T1DBase - A Bioinformatics Resource for Type 1 Diabetes Researchers

Gene Description:

microtubule-associated protein 1 light chain 3 gamma

Synonyms:

ATG8J, MAP1LC3C, LC3C

Orthologs:

Human MAP1LC3C (protein-coding)

Sources

(Human) GRCh37 - chr1:242158792..242162385 (3.59 kb) View in Genome Browser

HaemAtlas Expression Table for MAP1LC3C:

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
			no data		no data	no data	no data	no data	no data	no data	no data	no data

Expression Legend

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Table for MAP1LC3C:

The MAP1LC3C interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
MAP1LC3C	PDCD6IP	IntAct	empirical	20562859
MAP1LC3C	SF3A1	IntAct, BioGRID	empirical	20562859
MAP1LC3C	ATG7	IntAct, BioGRID	empirical	20562859
MAP1LC3C	RASSF1	IntAct	empirical	20562859
MAP1LC3C	GABARAP	IntAct, BioGRID	empirical	20562859
MAP1LC3C	GABARAPL2	IntAct, BioGRID	empirical	20562859
MAP1LC3C	NCOA7	IntAct	empirical	20562859
MAP1LC3C	DYX1C1	IntAct	empirical	20562859
MAP1LC3C	FNBP1	IntAct	empirical	20562859
MAP1LC3C	TBC1D2B	IntAct	empirical	20562859
MAP1LC3C	ATG2A	IntAct	empirical	20562859
MAP1LC3C	ATG4B	IntAct	empirical	20562859
MAP1LC3C	RABGAP1	IntAct	empirical	20562859
MAP1LC3C	GBAS	IntAct	empirical	20562859
MAP1LC3C	GYS1	IntAct	empirical	20562859
MAP1LC3C	HADHB	IntAct	empirical	20562859
MAP1LC3C	PIK3R4	BioGRID	empirical	20562859
MAP1LC3C	HNRNPA2B1	IntAct	empirical	20562859
MAP1LC3C	IPO5	IntAct	empirical	20562859
MAP1LC3C	NBR1	IntAct	empirical	19250911 20562859
MAP1LC3C	MAP1LC3C	IntAct	empirical	20562859
MAP1LC3C	NEDD4	IntAct	empirical	20562859
MAP1LC3C	ANKFY1	IntAct	empirical	20562859
MAP1LC3C	PIK3C3	IntAct, BioGRID	empirical	20562859
MAP1LC3C	ATG16L1	IntAct, BioGRID	empirical	20562859
MAP1LC3C	PRKAR1A	IntAct	empirical	20562859
MAP1LC3C	C12orf44	IntAct	empirical	20562859
MAP1LC3C	RNF123	IntAct	empirical	20562859
MAP1LC3C	ATG3	IntAct, BioGRID	empirical	20562859
MAP1LC3C	TBC1D15	IntAct	empirical	20562859
MAP1LC3C	STK3	IntAct	empirical	20562859
MAP1LC3C	STK4	IntAct	empirical	20562859
MAP1LC3C	TFCP2	IntAct, BioGRID	empirical	20562859
MAP1LC3C	FYCO1	IntAct	empirical	20562859
MAP1LC3C	UBA5	IntAct	empirical	20562859
MAP1LC3C	USP11	IntAct, BioGRID	empirical	20562859
MAP1LC3C	RASSF5	IntAct	empirical	20562859
MAP1LC3C	ATG10	IntAct	empirical	20562859
MAP1LC3C	KBTBD7	IntAct	empirical	20562859
MAP1LC3C	ULK1	IntAct	empirical	20562859
MAP1LC3C	NSMAF	IntAct	empirical	20562859
MAP1LC3C	SQSTM1	IntAct	empirical	19250911 20562859
MAP1LC3C	KBTBD6	IntAct	empirical	20562859
MAP1LC3C	LACRT	IntAct	empirical	20562859
MAP1LC3C	NEK9	IntAct	empirical	20562859
MAP1LC3C	ATG5	IntAct, BioGRID	empirical	20562859
MAP1LC3C	APOBEC3B	IntAct	empirical	20562859
MAP1LC3C	FNIP1	IntAct	empirical	20562859
MAP1LC3C	SAFB2	IntAct	empirical	20562859
MAP1LC3C	CLINT1	IntAct	empirical	20562859
MAP1LC3C	ATG13	IntAct	empirical	20562859
MAP1LC3C	RB1CC1	IntAct, BioGRID	empirical	20562859
MAP1LC3C	TECPR2	IntAct	empirical	20562859

View all

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 10

Publications: 10

Network organization of the human autophagy system.
Behrends C, Sowa ME, Gygi SP, Harper JW
Nature. 2010
PubMed ID: 20562859
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
Kirkin V, Lamark T, Sou YS, Bjørkøy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Øvervatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T
Mol Cell. 2009
PubMed ID: 19250911
The DNA sequence and biological annotation of human chromosome 1.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E
Nature. 2006
PubMed ID: 16710414
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates.
Tanida I, Sou YS, Ezaki J, Minematsu-Ikeguchi N, Ueno T, Kominami E
J Biol Chem. 2004
PubMed ID: 15187094
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW
Nat Biotechnol. 2004
PubMed ID: 15146197
Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B.
He H, Dang Y, Dai F, Guo Z, Wu J, She X, Pei Y, Chen Y, Ling W, Wu C, Zhao S, Liu JO, Yu L
J Biol Chem. 2003
PubMed ID: 12740394
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
The cleavage of host cell proteins by HIV-1 protease.
Snásel J, Pichová I
Folia Biol (Praha). 1996
PubMed ID: 8997639
Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases.
Wallin M, Deinum J, Goobar L, Danielson UH
J Gen Virol. 1990
PubMed ID: 2212989

No mouse phenotype links available for this gene.

	Human	Mouse	Rat
Entrez Gene	440738	N/A	N/A
EnsEMBL Gene(s)	ENSG00000197769	N/A	N/A
Unigene	Hs.534971	N/A	N/A
Homologene	MAP1LC3C	N/A	N/A
OMIM	609605	N/A	N/A
GeneCards	MAP1LC3C	N/A	N/A
Beta Cell Genomics	DT.95149060	N/A	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	440738	N/A	N/A

Relevant resources: