ATM

Summary Top Help

Gene Description:

ataxia telangiectasia mutated homolog (human); ataxia telangiectasia mutated

Synonyms:

ATD, ATE, C030026E19Rik, TELO1, ATM, ATA, TEL1, ATDC, Atm, AI256621, AT1, ATC

Orthologs:

Human ATM (protein-coding), Mouse Atm (protein-coding), Rat Atm (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd2	Mouse	chr9:32308040..98698811	66.39	764	6 no lod score

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:108093211..108239829 (146.62 kb) View in Genome Browser

(Mouse) NCBIM37 - chr9:53245227..53344845 (99.62 kb) View in Genome Browser

(Rat) RGSC3.4 - chr8:56894746..56996565 (101.82 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for ATM:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for ATM:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 3

Biocarta: 10

Reactome: 20

NCI-Nature Pathway Interaction Database: 9

Gene Ontology: 51

Cell cycle checkpoint	GO:0000075
Nucleotide binding	GO:0000166
Double-strand break repair via homologous recombination	GO:0000724
Chromosome, telomeric region	GO:0000781
Response to hypoxia	GO:0001666
Somitogenesis	GO:0001756
Pre-B cell allelic exclusion	GO:0002331
DNA binding	GO:0003677
Protein serine/threonine kinase activity	GO:0004674
DNA-dependent protein kinase activity	GO:0004677
Protein binding	GO:0005515
ATP binding	GO:0005524
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Cytoplasm	GO:0005737
Spindle	GO:0005819
DNA repair	GO:0006281
Double-strand break repair	GO:0006302
Response to DNA damage stimulus	GO:0006974
DNA damage induced protein phosphorylation	GO:0006975
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977
Cell cycle arrest	GO:0007050
Mitotic cell cycle spindle assembly checkpoint	GO:0007094
Reciprocal meiotic recombination	GO:0007131
Signal transduction	GO:0007165
Female gamete generation	GO:0007292
Brain development	GO:0007420
Heart development	GO:0007507
Cell death	GO:0008219
DNA damage response, signal transduction resulting in induction of apoptosis	GO:0008630
Response to ionizing radiation	GO:0010212
Cytoplasmic membrane-bounded vesicle	GO:0016023
1-phosphatidylinositol-3-kinase activity	GO:0016303
Peptidyl-serine phosphorylation	GO:0018105
Negative regulation of B cell proliferation	GO:0030889
G2/M transition DNA damage checkpoint	GO:0031572
Protein complex binding	GO:0032403
Histone serine kinase activity	GO:0035174
Phosphatidylinositol-3-phosphate biosynthetic process	GO:0036092
Lipoprotein catabolic process	GO:0042159
Positive regulation of apoptotic process	GO:0043065
Negative regulation of apoptotic process	GO:0043066
Positive regulation of DNA damage response, signal transduction by p53 class mediator	GO:0043517
Positive regulation of neuron apoptosis	GO:0043525
Protein autophosphorylation	GO:0046777
Protein dimerization activity	GO:0046983
Protein N-terminus binding	GO:0047485
Regulation of cell cycle	GO:0051726
Histone mRNA catabolic process	GO:0071044
Cellular response to gamma radiation	GO:0071480
Replicative senescence	GO:0090399

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 1039

Tcl1 interacts with Atm and enhances NF-κB activation in hematologic malignancies.
Gaudio E, Spizzo R, Paduano F, Luo Z, Efanov A, Palamarchuk A, Leber AS, Kaou M, Zanesi N, Bottoni A, Costinean S, Rassenti LZ, Nakamura T, Kipps TJ, Aqeilan RI, Pekarsky Y, Trapasso F, Croce CM
Blood. 2012
PubMed ID: 22065599
ATM-mediated DNA damage signals mediate immune escape through integrin-αvβ3-dependent mechanisms.
Jinushi M, Chiba S, Baghdadi M, Kinoshita I, Dosaka-Akita H, Ito K, Yoshiyama H, Yagita H, Uede T, Takaoka A
Cancer Res. 2012
PubMed ID: 22094875
Association between Ataxia Telangiectasia Mutated gene polymorphisms and childhood leukemia in Taiwan.
Wang CH, Wu KH, Yang YL, Peng CT, Tsai FJ, Lin DT, Chiu CF, Lin CC, Bau DT
Chin J Physiol. 2011
PubMed ID: 22229509
Mode of ATM-dependent suppression of chromosome translocation.
Yamauchi M, Suzuki K, Oka Y, Suzuki M, Kondo H, Yamashita S
Biochem Biophys Res Commun. 2011
PubMed ID: 22093823
Alterations of ATM and CADM1 in chromosomal 11q22.3-23.2 region are associated with the development of invasive cervical carcinoma.
Mazumder Indra D, Mitra S, Roy A, Mondal RK, Basu PS, Roychoudhury S, Chakravarty R, Panda CK
Hum Genet. 2011
PubMed ID: 21643982
Telomere protection by TPP1/POT1 requires tethering to TIN2.
Takai KK, Kibe T, Donigian JR, Frescas D, de Lange T
Mol Cell. 2011
PubMed ID: 22099311
ATM controls meiotic double-strand-break formation.
Lange J, Pan J, Cole F, Thelen MP, Jasin M, Keeney S
Nature. 2011
PubMed ID: 22002603
An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.
Ramachandran S, Tran DD, Klebba-Faerber S, Kardinal C, Whetton AD, Tamura T
RNA. 2011
PubMed ID: 21937706
Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways.
Keimling M, Volcic M, Csernok A, Wieland B, Dörk T, Wiesmüller L
FASEB J. 2011
PubMed ID: 21778326
Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase.
Nam EA, Zhao R, Cortez D
J Biol Chem. 2011
PubMed ID: 21908846
Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional.
Lossaint G, Besnard E, Fisher D, Piette J, Dulić V
Oncogene. 2011
PubMed ID: 21532626
Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts.
Mahalingam D, Tay LL, Tan WH, Chai JH, Wang X
FEBS J. 2011
PubMed ID: 21824286
Analysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2/M checkpoint arrest.
Brunton H, Goodarzi AA, Noon AT, Shrikhande A, Hansen RS, Jeggo PA, Shibata A
Mol Cell Biol. 2011
PubMed ID: 21791604
ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.
Gatei M, Jakob B, Chen P, Kijas AW, Becherel OJ, Gueven N, Birrell G, Lee JH, Paull TT, Lerenthal Y, Fazry S, Taucher-Scholz G, Kalb R, Schindler D, Waltes R, Dörk T, Lavin MF
J Biol Chem. 2011
PubMed ID: 21757780
Characterisation of ATM mutations in Slavic Ataxia telangiectasia patients.
Soukupova J, Pohlreich P, Seemanova E
Neuromolecular Med. 2011
PubMed ID: 21833744
A role for vascular deficiency in retinal pathology in a mouse model of ataxia-telangiectasia.
Raz-Prag D, Galron R, Segev-Amzaleg N, Solomon AS, Shiloh Y, Barzilai A, Frenkel D
Am J Pathol. 2011
PubMed ID: 21763675
TRAIL and guardian angel of genome integrity: ATM boards TRAIL blazer.
Farooqi AA, Waseem S, Ashraf MS, Iqbal MJ, Bhatti S
J Cancer Res Clin Oncol. 2011
PubMed ID: 21706325
Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair.
Woodbine L, Brunton H, Goodarzi AA, Shibata A, Jeggo PA
Nucleic Acids Res. 2011
PubMed ID: 21596788
DNA damage-sensing kinases mediate the mouse 2-cell embryo's response to genotoxic stress.
Mu XF, Jin XL, Farnham MM, Li Y, O'Neill C
Biol Reprod. 2011
PubMed ID: 21593482
ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A.
Shouse GP, Nobumori Y, Panowicz MJ, Liu X
Oncogene. 2011
PubMed ID: 21460856
ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability.
Goetz EM, Shankar B, Zou Y, Morales JC, Luo X, Araki S, Bachoo R, Mayo LD, Boothman DA
Oncogene. 2011
PubMed ID: 21460853
Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein.
Otterbein LE, Hedblom A, Harris C, Csizmadia E, Gallo D, Wegiel B
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21849621
Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase.
Kawasumi M, Lemos B, Bradner JE, Thibodeau R, Kim YS, Schmidt M, Higgins E, Koo SW, Angle-Zahn A, Chen A, Levine D, Nguyen L, Heffernan TP, Longo I, Mandinova A, Lu YP, Conney AH, Nghiem P
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21844338
ATM protects against oxidative stress induced by oxidized low-density lipoprotein.
Semlitsch M, Shackelford RE, Zirkl S, Sattler W, Malle E
DNA Repair (Amst). 2011
PubMed ID: 21669554
Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours.
Reiman A, Srinivasan V, Barone G, Last JI, Wootton LL, Davies EG, Verhagen MM, Willemsen MA, Weemaes CM, Byrd PJ, Izatt L, Easton DF, Thompson DJ, Taylor AM
Br J Cancer. 2011
PubMed ID: 21792198
Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotype.
Micol R, Ben Slama L, Suarez F, Le Mignot L, Beauté J, Mahlaoui N, Dubois d'Enghien C, Laugé A, Hall J, Couturier J, Vallée L, Delobel B, Rivier F, Nguyen K, Billette de Villemeur T, Stephan JL, Bordigoni P, Bertrand Y, Aladjidi N, Pedespan JM, Thomas C, Pellier I, Koenig M, Hermine O, Picard C, Moshous D, Neven B, Lanternier F, Blanche S, Tardieu M, Debré M, Fischer A, Stoppa-Lyonnet D, CEREDIH Network Investigators
J Allergy Clin Immunol. 2011
PubMed ID: 21665257
DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin.
Jakob B, Splinter J, Conrad S, Voss KO, Zink D, Durante M, Löbrich M, Taucher-Scholz G
Nucleic Acids Res. 2011
PubMed ID: 21511815
The mef/elf4 transcription factor fine tunes the DNA damage response.
Sashida G, Bae N, Di Giandomenico S, Asai T, Gurvich N, Bazzoli E, Liu Y, Huang G, Zhao X, Menendez S, Nimer SD
Cancer Res. 2011
PubMed ID: 21616937
ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair.
Segal-Raz H, Mass G, Baranes-Bachar K, Lerenthal Y, Wang SY, Chung YM, Ziv-Lehrman S, Ström CE, Helleday T, Hu MC, Chen DJ, Shiloh Y
EMBO Rep. 2011
PubMed ID: 21637298
A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage.
Yang Y, Xia F, Hermance N, Mabb A, Simonson S, Morrissey S, Gandhi P, Munson M, Miyamoto S, Kelliher MA
Mol Cell Biol. 2011
PubMed ID: 21606198
Germline ATM mutational analysis in BRCA1/BRCA2 negative hereditary breast cancer families by MALDI-TOF mass spectrometry.
Graña B, Fachal L, Darder E, Balmaña J, Ramón Y Cajal T, Blanco I, Torres A, Lázaro C, Diez O, Alonso C, Santamariña M, Velasco A, Teulé A, Lasa A, Blanco A, Izquierdo A, Borràs J, Gutiérrez-Enríquez S, Vega A, Brunet J
Breast Cancer Res Treat. 2011
PubMed ID: 21445571
Ataxia telangiectasia mutated kinase plays a protective role in β-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling.
Foster CR, Singh M, Subramanian V, Singh K
Mol Cell Biochem. 2011
PubMed ID: 21404020
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1).
Lindsey-Boltz LA, Sancar A
J Biol Chem. 2011
PubMed ID: 21502314
The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.
Kemp MG, Lindsey-Boltz LA, Sancar A
J Biol Chem. 2011
PubMed ID: 21487018
Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis.
Holloway JK, Mohan S, Balmus G, Sun X, Modzelewski A, Borst PL, Freire R, Weiss RS, Cohen PE
PLoS Genet. 2011
PubMed ID: 21655083
Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling.
D'Souza AD, Parish IA, McKay SE, Kaech SM, Shadel GS
Am J Pathol. 2011
PubMed ID: 21641396
Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.
Ugalde AP, Ramsay AJ, de la Rosa J, Varela I, Mariño G, Cadiñanos J, Lu J, Freije JM, López-Otín C
EMBO J. 2011
PubMed ID: 21522133
ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance.
Millour J, de Olano N, Horimoto Y, Monteiro LJ, Langer JK, Aligue R, Hajji N, Lam EW
Mol Cancer Ther. 2011
PubMed ID: 21518729
DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas.
Gao Y, Hayes RB, Huang WY, Caporaso NE, Burdette L, Yeager M, Chanock SJ, Berndt SI
Carcinogenesis. 2011
PubMed ID: 21504893
Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip.
Machold R, Klein C, Fishell G
Gene Expr Patterns. 2011
PubMed ID: 21440680
Stable brain ATM message and residual kinase-active ATM protein in ataxia-telangiectasia.
Li J, Chen J, Vinters HV, Gatti RA, Herrup K
J Neurosci. 2011
PubMed ID: 21593342
ATMIN is required for maintenance of genomic stability and suppression of B cell lymphoma.
Loizou JI, Sancho R, Kanu N, Bolland DJ, Yang F, Rada C, Corcoran AE, Behrens A
Cancer Cell. 2011
PubMed ID: 21575860
Integrated analysis of ATM mediated gene and protein expression impacting cellular metabolism.
Cheema AK, Timofeeva O, Varghese R, Dimtchev A, Shiekh K, Shulaev V, Suy S, Collins S, Ressom H, Jung M, Dritschilo A
J Proteome Res. 2011
PubMed ID: 21322649
Protein-protein interactions occur between p53 phosphoforms and ATM and 53BP1 at sites of exogenous DNA damage.
Al Rashid ST, Harding SM, Law C, Coackley C, Bristow RG
Radiat Res. 2011
PubMed ID: 21361779
Lower ataxia telangiectasia mutated (ATM) mRNA expression is correlated with poor outcome of laryngeal and pharyngeal cancer patients.
Lee KW, Tsai YS, Chiang FY, Huang JL, Ho KY, Yang YH, Kuo WR, Chen MK, Lin CS
Ann Oncol. 2011
PubMed ID: 21127011
EDD inhibits ATM-mediated phosphorylation of p53.
Ling S, Lin WC
J Biol Chem. 2011
PubMed ID: 21383020
Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum.
Dar I, Yosha G, Elfassy R, Galron R, Wang ZQ, Shiloh Y, Barzilai A
J Biol Chem. 2011
PubMed ID: 21300797
Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism.
Nitta E, Yamashita M, Hosokawa K, Xian M, Takubo K, Arai F, Nakada S, Suda T
Blood. 2011
PubMed ID: 21297001
Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells.
Kinoshita T, Nagamatsu G, Kosaka T, Takubo K, Hotta A, Ellis J, Suda T
Biochem Biophys Res Commun. 2011
PubMed ID: 21385566
Iron loading and oxidative stress in the Atm-/- mouse liver.
McDonald CJ, Ostini L, Wallace DF, John AN, Watters DJ, Subramaniam VN
Am J Physiol Gastrointest Liver Physiol. 2011
PubMed ID: 21292994
Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells.
Wang SC, Wu CC, Wei YY, Hong JH, Chiang CS
Int J Radiat Biol. 2011
PubMed ID: 21204616
Transforming growth factor-β regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM.
Wang Y, Yu Y, Tsuyada A, Ren X, Wu X, Stubblefield K, Rankin-Gee EK, Wang SE
Oncogene. 2011
PubMed ID: 21102523
Autophosphorylation and ATM activation: additional sites add to the complexity.
Kozlov SV, Graham ME, Jakob B, Tobias F, Kijas AW, Tanuji M, Chen P, Robinson PJ, Taucher-Scholz G, Suzuki K, So S, Chen D, Lavin MF
J Biol Chem. 2011
PubMed ID: 21149446
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks.
Moyal L, Lerenthal Y, Gana-Weisz M, Mass G, So S, Wang SY, Eppink B, Chung YM, Shalev G, Shema E, Shkedy D, Smorodinsky NI, van Vliet N, Kuster B, Mann M, Ciechanover A, Dahm-Daphi J, Kanaar R, Hu MC, Chen DJ, Oren M, Shiloh Y
Mol Cell. 2011
PubMed ID: 21362549
Human T-lymphotropic virus type 1 p30 interacts with REGgamma and modulates ATM (ataxia telangiectasia mutated) to promote cell survival.
Anupam R, Datta A, Kesic M, Green-Church K, Shkriabai N, Kvaratskhelia M, Lairmore MD
J Biol Chem. 2011
PubMed ID: 21216954
The RAG2 C terminus suppresses genomic instability and lymphomagenesis.
Deriano L, Chaumeil J, Coussens M, Multani A, Chou Y, Alekseyenko AV, Chang S, Skok JA, Roth DB
Nature. 2011
PubMed ID: 21368836
Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia.
Tomic J, Lichty B, Spaner DE
Blood. 2011
PubMed ID: 21205928
Expression of cyclin D2, P53, Rb and ATM cell cycle genes in brain tumors.
Kheirollahi M, Mehr-Azin M, Kamalian N, Mehdipour P
Med Oncol. 2011
PubMed ID: 20077038
Ataxia telangiectasia mutated influences cytochrome c oxidase activity.
Patel AY, McDonald TM, Spears LD, Ching JK, Fisher JS
Biochem Biophys Res Commun. 2011
PubMed ID: 21266166
ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes.
Mazan-Mamczarz K, Hagner PR, Zhang Y, Dai B, Lehrmann E, Becker KG, Keene JD, Gorospe M, Liu Z, Gartenhaus RB
Blood. 2011
PubMed ID: 21209379
The ATM kinase induces microRNA biogenesis in the DNA damage response.
Zhang X, Wan G, Berger FG, He X, Lu X
Mol Cell. 2011
PubMed ID: 21329876
A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis.
Jacobs C, Huang Y, Masud T, Lu W, Westfield G, Giblin W, Sekiguchi JM
Hum Mol Genet. 2011
PubMed ID: 21147755
Role of DeltaNp63gamma in epithelial to mesenchymal transition.
Lindsay J, McDade SS, Pickard A, McCloskey KD, McCance DJ
J Biol Chem. 2011
PubMed ID: 21127042
ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair.
Cosentino C, Grieco D, Costanzo V
EMBO J. 2011
PubMed ID: 21157431
ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks.
Khalil A, Morgan RN, Adams BR, Golding SE, Dever SM, Rosenberg E, Povirk LF, Valerie K
Cell Cycle. 2011
PubMed ID: 21263216
Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.
Gapud EJ, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald GK, Omi KQ, Walker LM, Bednarski JJ, McKinnon PJ, Bassing CH, Nussenzweig A, Sleckman BP
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21245316
Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.
Zha S, Jiang W, Fujiwara Y, Patel H, Goff PH, Brush JW, Dubois RL, Alt FW
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21245310
ATM-dependent cellular response to DNA double strand breaks plays a pivotal role in the maintenance of the integrity of the genome.
Suzuki K, Yamauchi M, Yamashita S
Radiat Prot Dosimetry. 2011
PubMed ID: 21224259
Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.
Campbell GR, Baudhuin A, Vranizan K, Ngai J
Mol Cell Neurosci. 2011
PubMed ID: 21194568
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group, Wellcome Trust Case Control Consortium 2, Zhou K, Bellenguez C, Spencer CC, Bennett AJ, Coleman RL, Tavendale R, Hawley SA, Donnelly LA, Schofield C, Groves CJ, Burch L, Carr F, Strange A, Freeman C, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Deloukas P, Dronov S, Duncanson A, Edkins S, Gray E, Hunt S, Jankowski J, Langford C, Markus HS, Mathew CG, Plomin R, Rautanen A, Sawcer SJ, Samani NJ, Trembath R, Viswanathan AC, Wood NW, MAGIC investigators, Harries LW, Hattersley AT, Doney AS, Colhoun H, Morris AD, Sutherland C, Hardie DG, Peltonen L, McCarthy MI, Holman RR, Palmer CN, Donnelly P, Pearson ER
Nat Genet. 2011
PubMed ID: 21186350
The synergistic cytotoxicity of clofarabine, fludarabine and busulfan in AML cells involves ATM pathway activation and chromatin remodeling.
Valdez BC, Li Y, Murray D, Champlin RE, Andersson BS
Biochem Pharmacol. 2011
PubMed ID: 20933509
ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks.
Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW
Nature. 2011
PubMed ID: 21160472
ATM-mediated NuSAP phosphorylation induces mitotic arrest.
Xie P, Li L, Xing G, Tian C, Yin Y, He F, Zhang L
Biochem Biophys Res Commun. 2011
PubMed ID: 21130744
Analysis of D1853N ATM polymorphism in radiosensitive patients with cervical carcinoma.
Beránek M, Drastíková M, Paulíková S, Sirák I, Vosmik M, Petera J
Acta Medica (Hradec Kralove). 2011
PubMed ID: 22250480
miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase.
Song L, Lin C, Wu Z, Gong H, Zeng Y, Wu J, Li M, Li J
PLoS One. 2011
PubMed ID: 21980462
Interaction of hnRNPA1/A2 and DAZAP1 with an Alu-derived intronic splicing enhancer regulates ATM aberrant splicing.
Pastor T, Pagani F
PLoS One. 2011
PubMed ID: 21858080
Cutaneous squamous cell carcinoma (SCC) and the DNA damage response: pATM expression patterns in pre-malignant and malignant keratinocyte skin lesions.
Ismail F, Ikram M, Purdie K, Harwood C, Leigh I, Storey A
PLoS One. 2011
PubMed ID: 21747934
IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway.
Duan X, Ponomareva L, Veeranki S, Choubey D
PLoS One. 2011
PubMed ID: 21573174
p38 MAPK-Mediated Bmi-1 down-regulation and defective proliferation in ATM-deficient neural stem cells can be restored by Akt activation.
Kim J, Hwangbo J, Wong PK
PLoS One. 2011
PubMed ID: 21305053
A novel role for ATM in regulating proteasome-mediated protein degradation through suppression of the ISG15 conjugation pathway.
Wood LM, Sankar S, Reed RE, Haas AL, Liu LF, McKinnon P, Desai SD
PLoS One. 2011
PubMed ID: 21298066
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
Signals from the nucleus: activation of NF-kappaB by cytosolic ATM in the DNA damage response.
Hadian K, Krappmann D
Sci Signal. 2011
PubMed ID: 21245467
Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy.
Bandi S, Joseph B, Berishvili E, Singhania R, Wu YM, Cheng K, Gupta S
Am J Pathol. 2011
PubMed ID: 21224054
ATM mediated phosphorylation of CHD4 contributes to genome maintenance.
Urquhart AJ, Gatei M, Richard DJ, Khanna KK
Genome Integr. 2011
PubMed ID: 21219611
A positive role for c-Abl in Atm and Atr activation in DNA damage response.
Wang X, Zeng L, Wang J, Chau JF, Lai KP, Jia D, Poonepalli A, Hande MP, Liu H, He G, He L, Li B
Cell Death Differ. 2011
PubMed ID: 20798688
Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas.
Squatrito M, Brennan CW, Helmy K, Huse JT, Petrini JH, Holland EC
Cancer Cell. 2010
PubMed ID: 21156285
The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain.
Kanu N, Penicud K, Hristova M, Wong B, Irvine E, Plattner F, Raivich G, Behrens A
J Biol Chem. 2010
PubMed ID: 20889973
Association between ataxia telangiectasia mutated gene polymorphisms and breast cancer in Taiwanese females.
Wang HC, Chang WS, Tsai RY, Tsai CW, Liu LC, Su CH, Cheng HN, Tsou YA, Sun SS, Lin CC, Bau DT
Anticancer Res. 2010
PubMed ID: 21187516
Association between DNA repair gene ATM polymorphisms and oral cancer susceptibility.
Bau DT, Chang CH, Tsai MH, Chiu CF, Tsou YA, Wang RF, Tsai CW, Tsai RY
Laryngoscope. 2010
PubMed ID: 21108427
mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.
Cam H, Easton JB, High A, Houghton PJ
Mol Cell. 2010
PubMed ID: 21095582
Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy cantonese.
Shen GP, Pan QH, Hong MH, Qin HD, Xu YF, Chen LZ, Feng QS, Jorgensen TJ, Shugart YY, Zeng YX, Jia WH
Int J Cancer. 2010
PubMed ID: 21077165
Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J.
Ng WL, Yan D, Zhang X, Mo YY, Wang Y
DNA Repair (Amst). 2010
PubMed ID: 20869334
Genetic Variants of NPAT-ATM and AURKA are Associated with an Early Adverse Reaction in the Gastrointestinal Tract of Patients with Cervical Cancer Treated with Pelvic Radiation Therapy.
Ishikawa A, Suga T, Shoji Y, Kato S, Ohno T, Ishikawa H, Yoshinaga S, Ohara K, Ariga H, Nomura K, Shibamoto Y, Ishikawa KI, Moritake T, Michikawa Y, Iwakawa M, Imai T
Int J Radiat Oncol Biol Phys. 2010
PubMed ID: 21050672
ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks.
Bennardo N, Stark JM
PLoS Genet. 2010
PubMed ID: 21079684
Antioxidant vitamins intake, ataxia telangiectasia mutated (ATM) genetic polymorphisms, and breast cancer risk.
Lee SA, Lee KM, Lee SJ, Yoo KY, Park SK, Noh DY, Ahn SH, Kang D
Nutr Cancer. 2010
PubMed ID: 21058196
The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress.
Kim TS, Kawaguchi M, Suzuki M, Jung CG, Asai K, Shibamoto Y, Lavin MF, Khanna KK, Miura Y
Dis Model Mech. 2010
PubMed ID: 20876357
Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer.
Kim M, Kang HG, Lee SY, Lee HC, Lee EB, Choi YY, Lee WK, Cho S, Jin G, Jheon HS, Son JW, Lee MH, Jung DK, Cha SI, Kim CH, Kang YM, Kam S, Jung TH, Jheon S, Park JY
Cancer Sci. 2010
PubMed ID: 20731661
ATM activation by oxidative stress.
Guo Z, Kozlov S, Lavin MF, Person MD, Paull TT
Science. 2010
PubMed ID: 20966255
Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.
Qi Y, Schoene NW, Lartey FM, Cheng WH
J Biol Chem. 2010
PubMed ID: 20709753
DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome.
Mercer JR, Cheng KK, Figg N, Gorenne I, Mahmoudi M, Griffin J, Vidal-Puig A, Logan A, Murphy MP, Bennett M
Circ Res. 2010
PubMed ID: 20705925
ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.
Wu ZH, Wong ET, Shi Y, Niu J, Chen Z, Miyamoto S, Tergaonkar V
Mol Cell. 2010
PubMed ID: 20932476
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.
Hinz M, Stilmann M, Arslan SÇ, Khanna KK, Dittmar G, Scheidereit C
Mol Cell. 2010
PubMed ID: 20932475
The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells.
Fernandez-Diaz LC, Laurent A, Girasoli S, Turco M, Longobardi E, Iotti G, Jenkins NA, Fiorenza MT, Copeland NG, Blasi F
Development. 2010
PubMed ID: 20826531
A functional single nucleotide polymorphism in promoter of ATM is associated with longevity.
Chen T, Dong B, Lu Z, Tian B, Zhang J, Zhou J, Wu H, Zhang Y, Wu J, Lin P, Zhang J, Xu H, Mo X
Mech Ageing Dev. 2010
PubMed ID: 20816691
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.
Liu Y, Shete S, Wang LE, El-Zein R, Etzel CJ, Liang FW, Armstrong G, Tsavachidis S, Gilbert MR, Aldape KD, Xing J, Wu X, Wei Q, Bondy ML
Carcinogenesis. 2010
PubMed ID: 20610542
A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage.
Carlessi L, Buscemi G, Fontanella E, Delia D
Biochim Biophys Acta. 2010
PubMed ID: 20599567
AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling.
Sherman MH, Kuraishy AI, Deshpande C, Hong JS, Cacalano NA, Gatti RA, Manis JP, Damore MA, Pellegrini M, Teitell MA
Mol Cell. 2010
PubMed ID: 20864035
ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress.
Wang S, Tian C, Xing G, Gao M, Jiao W, Xiao T, Yin Y, He F, Zhang L
FEBS Lett. 2010
PubMed ID: 20713054
Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence.
Zhan H, Suzuki T, Aizawa K, Miyagawa K, Nagai R
J Biol Chem. 2010
PubMed ID: 20639198
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.
Takai H, Xie Y, de Lange T, Pavletich NP
Genes Dev. 2010
PubMed ID: 20801936
Missense variants in ATM in 26,101 breast cancer cases and 29,842 controls.
Fletcher O, Johnson N, dos Santos Silva I, Orr N, Ashworth A, Nevanlinna H, Heikkinen T, Aittomäki K, Blomqvist C, Burwinkel B, Bartram CR, Meindl A, Schmutzler RK, Cox A, Brock I, Elliott G, Reed MW, Southey MC, Smith L, Spurdle AB, Hopper JL, Couch FJ, Olson JE, Wang X, Fredericksen Z, Schürmann P, Waltes R, Bremer M, Dörk T, Devilee P, van Asperen CJ, Tollenaar RA, Seynaeve C, Hall P, Czene K, Humphreys K, Liu J, Ahmed S, Dunning AM, Maranian M, Pharoah PD, Chenevix-Trench G, kConFab Investigators, AOCS Group, Beesley J, Bogdanova NV, Antonenkova NN, Zalutsky IV, Anton-Culver H, Ziogas A, Brauch H, Ko YD, Hamann U, GENICA Consortium, Fasching PA, Strick R, Ekici AB, Beckmann MW, Giles GG, Severi G, Baglietto L, English DR, Milne RL, Benítez J, Arias JI, Pita G, Nordestgaard BG, Bojesen SE, Flyger H, Kang D, Yoo KY, Noh DY, Mannermaa A, Kataja V, Kosma VM, García-Closas M, Chanock S, Lissowska J, Brinton LA, Chang-Claude J, Wang-Gohrke S, Broeks A, Schmidt MK, van Leeuwen FE, Van't Veer LJ, Margolin S, Lindblom A, Humphreys MK, Morrison J, Platte R, Easton DF, Peto J, Breast Cancer Association Consortium
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20826828
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.
Hurov KE, Cotta-Ramusino C, Elledge SJ
Genes Dev. 2010
PubMed ID: 20810650
Toward a comprehensive prognostic scoring system in chronic lymphocytic leukemia based on a combination of genetic parameters.
Haferlach C, Dicker F, Weiss T, Schnittger S, Beck C, Grote-Metke A, Oruzio D, Kern W, Haferlach T
Genes Chromosomes Cancer. 2010
PubMed ID: 20552631
Association of P53 and ATM Polymorphisms with Risk of Radiation-Induced Pneumonitis in Lung Cancer Patients Treated with Radiotherapy.
Yang M, Zhang L, Bi N, Ji W, Tan W, Zhao L, Yu D, Wu C, Wang L, Lin D
Int J Radiat Oncol Biol Phys. 2010
PubMed ID: 20729006
The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis.
Li M, Fang X, Baker DJ, Guo L, Gao X, Wei Z, Han S, van Deursen JM, Zhang P
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20663956
BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery.
Facchino S, Abdouh M, Chatoo W, Bernier G
J Neurosci. 2010
PubMed ID: 20668194
Association between polymorphisms of the ataxia telangiectasia mutated gene and breast cancer risk: evidence from the current studies.
Lu PH, Wei MX, Si SP, Liu X, Shen W, Tao GQ, Chen MB
Breast Cancer Res Treat. 2010
PubMed ID: 20665102
A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.
Ho-Pun-Cheung A, Assenat E, Bascoul-Mollevi C, Bibeau F, Boissière-Michot F, Thezenas S, Cellier D, Azria D, Rouanet P, Senesse P, Ychou M, Lopez-Crapez E
Pharmacogenomics J. 2010
PubMed ID: 20644561
Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease.
Ousset M, Bouquet F, Fallone F, Biard D, Dray C, Valet P, Salles B, Muller C
Cell Cycle. 2010
PubMed ID: 20676049
ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining.
Rahal EA, Henricksen LA, Li Y, Williams RS, Tainer JA, Dixon K
Cell Cycle. 2010
PubMed ID: 20647759
Phosphorylation of p300 by ATM controls the stability of NBS1.
Jang ER, Choi JD, Jeong G, Lee JS
Biochem Biophys Res Commun. 2010
PubMed ID: 20471956
ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.
Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Murphy MM, Tepsuporn S, Gatti RA, Look AT, Alt FW
J Exp Med. 2010
PubMed ID: 20566716
Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C.
Moon DO, Kim MO, Nam TJ, Kim SK, Choi YH, Kim GY
Oncol Rep. 2010
PubMed ID: 20514472
Interaction between BRCA1/BRCA2 and ATM/ATR associate with breast cancer susceptibility in a Chinese Han population.
Wang K, Ye Y, Xu Z, Zhang X, Hou Z, Cui Y, Song Y
Cancer Genet Cytogenet. 2010
PubMed ID: 20513533
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest.
Shibata A, Barton O, Noon AT, Dahm K, Deckbar D, Goodarzi AA, Löbrich M, Jeggo PA
Mol Cell Biol. 2010
PubMed ID: 20421415
Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.
Kaizuka T, Hara T, Oshiro N, Kikkawa U, Yonezawa K, Takehana K, Iemura S, Natsume T, Mizushima N
J Biol Chem. 2010
PubMed ID: 20427287
Activator-Mediator binding regulates Mediator-cofactor interactions.
Ebmeier CC, Taatjes DJ
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20534441
Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.
Travis RC, Reeves GK, Green J, Bull D, Tipper SJ, Baker K, Beral V, Peto R, Bell J, Zelenika D, Lathrop M, Million Women Study Collaborators
Lancet. 2010
PubMed ID: 20605201
Mitotic DNA damage response: Polo-like kinase-1 is dephosphorylated through ATM-Chk1 pathway.
Lee HJ, Hwang HI, Jang YJ
Cell Cycle. 2010
PubMed ID: 20581453
ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks.
Shanbhag NM, Rafalska-Metcalf IU, Balane-Bolivar C, Janicki SM, Greenberg RA
Cell. 2010
PubMed ID: 20550933
Lack of association between ATM C.1066-6T > G mutation and breast cancer risk: a meta-analysis of 8,831 cases and 4,957 controls.
Ding H, Mao C, Li SM, Liu Q, Lin L, Chen Q
Breast Cancer Res Treat. 2010
PubMed ID: 20544271
Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.
Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J
Breast Cancer Res Treat. 2010
PubMed ID: 20496165
Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.
Orsburn B, Escudero B, Prakash M, Gesheva S, Liu G, Huso DL, Franco S
Mol Cell Biol. 2010
PubMed ID: 20231360
ATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation.
Pizarro JG, Folch J, de la Torre AV, Junyent F, Verdaguer E, Jordan J, Pallas M, Camins A
J Cell Biochem. 2010
PubMed ID: 20213763
Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.
Loizidou MA, Cariolou MA, Neuhausen SL, Newbold RF, Bashiardes E, Marcou Y, Michael T, Daniel M, Kakouri E, Papadopoulos P, Malas S, Hadjisavvas A, Kyriacou K
Breast Cancer Res Treat. 2010
PubMed ID: 19714462
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
Importance of ATM gene as a susceptible trait: predisposition role of D1853N polymorphism in breast cancer.
Mehdipour P, Mahdavi M, Mohammadi-Asl J, Atri M
Med Oncol. 2010
PubMed ID: 20396981
Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM.
Bower JJ, Zhou Y, Zhou T, Simpson DA, Arlander SJ, Paules RS, Cordeiro-Stone M, Kaufmann WK
Cell Cycle. 2010
PubMed ID: 20372057
Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study.
Bernstein JL, Haile RW, Stovall M, Boice JD, Shore RE, Langholz B, Thomas DC, Bernstein L, Lynch CF, Olsen JH, Malone KE, Mellemkjaer L, Borresen-Dale AL, Rosenstein BS, Teraoka SN, Diep AT, Smith SA, Capanu M, Reiner AS, Liang X, Gatti RA, Concannon P, WECARE Study Collaborative Group
J Natl Cancer Inst. 2010
PubMed ID: 20305132
Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
Kodama M, Otsubo C, Hirota T, Yokota J, Enari M, Taya Y
Mol Cell Biol. 2010
PubMed ID: 20123963
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.
Bolderson E, Tomimatsu N, Richard DJ, Boucher D, Kumar R, Pandita TK, Burma S, Khanna KK
Nucleic Acids Res. 2010
PubMed ID: 20019063
