• About T1DBase
• Regions
  • Human T1D Regions
  • Mouse T1D Regions
    • Linkage Regions
    • Orthologous Regions
  • Rat T1D Regions
    • Linkage Regions
    • Orthologous Regions
    • QTL Regions
• Genome Browser
  • Human GBrowse
  • Mouse GBrowse
  • Rat GBrowse
• Tools
  • Gene Dossier
  • Beta Cell Gene Atlas
  • Batch Query
  • Sequence Search
  • HaemAtlas Search
  • Mouse Strain Search
• Data
  • Poster Pages
  • Downloads
  • Data Submission
• Help
  • FAQ
  • T1DBase Tutorial
• Contact Us

• Page Sections
  • Summary
  • Regions of Interest Overlapping this feature
  • Gene Overview
  • Beta Cell Gene Atlas
  • Tissue Expression
  • HaemAtlas Expression
  • Interactions
  • Cross-Reference to Pathways and GO Terms
  • Publications
  • Model Organism Phenotype Links
  • External Links
  • External resources (dkCOIN)

ASCL2

Gene Description:   achaete-scute complex homolog 2 (Drosophila) Synonyms:   ASH2, MASH2, bHLHa45, ASCL2, HASH2, Mash2, Ascl2, 2410083I15Rik Orthologs:   Human ASCL2 (protein-coding), Mouse Ascl2 (protein-coding), Rat Ascl2 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL Human-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 2 Rat: 3

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
11p15.5	Human	chr11:2068424..2308304	0.24	37	rs689 rs7111341

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Not assigned	Mouse	chr7:117936155..152524553	34.59	560

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 11p15.5 Orthologous Region	Mouse	chr7:149800921..150160408	0.36	6
Human 11p15.5 Orthologous Region	Rat	chr1:202870115..203251634	0.38	4
Iddm25	Rat	chr1:193831373..230411453	36.58	766

(Human) GRCh37 - chr11:2289725..2292182 (2.46 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr7:150152727..150155169 (2.44 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr1:203242129..203244480 (2.35 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for ASCL2: The ASCL2 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs ASCL2   HCFC1   BioGRID  empirical  12670868  ASCL2   MLL3   BioGRID  empirical  12482968  ASCL2   RBBP5   BioGRID  empirical  12482968  ASCL2   TUBA4A   BioGRID  empirical  12482968  ASCL2   CALM1   HPRD  empirical  10757985  ASCL2   CALM2   HPRD  empirical  10757985  ASCL2   CALM3   HPRD  empirical  10757985

View all

KEGG Network: None available   None available.

Biocarta: None available   None available.

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 19   Negative regulation of transcription from RNA polymerase II promoter GO:0000122 Response to hypoxia GO:0001666 In utero embryonic development GO:0001701 Placenta development GO:0001890 Sequence-specific DNA binding transcription factor activity GO:0003700 Nucleus GO:0005634 Cytoplasm GO:0005737 Transcription, DNA-dependent GO:0006351 Regulation of transcription, DNA-dependent GO:0006355 Multicellular organismal development GO:0007275 Central nervous system development GO:0007417 Peripheral nervous system development GO:0007422 Negative regulation of Schwann cell proliferation GO:0010626 Cell differentiation GO:0030154 Somatic stem cell maintenance GO:0035019 Sequence-specific DNA binding GO:0043565 Spongiotrophoblast differentiation GO:0060708 Spongiotrophoblast layer development GO:0060712 E-box binding GO:0070888

	KEGG Network: None available
	Biocarta: None available
	Reactome: None available
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 19 Negative regulation of transcription from RNA polymerase II promoter GO:0000122 Response to hypoxia GO:0001666 In utero embryonic development GO:0001701 Placenta development GO:0001890 Sequence-specific DNA binding transcription factor activity GO:0003700 Nucleus GO:0005634 Cytoplasm GO:0005737 Transcription, DNA-dependent GO:0006351 Regulation of transcription, DNA-dependent GO:0006355 Multicellular organismal development GO:0007275 Central nervous system development GO:0007417 Peripheral nervous system development GO:0007422 Negative regulation of Schwann cell proliferation GO:0010626 Cell differentiation GO:0030154 Somatic stem cell maintenance GO:0035019 Sequence-specific DNA binding GO:0043565 Spongiotrophoblast differentiation GO:0060708 Spongiotrophoblast layer development GO:0060712 E-box binding GO:0070888

