma.
Wlodarska I, De Wolf-Peeters C, Falini B, Verhoef G, Morris SW, Hagemeijer A, Van den Berghe H
Blood. 1998
PubMed ID: 9763551
A B-cell-specific DNA recombination complex.
Borggrefe T, Wabl M, Akhmedov AT, Jessberger R
J Biol Chem. 1998
PubMed ID: 9642267
The SURF-6 protein is a component of the nucleolar matrix and has a high binding capacity for nucleic acids in vitro.
Magoulas C, Zatsepina OV, Jordan PW, Jordan EG, Fried M
Eur J Cell Biol. 1998
PubMed ID: 9548374
Protein B23 is an important human factor for the nucleolar localization of the human immunodeficiency virus protein Tat.
Li YP
J Virol. 1997
PubMed ID: 9094689
Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis.
Bischof D, Pulford K, Mason DY, Morris SW
Mol Cell Biol. 1997
PubMed ID: 9121481
Nucleolar protein B23 stimulates nuclear import of the HIV-1 Rev protein and NLS-conjugated albumin.
Szebeni A, Mehrotra B, Baumann A, Adam SA, Wingfield PT, Olson MO
Biochemistry. 1997
PubMed ID: 9092824
Isolation and characterization of the human nucleophosmin/B23 (NPM) gene: identification of the YY1 binding site at the 5' enhancer region.
Chan PK, Chan FY, Morris SW, Xie Z
Nucleic Acids Res. 1997
PubMed ID: 9092633
A two-dimensional gel database of human colon carcinoma proteins.
Ji H, Reid GE, Moritz RL, Eddes JS, Burgess AW, Simpson RJ
Electrophoresis. 1997
PubMed ID: 9150948
The identification of novel sequences expressed in the mouse notochord.
Sowden JC, Morrison K, Putt W, Beddington R, Edwards YH
Mamm Genome. 1997
PubMed ID: 9021147
Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5).
Fujimoto J, Shiota M, Iwahara T, Seki N, Satoh H, Mori S, Yamamoto T
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8633037
C23 interacts with B23, a putative nucleolar-localization-signal-binding protein.
Li YP, Busch RK, Valdez BC, Busch H
Eur J Biochem. 1996
PubMed ID: 8620867
Sedimentation analyses of the salt- and divalent metal ion-induced oligomerization of nucleolar protein B23.
Herrera JE, Correia JJ, Jones AE, Olson MO
Biochemistry. 1996
PubMed ID: 8611572
The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.
Redner RL, Rush EA, Faas S, Rudert WA, Corey SJ
Blood. 1996
PubMed ID: 8562957
The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.
Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW
Oncogene. 1996
PubMed ID: 8570204
The post-transcriptional regulator Rev of HIV: implications for its interaction with the nucleolar protein B23.
Miyazaki Y, Nosaka T, Hatanaka M
Biochimie. 1996
PubMed ID: 9150888
Expression of nucleophosmin/B23 in normal and neoplastic colorectal mucosa.
Nozawa Y, Van Belzen N, Van der Made AC, Dinjens WN, Bosman FT
J Pathol. 1996
PubMed ID: 8778315
Modification of nucleolar protein B23 after exposure to ionizing radiation.
Ramsamooj P, Notario V, Dritschilo A
Radiat Res. 1995
PubMed ID: 7631008
The roles of nucleolar structure and function in the subcellular location of the HIV-1 Rev protein.
Dundr M, Leno GH, Hammarskjöld ML, Rekosh D, Helga-Maria C, Olson MO
J Cell Sci. 1995
PubMed ID: 7593322
The cytotoxicity of human immunodeficiency virus type 1 Rev: implications for its interaction with the nucleolar protein B23.
Miyazaki Y, Takamatsu T, Nosaka T, Fujita S, Martin TE, Hatanaka M
Exp Cell Res. 1995
PubMed ID: 7628555
Interaction of nucleolar protein B23 with peptides related to nuclear localization signals.
Szebeni A, Herrera JE, Olson MO
Biochemistry. 1995
PubMed ID: 7794916
In vitro and ex vivo expression of nucleolar proteins B23 and p120 in benign and malignant epithelial lesions of the prostate.
Bocker T, Bittinger A, Wieland W, Buettner R, Fauser G, Hofstaedter F, Rüschoff J
Mod Pathol. 1995
PubMed ID: 7542384
Construction of a human full-length cDNA bank.
Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T
Gene. 1994
PubMed ID: 7821789
Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23.
Valdez BC, Perlaky L, Henning D, Saijo Y, Chan PK, Busch H
J Biol Chem. 1994
PubMed ID: 8089149
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, Look AT
Science. 1994
PubMed ID: 8122112
Relief of YY1-induced transcriptional repression by protein-protein interaction with the nucleolar phosphoprotein B23.