Genetic polymorphisms in ATM, ERCC1, APE1 and iASPP genes and lung cancer risk in a population of southeast China.
Deng Q, Sheng L, Su D, Zhang L, Liu P, Lu K, Ma S
Med Oncol. 2010
PubMed ID: 20354815
ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response.
Jang ER, Choi JD, Park MA, Jeong G, Cho H, Lee JS
Exp Mol Med. 2010
PubMed ID: 20164679
Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway.
Rosato RR, Kolla SS, Hock SK, Almenara JA, Patel A, Amin S, Atadja P, Fisher PB, Dent P, Grant S
J Biol Chem. 2010
PubMed ID: 20065354
Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3'-untranslated region of ataxia telangiectasia mutated and Rad3-related (ATR) transcript.
Yang R, Zhan M, Nalabothula NR, Yang Q, Indig FE, Carrier F
J Biol Chem. 2010
PubMed ID: 20103595
Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence.
Reimann M, Lee S, Loddenkemper C, Dörr JR, Tabor V, Aichele P, Stein H, Dörken B, Jenuwein T, Schmitt CA
Cancer Cell. 2010
PubMed ID: 20227040
Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia.
Shi JY, Ren ZH, Jiao B, Xiao R, Yun HY, Chen B, Zhao WL, Zhu Q, Chen Z, Chen SJ
Int J Cancer. 2010
PubMed ID: 20232390
Isoform-specific p73 knockout mice reveal a novel role for {Delta}Np73 in the DNA damage response pathway.
Wilhelm MT, Rufini A, Wetzel MK, Tsuchihara K, Inoue S, Tomasini R, Itie-Youten A, Wakeham A, Arsenian-Henriksson M, Melino G, Kaplan DR, Miller FD, Mak TW
Genes Dev. 2010
PubMed ID: 20194434
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.
Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20160076
Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation.
Westbrook AM, Schiestl RH
Cancer Res. 2010
PubMed ID: 20179206
Genomic instability--an evolving hallmark of cancer.
Negrini S, Gorgoulis VG, Halazonetis TD
Nat Rev Mol Cell Biol. 2010
PubMed ID: 20177397
Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis.
Teoh N, Pyakurel P, Dan YY, Swisshelm K, Hou J, Mitchell C, Fausto N, Gu Y, Farrell G
Gastroenterology. 2010
PubMed ID: 19919837
Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer.
Bozhanov SS, Angelova SG, Krasteva ME, Markov TL, Christova SL, Gavrilov IG, Georgieva EI
J Cancer Res Clin Oncol. 2010
PubMed ID: 20177704
Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation.
Reddy JP, Peddibhotla S, Bu W, Zhao J, Haricharan S, Du YC, Podsypanina K, Rosen JM, Donehower LA, Li Y
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133707
ATM Polymorphisms Are Associated With Risk of Radiation-Induced Pneumonitis.
Zhang L, Yang M, Bi N, Fang M, Sun T, Ji W, Tan W, Zhao L, Yu D, Lin D, Wang L
Int J Radiat Oncol Biol Phys. 2010
PubMed ID: 20171797
ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo.
Dujka ME, Puebla-Osorio N, Tavana O, Sang M, Zhu C
Oncogene. 2010
PubMed ID: 19915617
Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity.
Zschenker O, Raabe A, Boeckelmann IK, Borstelmann S, Szymczak S, Wellek S, Rades D, Hoeller U, Ziegler A, Dikomey E, Borgmann K
Radiother Oncol. 2010
PubMed ID: 20170971
The intronic splicing code: multiple factors involved in ATM pseudoexon definition.
Dhir A, Buratti E, van Santen MA, Lührmann R, Baralle FE
EMBO J. 2010
PubMed ID: 20094034
ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.
Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K
J Biol Chem. 2010
PubMed ID: 19965871
53BP1 promotes ATM activity through direct interactions with the MRN complex.
Lee JH, Goodarzi AA, Jeggo PA, Paull TT
EMBO J. 2010
PubMed ID: 20010693
ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.
Williamson CT, Muzik H, Turhan AG, Zamò A, O'Connor MJ, Bebb DG, Lees-Miller SP
Mol Cancer Ther. 2010
PubMed ID: 20124459
Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.
Rotolo JA, Mesicek J, Maj J, Truman JP, Haimovitz-Friedman A, Kolesnick R, Fuks Z
Cancer Res. 2010
PubMed ID: 20086180
DNA damage signaling is activated during cancer progression in human colorectal carcinoma.
Oka K, Tanaka T, Enoki T, Yoshimura K, Ohshima M, Kubo M, Murakami T, Gondou T, Minami Y, Takemoto Y, Harada E, Tsushimi T, Li TS, Traganos F, Darzynkiewicz Z, Hamano K
Cancer Biol Ther. 2010
PubMed ID: 20023412
Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control.
Yang X, Wood PA, Hrushesky WJ
J Biol Chem. 2010
PubMed ID: 19996108
ATM is down-regulated by N-Myc-regulated microRNA-421.
Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20080624
CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells.
Yoshida K, Sugimoto N, Iwahori S, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M
J Cell Sci. 2010
PubMed ID: 20048340
Large T antigen promotes JC virus replication in G2-arrested cells by inducing ATM- and ATR-mediated G2 checkpoint signaling.
Orba Y, Suzuki T, Makino Y, Kubota K, Tanaka S, Kimura T, Sawa H
J Biol Chem. 2010
PubMed ID: 19903823
Role of the translocation partner in protection against AID-dependent chromosomal translocations.
Jankovic M, Robbiani DF, Dorsett Y, Eisenreich T, Xu Y, Tarakhovsky A, Nussenzweig A, Nussenzweig MC
Proc Natl Acad Sci U S A. 2010
PubMed ID: 19966290
ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage.
Bensimon A, Schmidt A, Ziv Y, Elkon R, Wang SY, Chen DJ, Aebersold R, Shiloh Y
Sci Signal. 2010
PubMed ID: 21139141
Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis.
Shin YH, Choi Y, Erdin SU, Yatsenko SA, Kloc M, Yang F, Wang PJ, Meistrich ML, Rajkovic A
PLoS Genet. 2010
PubMed ID: 21079677
ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot.
Sun J, Oma Y, Harata M, Kono K, Shima H, Kinomura A, Ikura T, Suzuki H, Mizutani S, Kanaar R, Tashiro S
PLoS One. 2010
PubMed ID: 21048951
The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.
Smith J, Tho LM, Xu N, Gillespie DA
Adv Cancer Res. 2010
PubMed ID: 21034966
Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis.
Jurado S, Smyth I, van Denderen B, Tenis N, Hammet A, Hewitt K, Ng JL, McNees CJ, Kozlov SV, Oka H, Kobayashi M, Conlan LA, Cole TJ, Yamamoto K, Taniguchi Y, Takeda S, Lavin MF, Heierhorst J
PLoS Genet. 2010
PubMed ID: 20975950
Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas.
Corbo V, Ritelli R, Barbi S, Funel N, Campani D, Bardelli A, Scarpa A
PLoS One. 2010
PubMed ID: 20838624
The association between ATM D1853N polymorphism and breast cancer susceptibility: a meta-analysis.
Gao LB, Pan XM, Sun H, Wang X, Rao L, Li LJ, Liang WB, Lv ML, Yang WZ, Zhang L
J Exp Clin Cancer Res. 2010
PubMed ID: 20799949
DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation.
Craig AL, Holcakova J, Finlan LE, Nekulova M, Hrstka R, Gueven N, DiRenzo J, Smith G, Hupp TR, Vojtesek B
Mol Cancer. 2010
PubMed ID: 20663147
Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation.
Yan D, Ng WL, Zhang X, Wang P, Zhang Z, Mo YY, Mao H, Hao C, Olson JJ, Curran WJ, Wang Y
PLoS One. 2010
PubMed ID: 20617180
Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice.
Lee S, Donehower LA, Herron AJ, Moore DD, Fu L
PLoS One. 2010
PubMed ID: 20539819
Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.
White JS, Choi S, Bakkenist CJ
Sci Signal. 2010
PubMed ID: 20516478
ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating.
Takahashi A, Mori E, Su X, Nakagawa Y, Okamoto N, Uemura H, Kondo N, Noda T, Toki A, Ejima Y, Chen DJ, Ohnishi K, Ohnishi T
J Radiat Res (Tokyo). 2010
PubMed ID: 20448412
Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants.
Adams BR, Golding SE, Rao RR, Valerie K
PLoS One. 2010
PubMed ID: 20368801
DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response.
Dejeux E, Rønneberg JA, Solvang H, Bukholm I, Geisler S, Aas T, Gut IG, Børresen-Dale AL, Lønning PE, Kristensen VN, Tost J
Mol Cancer. 2010
PubMed ID: 20338046
Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis.
Su F, Smilenov LB, Ludwig T, Zhou L, Zhu J, Zhou G, Hall EJ
Radiat Oncol. 2010
PubMed ID: 20175908
Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage.
Guerra L, Albihn A, Tronnersjö S, Yan Q, Guidi R, Stenerlöw B, Sterzenbach T, Josenhans C, Fox JG, Schauer DB, Thelestam M, Larsson LG, Henriksson M, Frisan T
PLoS One. 2010
PubMed ID: 20111719
Frequency and clinical relevance of DNA microsatellite alterations of the CDKN2A/B, ATM and p53 gene loci: a comparison between pediatric precursor T-cell lymphoblastic lymphoma and T-cell lymphoblastic leukemia.
Krieger D, Moericke A, Oschlies I, Zimmermann M, Schrappe M, Reiter A, Burkhardt B
Haematologica. 2010
PubMed ID: 19586936
Cytoplasmic ATM in neurons modulates synaptic function.
Li J, Han YR, Plummer MR, Herrup K
Curr Biol. 2009
PubMed ID: 19962314
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.
So S, Davis AJ, Chen DJ
J Cell Biol. 2009
PubMed ID: 20026654
TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells.
Vanderwerf SM, Svahn J, Olson S, Rathbun RK, Harrington C, Yates J, Keeble W, Anderson DC, Anur P, Pereira NF, Pilonetto DV, Pasquini R, Bagby GC
Blood. 2009
PubMed ID: 19850743
ATM activates p53 by regulating MDM2 oligomerization and E3 processivity.
Cheng Q, Chen L, Li Z, Lane WS, Chen J
EMBO J. 2009
PubMed ID: 19816404
Impaired skin and mammary gland development and increased gamma-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1.
Kim SS, Cao L, Baek HJ, Lim SC, Li C, Wang RH, Xu X, Cho KH, Deng CX
Cancer Res. 2009
PubMed ID: 19996295
ATM regulates a RASSF1A-dependent DNA damage response.
Hamilton G, Yee KS, Scrace S, O'Neill E
Curr Biol. 2009
PubMed ID: 19962312
ATM polymorphisms and risk of lung cancer among never smokers.
Lo YL, Hsiao CF, Jou YS, Chang GC, Tsai YH, Su WC, Chen YM, Huang MS, Chen HL, Yang PC, Chen CJ, Hsiung CA
Lung Cancer. 2009
PubMed ID: 20004998
A novel ataxia-telangiectasia mutated autoregulatory feedback mechanism in murine embryonic stem cells.
Clyde RG, Craig AL, de Breed L, Bown JL, Forrester L, Vojtesek B, Smith G, Hupp T, Crawford J
J R Soc Interface. 2009
PubMed ID: 19324671
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.
Das BB, Antony S, Gupta S, Dexheimer TS, Redon CE, Garfield S, Shiloh Y, Pommier Y
EMBO J. 2009
PubMed ID: 19851285
Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation.
Ray A, Mir SN, Wani G, Zhao Q, Battu A, Zhu Q, Wang QE, Wani AA
Mol Cell Biol. 2009
PubMed ID: 19805520
Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women.
Kontorovich T, Levy A, Korostishevsky M, Nir U, Friedman E
Int J Cancer. 2009
PubMed ID: 19950226
A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation.
Stilmann M, Hinz M, Arslan SC, Zimmer A, Schreiber V, Scheidereit C
Mol Cell. 2009
PubMed ID: 19917246
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.
Beucher A, Birraux J, Tchouandong L, Barton O, Shibata A, Conrad S, Goodarzi AA, Krempler A, Jeggo PA, Löbrich M
EMBO J. 2009
PubMed ID: 19779458
Mammalian Rif1 contributes to replication stress survival and homology-directed repair.
Buonomo SB, Wu Y, Ferguson D, de Lange T
J Cell Biol. 2009
PubMed ID: 19948482
Regulation of ATM in DNA double strand break repair accounts for the radiosensitivity in human cells exposed to high linear energy transfer ionizing radiation.
Xue L, Yu D, Furusawa Y, Okayasu R, Tong J, Cao J, Fan S
Mutat Res. 2009
PubMed ID: 19583974
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells.
Zhu H, Miao ZH, Huang M, Feng JM, Zhang ZX, Lu JJ, Cai YJ, Tong LJ, Xu YF, Qian XH, Ding J
Neoplasia. 2009
PubMed ID: 19881958
Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis.
Mahowald GK, Baron JM, Mahowald MA, Kulkarni S, Bredemeyer AL, Bassing CH, Sleckman BP
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19820166
Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation.
Moody CA, Laimins LA
PLoS Pathog. 2009
PubMed ID: 19798429
A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.
Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD
Postgrad Med J. 2009
PubMed ID: 19789190
Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer.
Tavtigian SV, Oefner PJ, Babikyan D, Hartmann A, Healey S, Le Calvez-Kelm F, Lesueur F, Byrnes GB, Chuang SC, Forey N, Feuchtinger C, Gioia L, Hall J, Hashibe M, Herte B, McKay-Chopin S, Thomas A, Vallée MP, Voegele C, Webb PM, Whiteman DC, Australian Cancer Study, Breast Cancer Family Registries (BCFR), Kathleen Cuningham Foundation Consortium for Research into Familial Aspects of Breast Cancer (kConFab), Sangrajrang S, Hopper JL, Southey MC, Andrulis IL, John EM, Chenevix-Trench G
Am J Hum Genet. 2009
PubMed ID: 19781682
ATM and ATR protect the genome against two different types of tandem repeat instability in Fragile X premutation mice.
Entezam A, Usdin K
Nucleic Acids Res. 2009
PubMed ID: 19710035
Oxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line.
Pizarro JG, Folch J, Vazquez De la Torre A, Verdaguer E, Junyent F, Jordán J, Pallàs M, Camins A
Free Radic Res. 2009
PubMed ID: 19657808
Bleomycin-induced over-replication involves sustained inhibition of mitotic entry through the ATM/ATR pathway.
Nakayama Y, Igarashi A, Kikuchi I, Obata Y, Fukumoto Y, Yamaguchi N
Exp Cell Res. 2009
PubMed ID: 19527713
Founder effects for ATM gene mutations in Italian Ataxia Telangiectasia families.
Chessa L, Piane M, Magliozzi M, Torrente I, Savio C, Lulli P, De Luca A, Dallapiccola B
Ann Hum Genet. 2009
PubMed ID: 19691550
Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.
McWilliams RR, Bamlet WR, de Andrade M, Rider DN, Couch FJ, Cunningham JM, Matsumoto ME, Rabe KG, Hammer TJ, Petersen GM
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19690177
Detection of gene copy number aberrations in mantle cell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value.
Jardin F, Picquenot JM, Parmentier F, Ruminy P, Cornic M, Penther D, Bertrand P, Lanic H, Cassuto O, Humbrecht C, Lemasle E, Wautier A, Bastard C, Tilly H
Br J Haematol. 2009
PubMed ID: 19594747
Breaks invisible to the DNA damage response machinery accumulate in ATM-deficient cells.
Martín M, Terradas M, Iliakis G, Tusell L, Genescà A
Genes Chromosomes Cancer. 2009
PubMed ID: 19455703
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency.
Cao L, Xu X, Bunting SF, Liu J, Wang RH, Cao LL, Wu JJ, Peng TN, Chen J, Nussenzweig A, Deng CX, Finkel T
Mol Cell. 2009
PubMed ID: 19716796
The combined status of ATM and p53 link tumor development with therapeutic response.
Jiang H, Reinhardt HC, Bartkova J, Tommiska J, Blomqvist C, Nevanlinna H, Bartek J, Yaffe MB, Hemann MT
Genes Dev. 2009
PubMed ID: 19608766
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Mechanism of beta-carotene-induced apoptosis of gastric cancer cells: involvement of ataxia-telangiectasia-mutated.
Jang SH, Lim JW, Kim H
Ann N Y Acad Sci. 2009
PubMed ID: 19723050
A common 9 bp deletion in the ataxia-telangiectasia-mutated gene is not associated with oral cancer.
Spyridonidou S, Yapijakis C, Nkenke E, Toyoshima T, Vylliotis A, Serefoglou Z, Neukam FW, Patsouris E, Vairaktaris E
Anticancer Res. 2009
PubMed ID: 19661334
Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients.
Pugh TJ, Keyes M, Barclay L, Delaney A, Krzywinski M, Thomas D, Novik K, Yang C, Agranovich A, McKenzie M, Morris WJ, Olive PL, Marra MA, Moore RA
Clin Cancer Res. 2009
PubMed ID: 19638463
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.
Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J
Nat Cell Biol. 2009
PubMed ID: 19597488
Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks.
Sordet O, Redon CE, Guirouilh-Barbat J, Smith S, Solier S, Douarre C, Conti C, Nakamura AJ, Das BB, Nicolas E, Kohn KW, Bonner WM, Pommier Y
EMBO Rep. 2009
PubMed ID: 19557000
A unique lethal blastoid transformation of B-cell chronic lymphocytic leukemia carrying ATM/11q deletion and trisomy 12.
Lu Y, Huang Q
Leuk Res. 2009
PubMed ID: 19269030
Elevated lung cancer risk is associated with deficiencies in cell cycle checkpoints: Genotype and phenotype analyses from a case-control study.
Zheng YL, Kosti O, Loffredo C, Bowman E, Mechanic L, Perlmutter D, Jones R, Shields PG, Harris C
Int J Cancer. 2009
PubMed ID: 19626602
Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.
Kweekel DM, Antonini NF, Nortier JW, Punt CJ, Gelderblom H, Guchelaar HJ
Br J Cancer. 2009
PubMed ID: 19536092
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.
Rebbeck TR, Mitra N, Domchek SM, Wan F, Chuai S, Friebel TM, Panossian S, Spurdle A, Chenevix-Trench G, kConFab, Singer CF, Pfeiler G, Neuhausen SL, Lynch HT, Garber JE, Weitzel JN, Isaacs C, Couch F, Narod SA, Rubinstein WS, Tomlinson GE, Ganz PA, Olopade OI, Tung N, Blum JL, Greenberg R, Nathanson KL, Daly MB
Cancer Res. 2009
PubMed ID: 19584272
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
Sfeir A, Kosiyatrakul ST, Hockemeyer D, MacRae SL, Karlseder J, Schildkraut CL, de Lange T
Cell. 2009
PubMed ID: 19596237
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
Promoter methylation patterns of ATM, ATR, BRCA1, BRCA2 and P53 as putative cancer risk modifiers in Jewish BRCA1/BRCA2 mutation carriers.
Kontorovich T, Cohen Y, Nir U, Friedman E
Breast Cancer Res Treat. 2009
PubMed ID: 18642075
The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.
Barroso E, Pita G, Arias JI, Menendez P, Zamora P, Blanco M, Benitez J, Ribas G
Breast Cancer Res Treat. 2009
PubMed ID: 19536649
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.
Inomata K, Aoto T, Binh NT, Okamoto N, Tanimura S, Wakayama T, Iseki S, Hara E, Masunaga T, Shimizu H, Nishimura EK
Cell. 2009
PubMed ID: 19524511
Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis.
Shao L, Fujii H, Colmegna I, Oishi H, Goronzy JJ, Weyand CM
J Exp Med. 2009
PubMed ID: 19451263
Deregulation of mTOR signaling is involved in thymic lymphoma development in Atm-/- mice.
Kuang X, Shen J, Wong PK, Yan M
Biochem Biophys Res Commun. 2009
PubMed ID: 19364503
The CXXC finger 5 protein is required for DNA damage-induced p53 activation.
ZHANG M, WANG R, WANG Y, DIAO F, LU F, GAO D, CHEN D, ZHAI Z, SHU H
Sci China C Life Sci. 2009
PubMed ID: 19557330
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.
Hewitt SL, Yin B, Ji Y, Chaumeil J, Marszalek K, Tenthorey J, Salvagiotto G, Steinel N, Ramsey LB, Ghysdael J, Farrar MA, Sleckman BP, Schatz DG, Busslinger M, Bassing CH, Skok JA
Nat Immunol. 2009
PubMed ID: 19448632
Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.
Tomimatsu N, Mukherjee B, Burma S
EMBO Rep. 2009
PubMed ID: 19444312
Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.
Derudder E, Cadera EJ, Vahl JC, Wang J, Fox CJ, Zha S, van Loo G, Pasparakis M, Schlissel MS, Schmidt-Supprian M, Rajewsky K
Nat Immunol. 2009
PubMed ID: 19412180
Description and validation of high-throughput simultaneous genotyping and mutation scanning by high-resolution melting curve analysis.
Nguyen-Dumont T, Calvez-Kelm FL, Forey N, McKay-Chopin S, Garritano S, Gioia-Patricola L, De Silva D, Weigel R, Sangrajrang S, Lesueur F, Tavtigian SV, Breast Cancer Family Registries (BCFR), Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab)
Hum Mutat. 2009
PubMed ID: 19347964
Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma.
Akulevich NM, Saenko VA, Rogounovitch TI, Drozd VM, Lushnikov EF, Ivanov VK, Mitsutake N, Kominami R, Yamashita S
Endocr Relat Cancer. 2009
PubMed ID: 19286843
DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression.
Carlessi L, De Filippis L, Lecis D, Vescovi A, Delia D
Cell Death Differ. 2009
PubMed ID: 19229246
Oxidative stress is linked to ERK1/2-p16 signaling-mediated growth defect in ATM-deficient astrocytes.
Kim J, Wong PK
J Biol Chem. 2009
PubMed ID: 19321450
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.
Savic V, Yin B, Maas NL, Bredemeyer AL, Carpenter AC, Helmink BA, Yang-Iott KS, Sleckman BP, Bassing CH
Mol Cell. 2009
PubMed ID: 19450528
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.
Callén E, Jankovic M, Wong N, Zha S, Chen HT, Difilippantonio S, Di Virgilio M, Heidkamp G, Alt FW, Nussenzweig A, Nussenzweig M
Mol Cell. 2009
PubMed ID: 19450527
Modes of p53 regulation.
Kruse JP, Gu W
Cell. 2009
PubMed ID: 19450511
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells.
Sahu RP, Batra S, Srivastava SK
Br J Cancer. 2009
PubMed ID: 19401701
Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.
Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Méjean A, Desgrandchamps F, Lathrop M, Sarasin A, Benhamou S
Carcinogenesis. 2009
PubMed ID: 19237606
The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1.
Parfitt DA, Michael GJ, Vermeulen EG, Prodromou NV, Webb TR, Gallo JM, Cheetham ME, Nicoll WS, Blatch GL, Chapple JP
Hum Mol Genet. 2009
PubMed ID: 19208651
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
ATM germline mutations in women with familial breast cancer and a relative with haematological malignancy.
Paglia LL, Laugé A, Weber J, Champ J, Cavaciuti E, Russo A, Viovy JL, Stoppa-Lyonnet D
Breast Cancer Res Treat. 2009
PubMed ID: 19404735
Genetic mutations associated with cigarette smoking in pancreatic cancer.
Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH
Cancer Res. 2009
PubMed ID: 19351817
Silencing the Metallothionein-2A gene inhibits cell cycle progression from G1- to S-phase involving ATM and cdc25A signaling in breast cancer cells.
Lim D, Jocelyn KM, Yip GW, Bay BH
Cancer Lett. 2009
PubMed ID: 19062161
Antaxia-telangiectasia mutated gene polymorphisms and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons exposed workers.
Wang Y, Duan H, Dai Y, Bin P, Cheng J, Pan Z, Huang C, Leng S, Zheng Y
Sci Total Environ. 2009
PubMed ID: 19193393
Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients.
Flanagan JM, Munoz-Alegre M, Henderson S, Tang T, Sun P, Johnson N, Fletcher O, Dos Santos Silva I, Peto J, Boshoff C, Narod S, Petronis A
Hum Mol Genet. 2009
PubMed ID: 19153073
Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1.
Kobayashi J, Tauchi H, Chen B, Burma S, Bruma S, Tashiro S, Matsuura S, Tanimoto K, Chen DJ, Komatsu K
Biochem Biophys Res Commun. 2009
PubMed ID: 19338747
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.
Helmink BA, Bredemeyer AL, Lee BS, Huang CY, Sharma GG, Walker LM, Bednarski JJ, Lee WL, Pandita TK, Bassing CH, Sleckman BP
J Exp Med. 2009
PubMed ID: 19221393
Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks.
Shiotani B, Zou L
Mol Cell. 2009
PubMed ID: 19285939
ATM blocks tunicamycin-induced endoplasmic reticulum stress.
He L, Kim SO, Kwon O, Jeong SJ, Kim MS, Lee HG, Osada H, Jung M, Ahn JS, Kim BY
FEBS Lett. 2009
PubMed ID: 19302790
ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia.
Grosjean-Raillard J, Tailler M, Adès L, Perfettini JL, Fabre C, Braun T, De Botton S, Fenaux P, Kroemer G
Oncogene. 2009
PubMed ID: 19079347
ATM-mediated transcriptional elevation of prion in response to copper-induced oxidative stress.
Qin K, Zhao L, Ash RD, McDonough WF, Zhao RY
J Biol Chem. 2009
PubMed ID: 19064990
Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death.
Tian B, Yang Q, Mao Z
Nat Cell Biol. 2009
PubMed ID: 19151707
Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair.
Kirshner M, Rathavs M, Nizan A, Essers J, Kanaar R, Shiloh Y, Barzilai A
DNA Repair (Amst). 2009
PubMed ID: 19061978
Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated Modulator of Apoptosis.
Li W, Du B, Wang T, Wang S, Zhang J
Chem Biol Interact. 2009
PubMed ID: 19028473
DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases.
Yajima H, Lee KJ, Zhang S, Kobayashi J, Chen BP
J Mol Biol. 2009
PubMed ID: 19071136
ATM is required for rapid degradation of cyclin D1 in response to gamma-irradiation.
Choo DW, Baek HJ, Motoyama N, Cho KH, Kim HS, Kim SS
Biochem Biophys Res Commun. 2009
PubMed ID: 19071090
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.
Shull ER, Lee Y, Nakane H, Stracker TH, Zhao J, Russell HR, Petrini JH, McKinnon PJ
Genes Dev. 2009
PubMed ID: 19171781
DNA repair gene polymorphisms and risk of pancreatic cancer.
Li D, Suzuki H, Liu B, Morris J, Liu J, Okazaki T, Li Y, Chang P, Abbruzzese JL
Clin Cancer Res. 2009
PubMed ID: 19147782
Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice.
Tsuji H, Ishii-Ohba H, Noda Y, Kubo E, Furuse T, Tatsumi K
Mutat Res. 2009
PubMed ID: 19000702
A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.
Vineis P, Manuguerra M, Kavvoura FK, Guarrera S, Allione A, Rosa F, Di Gregorio A, Polidoro S, Saletta F, Ioannidis JP, Matullo G
J Natl Cancer Inst. 2009
PubMed ID: 19116388
S1219 residue of 53BP1 is phosphorylated by ATM kinase upon DNA damage and required for proper execution of DNA damage response.
Lee H, Kwak HJ, Cho IT, Park SH, Lee CH
Biochem Biophys Res Commun. 2009
PubMed ID: 18996087
DNA double strand break repair enzymes function at multiple steps in retroviral infection.
Sakurai Y, Komatsu K, Agematsu K, Matsuoka M
Retrovirology. 2009
PubMed ID: 20003485
Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.
Efeyan A, Murga M, Martinez-Pastor B, Ortega-Molina A, Soria R, Collado M, Fernandez-Capetillo O, Serrano M
PLoS One. 2009
PubMed ID: 19421407
ATM localization and gene expression in the adult mouse eye.
Leemput J, Masson C, Bigot K, Errachid A, Dansault A, Provost A, Gadin S, Aoufouchi S, Menasche M, Abitbol M
Mol Vis. 2009
PubMed ID: 19234633
Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
Mavaddat N, Dunning AM, Ponder BA, Easton DF, Pharoah PD
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19124506
Activation of ATM depends on chromatin interactions occurring before induction of DNA damage.
Kim YC, Gerlitz G, Furusawa T, Catez F, Nussenzweig A, Oh KS, Kraemer KH, Shiloh Y, Bustin M
Nat Cell Biol. 2009
PubMed ID: 19079244
DNA-PK suppresses a p53-independent apoptotic response to DNA damage.
Gurley KE, Moser R, Gu Y, Hasty P, Kemp CJ
EMBO Rep. 2009
PubMed ID: 19057578
PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo.
Truman JP, Rotenberg SA, Kang JH, Lerman G, Fuks Z, Kolesnick R, Marquez VE, Haimovitz-Friedman A
Cancer Biol Ther. 2009
PubMed ID: 19029835
Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.
Stracker TH, Williams BR, Deriano L, Theunissen JW, Adelman CA, Roth DB, Petrini JH
Mol Cell Biol. 2009
PubMed ID: 19015239
ATM activation and signaling under hypoxic conditions.
Bencokova Z, Kaufmann MR, Pires IM, Lecane PS, Giaccia AJ, Hammond EM
Mol Cell Biol. 2009
PubMed ID: 18981219
Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population.
Zhang F, Xu Y, Liu P, Fan H, Huang X, Sun G, Song Y, Sham PC
BMC Med Genet. 2008
PubMed ID: 19115993
Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Enjuanes A, Benavente Y, Bosch F, Martín-Guerrero I, Colomer D, Pérez-Alvarez S, Reina O, Ardanaz MT, Jares P, García-Orad A, Pujana MA, Montserrat E, de Sanjosé S, Campo E
Cancer Res. 2008
PubMed ID: 19074885
SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint.
Akhter S, Legerski RJ
Biochem Biophys Res Commun. 2008
PubMed ID: 18848520
DNA-PKcs and ATM influence generation of ionizing radiation-induced bystander signals.
Hagelstrom RT, Askin KF, Williams AJ, Ramaiah L, Desaintes C, Goodwin EH, Ullrich RL, Bailey SM
Oncogene. 2008
PubMed ID: 18679419
Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064572
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo.
Daniel JA, Pellegrini M, Lee JH, Paull TT, Feigenbaum L, Nussenzweig A
J Cell Biol. 2008
PubMed ID: 19047460
ATM and Chk2 kinase target the p53 cofactor Strap.
Adams CJ, Graham AL, Jansson M, Coutts AS, Edelmann M, Smith L, Kessler B, La Thangue NB
EMBO Rep. 2008
PubMed ID: 18833288
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility.
Dimitrova N, Chen YC, Spector DL, de Lange T
Nature. 2008
PubMed ID: 18931659
ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage.
Chang L, Zhou B, Hu S, Guo R, Liu X, Jones SN, Yen Y
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19015526
Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background.
Mao JH, Wu D, DelRosario R, Castellanos A, Balmain A, Perez-Losada J
Oncogene. 2008
PubMed ID: 18679420
DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization.
Di Micco R, Cicalese A, Fumagalli M, Dobreva M, Verrecchia A, Pelicci PG, di Fagagna F
Cell Cycle. 2008
PubMed ID: 19001874
Tissue-specific DNA-PK-dependent H2AX phosphorylation and gamma-H2AX elimination after X-irradiation in vivo.
Koike M, Sugasawa J, Yasuda M, Koike A
Biochem Biophys Res Commun. 2008
PubMed ID: 18755145
Breast cancer incidence and the effect of cigarette smoking in heterozygous carriers of mutations in the ataxia-telangiectasia gene.
Swift M, Lukin JL
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18990761
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.
Ishiai M, Kitao H, Smogorzewska A, Tomida J, Kinomura A, Uchida E, Saberi A, Kinoshita E, Kinoshita-Kikuta E, Koike T, Tashiro S, Elledge SJ, Takata M
Nat Struct Mol Biol. 2008
PubMed ID: 18931676