Publications: 140

• Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development.
  Sripathy S, Lee M, Vasioukhin V
  Mol Cell Biol. 2011
  PubMed ID: 21606200
   
  
• Altered gene expression and spongiotrophoblast differentiation in placenta from a mouse model of diabetes in pregnancy.
  Salbaum JM, Kruger C, Zhang X, Delahaye NA, Pavlinkova G, Burk DH, Kappen C
  Diabetologia. 2011
  PubMed ID: 21491160
   
  
• Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction.
  Oh-McGinnis R, Bogutz AB, Lefebvre L
  Dev Biol. 2011
  PubMed ID: 21238448
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Oct1 regulates trophoblast development during early mouse embryogenesis.
  Sebastiano V, Dalvai M, Gentile L, Schubart K, Sutter J, Wu GM, Tapia N, Esch D, Ju JY, Hübner K, Bravo MJ, Schöler HR, Cavaleri F, Matthias P
  Development. 2010
  PubMed ID: 20876643
   
  
• A genomic imprinting defect in mice traced to a single gene.
  Rentsendorj A, Mohan S, Szabó P, Mann JR
  Genetics. 2010
  PubMed ID: 20713691
   
  
• Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability.
  Firulli BA, McConville DP, Byers JS, Vincentz JW, Barnes RM, Firulli AB
  Dev Dyn. 2010
  PubMed ID: 20737509
   
  
• Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation.
  Sun X, Xie H, Yang J, Wang H, Bradshaw HB, Dey SK
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20837524
   
  
• A Cdh1HA knock-in allele rescues the Cdh1-/- phenotype but shows essential Cdh1 function during placentation.
  Stemmler MP, Bedzhov I
  Dev Dyn. 2010
  PubMed ID: 20652949
   
  
• Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain.
  Stange DE, Engel F, Longerich T, Koo BK, Koch M, Delhomme N, Aigner M, Toedt G, Schirmacher P, Lichter P, Weitz J, Radlwimmer B
  Gut. 2010
  PubMed ID: 20479215
   
  
• An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo.
  Spruce T, Pernaute B, Di-Gregorio A, Cobb BS, Merkenschlager M, Manzanares M, Rodriguez TA
  Dev Cell. 2010
  PubMed ID: 20708584
   
  
• Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1.
  Mohammad F, Mondal T, Guseva N, Pandey GK, Kanduri C
  Development. 2010
  PubMed ID: 20573698
   
  
• Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo.
  Morsut L, Yan KP, Enzo E, Aragona M, Soligo SM, Wendling O, Mark M, Khetchoumian K, Bressan G, Chambon P, Dupont S, Losson R, Piccolo S
  Development. 2010
  PubMed ID: 20573697
   
  
• N-cadherin can structurally substitute for E-cadherin during intestinal development but leads to polyp formation.
  Libusova L, Stemmler MP, Hierholzer A, Schwarz H, Kemler R
  Development. 2010
  PubMed ID: 20534673
   
  
• Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis.
  Chu J, Shen MM
  Dev Biol. 2010
  PubMed ID: 20346354
   
  
• Upregulation of imprinted genes in mice: an insight into the intensity of gene expression and the evolution of genomic imprinting.
  Zaitoun I, Downs KM, Rosa GJ, Khatib H
  Epigenetics. 2010
  PubMed ID: 20168089
   
  
• A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunction.
  Wansleeben C, Feitsma H, Tertoolen L, Kroon C, Guryev V, Cuppen E, Meijlink F
  Int J Dev Biol. 2010
  PubMed ID: 21302256
   
  
• Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome.
  Oh-McGinnis R, Bogutz AB, Lee KY, Higgins MJ, Lefebvre L
  BMC Dev Biol. 2010
  PubMed ID: 20459838
   
  
• The imprinted Phlda2 gene regulates extraembryonic energy stores.
  Tunster SJ, Tycko B, John RM
  Mol Cell Biol. 2010
  PubMed ID: 19884348
   
  
• A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
  Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
  Dev Cell. 2009
  PubMed ID: 20059953
   
  
• Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse.
  Oh S, Lee D, Kim T, Kim TS, Oh HJ, Hwang CY, Kong YY, Kwon KS, Lim DS
  Mol Cell Biol. 2009
  PubMed ID: 19786569
   
