MLH1

Summary Top Help

Gene Description:

mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); mutL homolog 1 (E. coli)

Synonyms:

HNPCC, COCA2, AI325952, MLH1, AI561766, HNPCC2, FCC2, Mlh1, 1110035C23Rik, AI317206, hMLH1

Orthologs:

Human MLH1 (protein-coding), Mouse Mlh1 (protein-coding), Rat Mlh1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr3:37034823..37107380 (72.56 kb) View in Genome Browser

(Mouse) NCBIM37 - chr9:111130732..111174112 (43.38 kb) View in Genome Browser

(Rat) RGSC3.4 - chr8:115616396..115653471 (378 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for MLH1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for MLH1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 4

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 34

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 779

14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif.
Andersen SD, Keijzers G, Rampakakis E, Engels K, Luhn P, El-Shemerly M, Nielsen FC, Du Y, May A, Bohr VA, Ferrari S, Zannis-Hadjopoulos M, Fu H, Rasmussen LJ
DNA Repair (Amst). 2012
PubMed ID: 22222486
"Null pattern" of immunoreactivity in a Lynch syndrome-associated colon cancer due to germline MSH2 mutation and somatic MLH1 hypermethylation.
Hagen CE, Lefferts J, Hornick JL, Srivastava A
Am J Surg Pathol. 2011
PubMed ID: 22067334
ATM controls meiotic double-strand-break formation.
Lange J, Pan J, Cole F, Thelen MP, Jasin M, Keeney S
Nature. 2011
PubMed ID: 22002603
A novel exonic rearrangement affecting MLH1 and the contiguous LRRFIP2 is a founder mutation in Portuguese Lynch syndrome families.
Pinheiro M, Pinto C, Peixoto A, Veiga I, Mesquita B, Henrique R, Baptista M, Fragoso M, Sousa O, Pereira H, Marinho C, Moreira Dias L, Teixeira MR
Genet Med. 2011
PubMed ID: 21785361
Promoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma-carcinoma sequence.
Lee KH, Lee JS, Nam JH, Choi C, Lee MC, Park CS, Juhng SW, Lee JH
Langenbecks Arch Surg. 2011
PubMed ID: 21706233
Aberrant methylation of different DNA repair genes demonstrates distinct prognostic value for esophageal cancer.
Ling ZQ, Li P, Ge MH, Hu FJ, Fang XH, Dong ZM, Mao WM
Dig Dis Sci. 2011
PubMed ID: 21674174
Microsatellite instability in young patients with sporadic colorectal adenomas.
Park SK, Park DI, Park SH, Park JH, Kim HJ, Cho YK, Sohn CI, Jeon WK, Kim BI, Kim MK, Ji JS, Park SJ, Han DS
Hepatogastroenterology. 2011
PubMed ID: 22086685
The association between MLH1 -93 G>A polymorphism of DNA mismatch repair and cancer susceptibility: a meta-analysis.
Pan XM, Yang WZ, Xu GH, Bai P, Qin HJ, Zhang LS, Zhai XD, Tang M, Deng W, Zhang L, Gao LB
Mutagenesis. 2011
PubMed ID: 21745804
Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5'UTR.
Hitchins MP, Rapkins RW, Kwok CT, Srivastava S, Wong JJ, Khachigian LM, Polly P, Goldblatt J, Ward RL
Cancer Cell. 2011
PubMed ID: 21840485
Mismatch repair genes expression defects & association with clinicopathological characteristics in colorectal carcinoma.
Kaur G, Masoud A, Raihan N, Radzi M, Khamizar W, Kam LS
Indian J Med Res. 2011
PubMed ID: 21911971
Biallelic MLH1 SNP cDNA expression or constitutional promoter methylation can hide genomic rearrangements causing Lynch syndrome.
Morak M, Koehler U, Schackert HK, Steinke V, Royer-Pokora B, Schulmann K, Kloor M, Höchter W, Weingart J, Keiling C, Massdorf T, Holinski-Feder E, German HNPCC consortium
J Med Genet. 2011
PubMed ID: 21712435
Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis.
Le Masson F, Razak Z, Kaigo M, Audouard C, Charry C, Cooke H, Westwood JT, Christians ES
Mol Cell Biol. 2011
PubMed ID: 21690297
MLH1-93G > A is a risk factor for MSI colorectal cancer.
Whiffin N, Broderick P, Lubbe SJ, Pittman AM, Penegar S, Chandler I, Houlston RS
Carcinogenesis. 2011
PubMed ID: 21565826
Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas.
Felsberg J, Thon N, Eigenbrod S, Hentschel B, Sabel MC, Westphal M, Schackert G, Kreth FW, Pietsch T, Löffler M, Weller M, Reifenberger G, Tonn JC, German Glioma Network
Int J Cancer. 2011
PubMed ID: 21425258
Aberrant methylation of hMLH1 and p16INK4a in Tunisian patients with sporadic colorectal adenocarcinoma.
Miladi-Abdennadher I, Abdelmaksoud-Damak R, Ayadi L, Khabir A, Frikha F, Kallel L, Frikha M, Sellami-Boudawara T, Gargouri A, Mokdad-Gargouri R
Biosci Rep. 2011
PubMed ID: 20815811
Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes.
Win AK, Dowty JG, English DR, Campbell PT, Young JP, Winship I, Macrae FA, Lipton L, Parry S, Young GP, Buchanan DD, Martínez ME, Jacobs ET, Ahnen DJ, Haile RW, Casey G, Baron JA, Lindor NM, Thibodeau SN, Newcomb PA, Potter JD, Le Marchand L, Gallinger S, Hopper JL, Jenkins MA
Br J Cancer. 2011
PubMed ID: 21559014
Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome.
Bonadona V, Bonaïti B, Olschwang S, Grandjouan S, Huiart L, Longy M, Guimbaud R, Buecher B, Bignon YJ, Caron O, Colas C, Noguès C, Lejeune-Dumoulin S, Olivier-Faivre L, Polycarpe-Osaer F, Nguyen TD, Desseigne F, Saurin JC, Berthet P, Leroux D, Duffour J, Manouvrier S, Frébourg T, Sobol H, Lasset C, Bonaïti-Pellié C, French Cancer Genetics Network
JAMA. 2011
PubMed ID: 21642682
Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis.
Holloway JK, Mohan S, Balmus G, Sun X, Modzelewski A, Borst PL, Freire R, Weiss RS, Cohen PE
PLoS Genet. 2011
PubMed ID: 21655083
EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1.
Geddert H, zur Hausen A, Gabbert HE, Sarbia M
Cell Oncol (Dordr). 2011
PubMed ID: 21538028
Missense variants in hMLH1 identified in patients from the German HNPCC consortium and functional studies.
Hardt K, Heick SB, Betz B, Goecke T, Yazdanparast H, Küppers R, Servan K, Steinke V, Rahner N, Morak M, Holinski-Feder E, Engel C, Möslein G, Schackert HK, von Knebel Doeberitz M, Pox C, Peter Propping, German HNPCC consortium, Hegemann JH, Royer-Pokora B
Fam Cancer. 2011
PubMed ID: 21404117
Non-truncating hMLH1 variants identified in Slovenian gastric cancer patients are not associated with Lynch Syndrome: a functional analysis report.
Vogelsang M, Komel R
Fam Cancer. 2011
PubMed ID: 21136174
Polymorphisms of MLH1 and MSH2 genes and the risk of lung cancer among never smokers.
Lo YL, Hsiao CF, Jou YS, Chang GC, Tsai YH, Su WC, Chen KY, Chen YM, Huang MS, Hsieh WS, Chen CJ, Hsiung CA
Lung Cancer. 2011
PubMed ID: 21093954
A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility.
Schramm S, Fraune J, Naumann R, Hernandez-Hernandez A, Höög C, Cooke HJ, Alsheimer M, Benavente R
PLoS Genet. 2011
PubMed ID: 21637789
Distinct mutations in MLH1 and MSH2 genes in hereditary non-polyposis colorectal cancer (HNPCC) families from China.
Wei W, Liu F, Liu L, Li Z, Zhang X, Jiang F, Shi Q, Zhou X, Sheng W, Cai S, Li X, Xu Y, Nan P
BMB Rep. 2011
PubMed ID: 21615986
Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.
Daniel K, Lange J, Hached K, Fu J, Anastassiadis K, Roig I, Cooke HJ, Stewart AF, Wassmann K, Jasin M, Keeney S, Tóth A
Nat Cell Biol. 2011
PubMed ID: 21478856
Gene expression profile and mutational analysis of DNA mismatch repair genes in carcinoma prostate in Indian population.
Soni A, Bansal A, Singh LC, Mishra AK, Majumdar M, Regina T, Mohanty NK, Saxena S
OMICS. 2011
PubMed ID: 21348638
Oocyte-specific differences in cell-cycle control create an innate susceptibility to meiotic errors.
Nagaoka SI, Hodges CA, Albertini DF, Hunt PA
Curr Biol. 2011
PubMed ID: 21497085
Microsatellite instability and promoter hypermethylation of MLH1 and MSH2 in patients with sporadic colorectal cancer.
Vlaykova T, Mitkova A, Stancheva G, Kadiyska T, Gulubova M, Yovchev Y, Cirovski G, Chilingirov P, Damyanov D, Kremensky I, Mitev V, Kaneva R
J BUON. 2011
PubMed ID: 21766496
14-3-3 Proteins regulate exonuclease 1-dependent processing of stalled replication forks.
Engels K, Giannattasio M, Muzi-Falconi M, Lopes M, Ferrari S
PLoS Genet. 2011
PubMed ID: 21533173
Molecular analysis of Fanconi anemia and mismatch repair genes in patients with colorectal carcinoma.
Colombino M, Avallone A, Izzo F, Tatangelo F, Budroni M, Cossu A, Galimi F, Comella P, Botti G, Sini MC, Tanda F, Palmieri G, Southern Italy Cooperative Oncology Group
Oncol Rep. 2011
PubMed ID: 21286667
MSI phenotype and MMR alterations in familial and sporadic gastric cancer.
Leite M, Corso G, Sousa S, Milanezi F, Afonso LP, Henrique R, Soares JM, Castedo S, Carneiro F, Roviello F, Oliveira C, Seruca R
Int J Cancer. 2011
PubMed ID: 20533283
Intensity-dependent constitutional MLH1 promoter methylation leads to early onset of colorectal cancer by affecting both alleles.
Auclair J, Vaissière T, Desseigne F, Lasset C, Bonadona V, Giraud S, Saurin JC, Joly MO, Leroux D, Faivre L, Audoynaud C, Montmain G, Ruano E, Herceg Z, Puisieux A, Wang Q
Genes Chromosomes Cancer. 2011
PubMed ID: 21213371
Functional effects of the MLH1-93G>A polymorphism on MLH1/EPM2AIP1 promoter activity.
Perera S, Mrkonjic M, Rawson JB, Bapat B
Oncol Rep. 2011
PubMed ID: 21206982
Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer.
Wong JJ, Hawkins NJ, Ward RL, Hitchins MP
Mod Pathol. 2011
PubMed ID: 21102416
Expression of DNA repair proteins, MSH2, MLH1 and MGMT in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients' survival.
Theocharis S, Klijanienko J, Giaginis C, Rodriguez J, Jouffroy T, Girod A, Point D, Tsourouflis G, Sastre-Garau X
J Oral Pathol Med. 2011
PubMed ID: 21029181
An intronic mutation in MLH1 associated with familial colon and breast cancer.
Bianchi F, Raponi M, Piva F, Viel A, Bearzi I, Galizia E, Bracci R, Belvederesi L, Loretelli C, Brugiati C, Corradini F, Baralle D, Cellerino R
Fam Cancer. 2011
PubMed ID: 20717847
Expression of DNA repair proteins MSH2, MLH1 and MGMT in human benign and malignant thyroid lesions: an immunohistochemical study.
Giaginis C, Michailidi C, Stolakis V, Alexandrou P, Tsourouflis G, Klijanienko J, Delladetsima I, Theocharis S
Med Sci Monit. 2011
PubMed ID: 21358597
The host genetic background of DNA repair mechanisms is an independent predictor of survival in diffuse large B-cell lymphoma.
Rossi D, Rasi S, Di Rocco A, Fabbri A, Forconi F, Gloghini A, Bruscaggin A, Franceschetti S, Fangazio M, De Paoli L, Bruna R, Capello D, Chiappella A, Lobetti Bodoni C, Giachelia M, Tisi MC, Pogliani EM, Lauria F, Ladetto M, Hohaus S, Martelli M, Vitolo U, Carbone A, Foà R, Gaidano G
Blood. 2011
PubMed ID: 21156845
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome.
Suhasini AN, Rawtani NA, Wu Y, Sommers JA, Sharma S, Mosedale G, North PS, Cantor SB, Hickson ID, Brosh RM
EMBO J. 2011
PubMed ID: 21240188
Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining.
Eccleston J, Yan C, Yuan K, Alt FW, Selsing E
J Immunol. 2011
PubMed ID: 21242524
De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one.
Goel A, Nguyen TP, Leung HC, Nagasaka T, Rhees J, Hotchkiss E, Arnold M, Banerji P, Koi M, Kwok CT, Packham D, Lipton L, Boland CR, Ward RL, Hitchins MP
Int J Cancer. 2011
PubMed ID: 20473912
Novel MLH1 duplication identified in Colombian families with Lynch syndrome.
Alonso-Espinaco V, Giráldez MD, Trujillo C, van der Klift H, Muñoz J, Balaguer F, Ocaña T, Madrigal I, Jones AM, Echeverry MM, Velez A, Tomlinson I, Milà M, Wijnen J, Carvajal-Carmona L, Castells A, Castellví-Bel S
Genet Med. 2011
PubMed ID: 21233718
MLH1 function is context dependent in colorectal cancers.
Jackson T, Ahmed MA, Seth R, Jackson D, Ilyas M
J Clin Pathol. 2011
PubMed ID: 21169277
Endometrial cancer and genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2 within a population-based case-control study.
Lacey JV, Yang H, Gaudet MM, Dunning A, Lissowska J, Sherman ME, Peplonska B, Brinton LA, Healey CS, Ahmed S, Pharoah P, Easton D, Chanock S, Garcia-Closas M
Gynecol Oncol. 2011
PubMed ID: 21093899
Spreading of Alu methylation to the promoter of the MLH1 gene in gastrointestinal cancer.
Wang X, Fan J, Liu D, Fu S, Ingvarsson S, Chen H
PLoS One. 2011
PubMed ID: 22022465
MLH1 promoter methylation, diet, and lifestyle factors in mismatch repair deficient colorectal cancer patients from EPIC-Norfolk.
Gay LJ, Arends MJ, Mitrou PN, Bowman R, Ibrahim AE, Happerfield L, Luben R, McTaggart A, Ball RY, Rodwell SA
Nutr Cancer. 2011
PubMed ID: 21875327
Inactivation of COX-2, HMLH1 and CDKN2A gene by promoter methylation in gastric cancer: relationship with histological subtype, tumor location and Helicobacter pylori genotype.
Alves MK, Ferrasi AC, Lima VP, Ferreira MV, de Moura Campos Pardini MI, Rabenhorst SH
Pathobiology. 2011
PubMed ID: 21849808
Promoter methylation of p16(INK4A), hMLH1, and MGMT in liquid-based cervical cytology samples compared with clinicopathological findings and HPV presence.
Spathis A, Aga E, Alepaki M, Chranioti A, Meristoudis C, Panayiotides I, Kassanos D, Karakitsos P
Infect Dis Obstet Gynecol. 2011
PubMed ID: 21747645
Prognostic value of H-MLH1 after adjusting for RPA class in GBM patients.
Choucair A, Moughan J, Schultz C, Schulsinger A, Mehta M, Curran W
Front Biosci (Elite Ed). 2011
PubMed ID: 21622124
Diet folate, DNA methylation and genetic polymorphisms of MTHFR C677T in association with the prognosis of esophageal squamous cell carcinoma.
Lu C, Xie H, Wang F, Shen H, Wang J
BMC Cancer. 2011
PubMed ID: 21375764
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
hMLH1 promoter methylation is an early event in oral cancer.
González-Ramírez I, Ramírez-Amador V, Irigoyen-Camacho ME, Sánchez-Pérez Y, Anaya-Saavedra G, Granados-García M, García-Vázquez F, García-Cuellar CM
Oral Oncol. 2011
PubMed ID: 21075045
[Association of mismatch repair gene polymorphism with susceptibility to sporadic colorectal cancer in Tianjin region].
Li HC, Feng HY, Zhang XP, Liu R, Ma DW, Qin H, Zhou Y, Yu L
Yi Chuan. 2010
PubMed ID: 21513149
Racial differences in MLH1 and MSH2 mutation: an analysis of yellow race and white race based on the InSiGHT database.
Wei W, Liu L, Chen J, Jin K, Jiang F, Liu F, Fan R, Cheng Z, Shen M, Xue C, Cai S, Xu Y, Nan P
J Bioinform Comput Biol. 2010
PubMed ID: 21155023
Immunohistochemical expression of mismatch repair genes (hMSH2 and hMLH1) in hepatocellular carcinoma in Egypt.
Helal TE, Khamis NS, El-Sharkawy TM, Nada OH, Radwan NA
APMIS. 2010
PubMed ID: 21091774
Magnetic resonance colonography for colorectal cancer screening in patients with Lynch syndrome gene mutation.
Lim EJ, Leung C, Pitman A, Stella DL, Brown G, Slattery M, Marion K, Macrae F
Fam Cancer. 2010
PubMed ID: 20495877
Microsatellite instability with promoter methylation and silencing of hMLH1 can regionally occur during progression of gastric carcinoma.
Ling ZQ, Tanaka A, Li P, Nakayama T, Fujiyama Y, Hattori T, Sugihara H
Cancer Lett. 2010
PubMed ID: 20831982
Conservation of functional asymmetry in the mammalian MutLα ATPase.
Johnson JR, Erdeniz N, Nguyen M, Dudley S, Liskay RM
DNA Repair (Amst). 2010
PubMed ID: 20864418
Rapid Development of Colorectal Neoplasia in Patients With Lynch Syndrome.
Edelstein DL, Axilbund J, Baxter M, Hylind LM, Romans K, Griffin CA, Cruz-Correa M, Giardiello FM
Clin Gastroenterol Hepatol. 2010
PubMed ID: 21070872
DNA Mismatch Repair Gene Alterations in a Population-based Sample of Young-onset Colorectal Cancer Patients.
Limburg PJ, Harmsen WS, Chen HH, Gallinger S, Haile RW, Baron JA, Casey G, Woods MO, Thibodeau SN, Lindor NM
Clin Gastroenterol Hepatol. 2010
PubMed ID: 21056691
An MLH1 mutation links BACH1/FANCJ to colon cancer, signaling, and insight toward directed therapy.
Xie J, Guillemette S, Peng M, Gilbert C, Buermeyer A, Cantor SB
Cancer Prev Res (Phila). 2010
PubMed ID: 20978114
MLH1 Differential allelic expression in mutation carriers and controls.
Santibanez Koref M, Wilson V, Cartwright N, Cunnington MS, Mathers JC, Bishop DT, Curtis A, Dunlop MG, Burn J
Ann Hum Genet. 2010
PubMed ID: 20860725
Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer.
Kim M, Kang HG, Lee SY, Lee HC, Lee EB, Choi YY, Lee WK, Cho S, Jin G, Jheon HS, Son JW, Lee MH, Jung DK, Cha SI, Kim CH, Kang YM, Kam S, Jung TH, Jheon S, Park JY
Cancer Sci. 2010
PubMed ID: 20731661
Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.
Qi Y, Schoene NW, Lartey FM, Cheng WH
J Biol Chem. 2010
PubMed ID: 20709753
Three novel germline mutations in MLH1 and MSH2 in families with Lynch syndrome living on Jeju island, Korea.
Kim YM, Choe CG, Cho SK, Jung IH, Chang WY, Cho M
BMB Rep. 2010
PubMed ID: 21034533
MLH1 founder mutations with moderate penetrance in Spanish Lynch syndrome families.
Borràs E, Pineda M, Blanco I, Jewett EM, Wang F, Teulé A, Caldés T, Urioste M, Martínez-Bouzas C, Brunet J, Balmaña J, Torres A, Ramón y Cajal T, Sanz J, Pérez-Cabornero L, Castellví-Bel S, Alonso A, Lanas A, González S, Moreno V, Gruber SB, Rosenberg NA, Mukherjee B, Lázaro C, Capellá G
Cancer Res. 2010
PubMed ID: 20858721
Conditional inactivation of MLH1 in thymic and naive T-cells in mice leads to a limited incidence of lymphoblastic T-cell lymphomas.
Reiss C, Haneke T, Völker HU, Spahn M, Rosenwald A, Edelmann W, Kneitz B
Leuk Lymphoma. 2010
PubMed ID: 20858091
Microsatellite instability and hMLH1 and hMSH2 expression in renal tumors.
Altavilla G, Fassan M, Busatto G, Orsolan M, Giacomelli L
Oncol Rep. 2010
PubMed ID: 20811672
Immunoexpression and clinical significance of the PTEN and MLH1 proteins in endometrial carcinomas.
Bąkiewicz A, Michalak J, Sporny S
Pol J Pathol. 2010
PubMed ID: 21290340
Lynch syndrome: the influence of environmental factors on extracolonic cancer risk in hMLH1 c.C1528T mutation carriers and their mutation-negative sisters.
Blokhuis MM, Pietersen GE, Goldberg PA, Algar U, Van der Merwe L, Mbatani N, Vorster AA, Ramesar RS
Fam Cancer. 2010
PubMed ID: 20640520
Analysis of mismatch repair gene mutations in Turkish HNPCC patients.
Tunca B, Pedroni M, Cecener G, Egeli U, Borsi E, Zorluoglu A, Di Gregorio C, Yilmazlar T, Yerci O, de Leon MP
Fam Cancer. 2010
PubMed ID: 20373145
Location-related differences in sporadic microsatellite unstable colorectal cancer.
Cho YK, Kim HC, Kim SH, Park JH, Yun HR, Cho YB, Yun SH, Lee WY, Chun HK
Dig Liver Dis. 2010
PubMed ID: 20227930
Detection of allelic imbalance in MLH1 expression by pyrosequencing serves as a tool for the identification of germline defects in Lynch syndrome.
Kwok CT, Ward RL, Hawkins NJ, Hitchins MP
Fam Cancer. 2010
PubMed ID: 20063070
Association between Genetic Polymorphisms in the XRCC1, XRCC3, XPD, GSTM1, GSTT1, MSH2, MLH1, MSH3, and MGMT Genes and Radiosensitivity in Breast Cancer Patients.
Mangoni M, Bisanzi S, Carozzi F, Sani C, Biti G, Livi L, Barletta E, Costantini AS, Gorini G
Int J Radiat Oncol Biol Phys. 2010
PubMed ID: 20708344
[Expression and significance of mismatch repair genes hMLH1 and hMSH2 in sporadic colorectal carcinoma].
Zheng JY, Ren TS, Liu B, Wang MN, Liao HH
Zhonghua Zhong Liu Za Zhi. 2010
PubMed ID: 21122410
Estrogen stimulates the expression of mismatch repair gene hMLH1 in colonic epithelial cells.
Jin P, Lu XJ, Sheng JQ, Fu L, Meng XM, Wang X, Shi TP, Li SR, Rao J
Cancer Prev Res (Phila). 2010
PubMed ID: 20663978
Identification of Lynch syndrome mutations in the MLH1-PMS2 interface that disturb dimerization and mismatch repair.
Kosinski J, Hinrichsen I, Bujnicki JM, Friedhoff P, Plotz G
Hum Mutat. 2010
PubMed ID: 20533529
hMLH1 promoter methylation and JC virus T antigen presence in the tumor tissue of colorectal cancer Israeli patients of different ethnic groups.
Niv Y, Vilkin A, Brenner B, Kendel Y, Morgenstern S, Levi Z
Eur J Gastroenterol Hepatol. 2010
PubMed ID: 20531010
A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.
Ho-Pun-Cheung A, Assenat E, Bascoul-Mollevi C, Bibeau F, Boissière-Michot F, Thezenas S, Cellier D, Azria D, Rouanet P, Senesse P, Ychou M, Lopez-Crapez E
Pharmacogenomics J. 2010
PubMed ID: 20644561
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiácovo MP, Elledge SJ
Mol Cell. 2010
PubMed ID: 20603073
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
MacKay C, Déclais AC, Lundin C, Agostinho A, Deans AJ, MacArtney TJ, Hofmann K, Gartner A, West SC, Helleday T, Lilley DM, Rouse J
Cell. 2010
PubMed ID: 20603015
Risk of urothelial bladder cancer in Lynch syndrome is increased, in particular among MSH2 mutation carriers.
van der Post RS, Kiemeney LA, Ligtenberg MJ, Witjes JA, Hulsbergen-van de Kaa CA, Bodmer D, Schaap L, Kets CM, van Krieken JH, Hoogerbrugge N
J Med Genet. 2010
PubMed ID: 20591884
Role of methylation of the hMLH1 gene promoter in the development of gastric and colorectal carcinoma in the elderly.
