MRE11A

Summary Top Help

Gene Description:

MRE11 meiotic recombination 11 homolog A (S. cerevisiae); meiotic recombination 11 homolog A (S. cerevisiae)

Synonyms:

ATLD, Mre11b, Mre11, MRE11B, MRE11, MRE11A, HNGS1, Mre11a

Orthologs:

Human MRE11A (protein-coding), Mouse Mre11a (protein-coding), Rat Mre11a (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:94150466..94227074 (76.61 kb) View in Genome Browser

(Mouse) NCBIM37 - chr9:14589098..14641567 (52.47 kb) View in Genome Browser

(Rat) RGSC3.4 - chr8:11588409..11632483 (447 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for MRE11A:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for MRE11A:

The MRE11A interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
MRE11A	RAD50	HPRD, MINT, IntAct, Reactome, Sanger Interaction Map	empirical	8756642 10888888 16163361 19197236 18854157 15345047
MRE11A	EP300	HPRD	empirical	16051665
MRE11A	FANCD2	HPRD	empirical	12447395
MRE11A	SIRT1	IntAct	empirical	17612497
MRE11A	XRCC6	HPRD	empirical	10508516
MRE11A	H2AFX	HPRD, IntAct	empirical	12419185
MRE11A	LIG1	HPRD	empirical	8530104
MRE11A	MRE11A	IntAct	empirical	18854157
MRE11A	NBN	HPRD, IntAct, BioGRID, Reactome	empirical	9705271 11238951 10426999 18854157 12419185 17612497 21884979
MRE11A	ATM	HPRD	empirical	10608806
MRE11A	NEK1	HPRD, IntAct	empirical	14690447
MRE11A	PRKDC	BioGRID	empirical	19015239
MRE11A	AICDA	IntAct	empirical	21186367
MRE11A	DCLRE1C	HPRD	empirical	15456891
MRE11A	DYNLT1	Sanger Interaction Map	predicted	15345047
MRE11A	USP11	IntAct	empirical	19615732
MRE11A	CCNE1	HPRD, IntAct	empirical	12607005
MRE11A	MDC1	IntAct	empirical	12607005

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 2

Biocarta: 2

Reactome: 7

NCI-Nature Pathway Interaction Database: 5

Gene Ontology: 38

Publications from PubMed Top Help

Publications: 218

Involvement of MRE11A and XPA gene polymorphisms in the modulation of DNA double-strand break repair activity: a genotype-phenotype correlation study.
Ricceri F, Porcedda P, Allione A, Turinetto V, Polidoro S, Guarrera S, Rosa F, Voglino F, Pezzotti A, Minieri V, Accomasso L, Cibrario Rocchietti E, Orlando L, Giachino C, Matullo G
DNA Repair (Amst). 2011
PubMed ID: 21880556
Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway.
Della-Maria J, Zhou Y, Tsai MS, Kuhnlein J, Carney JP, Paull TT, Tomkinson AE
J Biol Chem. 2011
PubMed ID: 21816818
NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.
Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takezawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, Komatsu K
Mol Cell. 2011
PubMed ID: 21884979
Identification of Mre11 as a target for heat radiosensitization.
Dynlacht JR, Batuello CN, Lopez JT, Kim KK, Turchi JJ
Radiat Res. 2011
PubMed ID: 21699368
Mre11 is expressed in mammalian mitochondria where it binds to mitochondrial DNA.
Dmitrieva NI, Malide D, Burg MB
Am J Physiol Regul Integr Comp Physiol. 2011
PubMed ID: 21677273
Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.
Schlacher K, Christ N, Siaud N, Egashira A, Wu H, Jasin M
Cell. 2011
PubMed ID: 21565612
MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers.
Vilar E, Bartnik CM, Stenzel SL, Raskin L, Ahn J, Moreno V, Mukherjee B, Iniesta MD, Morgan MA, Rennert G, Gruber SB
Cancer Res. 2011
PubMed ID: 21300766
Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.
Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, Ogi T, Tahara H, Oku S, Hiramoto A, Shiiki T, Fujisawa Y, Ohashi H, Sakemi Y, Matsuura S
DNA Repair (Amst). 2011
PubMed ID: 21227757
PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation.
Deng R, Tang J, Ma JG, Chen SP, Xia LP, Zhou WJ, Li DD, Feng GK, Zeng YX, Zhu XF
Oncogene. 2011
PubMed ID: 20956948
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.
Nimonkar AV, Genschel J, Kinoshita E, Polaczek P, Campbell JL, Wyman C, Modrich P, Kowalczykowski SC
Genes Dev. 2011
PubMed ID: 21325134
Clinical and molecular characterization of ataxia with oculomotor apraxia patients in Saudi Arabia.
Bohlega SA, Shinwari JM, Al Sharif LJ, Khalil DS, Alkhairallah TS, Al Tassan NA
BMC Med Genet. 2011
PubMed ID: 21324166
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy cantonese.
Shen GP, Pan QH, Hong MH, Qin HD, Xu YF, Chen LZ, Feng QS, Jorgensen TJ, Shugart YY, Zeng YX, Jia WH
Int J Cancer. 2010
PubMed ID: 21077165
Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies.
Shen M, Menashe I, Morton LM, Zhang Y, Armstrong B, Wang SS, Lan Q, Hartge P, Purdue MP, Cerhan JR, Grulich A, Cozen W, Yeager M, Holford TR, Vajdic CM, Davis S, Leaderer B, Kricker A, Severson RK, Zahm SH, Chatterjee N, Rothman N, Chanock SJ, Zheng T
Br J Haematol. 2010
PubMed ID: 20813000
Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.
Liu Y, Shete S, Wang LE, El-Zein R, Etzel CJ, Liang FW, Armstrong G, Tsavachidis S, Gilbert MR, Aldape KD, Xing J, Wu X, Wei Q, Bondy ML
Carcinogenesis. 2010
PubMed ID: 20610542
MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer.
Choudhury A, Nelson LD, Teo MT, Chilka S, Bhattarai S, Johnston CF, Elliott F, Lowery J, Taylor CF, Churchman M, Bentley J, Knowles MA, Harnden P, Bristow RG, Bishop DT, Kiltie AE
Cancer Res. 2010
PubMed ID: 20843819
Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells.
Kavitha CV, Choudhary B, Raghavan SC, Muniyappa K
Biochem Biophys Res Commun. 2010
PubMed ID: 20682289
ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining.
Rahal EA, Henricksen LA, Li Y, Williams RS, Tainer JA, Dixon K
Cell Cycle. 2010
PubMed ID: 20647759
Variation within DNA repair pathway genes and risk of multiple sclerosis.
Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF, International Multiple Sclerosis Genetics Consortium
Am J Epidemiol. 2010
PubMed ID: 20522537
Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.
Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J
Breast Cancer Res Treat. 2010
PubMed ID: 20496165
A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin.
Hari FJ, Spycher C, Jungmichel S, Pavic L, Stucki M
EMBO Rep. 2010
PubMed ID: 20224574
Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.
Loizidou MA, Cariolou MA, Neuhausen SL, Newbold RF, Bashiardes E, Marcou Y, Michael T, Daniel M, Kakouri E, Papadopoulos P, Malas S, Hadjisavvas A, Kyriacou K
Breast Cancer Res Treat. 2010
PubMed ID: 19714462
Autopsy study of cerebellar degeneration in siblings with ataxia-telangiectasia-like disorder.
Oba D, Hayashi M, Minamitani M, Hamano S, Uchisaka N, Kikuchi A, Kishimoto H, Takagi M, Morio T, Mizutani S
Acta Neuropathol. 2010
PubMed ID: 20087742
MRN and the race to the break.
Rupnik A, Lowndes NF, Grenon M
Chromosoma. 2010
PubMed ID: 19862546
Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex.
Chailleux C, Tyteca S, Papin C, Boudsocq F, Puget N, Courilleau C, Grigoriev M, Canitrot Y, Trouche D
Biochem J. 2010
PubMed ID: 20070254
53BP1 promotes ATM activity through direct interactions with the MRN complex.
Lee JH, Goodarzi AA, Jeggo PA, Paull TT
EMBO J. 2010
PubMed ID: 20010693
Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.
Rotolo JA, Mesicek J, Maj J, Truman JP, Haimovitz-Friedman A, Kolesnick R, Fuks Z
Cancer Res. 2010
PubMed ID: 20086180
MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.
Yuan J, Chen J
J Biol Chem. 2010
PubMed ID: 19910469
Analysis of the expression of human tumor antigens in ovarian cancer tissues.
Ali-Fehmi R, Chatterjee M, Ionan A, Levin NK, Arabi H, Bandyopadhyay S, Shah JP, Bryant CS, Hewitt SM, O'Rand MG, Alekseev OM, Morris R, Munkarah A, Abrams J, Tainsky MA
Cancer Biomark. 2010
PubMed ID: 20164540
Dicer is required for Sertoli cell function and survival.
Kim GJ, Georg I, Scherthan H, Merkenschlager M, Guillou F, Scherer G, Barrionuevo F
Int J Dev Biol. 2010
PubMed ID: 19876815
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q
Occup Environ Med. 2009
PubMed ID: 19773279
Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women.
Kontorovich T, Levy A, Korostishevsky M, Nir U, Friedman E
Int J Cancer. 2009
PubMed ID: 19950226
Exonuclease function of human Mre11 promotes deletional nonhomologous end joining.
Zhuang J, Jiang G, Willers H, Xia F
J Biol Chem. 2009
PubMed ID: 19744924
The mre11 complex and the response to dysfunctional telomeres.
Attwooll CL, Akpinar M, Petrini JH
Mol Cell Biol. 2009
PubMed ID: 19667076
Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2.
Dimitrova N, de Lange T
Mol Cell Biol. 2009
PubMed ID: 19667071
Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.
McWilliams RR, Bamlet WR, de Andrade M, Rider DN, Couch FJ, Cunningham JM, Matsumoto ME, Rabe KG, Hammer TJ, Petersen GM
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19690177
MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair.
Roques C, Coulombe Y, Delannoy M, Vignard J, Grossi S, Brodeur I, Rodrigue A, Gautier J, Stasiak AZ, Stasiak A, Constantinou A, Masson JY
EMBO J. 2009
PubMed ID: 19609304
Multiple roles for MRE11 at uncapped telomeres.
Deng Y, Guo X, Ferguson DO, Chang S
Nature. 2009
PubMed ID: 19633651
Physical interaction between replication protein A (RPA) and MRN: involvement of RPA2 phosphorylation and the N-terminus of RPA1.
Oakley GG, Tillison K, Opiyo SA, Glanzer JG, Horn JM, Patrick SM
Biochemistry. 2009
PubMed ID: 19586055
Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients.
Pugh TJ, Keyes M, Barclay L, Delaney A, Krzywinski M, Thomas D, Novik K, Yang C, Agranovich A, McKenzie M, Morris WJ, Olive PL, Marra MA, Moore RA
Clin Cancer Res. 2009
PubMed ID: 19638463
Multiple functions of MRN in end-joining pathways during isotype class switching.
Dinkelmann M, Spehalski E, Stoneham T, Buis J, Wu Y, Sekiguchi JM, Ferguson DO
Nat Struct Mol Biol. 2009
PubMed ID: 19633670
Role of mammalian Mre11 in classical and alternative nonhomologous end joining.
Xie A, Kwok A, Scully R
Nat Struct Mol Biol. 2009
PubMed ID: 19633669
Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells.
Rass E, Grabarz A, Plo I, Gautier J, Bertrand P, Lopez BS
Nat Struct Mol Biol. 2009
PubMed ID: 19633668
Common genetic variants in candidate genes and risk of familial lymphoid malignancies.
Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR
Br J Haematol. 2009
PubMed ID: 19573080
Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.
Rebbeck TR, Mitra N, Domchek SM, Wan F, Chuai S, Friebel TM, Panossian S, Spurdle A, Chenevix-Trench G, kConFab, Singer CF, Pfeiler G, Neuhausen SL, Lynch HT, Garber JE, Weitzel JN, Isaacs C, Couch F, Narod SA, Rubinstein WS, Tomlinson GE, Ganz PA, Olopade OI, Tung N, Blum JL, Greenberg R, Nathanson KL, Daly MB
Cancer Res. 2009
PubMed ID: 19584272
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
MRE11 complex links RECQ5 helicase to sites of DNA damage.
Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori AA, Gerrits B, Shevelev I, Janscak P
Nucleic Acids Res. 2009
PubMed ID: 19270065
Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection.
Karen KA, Hoey PJ, Young CS, Hearing P
J Virol. 2009
PubMed ID: 19244322
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.
Ouyang J, Shi Y, Valin A, Xuan Y, Gill G
Mol Cell. 2009
PubMed ID: 19394292
Genetic mutations associated with cigarette smoking in pancreatic cancer.
Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH
Cancer Res. 2009
PubMed ID: 19351817
RAD50 and NBS1 form a stable complex functional in DNA binding and tethering.
van der Linden E, Sanchez H, Kinoshita E, Kanaar R, Wyman C
Nucleic Acids Res. 2009
PubMed ID: 19151086
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.
Carson CT, Orazio NI, Lee DV, Suh J, Bekker-Jensen S, Araujo FD, Lakdawala SS, Lilley CE, Bartek J, Lukas J, Weitzman MD
EMBO J. 2009
PubMed ID: 19197236
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.
Helmink BA, Bredemeyer AL, Lee BS, Huang CY, Sharma GG, Walker LM, Bednarski JJ, Lee WL, Pandita TK, Bassing CH, Sleckman BP
J Exp Med. 2009
PubMed ID: 19221393
Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8.
Barrionuevo F, Georg I, Scherthan H, Lécureuil C, Guillou F, Wegner M, Scherer G
Dev Biol. 2009
PubMed ID: 19124014
Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway.
Shimada M, Sagae R, Kobayashi J, Habu T, Komatsu K
Cancer Res. 2009
PubMed ID: 19244116
Nuclear export of NBN is required for normal cellular responses to radiation.
Vissinga CS, Yeo TC, Warren S, Brawley JV, Phillips J, Cerosaletti K, Concannon P
Mol Cell Biol. 2009
PubMed ID: 19075003
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.
Shull ER, Lee Y, Nakane H, Stracker TH, Zhao J, Russell HR, Petrini JH, McKinnon PJ
Genes Dev. 2009
PubMed ID: 19171781
DNA double strand break repair enzymes function at multiple steps in retroviral infection.
Sakurai Y, Komatsu K, Agematsu K, Matsuoka M
Retrovirology. 2009
PubMed ID: 20003485
Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma.
Schuetz JM, MaCarthur AC, Leach S, Lai AS, Gallagher RP, Connors JM, Gascoyne RD, Spinelli JJ, Brooks-Wilson AR
BMC Med Genet. 2009
PubMed ID: 19917125
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
Mavaddat N, Dunning AM, Ponder BA, Easton DF, Pharoah PD
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19124506
Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.
Stracker TH, Williams BR, Deriano L, Theunissen JW, Adelman CA, Roth DB, Petrini JH
Mol Cell Biol. 2009
PubMed ID: 19015239
Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.
Bartkova J, Tommiska J, Oplustilova L, Aaltonen K, Tamminen A, Heikkinen T, Mistrik M, Aittomäki K, Blomqvist C, Heikkilä P, Lukas J, Nevanlinna H, Bartek J
Mol Oncol. 2008
PubMed ID: 19383352
Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064572
Common single-nucleotide polymorphisms in DNA double-strand break repair genes and breast cancer risk.
Pooley KA, Baynes C, Driver KE, Tyrer J, Azzato EM, Pharoah PD, Easton DF, Ponder BA, Dunning AM
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064565
RAD50/MRE11/NBS1 proteins in relation to tumour development and prognosis in patients with microsatellite stable colorectal cancer.
Gao J, Zhang H, Arbman G, Sun XF
Histol Histopathol. 2008
PubMed ID: 18830935
Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: A two-stage Spanish case-control study.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A
Gynecol Oncol. 2008
PubMed ID: 18950845
Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation.
Buis J, Wu Y, Deng Y, Leddon J, Westfield G, Eckersdorff M, Sekiguchi JM, Chang S, Ferguson DO
Cell. 2008
PubMed ID: 18854157
CDK targets Sae2 to control DNA-end resection and homologous recombination.
Huertas P, Cortés-Ledesma F, Sartori AA, Aguilera A, Jackson SP
Nature. 2008
PubMed ID: 18716619
ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.
Ewald B, Sampath D, Plunkett W
Cancer Res. 2008
PubMed ID: 18829552
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
A role for DEAD box 1 at DNA double-strand breaks.
Li L, Monckton EA, Godbout R
Mol Cell Biol. 2008
PubMed ID: 18710941
Assessment of carriers' frequency of a novel MRE11 mutation responsible for the rare ataxia telangiectasia-like disorder.
Alsbeih G, Al-Hadyan K, Al-Harbi N
Genet Test. 2008
PubMed ID: 18652530
Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex.
Guirouilh-Barbat J, Redon C, Pommier Y
Mol Biol Cell. 2008
PubMed ID: 18632984
Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links.
Bae JB, Mukhopadhyay SS, Liu L, Zhang N, Tan J, Akhter S, Liu X, Shen X, Li L, Legerski RJ
Oncogene. 2008
PubMed ID: 18469862
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity.
Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V
EMBO J. 2008
PubMed ID: 18596698
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage.
Stracker TH, Couto SS, Cordon-Cardo C, Matos T, Petrini JH
Mol Cell. 2008
PubMed ID: 18614044
DNA-repair genetic polymorphisms and risk of breast cancer in Cyprus.
Loizidou MA, Michael T, Neuhausen SL, Newbold RF, Marcou Y, Kakouri E, Daniel M, Papadopoulos P, Malas S, Hadjisavvas A, Kyriacou K
Breast Cancer Res Treat. 2008