  
• The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region.
  Lefebvre L, Mar L, Bogutz A, Oh-McGinnis R, Mandegar MA, Paderova J, Gertsenstein M, Squire JA, Nagy A
  Hum Mol Genet. 2009
  PubMed ID: 19684026
   
  
• Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
  Nishiyama A, Xin L, Sharov AA, Thomas M, Mowrer G, Meyers E, Piao Y, Mehta S, Yee S, Nakatake Y, Stagg C, Sharova L, Correa-Cerro LS, Bassey U, Hoang H, Kim E, Tapnio R, Qian Y, Dudekula D, Zalzman M, Li M, Falco G, Yang HT, Lee SL, Monti M, Stanghellini I, Islam MN, Nagaraja R, Goldberg I, Wang W, Longo DL, Schlessinger D, Ko MS
  Cell Stem Cell. 2009
  PubMed ID: 19796622
   
  
• LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine.
  Garcia MI, Ghiani M, Lefort A, Libert F, Strollo S, Vassart G
  Dev Biol. 2009
  PubMed ID: 19394326
   
  
• Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice.
  Sferruzzi-Perri AN, Macpherson AM, Roberts CT, Robertson SA
  Biol Reprod. 2009
  PubMed ID: 19228596
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• Transcription factor achaete scute-like 2 controls intestinal stem cell fate.
  van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, Stange DE, Begthel H, van den Born M, Guryev V, Oving I, van Es JH, Barker N, Peters PJ, van de Wetering M, Clevers H
  Cell. 2009
  PubMed ID: 19269367
   
  
• Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo.
  Yamamoto M, Beppu H, Takaoka K, Meno C, Li E, Miyazono K, Hamada H
  J Cell Biol. 2009
  PubMed ID: 19153222
   
  
• Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5.
  Ng RK, Dean W, Dawson C, Lucifero D, Madeja Z, Reik W, Hemberger M
  Nat Cell Biol. 2008
  PubMed ID: 18836439
   
  
• Transcriptional regulator BPTF/FAC1 is essential for trophoblast differentiation during early mouse development.
  Goller T, Vauti F, Ramasamy S, Arnold HH
  Mol Cell Biol. 2008
  PubMed ID: 18794365
   
  
• Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.
  Stevens JD, Roalson EH, Skinner MK
  Differentiation. 2008
  PubMed ID: 18557763
   
  
• Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.
  Landry J, Sharov AA, Piao Y, Sharova LV, Xiao H, Southon E, Matta J, Tessarollo L, Zhang YE, Ko MS, Kuehn MR, Yamaguchi TP, Wu C
  PLoS Genet. 2008
  PubMed ID: 18974875
   
  
• Multiple roles of Notch signaling in the regulation of epidermal development.
  Moriyama M, Durham AD, Moriyama H, Hasegawa K, Nishikawa S, Radtke F, Osawa M
  Dev Cell. 2008
  PubMed ID: 18410734
   
  
• GUDMAP: the genitourinary developmental molecular anatomy project.
  McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
  J Am Soc Nephrol. 2008
  PubMed ID: 18287559
   
  
• Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice.
  Pan Z, Sikandar S, Witherspoon M, Dizon D, Nguyen T, Benirschke K, Wiley C, Vrana P, Lipkin SM
  Dev Dyn. 2008
  PubMed ID: 18163532
   
  
• G9a histone methyltransferase contributes to imprinting in the mouse placenta.
  Wagschal A, Sutherland HG, Woodfine K, Henckel A, Chebli K, Schulz R, Oakey RJ, Bickmore WA, Feil R
  Mol Cell Biol. 2008
  PubMed ID: 18039842
   
  
• Epigenetic and phenotypic consequences of a truncation disrupting the imprinted domain on distal mouse chromosome 7.
  Oh R, Ho R, Mar L, Gertsenstein M, Paderova J, Hsien J, Squire JA, Higgins MJ, Nagy A, Lefebvre L
  Mol Cell Biol. 2008
  PubMed ID: 18039841
   
  
• Two distinct mechanisms of silencing by the KvDMR1 imprinting control region.
  Shin JY, Fitzpatrick GV, Higgins MJ
  EMBO J. 2008
  PubMed ID: 18079696
   
  
• Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success.
  Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, DuBois RN, Dey SK
  J Biol Chem. 2007
  PubMed ID: 17965409
   
  
• Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome.
  Bondareva AA, Capecchi MR, Iverson SV, Li Y, Lopez NI, Lucas O, Merrill GF, Prigge JR, Siders AM, Wakamiya M, Wallin SL, Schmidt EE
  Free Radic Biol Med. 2007
  PubMed ID: 17697936
   
  
• HOP/NECC1, a novel regulator of mouse trophoblast differentiation.
  Asanoma K, Kato H, Yamaguchi S, Shin CH, Liu ZP, Kato K, Inoue T, Miyanari Y, Yoshikawa K, Sonoda K, Fukushima K, Wake N
  J Biol Chem. 2007
  PubMed ID: 17576768
   
  
• Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.
  Kaji K, Nichols J, Hendrich B
  Development. 2007
  PubMed ID: 17287250
   
  
• Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner.
  Kamei Y, Suganami T, Kohda T, Ishino F, Yasuda K, Miura S, Ezaki O, Ogawa Y
  FEBS Lett. 2007
  PubMed ID: 17182038
   
  
• A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA.
  Green K, Lewis A, Dawson C, Dean W, Reinhart B, Chaillet JR, Reik W
  Mamm Genome. 2007
  PubMed ID: 17245608
   
  
• DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner.
  Oda M, Yamagiwa A, Yamamoto S, Nakayama T, Tsumura A, Sasaki H, Nakao K, Li E, Okano M
  Genes Dev. 2006
  PubMed ID: 17182866
   
  
• Detection of HASH2 (ASCL2) gene expression in gestational trophoblastic disease.
  Shahib MN, Martaadisoebrata D, Kato H
  J Reprod Med. 2006
  PubMed ID: 17165436
   
  
• Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo.
  Lewis A, Green K, Dawson C, Redrup L, Huynh KD, Lee JT, Hemberger M, Reik W
  Development. 2006
  PubMed ID: 17021040
   
  
• Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2.
  Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH
  Mol Cell Biol. 2006
  PubMed ID: 16966370
   
  
• Loss of the maternal imprint in Dnmt3Lmat-/- mice leads to a differentiation defect in the extraembryonic tissue.
  Arima T, Hata K, Tanaka S, Kusumi M, Li E, Kato K, Shiota K, Sasaki H, Wake N
  Dev Biol. 2006
  PubMed ID: 16920095
   
  
• Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia.
  Jubb AM, Chalasani S, Frantz GD, Smits R, Grabsch HI, Kavi V, Maughan NJ, Hillan KJ, Quirke P, Koeppen H
  Oncogene. 2006
  PubMed ID: 16568095
   
  
• Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes.
  Mancini-Dinardo D, Steele SJ, Levorse JM, Ingram RS, Tilghman SM
  Genes Dev. 2006
  PubMed ID: 16702402
   
  
• Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta.
  Nadra K, Anghel SI, Joye E, Tan NS, Basu-Modak S, Trono D, Wahli W, Desvergne B
  Mol Cell Biol. 2006
  PubMed ID: 16581799
   
  
• Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development.
  Georgiades P, Rossant J
  Development. 2006
  PubMed ID: 16481355
   
  
• The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice.
  van Nes J, de Graaff W, Lebrin F, Gerhard M, Beck F, Deschamps J
  Development. 2006
  PubMed ID: 16396910
   
  
• Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality.
  Ono R, Nakamura K, Inoue K, Naruse M, Usami T, Wakisaka-Saito N, Hino T, Suzuki-Migishima R, Ogonuki N, Miki H, Kohda T, Ogura A, Yokoyama M, Kaneko-Ishino T, Ishino F
  Nat Genet. 2006
  PubMed ID: 16341224
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Foxd3 is required in the trophoblast progenitor cell lineage of the mouse embryo.
  Tompers DM, Foreman RK, Wang Q, Kumanova M, Labosky PA
  Dev Biol. 2005
  PubMed ID: 16039639
   
  
• Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta.
  Tanaka H, Nagaike K, Takeda N, Itoh H, Kohama K, Fukushima T, Miyata S, Uchiyama S, Uchinokura S, Shimomura T, Miyazawa K, Kitamura N, Yamada G, Kataoka H
  Mol Cell Biol. 2005
  PubMed ID: 15964823
   
  
• Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality.
  Hitz C, Vogt-Weisenhorn D, Ruiz P, Wurst W, Floss T
  Genesis. 2005
  PubMed ID: 15887267
   