Three-hit hypothesis in astrocytoma: tracing the polymorphism D1853N in ATM gene through a pedigree of the proband affected with primary brain tumor.
Mehdipour P, Habibi L, Mohammadi-Asl J, Kamalian N, Mehr Azin M
J Cancer Res Clin Oncol. 2008
PubMed ID: 18465141
Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: A two-stage Spanish case-control study.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A
Gynecol Oncol. 2008
PubMed ID: 18950845
The HINT1 tumor suppressor regulates both gamma-H2AX and ATM in response to DNA damage.
Li H, Balajee AS, Su T, Cen B, Hei TK, Weinstein IB
J Cell Biol. 2008
PubMed ID: 18852295
Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects.
Derradji H, Bekaert S, De Meyer T, Jacquet P, Abou-El-Ardat K, Ghardi M, Arlette M, Baatout S
Dev Biol. 2008
PubMed ID: 18722365
Identification and characterization of FUS/TLS as a new target of ATM.
Gardiner M, Toth R, Vandermoere F, Morrice NA, Rouse J
Biochem J. 2008
PubMed ID: 18620545
ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.
Ewald B, Sampath D, Plunkett W
Cancer Res. 2008
PubMed ID: 18829552
Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy.
Azria D, Ozsahin M, Kramar A, Peters S, Atencio DP, Crompton NE, Mornex F, Pèlegrin A, Dubois JB, Mirimanoff RO, Rosenstein BS
Clin Cancer Res. 2008
PubMed ID: 18829510
Phosphorylation of p53 on Ser15 during cell cycle caused by Topo I and Topo II inhibitors in relation to ATM and Chk2 activation.
Zhao H, Traganos F, Darzynkiewicz Z
Cell Cycle. 2008
PubMed ID: 18802408
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Potency and property of DNA conformational damage determine ATM activation: two new DNA topological probes.
Zhang Z, Wang Y, Zhang J, Song T, Qian X
Cell Biochem Funct. 2008
PubMed ID: 18788070
A role for DEAD box 1 at DNA double-strand breaks.
Li L, Monckton EA, Godbout R
Mol Cell Biol. 2008
PubMed ID: 18710941
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.
Ariumi Y, Kuroki M, Dansako H, Abe K, Ikeda M, Wakita T, Kato N
J Virol. 2008
PubMed ID: 18667510
DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks.
Yu Y, Mahaney BL, Yano K, Ye R, Fang S, Douglas P, Chen DJ, Lees-Miller SP
DNA Repair (Amst). 2008
PubMed ID: 18644470
Statins use a novel Nijmegen breakage syndrome-1-dependent pathway to accelerate DNA repair in vascular smooth muscle cells.
Mahmoudi M, Gorenne I, Mercer J, Figg N, Littlewood T, Bennett M
Circ Res. 2008
PubMed ID: 18723444
A nonsense mutation (E1978X) in the ATM gene is associated with breast cancer.
Bogdanova N, Cybulski C, Bermisheva M, Datsyuk I, Yamini P, Hillemanns P, Antonenkova NN, Khusnutdinova E, Lubinski J, Dörk T
Breast Cancer Res Treat. 2008
PubMed ID: 18807267
ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage.
Huang Y, Sen T, Nagpal J, Upadhyay S, Trink B, Ratovitski E, Sidransky D
Cell Cycle. 2008
PubMed ID: 18769144
Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.
Yalcin S, Zhang X, Luciano JP, Mungamuri SK, Marinkovic D, Vercherat C, Sarkar A, Grisotto M, Taneja R, Ghaffari S
J Biol Chem. 2008
PubMed ID: 18424439
NBS1 prevents chromatid-type aberrations through ATM-dependent interactions with SMC1.
Antoccia A, Sakamoto S, Matsuura S, Tauchi H, Komatsu K
Radiat Res. 2008
PubMed ID: 18763866
ATM acts downstream of ATR in the DNA damage response signaling of bystander cells.
Burdak-Rothkamm S, Rothkamm K, Prise KM
Cancer Res. 2008
PubMed ID: 18757420
Phosphorylation of cyclin D1 regulated by ATM or ATR controls cell cycle progression.
Hitomi M, Yang K, Stacey AW, Stacey DW
Mol Cell Biol. 2008
PubMed ID: 18606783
WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks.
Cheng WH, Muftic D, Muftuoglu M, Dawut L, Morris C, Helleday T, Shiloh Y, Bohr VA
Mol Biol Cell. 2008
PubMed ID: 18596239
Pathogenic ATM mutations occur rarely in a subset of multiple myeloma patients.
Austen B, Barone G, Reiman A, Byrd PJ, Baker C, Starczynski J, Nobbs MC, Murphy RP, Enright H, Chaila E, Quinn J, Stankovic T, Pratt G, Taylor AM
Br J Haematol. 2008
PubMed ID: 18573109
The effects of Atm haploinsufficiency on mutation rate in the mouse germ line and somatic tissue.
Ahuja AK, Barber RC, Hardwick RJ, Weil MM, Genik PC, Brenner DJ, Dubrova YE
Mutagenesis. 2008
PubMed ID: 18499649
ATM in oral carcinogenesis: association with clinicopathological features.
He Y, Chen Q, Li B
J Cancer Res Clin Oncol. 2008
PubMed ID: 18288488
Transgenic expression of E2F3a causes DNA damage leading to ATM-dependent apoptosis.
Paulson QX, Pusapati RV, Hong S, Weaks RL, Conti CJ, Johnson DG
Oncogene. 2008
PubMed ID: 18469863
Variants in the ATM gene associated with a reduced risk of contralateral breast cancer.
Concannon P, Haile RW, Børresen-Dale AL, Rosenstein BS, Gatti RA, Teraoka SN, Diep TA, Jansen L, Atencio DP, Langholz B, Capanu M, Liang X, Begg CB, Thomas DC, Bernstein L, Olsen JH, Malone KE, Lynch CF, Anton-Culver H, Bernstein JL, Women's Environment, Cancer, and Radiation Epidemiology Study Collaborative Group
Cancer Res. 2008
PubMed ID: 18701470
Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining.
Bredemeyer AL, Huang CY, Walker LM, Bassing CH, Sleckman BP
J Immunol. 2008
PubMed ID: 18684952
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
Endogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation.
Demuth I, Bradshaw PS, Lindner A, Anders M, Heinrich S, Kallenbach J, Schmelz K, Digweed M, Meyn MS, Concannon P
DNA Repair (Amst). 2008
PubMed ID: 18468965
ATM gene mutations result in both recessive and dominant expression phenotypes of genes and microRNAs.
Smirnov DA, Cheung VG
Am J Hum Genet. 2008
PubMed ID: 18674748
Immunodeficiency in ataxia telangiectasia is correlated strongly with the presence of two null mutations in the ataxia telangiectasia mutated gene.
Staples ER, McDermott EM, Reiman A, Byrd PJ, Ritchie S, Taylor AM, Davies EG
Clin Exp Immunol. 2008
PubMed ID: 18505428
A role for E1B-AP5 in ATR signaling pathways during adenovirus infection.
Blackford AN, Bruton RK, Dirlik O, Stewart GS, Taylor AM, Dobner T, Grand RJ, Turnell AS
J Virol. 2008
PubMed ID: 18480432
Osteolineage niche cells initiate hematopoietic stem cell mobilization.
Mayack SR, Wagers AJ
Blood. 2008
PubMed ID: 18456874
Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study.
Sasaki M, Ikeda H, Nakanuma Y
J Autoimmun. 2008
PubMed ID: 18456456
Single nucleotide polymorphism D1853N of the ATM gene may alter the risk for breast cancer.
Schrauder M, Frank S, Strissel PL, Lux MP, Bani MR, Rauh C, Sieber CC, Heusinger K, Hartmann A, Schulz-Wendtland R, Strick R, Beckmann MW, Fasching PA
J Cancer Res Clin Oncol. 2008
PubMed ID: 18264724
Detection of ATM gene deletion/duplication by multiplex ligation-dependant probe amplification in childhood lymphoid malignancies: a report from the Children's Oncology Group.
Gumy-Pause F, Ozsahin H, Khoshbeen-Boudal M, Betts DR, Maillet P, Sappino AP
Leuk Res. 2008
PubMed ID: 18261794
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.
Goodarzi AA, Noon AT, Deckbar D, Ziv Y, Shiloh Y, Löbrich M, Jeggo PA
Mol Cell. 2008
PubMed ID: 18657500
Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity.
Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V
EMBO J. 2008
PubMed ID: 18596698
Functional and computational assessment of missense variants in the ataxia-telangiectasia mutated (ATM) gene: mutations with increased cancer risk.
Mitui M, Nahas SA, Du LT, Yang Z, Lai CH, Nakamura K, Arroyo S, Scott S, Purayidom A, Concannon P, Lavin M, Gatti RA
Hum Mutat. 2008
PubMed ID: 18634022
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage.
Stracker TH, Couto SS, Cordon-Cardo C, Matos T, Petrini JH
Mol Cell. 2008
PubMed ID: 18614044
Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase.
Jin J, Ang XL, Ye X, Livingstone M, Harper JW
J Biol Chem. 2008
PubMed ID: 18480045
Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3.
Luo H, Li Y, Mu JJ, Zhang J, Tonaka T, Hamamori Y, Jung SY, Wang Y, Qin J
J Biol Chem. 2008
PubMed ID: 18442975
Complementary functions of ATM and H2AX in development and suppression of genomic instability.
Zha S, Sekiguchi J, Brush JW, Bassing CH, Alt FW
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18599436
Aven-dependent activation of ATM following DNA damage.
Guo JY, Yamada A, Kajino T, Wu JQ, Tang W, Freel CD, Feng J, Chau BN, Wang MZ, Margolis SS, Yoo HY, Wang XF, Dunphy WG, Irusta PM, Hardwick JM, Kornbluth S
Curr Biol. 2008
PubMed ID: 18571408
hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress.
Gehen SC, Staversky RJ, Bambara RA, Keng PC, O'Reilly MA
Oncogene. 2008
PubMed ID: 18332866
[Prognostic significance of p53 and ATM gene deletion in patients with chronic lymphocytic leukemia]
Xu W, Li JY, Li L, Wu YJ, Yu H, Shen QD, Qiu HX
Zhonghua Xue Ye Xue Za Zhi. 2008
PubMed ID: 19035176
Genotype-phenotype relationship between DNA repair gene genetic polymorphisms and DNA repair capacity.
Shin A, Lee KM, Ahn B, Park CG, Noh SK, Park DY, Ahn SH, Yoo KY, Kang D
Asian Pac J Cancer Prev. 2008
PubMed ID: 18990028
Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: a culture study.
Sasaki M, Ikeda H, Sato Y, Nakanuma Y
Free Radic Res. 2008
PubMed ID: 18608517
ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells.
Stohr BA, Blackburn EH
Cancer Res. 2008
PubMed ID: 18593932
Tumor suppression by p53 in the absence of Atm.
Bailey SL, Gurley KE, Hoon-Kim K, Kelly-Spratt KS, Kemp CJ
Mol Cancer Res. 2008
PubMed ID: 18583527
Genetic polymorphisms in double-strand break DNA repair genes associated with risk of oral premalignant lesions.
Yang H, Lippman SM, Huang M, Jack Lee J, Wang W, Spitz MR, Wu X
Eur J Cancer. 2008
PubMed ID: 18579371
Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.
Winter M, Sombroek D, Dauth I, Moehlenbrink J, Scheuermann K, Crone J, Hofmann TG
Nat Cell Biol. 2008
PubMed ID: 18536714
Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response.
Chandhasin C, Ducu RI, Berkovich E, Kastan MB, Marriott SJ
J Virol. 2008
PubMed ID: 18434398
Prognostic significance of ATM and TP53 deletions in Chinese patients with chronic lymphocytic leukemia.
Xu W, Li JY, Wu YJ, Yu H, Shen QD, Li L, Fan L, Qiu HX
Leuk Res. 2008
PubMed ID: 18035414
Risk of cancer by ATM missense mutations in the general population.
Dombernowsky SL, Weischer M, Allin KH, Bojesen SE, Tybjjrg-Hansen A, Nordestgaard BG
J Clin Oncol. 2008
PubMed ID: 18565893
Regulation of TIP60 by ATF2 modulates ATM activation.
Bhoumik A, Singha N, O'Connell MJ, Ronai ZA
J Biol Chem. 2008
PubMed ID: 18397884
Contribution of mutations in ATM to breast cancer development in the Czech population.
Soukupova J, Dundr P, Kleibl Z, Pohlreich P
Oncol Rep. 2008
PubMed ID: 18497957
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.
Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK
Nature. 2008
PubMed ID: 18449195
ATM Gene Variants in Patients with Idiopathic Perifoveal Telangiectasia.
Barbazetto IA, Room M, Yannuzzi NA, Barile GR, Merriam JE, Bardal AM, Freund KB, Yannuzzi LA, Allikmets R
Invest Ophthalmol Vis Sci. 2008
PubMed ID: 18502988
Determination of three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with ATM.
Kim KJ, Park MC, Choi SJ, Oh YS, Choi EC, Cho HJ, Kim MH, Kim SH, Kim DW, Kim S, Kang BS
J Biol Chem. 2008
PubMed ID: 18343821
[P53-independent apoptosis through a novel ATM/IKK-alpha/p73-mediated apoptotic pathway]
Ozaki T, Nakagawara A
Seikagaku. 2008
PubMed ID: 18575226
ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes.
Barchi M, Roig I, Di Giacomo M, de Rooij DG, Keeney S, Jasin M
PLoS Genet. 2008
PubMed ID: 18497861
Tagging single nucleotide polymorphisms in phosphoinositide-3-kinase-related protein kinase genes involved in DNA damage "checkpoints" and lung cancer susceptibility.
Hu Z, Liu H, Wang H, Miao R, Sun W, Jin G, Wang Y, Ma H, Jin L, Wei Q, Lu D, Huang W, Shen H
Clin Cancer Res. 2008
PubMed ID: 18451257
Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity.
White JS, Choi S, Bakkenist CJ
Cell Cycle. 2008
PubMed ID: 18418045
ATM germline mutations in Spanish early-onset breast cancer patients negative for BRCA1/BRCA2 mutations.
Brunet J, Gutiérrez-Enríquez S, Torres A, Bérez V, Sanjosé S, Galceran J, Izquierdo A, Menéndez JA, Gumà J, Borràs J
Clin Genet. 2008
PubMed ID: 18384426
Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation.
Kulkarni A, Das KC
Am J Physiol Lung Cell Mol Physiol. 2008
PubMed ID: 18344416
The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer.
Tommiska J, Bartkova J, Heinonen M, Hautala L, Kilpivaara O, Eerola H, Aittomäki K, Hofstetter B, Lukas J, von Smitten K, Blomqvist C, Ristimäki A, Heikkilä P, Bartek J, Nevanlinna H
Oncogene. 2008
PubMed ID: 17982490
Interplay between ATM and ATR in the regulation of common fragile site stability.
Ozeri-Galai E, Schwartz M, Rahat A, Kerem B
Oncogene. 2008
PubMed ID: 17934520
Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer.
Okazaki T, Jiao L, Chang P, Evans DB, Abbruzzese JL, Li D
Clin Cancer Res. 2008
PubMed ID: 18381943
DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions.
Morales M, Liu Y, Laiakis EC, Morgan WF, Nimer SD, Petrini JH
Cancer Res. 2008
PubMed ID: 18381424
Functional interaction between FOXO3a and ATM regulates DNA damage response.
Tsai WB, Chung YM, Takahashi Y, Xu Z, Hu MC
Nat Cell Biol. 2008
PubMed ID: 18344987
A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage.
Tang X, Hui ZG, Cui XL, Garg R, Kastan MB, Xu B
Mol Cell Biol. 2008
PubMed ID: 18250156
Ionizing radiation can induce GSK-3beta phosphorylation and NF-kappaB transcriptional transactivation in ATM-deficient fibroblasts.
Kwon O, Kim KA, He L, Kim SO, Kim MS, Cha EY, Yoon BD, Sok DE, Jung M, Ahn JS, Kim BY
Cell Signal. 2008
PubMed ID: 18243662
Effects of antioxidants on cancer prevention and neuromotor performance in Atm deficient mice.
Reliene R, Fleming SM, Chesselet MF, Schiestl RH
Food Chem Toxicol. 2008
PubMed ID: 18037553
DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.
Franco S, Murphy MM, Li G, Borjeson T, Boboila C, Alt FW
J Exp Med. 2008
PubMed ID: 18316419
ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis.
Pabla N, Huang S, Mi QS, Daniel R, Dong Z
J Biol Chem. 2008
PubMed ID: 18162465
Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.
Sivasubramaniam S, Sun X, Pan YR, Wang S, Lee EY
Genes Dev. 2008
PubMed ID: 18283122
Upregulated ATM gene expression and activated DNA crosslink-induced damage response checkpoint in Fanconi anemia: implications for carcinogenesis.
Yamamoto K, Nihrane A, Aglipay J, Sironi J, Arkin S, Lipton JM, Ouchi T, Liu JM
Mol Med. 2008
PubMed ID: 18224251
Identification of p32 as a novel substrate for ATM in heart.
Kato H, Takashima S, Asano Y, Shintani Y, Yamazaki S, Seguchi O, Yamamoto H, Nakano A, Higo S, Ogai A, Minamino T, Kitakaze M, Hori M
Biochem Biophys Res Commun. 2008
PubMed ID: 18070599
Comprehensive analysis of DNA repair gene variants and risk of meningioma.
Bethke L, Murray A, Webb E, Schoemaker M, Muir K, McKinney P, Hepworth S, Dimitropoulou P, Lophatananon A, Feychting M, Lönn S, Ahlbom A, Malmer B, Henriksson R, Auvinen A, Kiuru A, Salminen T, Johansen C, Christensen HC, Kosteljanetz M, Swerdlow A, Houlston R
J Natl Cancer Inst. 2008
PubMed ID: 18270339
Atm is a negative regulator of intestinal neoplasia.
Kwong LN, Weiss KR, Haigis KM, Dove WF
Oncogene. 2008
PubMed ID: 17700532
Endoplasmic reticulum stress and unfolded protein response in Atm-deficient thymocytes and thymic lymphoma cells are attributable to oxidative stress.
Yan M, Shen J, Person MD, Kuang X, Lynn WS, Atlas D, Wong PK
Neoplasia. 2008
PubMed ID: 18283338
Detection of ATM gene mutations in young lung cancer patients: a population-based control study.
Schneider J, Illig T, Rosenberger A, Bickeböller H, Wichmann HE
Arch Med Res. 2008
PubMed ID: 18164969
Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer.
Kang B, Guo RF, Tan XH, Zhao M, Tang ZB, Lu YY
Mutat Res. 2008
PubMed ID: 17928013
ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells.
Stagni V, di Bari MG, Cursi S, Condò I, Cencioni MT, Testi R, Lerenthal Y, Cundari E, Barilà D
Blood. 2008
PubMed ID: 17932249
The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.
Tapper W, Hammond V, Gerty S, Ennis S, Simmonds P, Collins A, Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) Steering Group, Eccles D
Breast Cancer Res. 2008
PubMed ID: 19094228
Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H
BMC Genomics. 2008
PubMed ID: 18973680
Analysis of variants in DNA damage signalling genes in bladder cancer.
Choudhury A, Elliott F, Iles MM, Churchman M, Bristow RG, Bishop DT, Kiltie AE
BMC Med Genet. 2008
PubMed ID: 18638378
Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories?
Byrnes GB, Southey MC, Hopper JL
Breast Cancer Res. 2008
PubMed ID: 18557994
Association of common ATM variants with familial breast cancer in a South American population.
González-Hormazábal P, Bravo T, Blanco R, Valenzuela CY, Gómez F, Waugh E, Peralta O, Ortuzar W, Reyes JM, Jara L
BMC Cancer. 2008
PubMed ID: 18433505
DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells.
Arlander SJ, Greene BT, Innes CL, Paules RS
Cancer Res. 2008
PubMed ID: 18172300
Targeted integration of functional human ATM cDNA into genome mediated by HSV/AAV hybrid amplicon vector.
Cortés ML, Oehmig A, Saydam O, Sanford JD, Perry KF, Fraefel C, Breakefield XO
Mol Ther. 2008
PubMed ID: 17998902
The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis.
Gupta A, Guerin-Peyrou TG, Sharma GG, Park C, Agarwal M, Ganju RK, Pandita S, Choi K, Sukumar S, Pandita RK, Ludwig T, Pandita TK
Mol Cell Biol. 2008
PubMed ID: 17967868
Large genomic mutations within the ATM gene detected by MLPA, including a duplication of 41 kb from exon 4 to 20.
Cavalieri S, Funaro A, Pappi P, Migone N, Gatti RA, Brusco A
Ann Hum Genet. 2008
PubMed ID: 17910737
The spectrum of ATM missense variants and their contribution to contralateral breast cancer.
Broeks A, Braaf LM, Huseinovic A, Schmidt MK, Russell NS, van Leeuwen FE, Hogervorst FB, Van 't Veer LJ
Breast Cancer Res Treat. 2008
PubMed ID: 17393301
ATM allelic variants associated to hereditary breast cancer in 94 Chilean women: susceptibility or ethnic influences?
Tapia T, Sanchez A, Vallejos M, Alvarez C, Moraga M, Smalley S, Camus M, Alvarez M, Carvallo P
Breast Cancer Res Treat. 2008
PubMed ID: 17351744
Screening for ATM sequence alterations in African-American women diagnosed with breast cancer.
Hirsch AE, Atencio DP, Rosenstein BS
Breast Cancer Res Treat. 2008
PubMed ID: 17333338
Tel2 regulates the stability of PI3K-related protein kinases.
Takai H, Wang RC, Takai KK, Yang H, de Lange T
Cell. 2007
PubMed ID: 18160036
Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis.
Loehberg CR, Thompson T, Kastan MB, Maclean KH, Edwards DG, Kittrell FS, Medina D, Conneely OM, O'Malley BW
Cancer Res. 2007
PubMed ID: 18089834
Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression.
Li X, Lee YK, Jeng JC, Yen Y, Schultz DC, Shih HM, Ann DK
J Biol Chem. 2007
PubMed ID: 17942393
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.
Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D
Science. 2007
PubMed ID: 18006705
Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase.
Olofsson BA, Kelly CM, Kim J, Hornsby SM, Azizkhan-Clifford J
Mol Cancer Res. 2007
PubMed ID: 18171990
Ataxia-telangiectasia mutated is not required for p53 induction and apoptosis in irradiated epithelial tissues.
Gurley KE, Kemp CJ
Mol Cancer Res. 2007
PubMed ID: 18171989
ATM prevents unattended DNA double strand breaks on site and in generations to come.
Yin B, Savic V, Bassing CH
Cancer Biol Ther. 2007
PubMed ID: 18087222
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.
Sun Y, Xu Y, Roy K, Price BD
Mol Cell Biol. 2007
PubMed ID: 17923702
Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts.
Dirlam A, Spike BT, Macleod KF
Mol Cell Biol. 2007
PubMed ID: 17923680
Dynamic change of histone H2AX phosphorylation independent of ATM and DNA-PK in mouse skin in situ.
Koike M, Mashino M, Sugasawa J, Koike A
Biochem Biophys Res Commun. 2007
PubMed ID: 17923115
ATM sequence variants associate with susceptibility to non-small cell lung cancer.
Yang H, Spitz MR, Stewart DJ, Lu C, Gorlov IP, Wu X
Int J Cancer. 2007
PubMed ID: 17582598
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis.
Guo X, Deng Y, Lin Y, Cosme-Blanco W, Chan S, He H, Yuan G, Brown EJ, Chang S
EMBO J. 2007
PubMed ID: 17948054
Analysis of the genetic interactions between Cyclin A1, Atm and p53 during spermatogenesis.
Baumer N, Sandstede ML, Diederichs S, Kohler G, Readhead C, Ji P, Zhang F, Bulk E, Gromoll J, Berdel WE, Serve H, Muller-Tidow C
Asian J Androl. 2007
PubMed ID: 17968459
ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain.
Gorodetsky E, Calkins S, Ahn J, Brooks PJ
DNA Repair (Amst). 2007
PubMed ID: 17706468
A systematic evaluation of the ataxia telangiectasia mutated gene does not show an association with non-Hodgkin lymphoma.
Sipahimalani P, Spinelli JJ, MacArthur AC, Lai A, Leach SR, Janoo-Gilani RT, Palmquist DL, Connors JM, Gascoyne RD, Gallagher RP, Brooks-Wilson AR
Int J Cancer. 2007
PubMed ID: 17640065
Possession of ATM sequence variants as predictor for late normal tissue responses in breast cancer patients treated with radiotherapy.
Ho AY, Fan G, Atencio DP, Green S, Formenti SC, Haffty BG, Iyengar P, Bernstein JL, Stock RG, Cesaretti JA, Rosenstein BS
Int J Radiat Oncol Biol Phys. 2007
PubMed ID: 17517479
Two-stage case-control study of common ATM gene variants in relation to breast cancer risk.
Ye C, Dai Q, Lu W, Cai Q, Zheng Y, Shu XO, Gu K, Gao YT, Zheng W
Breast Cancer Res Treat. 2007
PubMed ID: 17431766
The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.
Reimann M, Loddenkemper C, Rudolph C, Schildhauer I, Teichmann B, Stein H, Schlegelberger B, Dörken B, Schmitt CA
Blood. 2007
PubMed ID: 17562874
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA
Cancer Cell. 2007
PubMed ID: 17936559
Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM.
Luciani MG, Campregher C, Gasche C
Carcinogenesis. 2007
PubMed ID: 17510082
Lead contamination results in late and slowly repairable DNA double-strand breaks and impacts upon the ATM-dependent signaling pathways.
Gastaldo J, Viau M, Bencokova Z, Joubert A, Charvet AM, Balosso J, Foray N
Toxicol Lett. 2007
PubMed ID: 17855027
ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia.
Joshi AD, Hegde GV, Dickinson JD, Mittal AK, Lynch JC, Eudy JD, Armitage JO, Bierman PJ, Bociek RG, Devetten MP, Vose JM, Joshi SS
Clin Cancer Res. 2007
PubMed ID: 17875758
Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells.
Ambrose M, Goldstine JV, Gatti RA
Hum Mol Genet. 2007
PubMed ID: 17606465
Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway.
McConnell JL, Gomez RJ, McCorvey LR, Law BK, Wadzinski BE
Oncogene. 2007
PubMed ID: 17384681
Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions.
Sakamoto S, Iijima K, Mochizuki D, Nakamura K, Teshigawara K, Kobayashi J, Matsuura S, Tauchi H, Komatsu K
Oncogene. 2007
PubMed ID: 17384674
Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis.
Eaton JS, Lin ZP, Sartorelli AC, Bonawitz ND, Shadel GS
J Clin Invest. 2007
PubMed ID: 17786248
MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control.
Wu Y, Xiao S, Zhu XD
Nat Struct Mol Biol. 2007
PubMed ID: 17694070
Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein.
Iwahori S, Shirata N, Kawaguchi Y, Weller SK, Sato Y, Kudoh A, Nakayama S, Isomura H, Tsurumi T
J Virol. 2007
PubMed ID: 17609267
Our cells get stressed too! Implications for human disease.
Kastan MB
Blood Cells Mol Dis. 2007
PubMed ID: 17537652
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
Denchi EL, de Lange T
Nature. 2007
PubMed ID: 17687332
Ataxia-telangiectasia: mild neurological presentation despite null ATM mutation and severe cellular phenotype.
Alterman N, Fattal-Valevski A, Moyal L, Crawford TO, Lederman HM, Ziv Y, Shiloh Y
Am J Med Genet A. 2007
PubMed ID: 17632790
Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells.
Iguchi T, Miyakawa Y, Saito K, Nakabayashi C, Nakanishi M, Saya H, Ikeda Y, Kizaki M
Int J Oncol. 2007
PubMed ID: 17611684
Characterization of an NBS1 C-terminal peptide that can inhibit ataxia telangiectasia mutated (ATM)-mediated DNA damage responses and enhance radiosensitivity.
Cariveau MJ, Tang X, Cui XL, Xu B
Mol Pharmacol. 2007
PubMed ID: 17507690
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.
Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride K, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A
Cell. 2007
PubMed ID: 17599403
Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification.
Morita K, Miyamoto T, Fujita N, Kubota Y, Ito K, Takubo K, Miyamoto K, Ninomiya K, Suzuki T, Iwasaki R, Yagi M, Takaishi H, Toyama Y, Suda T
J Exp Med. 2007
PubMed ID: 17576777
Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks.
Rao VA, Conti C, Guirouilh-Barbat J, Nakamura A, Miao ZH, Davies SL, Saccá B, Hickson ID, Bensimon A, Pommier Y
Mol Cancer Res. 2007
PubMed ID: 17634426
Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis.
Maclean KH, Kastan MB, Cleveland JL
Mol Cancer Res. 2007
PubMed ID: 17634425
[Potentials of DNA-PKcs, Ku80, and ATM in enhancing radiosensitivity of cervical carcinoma cells]
Zhuang L, Yu SY, Huang XY, Cao Y, Xiong HH
Ai Zheng. 2007
PubMed ID: 17626748
Characterization of genetic changes in MCL by interphase FISH on tissue sections.
Sander B, Wallblom A, Ekroth A, Porwit A, Kimby E
Leuk Lymphoma. 2007
PubMed ID: 17613764
The molecular causes of low ATM protein expression in breast carcinoma; promoter methylation and levels of the catalytic subunit of DNA-dependent protein kinase.
Treilleux I, Chapot B, Goddard S, Pisani P, Angèle S, Hall J
Histopathology. 2007
PubMed ID: 17593081
Impaired insulin secretion in a mouse model of ataxia telangiectasia.
Miles PD, Treuner K, Latronica M, Olefsky JM, Barlow C
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17356010
Reoxygenation following hypoxia activates DNA-damage checkpoint signaling pathways that suppress cell-cycle progression in cultured human lymphocytes.
Kim BM, Choi JY, Kim YJ, Woo HD, Chung HW
FEBS Lett. 2007
PubMed ID: 17544403
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.
Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S, Stevens C, Brennan C, Martin ES, Wiedemeyer R, Kabbarah O, Nogueira C, Histen G, Aster J, Mansour M, Duke V, Foroni L, Fielding AK, Goldstone AH, Rowe JM, Wang YA, Look AT, Stratton MR, Chin L, Futreal PA, DePinho RA
Nature. 2007
PubMed ID: 17515920
ATMIN defines an NBS1-independent pathway of ATM signalling.
Kanu N, Behrens A
EMBO J. 2007
PubMed ID: 17525732
A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.
Mu JJ, Wang Y, Luo H, Leng M, Zhang J, Yang T, Besusso D, Jung SY, Qin J
J Biol Chem. 2007
PubMed ID: 17478428
Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes.
Huang CY, Sharma GG, Walker LM, Bassing CH, Pandita TK, Sleckman BP
J Exp Med. 2007
PubMed ID: 17502661
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.
Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R
Nature. 2007
PubMed ID: 17554310
BRCA2 is required for neurogenesis and suppression of medulloblastoma.
Frappart PO, Lee Y, Lamont J, McKinnon PJ
EMBO J. 2007
PubMed ID: 17476307
ATM missense variant P1054R predisposes to prostate cancer.
Meyer A, Wilhelm B, Dörk T, Bremer M, Baumann R, Karstens JH, Machtens S
Radiother Oncol. 2007
PubMed ID: 17502119
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair.
Berkovich E, Monnat RJ, Kastan MB
Nat Cell Biol. 2007
PubMed ID: 17486112
Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents.
Haince JF, Kozlov S, Dawson VL, Dawson TM, Hendzel MJ, Lavin MF, Poirier GG
J Biol Chem. 2007
PubMed ID: 17428792
Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells.
Fernandes ND, Sun Y, Price BD
J Biol Chem. 2007
PubMed ID: 17426037
The ATM/ATR signaling effector Chk2 is targeted by Epstein-Barr virus nuclear antigen 3C to release the G2/M cell cycle block.
Choudhuri T, Verma SC, Lan K, Murakami M, Robertson ES
J Virol. 2007
PubMed ID: 17409144
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ
Science. 2007
PubMed ID: 17525332
Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest.
Yong W, Bao S, Chen H, Li D, Sánchez ER, Shou W
J Biol Chem. 2007
PubMed ID: 17376776
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis.
Difilippantonio S, Celeste A, Kruhlak MJ, Lee Y, Difilippantonio MJ, Feigenbaum L, Jackson SP, McKinnon PJ, Nussenzweig A
J Exp Med. 2007
PubMed ID: 17485521
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
Stracker TH, Morales M, Couto SS, Hussein H, Petrini JH
Nature. 2007
PubMed ID: 17429352
This article was published online in error and has been removed by the publisher.