Inouye CJ, Seto E
J Biol Chem. 1994
PubMed ID: 8120001
Spatial association of HIV-1 tat protein and the nucleolar transport protein B23 in stably transfected Jurkat T-cells.
Marasco WA, Szilvay AM, Kalland KH, Helland DG, Reyes HM, Walter RJ
Arch Virol. 1994
PubMed ID: 7826206
Cytotoxic activity of rev protein of human immunodeficiency virus type 1 by nucleolar dysfunction.
Nosaka T, Takamatsu T, Miyazaki Y, Sano K, Sato A, Kubota S, Sakurai M, Ariumi Y, Nakai M, Fujita S
Exp Cell Res. 1993
PubMed ID: 8224012
Nucleolar targeting signal of Rex protein of human T-cell leukemia virus type I specifically binds to nucleolar shuttle protein B-23.
Adachi Y, Copeland TD, Hatanaka M, Oroszlan S
J Biol Chem. 1993
PubMed ID: 8314759
Characterization of seven processed pseudogenes of nucleophosmin/B23 in the human genome.
Liu QR, Chan PK
DNA Cell Biol. 1993
PubMed ID: 8471164
The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice.
Van den Eynde B, Lethé B, Van Pel A, De Plaen E, Boon T
J Exp Med. 1991
PubMed ID: 1903428
Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element.
Fankhauser C, Izaurralde E, Adachi Y, Wingfield P, Laemmli UK
Mol Cell Biol. 1991
PubMed ID: 2017166
Nucleolar distribution of proteins B23 and nucleolin in mouse preimplantation embryos as visualized by immunoelectron microscopy.
Biggiogera M, Bürki K, Kaufmann SH, Shaper JH, Gas N, Amalric F, Fakan S
Development. 1990
PubMed ID: 2100262
Structure of the gene for rat nucleolar protein B23.
Chang JH, Olson MO
J Biol Chem. 1990
PubMed ID: 2211699
Functional domains of the HIV-1 rev gene required for trans-regulation and subcellular localization.
Venkatesh LK, Mohammed S, Chinnadurai G
Virology. 1990
PubMed ID: 2109912
Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function.
Cochrane AW, Perkins A, Rosen CA
J Virol. 1990
PubMed ID: 2404140
Nucleotide sequence of a cDNA clone representing a third allele of human protein B23.
Hale TK, Mansfield BC
Nucleic Acids Res. 1989
PubMed ID: 2602120
Isolation and characterization of a molecular cDNA clone of a human mRNA from interferon-treated cells encoding nucleolar protein B23, numatrin.
Zhang XX, Thomis DC, Samuel CE
Biochem Biophys Res Commun. 1989
PubMed ID: 2478125
The nucleotide sequence of a human cDNA encoding the highly conserved nucleolar phosphoprotein B23.
Li XZ, McNeilage LJ, Whittingham S
Biochem Biophys Res Commun. 1989
PubMed ID: 2775293
A single gene codes for two forms of rat nucleolar protein B23 mRNA.
Chang JH, Olson MO
J Biol Chem. 1989
PubMed ID: 2745414
Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth.
Chan WY, Liu QR, Borjigin J, Busch H, Rennert OM, Tease LA, Chan PK
Biochemistry. 1989
PubMed ID: 2713355
cDNA and deduced primary structure of rat protein B23, a nucleolar protein containing highly conserved sequences.
Chang JH, Dumbar TS, Olson MO
J Biol Chem. 1988
PubMed ID: 3417636
DNA cloning and amino acid sequence determination of a major constituent protein of mammalian nucleoli. Correspondence of the nucleoplasmin-related protein NO38 to mammalian protein B23.
Schmidt-Zachmann MS, Franke WW
Chromosoma. 1988
PubMed ID: 3219912
Amino acid sequence of a specific antigenic peptide of protein B23.
Chan PK, Chan WY, Yung BY, Cook RG, Aldrich MB, Ku D, Goldknopf IL, Busch H
J Biol Chem. 1986
PubMed ID: 2429957
Amino acid sequence of protein B23 phosphorylation site.