  
• The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster.
  Cerrato F, Sparago A, Di Matteo I, Zou X, Dean W, Sasaki H, Smith P, Genesio R, Bruggemann M, Reik W, Riccio A
  Hum Mol Genet. 2005
  PubMed ID: 15640248
   
  
• Mouse brain organization revealed through direct genome-scale TF expression analysis.
  Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
  Science. 2004
  PubMed ID: 15618518
   
  
• Polybromo protein BAF180 functions in mammalian cardiac chamber maturation.
  Wang Z, Zhai W, Richardson JA, Olson EN, Meneses JJ, Firpo MT, Kang C, Skarnes WC, Tjian R
  Genes Dev. 2004
  PubMed ID: 15601824
   
  
• Peroxisome proliferator-activated receptor gamma controls Muc1 transcription in trophoblasts.
  Shalom-Barak T, Nicholas JM, Wang Y, Zhang X, Ong ES, Young TH, Gendler SJ, Evans RM, Barak Y
  Mol Cell Biol. 2004
  PubMed ID: 15572671
   
  
• Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes.
  Umlauf D, Goto Y, Cao R, Cerqueira F, Wagschal A, Zhang Y, Feil R
  Nat Genet. 2004
  PubMed ID: 15516932
   
  
• Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation.
  Lewis A, Mitsuya K, Umlauf D, Smith P, Dean W, Walter J, Higgins M, Feil R, Reik W
  Nat Genet. 2004
  PubMed ID: 15516931
   
  
• Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment.
  Guzman-Ayala M, Ben-Haim N, Beck S, Constam DB
  Proc Natl Acad Sci U S A. 2004
  PubMed ID: 15505202
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• Placental growth retardation due to loss of imprinting of Phlda2.
  Salas M, John R, Saxena A, Barton S, Frank D, Fitzpatrick G, Higgins MJ, Tycko B
  Mech Dev. 2004
  PubMed ID: 15327781
   
  
• Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice.
  Moser M, Li Y, Vaupel K, Kretzschmar D, Kluge R, Glynn P, Buettner R
  Mol Cell Biol. 2004
  PubMed ID: 14749382
   
  
• The expression of proprotein convertase PACE4 is highly regulated by Hash-2 in placenta: possible role of placenta-specific basic helix-loop-helix transcription factor, human achaete-scute homologue-2.
  Koide S, Yoshida I, Tsuji A, Matsuda Y
  J Biochem. 2003
  PubMed ID: 14561729
   
  
• USF1 and USF2 mediate inhibition of human trophoblast differentiation and CYP19 gene expression by Mash-2 and hypoxia.
  Jiang B, Mendelson CR
  Mol Cell Biol. 2003
  PubMed ID: 12917334
   
  
• Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.
  Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W
  Genes Dev. 2003
  PubMed ID: 12670868
   
  
• Genome imprinting regulated by the mouse Polycomb group protein Eed.
  Mager J, Montgomery ND, de Villena FP, Magnuson T
  Nat Genet. 2003
  PubMed ID: 12627233
   
  
• Structure and regulation of the murine Mash2 gene.
  Stepan H, Marqwardt W, Kuhn Y, Höckel M, Schultheiss HP, Walther T
  Biol Reprod. 2003
  PubMed ID: 12493693
   
  
• Carcinoembryonic antigen-related cell adhesion molecule 10 expressed specifically early in pregnancy in the decidua is dispensable for normal murine development.
  Finkenzeller D, Fischer B, Lutz S, Schrewe H, Shimizu T, Zimmermann W
  Mol Cell Biol. 2003
  PubMed ID: 12482980
   
  
• Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.
  Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW
  Mol Cell Biol. 2003
  PubMed ID: 12482968
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
  Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH.
  Mahy NL, Perry PE, Bickmore WA
  J Cell Biol. 2002
  PubMed ID: 12473685
   
  
• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
  Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
  Nature. 2002
  PubMed ID: 12466851
   
  
• Deletion of the cancer-amplified coactivator AIB3 results in defective placentation and embryonic lethality.
  Kuang SQ, Liao L, Zhang H, Pereira FA, Yuan Y, DeMayo FJ, Ko L, Xu J
  J Biol Chem. 2002
  PubMed ID: 12368298
   
  
• Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1.
  Fitzpatrick GV, Soloway PD, Higgins MJ
  Nat Genet. 2002
  PubMed ID: 12410230
   
  
• The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.
  Wang J, Mager J, Schnedier E, Magnuson T
  Mamm Genome. 2002
  PubMed ID: 12370779
   
  
• Mammalian achaete scute homolog 2 is expressed in the adult sciatic nerve and regulates the expression of Krox24, Mob-1, CXCR4, and p57kip2 in Schwann cells.
  Küry P, Greiner-Petter R, Cornely C, Jürgens T, Müller HW
  J Neurosci. 2002
  PubMed ID: 12196582
   
  
• Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development.
  Auman HJ, Nottoli T, Lakiza O, Winger Q, Donaldson S, Williams T
  Development. 2002
  PubMed ID: 12015300
   
  
• The human ASCL2 gene escaping genomic imprinting and its expression pattern.
  Miyamoto T, Hasuike S, Jinno Y, Soejima H, Yun K, Miura K, Ishikawa M, Niikawa N
  J Assist Reprod Genet. 2002
  PubMed ID: 12099555
   
  
• Microarray expression profiling of tissues from mice with uniparental duplications of chromosomes 7 and 11 to identify imprinted genes.
  Choi JD, Underkoffler LA, Collins JN, Marchegiani SM, Terry NA, Beechey CV, Oakey RJ
  Mamm Genome. 2001
  PubMed ID: 11668390
   
  
• Wnt7b regulates placental development in mice.
  Parr BA, Cornish VA, Cybulsky MI, McMahon AP
  Dev Biol. 2001
  PubMed ID: 11543617
   
  
• The Human Achaete Scute Homolog 2 gene contains two promotors, generating overlapping transcripts and encoding two proteins with different nuclear localization.
  Westerman BA, Poutsma A, Looijenga LH, Wouters D, van Wijk IJ, Oudejans CB
  Placenta. 2001
  PubMed ID: 11440538
   
  
• Functional annotation of a full-length mouse cDNA collection.
  Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
  Nature. 2001
  PubMed ID: 11217851
   
  
• RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
  Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
  Genome Res. 2000
  PubMed ID: 11076861
   
  
• Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain.
  Onyango P, Miller W, Lehoczky J, Leung CT, Birren B, Wheelan S, Dewar K, Feinberg AP
  Genome Res. 2000
  PubMed ID: 11076855
   
  
• Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting.
  Engemann S, Strödicke M, Paulsen M, Franck O, Reinhardt R, Lane N, Reik W, Walter J
  Hum Mol Genet. 2000
  PubMed ID: 11063728
   
  
• Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
  Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
  Genome Res. 2000
  PubMed ID: 11042159
   
  
• PLAC1, an Xq26 gene with placenta-specific expression.
  Cocchia M, Huber R, Pantano S, Chen EY, Ma P, Forabosco A, Ko MS, Schlessinger D
  Genomics. 2000
  PubMed ID: 10995572
   
  
• Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis.
  Mudgett JS, Ding J, Guh-Siesel L, Chartrain NA, Yang L, Gopal S, Shen MM
  Proc Natl Acad Sci U S A. 2000
  PubMed ID: 10973481
   
  
• Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse.
  Paulsen M, El-Maarri O, Engemann S, Strödicke M, Franck O, Davies K, Reinhardt R, Reik W, Walter J
  Hum Mol Genet. 2000
  PubMed ID: 10915772
   
  
• Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family.
  Enklaar T, Esswein M, Oswald M, Hilbert K, Winterpacht A, Higgins M, Zabel B, Prawitt D
  Genomics. 2000
  PubMed ID: 10903843
   
  
• A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors.
  Onions J, Hermann S, Grundström T
  Biochemistry. 2000
  PubMed ID: 10757985
   
  
• Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal imprinted region of mouse chromosome 7.
  Kato R, Shirohzu H, Yokomine T, Mizuno S, Mukai T, Sasaki H
  DNA Res. 1999
  PubMed ID: 10691133
   
  
• Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation.
  Tanaka M, Puchyr M, Gertsenstein M, Harpal K, Jaenisch R, Rossant J, Nagy A
  Mech Dev. 1999
  PubMed ID: 10495277
   
  
• Developmental potential of mouse primordial germ cells.
  Kato Y, Rideout WM, Hilton K, Barton SC, Tsunoda Y, Surani MA
  Development. 1999
  PubMed ID: 10101117
   
  
• The imprinted domain in mouse distal Chromosome 7: reagents for mutagenesis and sequencing.
  Day CD, Smilinich NJ, Fitzpatrick GV, deJong PJ, Shows TB, Higgins MJ
  Mamm Genome. 1999
  PubMed ID: 9922400
   
  
• The sins of the fathers and mothers: genomic imprinting in mammalian development.
  Tilghman SM
  Cell. 1999
  PubMed ID: 9988214
   
  
• Retinoid X receptors are essential for early mouse development and placentogenesis.
  Wendling O, Chambon P, Mark M
  Proc Natl Acad Sci U S A. 1999
  PubMed ID: 9892670
   
  
• Placental failure in mice lacking the homeobox gene Dlx3.
  Morasso MI, Grinberg A, Robinson G, Sargent TD, Mahon KA
  Proc Natl Acad Sci U S A. 1999
  PubMed ID: 9874789
   
  
• High-efficiency full-length cDNA cloning.
  Carninci P, Hayashizaki Y
  Methods Enzymol. 1999
  PubMed ID: 10349636
   
  
• Mechanism of imprinting on mouse distal chromosome 7.
  Ainscough JF, John RM, Surani MA
  Genet Res. 1998
  PubMed ID: 10036981
   
  
• Requirement of the mouse I-mfa gene for placental development and skeletal patterning.
  Kraut N, Snider L, Chen CM, Tapscott SJ, Groudine M
  EMBO J. 1998
  PubMed ID: 9799236
   
  
• High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.
  Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I, Ho A, Wakeham A, Itie A, Khoo W, Fukumoto M, Mak TW
  Curr Biol. 1998
  PubMed ID: 9799734
   
  
• Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice.
  Bilinski P, Roopenian D, Gossler A
  Genes Dev. 1998
  PubMed ID: 9679067
   
  
• The transition to endoreduplication in trophoblast giant cells is regulated by the mSNA zinc finger transcription factor.
  Nakayama H, Scott IC, Cross JC
  Dev Biol. 1998
  PubMed ID: 9676199
   
  
• Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5.
  Paulsen M, Davies KR, Bowden LM, Villar AJ, Franck O, Fuermann M, Dean WL, Moore TF, Rodrigues N, Davies KE, Hu RJ, Feinberg AP, Maher ER, Reik W, Walter J
  Hum Mol Genet. 1998
  PubMed ID: 9618174
   
  
• Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster.
  Caspary T, Cleary MA, Baker CC, Guan XJ, Tilghman SM
  Mol Cell Biol. 1998
  PubMed ID: 9584186
   
  
• Mash2 is expressed in oogenesis and preimplantation development but is not required for blastocyst formation.
  Rossant J, Guillemot F, Tanaka M, Latham K, Gertenstein M, Nagy A
  Mech Dev. 1998
  PubMed ID: 9622625
   
  
• Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues.
  Dragatsis I, Efstratiadis A, Zeitlin S
  Development. 1998
  PubMed ID: 9502734
   
  
• The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice.
  Yang X, Li C, Xu X, Deng C
  Proc Natl Acad Sci U S A. 1998
  PubMed ID: 9520423
   
  
• The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis.
  Riley P, Anson-Cartwright L, Cross JC
  Nat Genet. 1998
  PubMed ID: 9500551
   
  
• Imprinting of mouse Kvlqt1 is developmentally regulated.
  Gould TD, Pfeifer K
  Hum Mol Genet. 1998
  PubMed ID: 9467008
   
  
• Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.
  Xu X, Weinstein M, Li C, Naski M, Cohen RI, Ornitz DM, Leder P, Deng C
  Development. 1998
  PubMed ID: 9435295
   
  
• A SacII polymorphism in the human ASCL2 (HASH2) gene region.
  Miyamoto T, Jinno Y, Miura K, Sengoku K, Soejima H, Yun K, Yaginuma Y, Niikawa N, Ishikawa M
  J Hum Genet. 1998
  PubMed ID: 9610003
   
  
• The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo.
  Sirard C, de la Pompa JL, Elia A, Itie A, Mirtsos C, Cheung A, Hahn S, Wakeham A, Schwartz L, Kern SE, Rossant J, Mak TW
  Genes Dev. 1998
  PubMed ID: 9420335
   
  
• Mash2 acts cell autonomously in mouse spongiotrophoblast development.
  Tanaka M, Gertsenstein M, Rossant J, Nagy A
  Dev Biol. 1997
  PubMed ID: 9331331
   
  
• Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta.
  Luo J, Sladek R, Bader JA, Matthyssen A, Rossant J, Giguère V
  Nature. 1997
  PubMed ID: 9285590
   
  
• Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome.
  Reik W, Maher ER
  Trends Genet. 1997
  PubMed ID: 9260520
   
  
• The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts.
  Alders M, Hodges M, Hadjantonakis AK, Postmus J, van Wijk I, Bliek J, de Meulemeester M, Westerveld A, Guillemot F, Oudejans C, Little P, Mannens M
  Hum Mol Genet. 1997
  PubMed ID: 9175731
   
  
• Brca2 is required for embryonic cellular proliferation in the mouse.
  Suzuki A, de la Pompa JL, Hakem R, Elia A, Yoshida R, Mo R, Nishina H, Chuang T, Wakeham A, Itie A, Koo W, Billia P, Ho A, Fukumoto M, Hui CC, Mak TW
  Genes Dev. 1997
  PubMed ID: 9171369
   
  
• Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway.
  Nakayama H, Liu Y, Stifani S, Cross JC
  Dev Genet. 1997
  PubMed ID: 9291577
   
  
• The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.
  Hakem R, de la Pompa JL, Sirard C, Mo R, Woo M, Hakem A, Wakeham A, Potter J, Reitmair A, Billia F, Firpo E, Hui CC, Roberts J, Rossant J, Mak TW
  Cell. 1996
  PubMed ID: 8674108
   
  
• Genomic cloning and localization to chromosome 11p15.5 of the human achaete-scute homolog 2 (ASCL2).
  Miyamoto T, Jinno Y, Sasaki T, Ikeda Y, Masuzaki H, Niikawa N, Ishikawa M
  Cytogenet Cell Genet. 1996
  PubMed ID: 8751384
   
  
• Mouse embryos with paternal duplication of an imprinted chromosome 7 region die at midgestation and lack placental spongiotrophoblast.
  McLaughlin KJ, Szabó P, Haegel H, Mann JR
  Development. 1996
  PubMed ID: 8565838
   
  
• Lack of beta-catenin affects mouse development at gastrulation.
  Haegel H, Larue L, Ohsugi M, Fedorov L, Herrenknecht K, Kemler R
  Development. 1995
  PubMed ID: 8582267
   
  
• An enhancer deletion affects both H19 and Igf2 expression.
  Leighton PA, Saam JR, Ingram RS, Stewart CL, Tilghman SM
  Genes Dev. 1995
  PubMed ID: 7544754
   
  
• Genomic imprinting of Mash2, a mouse gene required for trophoblast development.
  Guillemot F, Caspary T, Tilghman SM, Copeland NG, Gilbert DJ, Jenkins NA, Anderson DJ, Joyner AL, Rossant J, Nagy A
  Nat Genet. 1995
  PubMed ID: 7773285
   
  
• Analysis of the role of basic-helix-loop-helix transcription factors in the development of neural lineages in the mouse.
  Guillemot F
  Biol Cell. 1995
  PubMed ID: 8574196
   
  
• Essential role of Mash-2 in extraembryonic development.
  Guillemot F, Nagy A, Auerbach A, Rossant J, Joyner AL
  Nature. 1994
  PubMed ID: 8090202
   
  
• Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system.
  Guillemot F, Joyner AL
  Mech Dev. 1993
  PubMed ID: 8217843
   
  
• Induction and repression of mammalian achaete-scute homologue (MASH) gene expression during neuronal differentiation of P19 embryonal carcinoma cells.
  Johnson JE, Zimmerman K, Saito T, Anderson DJ
  Development. 1992
  PubMed ID: 1576967
   
  
• Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors.
  Johnson JE, Birren SJ, Anderson DJ
  Nature. 1990
  PubMed ID: 2392153
   
  
• A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner.
  Bastian H, Gruss P
  EMBO J. 1990
  PubMed ID: 1971786
   
  

Relevant resources:

Comment on this Page
Privacy Statement  |   Copyright, Warranty & Disclaimer  |   Contact Us
Copyright © 2001-2011, T1DBase | Version 4.8 | PMID:20937630
Printed on Sun February 05, 2012