Hum Mol Genet. 2007
PubMed ID: 17409195
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.
Kennedy RD, Chen CC, Stuckert P, Archila EM, De la Vega MA, Moreau LA, Shimamura A, D'Andrea AD
J Clin Invest. 2007
PubMed ID: 17431503
The glucocorticoid receptor is increased in Atm-/- thymocytes and in Atm-/- thymic lymphoma cells, and its nuclear translocation counteracts c-myc expression.
Yan M, Kuang X, Scofield VL, Shen J, Lynn WS, Wong PK
Steroids. 2007
PubMed ID: 17418878
Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility.
Johnson N, Fletcher O, Palles C, Rudd M, Webb E, Sellick G, dos Santos Silva I, McCormack V, Gibson L, Fraser A, Leonard A, Gilham C, Tavtigian SV, Ashworth A, Houlston R, Peto J
Hum Mol Genet. 2007
PubMed ID: 17341484
Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer.
Pylkäs K, Tommiska J, Syrjäkoski K, Kere J, Gatei M, Waddell N, Allinen M, Karppinen SM, Rapakko K, Kääriäinen H, Aittomäki K, Blomqvist C, Mustonen A, Holli K, Khanna KK, Kallioniemi OP, Nevanlinna H, Winqvist R
Carcinogenesis. 2007
PubMed ID: 17166884
Genetic variation in p53 and ATM haplotypes and risk of glioma and meningioma.
Malmer BS, Feychting M, Lönn S, Lindström S, Grönberg H, Ahlbom A, Schwartzbaum J, Auvinen A, Collatz-Christensen H, Johansen C, Kiuru A, Mudie N, Salminen T, Schoemaker MJ, Swerdlow AJ, Henriksson R
J Neurooncol. 2007
PubMed ID: 17151932
Regulation of oxidative stress responses by ataxia-telangiectasia mutated is required for T cell proliferation.
Bagley J, Singh G, Iacomini J
J Immunol. 2007
PubMed ID: 17404255
ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor alpha locus coding end breaks.
Vacchio MS, Olaru A, Livak F, Hodes RJ
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17405860
Correction of prototypic ATM splicing mutations and aberrant ATM function with antisense morpholino oligonucleotides.
Du L, Pollard JM, Gatti RA
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17389389
Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status.
Hunt CR, Pandita RK, Laszlo A, Higashikubo R, Agarwal M, Kitamura T, Gupta A, Rief N, Horikoshi N, Baskaran R, Lee JH, Löbrich M, Paull TT, Roti Roti JL, Pandita TK
Cancer Res. 2007
PubMed ID: 17409407
Ablation of Cbl-b provides protection against transplanted and spontaneous tumors.
Chiang JY, Jang IK, Hodes R, Gu H
J Clin Invest. 2007
PubMed ID: 17364027
Translocations as a mechanism for homozygous deletion of 13q14 and loss of the ATM gene in a patient with B-cell chronic lymphocytic leukemia.
Herholz H, Kern W, Schnittger S, Haferlach T, Dicker F, Haferlach C
Cancer Genet Cytogenet. 2007
PubMed ID: 17350468
Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.
Geng L, Zhang X, Zheng S, Legerski RJ
Mol Cell Biol. 2007
PubMed ID: 17242184
Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies.
Shi Y, Dodson GE, Mukhopadhyay PS, Shanware NP, Trinh AT, Tibbetts RS
J Biol Chem. 2007
PubMed ID: 17244605
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.
Chen BP, Uematsu N, Kobayashi J, Lerenthal Y, Krempler A, Yajima H, Löbrich M, Shiloh Y, Chen DJ
J Biol Chem. 2007
PubMed ID: 17189255
A novel phenotypic marker for ATM-deficient 129S6/SvEvTac-ATMtm1Awb/J mice.
Hibma JC, Neufeld DA, Halaby MJ, Yang DQ
Anat Rec (Hoboken). 2007
PubMed ID: 17525940
Distinct pattern of allelic loss and inactivation of cadherin 1 and 5 genes in mammary carcinomas arising in p53(+/-) mice.
Umesako S, Iiga S, Takahashi M, Imura K, Mori N, Hong DP, Song CW, Niwa O, Okumoto M
J Radiat Res (Tokyo). 2007
PubMed ID: 17327688
A common coding variant in CASP8 is associated with breast cancer risk.
Cox A, Dunning AM, Garcia-Closas M, Balasubramanian S, Reed MW, Pooley KA, Scollen S, Baynes C, Ponder BA, Chanock S, Lissowska J, Brinton L, Peplonska B, Southey MC, Hopper JL, McCredie MR, Giles GG, Fletcher O, Johnson N, dos Santos Silva I, Gibson L, Bojesen SE, Nordestgaard BG, Axelsson CK, Torres D, Hamann U, Justenhoven C, Brauch H, Chang-Claude J, Kropp S, Risch A, Wang-Gohrke S, Schürmann P, Bogdanova N, Dörk T, Fagerholm R, Aaltonen K, Blomqvist C, Nevanlinna H, Seal S, Renwick A, Stratton MR, Rahman N, Sangrajrang S, Hughes D, Odefrey F, Brennan P, Spurdle AB, Chenevix-Trench G, Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer, Beesley J, Mannermaa A, Hartikainen J, Kataja V, Kosma VM, Couch FJ, Olson JE, Goode EL, Broeks A, Schmidt MK, Hogervorst FB, Van't Veer LJ, Kang D, Yoo KY, Noh DY, Ahn SH, Wedrén S, Hall P, Low YL, Liu J, Milne RL, Ribas G, Gonzalez-Neira A, Benitez J, Sigurdson AJ, Stredrick DL, Alexander BH, Struewing JP, Pharoah PD, Easton DF, Breast Cancer Association Consortium
Nat Genet. 2007
PubMed ID: 17293864
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
Flores-Delgado G, Liu CW, Sposto R, Berndt N
J Proteome Res. 2007
PubMed ID: 17274640
Effect of ATM heterozygosity on heritable DNA damage in mice following paternal F0 germline irradiation.
Baulch JE, Li MW, Raabe OG
Mutat Res. 2007
PubMed ID: 17161850
ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes.
Matei IR, Gladdy RA, Nutter LM, Canty A, Guidos CJ, Danska JS
Blood. 2007
PubMed ID: 17077325
ATM regulates ionizing radiation-induced disruption of HDAC1:PP1:Rb complexes.
Guo C, Mi J, Brautigan DL, Larner JM
Cell Signal. 2007
PubMed ID: 17008050
DDB1 is essential for genomic stability in developing epidermis.
Cang Y, Zhang J, Nicholas SA, Kim AL, Zhou P, Goff SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17301228
A role for Xrcc2 in the early stages of mouse development.
Adam J, Deans B, Thacker J
DNA Repair (Amst). 2007
PubMed ID: 17116431
Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes.
Tanaka T, Kajstura M, Halicka HD, Traganos F, Darzynkiewicz Z
Cell Prolif. 2007
PubMed ID: 17227291
ATM gene mutations in former uranium miners of SDAG Wismut: a pilot study.
Schneider J, Philipp M, Yamini P, Dörk T, Woitowitz HJ
Oncol Rep. 2007
PubMed ID: 17203191
Regulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A.
Jang YJ, Ji JH, Choi YC, Ryu CJ, Ko SY
J Biol Chem. 2007
PubMed ID: 17121863
HIV-1 Vpr induces ATM-dependent cellular signal with enhanced homologous recombination.
Nakai-Murakami C, Shimura M, Kinomoto M, Takizawa Y, Tokunaga K, Taguchi T, Hoshino S, Miyagawa K, Sata T, Kurumizaka H, Yuo A, Ishizaka Y
Oncogene. 2007
PubMed ID: 16983346
Effect of ATM, CHEK2 and ERBB2 TAGSNPs and haplotypes on endometrial cancer risk.
Einarsdóttir K, Humphreys K, Bonnard C, Li Y, Li Y, Chia KS, Liu ET, Hall P, Liu J, Wedrén S
Hum Mol Genet. 2007
PubMed ID: 17164260
Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence.
Edvardsen H, Tefre T, Jansen L, Vu P, Haffty BG, Fosså SD, Kristensen VN, Børresen-Dale AL
Radiat Oncol. 2007
PubMed ID: 17623063
ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke.
Tanaka T, Huang X, Jorgensen E, Gietl D, Traganos F, Darzynkiewicz Z, Albino AP
BMC Cell Biol. 2007
PubMed ID: 17594478
RNA structure is a key regulatory element in pathological ATM and CFTR pseudoexon inclusion events.
Buratti E, Dhir A, Lewandowska MA, Baralle FE
Nucleic Acids Res. 2007
PubMed ID: 17580311
Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition.
Aguilar-Quesada R, Muñoz-Gámez JA, Martín-Oliva D, Peralta A, Valenzuela MT, Matínez-Romero R, Quiles-Pérez R, Menissier-de Murcia J, de Murcia G, de Almodóvar MR, Oliver FJ
BMC Mol Biol. 2007
PubMed ID: 17459151
Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk.
Baynes C, Healey CS, Pooley KA, Scollen S, Luben RN, Thompson DJ, Pharoah PD, Easton DF, Ponder BA, Dunning AM, SEARCH breast cancer study
Breast Cancer Res. 2007
PubMed ID: 17428325
Identification of women with an increased risk of developing radiation-induced breast cancer: a case only study.
Broeks A, Braaf LM, Huseinovic A, Nooijen A, Urbanus J, Hogervorst FB, Schmidt MK, Klijn JG, Russell NS, Van Leeuwen FE, Van 't Veer LJ
Breast Cancer Res. 2007
PubMed ID: 17428320
Antioxidants suppress lymphoma and increase longevity in Atm-deficient mice.
Reliene R, Schiestl RH
J Nutr. 2007
PubMed ID: 17182831
Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.
Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, Ohmura M, Naka K, Azuma M, Miyamoto K, Hosokawa K, Ikeda Y, Mak TW, Suda T, Hirao A
J Immunol. 2007
PubMed ID: 17182545
Ataxia-telangiectasia mutated expression is associated with tobacco smoke exposure in esophageal cancer tissues and benzo[a]pyrene diol epoxide in cell lines.
Jiang Y, Liang ZD, Wu TT, Cao L, Zhang H, Xu XC
Int J Cancer. 2007
PubMed ID: 17019709
Premeiotic germ cell defect in seminiferous tubules of Atm-null testis.
Takubo K, Hirao A, Ohmura M, Azuma M, Arai F, Nagamatsu G, Suda T
Biochem Biophys Res Commun. 2006
PubMed ID: 17097049
Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
Shreeram S, Hee WK, Demidov ON, Kek C, Yamaguchi H, Fornace AJ, Anderson CW, Appella E, Bulavin DV
J Exp Med. 2006
PubMed ID: 17158963
Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation.
Nyati MK, Feng FY, Maheshwari D, Varambally S, Zielske SP, Ahsan A, Chun PY, Arora VA, Davis MA, Jung M, Ljungman M, Canman CE, Chinnaiyan AM, Lawrence TS
Cancer Res. 2006
PubMed ID: 17178844
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling.
Stiff T, Walker SA, Cerosaletti K, Goodarzi AA, Petermann E, Concannon P, O'Driscoll M, Jeggo PA
EMBO J. 2006
PubMed ID: 17124492
Ataxia-telangiectasia-mutated-dependent activation of Ku in human fibroblasts exposed to hydrogen peroxide.
Lee JH, Kim KH, Morio T, Kim H
Ann N Y Acad Sci. 2006
PubMed ID: 17341604
TGFbeta1-induced activation of ATM and p53 mediates apoptosis in a Smad7-dependent manner.
Zhang S, Ekman M, Thakur N, Bu S, Davoodpour P, Grimsby S, Tagami S, Heldin CH, Landström M
Cell Cycle. 2006
PubMed ID: 17172861
Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint.
Bruno T, De Nicola F, Iezzi S, Lecis D, D'Angelo C, Di Padova M, Corbi N, Dimiziani L, Zannini L, Jekimovs C, Scarsella M, Porrello A, Chersi A, Crescenzi M, Leonetti C, Khanna KK, Soddu S, Floridi A, Passananti C, Delia D, Fanciulli M
Cancer Cell. 2006
PubMed ID: 17157788
HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT.
Andersen JL, DeHart JL, Zimmerman ES, Ardon O, Kim B, Jacquot G, Benichou S, Planelles V
PLoS Pathog. 2006
PubMed ID: 17140287
Characterization of the breast cancer associated ATM 7271T>G (V2424G) mutation by gene expression profiling.
Waddell N, Jonnalagadda J, Marsh A, Grist S, Jenkins M, Hobson K, Taylor M, Lindeman GJ, Tavtigian SV, Suthers G, Goldgar D, Oefner PJ, kConFab Investigators, Taylor D, Grimmond S, Khanna KK, Chenevix-Trench G
Genes Chromosomes Cancer. 2006
PubMed ID: 17001622
ATM is activated by mitotic stress and suppresses centrosome amplification in primary but not in tumor cells.
Shen K, Wang Y, Brooks SC, Raz A, Wang YA
J Cell Biochem. 2006
PubMed ID: 16775842
Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages.
Liebe B, Petukhova G, Barchi M, Bellani M, Braselmann H, Nakano T, Pandita TK, Jasin M, Fornace A, Meistrich ML, Baarends WM, Schimenti J, de Lange T, Keeney S, Camerini-Otero RD, Scherthan H
Exp Cell Res. 2006
PubMed ID: 17010969
Developmental cell death in the liver and newborn lethality of Ku86 deficient mice suppressed by antioxidant N-acetyl-cysteine.
Reliene R, Goad ME, Schiestl RH
DNA Repair (Amst). 2006
PubMed ID: 16916625
Phosphorylation of histone H2AX on Ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes.
Tanaka T, Halicka HD, Traganos F, Darzynkiewicz Z
Cell Cycle. 2006
PubMed ID: 17106266
ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome.
Schneider JG, Finck BN, Ren J, Standley KN, Takagi M, Maclean KH, Bernal-Mizrachi C, Muslin AJ, Kastan MB, Semenkovich CF
Cell Metab. 2006
PubMed ID: 17084711
Histopathological features of breast cancer in carriers of ATM gene variants.
Balleine RL, Murali R, Bilous AM, Farshid G, Waring P, Provan P, Byth K, Thorne H, kConFab Investigators, Kirk JA
Histopathology. 2006
PubMed ID: 17064299
Population-based estimates of breast cancer risks associated with ATM gene variants c.7271T>G and c.1066-6T>G (IVS10-6T>G) from the Breast Cancer Family Registry.
Bernstein JL, Teraoka S, Southey MC, Jenkins MA, Andrulis IL, Knight JA, John EM, Lapinski R, Wolitzer AL, Whittemore AS, West D, Seminara D, Olson ER, Spurdle AB, Chenevix-Trench G, Giles GG, Hopper JL, Concannon P
Hum Mutat. 2006
PubMed ID: 16958054
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y
J Biol Chem. 2006
PubMed ID: 16905549
Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR.
Dellaire G, Ching RW, Ahmed K, Jalali F, Tse KC, Bristow RG, Bazett-Jones DP
J Cell Biol. 2006
PubMed ID: 17030982
Comprehensive analysis of differential gene expression profiles on D-galactosamine-induced acute mouse liver injury and regeneration.
Chung H, Kim HJ, Jang KS, Kim M, Yang J, Kang KS, Kim HL, Yoon BI, Lee MO, Lee BH, Kim JH, Lee YS, Kong G
Toxicology. 2006
PubMed ID: 16962228
ATM activation is accompanied with earlier stages of prostate tumorigenesis.
Fan C, Quan R, Feng X, Gillis A, He L, Matsumoto ED, Salama S, Cutz JC, Kapoor A, Tang D
Biochim Biophys Acta. 2006
PubMed ID: 16997395
ATM mutations in Italian families with ataxia telangiectasia include two distinct large genomic deletions.
Cavalieri S, Funaro A, Porcedda P, Turinetto V, Migone N, Gatti RA, Brusco A
Hum Mutat. 2006
PubMed ID: 16941484
ATM and breast cancer susceptibility.
Ahmed M, Rahman N
Oncogene. 2006
PubMed ID: 16998505
Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant.
Gueven N, Luff J, Peng C, Hosokawa K, Bottle SE, Lavin MF
Free Radic Biol Med. 2006
PubMed ID: 16934683
The involvement of ataxia-telangiectasia mutated protein activation in nucleotide excision repair-facilitated cell survival with cisplatin treatment.
Colton SL, Xu XS, Wang YA, Wang G
J Biol Chem. 2006
PubMed ID: 16849332
Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo.
Pellegrini M, Celeste A, Difilippantonio S, Guo R, Wang W, Feigenbaum L, Nussenzweig A
Nature. 2006
PubMed ID: 16906133
Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression.
Zhang J, Lahti JM, Bruce A, He L, Parihar K, Fan C, Grenet J, Liu L, Kidd VJ, Cormier S, Tang D
Oncogene. 2006
PubMed ID: 16636671
Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells.
Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R, Bachs O, Agell N
Cancer Res. 2006
PubMed ID: 16951182
Wip1 phosphatase modulates ATM-dependent signaling pathways.
Shreeram S, Demidov ON, Hee WK, Yamaguchi H, Onishi N, Kek C, Timofeev ON, Dudgeon C, Fornace AJ, Anderson CW, Minami Y, Appella E, Bulavin DV
Mol Cell. 2006
PubMed ID: 16949371
Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance.
Ho GP, Margossian S, Taniguchi T, D'Andrea AD
Mol Cell Biol. 2006
PubMed ID: 16943440
Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.
Pereg Y, Lam S, Teunisse A, Biton S, Meulmeester E, Mittelman L, Buscemi G, Okamoto K, Taya Y, Shiloh Y, Jochemsen AG
Mol Cell Biol. 2006
PubMed ID: 16943424
ATR dependent activation of Chk2.
Wang XQ, Redpath JL, Fan ST, Stanbridge EJ
J Cell Physiol. 2006
PubMed ID: 16741947
CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM.
Zhang L, Tie Y, Tian C, Xing G, Song Y, Zhu Y, Sun Z, He F
Cell Signal. 2006
PubMed ID: 16325375
ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage.
Dornan D, Shimizu H, Mah A, Dudhela T, Eby M, O'rourke K, Seshagiri S, Dixit VM
Science. 2006
PubMed ID: 16931761
ATM controls c-Myc and DNA synthesis during postnatal thymocyte development through regulation of redox state.
Yan M, Zhu C, Liu N, Jiang Y, Scofield VL, Riggs PK, Qiang W, Lynn WS, Wong PK
Free Radic Biol Med. 2006
PubMed ID: 16863997
Effect of the reduction of superoxide dismutase 1 and 2 or treatment with alpha-tocopherol on tumorigenesis in Atm-deficient mice.
Erker L, Schubert R, Elchuri S, Huang TT, Tarin D, Mueller K, Zielen S, Epstein CJ, Wynshaw-Boris A
Free Radic Biol Med. 2006
PubMed ID: 16863992
Involvement of novel autophosphorylation sites in ATM activation.
Kozlov SV, Graham ME, Peng C, Chen P, Robinson PJ, Lavin MF
EMBO J. 2006
PubMed ID: 16858402
Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples.
Andreassen CN, Alsner J, Overgaard M, Sørensen FB, Overgaard J
Int J Radiat Biol. 2006
PubMed ID: 16966185
BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer.
Rai R, Dai H, Multani AS, Li K, Chin K, Gray J, Lahad JP, Liang J, Mills GB, Meric-Bernstam F, Lin SY
Cancer Cell. 2006
PubMed ID: 16872911
ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles.
Renwick A, Thompson D, Seal S, Kelly P, Chagtai T, Ahmed M, North B, Jayatilake H, Barfoot R, Spanova K, McGuffog L, Evans DG, Eccles D, Breast Cancer Susceptibility Collaboration (UK), Easton DF, Stratton MR, Rahman N
Nat Genet. 2006
PubMed ID: 16832357
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.
Bredemeyer AL, Sharma GG, Huang CY, Helmink BA, Walker LM, Khor KC, Nuskey B, Sullivan KE, Pandita TK, Bassing CH, Sleckman BP
Nature. 2006
PubMed ID: 16799570
Variants in the ATM-BRCA2-CHEK2 axis predispose to chronic lymphocytic leukemia.
Rudd MF, Sellick GS, Webb EL, Catovsky D, Houlston RS
Blood. 2006
PubMed ID: 16574953
Antioxidant N-acetyl cysteine reduces incidence and multiplicity of lymphoma in Atm deficient mice.
Reliene R, Schiestl RH
DNA Repair (Amst). 2006
PubMed ID: 16781197
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.
Oliver AW, Paul A, Boxall KJ, Barrie SE, Aherne GW, Garrett MD, Mittnacht S, Pearl LH
EMBO J. 2006
PubMed ID: 16794575
ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin.
Kobayashi M, Ono H, Mihara K, Tauchi H, Komatsu K, Shibata T, Shimizu H, Uchida K, Yamamoto K
Genes Cells. 2006
PubMed ID: 16824197
Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex.
Adams KE, Medhurst AL, Dart DA, Lakin ND
Oncogene. 2006
PubMed ID: 16474843
Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development.
Orii KE, Lee Y, Kondo N, McKinnon PJ
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16777961
Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells.
Biton S, Dar I, Mittelman L, Pereg Y, Barzilai A, Shiloh Y
J Biol Chem. 2006
PubMed ID: 16627474
Atm-deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesis.
Rasheed N, Wang X, Niu QT, Yeh J, Li B
Hum Mol Genet. 2006
PubMed ID: 16644862
Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity.
Roy K, Wang L, Makrigiorgos GM, Price BD
Biochem Biophys Res Commun. 2006
PubMed ID: 16631604
The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.
Jiang X, Sun Y, Chen S, Roy K, Price BD
J Biol Chem. 2006
PubMed ID: 16603769
Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation.
Irarrazabal CE, Burg MB, Ward SG, Ferraris JD
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16728507
ATM polymorphism IVS62+60G>A is not associated with disease aggressiveness in prostate cancer.
Browning RE, Li H, Shinohara ET, Cai Q, Chen H, Courtney R, Cao C, Zheng W, Lu B
Urology. 2006
PubMed ID: 16765197
p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress.
Eymin B, Claverie P, Salon C, Leduc C, Col E, Brambilla E, Khochbin S, Gazzeri S
Mol Cell Biol. 2006
PubMed ID: 16705183
The ATM missense mutation p.Ser49Cys (c.146C>G) and the risk of breast cancer.
Stredrick DL, Garcia-Closas M, Pineda MA, Bhatti P, Alexander BH, Doody MM, Lissowska J, Peplonska B, Brinton LA, Chanock SJ, Struewing JP, Sigurdson AJ
Hum Mutat. 2006
PubMed ID: 16652348
The complexity of p53 stabilization and activation.
Lavin MF, Gueven N
Cell Death Differ. 2006
PubMed ID: 16601750
ATM haplotypes and breast cancer risk in Jewish high-risk women.
Koren M, Kimmel G, Ben-Asher E, Gal I, Papa MZ, Beckmann JS, Lancet D, Shamir R, Friedman E
Br J Cancer. 2006
PubMed ID: 16622469
ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.
Cao L, Kim S, Xiao C, Wang RH, Coumoul X, Wang X, Li WM, Xu XL, De Soto JA, Takai H, Mai S, Elledge SJ, Motoyama N, Deng CX
EMBO J. 2006
PubMed ID: 16675955
Lack of Rb and p53 delays cerebellar development and predisposes to large cell anaplastic medulloblastoma through amplification of N-Myc and Ptch2.
Shakhova O, Leung C, van Montfort E, Berns A, Marino S
Cancer Res. 2006
PubMed ID: 16707443
p53 stabilization and transactivation by a von Hippel-Lindau protein.
Roe JS, Kim H, Lee SM, Kim ST, Cho EJ, Youn HD
Mol Cell. 2006
PubMed ID: 16678111
p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc.
Gladdy RA, Nutter LM, Kunath T, Danska JS, Guidos CJ
Mol Cancer Res. 2006
PubMed ID: 16687486
SUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cells.
Nguyen HV, Chen JL, Zhong J, Kim KJ, Crandall ED, Borok Z, Chen Y, Ann DK
Am J Pathol. 2006
PubMed ID: 16651613
Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer.
Damaraju S, Murray D, Dufour J, Carandang D, Myrehaug S, Fallone G, Field C, Greiner R, Hanson J, Cass CE, Parliament M
Clin Cancer Res. 2006
PubMed ID: 16638864
ATM alterations in childhood non-Hodgkin lymphoma.
Gumy-Pause F, Wacker P, Maillet P, Betts DR, Sappino AP
Cancer Genet Cytogenet. 2006
PubMed ID: 16631465
Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.
Bahassi el M, Myer DL, McKenney RJ, Hennigan RF, Stambrook PJ
Mutat Res. 2006
PubMed ID: 16481012
Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer.
Li D, Frazier M, Evans DB, Hess KR, Crane CH, Jiao L, Abbruzzese JL
J Clin Oncol. 2006
PubMed ID: 16520463
Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with ICF syndrome without downstream kinase activity.
Goldstine JV, Nahas S, Gamo K, Gartler SM, Hansen RS, Roelfsema JH, Gatti RA, Marahrens Y
DNA Repair (Amst). 2006
PubMed ID: 16426903
Rapid activation of ATR by ionizing radiation requires ATM and Mre11.
Myers JS, Cortez D
J Biol Chem. 2006
PubMed ID: 16431910
2-deoxy-D-glucose reduces the level of constitutive activation of ATM and phosphorylation of histone H2AX.
Tanaka T, Kurose A, Halicka HD, Traganos F, Darzynkiewicz Z
Cell Cycle. 2006
PubMed ID: 16628006
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Oncogenes and the DNA damage response: Myc and E2F1 engage the ATM signaling pathway to activate p53 and induce apoptosis.
Hong S, Pusapati RV, Powers JT, Johnson DG
Cell Cycle. 2006
PubMed ID: 16582589
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.
Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y, Suda T
Nat Med. 2006
PubMed ID: 16565722
DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis.
Xu Y
Nat Rev Immunol. 2006
PubMed ID: 16498454
Genetic polymorphisms of ataxia telangiectasia mutated affect lung cancer risk.
Kim JH, Kim H, Lee KY, Choe KH, Ryu JS, Yoon HI, Sung SW, Yoo KY, Hong YC
Hum Mol Genet. 2006
PubMed ID: 16497724
Atm-haploinsufficiency enhances susceptibility to carcinogen-induced mammary tumors.
Lu S, Shen K, Wang Y, Santner SJ, Chen J, Brooks SC, Wang YA
Carcinogenesis. 2006
PubMed ID: 16400190
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
Nature. 2006
PubMed ID: 16554811
Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation.
Wu X, Shell SM, Yang Z, Zou Y
Cancer Res. 2006
PubMed ID: 16540648
Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue.
Rashi-Elkeles S, Elkon R, Weizman N, Linhart C, Amariglio N, Sternberg G, Rechavi G, Barzilai A, Shamir R, Shiloh Y
Oncogene. 2006
PubMed ID: 16314843
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.
Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC
Nature. 2006
PubMed ID: 16400328
Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer.
Grabsch H, Dattani M, Barker L, Maughan N, Maude K, Hansen O, Gabbert HE, Quirke P, Mueller W
Clin Cancer Res. 2006
PubMed ID: 16533773
Active role for nibrin in the kinetics of atm activation.
Cerosaletti K, Wright J, Concannon P
Mol Cell Biol. 2006
PubMed ID: 16478990
Ataxia-telangiectasia-mutated (ATM) protein can enhance human immunodeficiency virus type 1 replication by stimulating Rev function.
Ariumi Y, Trono D
J Virol. 2006
PubMed ID: 16474151
Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1.
Shin YC, Nakamura H, Liang X, Feng P, Chang H, Kowalik TF, Jung JU
J Virol. 2006
PubMed ID: 16474133
ATM sequence variants and risk of radiation-induced subcutaneous fibrosis after postmastectomy radiotherapy.
Andreassen CN, Overgaard J, Alsner J, Overgaard M, Herskind C, Cesaretti JA, Atencio DP, Green S, Formenti SC, Stock RG, Rosenstein BS
Int J Radiat Oncol Biol Phys. 2006
PubMed ID: 16338099
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli.
Wu ZH, Shi Y, Tibbetts RS, Miyamoto S
Science. 2006
PubMed ID: 16497931
ATM regulates ATR chromatin loading in response to DNA double-strand breaks.
Cuadrado M, Martinez-Pastor B, Murga M, Toledo LI, Gutierrez-Martinez P, Lopez E, Fernandez-Capetillo O
J Exp Med. 2006
PubMed ID: 16461339
Mutation analysis of the ATM gene in two Chinese patients with ataxia telangiectasia.
Jiang H, Tang B, Xia K, Hu Z, Shen L, Tang J, Zhao G, Zhang Y, Cai F, Pan Q, Long Z, Wang G, Dai H
J Neurol Sci. 2006
PubMed ID: 16380133
Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres.
Feldser D, Strong MA, Greider CW
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16467146
ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis.
Tanaka T, Kurose A, Huang X, Dai W, Darzynkiewicz Z
Cell Prolif. 2006
PubMed ID: 16426422
ATM gene expression is associated with differentiation and angiogenesis in infiltrating breast carcinomas.
Cuatrecasas M, Santamaria G, Velasco M, Camacho E, Hernandez L, Sanchez M, Orrit C, Murcia C, Cardesa A, Campo E, Fernandez PL
Histol Histopathol. 2006
PubMed ID: 16329039
ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.
Pusapati RV, Rounbehler RJ, Hong S, Powers JT, Yan M, Kiguchi K, McArthur MJ, Wong PK, Johnson DG
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16432227
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.
Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J
Mol Cell. 2006
PubMed ID: 16427009
DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.
Dodson GE, Tibbetts RS
J Biol Chem. 2006
PubMed ID: 16293623
Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study.
Einarsdóttir K, Rosenberg LU, Humphreys K, Bonnard C, Palmgren J, Li Y, Li Y, Chia KS, Liu ET, Hall P, Liu J, Wedrén S
Breast Cancer Res. 2006
PubMed ID: 17132159
ATM variants and cancer risk in breast cancer patients from Southern Finland.
Tommiska J, Jansen L, Kilpivaara O, Edvardsen H, Kristensen V, Tamminen A, Aittomäki K, Blomqvist C, Børresen-Dale AL, Nevanlinna H
BMC Cancer. 2006
PubMed ID: 16914028
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.
Stetson DB, Medzhitov R
Immunity. 2006
PubMed ID: 16413926
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks.
Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP
Nat Cell Biol. 2006
PubMed ID: 16327781
Increased transferrin receptor expression following 11q23 deletion as a mechanism of malignant progression in chronic lymphocytic leukemia.
Shackelford RE, Bhalodia AR, Cotelingam JD, Veillon DM, Lowery-Nordberg M
Med Hypotheses. 2006
PubMed ID: 16326028
ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity.
Oricchio E, Saladino C, Iacovelli S, Soddu S, Cundari E
Cell Cycle. 2006
PubMed ID: 16319535
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.
Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH
Genes Dev. 2005
PubMed ID: 16357220
Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo.
Shi Y, Dodson GE, Shaikh S, Rundell K, Tibbetts RS
J Biol Chem. 2005
PubMed ID: 16221684
Inhibition of TFII-I-dependent cell cycle regulation by p53.
Desgranges ZP, Ahn J, Lazebnik MB, Ashworth T, Lee C, Pestell RC, Rosenberg N, Prives C, Roy AL
Mol Cell Biol. 2005
PubMed ID: 16314517
ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes.
Liu N, Stoica G, Yan M, Scofield VL, Qiang W, Lynn WS, Wong PK
Lab Invest. 2005
PubMed ID: 16189515
Inhibition of Atm and/or Atr disrupts gene silencing on the inactive X chromosome.
Ouyang Y, Salstrom J, Diaz-Perez S, Nahas S, Matsuno Y, Dawson D, Teitell MA, Horvath S, Riggs AD, Gatti RA, Marahrens Y
Biochem Biophys Res Commun. 2005
PubMed ID: 16213462
ATM gene founder haplotypes and associated mutations in Polish families with ataxia-telangiectasia.
Mitui M, Bernatowska E, Pietrucha B, Piotrowska-Jastrzebska J, Eng L, Nahas S, Teraoka S, Sholty G, Purayidom A, Concannon P, Gatti RA
Ann Hum Genet. 2005
PubMed ID: 16266405
Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis.
Kurose A, Tanaka T, Huang X, Halicka HD, Traganos F, Dai W, Darzynkiewicz Z
Cytometry A. 2005
PubMed ID: 16184611
Relation between genetic variants of the ataxia telangiectasia-mutated (ATM) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia.
Meier M, den Boer ML, Hall AG, Irving JA, Passier M, Minto L, van Wering ER, Janka-Schaub GE, Pieters R
Leukemia. 2005
PubMed ID: 16167060
Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL.
Austen B, Powell JE, Alvi A, Edwards I, Hooper L, Starczynski J, Taylor AM, Fegan C, Moss P, Stankovic T
Blood. 2005
PubMed ID: 16014569
Impaired hepatocyte survival and liver regeneration in Atm-deficient mice.
Lu S, Shen KC, Wang Y, Brooks SC, Wang YA
Hum Mol Genet. 2005
PubMed ID: 16141284
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.
Chen L, Gilkes DM, Pan Y, Lane WS, Chen J
EMBO J. 2005
PubMed ID: 16163388
ATM and p21 cooperate to suppress aneuploidy and subsequent tumor development.
Shen KC, Heng H, Wang Y, Lu S, Liu G, Deng CX, Brooks SC, Wang YA
Cancer Res. 2005
PubMed ID: 16204044
Atm heterozygosity cooperates with loss of Brca1 to increase the severity of mammary gland cancer and reduce ductal branching.
Bowen TJ, Yakushiji H, Montagna C, Jain S, Ried T, Wynshaw-Boris A
Cancer Res. 2005
PubMed ID: 16204043
Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.
Ziv S, Brenner O, Amariglio N, Smorodinsky NI, Galron R, Carrion DV, Zhang W, Sharma GG, Pandita RK, Agarwal M, Elkon R, Katzin N, Bar-Am I, Pandita TK, Kucherlapati R, Rechavi G, Shiloh Y, Barzilai A
Hum Mol Genet. 2005
PubMed ID: 16150740
Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation.
Hishiya A, Ito M, Aburatani H, Motoyama N, Ikeda K, Watanabe K
Bone. 2005
PubMed ID: 16027059
Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas.
Winrow CJ, Pankratz DG, Vibat CR, Bowen TJ, Callahan MA, Warren AJ, Hilbush BS, Wynshaw-Boris A, Hasel KW, Weaver Z, Lockhart DJ, Barlow C
Hum Mol Genet. 2005
PubMed ID: 16087685
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.
Sun Y, Jiang X, Chen S, Fernandes N, Price BD
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16141325
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1.
Kaygun H, Marzluff WF
Nat Struct Mol Biol. 2005
PubMed ID: 16086026
ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation.
Meulmeester E, Pereg Y, Shiloh Y, Jochemsen AG
Cell Cycle. 2005
PubMed ID: 16082221
Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP/OREBP.
Zhang Z, Ferraris JD, Irarrazabal CE, Dmitrieva NI, Park JH, Burg MB
Am J Physiol Renal Physiol. 2005
PubMed ID: 15840767
Proapoptotic BID is an ATM effector in the DNA-damage response.
Kamer I, Sarig R, Zaltsman Y, Niv H, Oberkovitz G, Regev L, Haimovich G, Lerenthal Y, Marcellus RC, Gross A
Cell. 2005
PubMed ID: 16122426
ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress.
Pauklin S, Kristjuhan A, Maimets T, Jaks V
Biochem Biophys Res Commun. 2005
PubMed ID: 16004968
Activation of ataxia telangiectasia-mutated DNA damage checkpoint signal transduction elicited by herpes simplex virus infection.
Shirata N, Kudoh A, Daikoku T, Tatsumi Y, Fujita M, Kiyono T, Sugaya Y, Isomura H, Ishizaki K, Tsurumi T
J Biol Chem. 2005
PubMed ID: 15964848
Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage.
Barchi M, Mahadevaiah S, Di Giacomo M, Baudat F, de Rooij DG, Burgoyne PS, Jasin M, Keeney S
Mol Cell Biol. 2005
PubMed ID: 16055729
ATM polymorphism and hereditary nonpolyposis colorectal cancer (HNPCC) age of onset (United States).
Jones JS, Gu X, Lynch PM, Rodriguez-Bigas M, Amos CI, Frazier ML
Cancer Causes Control. 2005
PubMed ID: 16049814
ATM expression in rectal cancers with or without preoperative radiotherapy.
Arlehag L, Adell G, Knutsen A, Thorstenson S, Sun XF
Oncol Rep. 2005
PubMed ID: 16012708
SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes.
Bellani MA, Romanienko PJ, Cairatti DA, Camerini-Otero RD
J Cell Sci. 2005
PubMed ID: 15998665
Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.
Young DB, Jonnalagadda J, Gatei M, Jans DA, Meyn S, Khanna KK
J Biol Chem. 2005
PubMed ID: 15929992
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.
Celli GB, de Lange T
Nat Cell Biol. 2005
PubMed ID: 15968270
Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation.
Qi L, Strong MA, Karim BO, Huso DL, Greider CW
Nat Cell Biol. 2005
PubMed ID: 15965466
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.
You Z, Chahwan C, Bailis J, Hunter T, Russell P
Mol Cell Biol. 2005
PubMed ID: 15964794
Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice.
Wu D, Yang H, Xiang W, Zhou L, Shi M, Julies G, Laplante JM, Ballard BR, Guo Z
J Lipid Res. 2005
PubMed ID: 15863839
Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis.
Truman JP, Gueven N, Lavin M, Leibel S, Kolesnick R, Fuks Z, Haimovitz-Friedman A
J Biol Chem. 2005
PubMed ID: 15837784
Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor.
Erker L, Schubert R, Yakushiji H, Barlow C, Larson D, Mitchell JB, Wynshaw-Boris A
Hum Mol Genet. 2005
PubMed ID: 15888486
Cancer risks and mortality in heterozygous ATM mutation carriers.
Thompson D, Duedal S, Kirner J, McGuffog L, Last J, Reiman A, Byrd P, Taylor M, Easton DF
J Natl Cancer Inst. 2005
PubMed ID: 15928302
Involvement of human MOF in ATM function.
Gupta A, Sharma GG, Young CS, Agarwal M, Smith ER, Paull TT, Lucchesi JC, Khanna KK, Ludwig T, Pandita TK
Mol Cell Biol. 2005
PubMed ID: 15923642
ATM mutations, haplotype analysis, and immunological status of Russian patients with ataxia telangiectasia.
Birrell GW, Kneebone K, Nefedov M, Nefedova E, Jartsev MN, Mitsui M, Gatti RA, Lavin MF
Hum Mutat. 2005
PubMed ID: 15880721
Two ATM variants and breast cancer risk.
Thompson D, Antoniou AC, Jenkins M, Marsh A, Chen X, Wayne T, Tesoriero A, Milne R, Spurdle A, Thorstenson Y, Southey M, Giles GG, Khanna KK, Sambrook J, Oefner P, Goldgar D, Hopper JL, Easton D, Chenevix-Trench G, KConFab Investigators
Hum Mutat. 2005
PubMed ID: 15880680
ATM activation in normal human tissues and testicular cancer.
Bartkova J, Bakkenist CJ, Rajpert-De Meyts E, Skakkebaek NE, Sehested M, Lukas J, Kastan MB, Bartek J
Cell Cycle. 2005
PubMed ID: 15846060
ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.
Bhoumik A, Takahashi S, Breitweiser W, Shiloh Y, Jones N, Ronai Z
Mol Cell. 2005
PubMed ID: 15916964
The ATM/p53/p21 pathway influences cell fate decision between apoptosis and senescence in reoxygenated hematopoietic progenitor cells.
Zhang X, Li J, Sejas DP, Pang Q
J Biol Chem. 2005
PubMed ID: 15753076
ATM regulates target switching to escalating doses of radiation in the intestines.
Ch'ang HJ, Maj JG, Paris F, Xing HR, Zhang J, Truman JP, Cardon-Cardo C, Haimovitz-Friedman A, Kolesnick R, Fuks Z
Nat Med. 2005
PubMed ID: 15864314
Rheb binds and regulates the mTOR kinase.
Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J
Curr Biol. 2005
PubMed ID: 15854902
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.
Lee JH, Paull TT
Science. 2005
PubMed ID: 15790808
DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.
Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD
J Biol Chem. 2005
PubMed ID: 15713674
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.
Pereg Y, Shkedy D, de Graaf P, Meulmeester E, Edelson-Averbukh M, Salek M, Biton S, Teunisse AF, Lehmann WD, Jochemsen AG, Shiloh Y
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15788536
TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer.
Andreassen CN, Alsner J, Overgaard J, Herskind C, Haviland J, Owen R, Homewood J, Bliss J, Yarnold J
Radiother Oncol. 2005
PubMed ID: 15878096
Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk.
Lee KM, Choi JY, Park SK, Chung HW, Ahn B, Yoo KY, Han W, Noh DY, Ahn SH, Kim H, Wei Q, Kang D
Cancer Epidemiol Biomarkers Prev. 2005
PubMed ID: 15824150
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.
Falck J, Coates J, Jackson SP
Nature. 2005
PubMed ID: 15758953
Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism.
Yang Y, Herrup K
J Neurosci. 2005
PubMed ID: 15758161
Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment.
Kudoh A, Fujita M, Zhang L, Shirata N, Daikoku T, Sugaya Y, Isomura H, Nishiyama Y, Tsurumi T
J Biol Chem. 2005
PubMed ID: 15611093
The alkylating carcinogen N-methyl-N'-nitro-N-nitrosoguanidine activates the plasminogen activator inhibitor-1 gene through sequential phosphorylation of p53 by ATM and ATR kinases.
Vidal B, Parra M, Jardí M, Saito S, Appella E, Muñoz-Cánoves P
Thromb Haemost. 2005
PubMed ID: 15735814
Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.
Viniegra JG, Martínez N, Modirassari P, Losa JH, Parada Cobo C, Lobo VJ, Luquero CI, Alvarez-Vallina L, Ramón y Cajal S, Rojas JM, Sánchez-Prieto R
J Biol Chem. 2005
PubMed ID: 15546863
Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks.
Ismail IH, Nyström S, Nygren J, Hammarsten O
J Biol Chem. 2005
PubMed ID: 15546858
Combined haploinsufficiency for ATM and RAD9 as a factor in cell transformation, apoptosis, and DNA lesion repair dynamics.
Smilenov LB, Lieberman HB, Mitchell SA, Baker RA, Hopkins KM, Hall EJ
Cancer Res. 2005
PubMed ID: 15705893
Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors.
Wang H, Wang M, Wang H, Böcker W, Iliakis G
J Cell Physiol. 2005
PubMed ID: 15389585
The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR.
Park BJ, Kang JW, Lee SW, Choi SJ, Shin YK, Ahn YH, Choi YH, Choi D, Lee KS, Kim S
Cell. 2005
PubMed ID: 15680327
Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants.
Di Giacomo M, Barchi M, Baudat F, Edelmann W, Keeney S, Jasin M
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15640358
Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.
Helt CE, Cliby WA, Keng PC, Bambara RA, O'Reilly MA
J Biol Chem. 2005
PubMed ID: 15533933
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
TP53-binding protein variants and breast cancer risk: a case-control study.
Frank B, Hemminki K, Bermejo JL, Klaes R, Bugert P, Wappenschmidt B, Schmutzler RK, Burwinkel B
Breast Cancer Res. 2005
PubMed ID: 15987456
Gene knockouts that cause female infertility: search for novel contraceptive targets.
Naz RK, Rajesh C
Front Biosci. 2005
PubMed ID: 15970507
Atm heterozygous deficiency enhances development of mammary carcinomas in p53 heterozygous knockout mice.
Umesako S, Fujisawa K, Iiga S, Mori N, Takahashi M, Hong DP, Song CW, Haga S, Imai S, Niwa O, Okumoto M
Breast Cancer Res. 2005
PubMed ID: 15642165
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression.
Kang J, Ferguson D, Song H, Bassing C, Eckersdorff M, Alt FW, Xu Y
Mol Cell Biol. 2005
PubMed ID: 15632067
ATM sequence variants are predictive of adverse radiotherapy response among patients treated for prostate cancer.
Cesaretti JA, Stock RG, Lehrer S, Atencio DA, Bernstein JL, Stone NN, Wallenstein S, Green S, Loeb K, Kollmeier M, Smith M, Rosenstein BS
Int J Radiat Oncol Biol Phys. 2005
PubMed ID: 15629612
Cancer risk according to type and location of ATM mutation in ataxia-telangiectasia families.
Cavaciuti E, Laugé A, Janin N, Ossian K, Hall J, Stoppa-Lyonnet D, Andrieu N
Genes Chromosomes Cancer. 2005
PubMed ID: 15390180
Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation.
Jowsey PA, Doherty AJ, Rouse J
J Biol Chem. 2004
PubMed ID: 15456759
Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species.
Kurz EU, Douglas P, Lees-Miller SP
J Biol Chem. 2004
PubMed ID: 15489221
The ATM gene is a target for epigenetic silencing in locally advanced breast cancer.
Vo QN, Kim WJ, Cvitanovic L, Boudreau DA, Ginzinger DG, Brown KD
Oncogene. 2004
PubMed ID: 15516988
NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response.
Polci R, Peng A, Chen PL, Riley DJ, Chen Y
Cancer Res. 2004
PubMed ID: 15604234
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
Riballo E, Kühne M, Rief N, Doherty A, Smith GC, Recio MJ, Reis C, Dahm K, Fricke A, Krempler A, Parker AR, Jackson SP, Gennery A, Jeggo PA, Löbrich M
Mol Cell. 2004
PubMed ID: 15574327
A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint.
Freie BW, Ciccone SL, Li X, Plett PA, Orschell CM, Srour EF, Hanenberg H, Schindler D, Lee SH, Clapp DW
J Biol Chem. 2004
PubMed ID: 15377654
The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm.
Shima N, Munroe RJ, Schimenti JC
Mol Cell Biol. 2004
PubMed ID: 15542845
ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation.
Davalos AR, Kaminker P, Hansen RK, Campisi J
Cell Cycle. 2004
PubMed ID: 15539948
ATM is required for the cellular response to thymidine induced replication fork stress.
Bolderson E, Scorah J, Helleday T, Smythe C, Meuth M
Hum Mol Genet. 2004
PubMed ID: 15459181
Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1.
Shahrabani-Gargir L, Pandita TK, Werner H
Endocrinology. 2004
PubMed ID: 15345673
IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.
Suzuki A, Kusakai G, Kishimoto A, Shimojo Y, Ogura T, Lavin MF, Esumi H
Biochem Biophys Res Commun. 2004
PubMed ID: 15485651
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.
Goodarzi AA, Jonnalagadda JC, Douglas P, Young D, Ye R, Moorhead GB, Lees-Miller SP, Khanna KK
EMBO J. 2004
PubMed ID: 15510216
ATM is required for efficient recombination between immunoglobulin switch regions.
Reina-San-Martin B, Chen HT, Nussenzweig A, Nussenzweig MC
J Exp Med. 2004
PubMed ID: 15520243
Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells.
Liu J, Puscheck EE, Wang F, Trostinskaia A, Barisic D, Maniere G, Wygle D, Zhong W, Rings EH, Rappolee DA
Reproduction. 2004
PubMed ID: 15509711
Immunoglobulin class switch recombination is impaired in Atm-deficient mice.
Lumsden JM, McCarty T, Petiniot LK, Shen R, Barlow C, Wynn TA, Morse HC, Gearhart PJ, Wynshaw-Boris A, Max EE, Hodes RJ
J Exp Med. 2004
PubMed ID: 15504820
Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX.
Ha L, Ceryak S, Patierno SR
Carcinogenesis. 2004
PubMed ID: 15284180
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells.
Ito K, Hirao A, Arai F, Matsuoka S, Takubo K, Hamaguchi I, Nomiyama K, Hosokawa K, Sakurada K, Nakagata N, Ikeda Y, Mak TW, Suda T
Nature. 2004
PubMed ID: 15496926
Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks.
Buscemi G, Perego P, Carenini N, Nakanishi M, Chessa L, Chen J, Khanna K, Delia D
Oncogene. 2004
PubMed ID: 15361830
Iron chelators increase the resistance of Ataxia telangeictasia cells to oxidative stress.
Shackelford RE, Manuszak RP, Johnson CD, Hellrung DJ, Link CJ, Wang S
DNA Repair (Amst). 2004
PubMed ID: 15336622
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.
Zhang X, Succi J, Feng Z, Prithivirajsingh S, Story MD, Legerski RJ
Mol Cell Biol. 2004
PubMed ID: 15456891
c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.
MacLaren A, Black EJ, Clark W, Gillespie DA
Mol Cell Biol. 2004
PubMed ID: 15456874
ATM activity contributes to the tumor-suppressing functions of p14ARF.
Li Y, Wu D, Chen B, Ingram A, He L, Liu L, Zhu D, Kapoor A, Tang D
Oncogene. 2004
PubMed ID: 15258567
Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in the Atm-deficient but not the Trp53-deficient adult cerebral cortex.
McConnell MJ, Kaushal D, Yang AH, Kingsbury MA, Rehen SK, Treuner K, Helton R, Annas EG, Chun J, Barlow C
J Neurosci. 2004
PubMed ID: 15371510
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.
Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC
J Cell Biol. 2004
PubMed ID: 15364958
Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.
Cerosaletti K, Concannon P
J Biol Chem. 2004
PubMed ID: 15234984
Breast cancer in female carriers of ATM gene alterations: outcome of adjuvant radiotherapy.
Meyer A, John E, Dörk T, Sohn C, Karstens JH, Bremer M
Radiother Oncol. 2004
PubMed ID: 15450731
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15302935
ATM polymorphisms as risk factors for prostate cancer development.
Angèle S, Falconer A, Edwards SM, Dörk T, Bremer M, Moullan N, Chapot B, Muir K, Houlston R, Norman AR, Bullock S, Hope Q, Meitz J, Dearnaley D, Dowe A, Southgate C, Ardern-Jones A, Easton DF, Eeles RA, Hall J
Br J Cancer. 2004
PubMed ID: 15280931
Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice.
Schubert R, Erker L, Barlow C, Yakushiji H, Larson D, Russo A, Mitchell JB, Wynshaw-Boris A
Hum Mol Genet. 2004
PubMed ID: 15213104
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.
Karlseder J, Hoke K, Mirzoeva OK, Bakkenist C, Kastan MB, Petrini JH, de Lange T
PLoS Biol. 2004
PubMed ID: 15314656
Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta.
Li B, Wang X, Rasheed N, Hu Y, Boast S, Ishii T, Nakayama K, Nakayama KI, Goff SP
Genes Dev. 2004
PubMed ID: 15289456
Effect of N-acetyl cysteine on oxidative DNA damage and the frequency of DNA deletions in atm-deficient mice.
Reliene R, Fischer E, Schiestl RH
Cancer Res. 2004
PubMed ID: 15289318
Functional consequences of sequence alterations in the ATM gene.
Lavin MF, Scott S, Gueven N, Kozlov S, Peng C, Chen P
DNA Repair (Amst). 2004
PubMed ID: 15279808
PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development.
Huber A, Bai P, de Murcia JM, de Murcia G
DNA Repair (Amst). 2004
PubMed ID: 15279798
53BP1, an activator of ATM in response to DNA damage.
Mochan TA, Venere M, DiTullio RA, Halazonetis TD
DNA Repair (Amst). 2004
PubMed ID: 15279780
The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways.
Abraham RT
DNA Repair (Amst). 2004
PubMed ID: 15279777
DNA damage-induced activation of ATM and ATM-dependent signaling pathways.
Kurz EU, Lees-Miller SP
DNA Repair (Amst). 2004
PubMed ID: 15279774
BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.
Fabbro M, Savage K, Hobson K, Deans AJ, Powell SN, McArthur GA, Khanna KK
J Biol Chem. 2004
PubMed ID: 15159397
Bone marrow transplantation restores immune system function and prevents lymphoma in Atm-deficient mice.
Bagley J, Cortes ML, Breakefield XO, Iacomini J
Blood. 2004
PubMed ID: 15044255
Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.
Cortez D, Glick G, Elledge SJ
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15210935
Polo-like kinase 1 inactivation following mitotic DNA damaging treatments is independent of ataxia telangiectasia mutated kinase.
Yuan JH, Feng Y, Fisher RH, Maloid S, Longo DL, Ferris DK
Mol Cancer Res. 2004
PubMed ID: 15280449
ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage.
Luo Y, Lin FT, Lin WC
Mol Cell Biol. 2004
PubMed ID: 15226443
Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.
Wang X, Andreassen PR, D'Andrea AD
Mol Cell Biol. 2004
PubMed ID: 15199141
Poly(ADP-ribose) polymerase-1 inhibits ATM kinase activity in DNA damage response.
Watanabe F, Fukazawa H, Masutani M, Suzuki H, Teraoka H, Mizutani S, Uehara Y
Biochem Biophys Res Commun. 2004
PubMed ID: 15178448
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.
Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB
Genes Dev. 2004
PubMed ID: 15175241
Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice.
Treuner K, Helton R, Barlow C
Oncogene. 2004
PubMed ID: 15122331
ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP.
Irarrazabal CE, Liu JC, Burg MB, Ferraris JD
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15173573
The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.
Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, Lejeune F, Tibbetts RS, Maquat LE, Abraham RT
Mol Cell. 2004
PubMed ID: 15175154
Adult-onset ataxia telangiectasia due to ATM 5762ins137 mutation homozygosity.
Sutton IJ, Last JI, Ritchie SJ, Harrington HJ, Byrd PJ, Taylor AM
Ann Neurol. 2004
PubMed ID: 15174027
Functional consequences of ATM sequence variants for chromosomal radiosensitivity.
Gutiérrez-Enríquez S, Fernet M, Dörk T, Bremer M, Lauge A, Stoppa-Lyonnet D, Moullan N, Angèle S, Hall J
Genes Chromosomes Cancer. 2004
PubMed ID: 15101044
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
Herbig U, Jobling WA, Chen BP, Chen DJ, Sedivy JM
Mol Cell. 2004
PubMed ID: 15149599
Identification of two mutations for ataxia telangiectasia among the Druze community.
Fares F, Axelord Ran S, David M, Zelnik N, Hecht Y, Khairaldeen H, Lerner A
Prenat Diagn. 2004
PubMed ID: 15164409
Atm-null mice exhibit enhanced radiation-induced birth defects and a hybrid form of embryonic programmed cell death indicating a teratological suppressor function for ATM.
Laposa RR, Henderson JT, Xu E, Wells PG
FASEB J. 2004
PubMed ID: 15033931
Radiation-induced apoptosis in developing mouse retina exhibits dose-dependent requirement for ATM phosphorylation of p53.
Borges HL, Chao C, Xu Y, Linden R, Wang JY
Cell Death Differ. 2004
PubMed ID: 14752509
Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress.
Shi Y, Venkataraman SL, Dodson GE, Mabb AM, LeBlanc S, Tibbetts RS
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15073328
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation.
Horejsí Z, Falck J, Bakkenist CJ, Kastan MB, Lukas J, Bartek J
Oncogene. 2004
PubMed ID: 15048089
Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells.
Golding SE, Rosenberg E, Khalil A, McEwen A, Holmes M, Neill S, Povirk LF, Valerie K
J Biol Chem. 2004
PubMed ID: 14744854
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
Lee JH, Paull TT
Science. 2004
PubMed ID: 15064416
E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis.
Powers JT, Hong S, Mayhew CN, Rogers PM, Knudsen ES, Johnson DG
Mol Cancer Res. 2004
PubMed ID: 15140942
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
A Ser49Cys variant in the ataxia telangiectasia, mutated, gene that is more common in patients with breast carcinoma compared with population controls.
Buchholz TA, Weil MM, Ashorn CL, Strom EA, Sigurdson A, Bondy M, Chakraborty R, Cox JD, McNeese MD, Story MD
Cancer. 2004
PubMed ID: 15042666
Five haplotypes account for fifty-five percent of ATM mutations in Brazilian patients with ataxia telangiectasia: seven new mutations.
Coutinho G, Mitui M, Campbell C, Costa Carvalho BT, Nahas S, Sun X, Huo Y, Lai CH, Thorstenson Y, Tanouye R, Raskin S, Kim CA, Llerena J, Gatti RA
Am J Med Genet A. 2004
PubMed ID: 15039971
Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2.
Rogoff HA, Pickering MT, Frame FM, Debatis ME, Sanchez Y, Jones S, Kowalik TF
Mol Cell Biol. 2004
PubMed ID: 15024084
Analysis of ataxia-telangiectasia mutated (ATM)- and Nijmegen breakage syndrome (NBS)-regulated gene expression patterns.
Jang ER, Lee JH, Lim DS, Lee JS
J Cancer Res Clin Oncol. 2004
PubMed ID: 14745549
Ataxia telangiectasia mutated expression and activation in the testis.
Hamer G, Kal HB, Westphal CH, Ashley T, de Rooij DG
Biol Reprod. 2004
PubMed ID: 14681204
Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.
Aleyasin H, Cregan SP, Iyirhiaro G, O'Hare MJ, Callaghan SM, Slack RS, Park DS
J Neurosci. 2004
PubMed ID: 15044535
Progressive sensorimotor impairment is not associated with reduced dopamine and high energy phosphate donors in a model of ataxia-telangiectasia.
Mount HT, Martel JC, Fluit P, Wu Y, Gallo-Hendrikx E, Cosi C, Marien MR
J Neurochem. 2004
PubMed ID: 15009646
ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.
Panta GR, Kaur S, Cavin LG, Cortés ML, Mercurio F, Lothstein L, Sweatman TW, Israel M, Arsura M
Mol Cell Biol. 2004
PubMed ID: 14966265
X-ray-induced telomeric instability in Atm-deficient mouse cells.
Undarmaa B, Kodama S, Suzuki K, Niwa O, Watanabe M
Biochem Biophys Res Commun. 2004
PubMed ID: 15013424
DNA damage tumor suppressor genes and genomic instability.
Motoyama N, Naka K
Curr Opin Genet Dev. 2004
PubMed ID: 15108799
ATM protein overexpression in prostate tumors: possible role in telomere maintenance.
Angèle S, Falconer A, Foster CS, Taniere P, Eeles RA, Hall J
Am J Clin Pathol. 2004
PubMed ID: 14983937
ATM gene and lymphoid malignancies.
Gumy-Pause F, Wacker P, Sappino AP
Leukemia. 2004
PubMed ID: 14628072
Molecular variants of the ATM gene in Hodgkin's disease in children.
Liberzon E, Avigad S, Yaniv I, Stark B, Avrahami G, Goshen Y, Zaizov R
Br J Cancer. 2004
PubMed ID: 14735203
Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts.
Naka K, Tachibana A, Ikeda K, Motoyama N
J Biol Chem. 2004
PubMed ID: 14570874
A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity.
Kühne M, Riballo E, Rief N, Rothkamm K, Jeggo PA, Löbrich M
Cancer Res. 2004
PubMed ID: 14744762
The mammalian mid-pachytene checkpoint: meiotic arrest in spermatocytes with a mutation in Atm alone or in combination with a Trp53 (p53) or Cdkn1a (p21/cip1) mutation.
Ashley T, Westphal C, Plug-de Maggio A, de Rooij DG
Cytogenet Genome Res. 2004
PubMed ID: 15467370
Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case-control study.
Tamimi RM, Hankinson SE, Spiegelman D, Kraft P, Colditz GA, Hunter DJ
Breast Cancer Res. 2004
PubMed ID: 15217510
Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study.
Bernstein JL, Langholz B, Haile RW, Bernstein L, Thomas DC, Stovall M, Malone KE, Lynch CF, Olsen JH, Anton-Culver H, Shore RE, Boice JD, Berkowitz GS, Gatti RA, Teitelbaum SL, Smith SA, Rosenstein BS, Børresen-Dale AL, Concannon P, Thompson WD, WECARE study
Breast Cancer Res. 2004
PubMed ID: 15084244
ATM mutations in B-cell chronic lymphocytic leukemia.
Lähdesmäki A, Kimby E, Duke V, Foroni L, Hammarström L
Haematologica. 2004
PubMed ID: 14754616
Nonclassical splicing mutations in the coding and noncoding regions of the ATM Gene: maximum entropy estimates of splice junction strengths.
Eng L, Coutinho G, Nahas S, Yeo G, Tanouye R, Babaei M, Dörk T, Burge C, Gatti RA
Hum Mutat. 2004
PubMed ID: 14695534
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease.
Takagi M, Tsuchida R, Oguchi K, Shigeta T, Nakada S, Shimizu K, Ohki M, Delia D, Chessa L, Taya Y, Nakanishi M, Tsunematsu Y, Bessho F, Isoyama K, Hayashi Y, Kudo K, Okamura J, Mizutani S
Blood. 2004
PubMed ID: 12969974
Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses.
Stankovic T, Hubank M, Cronin D, Stewart GS, Fletcher D, Bignell CR, Alvi AJ, Austen B, Weston VJ, Fegan C, Byrd PJ, Moss PA, Taylor AM
Blood. 2004
PubMed ID: 12958068
ATM haplotypes and cellular response to DNA damage: association with breast cancer risk and clinical radiosensitivity.
Angèle S, Romestaing P, Moullan N, Vuillaume M, Chapot B, Friesen M, Jongmans W, Cox DG, Pisani P, Gérard JP, Hall J
Cancer Res. 2003
PubMed ID: 14695186
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.
Mochan TA, Venere M, DiTullio RA, Halazonetis TD
Cancer Res. 2003
PubMed ID: 14695167
The Mre11 complex is required for ATM activation and the G2/M checkpoint.
Carson CT, Schwartz RA, Stracker TH, Lilley CE, Lee DV, Weitzman MD
EMBO J. 2003
PubMed ID: 14657032
Oxidative stress is responsible for deficient survival and dendritogenesis in purkinje neurons from ataxia-telangiectasia mutated mutant mice.
Chen P, Peng C, Luff J, Spring K, Watters D, Bottle S, Furuya S, Lavin MF
J Neurosci. 2003
PubMed ID: 14673010
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice.
Theunissen JW, Kaplan MI, Hunt PA, Williams BR, Ferguson DO, Alt FW, Petrini JH
Mol Cell. 2003
PubMed ID: 14690604
Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.
Qi L, Strong MA, Karim BO, Armanios M, Huso DL, Greider CW
Cancer Res. 2003
PubMed ID: 14678974
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Clinical radiosensitivity in breast cancer patients carrying pathogenic ATM gene mutations: no observation of increased radiation-induced acute or late effects.
Bremer M, Klöpper K, Yamini P, Bendix-Waltes R, Dörk T, Karstens JH
Radiother Oncol. 2003
PubMed ID: 14643952
DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase.
Yuan L, Yu WM, Qu CK
J Biol Chem. 2003
PubMed ID: 12937170
ATM variants 7271T>G and IVS10-6T>G among women with unilateral and bilateral breast cancer.
Bernstein JL, Bernstein L, Thompson WD, Lynch CF, Malone KE, Teitelbaum SL, Olsen JH, Anton-Culver H, Boice JD, Rosenstein BS, Børresen-Dale AL, Gatti RA, Concannon P, Haile RW, WECARE Study Collaborative Group
Br J Cancer. 2003
PubMed ID: 14562025
ATM gene mutations are not involved in medulloblastoma in children.
Liberzon E, Avigad S, Cohen IJ, Yaniv I, Michovitz S, Zaizov R
Cancer Genet Cytogenet. 2003
PubMed ID: 14553952
Requirement of the MRN complex for ATM activation by DNA damage.
Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y
EMBO J. 2003
PubMed ID: 14532133
Atm and c-Abl cooperate in the response to genotoxic stress during nervous system development.
Miller HL, Lee Y, Zhao J, Chong MJ, McKinnon PJ
Brain Res Dev Brain Res. 2003
PubMed ID: 14519491
NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.
Xu X, Stern DF
FASEB J. 2003
PubMed ID: 14519663
Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.
Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA
Exp Cell Res. 2003
PubMed ID: 14499622
ATM mutations and protein expression are not associated with familial B-CLL cases.
Ishibe N, Goldin LR, Caporaso NE, Sgambati MT, Dean M, Albitar M, Manshouri T, Gerrard B, Marti GE
Leuk Res. 2003
PubMed ID: 12860021
Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.
Keramaris E, Hirao A, Slack RS, Mak TW, Park DS
J Biol Chem. 2003
PubMed ID: 12857758
DNA damage induced by polyglutamine-expanded proteins.
Giuliano P, De Cristofaro T, Affaitati A, Pizzulo GM, Feliciello A, Criscuolo C, De Michele G, Filla A, Avvedimento EV, Varrone S
Hum Mol Genet. 2003
PubMed ID: 12915485
Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.
Krause DR, Jonnalagadda JC, Gatei MH, Sillje HH, Zhou BB, Nigg EA, Khanna K
Oncogene. 2003
PubMed ID: 12955071
Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development.
Bishop AJ, Hollander MC, Kosaras B, Sidman RL, Fornace AJ, Schiestl RH
Cancer Res. 2003
PubMed ID: 14500365
ATM missense mutations are frequent in patients with breast cancer.
Sommer SS, Jiang Z, Feng J, Buzin CH, Zheng J, Longmate J, Jung M, Moulds J, Dritschilo A
Cancer Genet Cytogenet. 2003
PubMed ID: 12935922
ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation.
Heinloth AN, Shackelford RE, Innes CL, Bennett L, Li L, Amin RP, Sieber SO, Flores KG, Bushel PR, Paules RS
Radiat Res. 2003
PubMed ID: 12926986
The relationship between twenty missense ATM variants and breast cancer risk: the Multiethnic Cohort.
Bretsky P, Haiman CA, Gilad S, Yahalom J, Grossman A, Paglin S, Van Den Berg D, Kolonel LN, Skaliter R, Henderson BE
Cancer Epidemiol Biomarkers Prev. 2003
PubMed ID: 12917204
Idiopathic and radiation-induced ocular telangiectasia: the involvement of the ATM gene.
Mauget-Faÿsse M, Vuillaume M, Quaranta M, Moullan N, Angèle S, Friesen MD, Hall J
Invest Ophthalmol Vis Sci. 2003
PubMed ID: 12882767
Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias.
Starczynski J, Simmons W, Flavell JR, Byrd PJ, Stewart GS, Kullar HS, Groom A, Crocker J, Moss PA, Reynolds GM, Glavina-Durdov M, Taylor AM, Fegan C, Stankovic T, Murray PG
Am J Pathol. 2003
PubMed ID: 12875964
Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling.
Roos-Mattjus P, Hopkins KM, Oestreich AJ, Vroman BT, Johnson KL, Naylor S, Lieberman HB, Karnitz LM
J Biol Chem. 2003
PubMed ID: 12709442
Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2.
Kool J, Hamdi M, Cornelissen-Steijger P, van der Eb AJ, Terleth C, van Dam H
Oncogene. 2003
PubMed ID: 12833146
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
Lee JH, Xu B, Lee CH, Ahn JY, Song MS, Lee H, Canman CE, Lee JS, Kastan MB, Lim DS
Mol Cancer Res. 2003
PubMed ID: 12861053
Independent mutational events are rare in the ATM gene: haplotype prescreening enhances mutation detection rate.
Mitui M, Campbell C, Coutinho G, Sun X, Lai CH, Thorstenson Y, Castellvi-Bel S, Fernandez L, Monros E, Carvalho BT, Porras O, Fontan G, Gatti RA
Hum Mutat. 2003
PubMed ID: 12815592
Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA.
Llorca O, Rivera-Calzada A, Grantham J, Willison KR
Oncogene. 2003
PubMed ID: 12813460
Contributions of ATM mutations to familial breast and ovarian cancer.
Thorstenson YR, Roxas A, Kroiss R, Jenkins MA, Yu KM, Bachrich T, Muhr D, Wayne TL, Chu G, Davis RW, Wagner TM, Oefner PJ
Cancer Res. 2003
PubMed ID: 12810666
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.
Foray N, Marot D, Gabriel A, Randrianarison V, Carr AM, Perricaudet M, Ashworth A, Jeggo P
EMBO J. 2003
PubMed ID: 12773400
Histone deacetylase inhibitors activate p21(WAF1) expression via ATM.
Ju R, Muller MT
Cancer Res. 2003
PubMed ID: 12782595
Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX.
Ward IM, Minn K, Jorda KG, Chen J
J Biol Chem. 2003
PubMed ID: 12697768
Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest.
Ha L, Ceryak S, Patierno SR
J Biol Chem. 2003
PubMed ID: 12637545
Missense mutation and defective function of ATM in a childhood acute leukemia patient with MLL gene rearrangement.
Oguchi K, Takagi M, Tsuchida R, Taya Y, Ito E, Isoyama K, Ishii E, Zannini L, Delia D, Mizutani S
Blood. 2003
PubMed ID: 12511424
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation.
Gatei M, Sloper K, Sorensen C, Syljuäsen R, Falck J, Hobson K, Savage K, Lukas J, Zhou BB, Bartek J, Khanna KK
J Biol Chem. 2003
PubMed ID: 12588868
Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells.
Yuan SS, Chang HL, Lee EY
Mutat Res. 2003
PubMed ID: 12650908
Single-stranded DNA induces ataxia telangiectasia mutant (ATM)/p53-dependent DNA damage and apoptotic signals.
Nur-E-Kamal A, Li TK, Zhang A, Qi H, Hars ES, Liu LF
J Biol Chem. 2003
PubMed ID: 12540848
ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation.
Hammond EM, Dorie MJ, Giaccia AJ
J Biol Chem. 2003
PubMed ID: 12519769
Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.
Groth A, Lukas J, Nigg EA, Silljé HH, Wernstedt C, Bartek J, Hansen K
EMBO J. 2003
PubMed ID: 12660173
ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region.
Pan-Hammarström Q, Dai S, Zhao Y, van Dijk-Härd IF, Gatti RA, Børresen-Dale AL, Hammarström L
J Immunol. 2003
PubMed ID: 12646636
Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9.
Yoshida K, Wang HG, Miki Y, Kufe D
EMBO J. 2003
PubMed ID: 12628935
ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation.
Kozlov S, Gueven N, Keating K, Ramsay J, Lavin MF
J Biol Chem. 2003
PubMed ID: 12645530
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody.
Tsvetkov L, Xu X, Li J, Stern DF
J Biol Chem. 2003
PubMed ID: 12493754
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.
Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou BB, Bartek J, Lukas J
Cancer Cell. 2003
PubMed ID: 12676583
Mammalian meiosis involves DNA double-strand breaks with 3' overhangs.
Zenvirth D, Richler C, Bardhan A, Baudat F, Barzilai A, Wahrman J, Simchen G
Chromosoma. 2003
PubMed ID: 12644952
ATM and related protein kinases: safeguarding genome integrity.
Shiloh Y
Nat Rev Cancer. 2003
PubMed ID: 12612651
The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation.
Wang X, Li W, Parra JL, Beugnet A, Proud CG
Mol Cell Biol. 2003
PubMed ID: 12588975
Contribution of the Atm protein to maintaining cellular homeostasis evidenced by continuous activation of the AP-1 pathway in Atm-deficient brains.
Weizman N, Shiloh Y, Barzilai A
J Biol Chem. 2003
PubMed ID: 12496286
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ
Nature. 2003
PubMed ID: 12607005
MDC1 is required for the intra-S-phase DNA damage checkpoint.
Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, Bartek J, Jackson SP
Nature. 2003
PubMed ID: 12607003
Reduced NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein.
Macleod MR, Ramage L, McGregor A, Seckl JR
Neuroreport. 2003
PubMed ID: 12598732
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA
Nature. 2003
PubMed ID: 12540856
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
Bakkenist CJ, Kastan MB
Nature. 2003
PubMed ID: 12556884
Aberrant sensing of extracellular Ca2+ by cultured ataxia telangiectasia fibroblasts.
Famulski KS, Al-Hijailan RS, Dobler K, Pienkowska M, Al-Mohanna F, Paterson MC
Oncogene. 2003
PubMed ID: 12545170
Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein.
Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Lavin MF, Esumi H
J Biol Chem. 2003
PubMed ID: 12409306
Late degeneration of nigro-striatal neurons in ATM-/- mice.
Eilam R, Peter Y, Groner Y, Segal M
Neuroscience. 2003
PubMed ID: 12946702
Association of ataxia telangiectasia mutated (ATM) gene mutation/deletion with rhabdomyosarcoma.
Zhang P, Bhakta KS, Puri PL, Newbury RO, Feramisco JR, Wang JY
Cancer Biol Ther. 2003
PubMed ID: 12673126
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Upregulation of FasL and apoptosis in thymic lymphomas in Atm knock-in mice.
Lavin MF, Spring K
Toxicology. 2002
PubMed ID: 12505357
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
ATR regulates fragile site stability.
Casper AM, Nghiem P, Arlt MF, Glover TW
Cell. 2002
PubMed ID: 12526805
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancers.
Offit K, Gilad S, Paglin S, Kolachana P, Roisman LC, Nafa K, Yeugelewitz V, Gonzales M, Robson M, McDermott D, Pierce HH, Kauff ND, Einat P, Jhanwar S, Satagopan JM, Oddoux C, Ellis N, Skaliter R, Yahalom J
Clin Cancer Res. 2002
PubMed ID: 12473594
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.
Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A
Nat Cell Biol. 2002
PubMed ID: 12447390
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR
Biochem J. 2002
PubMed ID: 12234250
Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway.
Pamment J, Ramsay E, Kelleher M, Dornan D, Ball KL
Oncogene. 2002
PubMed ID: 12420214
ATM is activated in response to N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA alkylation.
Adamson AW, Kim WJ, Shangary S, Baskaran R, Brown KD
J Biol Chem. 2002
PubMed ID: 12151394
Deficiency in the repair of UV-induced DNA damage in human skin fibroblasts compromised for the ATM gene.
Hannan MA, Hellani A, Al-Khodairy FM, Kunhi M, Siddiqui Y, Al-Yussef N, Pangue-Cruz N, Siewertsen M, Al-Ahdal MN, Aboussekhra A
Carcinogenesis. 2002
PubMed ID: 12376469
Constitutional alterations of the ATM gene in early onset sporadic breast cancer.
Maillet P, Bonnefoi H, Vaudan-Vutskits G, Pajk B, Cufer T, Foulkes WD, Chappuis PO, Sappino AP
J Med Genet. 2002
PubMed ID: 12362033
Mouse models of male infertility.
Cooke HJ, Saunders PT
Nat Rev Genet. 2002
PubMed ID: 12360237
Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways.
Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ
Oncogene. 2002
PubMed ID: 12242661
Prevention of thymic lymphoma development in Atm-/- mice by dexamethasone.
Yan M, Kuang X, Qiang W, Shen J, Claypool K, Lynn WS, Wong PK
Cancer Res. 2002
PubMed ID: 12234978
Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.
Spring K, Ahangari F, Scott SP, Waring P, Purdie DM, Chen PC, Hourigan K, Ramsay J, McKinnon PJ, Swift M, Lavin MF
Nat Genet. 2002
PubMed ID: 12195425
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, Elledge SJ, Mak TW
Mol Cell Biol. 2002
PubMed ID: 12192050
Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM.
Beamish H, Kedar P, Kaneko H, Chen P, Fukao T, Peng C, Beresten S, Gueven N, Purdie D, Lees-Miller S, Ellis N, Kondo N, Lavin MF
J Biol Chem. 2002
PubMed ID: 12034743
ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma.
Grønbaek K, Worm J, Ralfkiaer E, Ahrenkiel V, Hokland P, Guldberg P
Blood. 2002
PubMed ID: 12149228
Atm heterozygous mice are more sensitive to radiation-induced cataracts than are their wild-type counterparts.
Worgul BV, Smilenov L, Brenner DJ, Junk A, Zhou W, Hall EJ
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12119422
Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response.
Jack MT, Woo RA, Hirao A, Cheung A, Mak TW, Lee PW
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12097646
ATM mutations are rare in familial chronic lymphocytic leukemia.
Yuille MR, Condie A, Hudson CD, Bradshaw PS, Stone EM, Matutes E, Catovsky D, Houlston RS
Blood. 2002
PubMed ID: 12091354
Re: Dominant negative ATM mutations in breast cancer families.
Lei H, Pospisilova D, Lindblom A, Vorechovsky I
J Natl Cancer Inst. 2002
PubMed ID: 12072552
Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes.
Korz C, Pscherer A, Benner A, Mertens D, Schaffner C, Leupolt E, Döhner H, Stilgenbauer S, Lichter P
Blood. 2002
PubMed ID: 12036888
Cellular responses to the DNA strand-scission enediyne C-1027 can be independent of ATM, ATR, and DNA-PK kinases.
Dziegielewski J, Beerman TA
J Biol Chem. 2002
PubMed ID: 11927575
Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.
Yoshida M, Hosoi Y, Miyachi H, Ishii N, Matsumoto Y, Enomoto A, Nakagawa K, Yamada S, Suzuki N, Ono T
Int J Radiat Biol. 2002
PubMed ID: 12065055
Effect of germ-line genetic variation on breast cancer survival in a population-based study.
Goode EL, Dunning AM, Kuschel B, Healey CS, Day NE, Ponder BA, Easton DF, Pharoah PP
Cancer Res. 2002
PubMed ID: 12036913
Chk2 activation and phosphorylation-dependent oligomerization.
Xu X, Tsvetkov LM, Stern DF
Mol Cell Biol. 2002
PubMed ID: 12024051
Variation in breast cancer risk of heterozygotes for ataxia-telangiectasia according to environmental factors.
Geoffroy-Perez B, Janin N, Ossian K, Laugé A, Stoppa-Lyonnet D, Andrieu N
Int J Cancer. 2002
PubMed ID: 11992555
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD
Science. 2002
PubMed ID: 12040188
Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain.
Ahn JY, Li X, Davis HL, Canman CE
J Biol Chem. 2002
PubMed ID: 11901158
Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line.
Kim WJ, Vo QN, Shrivastav M, Lataxes TA, Brown KD
Oncogene. 2002
PubMed ID: 12032824
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.
Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, Kim ST, Lane WS, Kastan MB, D'Andrea AD
Cell. 2002
PubMed ID: 12086603
Degradation of ATM-independent decatenation checkpoint function in human cells is secondary to inactivation of p53 and correlated with chromosomal destabilization.
Kaufmann WK, Campbell CB, Simpson DA, Deming PB, Filatov L, Galloway DA, Zhao XJ, Creighton AM, Downes CS
Cell Cycle. 2002
PubMed ID: 12429935
RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice.
Petiniot LK, Weaver Z, Vacchio M, Shen R, Wangsa D, Barlow C, Eckhaus M, Steinberg SM, Wynshaw-Boris A, Ried T, Hodes RJ
Mol Cell Biol. 2002
PubMed ID: 11940674
A murine model of Nijmegen breakage syndrome.
Williams BR, Mirzoeva OK, Morgan WF, Lin J, Dunnick W, Petrini JH
Curr Biol. 2002
PubMed ID: 11967151
ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation.
Saito S, Goodarzi AA, Higashimoto Y, Noda Y, Lees-Miller SP, Appella E, Anderson CW
J Biol Chem. 2002
PubMed ID: 11875057
Elevated frequency of ATM gene missense mutations in breast cancer relative to ethnically matched controls.
Sommer SS, Buzin CH, Jung M, Zheng J, Liu Q, Jeong SJ, Moulds J, Nguyen VQ, Feng J, Bennett WP, Dritschilo A
Cancer Genet Cytogenet. 2002
PubMed ID: 11996792
Histone H2A variants H2AX and H2AZ.
Redon C, Pilch D, Rogakou E, Sedelnikova O, Newrock K, Bonner W
Curr Opin Genet Dev. 2002
PubMed ID: 11893489
A new type of mutation causes a splicing defect in ATM.
Pagani F, Buratti E, Stuani C, Bendix R, Dörk T, Baralle FE
Nat Genet. 2002
PubMed ID: 11889466
Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle.
Nakamura M, Zhou XZ, Kishi S, Lu KP
FEBS Lett. 2002
PubMed ID: 11943150
ATM mutations in Finnish breast cancer patients.
Allinen M, Launonen V, Laake K, Jansen L, Huusko P, Kääriäinen H, Børresen-Dale AL, Winqvist R
J Med Genet. 2002
PubMed ID: 11897822
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.
Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J
Genes Dev. 2002
PubMed ID: 11877377
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage.
Kim ST, Xu B, Kastan MB
Genes Dev. 2002
PubMed ID: 11877376
Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome.
Sapkota GP, Boudeau J, Deak M, Kieloch A, Morrice N, Alessi DR
Biochem J. 2002
PubMed ID: 11853558
Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus.
Tan Z, Sankar R, Tu W, Shin D, Liu H, Wasterlain CG, Schreiber SS
Brain Res. 2002
PubMed ID: 11852039
ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects.
Iannuzzi CM, Atencio DP, Green S, Stock RG, Rosenstein BS
Int J Radiat Oncol Biol Phys. 2002
PubMed ID: 11849780
ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation.
Guo CY, Brautigan DL, Larner JM
J Biol Chem. 2002
PubMed ID: 11723136
Dominant negative ATM mutations in breast cancer families.
Chenevix-Trench G, Spurdle AB, Gatei M, Kelly H, Marsh A, Chen X, Donn K, Cummings M, Nyholt D, Jenkins MA, Scott C, Pupo GM, Dörk T, Bendix R, Kirk J, Tucker K, McCredie MR, Hopper JL, Sambrook J, Mann GJ, Khanna KK
J Natl Cancer Inst. 2002
PubMed ID: 11830610
Consortium piecing together role of ATM gene in breast cancer.
Finkel E
J Natl Cancer Inst. 2002
PubMed ID: 11830600
[ATM and Cancer]
Tang Y
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2002
PubMed ID: 12513844
Requirement of ATM in UVA-induced signaling and apoptosis.
Zhang Y, Ma WY, Kaji A, Bode AM, Dong Z
J Biol Chem. 2002
PubMed ID: 11723137
Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer.
Scott SP, Bendix R, Chen P, Clark R, Dork T, Lavin MF
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11805335
Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice.
Stern N, Hochman A, Zemach N, Weizman N, Hammel I, Shiloh Y, Rotman G, Barzilai A
J Biol Chem. 2002
PubMed ID: 11679583
No evidence for association of ataxia-telangiectasia mutated gene T2119C and C3161G amino acid substitution variants with risk of breast cancer.
Spurdle AB, Hopper JL, Chen X, McCredie MR, Giles GG, Newman B, Chenevix-Trench G, Khanna K
Breast Cancer Res. 2002
PubMed ID: 12473176
ATM: from phenotype to functional genomics--and back.
Shiloh Y
Ernst Schering Res Found Workshop. 2002
PubMed ID: 11859564
A late onset variant of ataxia-telangiectasia with a compound heterozygous genotype, A8030G/7481insA.
Saviozzi S, Saluto A, Taylor AM, Last JI, Trebini F, Paradiso MC, Grosso E, Funaro A, Ponzio G, Migone N, Brusco A
J Med Genet. 2002
PubMed ID: 11826028
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.
D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S, Gostissa M, Coen S, Marchetti A, Del Sal G, Piaggio G, Fanciulli M, Appella E, Soddu S
Nat Cell Biol. 2002
PubMed ID: 11780126
A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.
Yamane K, Wu X, Chen J
Mol Cell Biol. 2002
PubMed ID: 11756551
Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat.
Silins I, Finnberg N, Ståhl A, Högberg J, Stenius U
Carcinogenesis. 2001
PubMed ID: 11751435
Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.
Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W
J Biol Chem. 2001
PubMed ID: 11551930
ATM phosphorylates histone H2AX in response to DNA double-strand breaks.
Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ
J Biol Chem. 2001
PubMed ID: 11571274
Effect of DNA damage on a BRCA1 complex.
Wu-Baer F, Baer R
Nature. 2001
PubMed ID: 11689934
Spectrum of ATM gene mutations in a hospital-based series of unselected breast cancer patients.
Dörk T, Bendix R, Bremer M, Rades D, Klöpper K, Nicke M, Skawran B, Hector A, Yamini P, Steinmann D, Weise S, Stuhrmann M, Karstens JH
Cancer Res. 2001
PubMed ID: 11606401
UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts.
Latonen L, Taya Y, Laiho M
Oncogene. 2001
PubMed ID: 11709713
Mpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis.
Pestina TI, Cleveland JL, Yang C, Zambetti GP, Jackson CW
Blood. 2001
PubMed ID: 11567994
Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status.
Lee Y, Chong MJ, McKinnon PJ
J Neurosci. 2001
PubMed ID: 11517258
Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks.
Kishi S, Zhou XZ, Ziv Y, Khoo C, Hill DE, Shiloh Y, Lu KP
J Biol Chem. 2001
PubMed ID: 11375976
Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells.
Smilenov LB, Brenner DJ, Hall EJ
Cancer Res. 2001
PubMed ID: 11479203
Radiation induces genomic instability and mammary ductal dysplasia in Atm heterozygous mice.
Weil MM, Kittrell FS, Yu Y, McCarthy M, Zabriskie RC, Ullrich RL
Oncogene. 2001
PubMed ID: 11466622
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.
Lin WC, Lin FT, Nevins JR
Genes Dev. 2001
PubMed ID: 11459832
Ataxia telangiectasia gene mutations in leukaemia and lymphoma.
Boultwood J
J Clin Pathol. 2001
PubMed ID: 11429421
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1.
Zhao H, Piwnica-Worms H
Mol Cell Biol. 2001
PubMed ID: 11390642
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.
Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, Chen SM, Abraham RT, Wang XF
Nature. 2001
PubMed ID: 11418864
The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts.
Shackelford RE, Innes CL, Sieber SO, Heinloth AN, Leadon SA, Paules RS
J Biol Chem. 2001
PubMed ID: 11290740
Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function.
Morita Y, Maravei DV, Bergeron L, Wang S, Perez GI, Tsutsumi O, Taketani Y, Asano M, Horai R, Korsmeyer SJ, Iwakura Y, Yuan J, Tilly JL
Cell Death Differ. 2001
PubMed ID: 11536012
Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype.
Spring K, Cross S, Li C, Watters D, Ben-Senior L, Waring P, Ahangari F, Lu SL, Chen P, Misko I, Paterson C, Kay G, Smorodinsky NI, Shiloh Y, Lavin MF
Cancer Res. 2001
PubMed ID: 11389091
Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies.
Gatei M, Zhou BB, Hobson K, Scott S, Young D, Khanna KK
J Biol Chem. 2001
PubMed ID: 11278964
ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation.
Chen MJ, Lin YT, Lieberman HB, Chen G, Lee EY
J Biol Chem. 2001
PubMed ID: 11278446
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
Maya R, Balass M, Kim ST, Shkedy D, Leal JF, Shifman O, Moas M, Buschmann T, Ronai Z, Shiloh Y, Kastan MB, Katzir E, Oren M
Genes Dev. 2001
PubMed ID: 11331603
Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice.
Peter Y, Rotman G, Lotem J, Elson A, Shiloh Y, Groner Y
EMBO J. 2001
PubMed ID: 11285218
Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.
Sekiguchi J, Ferguson DO, Chen HT, Yang EM, Earle J, Frank K, Whitlow S, Gu Y, Xu Y, Nussenzweig A, Alt FW
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11248063
Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice.
Vemuri MC, Schiller E, Naegele JR
Cell Death Differ. 2001
PubMed ID: 11319607
Novel mutations and defective protein kinase C activation of T-lymphocytes in ataxia telangiectasia.
García-Pérez MA, Allende LM, Corell A, Varela P, Moreno AA, Sotoca A, Moreno A, Paz-Artal E, Barreiro E, Arnaiz-Villena A
Clin Exp Immunol. 2001
PubMed ID: 11298136
Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development.
Ménisser-de Murcia J, Mark M, Wendling O, Wynshaw-Boris A, de Murcia G
Mol Cell Biol. 2001
PubMed ID: 11238919
Ataxia telangiectasia mutated is essential during adult neurogenesis.
Allen DM, van Praag H, Ray J, Weaver Z, Winrow CJ, Carter TA, Braquet R, Harrington E, Ried T, Brown KD, Gage FH, Barlow C
Genes Dev. 2001
PubMed ID: 11238376
Extra-chromosomal telomeric DNA in cells from Atm(-/-) mice and patients with ataxia-telangiectasia.
Hande MP, Balajee AS, Tchirkov A, Wynshaw-Boris A, Lansdorp PM
Hum Mol Genet. 2001
PubMed ID: 11181576
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis.
Gurley KE, Kemp CJ
Curr Biol. 2001
PubMed ID: 11231155
Heterozygosity for a mutation in Brca1 or Atm does not increase susceptibility to ENU-induced mammary tumors in Apc(Min)/+ mice.
Karabinis ME, Larson D, Barlow C, Wynshaw-Boris A, Moser AR
Carcinogenesis. 2001
PubMed ID: 11181458
Influence of angiotensin II type 1 receptor polymorphism on hypertension in patients with hypercholesterolemia.
Morisawa T, Kishimoto Y, Kitano M, Kawasaki H, Hasegawa J
Clin Chim Acta. 2001
PubMed ID: 11165203
Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.
Daniel R, Katz RA, Merkel G, Hittle JC, Yen TJ, Skalka AM
Mol Cell Biol. 2001
PubMed ID: 11158303
The many substrates and functions of ATM.
Kastan MB, Lim DS
Nat Rev Mol Cell Biol. 2000
PubMed ID: 11252893
Loss of heterozygosity in bilateral breast cancer.
Kollias J, Man S, Marafie M, Carpenter K, Pinder S, Ellis IO, Blamey RW, Cross G, Brook JD
Breast Cancer Res Treat. 2000
PubMed ID: 11200774
Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.
Yang DQ, Kastan MB
Nat Cell Biol. 2000
PubMed ID: 11146653
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.
Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, Abraham RT
Genes Dev. 2000
PubMed ID: 11114888
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm.
Lee Y, Barnes DE, Lindahl T, McKinnon PJ
Genes Dev. 2000
PubMed ID: 11040211
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.
Scherthan H, Jerratsch M, Dhar S, Wang YA, Goff SP, Pandita TK
Mol Cell Biol. 2000
PubMed ID: 11003672
Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks.
Bhandoola A, Dolnick B, Fayad N, Nussenzweig A, Singer A
J Exp Med. 2000
PubMed ID: 10993919
Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage.
Chen J
Cancer Res. 2000
PubMed ID: 11016625
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.
Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10973490
Abnormal rearrangement within the alpha/delta T-cell receptor locus in lymphomas from Atm-deficient mice.
Liyanage M, Weaver Z, Barlow C, Coleman A, Pankratz DG, Anderson S, Wynshaw-Boris A, Ried T
Blood. 2000
PubMed ID: 10961898
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM
Curr Biol. 2000
PubMed ID: 10959836
Expression pattern of the Nijmegen breakage syndrome gene, Nbs1, during murine development.
Wilda M, Demuth I, Concannon P, Sperling K, Hameister H
Hum Mol Genet. 2000
PubMed ID: 10915761
Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response.
Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH
Nature. 2000
PubMed ID: 10910365
Role for ATM in DNA damage-induced phosphorylation of BRCA1.
Gatei M, Scott SP, Filippovitch I, Soronika N, Lavin MF, Weber B, Khanna KK
Cancer Res. 2000
PubMed ID: 10866324
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.
Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ
Genes Dev. 2000
PubMed ID: 10859164
Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice.
Petiniot LK, Weaver Z, Barlow C, Shen R, Eckhaus M, Steinberg SM, Ried T, Wynshaw-Boris A, Hodes RJ
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10841564
Ataxia-telangiectasia: phenotype/genotype studies of ATM protein expression, mutations, and radiosensitivity.
Becker-Catania SG, Chen G, Hwang MJ, Wang Z, Sun X, Sanal O, Bernatowska-Matuszkiewicz E, Chessa L, Lee EY, Gatti RA
Mol Genet Metab. 2000
PubMed ID: 10873394
Mutations at the ataxia-telangiectasia locus and clinical phenotypes of A-T patients.
Li A, Swift M
Am J Med Genet. 2000
PubMed ID: 10817650
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response.
Wu X, Ranganathan V, Weisman DS, Heine WF, Ciccone DN, O'Neill TB, Crick KE, Pierce KA, Lane WS, Rathbun G, Livingston DM, Weaver DT
Nature. 2000
PubMed ID: 10839545
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products.
Zhao S, Weng YC, Yuan SS, Lin YT, Hsu HC, Lin SC, Gerbino E, Song MH, Zdzienicka MZ, Gatti RA, Shay JW, Ziv Y, Shiloh Y, Lee EY
Nature. 2000
PubMed ID: 10839544
Caspases and mitochondria in c-Myc-induced apoptosis: identification of ATM as a new target of caspases.
Hotti A, Järvinen K, Siivola P, Hölttä E
Oncogene. 2000
PubMed ID: 10822387
ATM-dependent phosphorylation of nibrin in response to radiation exposure.
Gatei M, Young D, Cerosaletti KM, Desai-Mehta A, Spring K, Kozlov S, Lavin MF, Gatti RA, Concannon P, Khanna K
Nat Genet. 2000
PubMed ID: 10802669
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J
Genes Dev. 2000
PubMed ID: 10783165
Aberrant splicing of the ATM gene associated with shortening of the intronic mononucleotide tract in human colon tumor cell lines: a novel mutation target of microsatellite instability.
Ejima Y, Yang L, Sasaki MS
Int J Cancer. 2000
PubMed ID: 10738255
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway.
Lim DS, Kim ST, Xu B, Maser RS, Lin J, Petrini JH, Kastan MB
Nature. 2000
PubMed ID: 10766245
Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice.
Borghesani PR, Alt FW, Bottaro A, Davidson L, Aksoy S, Rathbun GA, Roberts TM, Swat W, Segal RA, Gu Y
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10716718
Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase.
Chan DW, Son SC, Block W, Ye R, Khanna KK, Wold MS, Douglas P, Goodarzi AA, Pelley J, Taya Y, Lavin MF, Lees-Miller SP
J Biol Chem. 2000
PubMed ID: 10713094
Mantle cell lymphoma is characterized by inactivation of the ATM gene.
Schaffner C, Idler I, Stilgenbauer S, Döhner H, Lichter P
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10706620
The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest.
Wang S, Guo M, Ouyang H, Li X, Cordon-Cardo C, Kurimasa A, Chen DJ, Fuks Z, Ling CC, Li GC
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10677503
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.
Shieh SY, Ahn J, Tamai K, Taya Y, Prives C
Genes Dev. 2000
PubMed ID: 10673501
Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system.
Chong MJ, Murray MR, Gosink EC, Russell HR, Srinivasan A, Kapsetaki M, Korsmeyer SJ, McKinnon PJ
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10639175
ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation.
Barlow C, Ribaut-Barassin C, Zwingman TA, Pope AJ, Brown KD, Owens JW, Larson D, Harrington EA, Haeberle AM, Mariani J, Eckhaus M, Herrup K, Bailly Y, Wynshaw-Boris A
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10639172
Atm deficiency causes an increased frequency of intrachromosomal homologous recombination in mice.
Bishop AJ, Barlow C, Wynshaw-Boris AJ, Schiestl RH
Cancer Res. 2000
PubMed ID: 10667593
Atm-deficient mice Purkinje cells show age-dependent defects in calcium spike bursts and calcium currents.
Chiesa N, Barlow C, Wynshaw-Boris A, Strata P, Tempia F
Neuroscience. 2000
PubMed ID: 10717437
Rescue of defective T cell development and function in Atm-/- mice by a functional TCR alpha beta transgene.
Chao C, Yang EM, Xu Y
J Immunol. 2000
PubMed ID: 10605029
Substrate specificities and identification of putative substrates of ATM kinase family members.
Kim ST, Lim DS, Canman CE, Kastan MB
J Biol Chem. 1999
PubMed ID: 10608806
Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer.
Izatt L, Greenman J, Hodgson S, Ellis D, Watts S, Scott G, Jacobs C, Liebmann R, Zvelebil MJ, Mathew C, Solomon E
Genes Chromosomes Cancer. 1999
PubMed ID: 10534763
Localization of a portion of extranuclear ATM to peroxisomes.
Watters D, Kedar P, Spring K, Bjorkman J, Chen P, Gatei M, Birrell G, Garrone B, Srinivasa P, Crane DI, Lavin MF
J Biol Chem. 1999
PubMed ID: 10567403
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.
Cortez D, Wang Y, Qin J, Elledge SJ
Science. 1999
PubMed ID: 10550055
Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase.
Kim GD, Choi YH, Dimtchev A, Jeong SJ, Dritschilo A, Jung M
J Biol Chem. 1999
PubMed ID: 10531300
Many faces of ATM: eighth international workshop on ataxia-telangiectasia.
Halazonetis TD, Shiloh Y
Biochim Biophys Acta. 1999
PubMed ID: 10528155
ATM protein synthesis patterns in sporadic breast cancer.
Kairouz R, Clarke RA, Marr PJ, Watters D, Lavin MF, Kearsley JH, Lee CS
Mol Pathol. 1999
PubMed ID: 10748873
ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia.
Lavin MF, Khanna KK
Int J Radiat Biol. 1999
PubMed ID: 10549596
Solid tissues removed from ATM homozygous deficient mice do not exhibit a mutator phenotype for second-step autosomal mutations.
Turker MS, Gage BM, Rose JA, Ponomareva ON, Tischfield JA, Stambrook PJ, Barlow C, Wynshaw-Boris A
Cancer Res. 1999
PubMed ID: 10519383
Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM.
Smith GC, Cary RB, Lakin ND, Hann BC, Teo SH, Chen DJ, Jackson SP
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10500142
ATM immunolocalization in mouse neuronal endosomes: implications for ataxia-telangiectasia.
Kuljis RO, Chen G, Lee EY, Aguila MC, Xu Y
Brain Res. 1999
PubMed ID: 10526131
Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation.
Suzuki K, Kodama S, Watanabe M
J Biol Chem. 1999
PubMed ID: 10464290
Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs.
Barlow C, Dennery PA, Shigenaga MK, Smith MA, Morrow JD, Roberts LJ, Wynshaw-Boris A, Levine RL
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10449794
Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia.
Schaffner C, Stilgenbauer S, Rappold GA, Döhner H, Lichter P
Blood. 1999
PubMed ID: 10397742
ATM: the product of the gene mutated in ataxia-telangiectasia.
Lavin MF
Int J Biochem Cell Biol. 1999
PubMed ID: 10467728
Atm inactivation results in aberrant telomere clustering during meiotic prophase.
Pandita TK, Westphal CH, Anger M, Sawant SG, Geard CR, Pandita RK, Scherthan H
Mol Cell Biol. 1999
PubMed ID: 10373558
Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity.
Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S
Oncogene. 1999
PubMed ID: 10376525
Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma.
Liao MJ, Van Dyke T
Genes Dev. 1999
PubMed ID: 10346813
Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function.
Kamijo T, van de Kamp E, Chong MJ, Zindy F, Diehl JA, Sherr CJ, McKinnon PJ
Cancer Res. 1999
PubMed ID: 10344759
Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene.
Meyn MS
Clin Genet. 1999
PubMed ID: 10422797
The association of ATR protein with mouse meiotic chromosome cores.
Moens PB, Tarsounas M, Morita T, Habu T, Rottinghaus ST, Freire R, Jackson SP, Barlow C, Wynshaw-Boris A
Chromosoma. 1999
PubMed ID: 10382071
Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl.
Chen G, Yuan SS, Liu W, Xu Y, Trujillo K, Song B, Cong F, Goff SP, Wu Y, Arlinghaus R, Baltimore D, Gasser PJ, Park MS, Sung P, Lee EY
J Biol Chem. 1999
PubMed ID: 10212258
Missense mutations at ATM gene and cancer risk.
Vorechovsky I, Luo L, Ortmann E, Steinmann D, Dörk T
Lancet. 1999
PubMed ID: 10217116
Rapid and efficient ATM mutation detection by fluorescent chemical cleavage of mismatch: identification of four novel mutations.
Izatt L, Vessey C, Hodgson SV, Solomon E
Eur J Hum Genet. 1999
PubMed ID: 10234507
Atm haploinsufficiency results in increased sensitivity to sublethal doses of ionizing radiation in mice.
Barlow C, Eckhaus MA, Schäffer AA, Wynshaw-Boris A
Nat Genet. 1999
PubMed ID: 10192382
Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction.
Liao MJ, Yin C, Barlow C, Wynshaw-Boris A, van Dyke T
Mol Cell Biol. 1999
PubMed ID: 10082576
A role for ATR in the DNA damage-induced phosphorylation of p53.
Tibbetts RS, Brumbaugh KM, Williams JM, Sarkaria JN, Cliby WA, Shieh SY, Taya Y, Prives C, Abraham RT
Genes Dev. 1999
PubMed ID: 9925639
Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia.
Stankovic T, Weber P, Stewart G, Bedenham T, Murray J, Byrd PJ, Moss PA, Taylor AM
Lancet. 1999
PubMed ID: 10023947
Poly(ADP-ribose) polymerase activity is not affected in ataxia telangiectasia cells and knockout mice.
Dantzer F, Ménissier-de Murcia J, Barlow C, Wynshaw-Boris A, de Murcia G
Carcinogenesis. 1999
PubMed ID: 9934867
ATM mutations in B-cell chronic lymphocytic leukemia.
Bullrich F, Rasio D, Kitada S, Starostik P, Kipps T, Keating M, Albitar M, Reed JC, Croce CM
Cancer Res. 1999
PubMed ID: 9892178
Characterization of ATM gene mutations in 66 ataxia telangiectasia families.
Sandoval N, Platzer M, Rosenthal A, Dörk T, Bendix R, Skawran B, Stuhrmann M, Wegner RD, Sperling K, Banin S, Shiloh Y, Baumer A, Bernthaler U, Sennefelder H, Brohm M, Weber BH, Schindler D
Hum Mol Genet. 1999
PubMed ID: 9887333
High incidence of cancer in a family segregating a mutation of the ATM gene: possible role of ATM heterozygosity in cancer.
Bay JO, Uhrhammer N, Pernin D, Presneau N, Tchirkov A, Vuillaume M, Laplace V, Grancho M, Verrelle P, Hall J, Bignon YJ
Hum Mutat. 1999
PubMed ID: 10571946
New mutations, polymorphisms, and rare variants in the ATM gene detected by a novel SSCP strategy.
Castellví-Bel S, Sheikhavandi S, Telatar M, Tai LQ, Hwang M, Wang Z, Yang Z, Cheng R, Gatti RA
Hum Mutat. 1999
PubMed ID: 10425038
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.
Matsuoka S, Huang M, Elledge SJ
Science. 1998
PubMed ID: 9836640
Strategies for mutational analysis of the large multiexon ATM gene using high-density oligonucleotide arrays.
Hacia JG, Sun B, Hunt N, Edgemon K, Mosbrook D, Robbins C, Fodor SP, Tagle DA, Collins FS
Genome Res. 1998
PubMed ID: 9872980
ATM associates with and phosphorylates p53: mapping the region of interaction.
Khanna KK, Keating KE, Kozlov S, Scott S, Gatei M, Hobson K, Taya Y, Gabrielli B, Chan D, Lees-Miller SP, Lavin MF
Nat Genet. 1998
PubMed ID: 9843217
Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111).
Heesom KJ, Avison MB, Diggle TA, Denton RM
Biochem J. 1998
PubMed ID: 9806882
Selective loss of dopaminergic nigro-striatal neurons in brains of Atm-deficient mice.
Eilam R, Peter Y, Elson A, Rotman G, Shiloh Y, Groner Y, Segal M
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9770541
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.
Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE, Abraham RT
Cancer Res. 1998
PubMed ID: 9766667
The complexity of p53 modulation: emerging patterns from divergent signals.
Giaccia AJ, Kastan MB
Genes Dev. 1998
PubMed ID: 9765199
Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I.
Barlow C, Liyanage M, Moens PB, Tarsounas M, Nagashima K, Brown K, Rottinghaus S, Jackson SP, Tagle D, Ried T, Wynshaw-Boris A
Development. 1998
PubMed ID: 9735362
Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia.
Soares HD, Morgan JI, McKinnon PJ
Neuroscience. 1998
PubMed ID: 9697112
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.
Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD
Science. 1998
PubMed ID: 9733515
Enhanced phosphorylation of p53 by ATM in response to DNA damage.
Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y, Ziv Y
Science. 1998
PubMed ID: 9733514
Mouse cdc21 only 0.5 kb upstream from dna-pkcs in a head-to-head organization: an implication of co-evolution of ATM family members and cell cycle regulating genes.
Saito T, Matsuda Y, Ishii H, Watanabe F, Mori M, Hayashi A, Araki R, Fujimori A, Fukumura R, Morimyo M, Tatsumi K, Hori T, Abe M
Mamm Genome. 1998
PubMed ID: 9716665
ATM binds to beta-adaptin in cytoplasmic vesicles.
Lim DS, Kirsch DG, Canman CE, Ahn JH, Ziv Y, Newman LS, Darnell RB, Shiloh Y, Kastan MB
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9707615
Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice.
Xu Y, Yang EM, Brugarolas J, Jacks T, Baltimore D
Mol Cell Biol. 1998
PubMed ID: 9632822
Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system.
Herzog KH, Chong MJ, Kapsetaki M, Morgan JI, McKinnon PJ
Science. 1998
PubMed ID: 9582124
Inactivation of the ATM gene in T-cell prolymphocytic leukemias.
Stoppa-Lyonnet D, Soulier J, Laugé A, Dastot H, Garand R, Sigaux F, Stern MH
Blood. 1998
PubMed ID: 9573030
Identical mutation in 55% of the ATM alleles in 11 Norwegian AT families: evidence for a founder effect.
Laake K, Telatar M, Geitvik GA, Hansen RO, Heiberg A, Andresen AM, Gatti R, Børresen-Dale AL
Eur J Hum Genet. 1998
PubMed ID: 9781027
Mutations of the ATM gene detected in Japanese ataxia-telangiectasia patients: possible preponderance of the two founder mutations 4612del165 and 7883del5.
Ejima Y, Sasaki MS
Hum Genet. 1998
PubMed ID: 9600235
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.
Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM
J Biol Chem. 1998
PubMed ID: 9488723
Genotype-phenotype relationships in ataxia-telangiectasia and variants.
Gilad S, Chessa L, Khosravi R, Russell P, Galanty Y, Piane M, Gatti RA, Jorgensen TJ, Shiloh Y, Bar-Shira A
Am J Hum Genet. 1998
PubMed ID: 9497252
ATM is usually rearranged in T-cell prolymphocytic leukaemia.
Yuille MA, Coignet LJ, Abraham SM, Yaqub F, Luo L, Matutes E, Brito-Babapulle V, Vorechovský I, Dyer MJ, Catovsky D
Oncogene. 1998
PubMed ID: 9488043
A double missense mutation in the ATM gene of a Dutch family with ataxia telangiectasia.
van Belzen MJ, Hiel JA, Weemaes CM, Gabreëls FJ, van Engelen BG, Smeets DF, van den Heuvel LP
Hum Genet. 1998
PubMed ID: 9521587
ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer.
Stankovic T, Kidd AM, Sutcliffe A, McGuire GM, Robinson P, Weber P, Bedenham T, Bradwell AR, Easton DF, Lennox GG, Haites N, Byrd PJ, Taylor AM
Am J Hum Genet. 1998
PubMed ID: 9463314
Ataxia-telangiectasia without immunodeficiency: novel point mutations within and adjacent to the phosphatidylinositol 3-kinase-like domain.
Toyoshima M, Hara T, Zhang H, Yamamoto T, Akaboshi S, Nanba E, Ohno K, Hori N, Sato K, Takeshita K
Am J Med Genet. 1998
PubMed ID: 9450874
Ataxia-telangiectasia in the Japanese population: identification of R1917X, W2491R, R2909G, IVS33+2T-->A, and 7883del5, the latter two being relatively common mutations.
Fukao T, Song XQ, Yoshida T, Tashita H, Kaneko H, Teramoto T, Inoue R, Katamura K, Mayumi M, Hiratani M, Taniguchi N, Arai J, Wakiguchi H, Bar-Shira A, Shiloh Y, Kondo N
Hum Mutat. 1998
PubMed ID: 9792410
ATM germline mutations in classical ataxia-telangiectasia patients in the Dutch population.
Broeks A, de Klein A, Floore AN, Muijtjens M, Kleijer WJ, Jaspers NG, van 't Veer LJ
Hum Mutat. 1998
PubMed ID: 9792409
ATM mutations in patients with ataxia telangiectasia screened by a hierarchical strategy.
Sasaki T, Tian H, Kukita Y, Inazuka M, Tahira T, Imai T, Yamauchi M, Saito T, Hori T, Hashimoto-Tamaoki T, Komatsu K, Nikaido O, Hayashi K
Hum Mutat. 1998
PubMed ID: 9711876
Ataxia-telangiectasia: identification and detection of founder-effect mutations in the ATM gene in ethnic populations.
Telatar M, Teraoka S, Wang Z, Chun HH, Liang T, Castellvi-Bel S, Udar N, Borresen-Dale AL, Chessa L, Bernatowska-Matuszkiewicz E, Porras O, Watanabe M, Junker A, Concannon P, Gatti RA
Am J Hum Genet. 1998
PubMed ID: 9443866
Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice.
Wang YA, Elson A, Leder P
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9405657
Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles.
Barlow C, Liyanage M, Moens PB, Deng CX, Ried T, Wynshaw-Boris A
Nat Genet. 1997
PubMed ID: 9398851
Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways.
Barlow C, Brown KD, Deng CX, Tagle DA, Wynshaw-Boris A
Nat Genet. 1997
PubMed ID: 9398849
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes.
Flaggs G, Plug AW, Dunks KM, Mundt KE, Ford JC, Quiggle MR, Taylor EM, Westphal CH, Ashley T, Hoekstra MF, Carr AM
Curr Biol. 1997
PubMed ID: 9382850
Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia-telangiectasia.
Kuljis RO, Xu Y, Aguila MC, Baltimore D
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9356511
Biallelic mutations in the ATM gene in T-prolymphocytic leukemia.
Stilgenbauer S, Schaffner C, Litterst A, Liebisch P, Gilad S, Bar-Shira A, James MR, Lichter P, Döhner H
Nat Med. 1997
PubMed ID: 9334731
Phenotypic correction of ataxia-telangiectasia cellular defect by exogenously introduced human or mouse subchromosomal fragments.
Ejima Y, Sasaki MS
Somat Cell Mol Genet. 1997
PubMed ID: 9546077
Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia.
Vorechovský I, Luo L, Dyer MJ, Catovsky D, Amlot PL, Yaxley JC, Foroni L, Hammarström L, Webster AD, Yuille MA
Nat Genet. 1997
PubMed ID: 9288106
atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity.
Westphal CH, Rowan S, Schmaltz C, Elson A, Fisher DE, Leder P
Nat Genet. 1997
PubMed ID: 9241281
Ataxia-telangiectasia locus: sequence analysis of 184 kb of human genomic DNA containing the entire ATM gene.
Platzer M, Rotman G, Bauer D, Uziel T, Savitsky K, Bar-Shira A, Gilad S, Shiloh Y, Rosenthal A
Genome Res. 1997
PubMed ID: 9199932
Interaction between ATM protein and c-Abl in response to DNA damage.
Shafman T, Khanna KK, Kedar P, Spring K, Kozlov S, Yen T, Hobson K, Gatei M, Zhang N, Watters D, Egerton M, Shiloh Y, Kharbanda S, Kufe D, Lavin MF
Nature. 1997
PubMed ID: 9168117
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation.
Baskaran R, Wood LD, Whitaker LL, Canman CE, Morgan SE, Xu Y, Barlow C, Baltimore D, Wynshaw-Boris A, Kastan MB, Wang JY
Nature. 1997
PubMed ID: 9168116
Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints.
Westphal CH, Schmaltz C, Rowan S, Elson A, Fisher DE, Leder P
Cancer Res. 1997
PubMed ID: 9135004
Ataxia-telangiectasia: structural diversity of untranslated sequences suggests complex post-transcriptional regulation of ATM gene expression.
Savitsky K, Platzer M, Uziel T, Gilad S, Sartiel A, Rosenthal A, Elroy-Stein O, Shiloh Y, Rotman G
Nucleic Acids Res. 1997
PubMed ID: 9108147
Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms.
Watters D, Khanna KK, Beamish H, Birrell G, Spring K, Kedar P, Gatei M, Stenzel D, Hobson K, Kozlov S, Zhang N, Farrell A, Ramsay J, Gatti R, Lavin M
Oncogene. 1997
PubMed ID: 9150358
The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage.
Brown KD, Ziv Y, Sadanandan SN, Chessa L, Collins FS, Shiloh Y, Tagle DA
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9050866
ATM gene product phosphorylates I kappa B-alpha.
Jung M, Kondratyev A, Lee SA, Dimtchev A, Dritschilo A
Cancer Res. 1997
PubMed ID: 8988033
The product of the ATM gene is a 370-kDa nuclear phosphoprotein.
Chen G, Lee EYHP
J Biol Chem. 1996
PubMed ID: 8969240
Analysis of the ATM protein in wild-type and ataxia telangiectasia cells.
Lakin ND, Weber P, Stankovic T, Rottinghaus ST, Taylor AM, Jackson SP
Oncogene. 1996
PubMed ID: 9000145
Ataxia-telangiectasia: founder effect among north African Jews.
Gilad S, Bar-Shira A, Harnik R, Shkedy D, Ziv Y, Khosravi R, Brown K, Vanagaite L, Xu G, Frydman M, Lavin MF, Hill D, Tagle DA, Shiloh Y
Hum Mol Genet. 1996
PubMed ID: 8968760
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
Elson A, Wang Y, Daugherty CJ, Morton CC, Zhou F, Campos-Torres J, Leder P
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8917548
The defect in the AT-like hamster cell mutants is complemented by mouse chromosome 9 but not by any of the human chromosomes.
Jongmans W, Verhaegh GW, Jaspers NG, Demant P, Natarajan AT, Shiloh Y, Oshimura M, Stanbridge EJ, Athwal RS, Cuthbert AP, Newbold RF, Lohman PH, Zdzienicka MZ
Mutat Res. 1996
PubMed ID: 8879275
The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.
Keegan KS, Holtzman DA, Plug AW, Christenson ER, Brainerd EE, Flaggs G, Bentley NJ, Taylor EM, Meyn MS, Moss SB, Carr AM, Ashley T, Hoekstra MF
Genes Dev. 1996
PubMed ID: 8843195
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.
Xu Y, Ashley T, Brainerd EE, Bronson RT, Meyn MS, Baltimore D
Genes Dev. 1996
PubMed ID: 8843194
Dual roles of ATM in the cellular response to radiation and in cell growth control.
Xu Y, Baltimore D
Genes Dev. 1996
PubMed ID: 8843193
Strange bedfellows in even stranger places: the role of ATM in meiotic cells, lymphocytes, tumors, and its functional links to p53.
Hawley RS, Friend SH
Genes Dev. 1996
PubMed ID: 8843191
A high frequency of distinct ATM gene mutations in ataxia-telangiectasia.
Wright J, Teraoka S, Onengut S, Tolun A, Gatti RA, Ochs HD, Concannon P
Am J Hum Genet. 1996
PubMed ID: 8808599
ATM mutations in cancer families.
Vorechovský I, Luo L, Lindblom A, Negrini M, Webster AD, Croce CM, Hammarström L
Cancer Res. 1996
PubMed ID: 8797579
Mutations associated with variant phenotypes in ataxia-telangiectasia.
McConville CM, Stankovic T, Byrd PJ, McGuire GM, Yao QY, Lennox GG, Taylor MR
Am J Hum Genet. 1996
PubMed ID: 8755918
New mutations in the ataxia telangiectasia gene.
Baumer A, Bernthaler U, Wolz W, Hoehn H, Schindler D
Hum Genet. 1996
PubMed ID: 8698354
Atm-deficient mice: a paradigm of ataxia telangiectasia.
Barlow C, Hirotsune S, Paylor R, Liyanage M, Eckhaus M, Collins F, Shiloh Y, Crawley JN, Ried T, Tagle D, Wynshaw-Boris A
Cell. 1996
PubMed ID: 8689683
Assignment of the mouse ataxia-telangiectasia gene (Atm) to mouse chromosome 9.
Xia Y, Welch CL, Warden CH, Lange E, Fukao T, Lusis AJ, Gatti RA
Mamm Genome. 1996
PubMed ID: 8672141
Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene.
Pecker I, Avraham KB, Gilbert DJ, Savitsky K, Rotman G, Harnik R, Fukao T, Schröck E, Hirotsune S, Tagle DA, Collins FS, Wynshaw-Boris A, Ried T, Copeland NG, Jenkins NA, Shiloh Y, Ziv Y
Genomics. 1996
PubMed ID: 8661102
Comparative genome mapping of the ataxia-telangiectasia region in mouse, rat, and Syrian hamster.
Matsuda Y, Imai T, Shiomi T, Saito T, Yamauchi M, Fukao T, Akao Y, Seki N, Ito H, Hori TA
Genomics. 1996
PubMed ID: 8786135
The ATM gene and susceptibility to breast cancer: analysis of 38 breast tumors reveals no evidence for mutation.
Vorechovský I, Rasio D, Luo L, Monaco C, Hammarström L, Webster AD, Zaloudik J, Barbanti-Brodani G, James M, Russo G
Cancer Res. 1996
PubMed ID: 8665503
Predominance of null mutations in ataxia-telangiectasia.
Gilad S, Khosravi R, Shkedy D, Uziel T, Ziv Y, Savitsky K, Rotman G, Smith S, Chessa L, Jorgensen TJ, Harnik R, Frydman M, Sanal O, Portnoi S, Goldwicz Z, Jaspers NG, Gatti RA, Lenoir G, Lavin MF, Tatsumi K, Wegner RD, Shiloh Y, Bar-Shira A
Hum Mol Genet. 1996
PubMed ID: 8845835
Exon-scanning mutation analysis of the ATM gene in patients with ataxia-telangiectasia.
Vorechovský I, Luo L, Prudente S, Chessa L, Russo G, Kanariou M, James M, Negrini M, Webster AD, Hammarström L
Eur J Hum Genet. 1996
PubMed ID: 9043869
Mutations revealed by sequencing the 5' half of the gene for ataxia telangiectasia.
Byrd PJ, McConville CM, Cooper P, Parkhill J, Stankovic T, McGuire GM, Thick JA, Taylor AM
Hum Mol Genet. 1996
PubMed ID: 8789452
Genomic organization of the ATM locus involved in ataxia-telangiectasia.
Rasio D, Negrini M, Croce CM
Cancer Res. 1995
PubMed ID: 8521392
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species.
Savitsky K, Sfez S, Tagle DA, Ziv Y, Sartiel A, Collins FS, Shiloh Y, Rotman G
Hum Mol Genet. 1995
PubMed ID: 8589678
The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.
Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7644499
A single ataxia telangiectasia gene with a product similar to PI-3 kinase.
Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, Tagle DA, Smith S, Uziel T, Sfez S, Ashkenazi M, Pecker I, Frydman M, Harnik R, Patanjali SR, Simmons A, Clines GA, Sartiel A, Gatti RA, Chessa L, Sanal O, Lavin MF, Jaspers NG, Taylor AM, Arlett CF, Miki T, Weissman SM, Lovett M, Collins FS, Shiloh Y
Science. 1995
PubMed ID: 7792600
Del(12)(p11.21p12.2) associated with an asphyxiating thoracic dystrophy or chondroectodermal dysplasia-like syndrome.
Nagai T, Nishimura G, Kato R, Hasegawa T, Ohashi H, Fukushima Y
Am J Med Genet. 1995
PubMed ID: 7702088
Comparison of collagen propeptides as growth markers in children with inflammatory bowel disease.
Hyams JS, Treem WR, Carey DE, Wyzga N, Eddy E, Goldberg BD, Moore RE
Gastroenterology. 1991
PubMed ID: 2001833
ATFresno: a phenotype linking ataxia-telangiectasia with the Nijmegen breakage syndrome.
Curry CJ, O'Lague P, Tsai J, Hutchison HT, Jaspers NG, Wara D, Gatti RA, Hutchinson HT
Am J Hum Genet. 1989
PubMed ID: 2491181
Localization of an ataxia-telangiectasia gene to chromosome 11q22-23.
Gatti RA, Berkel I, Boder E, Braedt G, Charmley P, Concannon P, Ersoy F, Foroud T, Jaspers NG, Lange K
Nature. 1988
PubMed ID: 3200306
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Model Organism Phenotype Links from MGI Top Help

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External Links Top Help

	Human	Mouse	Rat
Entrez Gene	472	11920	300711
EnsEMBL Gene(s)	ENSG00000149311 LRG_135	ENSMUSG00000034218	ENSRNOG00000029773
Unigene	Hs.367437	Mm.5088	Rn.214048
Homologene	ATM	Atm	Atm
OMIM	607585	N/A	N/A
GeneCards	ATM	N/A	N/A
Beta Cell Genomics	DT.100750015 DT.101977439 DT.102832095 DT.120760397 DT.451837 DT.91916232 DT.97841685 DT.99957611 DT.99971554	DT.101722243 DT.110601795 DT.87068578 DT.87072152	N/A
Reactome	Q13315	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	472	11920	300711

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
ATM	CDK2	Reactome	predicted
ATM	CDK4	Reactome	predicted	17981954 8929543 16123081 10438626 9311981 9450758 10562567 18256600 15164066 15304223 10728666 10029069 10734115 17977839 17541404 9008167 18535008 9826763 20062530
ATM	KAT5	HPRD	empirical	16141325
ATM	TOPBP1	HPRD	empirical	11756551
ATM	CHEK1	HPRD	empirical	11390642 11252893
ATM	DMC1	Reactome	predicted	17981954 8929543 16123081 10438626 9311981 9450758 10562567 18256600 15164066 17541404 9008167 18535008 9826763 20062530
ATM	CHEK2	HPRD	empirical	11901158 12242661 10973490 12493754 16794575 12024051
ATM	CREB1	HPRD	empirical	16293623 15073328
ATM	AP1B1	HPRD, MIPS	empirical	9707615
ATM	AP2B1	HPRD	empirical	9707615
ATM	DDB1	IntAct, BioGRID	empirical	20360068
ATM	E2F1	HPRD	empirical	11459832
ATM	EIF4EBP1	HPRD	empirical	9806882 11146653 12588975
ATM	ALB	IntAct	empirical	15174051
ATM	FANCD2	HPRD	empirical	12086603
ATM	ATMIN	MINT	empirical	17525732
ATM	ABL1	HPRD, IntAct	empirical	9168117 9168116 11375976
ATM	TIPARP	HPRD	empirical	11238919
ATM	AATF	HPRD, IntAct	empirical	17157788
ATM	SFN	IntAct	empirical	20843328
ATM	H2AFX	HPRD, MINT, BioGRID	empirical	9488723 11893489 11571274 16858402
ATM	LMNB1	IntAct, BioGRID	empirical	20360068
ATM	MDM2	HPRD	empirical	11331603
ATM	MDM4	HPRD	empirical	15788536 16163388
ATM	MRE11A	HPRD	empirical	10608806
ATM	MYC	IntAct	empirical	21150319
ATM	NBN	HPRD	empirical	10839544 11252893 10839545 10608806
ATM	ATM	HPRD, IntAct	empirical	14519663 12556884 10608806 16858402 16906133 20360068
ATM	DCAF8	IntAct, BioGRID	empirical	20360068
ATM	PPP1CA	IntAct	empirical	17274640
ATM	PPP1CC	IntAct	empirical	17274640
ATM	DCAF6	IntAct, BioGRID	empirical	20360068
ATM	PRKDC	HPRD	empirical	10464290
ATM	PEX5	HPRD	empirical	10567403
ATM	RAD9A	HPRD	empirical	12709442 11278446
ATM	RAD17	HPRD	empirical	11418864 10608806
ATM	RAD51	HPRD, Reactome	empirical	10212258 17981954 8929543 16123081 10438626 9311981 9450758 10562567 18256600 15164066 17541404 9008167 18535008 9826763 20062530
ATM	RBBP8	HPRD	empirical	10910365 11689934
ATM	RHEB	HPRD	empirical	15854902
ATM	BLM	Reactome	predicted	15304223 16123081 10728666 10029069 10734115 17977839
ATM	DCLRE1C	HPRD	empirical	15456891
ATM	BRCA1	HPRD, Reactome	empirical	10550055 10866324 11114888 17541404 9008167 17981954 16123081 9311981 18535008 9826763 10562567 20062530 15164066
ATM	BRCA2	Reactome	predicted	17981954 8929543 16123081 10438626 9311981 9450758 10562567 18256600 15164066 15304223 10728666 10029069 10734115 17977839 17541404 9008167 18535008 9826763 20062530
ATM	STK11	HPRD	empirical	11853558 12234250
ATM	TERF1	HPRD, IntAct	empirical	11375976 15314656
ATM	TOP3A	Reactome	predicted	15304223 16123081 10728666 10029069 10734115 17977839
ATM	TP53	HPRD, MINT, IntAct, BioGRID	empirical	9765199 11551930 11709713 10673501 11875057 16858402 17157788 9843217 10864201 18162465
ATM	TP53BP1	HPRD	empirical	12697768
ATM	VHL	IntAct	empirical	17353931
ATM	WRN	HPRD	empirical	10608806 11252893 10839545
ATM	XPA	HPRD	empirical	16540648
ATM	XRCC5	HPRD	empirical	15758953
ATM	OBFC2B	IntAct	empirical	18449195
ATM	TTI2	IntAct	empirical	20810650
ATM	AP3B2	HPRD, MIPS	empirical	9707615
ATM	SMC1A	HPRD, IntAct	empirical	11877377
ATM	ATRIP	HPRD	empirical	15758953
ATM	CUL4A	IntAct, BioGRID	empirical	20360068
ATM	IKBKG	MINT	empirical	18583959
ATM	RUVBL1	IntAct	empirical	20371770
ATM	RNF8	IntAct	empirical	18001825
ATM	EEF1E1	HPRD	empirical	15680327
ATM	MDC1	HPRD, IntAct	empirical	12607005
ATM	TTI1	IntAct	empirical	20810650
ATM	TELO2	IntAct	empirical	18160036 20801936