Chan PK, Aldrich M, Cook RG, Busch H
J Biol Chem. 1986
PubMed ID: 3944116

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	4869	18148	25498
EnsEMBL Gene(s)	ENSG00000181163	ENSMUSG00000057113	ENSRNOG00000004616
Unigene	Hs.557550	Mm.485384	Rn.54537
Homologene	NPM1	Npm1	Npm1
OMIM	164040	N/A	N/A
GeneCards	NPM1	N/A	N/A
Beta Cell Genomics	DT.100045872 DT.100045881 DT.100740910 DT.100740946 DT.100740960 DT.100740963 DT.100740969 DT.100809844 DT.100913558 DT.120889937 DT.120890065 DT.120890240 DT.120890251 DT.87018247 DT.91674473 DT.91783568 DT.91783601 DT.95370553 DT.95370562 DT.95370767 DT.95370807 DT.99984058	DT.101200099 DT.102553416 DT.103581379 DT.55128410 DT.91372346 DT.94144570 DT.94214582 DT.94214609 DT.94214628	N/A
Reactome	P06748	N/A	N/A
Plasma Peptide Atlas	ENSP00000296930	N/A	N/A
WikiGenes	4869	18148	25498

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
NPM1	HDAC5	BioGRID	empirical	21081666
NPM1	CHAF1A	IntAct	empirical	19410544
NPM1	CDK2	HPRD, BioGRID	empirical	11278991 16376875
NPM1	CDKN1A	BioGRID	empirical	19221506
NPM1	CDKN2A	MINT, IntAct, BioGRID	empirical	16957780 15989956 16679321 17277230
NPM1	NPM3	MINT	empirical	15596447
NPM1	NOP56	BioGRID	empirical	12777385
NPM1	CENPA	IntAct, BioGRID	empirical	19410544 19410545
NPM1	CENPF	BioGRID	empirical	14968112
NPM1	CTCF	BioGRID	empirical	14759373
NPM1	TCERG1	HPRD, BioGRID	empirical	15456888
NPM1	YWHAQ	BioGRID	empirical	20618440 15161933
NPM1	GABARAP	IntAct	empirical	20562859
NPM1	GABARAPL2	IntAct	empirical	20562859
NPM1	LIN54	IntAct	empirical	17531812
NPM1	SREK1	HPRD, BioGRID	empirical	14559993
NPM1	PARP1	HPRD, BioGRID	empirical	9642267 15607978
NPM1	CSNK2A1	IntAct	empirical	22113938
NPM1	GADD45A	HPRD	empirical	15644315
NPM1	EP300	BioGRID	empirical	16107701
NPM1	AKT1	BioGRID	empirical	18931307
NPM1	ESR1	IntAct, BioGRID	empirical	21182205 20308691
NPM1	FANCC	BioGRID	empirical	20864535
NPM1	MED19	IntAct	empirical	15175163
NPM1	HABP4	MINT	empirical	19523114
NPM1	NCOA6	IntAct	empirical	10866662
NPM1	SWAP70	BioGRID	empirical	9642267
NPM1	RRP1B	BioGRID	empirical	19710015
NPM1	RPGRIP1L	IntAct	empirical	21565611
NPM1	SIRT1	BioGRID	empirical	20431927
NPM1	PADI4	BioGRID	empirical	19843866
NPM1	GABARAPL1	IntAct	empirical	20562859
NPM1	ALK	HPRD	empirical	11888936
NPM1	SENP3	HPRD, MINT	empirical	18259216
NPM1	GH1	IntAct	empirical	17353931
NPM1	GNAI2	IntAct	empirical	21988832
NPM1	GRB2	HPRD, IntAct, MIPS, BioGRID	empirical	8633037 12577067 14968112
NPM1	GRB7	BioGRID	empirical	14968112
NPM1	HIST1H1C	BioGRID	empirical	20431927
NPM1	H2AFX	BioGRID	empirical	16522924
NPM1	HIST1H1A	BioGRID	empirical	20431927
NPM1	HDAC1	MINT, BioGRID	empirical	17318229
NPM1	HDAC2	MINT, BioGRID	empirical	17318229
NPM1	ACACA	BioGRID	empirical	20431927
NPM1	HLA-B	IntAct	empirical	17353931
NPM1	HMGA1	BioGRID	empirical	16293633
NPM1	HNRNPU	BioGRID	empirical	20431927
NPM1	HOXA7	IntAct	empirical	21988832
NPM1	PRMT2	IntAct	empirical	12039952
NPM1	EIF3E	IntAct	empirical	21988832
NPM1	IRS1	HPRD, MIPS	empirical	8633037
NPM1	ARF1	HPRD	empirical	14636574 15684379
NPM1	ARRB1	IntAct	empirical	17620599
NPM1	ARRB2	IntAct	empirical	17620599
NPM1	MCC	IntAct	empirical	17353931
NPM1	MDM2	HPRD, IntAct	empirical	15144954
NPM1	AFF1	BioGRID	empirical	21030982
NPM1	ABCC1	IntAct	empirical	21988832
NPM1	HNRNPM	BioGRID	empirical	20431927
NPM1	NCL	HPRD, BioGRID	empirical	10503877 8620867 20431927
NPM1	NOP2	HPRD	empirical	8089149
NPM1	YBX1	MINT, BioGRID	empirical	15596447 20431927
NPM1	NUMA1	BioGRID	empirical	14968112
NPM1	NUP98	BioGRID	empirical	14968112
NPM1	PA2G4	IntAct	empirical	15064750
NPM1	PC	BioGRID	empirical	20431927
NPM1	PIK3R1	BioGRID	empirical	14968112
NPM1	PLCG2	HPRD, MIPS	empirical	9819383
NPM1	PLK1	HPRD	empirical	15190079
NPM1	PML	BioGRID	empirical	18212063
NPM1	PPID	BioGRID	empirical	14968112
NPM1	NSUN2	BioGRID	empirical	17215513
NPM1	PINX1	IntAct	empirical	17353931
NPM1	MED9	IntAct	empirical	15175163
NPM1	MED29	IntAct	empirical	15175163
NPM1	OTUB1	BioGRID	empirical	18954305
NPM1	LYAR	IntAct, BioGRID	empirical	17353931
NPM1	EIF2AK2	HPRD, MINT	empirical	12882984 16957780
NPM1	CTNNBL1	BioGRID	empirical	21385873
NPM1	PSMC4	IntAct	empirical	21988832
NPM1	PTBP1	MINT	empirical	16376875
NPM1	CBX8	IntAct	empirical	21282530
NPM1	CASKIN1	BioGRID	empirical	14968112
NPM1	USP36	BioGRID	empirical	19679658
NPM1	BARD1	BioGRID	empirical	15184379
NPM1	RARA	BioGRID	empirical	18212063
NPM1	RELA	MINT, IntAct	empirical	14743216 21988832
NPM1	ACTB	IntAct	empirical	15047060
NPM1	RPGR	HPRD	empirical	15772089
NPM1	RPS27	MINT	empirical	15596447
NPM1	RYK	BioGRID	empirical	21875946
NPM1	SRSF1	MINT	empirical	16376875
NPM1	SHC1	HPRD, MIPS	empirical	8633037
NPM1	SMARCA4	BioGRID	empirical	20460684
NPM1	SUMO2	MINT	empirical	18259216
NPM1	BRCA1	BioGRID	empirical	15184379
NPM1	TFAP2A	HPRD, MINT, BioGRID	empirical	17318229
NPM1	TOP1	IntAct, BioGRID	empirical	15848144
NPM1	TP53	HPRD, MINT, IntAct, BioGRID	empirical	12080348 16376884 15144954 16740634 17277230
NPM1	TRAF6	IntAct	empirical	17353931
NPM1	UBC	MINT, BioGRID	empirical	18259216 18319061 15665273 15184379 16196087 22178446 21987572 21139048 21890473 21906983
NPM1	UQCRH	IntAct	empirical	21988832
NPM1	USF2	IntAct, BioGRID	empirical	17353931
NPM1	XPO1	HPRD	empirical	16041368
NPM1	YY1	BioGRID	empirical	16170350
NPM1	YWHAZ	MINT	empirical	15161933
NPM1	CNBP	IntAct	empirical	17353931
NPM1	GPANK1	MINT	empirical	15596447
NPM1	ZNF668	BioGRID	empirical	21852383
NPM1	CDK5RAP3	BioGRID	empirical	20164180
NPM1	HMGA2	BioGRID	empirical	16293633
NPM1	CDT1	BioGRID	empirical	18162579
NPM1	MAP1LC3B	IntAct	empirical	20562859
NPM1	HIST3H3	HPRD, BioGRID	empirical	11602260
NPM1	HIST2H2AC	BioGRID	empirical	16107701
NPM1	HIST2H2BE	BioGRID	empirical	16107701
NPM1	HIST1H3A	BioGRID	empirical	16107701
NPM1	HIST1H4A	BioGRID	empirical	16107701
NPM1	MED10	IntAct	empirical	15175163
NPM1	DOT1L	BioGRID	empirical	20431927
NPM1	DYRK2	BioGRID	empirical	19287380
NPM1	MAP1LC3A	IntAct	empirical	20562859
NPM1	CBX2	IntAct	empirical	21282530
NPM1	CSDA	BioGRID	empirical	20431927
NPM1	CDC14A	BioGRID	empirical	14968112
NPM1	H1FX	BioGRID	empirical	20431927
NPM1	MAP3K14	MINT, IntAct	empirical	14743216
NPM1	DDX21	BioGRID	empirical	20431927
NPM1	CD4	BioGRID	empirical	15047060
NPM1	HAND2	HPRD, BioGRID	empirical	11812799
NPM1	ACY1	IntAct	empirical	21988832
NPM1	IKBKE	IntAct	empirical	17353931
NPM1	KIAA0101	BioGRID	empirical	21628590
NPM1	CDK1	HPRD	empirical	12058066 11278991