PubMed ID: 18553220
Adenovirus type 5 early region 1B 55-kDa oncoprotein can promote cell transformation by a mechanism independent from blocking p53-activated transcription.
Härtl B, Zeller T, Blanchette P, Kremmer E, Dobner T
Oncogene. 2008
PubMed ID: 18212738
The interplay between hMLH1 and hMRE11: role in MMR and the effect of hMLH1 mutations.
Zhao N, Zhu F, Yuan F, Haick AK, Fukushige S, Gu L, Her C
Biochem Biophys Res Commun. 2008
PubMed ID: 18373977
Forkhead-associated domain of yeast Xrs2, a homolog of human Nbs1, promotes nonhomologous end joining through interaction with a ligase IV partner protein, Lif1.
Matsuzaki K, Shinohara A, Shinohara M
Genetics. 2008
PubMed ID: 18458108
A glycine-arginine domain in control of the human MRE11 DNA repair protein.
Déry U, Coulombe Y, Rodrigue A, Stasiak A, Richard S, Masson JY
Mol Cell Biol. 2008
PubMed ID: 18285453
Nbs1-dependent binding of Mre11 to adenovirus E4 mutant viral DNA is important for inhibiting DNA replication.
Mathew SS, Bridge E
Virology. 2008
PubMed ID: 18234271
Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.
Spycher C, Miller ES, Townsend K, Pavic L, Morrice NA, Janscak P, Stewart GS, Stucki M
J Cell Biol. 2008
PubMed ID: 18411308
DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions.
Morales M, Liu Y, Laiakis EC, Morgan WF, Nimer SD, Petrini JH
Cancer Res. 2008
PubMed ID: 18381424
A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner.
Wen Q, Scorah J, Phear G, Rodgers G, Rodgers S, Meuth M
Mol Biol Cell. 2008
PubMed ID: 18256278
Characterization of mre11 loss following HSV-1 infection.
Gregory DA, Bachenheimer SL
Virology. 2008
PubMed ID: 18177684
WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening.
Li B, Jog SP, Reddy S, Comai L
Mol Cell Biol. 2008
PubMed ID: 18212065
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites.
Haince JF, McDonald D, Rodrigue A, Déry U, Masson JY, Hendzel MJ, Poirier GG
J Biol Chem. 2008
PubMed ID: 18025084
Analysis of variants in DNA damage signalling genes in bladder cancer.
Choudhury A, Elliott F, Iles MM, Churchman M, Bristow RG, Bishop DT, Kiltie AE
BMC Med Genet. 2008
PubMed ID: 18638378
The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication.
Schwartz RA, Palacios JA, Cassell GD, Adam S, Giacca M, Weitzman MD
J Virol. 2007
PubMed ID: 17898048
The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.
Lee AY, Liu E, Wu X
J Biol Chem. 2007
PubMed ID: 17715134
Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres.
Zhong ZH, Jiang WQ, Cesare AJ, Neumann AA, Wadhwa R, Reddel RR
J Biol Chem. 2007
PubMed ID: 17693401
Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex.
Hsu HM, Wang HC, Chen ST, Hsu GC, Shen CY, Yu JC
Cancer Epidemiol Biomarkers Prev. 2007
PubMed ID: 17932350
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control.
Wu Y, Xiao S, Zhu XD
Nat Struct Mol Biol. 2007
PubMed ID: 17694070
The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.
Olson E, Nievera CJ, Liu E, Lee AY, Chen L, Wu X
Mol Cell Biol. 2007
PubMed ID: 17591703
The MRE11/RAD50/NBS1 complex destabilization in Lynch-syndrome patients.
Alemayehu A, Fridrichova I
Eur J Hum Genet. 2007
PubMed ID: 17534377
The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication.
Mathew SS, Bridge E
Virology. 2007
PubMed ID: 17477953
The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.
Olson E, Nievera CJ, Lee AY, Chen L, Wu X
J Biol Chem. 2007
PubMed ID: 17526493
Replication protein A is required for etoposide-induced assembly of MRE11/RAD50/NBS1 complex repair foci.
Robison JG, Bissler JJ, Dixon K
Cell Cycle. 2007
PubMed ID: 17700070
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K
J Biol Chem. 2007
PubMed ID: 17500065
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ
Science. 2007
PubMed ID: 17525332
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
Bhaskara V, Dupré A, Lengsfeld B, Hopkins BB, Chan A, Lee JH, Zhang X, Gautier J, Zakian V, Paull TT
Mol Cell. 2007
PubMed ID: 17349953
The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis.
Cherry SM, Adelman CA, Theunissen JW, Hassold TJ, Hunt PA, Petrini JH
Curr Biol. 2007
PubMed ID: 17291760
A role for MRE11, NBS1, and recombination junctions in replication and stable maintenance of EBV episomes.
Dheekollu J, Deng Z, Wiedmer A, Weitzman MD, Lieberman PM
PLoS ONE. 2007
PubMed ID: 18040525
Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence.
Ju YJ, Lee KH, Park JE, Yi YS, Yun MY, Ham YH, Kim TJ, Choi HM, Han GJ, Lee JH, Lee J, Han JS, Lee KM, Park GH
Exp Mol Med. 2006
PubMed ID: 17202845
Haplotypic variation in MRE11, RAD50 and NBS1 and risk of non-Hodgkin's lymphoma.
Rollinson S, Kesby H, Morgan GJ
Leuk Lymphoma. 2006
PubMed ID: 17169801
Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array.
Jiang Z, Hu J, Li X, Jiang Y, Zhou W, Lu D
Neurosci Lett. 2006
PubMed ID: 17034947
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Mre11-Rad50-Nbs1 complex is activated by hypertonicity.
Sheen MR, Kim SW, Jung JY, Ahn JY, Rhee JG, Kwon HM, Woo SK
Am J Physiol Renal Physiol. 2006
PubMed ID: 16788144
The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
Science. 2006
PubMed ID: 16959974
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y
J Biol Chem. 2006
PubMed ID: 16905549
Mre11 expression in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
Nakanishi K, Kumaki F, Hiroi S, Mukai M, Ikeda E, Kawai T
Arch Pathol Lab Med. 2006
PubMed ID: 16948520
Rapid phosphorylation of histone H2A.X following ionotropic glutamate receptor activation.
Crowe SL, Movsesyan VA, Jorgensen TJ, Kondratyev A
Eur J Neurosci. 2006
PubMed ID: 16706843
Rapid activation of ATR by ionizing radiation requires ATM and Mre11.
Myers JS, Cortez D
J Biol Chem. 2006
PubMed ID: 16431910
DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis.
Xu Y
Nat Rev Immunol. 2006
PubMed ID: 16498454
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
Nature. 2006
PubMed ID: 16554811
Does tumorigenesis select for or against mutations of the DNA repair-associated genes BRCA2 and MRE11?: considerations from somatic mutations in microsatellite unstable (MSI) gastrointestinal cancers.
van der Heijden MS, Brody JR, Elghalbzouri-Maghrani E, Zdzienicka MZ, Kern SE
BMC Genet. 2006
PubMed ID: 16417627
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.
Greenberg RA, Sobhian B, Pathania S, Cantor SB, Nakatani Y, Livingston DM
Genes Dev. 2006
PubMed ID: 16391231
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks.
Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP
Nat Cell Biol. 2006
PubMed ID: 16327781
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.
Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH
Genes Dev. 2005
PubMed ID: 16357220
Adenovirus exploits the cellular aggresome response to accelerate inactivation of the MRN complex.
Liu Y, Shevchenko A, Shevchenko A, Berk AJ
J Virol. 2005
PubMed ID: 16254336
Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.
Jung SY, Malovannaya A, Wei J, O'Malley BW, Qin J
Mol Endocrinol. 2005
PubMed ID: 16051665
Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA.
Moreno-Herrero F, de Jager M, Dekker NH, Kanaar R, Wyman C, Dekker C
Nature. 2005
PubMed ID: 16163361
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Global phosphoproteome of HT-29 human colon adenocarcinoma cells.
Kim JE, Tannenbaum SR, White FM
J Proteome Res. 2005
PubMed ID: 16083285
Methylation of MRE11 regulates its nuclear compartmentalization.
Boisvert FM, Hendzel MJ, Masson JY, Richard S
Cell Cycle. 2005
PubMed ID: 15970667
The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions.
Yabuki M, Fujii MM, Maizels N
Nat Immunol. 2005
PubMed ID: 15937485
Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination.
Restle A, Janz C, Wiesmüller L
Oncogene. 2005
PubMed ID: 15806145
Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation.
Strachan T
Curr Opin Genet Dev. 2005
PubMed ID: 15917200
ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.
Bhoumik A, Takahashi S, Breitweiser W, Shiloh Y, Jones N, Ronai Z
Mol Cell. 2005
PubMed ID: 15916964
hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair.
Vo AT, Zhu F, Wu X, Yuan F, Gao Y, Gu L, Li GM, Lee TH, Her C
EMBO Rep. 2005
PubMed ID: 15864295
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.
Lee JH, Paull TT
Science. 2005
PubMed ID: 15790808
DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci.
Robison JG, Lu L, Dixon K, Bissler JJ
J Biol Chem. 2005
PubMed ID: 15653682
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.
Falck J, Coates J, Jackson SP
Nature. 2005
PubMed ID: 15758953
Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.
Chen L, Morio T, Minegishi Y, Nakada S, Nagasawa M, Komatsu K, Chessa L, Villa A, Lecis D, Delia D, Mizutani S
Cancer Sci. 2005
PubMed ID: 15723659
Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder.
Fernet M, Gribaa M, Salih MA, Seidahmed MZ, Hall J, Koenig M
Hum Mol Genet. 2005
PubMed ID: 15574463
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.
Liu D, O'Connor MS, Qin J, Songyang Z
J Biol Chem. 2004
PubMed ID: 15383534
MRE11 expression is impaired in gastric cancer with microsatellite instability.
Ottini L, Falchetti M, Saieva C, De Marco M, Masala G, Zanna I, Paglierani M, Giannini G, Gulino A, Nesi G, Mariani Costantini R, Palli D
Carcinogenesis. 2004
PubMed ID: 15319296
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.
Zhang X, Succi J, Feng Z, Prithivirajsingh S, Story MD, Legerski RJ
Mol Cell Biol. 2004
PubMed ID: 15456891
MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder.
Delia D, Piane M, Buscemi G, Savio C, Palmeri S, Lulli P, Carlessi L, Fontanella E, Chessa L
Hum Mol Genet. 2004
PubMed ID: 15269180
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.
Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC
J Cell Biol. 2004
PubMed ID: 15364958
Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains.
Jacobsen E, Beach T, Shen Y, Li R, Chang Y
Brain Res Mol Brain Res. 2004
PubMed ID: 15337312
Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.
Cerosaletti K, Concannon P
J Biol Chem. 2004
PubMed ID: 15234984
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15302935
Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks.
Robison JG, Elliott J, Dixon K, Oakley GG
J Biol Chem. 2004
PubMed ID: 15180989
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention.
Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, Lerenthal Y, Jackson SP, Bartek J, Lukas J
EMBO J. 2004
PubMed ID: 15201865
The human Rap1 protein complex and modulation of telomere length.
O'Connor MS, Safari A, Liu D, Qin J, Songyang Z
J Biol Chem. 2004
PubMed ID: 15100233
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
Herbig U, Jobling WA, Chen BP, Chen DJ, Sedivy JM
Mol Cell. 2004
PubMed ID: 15149599
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.
Cheng WH, von Kobbe C, Opresko PL, Arthur LM, Komatsu K, Seidman MM, Carney JP, Bohr VA
J Biol Chem. 2004
PubMed ID: 15026416
Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability.
Giannini G, Rinaldi C, Ristori E, Ambrosini MI, Cerignoli F, Viel A, Bidoli E, Berni S, D'Amati G, Scambia G, Frati L, Screpanti I, Gulino A
Oncogene. 2004
PubMed ID: 15048091
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Transfection of human tumour cells with Mre11 siRNA and the increase in radiation sensitivity and the reduction in heat-induced radiosensitization.
Xu M, Myerson RJ, Hunt C, Kumar S, Moros EG, Straube WL, Roti Roti JL
Int J Hyperthermia. 2004
PubMed ID: 15195510
A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts.
Donahue SL, Campbell C
Nucleic Acids Res. 2004
PubMed ID: 15199173
Structural and functional analysis of Mre11-3.
Arthur LM, Gustausson K, Hopfner KP, Carson CT, Stracker TH, Karcher A, Felton D, Weitzman MD, Tainer J, Carney JP
Nucleic Acids Res. 2004
PubMed ID: 15047855
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.
Surpili MJ, Delben TM, Kobarg J
Biochemistry. 2003
PubMed ID: 14690447
The Mre11 complex is required for ATM activation and the G2/M checkpoint.
Carson CT, Schwartz RA, Stracker TH, Lilley CE, Lee DV, Weitzman MD
EMBO J. 2003
PubMed ID: 14657032
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice.
Theunissen JW, Kaplan MI, Hunt PA, Williams BR, Ferguson DO, Alt FW, Petrini JH
Mol Cell. 2003
PubMed ID: 14690604
Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility.
Heikkinen K, Karppinen SM, Soini Y, Mäkinen M, Winqvist R
J Med Genet. 2003
PubMed ID: 14684699
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.
Xu X, Stern DF
FASEB J. 2003
PubMed ID: 14519663
Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas.
Angèle S, Treilleux I, Brémond A, Tanière P, Hall J
Histopathology. 2003
PubMed ID: 14511253
High NaCl causes Mre11 to leave the nucleus, disrupting DNA damage signaling and repair.
Dmitrieva NI, Bulavin DV, Burg MB
Am J Physiol Renal Physiol. 2003
PubMed ID: 12684226
Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation.
Cerosaletti KM, Concannon P
J Biol Chem. 2003
PubMed ID: 12679336
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y
J Biol Chem. 2003
PubMed ID: 12660252
The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase.
Franchitto A, Pichierri P, Piergentili R, Crescenzi M, Bignami M, Palitti F
Oncogene. 2003
PubMed ID: 12687013
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ
Nature. 2003
PubMed ID: 12607005
MDC1 is required for the intra-S-phase DNA damage checkpoint.
Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, Bartek J, Jackson SP
Nature. 2003
PubMed ID: 12607003
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Interaction of FANCD2 and NBS1 in the DNA damage response.
Nakanishi K, Taniguchi T, Ranganathan V, New HV, Moreau LA, Stotsky M, Mathew CG, Kastan MB, Weaver DT, D'Andrea AD
Nat Cell Biol. 2002
PubMed ID: 12447395
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain.
Kobayashi J, Tauchi H, Sakamoto S, Nakamura A, Morishima K, Matsuura S, Kobayashi T, Tamai K, Tanimoto K, Komatsu K
Curr Biol. 2002
PubMed ID: 12419185
Cancer predisposition and hematopoietic failure in Rad50(S/S) mice.
Bender CF, Sikes ML, Sullivan R, Huye LE, Le Beau MM, Roth DB, Mirzoeva OK, Oltz EM, Petrini JH
Genes Dev. 2002
PubMed ID: 12208847
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.
Stracker TH, Carson CT, Weitzman MD
Nature. 2002
PubMed ID: 12124628
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.
Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J
Genes Dev. 2002
PubMed ID: 11877377
Human MRE11 is inactivated in mismatch repair-deficient cancers.
Giannini G, Ristori E, Cerignoli F, Rinaldi C, Zani M, Viel A, Ottini L, Crescenzi M, Martinotti S, Bignami M, Frati L, Screpanti I, Gulino A
EMBO Rep. 2002
PubMed ID: 11850399
Redistribution of BRCA1 among four different protein complexes following replication blockage.
Chiba N, Parvin JD
J Biol Chem. 2001
PubMed ID: 11504724
Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Piao Y, Ko NT, Lim MK, Ko MS
Genome Res. 2001
PubMed ID: 11544199
Direct DNA binding by Brca1.
Paull TT, Cortez D, Bowers B, Elledge SJ, Gellert M
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11353843
Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase.
Hopfner KP, Karcher A, Craig L, Woo TT, Carney JP, Tainer JA
Cell. 2001
PubMed ID: 11371344
hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay.
Pitts SA, Kullar HS, Stankovic T, Stewart GS, Last JI, Bedenham T, Armstrong SJ, Piane M, Chessa L, Taylor AM, Byrd PJ
Hum Mol Genet. 2001
PubMed ID: 11371508
Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization.
Desai-Mehta A, Cerosaletti KM, Concannon P
Mol Cell Biol. 2001
PubMed ID: 11238951
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Alterations of the double-strand break repair gene MRE11 in cancer.
Fukuda T, Sumiyoshi T, Takahashi M, Kataoka T, Asahara T, Inui H, Watatani M, Yasutomi M, Kamada N, Miyagawa K
Cancer Res. 2001
PubMed ID: 11196167
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.
de Vries H, Rüegsegger U, Hübner W, Friedlein A, Langen H, Keller W
EMBO J. 2000
PubMed ID: 11060040
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes.
Lanson NA, Egeland DB, Royals BA, Claycomb WC
Nucleic Acids Res. 2000
PubMed ID: 10908350
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.
Zhu XD, Küster B, Mann M, Petrini JH, de Lange T
Nat Genet. 2000
PubMed ID: 10888888
ATM-dependent phosphorylation of nibrin in response to radiation exposure.
Gatei M, Young D, Cerosaletti KM, Desai-Mehta A, Spring K, Kozlov S, Lavin MF, Gatti RA, Concannon P, Khanna K
Nat Genet. 2000
PubMed ID: 10802669
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J
Genes Dev. 2000
PubMed ID: 10783165
Localisation of RAD50 and MRE11 in spermatocyte nuclei of mouse and rat.
Eijpe M, Offenberg H, Goedecke W, Heyting C
Chromosoma. 2000
PubMed ID: 10855503
Substrate specificities and identification of putative substrates of ATM kinase family members.
Kim ST, Lim DS, Canman CE, Kastan MB
J Biol Chem. 1999
PubMed ID: 10608806
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder.
Stewart GS, Maser RS, Stankovic T, Bressan DA, Kaplan MI, Jaspers NG, Raams A, Byrd PJ, Petrini JH, Taylor AM
Cell. 1999
PubMed ID: 10612394
Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis.
Goedecke W, Eijpe M, Offenberg HH, van Aalderen M, Heyting C
Nat Genet. 1999
PubMed ID: 10508516
Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.
Zhong Q, Chen CF, Li S, Chen Y, Wang CC, Xiao J, Chen PL, Sharp ZD, Lee WH
Science. 1999
PubMed ID: 10426999
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions.
Chamankhah M, Wei YF, Xiao W
Gene. 1998
PubMed ID: 9931460
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.
Trujillo KM, Yuan SS, Lee EY, Sung P
J Biol Chem. 1998
PubMed ID: 9705271
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.
Paull TT, Gellert M
Mol Cell. 1998
PubMed ID: 9651580
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.
Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR, Hays L, Morgan WF, Petrini JH
Cell. 1998
PubMed ID: 9590181
Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells.
Xiao Y, Weaver DT
Nucleic Acids Res. 1997
PubMed ID: 9224597
Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair.
Dolganov GM, Maser RS, Novikov A, Tosto L, Chong S, Bressan DA, Petrini JH
Mol Cell Biol. 1996
PubMed ID: 8756642
Isolation and characterization of the human MRE11 homologue.
Petrini JH, Walsh ME, DiMare C, Chen XN, Korenberg JR, Weaver DT
Genomics. 1995
PubMed ID: 8530104

Model Organism Phenotype Links from MGI Top Help

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	Human	Mouse	Rat
Entrez Gene	4361	17535	64046
EnsEMBL Gene(s)	ENSG00000020922 LRG_85	ENSMUSG00000031928	ENSRNOG00000009506
Unigene	Hs.192649	Mm.149071	Rn.209040
Homologene	MRE11A	Mre11a	Mre11a
OMIM	600814	N/A	N/A
GeneCards	MRE11A	N/A	N/A
Beta Cell Genomics	DT.100815706 DT.441210 DT.86852984 DT.95268844	DT.490433 DT.97351375	N/A
Reactome	P49959	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	4361	17535	64046

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