Arai T, Kasahara I, Sawabe M, Honma N, Aida J, Tabubo K
Geriatr Gerontol Int. 2010
PubMed ID: 20590835
Methylation analysis of MLH1 improves the selection of patients for genetic testing in Lynch syndrome.
Pérez-Carbonell L, Alenda C, Payá A, Castillejo A, Barberá VM, Guillén C, Rojas E, Acame N, Gutiérrez-Aviñó FJ, Castells A, Llor X, Andreu M, Soto JL, Jover R
J Mol Diagn. 2010
PubMed ID: 20489114
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.
Hawken SJ, Greenwood CM, Hudson TJ, Kustra R, McLaughlin J, Yang Q, Zanke BW, Little J
Hum Genet. 2010
PubMed ID: 20437058
CHEK2 mutations and HNPCC-related colorectal cancer.
Suchy J, Cybulski C, Wokołorczyk D, Oszurek O, Górski B, Debniak T, Jakubowska A, Gronwald J, Huzarski T, Byrski T, Dziuba I, Gogacz M, Wiśniowski R, Wandzel P, Banaszkiewicz Z, Kurzawski G, Kładny J, Narod SA, Lubiński J
Int J Cancer. 2010
PubMed ID: 19876921
Frequent alterations of the candidate genes hMLH1, ITGA9 and RBSP3 in early dysplastic lesions of head and neck: clinical and prognostic significance.
Ghosh A, Ghosh S, Maiti GP, Sabbir MG, Zabarovsky ER, Roy A, Roychoudhury S, Panda CK
Cancer Sci. 2010
PubMed ID: 20412120
Evaluation of in vivo liver genotoxic potential of Wy-14,643 and piperonyl butoxide in rats subjected to two-week repeated oral administration.
Suzuki T, Jin M, Dewa Y, Ichimura R, Shimada Y, Mizukami S, Shibutani M, Mitsumori K
Arch Toxicol. 2010
PubMed ID: 20127075
Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.
Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J
Breast Cancer Res Treat. 2010
PubMed ID: 20496165
Polymorphisms in hMSH2 and hMLH1 and response to platinum-based chemotherapy in advanced non-small-cell lung cancer patients.
Cheng H, Sun N, Sun X, Chen B, Li F, Feng J, Cheng L, Cao Y
Acta Biochim Biophys Sin (Shanghai). 2010
PubMed ID: 20458443
Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB
Cancer Prev Res (Phila Pa). 2010
PubMed ID: 20403997
Immunophenotypic evaluation of DNA mismatch repair markers in 2 cases of synchronous histomorphologically distinct gastric adenocarcinomas with gastrointestinal stromal tumors of the proximal small bowel.
Athanassiou E, Vamvakopoulou DN, Zacharoulis D, Paroutoglou G, Sioutopoulou D, Tepetes K, Nomikos I, Vamvakopoulos NC
Appl Immunohistochem Mol Morphol. 2010
PubMed ID: 20090515
Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.
Loizidou MA, Cariolou MA, Neuhausen SL, Newbold RF, Bashiardes E, Marcou Y, Michael T, Daniel M, Kakouri E, Papadopoulos P, Malas S, Hadjisavvas A, Kyriacou K
Breast Cancer Res Treat. 2010
PubMed ID: 19714462
Targeting the FANCJ-BRCA1 interaction promotes a switch from recombination to poleta-dependent bypass.
Xie J, Litman R, Wang S, Peng M, Guillemette S, Rooney T, Cantor SB
Oncogene. 2010
PubMed ID: 20173781
Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy.
Cecchin E, Agostini M, Pucciarelli S, De Paoli A, Canzonieri V, Sigon R, De Mattia E, Friso ML, Biason P, Visentin M, Nitti D, Toffoli G
Pharmacogenomics J. 2010
PubMed ID: 20368715
RAD51D protects against MLH1-dependent cytotoxic responses to O(6)-methylguanine.
Rajesh P, Rajesh C, Wyatt MD, Pittman DL
DNA Repair (Amst). 2010
PubMed ID: 20133210
Effects of calcium and vitamin D on MLH1 and MSH2 expression in rectal mucosa of sporadic colorectal adenoma patients.
Sidelnikov E, Bostick RM, Flanders WD, Long Q, Fedirko V, Shaukat A, Daniel CR, Rutherford RE
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20332274
Spectrum of MLH1 and MSH2 mutations in Chilean families with suspected Lynch syndrome.
Alvarez K, Hurtado C, Hevia MA, Wielandt AM, de la Fuente M, Church J, Carvallo P, López-Köstner F
Dis Colon Rectum. 2010
PubMed ID: 20305446
Common variants in human CRC genes as low-risk alleles.
Picelli S, Zajac P, Zhou XL, Edler D, Lenander C, Dalén J, Hjern F, Lundqvist N, Lindforss U, Påhlman L, Smedh K, Törnqvist A, Holm J, Janson M, Andersson M, Ekelund S, Olsson L, Lundeberg J, Lindblom A
Eur J Cancer. 2010
PubMed ID: 20149637
One to 2-Year Surveillance Intervals Reduce Risk of Colorectal Cancer in Families With Lynch Syndrome.
Vasen HF, Abdirahman M, Brohet R, Langers AM, Kleibeuker JH, Kouwen MV, Koornstra JJ, Boot H, Cats A, Dekker E, Sanduleanu S, Poley JW, Hardwick JC, Cappel WH, Jong AE, Tan TG, Jacobs M, Mohamed FA, Boer SY, Meeberg PC, Verhulst ML, Salemans JM, Bentem NV, Westerveld BD, Vecht J, Nagengast FM
Gastroenterology. 2010
PubMed ID: 20206180
[Study on genetic polymorphism of human mismatch repair gene hMLH1 and susceptibility of papillary thyroid carcinoma in Chinese Han people]
Shi WP, Bian JC, Jiang F, Ni HX, Zhu QX, Tang HW, Shen Q, Wu Y
Zhonghua Yu Fang Yi Xue Za Zhi. 2010
PubMed ID: 20450746
[Mismatch repair gene hMLH1 A655G/A polymorphism and colorectal cancer]
Song L, Zhang XM, Wang DQ, Li JT, Ma GJ, Chen SQ, Zhou JN
Zhonghua Wei Chang Wai Ke Za Zhi. 2010
PubMed ID: 20336543
A cell-free assay for the functional analysis of variants of the mismatch repair protein MLH1.
Drost M, Zonneveld JB, van Dijk L, Morreau H, Tops CM, Vasen HF, Wijnen JT, de Wind N
Hum Mutat. 2010
PubMed ID: 20020535
Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.
Hazra A, Fuchs CS, Kawasaki T, Kirkner GJ, Hunter DJ, Ogino S
Cancer Causes Control. 2010
PubMed ID: 19936946
Alternative splicing of hMLH1 in childhood acute lymphoblastic leukaemia and characterisation of the variably expressed Delta9/10 isoform as a dominant negative species.
Peasland A, Matheson E, Hall A, Irving J
Leuk Res. 2010
PubMed ID: 19767099
A new familial gastric cancer-related gene polymorphism: T1151A in the mismatch repair gene hMLH1.
Wu J, Wang D, Song L, Li S, Ding J, Chen S, Li J, Ma G, Zhang X
Mol Biol Rep. 2010
PubMed ID: 20177793
Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage.
Mastrocola AS, Heinen CD
DNA Repair (Amst). 2010
PubMed ID: 20004149
The MLH1 -93 promoter variant influences gene expression.
Mei M, Liu D, Dong S, Ingvarsson S, Goodfellow PJ, Chen H
Cancer Epidemiol. 2010
PubMed ID: 20060799
Risk and epidemiological time trends of gastric cancer in Lynch syndrome carriers in the Netherlands.
Capelle LG, Van Grieken NC, Lingsma HF, Steyerberg EW, Klokman WJ, Bruno MJ, Vasen HF, Kuipers EJ
Gastroenterology. 2010
PubMed ID: 19900449
Microsatellite instability analysis and its correlation with hMLH1 repair gene hypermethylation status in esophageal pathologies including cancers.
Vasavi M, Kiran V, Ravishankar B, Prabhakar B, Ahuja YR, Hasan Q
Cancer Biomark. 2010
PubMed ID: 21045259
EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1.
Geddert H, Zur Hausen A, Gabbert HE, Sarbia M
Anal Cell Pathol (Amst). 2010
PubMed ID: 20978327
Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.
Mrkonjic M, Roslin NM, Greenwood CM, Raptis S, Pollett A, Laird PW, Pethe VV, Chiang T, Daftary D, Dicks E, Thibodeau SN, Gallinger S, Parfrey PS, Younghusband HB, Potter JD, Hudson TJ, McLaughlin JR, Green RC, Zanke BW, Newcomb PA, Paterson AD, Bapat B
PLoS One. 2010
PubMed ID: 20967208
Screening of the DNA mismatch repair genes MLH1, MSH2 and MSH6 in a Greek cohort of Lynch syndrome suspected families.
Thodi G, Fostira F, Sandaltzopoulos R, Nasioulas G, Grivas A, Boukovinas I, Mylonaki M, Panopoulos C, Magic MB, Fountzilas G, Yannoukakos D
BMC Cancer. 2010
PubMed ID: 20937110
Decreased transcription-coupled nucleotide excision repair capacity is associated with increased p53- and MLH1-independent apoptosis in response to cisplatin.
Stubbert LJ, Smith JM, McKay BC
BMC Cancer. 2010
PubMed ID: 20470425
Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?
van Roon EH, van Puijenbroek M, Middeldorp A, van Eijk R, de Meijer EJ, Erasmus D, Wouters KA, van Engeland M, Oosting J, Hes FJ, Tops CM, van Wezel T, Boer JM, Morreau H
BMC Cancer. 2010
PubMed ID: 20444249
DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response.
Dejeux E, Rønneberg JA, Solvang H, Bukholm I, Geisler S, Aas T, Gut IG, Børresen-Dale AL, Lønning PE, Kristensen VN, Tost J
Mol Cancer. 2010
PubMed ID: 20338046
R659X mutation in the MLH1 gene in hereditary non-polyposis colorectal cancer(HNPCC) in an Indian extended family.
Rajender S, Pooja S, Kumar MV, Karwasra R, Singh L, Thangaraj K
Indian J Med Res. 2010
PubMed ID: 20167975
Population-based study of the association of variants in mismatch repair genes with prostate cancer risk and outcomes.
Langeberg WJ, Kwon EM, Koopmeiners JS, Ostrander EA, Stanford JL
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20056646
A polymorphism in the hMLH1 gene (-93G-->A) associated with lung cancer susceptibility and prognosis.
Shih CM, Chen CY, Lee IH, Kao WT, Wang YC
Int J Mol Med. 2010
PubMed ID: 19956916
Aberrant methylation of DNA mismatch repair genes in elderly patients with sporadic gastric carcinoma: A comparison with younger patients.
Kim HG, Lee S, Kim DY, Ryu SY, Joo JK, Kim JC, Lee KH, Lee JH
J Surg Oncol. 2010
PubMed ID: 19894224
Quantitative evaluation of CpG island methylation in hyperplastic polyps.
Vaughn CP, Wilson AR, Samowitz WS
Mod Pathol. 2010
PubMed ID: 19855373
Colorectal cancer in Iran: immunohistochemical profiles of four mismatch repair proteins.
Molaei M, Mansoori BK, Ghiasi S, Khatami F, Attarian H, Zali M
Int J Colorectal Dis. 2010
PubMed ID: 19707776
Comparative in silico analyses and experimental validation of novel splice site and missense mutations in the genes MLH1 and MSH2.
Betz B, Theiss S, Aktas M, Konermann C, Goecke TO, Möslein G, Schaal H, Royer-Pokora B
J Cancer Res Clin Oncol. 2010
PubMed ID: 19669161
Embryonic lethality after combined inactivation of Fancd2 and Mlh1 in mice.
van de Vrugt HJ, Eaton L, Hanlon Newell A, Al-Dhalimy M, Liskay RM, Olson SB, Grompe M
Cancer Res. 2009
PubMed ID: 19934329
Endometrial carcinomas in women aged 40 years and younger: tumors associated with loss of DNA mismatch repair proteins comprise a distinct clinicopathologic subset.
Garg K, Shih K, Barakat R, Zhou Q, Iasonos A, Soslow RA
Am J Surg Pathol. 2009
PubMed ID: 19898223
Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial.
Braun MS, Richman SD, Thompson L, Daly CL, Meade AM, Adlard JW, Allan JM, Parmar MK, Quirke P, Seymour MT
J Clin Oncol. 2009
PubMed ID: 19858398
Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.
Yan T, Seo Y, Kinsella TJ
Clin Cancer Res. 2009
PubMed ID: 19861440
A novel interaction between human DNA polymerase eta and MutLalpha.
Kanao R, Hanaoka F, Masutani C
Biochem Biophys Res Commun. 2009
PubMed ID: 19703417
Prognostic relevance of MLH1 and MSH2 mutations in hereditary non-polyposis colorectal cancer patients.
Russo A, Sala P, Alberici P, Gazzoli I, Radice P, Montefusco C, Torrini M, Mareni C, Fornasarig M, Santarosa M, Viel A, Benatti P, Pedroni M, Pedroni M, de Leon MP, Lucci-Cordisco E, Genuardi M, Messerini L, Stigliano V, Cama A, Curia MC, de Lellis L, Signoroni S, Pierotti MA, Bertario L
Tumori. 2009
PubMed ID: 20210238
Immunohistochemical analysis of hMLH1 and hMSH2 proteins in serous ovarian tumours.
Stasikowska-Kanicka O, Stawerski P, Wagrowska-Danilewicz M, Danilewicz M
Pol J Pathol. 2009
PubMed ID: 20072951
The identification of Lynch syndrome in British Columbia.
Cremin CM, Armstrong L, Gill S, Huntsman D, Bajdik C
Can J Gastroenterol. 2009
PubMed ID: 19893772
Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations.
Itano O, Yang K, Fan K, Kurihara N, Shinozaki H, Abe S, Jin B, Gravaghi C, Edelmann W, Augenlicht L, Kopelovich L, Kucherlapati R, Lamprecht S, Lipkin M
Carcinogenesis. 2009
PubMed ID: 19755659
Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-finger motif, is involved in spermatogenesis and retrotransposon suppression in murine testes.
Yoshimura T, Toyoda S, Kuramochi-Miyagawa S, Miyazaki T, Miyazaki S, Tashiro F, Yamato E, Nakano T, Miyazaki J
Dev Biol. 2009
PubMed ID: 19735653
Calculation of risk of colorectal and endometrial cancer among patients with lynch syndrome.
Stoffel E, Mukherjee B, Raymond VM, Tayob N, Kastrinos F, Sparr J, Wang F, Bandipalliam P, Syngal S, Gruber SB
Gastroenterology. 2009
PubMed ID: 19622357
Risk of pancreatic cancer in families with Lynch syndrome.
Kastrinos F, Mukherjee B, Tayob N, Wang F, Sparr J, Raymond VM, Bandipalliam P, Stoffel EM, Gruber SB, Syngal S
JAMA. 2009
PubMed ID: 19861671
DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice.
Albertson TM, Ogawa M, Bugni JM, Hays LE, Chen Y, Wang Y, Treuting PM, Heddle JA, Goldsby RE, Preston BD
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19805137
Increased microsatellite instability and epigenetic inactivation of the hMLH1 gene in head and neck squamous cell carcinoma.
Zuo C, Zhang H, Spencer HJ, Vural E, Suen JY, Schichman SA, Smoller BR, Kokoska MS, Fan CY
Otolaryngol Head Neck Surg. 2009
PubMed ID: 19786217
Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members.
Järvinen HJ, Renkonen-Sinisalo L, Aktán-Collán K, Peltomäki P, Aaltonen LA, Mecklin JP
J Clin Oncol. 2009
PubMed ID: 19720893
A new mutation in Muir-Torre syndrome associated with familiar transmission of different gastrointestinal adenocarcinomas.
Tanyi M, Olasz J, Lukács G, Tanyi JL, Tóth L, Antal-Szalmás P, Ress Z, Bubán T, András C, Damjanovich L
Eur J Surg Oncol. 2009
PubMed ID: 19423266
Effect of DNA repair host factors on temozolomide or dacarbazine melanoma treatment in Caucasians.
Boeckmann L, Schirmer M, Rosenberger A, Struever D, Thoms KM, Gutzmer R, Has C, Kunz M, Kuschal C, Laspe P, Schoen MP, Brockmoeller J, Emmert S
Pharmacogenet Genomics. 2009
PubMed ID: 19741564
The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, Pita G, Milne R, Maravall J, Ramos I, Andía V, Rodríguez-Poyo P, Jara-Albarrán A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Picó A, Pomares F, Giménez G, López-Mondéjar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodríguez-Antona C, González-Neira A, Matías-Guiu X, Santisteban P, Robledo M
PLoS Genet. 2009
PubMed ID: 19730683
Germ-line mutations in mismatch repair genes associated with prostate cancer.
Grindedal EM, Møller P, Eeles R, Stormorken AT, Bowitz-Lothe IM, Landrø SM, Clark N, Kvåle R, Shanley S, Maehle L
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19723918
Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice.
Fu Z, Regan K, Zhang L, Muders MH, Thibodeau SN, French A, Wu Y, Kaufmann SH, Lingle WL, Chen J, Tindall DJ
J Clin Invest. 2009
PubMed ID: 19690386
A MLH1 polymorphism that increases cancer risk is associated with better outcome in sporadic colorectal cancer.
Nejda N, Iglesias D, Moreno Azcoita M, Medina Arana V, González-Aguilera JJ, Fernández-Peralta AM
Cancer Genet Cytogenet. 2009
PubMed ID: 19665066
MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells.
Imesch P, Dedes KJ, Furlato M, Fink D, Fedier A
Int J Oncol. 2009
PubMed ID: 19639184
Clinical implications of microsatellite instability and MLH1 gene inactivation in sporadic insulinomas.
Mei M, Deng D, Liu TH, Sang XT, Lu X, Xiang HD, Zhou J, Wu H, Yang Y, Chen J, Lu CM, Chen YJ
J Clin Endocrinol Metab. 2009
PubMed ID: 19567531
Cancer risk in a cohort of subjects carrying a single mismatch repair gene mutation.
Stupart DA, Goldberg PA, Algar U, Ramesar R
Fam Cancer. 2009
PubMed ID: 19688281
Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer.
Edwards RA, Witherspoon M, Wang K, Afrasiabi K, Pham T, Birnbaumer L, Lipkin SM
Cancer Res. 2009
PubMed ID: 19638594
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair.
Genschel J, Modrich P
J Biol Chem. 2009
PubMed ID: 19515846
[Clinicopathologic characteristics, diagnosis, and treatment of 30 patients with hereditary nonpolyposis colorectal cancer].
Liu H, Yan Z, Liao G, Yin H, Xie X
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009
PubMed ID: 19734583
Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.
Hussain SK, Mu LN, Cai L, Chang SC, Park SL, Oh SS, Wang Y, Goldstein BY, Ding BG, Jiang Q, Rao J, You NC, Yu SZ, Papp JC, Zhao JK, Wang H, Zhang ZF
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19661089
Stool methylation-specific polymerase chain reaction assay for the detection of colorectal neoplasia in Korean patients.
Baek YH, Chang E, Kim YJ, Kim BK, Sohn JH, Park DI
Dis Colon Rectum. 2009
PubMed ID: 19617759
Differences in expression between transcripts using alternative promoters of hMLH1 gene and their correlation with microsatellite instability.
Takahashi R, Nagai K
Oncol Rep. 2009
PubMed ID: 19578765
Intra-tumor heterogeneity of MLH1 promoter methylation revealed by deep single molecule bisulfite sequencing.
Varley KE, Mutch DG, Edmonston TB, Goodfellow PJ, Mitra RD
Nucleic Acids Res. 2009
PubMed ID: 19494183
Four novel germline mutations in the MLH1 and PMS2 mismatch repair genes in patients with hereditary nonpolyposis colorectal cancer.
Montazer Haghighi M, Radpour R, Aghajani K, Zali N, Molaei M, Zali MR
Int J Colorectal Dis. 2009
PubMed ID: 19479271
Expression of hMLH1 and hMSH2 proteins in pleomorphic adenoma of minor salivary glands: relationship with clinical and histologic findings.
Tobón-Arroyave SI, Flórez-Moreno GA, Jaramillo-Cárdenas JF, Arango-Uribe JD, Isaza-Guzmán DM, Rendón-Henao J, POPCAD Research Group
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009
PubMed ID: 19464205
Germline hypermethylation of MLH1 and EPCAM deletions are a frequent cause of Lynch syndrome.
Niessen RC, Hofstra RM, Westers H, Ligtenberg MJ, Kooi K, Jager PO, de Groote ML, Dijkhuizen T, Olderode-Berends MJ, Hollema H, Kleibeuker JH, Sijmons RH
Genes Chromosomes Cancer. 2009
PubMed ID: 19455606
Survival in women with MMR mutations and ovarian cancer; A multicentre study in Lynch Syndrome kindreds.
Grindedal EM, Renkonen-Sinisalo L, Vasen H, Evans G, Sala P, Blanco I, Gronwald J, Apold J, Eccles DM, Sánchez AA, Sampson J, Järvinen HJ, Bertario L, Crawford GC, Stormorken AT, Maehle L, Møller P
J Med Genet. 2009
PubMed ID: 19635727
Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.
Kweekel DM, Antonini NF, Nortier JW, Punt CJ, Gelderblom H, Guchelaar HJ
Br J Cancer. 2009
PubMed ID: 19536092
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats.
Eccleston J, Schrader CE, Yuan K, Stavnezer J, Selsing E
J Immunol. 2009
PubMed ID: 19553545
Loss of heterozygosity combined with promoter hypermethylation, the main mechanism of human MutL Homolog (hMLH1) gene inactivation in non-small cell lung cancer in a Chinese population.
Geng X, Wang F, Zhang L, Zhang WM
Tumori. 2009
PubMed ID: 19856662
Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age.
Shi Z, Johnstone D, Talseth-Palmer BA, Evans TJ, Spigelman AD, Groombridge C, Milward EA, Olynyk JK, Suchy J, Kurzawski G, Lubinski J, Scott RJ
Int J Cancer. 2009
PubMed ID: 19291797
MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events.
de Vogel S, Weijenberg MP, Herman JG, Wouters KA, de Goeij AF, van den Brandt PA, de Bruïne AP, van Engeland M
Ann Oncol. 2009
PubMed ID: 19164452
Screening for germline mutations of MLH1, MSH2, MSH6 and PMS2 genes in Slovenian colorectal cancer patients: implications for a population specific detection strategy of Lynch syndrome.
Berginc G, Bračko M, Ravnik-Glavač M, Glavač D
Fam Cancer. 2009
PubMed ID: 19526325
Polymorphisms of MLH1 in benign prostatic hyperplasia and sporadic prostate cancer.
Tanaka Y, Zaman MS, Majid S, Liu J, Kawakami K, Shiina H, Tokizane T, Dahiya AV, Sen S, Nakajima K
Biochem Biophys Res Commun. 2009
PubMed ID: 19364498
[Association of MLH1 gene 415G/C polymorphism with colorectal cancer in Chinese]
Tao WP, Hu S, Feng JP, Xie YS
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009
PubMed ID: 19504447
Efficient molecular screening of Lynch syndrome by specific 3' promoter methylation of the MLH1 or BRAF mutation in colorectal cancer with high-frequency microsatellite instability.
Nakagawa H, Nagasaka T, Cullings HM, Notohara K, Hoshijima N, Young J, Lynch HT, Tanaka N, Matsubara N
Oncol Rep. 2009
PubMed ID: 19424639
Distribution of MLH1 foci and inter-focal distances in spermatocytes of infertile men.
Ferguson KA, Leung S, Jiang D, Ma S
Hum Reprod. 2009
PubMed ID: 19246465
A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair.
Kadyrov FA, Genschel J, Fang Y, Penland E, Edelmann W, Modrich P
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19420220
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Analysis of microsatellite instability, protein expression and methylation status of hMLH1 and hMSH2 genes in gastric carcinomas.
Gu M, Kim D, Bae Y, Choi J, Kim S, Song S
Hepatogastroenterology. 2009
PubMed ID: 19621725
Effectiveness of each Bethesda marker in defining microsatellite instability when screening for Lynch syndrome.
Sinn DH, Chang DK, Kim YH, Rhee PL, Kim JJ, Kim DS, Park CK, Kim JW, Yun SH, Lee WY, Chun HK, Rhee JC
Hepatogastroenterology. 2009
PubMed ID: 19621678
MutL-homolog 1 expression and risk of incident, sporadic colorectal adenoma: search for prospective biomarkers of risk for colorectal cancer.
Sidelnikov E, Bostick RM, Flanders WD, Long Q, Cohen VL, Dash C, Seabrook ME, Fedirko V
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19423536
A novel germline mutation of hMLH1 in a Korean hereditary non-polyposis colorectal cancer family.
Kim KH, Kim JY, Oh SI, Baik HW, Kang DW, Jung SH, Rho JH, Hwang IT
Int J Oncol. 2009
PubMed ID: 19360343
Classifying MLH1 and MSH2 variants using bioinformatic prediction, splicing assays, segregation, and tumor characteristics.
Arnold S, Buchanan DD, Barker M, Jaskowski L, Walsh MD, Birney G, Woods MO, Hopper JL, Jenkins MA, Brown MA, Tavtigian SV, Goldgar DE, Young JP, Spurdle AB
Hum Mutat. 2009
PubMed ID: 19267393
Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.
Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Méjean A, Desgrandchamps F, Lathrop M, Sarasin A, Benhamou S
Carcinogenesis. 2009
PubMed ID: 19237606
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
Genetic mutations associated with cigarette smoking in pancreatic cancer.
Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH
Cancer Res. 2009
PubMed ID: 19351817
Common germline variation in mismatch repair genes and survival after a diagnosis of colorectal cancer.
Koessler T, Azzato EM, Perkins B, Macinnis RJ, Greenberg D, Easton DF, Pharoah PD
Int J Cancer. 2009
PubMed ID: 19115210
Germ line MLH1 and MSH2 mutations in Taiwanese Lynch syndrome families: characterization of a founder genomic mutation in the MLH1 gene.
Tang R, Hsiung C, Wang JY, Lai CH, Chien HT, Chiu LL, Liu CT, Chen HH, Wang HM, Chen SX, Hsieh LL, TCOG HNPCC Consortium
Clin Genet. 2009
PubMed ID: 19419416
Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management.
Lynch HT, Casey MJ, Snyder CL, Bewtra C, Lynch JF, Butts M, Godwin AK
Mol Oncol. 2009
PubMed ID: 19383374
I219V polymorphism in hMLH1 gene in patients affected with ulcerative colitis.
Vietri MT, Riegler G, De Paola M, Simeone S, Boggia M, Improta A, Parisi M, Molinari AM, Cioffi M
Genet Test Mol Biomarkers. 2009
PubMed ID: 19371218
Promoter hypermethylation of mismatch repair genes, hMLH1 and hMSH2 in oral squamous cell carcinoma.
Czerninski R, Krichevsky S, Ashhab Y, Gazit D, Patel V, Ben-Yehuda D
Oral Dis. 2009
PubMed ID: 19207881
PMS2 involvement in patients suspected of Lynch syndrome.
Niessen RC, Kleibeuker JH, Westers H, Jager PO, Rozeveld D, Bos KK, Boersma-van Ek W, Hollema H, Sijmons RH, Hofstra RM
Genes Chromosomes Cancer. 2009
PubMed ID: 19132747
Oviduct-specific glycoprotein is a molecular marker for invasion in endometrial tumorigenesis identified using a relevant mouse model.
Wang H, Joshi A, Iaconis L, Solomon GJ, Xiang Z, Verhage HG, Douglas W, Ronnett BM, Ellenson LH
Int J Cancer. 2009
PubMed ID: 19101990
Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo.
Steele N, Finn P, Brown R, Plumb JA
Br J Cancer. 2009
PubMed ID: 19259094
Prediction of Lynch syndrome in consecutive patients with colorectal cancer.
Green RC, Parfrey PS, Woods MO, Younghusband HB
J Natl Cancer Inst. 2009
PubMed ID: 19244167
Introduction of cytogenetic tests in colorectal cancer screening.
Suceveanu AI, Suceveanu A, Voinea F, Mazilu L, Mixici F, Adam T
J Gastrointestin Liver Dis. 2009
PubMed ID: 19337631
Differentiating the undifferentiated: immunohistochemical profile of medullary carcinoma of the colon with an emphasis on intestinal differentiation.
Winn B, Tavares R, Fanion J, Noble L, Gao J, Sabo E, Resnick MB
Hum Pathol. 2009
PubMed ID: 18992917
Genetic diagnosis strategy of hereditary non-polyposis colorectal cancer.
Sheng JQ, Zhang H, Ji M, Fu L, Mu H, Zhang MZ, Huang JS, Han M, Li AQ, Wei Z, Sun ZQ, Wu ZT, Xia CH, Li SR
World J Gastroenterol. 2009
PubMed ID: 19248199
Perforin-mediated suppression of B-cell lymphoma.
Bolitho P, Street SE, Westwood JA, Edelmann W, Macgregor D, Waring P, Murray WK, Godfrey DI, Trapani JA, Johnstone RW, Smyth MJ
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19196996
Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel.
Vilkin A, Niv Y, Nagasaka T, Morgenstern S, Levi Z, Fireman Z, Fuerst F, Goel A, Boland CR
Cancer. 2009
PubMed ID: 19127559
Normal colorectal mucosa exhibits sex- and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters.
Menigatti M, Truninger K, Gebbers JO, Marbet U, Marra G, Schär P
Oncogene. 2009
PubMed ID: 19060925
Cumulative lifetime incidence of extracolonic cancers in Lynch syndrome: a report of 121 families with proven mutations.
Barrow E, Robinson L, Alduaij W, Shenton A, Clancy T, Lalloo F, Hill J, Evans DG
Clin Genet. 2009
PubMed ID: 19215248
Surveillance colonoscopy improves survival in a cohort of subjects with a single mismatch repair gene mutation.
Stupart DA, Goldberg PA, Algar U, Ramesar R
Colorectal Dis. 2009
PubMed ID: 19143775
Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair.
Dherin C, Gueneau E, Francin M, Nunez M, Miron S, Liberti SE, Rasmussen LJ, Zinn-Justin S, Gilquin B, Charbonnier JB, Boiteux S
Mol Cell Biol. 2009
PubMed ID: 19015241
Deficient mismatch repair system in patients with sporadic advanced colorectal cancer.
Koopman M, Kortman GA, Mekenkamp L, Ligtenberg MJ, Hoogerbrugge N, Antonini NF, Punt CJ, van Krieken JH
Br J Cancer. 2009
PubMed ID: 19165197
The G67E mutation in hMLH1 is associated with an unusual presentation of Lynch syndrome.
Clyne M, Offman J, Shanley S, Virgo JD, Radulovic M, Wang Y, Ardern-Jones A, Eeles R, Hoffmann E, Yu VP
Br J Cancer. 2009
PubMed ID: 19142183
Role for genetic anticipation in Lynch syndrome.
Nilbert M, Timshel S, Bernstein I, Larsen K
J Clin Oncol. 2009
PubMed ID: 19075283
Three new nonsense mutations of MLH1 and MSH2 genes in Korean families with hereditary nonpolyposis colorectal cancer.
Yoon S, Park TS, Kim NK, Lee KA, Kim J, Song J, Kim BY, Choi JR
Cancer Genet Cytogenet. 2009
PubMed ID: 19100506
Cancer risk in MLH1, MSH2 and MSH6 mutation carriers; different risk profiles may influence clinical management.
Ramsoekh D, Wagner A, van Leerdam ME, Dooijes D, Tops CM, Steyerberg EW, Kuipers EJ
Hered Cancer Clin Pract. 2009
PubMed ID: 20028567
Three synchronous primary carcinomas in a patient with HNPCC associated with a novel germline mutation in MLH1: Case report.
Valenzuela CD, Moore HG, Huang WC, Reich EW, Yee H, Ostrer H, Pachter HL
World J Surg Oncol. 2009
PubMed ID: 19995443
Partial loss of heterozygosity events at the mutated gene in tumors from MLH1/MSH2 large genomic rearrangement carriers.
Zavodna K, Krivulcik T, Bujalkova MG, Slamka T, Martinicky D, Ilencikova D, Bartosova Z
BMC Cancer. 2009
PubMed ID: 19930554
Analysis of candidate genes in occurrence and growth of colorectal adenomas.
Olschwang S, Vernerey D, Cottet V, Pariente A, Nalet B, Lafon J, Faivre J, Laurent-Puig P, Bonithon-Kopp C, Bonaiti-Pellié C
J Oncol. 2009
PubMed ID: 19888426
Assessing pathogenicity of MLH1 variants by co-expression of human MLH1 and PMS2 genes in yeast.
Vogelsang M, Comino A, Zupanec N, Hudler P, Komel R
BMC Cancer. 2009
PubMed ID: 19863800
A study on MSH2 and MLH1 mutations in hereditary nonpolyposis colorectal cancer families from the Basque Country, describing four new germline mutations.
Martínez-Bouzas C, Beristain E, Ojembarrena E, Errasti J, Mujika K, Viguera N, Tejada MI
Fam Cancer. 2009
PubMed ID: 19760518
Germline MLH1 and MSH2 mutations in Italian pancreatic cancer patients with suspected Lynch syndrome.
Gargiulo S, Torrini M, Ollila S, Nasti S, Pastorino L, Cusano R, Bonelli L, Battistuzzi L, Mastracci L, Bruno W, Savarino V, Sciallero S, Borgonovo G, Nyström M, Bianchi-Scarrà G, Mareni C, Ghiorzo P
Fam Cancer. 2009
PubMed ID: 19728162
Aberrant DNA hypermethylation of hMLH-1 and CDKN2A/p16 genes in benign, premalignant and malignant endometrial lesions.
Guida M, Sanguedolce F, Bufo P, Di Spiezio Sardo A, Bifulco G, Nappi C, Pannone G
Eur J Gynaecol Oncol. 2009
PubMed ID: 19697618
Functional characterization of rare missense mutations in MLH1 and MSH2 identified in Danish colorectal cancer patients.
Christensen LL, Kariola R, Korhonen MK, Wikman FP, Sunde L, Gerdes AM, Okkels H, Brandt CA, Bernstein I, Hansen TV, Hagemann-Madsen R, Andersen CL, Nyström M, Ørntoft TF
Fam Cancer. 2009
PubMed ID: 19697156
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Determination of splice-site mutations in Lynch syndrome (hereditary non-polyposis colorectal cancer) patients using functional splicing assay.
Naruse H, Ikawa N, Yamaguchi K, Nakamura Y, Arai M, Ishioka C, Sugano K, Tamura K, Tomita N, Matsubara N, Yoshida T, Moriya Y, Furukawa Y
Fam Cancer. 2009
PubMed ID: 19685281
Epitope-positive truncating MLH1 mutation and loss of PMS2: implications for IHC-directed genetic testing for Lynch syndrome.
Zighelboim I, Powell MA, Babb SA, Whelan AJ, Schmidt AP, Clendenning M, Senter L, Thibodeau SN, de la Chapelle A, Goodfellow PJ
Fam Cancer. 2009
PubMed ID: 19672700
Clinical significance of epigenetic inactivation of hMLH1 and BRCA1 in Tunisian patients with invasive breast carcinoma.
Karray-Chouayekh S, Trifa F, Khabir A, Boujelbane N, Sellami-Boudawara T, Daoud J, Frikha M, Gargouri A, Mokdad-Gargouri R
J Biomed Biotechnol. 2009
PubMed ID: 19644562
In vitro nuclear interactome of the HIV-1 Tat protein.
Gautier VW, Gu L, O'Donoghue N, Pennington S, Sheehy N, Hall WW
Retrovirology. 2009
PubMed ID: 19454010
The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies.
Bansal N, Yendluri V, Wenham RM
Cancer Control. 2009
PubMed ID: 19078924
An empirical framework for binary interactome mapping.
Venkatesan K, Rual JF, Vazquez A, Stelzl U, Lemmens I, Hirozane-Kishikawa T, Hao T, Zenkner M, Xin X, Goh KI, Yildirim MA, Simonis N, Heinzmann K, Gebreab F, Sahalie JM, Cevik S, Simon C, de Smet AS, Dann E, Smolyar A, Vinayagam A, Yu H, Szeto D, Borick H, Dricot A, Klitgord N, Murray RR, Lin C, Lalowski M, Timm J, Rau K, Boone C, Braun P, Cusick ME, Roth FP, Hill DE, Tavernier J, Wanker EE, Barabási AL, Vidal M
Nat Methods. 2009
PubMed ID: 19060904
Major contribution from recurrent alterations and MSH6 mutations in the Danish Lynch syndrome population.
Nilbert M, Wikman FP, Hansen TV, Krarup HB, Orntoft TF, Nielsen FC, Sunde L, Gerdes AM, Cruger D, Timshel S, Bisgaard ML, Bernstein I, Okkels H
Fam Cancer. 2009
PubMed ID: 18566915
MLH1 promoter germline-methylation in selected probands of Chinese hereditary non-polyposis colorectal cancer families.
Zhou HH, Yan SY, Zhou XY, Du X, Zhang TM, Cai X, Lu YM, Cai SJ, Shi DR
World J Gastroenterol. 2008
PubMed ID: 19109866
Analysis of hMLH1 and hMSH2 expression in cisplatin-treated ovarian cancer patients.
Magnowska M, Surowiak P, Nowak-Markwitz E, Michalak M, Magnowski P, Rokita W, Kedzia H, Zabel M, Spaczyński M
Ginekol Pol. 2008
PubMed ID: 19175039
[Effects of 5-Aza-2'-deoxycytidine and trichostatin A on DNA methylation and expression of hMLH1 in ovarian cancer cell line COC1/DDP]
Meng CF, Dai DQ, Guo KJ
Ai Zheng. 2008
PubMed ID: 19079988
Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064572
Case-only study of interactions between DNA repair genes (hMLH1, APEX1, MGMT, XRCC1 and XPD) and low-frequency electromagnetic fields in childhood acute leukemia.
Yang Y, Jin X, Yan C, Tian Y, Tang J, Shen X
Leuk Lymphoma. 2008
PubMed ID: 19052983
Two new MLH1 germline mutations in Brazilian Lynch syndrome families.
Dominguez MV, Bastos EP, Santos EM, Oliveira LP, Ferreira FO, Carraro DM, Rossi BM
Int J Colorectal Dis. 2008
PubMed ID: 18594839
A large fraction of unclassified variants of the mismatch repair genes MLH1 and MSH2 is associated with splicing defects.
Tournier I, Vezain M, Martins A, Charbonnier F, Baert-Desurmont S, Olschwang S, Wang Q, Buisine MP, Soret J, Tazi J, Frébourg T, Tosi M
Hum Mutat. 2008
PubMed ID: 18561205
Difficulties in recognizing families with Hereditary Non-polyposis Colorectal Carcinoma. Presentation of 4 families with proven mutation.
Tanyi M, Olasz J, Kámory E, Csuka O, Tanyi JL, Ress Z, Damjanovich L
Eur J Surg Oncol. 2008
PubMed ID: 18289827
Helicobacter pylori infection and expression of DNA mismatch repair proteins.
Mirzaee V, Molaei M, Shalmani HM, Zali MR
World J Gastroenterol. 2008
PubMed ID: 19034977
Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines.
Vilar E, Scaltriti M, Balmaña J, Saura C, Guzman M, Arribas J, Baselga J, Tabernero J
Br J Cancer. 2008
PubMed ID: 18941461
MLH1 -93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer.
Allan JM, Shorto J, Adlard J, Bury J, Coggins R, George R, Katory M, Quirke P, Richman S, Scott D, Scott K, Seymour M, Travis LB, Worrillow LJ, Bishop DT, Cox A, UK NCRI Colorectal Clinical Studies Group, Colorectal Cancer Study Group
Int J Cancer. 2008
PubMed ID: 18712731
Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening.
Poynter JN, Siegmund KD, Weisenberger DJ, Long TI, Thibodeau SN, Lindor N, Young J, Jenkins MA, Hopper JL, Baron JA, Buchanan D, Casey G, Levine AJ, Le Marchand L, Gallinger S, Bapat B, Potter JD, Newcomb PA, Haile RW, Laird PW, Colon Cancer Family Registry Investigators
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18990764
Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer.
Bendardaf R, Lamlum H, Ristamäki R, Syrjänen K, Pyrhönen S
Oncol Rep. 2008
PubMed ID: 18949393
Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1.
He W, Zhao Y, Zhang C, An L, Hu Z, Liu Y, Han L, Bi L, Xie Z, Xue P, Yang F, Hang H
Nucleic Acids Res. 2008
PubMed ID: 18842633
Multiplex SNaPshot genotyping for detecting loss of heterozygosity in the mismatch-repair genes MLH1 and MSH2 in microsatellite-unstable tumors.
Bujalkova M, Zavodna K, Krivulcik T, Ilencikova D, Wolf B, Kovac M, Karner-Hanusch J, Heinimann K, Marra G, Jiricny J, Bartosova Z
Clin Chem. 2008
PubMed ID: 18772310
Exclusive KRAS mutation in microsatellite-unstable human colorectal carcinomas with sequence alterations in the DNA mismatch repair gene, MLH1.
Zhao Y, Miyashita K, Ando T, Kakeji Y, Yamanaka T, Taguchi K, Ushijima T, Oda S, Maehara Y
Gene. 2008
PubMed ID: 18692554
High risk of endometrial cancer in colorectal cancer kindred is pathognomonic for MMR-mutation carriers.
Grindedal EM, Blanco I, Stormorken A, Maehle L, Clark N, González S, Capella G, Vasen H, Burn J, Møller P
Fam Cancer. 2008
PubMed ID: 18841495
Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma.
Wang SS, Maurer MJ, Morton LM, Habermann TM, Davis S, Cozen W, Lynch CF, Severson RK, Rothman N, Chanock SJ, Hartge P, Cerhan JR
Leukemia. 2008
PubMed ID: 18830263
Expression and promoter methylation status of mismatch repair gene hMLH1 and hMSH2 in epithelial ovarian cancer.
Zhang H, Zhang S, Cui J, Zhang A, Shen L, Yu H
Aust N Z J Obstet Gynaecol. 2008
PubMed ID: 19032668
Frequent alterations of hMLH1 and RBSP3/HYA22 at chromosomal 3p22.3 region in early and late-onset breast carcinoma: clinical and prognostic significance.
Sinha S, Singh RK, Alam N, Roy A, Roychoudhury S, Panda CK
Cancer Sci. 2008
PubMed ID: 19016758
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
Expression of mismatch repair proteins, hMLH1/hMSH2, in non-small cell lung cancer tissues and its clinical significance.
Kouso H, Yoshino I, Miura N, Takenaka T, Ohba T, Yohena T, Osoegawa A, Shoji F, Maehara Y
J Surg Oncol. 2008
PubMed ID: 18646042
Redundant DNA methylation in colorectal cancers of Lynch-syndrome patients.
Alemayehu A, Sebova K, Fridrichova I
Genes Chromosomes Cancer. 2008
PubMed ID: 18618713
The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer.
Samowitz WS, Curtin K, Wolff RK, Albertsen H, Sweeney C, Caan BJ, Ulrich CM, Potter JD, Slattery ML
Genes Chromosomes Cancer. 2008
PubMed ID: 18615680
Immunoexpression of hMSH2 and hMLH1 in oral squamous cell carcinoma and its relationship to histological grades of malignancy.
Fernandes AM, Ramos-Jorge ML, Cardoso SV, Loyola AM, Mesquita RA, Aguiar MC
J Oral Pathol Med. 2008
PubMed ID: 18331286
Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects.
Ashktorab H, Brim H, Al-Riyami M, Date A, Al-Mawaly K, Kashoub M, Al-Mjeni R, Smoot DT, Al-Moundhri M, Al-Hashemi S, Ganguly SS, Raeburn S
Dig Dis Sci. 2008
PubMed ID: 18299982
Do polymorphisms and haplotypes of mismatch repair genes modulate risk of sporadic colorectal cancer?
Tulupova E, Kumar R, Hanova M, Slyskova J, Pardini B, Polakova V, Naccarati A, Vodickova L, Novotny J, Halamkova J, Hemminki K, Vodicka P
Mutat Res. 2008
PubMed ID: 18851982
IGF1 is a modifier of disease risk in hereditary non-polyposis colorectal cancer.
Reeves SG, Rich D, Meldrum CJ, Colyvas K, Kurzawski G, Suchy J, Lubinski J, Scott RJ
Int J Cancer. 2008
PubMed ID: 18623088
Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer.
de Vogel S, Bongaerts BW, Wouters KA, Kester AD, Schouten LJ, de Goeij AF, de Bruïne AP, Goldbohm RA, van den Brandt PA, van Engeland M, Weijenberg MP
Carcinogenesis. 2008
PubMed ID: 18339680
Identification in Daily Practice of Patients With Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer): Revised Bethesda Guidelines-Based Approach Versus Molecular Screening.
Julié C, Trésallet C, Brouquet A, Vallot C, Zimmermann U, Mitry E, Radvanyi F, Rouleau E, Lidereau R, Coulet F, Olschwang S, Frébourg T, Rougier P, Nordlinger B, Laurent-Puig P, Penna C, Boileau C, Franc B, Muti C, Hofmann-Radvanyi H
Am J Gastroenterol. 2008
PubMed ID: 18759827
Recurring MLH1 deleterious mutations in unrelated Chinese Lynch syndrome families in Singapore.
Yap HL, Chieng WS, Lim JR, Lim RS, Soo R, Guo J, Lee SC
Fam Cancer. 2008
PubMed ID: 18726168
Mismatch repair gene polymorphisms and survival in invasive ovarian cancer patients.
Mann A, Hogdall E, Ramus SJ, Dicioccio RA, Hogdall C, Quaye L, McGuire V, Whittemore AS, Shah M, Greenberg D, Easton DF, Ponder BA, Kjaer SK, Gayther SA, Thompson DJ, Pharoah PD, Song H
Eur J Cancer. 2008
PubMed ID: 18723338
Polygenic Model of DNA-Repair Genetic Polymorphisms in Human Breast Cancer Risk.
Smith TR, Levine EA, Freimanis RI, Akman SA, Allen GO, Hoang KN, Liu-Mares W, Hu JJ
Carcinogenesis. 2008
PubMed ID: 18701435
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Phenotype comparison of MLH1 and MSH2 mutation carriers in a cohort of 1,914 individuals undergoing clinical genetic testing in the United States.
Kastrinos F, Stoffel EM, Balmaña J, Steyerberg EW, Mercado R, Syngal S
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18708397
[Association of genetic polymorphisms and haplotypes in hMLH1 and hMSH3 gene with the risk of papillary thyroid carcinoma.]
Shi W, Bian J, Jiang F, Ni H, Zhu Q, Tang H, Shen Q, Wu Y
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008
PubMed ID: 18683134
DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediated apoptosis.
Li LS, Morales JC, Hwang A, Wagner MW, Boothman DA
J Biol Chem. 2008
PubMed ID: 18480060
[Mutation of hMLH1 and hMSH2 genes in hereditary nonpolyposis colorectal cancer: analysis of 76 probands]
Fu L, Sheng JQ, Sun ZQ, Han M, Huang JS, Mu H, Han WL, Niu HL, Li AQ, Wu ZT, Li SR
Zhonghua Yi Xue Za Zhi. 2008
PubMed ID: 19062740
DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma.
Seng TJ, Currey N, Cooper WA, Lee CS, Chan C, Horvath L, Sutherland RL, Kennedy C, McCaughan B, Kohonen-Corish MR
Br J Cancer. 2008
PubMed ID: 18594535
Clinical features and hMSH2/hMLH1 germ-line mutations in Chinese patients with hereditary nonpolyposis colorectal cancer.
Shen XS, Zhao B, Wang ZJ
Chin Med J (Engl). 2008
PubMed ID: 18713544
DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study.
Capellá G, Pera G, Sala N, Agudo A, Rico F, Del Giudicce G, Plebani M, Palli D, Boeing H, Bueno-de-Mesquita HB, Carneiro F, Berrino F, Vineis P, Tumino R, Panico S, Berglund G, Simán H, Nyrén O, Hallmans G, Martinez C, Dorronsoro M, Barricarte A, Navarro C, Quirós JR, Allen N, Key T, Bingham S, Caldas C, Linseisen J, Nagel G, Overvad K, Tjonneland A, Boshuizen HC, Peeters PH, Numans ME, Clavel-Chapelon F, Trichopoulou A, Lund E, Jenab M, Kaaks R, Riboli E, González CA
Int J Epidemiol. 2008
PubMed ID: 18641418
Cell lineage analysis of a mouse tumor.
Frumkin D, Wasserstrom A, Itzkovitz S, Stern T, Harmelin A, Eilam R, Rechavi G, Shapiro E
Cancer Res. 2008
PubMed ID: 18632647
Hypermethylation of the DNA mismatch repair gene hMLH1 and its association with lymph node metastasis and T1799A BRAF mutation in patients with papillary thyroid cancer.
Guan H, Ji M, Hou P, Liu Z, Wang C, Shan Z, Teng W, Xing M
Cancer. 2008
PubMed ID: 18470905
Influence of DNA repair gene polymorphisms on the initial repair of MMS-induced DNA damage in human lymphocytes as measured by the alkaline comet assay.
Ryk C, Routledge MN, Allan JM, Wild CP, Kumar R, Lambert B, Hou S
Environ Mol Mutagen. 2008
PubMed ID: 18627000
Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2.
Nakamura H, Tanimoto K, Hiyama K, Yunokawa M, Kawamoto T, Kato Y, Yoshiga K, Poellinger L, Hiyama E, Nishiyama M
Oncogene. 2008
PubMed ID: 18345027
Genotype-phenotype relationship between DNA repair gene genetic polymorphisms and DNA repair capacity.
Shin A, Lee KM, Ahn B, Park CG, Noh SK, Park DY, Ahn SH, Yoo KY, Kang D
Asian Pac J Cancer Prev. 2008
PubMed ID: 18990028
Reduced mRNA expression in paraffin-embedded tissue identifies MLH1- and MSH2-deficient colorectal tumours and potential mutation carriers.
Müller A, Zielinski D, Friedrichs N, Oberschmid B, Merkelbach-Bruse S, Schackert HK, Linnebacher M, von Knebel Doeberitz M, Büttner R, Rüschoff J, German HNPCC Consortium, German Cancer Aid Deutsche Krebshilfe
Virchows Arch. 2008
PubMed ID: 18581137
Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC.
Morak M, Schackert HK, Rahner N, Betz B, Ebert M, Walldorf C, Royer-Pokora B, Schulmann K, von Knebel-Doeberitz M, Dietmaier W, Keller G, Kerker B, Leitner G, Holinski-Feder E
Eur J Hum Genet. 2008
PubMed ID: 18301449
Molecular epidemiological and mutational analysis of DNA mismatch repair (MMR) genes in endometrial cancer patients with HNPCC-associated familial predisposition to cancer.
Hirai Y, Banno K, Suzuki M, Ichikawa Y, Udagawa Y, Sugano K, Miki Y
Cancer Sci. 2008
PubMed ID: 18624996
Epigenetic signatures of familial cancer are characteristic of tumor type and family category.
Joensuu EI, Abdel-Rahman WM, Ollikainen M, Ruosaari S, Knuutila S, Peltomäki P
Cancer Res. 2008
PubMed ID: 18559504
Colorectal cancer in HNPCC: cumulative lifetime incidence, survival and tumour distribution. A report of 121 families with proven mutations.
Barrow E, Alduaij W, Robinson L, Shenton A, Clancy T, Lalloo F, Hill J, Evans D
Clin Genet. 2008
PubMed ID: 18554281
Mismatch repair polymorphisms and risk of colon cancer, tumor microsatellite instability, and interactions with lifestyle factors.
Campbell PT, Curtin K, Ulrich C, Samowitz W, Bigler J, Velicer C, Caan B, Potter J, Slattery M
Gut. 2008
PubMed ID: 18523027
Role of DNA repair systems in malignant tumor development in the elderly.
Arai T, Sawabe M, Hosoi T, Tanaka N
Geriatr Gerontol Int. 2008
PubMed ID: 18713157
[Comparison of clinical and genetic phenotypes between Chinese and Korean hereditary nonpolyposis colorectal cancer families]
Shen H, Yuan Y, Song YM, Huang YQ, Zheng S
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008
PubMed ID: 18543228
Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer.
Ide T, Kitajima Y, Ohtaka K, Mitsuno M, Nakafusa Y, Miyazaki K
Oncol Rep. 2008
PubMed ID: 18497967
Ovarian cancer risk is associated with a common variant in the promoter sequence of the mismatch repair gene MLH1.
Harley I, Rosen B, Risch HA, Siminovitch K, Beiner ME, McLaughlin J, Sun P, Narod SA
Gynecol Oncol. 2008
PubMed ID: 18405947
The interplay between hMLH1 and hMRE11: role in MMR and the effect of hMLH1 mutations.
Zhao N, Zhu F, Yuan F, Haick AK, Fukushige S, Gu L, Her C
Biochem Biophys Res Commun. 2008
PubMed ID: 18373977
Higher occurrence of childhood cancer in families with germline mutations in BRCA2, MMR and CDKN2A genes.
Magnusson S, Borg A, Kristoffersson U, Nilbert M, Wiebe T, Olsson H
Fam Cancer. 2008
PubMed ID: 18481196
Evaluation of the MLH1 I219V alteration in DNA mismatch repair activity and ulcerative colitis.
Plotz G, Raedle J, Spina A, Welsch C, Stallmach A, Zeuzem S, Schmidt C
Inflamm Bowel Dis. 2008
PubMed ID: 18200512
[Mutation screening of MLH1 and MSH2 genes in two Chinese families with hereditary nonpolyposis colorectal cancer]
Xie ZG, Hu ZM, Gong HY
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008
PubMed ID: 18393252
Clinicopathologic and molecular features of sporadic microsatellite- and chromosomal-stable colorectal cancers.
Cai G, Xu Y, Lu H, Shi Y, Lian P, Peng J, Du X, Zhou X, Guan Z, Shi D, Cai S
Int J Colorectal Dis. 2008
PubMed ID: 18193434
Common variants in mismatch repair genes and risk of colorectal cancer.
Koessler T, Oestergaard MZ, Song H, Tyrer J, Perkins B, Dunning A, Easton D, Pharoah PP
Gut. 2008
PubMed ID: 18364438
Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis.
Avdievich E, Reiss C, Scherer SJ, Zhang Y, Maier SM, Jin B, Hou H, Rosenwald A, Riedmiller H, Kucherlapati R, Cohen PE, Edelmann W, Kneitz B
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18337503
Implications of mismatch repair genes hMLH1 and hMSH2 in patients with sporadic renal cell carcinoma.
Rubio-Del-Campo A, Salinas-Sánchez AS, Sánchez-Sánchez F, Giménez-Bachs JM, Donate-Moreno MJ, Pastor-Navarro H, Carrión-López P, Escribano J
BJU Int. 2008
PubMed ID: 18325052
Meiotic failure in male mice lacking an X-linked factor.
Yang F, Gell K, van der Heijden GW, Eckardt S, Leu NA, Page DC, Benavente R, Her C, Höög C, McLaughlin KJ, Wang PJ
Genes Dev. 2008
PubMed ID: 18316482
Poorly differentiated colorectal adenocarcinomas show higher rates of microsatellite instability and promoter methylation of p16 and hMLH1: a study matched for T classification and tumor location.
Kazama Y, Watanabe T, Kanazawa T, Tanaka J, Tanaka T, Nagawa H
J Surg Oncol. 2008
PubMed ID: 18161865
Comparative analysis of meiotic progression in female mice bearing mutations in genes of the DNA mismatch repair pathway.
Kan R, Sun X, Kolas NK, Avdievich E, Kneitz B, Edelmann W, Cohen PE
Biol Reprod. 2008
PubMed ID: 18057311
Classification of ambiguous mutations in DNA mismatch repair genes identified in a population-based study of colorectal cancer.
Barnetson RA, Cartwright N, van Vliet A, Haq N, Drew K, Farrington S, Williams N, Warner J, Campbell H, Porteous ME, Dunlop MG
Hum Mutat. 2008
PubMed ID: 18033691
Polymorphic MLH1 and risk of cancer after methylating chemotherapy for Hodgkin lymphoma.
Worrillow LJ, Smith AG, Scott K, Andersson M, Ashcroft AJ, Dores GM, Glimelius B, Holowaty E, Jackson GH, Jones GL, Lynch CF, Morgan G, Pukkala E, Scott D, Storm HH, Taylor PR, Vyberg M, Willett E, Travis LB, Allan JM
J Med Genet. 2008
PubMed ID: 17959715
Comprehensive analysis of DNA repair gene variants and risk of meningioma.
Bethke L, Murray A, Webb E, Schoemaker M, Muir K, McKinney P, Hepworth S, Dimitropoulou P, Lophatananon A, Feychting M, Lönn S, Ahlbom A, Malmer B, Henriksson R, Auvinen A, Kiuru A, Salminen T, Johansen C, Christensen HC, Kosteljanetz M, Swerdlow A, Houlston R
J Natl Cancer Inst. 2008
PubMed ID: 18270339
Low hMLH1 expression prior to definitive chemoradiotherapy predicts poor prognosis in esophageal squamous cell carcinoma.
Nam TK, Lee JH, Cho SH, Chung IJ, Ahn SJ, Song JY, Yoon MS, Chung WK, Nah BS
Cancer Lett. 2008
PubMed ID: 18053639
Evidence that a mutation in the MLH1 3'-untranslated region confers a mutator phenotype and mismatch repair deficiency in patients with relapsed leukemia.
Mao G, Pan X, Gu L
J Biol Chem. 2008
PubMed ID: 18056700
Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats.
Nishimura J, Dewa Y, Okamura T, Muguruma M, Jin M, Saegusa Y, Umemura T, Mitsumori K
Arch Toxicol. 2008
PubMed ID: 18253720
[Influence of mifepristone on DNA repair genes and cisplatin sensitivity in human ovarian cancer drug-resistance cells].
Liu GY, Qu QX, Mi RR, Qi J
Zhonghua Fu Chan Ke Za Zhi. 2008
PubMed ID: 18683754
The MLH1 variants p.Arg265Cys and p.Lys618Ala affect protein stability while p.Leu749Gln affects heterodimer formation.
Perera S, Bapat B
Hum Mutat. 2008
PubMed ID: 18205192
Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae.
Li M, Liu L, Wang Z, Wang L, Liu Z, Xu G, Lu S
Oncol Rep. 2008
PubMed ID: 18202787
Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population.
An Y, Jin G, Wang H, Wang Y, Liu H, Li R, Wang H, Qian J, Sun W, Wang Y, Ma H, Miao R, Hu Z, Jin L, Wei Q, Shen H, Huang W, Lu D
Lung Cancer. 2008
PubMed ID: 17870204
Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha.
Sacho EJ, Kadyrov FA, Modrich P, Kunkel TA, Erie DA
Mol Cell. 2008
PubMed ID: 18206974
Association between folate metabolism-related gene polymorphisms and methylation of p16(INK4A) and hMLH1 genes in spontaneously aborted embryos with normal chromosomal integrity.
Park HM, Shin SJ, Choi DH, Oh D, Lee S, Kim NK
Fertil Steril. 2008
PubMed ID: 18177869
Risk of gynecologic cancers in Danish hereditary non-polyposis colorectal cancer families.
Boilesen AE, Bisgaard ML, Bernstein I
Acta Obstet Gynecol Scand. 2008
PubMed ID: 18972272
Mismatch repair gene mutations in Chinese HNPCC patients.
Sheng JQ, Fu L, Sun ZQ, Huang JS, Han M, Mu H, Zhang H, Zhang YZ, Zhang MZ, Li AQ, Wu ZT, Han Y, Li SR
Cytogenet Genome Res. 2008
PubMed ID: 18931482
Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repair.
Wu Q, Vasquez KM
PLoS Genet. 2008
PubMed ID: 18787700
MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis.
Holloway JK, Booth J, Edelmann W, McGowan CH, Cohen PE
PLoS Genet. 2008
PubMed ID: 18787696
Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study.
Brim H, Mokarram P, Naghibalhossaini F, Saberi-Firoozi M, Al-Mandhari M, Al-Mawaly K, Al-Mjeni R, Al-Sayegh A, Raeburn S, Lee E, Giardiello F, Smoot DT, Vilkin A, Boland CR, Goel A, Hafezi M, Nouraie M, Ashktorab H
Mol Cancer. 2008
PubMed ID: 18718023
The association between genetic variants in hMLH1 and hMSH2 and the development of sporadic colorectal cancer in the Danish population.
Christensen LL, Madsen BE, Wikman FP, Wiuf C, Koed K, Tjønneland A, Olsen A, Syvänen AC, Andersen CL, Orntoft TF
BMC Med Genet. 2008
PubMed ID: 18547406
Detection of mismatch repair gene germline mutation carrier among Chinese population with colorectal cancer.
Jin HY, Liu X, Li VK, Ding Y, Yang B, Geng J, Lai R, Ding S, Ni M, Zhao R
BMC Cancer. 2008
PubMed ID: 18257912
Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism in esophageal squamous cell carcinoma.
Wang J, Sasco AJ, Fu C, Xue H, Guo G, Hua Z, Zhou Q, Jiang Q, Xu B
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18199718
Mechanisms and functions of DNA mismatch repair.
Li GM
Cell Res. 2008
PubMed ID: 18157157
Fhit, Mlh1, P53 and phenotypic expression in the early stage of colorectal neoplasms.
Yasugi A, Yashima K, Hara A, Koda M, Kawaguchi K, Harada K, Andachi H, Murawaki Y
Oncol Rep. 2008
PubMed ID: 18097574
Validation and extension of the PREMM1,2 model in a population-based cohort of colorectal cancer patients.
Balaguer F, Balmaña J, Castellví-Bel S, Steyerberg EW, Andreu M, Llor X, Jover R, Syngal S, Castells A, Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
Gastroenterology. 2008
PubMed ID: 18061181
The extracolonic cancer spectrum in females with the common 'South African' hMLH1 c.C1528T mutation.
Blokhuis MM, Goldberg PA, Pietersen GE, Algar U, Vorster AA, Govender D, Ramesar RS
Fam Cancer. 2008
PubMed ID: 18049911
Mutant L Homologue 1 (MLH1): a possible new immunohistochemical marker for prostatic cancer.
Chuang ST, Adley B, Han M, Lin F, Yang XJ, Catalona WJ
Histopathology. 2008
PubMed ID: 18005136
Coexisting somatic promoter hypermethylation and pathogenic MLH1 germline mutation in Lynch syndrome.
Rahner N, Friedrichs N, Steinke V, Aretz S, Friedl W, Buettner R, Mangold E, Propping P, Walldorf C
J Pathol. 2008
PubMed ID: 17973250
Stage IV early gastric cancer: two cases with microsatellite instability.
An JY, Choi MG, Noh JH, Kim KM, Kim DS, Sohn TS, Kim S
Langenbecks Arch Surg. 2008
PubMed ID: 17917741
Thymosin beta 4 expression and nuclear transport are regulated by hMLH1.
Brieger A, Plotz G, Zeuzem S, Trojan J
Biochem Biophys Res Commun. 2007
PubMed ID: 17967441
Analysis of hMLH1 missense mutations in East Asian patients with suspected hereditary nonpolyposis colorectal cancer.
Fan Y, Wang W, Zhu M, Zhou J, Peng J, Xu L, Hua Z, Gao X, Wang Y
Clin Cancer Res. 2007
PubMed ID: 18094436
Two novel germline mutations of MLH1 and investigation of their pathobiology in hereditary non-polyposis colorectal cancer families in China.
Wang CF, Zhou XY, Zhang TM, Xu Y, Cai SJ, Shi DR
World J Gastroenterol. 2007
PubMed ID: 18069769
MSI is frequently recognized among gastric cancer patients with a family history of cancer.
Kanemitsu K, Kawasaki K, Nakamura M, Li D, Yasuda T, Kuroda D, Yokozaki H, Kamigaki T, Kuroda Y
Hepatogastroenterology. 2007
PubMed ID: 18265677
Left-Sided microsatellite unstable colorectal cancers show less frequent methylation of hMLH1 and CpG island methylator phenotype than right-sided ones.
Tanaka J, Watanabe T, Kanazawa T, Tada T, Kazama Y, Tanaka T, Nagawa H
J Surg Oncol. 2007
PubMed ID: 17786961
Assessment of MLH1 promoter methylation in relation to gene expression requires specific analysis.
Capel E, Fléjou JF, Hamelin R
Oncogene. 2007
PubMed ID: 17546041
Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island.
Lin JC, Jeong S, Liang G, Takai D, Fatemi M, Tsai YC, Egger G, Gal-Yam EN, Jones PA
Cancer Cell. 2007
PubMed ID: 17996647
Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair.
Schrader CE, Guikema JE, Linehan EK, Selsing E, Stavnezer J
J Immunol. 2007
PubMed ID: 17947680
Decreased expression of hMLH1 correlates with reduced 5-fluorouracil-mediated apoptosis in colon cancer cells.
Fujita H, Kato J, Horii J, Harada K, Hiraoka S, Shiraha H, Sakaguchi K, Shiratori Y
Oncol Rep. 2007
PubMed ID: 17914563
Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC).
Geary J, Sasieni P, Houlston R, Izatt L, Eeles R, Payne SJ, Fisher S, Hodgson SV
Fam Cancer. 2007
PubMed ID: 17939062
A single nucleotide substitution (-107C-->G) in the hMLH1 promoter found in colorectal cancer population reduces transcriptional activity.
Zhong X, Arita M, Yamada K, Sugiyama H, Tan K, Kanazawa S, Koike J, Teramoto T, Hemmi H
Biochem Genet. 2007
PubMed ID: 17690979
Microsatellite instability (MSI) and MLH1 and MSH2 protein expression analysis in postmenopausal women with sporadic endometrial cancer.
Sobczuk A, Romanowicz-Makowska H, Smolarz B, Pertynski T
J Exp Clin Cancer Res. 2007
PubMed ID: 17987798
Expression of Fhit, Mlh1, p16INK4A and E-cadherin in early gastric neoplasia: Correlation with histological grade and gastric phenotype.
Hara A, Yashima K, Yasugi A, Koda M, Kawaguchi K, Harada K, Andachi H, Shiota G, Ito H, Murawaki Y
Oncol Rep. 2007
PubMed ID: 17671701
[Significance of defects in the "mismatch repair system" for the development and course of prostate carcinoma]
Kneitz B, Ströbel P, Adam P, Edelmann W, Gerharz EW, Schartl M, Riedmiller H
Urologe A. 2007
PubMed ID: 17619846
Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis.
Li XC, Li X, Schimenti JC
PLoS Genet. 2007
PubMed ID: 17696610
Genetic investigation of DNA-repair pathway genes PMS2, MLH1, MSH2, MSH6, MUTYH, OGG1 and MTH1 in sporadic colon cancer.
Schafmayer C, Buch S, Egberts JH, Franke A, Brosch M, El Sharawy A, Conring M, Koschnick M, Schwiedernoch S, Katalinic A, Kremer B, Fölsch UR, Krawczak M, Fändrich F, Schreiber S, Tepel J, Hampe J
Int J Cancer. 2007
PubMed ID: 17417778
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells.
Peng M, Litman R, Xie J, Sharma S, Brosh RM, Cantor SB
EMBO J. 2007
PubMed ID: 17581638
Co-repression of mismatch repair gene expression by hypoxia in cancer cells: role of the Myc/Max network.
Bindra RS, Glazer PM
Cancer Lett. 2007
PubMed ID: 17275176
The additive effect of p53 Arg72Pro and RNASEL Arg462Gln genotypes on age of disease onset in Lynch syndrome patients with pathogenic germline mutations in MSH2 or MLH1.
Krüger S, Engel C, Bier A, Silber AS, Görgens H, Mangold E, Pagenstecher C, Holinski-Feder E, von Knebel Doeberitz M, Royer-Pokora B, Dechant S, Pox C, Rahner N, Müller A, Schackert HK, German HNPCC Consortium
Cancer Lett. 2007
PubMed ID: 17224235
Mechanisms of inactivation of MLH1 in hereditary nonpolyposis colorectal carcinoma: a novel approach.
Ollikainen M, Hannelius U, Lindgren CM, Abdel-Rahman WM, Kere J, Peltomäki P
Oncogene. 2007
PubMed ID: 17260015
Mismatch repair genes hMLH1 and hMSH2 may not play an essential role in breast carcinogenesis.
Khilko N, Bourne P, Qi Yang, Ping Tang
Int J Surg Pathol. 2007
PubMed ID: 17652529
Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample.
Ogino S, Kawasaki T, Kirkner GJ, Kraft P, Loda M, Fuchs CS
J Mol Diagn. 2007
PubMed ID: 17591929
Microsatellite instability and MLH1 hypermethylation - incidence and significance in colorectal polyps in young patients.
Koh DC, Luchtefeld MA, Kim DG, Attal H, Monroe T, Ingersoll K
Colorectal Dis. 2007
PubMed ID: 17573746
Aberrant DNA methylation in non-neoplastic gastric mucosa of H. Pylori infected patients and effect of eradication.
Perri F, Cotugno R, Piepoli A, Merla A, Quitadamo M, Gentile A, Pilotto A, Annese V, Andriulli A
Am J Gastroenterol. 2007
PubMed ID: 17509026
A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells.
Zeng X, Kinsella TJ
Autophagy. 2007
PubMed ID: 17426439
Assessment of microsatellite instability in colorectal carcinoma at an Indian center.
Pandey V, Prabhu JS, Payal K, Rajan V, Deepak C, Barde S, Jagannath P, Borges A, Sridhar TS
Int J Colorectal Dis. 2007
PubMed ID: 17160686
The role of chemotherapy in microsatellite unstable (MSI-H) colorectal cancer.
Warusavitarne J, Schnitzler M
Int J Colorectal Dis. 2007
PubMed ID: 17109103
[Screening the hereditary nonpolyposis colorectal cancer by revised Bethesda guideline: a cohort study of 110 cases]
Jin HY, Ding YJ, Liu XF, Yang BL, Lai RS, Ni M, Ge YS
Zhonghua Yi Xue Za Zhi. 2007
PubMed ID: 17785078
Significance and mechanism of microsatellite instability in laryngeal squamous cell carcinoma.
Zhigang H, Demin H, Han G, Erzhong F, Xiaohong C, Hongbo X
J Otolaryngol. 2007
PubMed ID: 17711772
[Microsatellite analysis and hMLH1/hMSH2 expression detection in young patients with colorectal cancer: value in screening hereditary nonpolyposis colorectal cancer]
Yang L, Ding YQ, Li GX, Yu J, Wang Y, Zhou J, Yang HJ, Zhang JH
Nan Fang Yi Ke Da Xue Xue Bao. 2007
PubMed ID: 17584637
Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR.
Bettstetter M, Dechant S, Ruemmele P, Grabowski M, Keller G, Holinski-Feder E, Hartmann A, Hofstaedter F, Dietmaier W
Clin Cancer Res. 2007
PubMed ID: 17545526
Genotype-phenotype correlations in individuals with a founder mutation in the MLH1 gene and hereditary non-polyposis colorectal cancer.
de Leon MP, Benatti P, Di Gregorio C, Losi L, Pedroni M, Ponti G, Genuardi M, Viel A, Lucci-Cordisco E, Rossi G, Roncucci L
Scand J Gastroenterol. 2007
PubMed ID: 17505997
Biallelic germline mutations of mismatch-repair genes: a possible cause for multiple pediatric malignancies.
Poley JW, Wagner A, Hoogmans MM, Menko FH, Tops C, Kros JM, Reddingius RE, Meijers-Heijboer H, Kuipers EJ, Dinjens WN, Rotterdam Initiative on Gastrointestinal Hereditary Tumors
Cancer. 2007
PubMed ID: 17440981
Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families: implications for genetic testing.
Papp J, Kovacs ME, Olah E
World J Gastroenterol. 2007
PubMed ID: 17569143
Functional analysis of human MLH1 variants using yeast and in vitro mismatch repair assays.
Takahashi M, Shimodaira H, Andreutti-Zaugg C, Iggo R, Kolodner RD, Ishioka C
Cancer Res. 2007
PubMed ID: 17510385
Ikaros is a mutational target for lymphomagenesis in Mlh1-deficient mice.
Kakinuma S, Kodama Y, Amasaki Y, Yi S, Tokairin Y, Arai M, Nishimura M, Monobe M, Kojima S, Shimada Y
Oncogene. 2007
PubMed ID: 17086208
A new interphase fluorescence in situ hybridization approach for genomic rearrangements involving MLH1 and MSH6 in hereditary nonpolyposis colorectal cancer-suspected mutation-negative patients.
Koehler U, Grabowski M, Bacher U, Holinski-Feder E
Cancer Genet Cytogenet. 2007
PubMed ID: 17498565
DNA mismatch repair protein expression and microsatellite instability in primary mucosal melanomas of the head and neck.
Marani C, Alvino E, Caporali S, Vigili MG, Mancini G, Rahimi S
Histopathology. 2007
PubMed ID: 17493242
Prevention of colorectal cancer by colonoscopic surveillance in families with hereditary colorectal cancer.
Stormorken AT, Clark N, Grindedal E, Maehle L, Møller P
Scand J Gastroenterol. 2007
PubMed ID: 17454882
Evidence for heritable predisposition to epigenetic silencing of MLH1.
Chen H, Taylor NP, Sotamaa KM, Mutch DG, Powell MA, Schmidt AP, Feng S, Hampel HL, de la Chapelle A, Goodfellow PJ
Int J Cancer. 2007
PubMed ID: 17230510
Microsatellite-unstable mucinous colorectal carcinoma occurring in the elderly: comparison with medullary type poorly differentiated adenocarcinoma.
Arai T, Kasahara I, Sawabe M, Kanazawa N, Kuroiwa K, Honma N, Aida J, Takubo K
Pathol Int. 2007
PubMed ID: 17316416
Mismatch repair polymorphisms and the risk of colorectal cancer.
Berndt SI, Platz EA, Fallin MD, Thuita LW, Hoffman SC, Helzlsouer KJ
Int J Cancer. 2007
PubMed ID: 17205513
Microsatellite instability and MLH1 promoter hypermethylation in colorectal cancer.
Niv Y
World J Gastroenterol. 2007
PubMed ID: 17465465
MLH1 -93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer.
Raptis S, Mrkonjic M, Green RC, Pethe VV, Monga N, Chan YM, Daftary D, Dicks E, Younghusband BH, Parfrey PS, Gallinger SS, McLaughlin JR, Knight JA, Bapat B
J Natl Cancer Inst. 2007
PubMed ID: 17374836
Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome.
Zipfel PF, Edey M, Heinen S, Józsi M, Richter H, Misselwitz J, Hoppe B, Routledge D, Strain L, Hughes AE, Goodship JA, Licht C, Goodship TH, Skerka C
PLoS Genet. 2007
PubMed ID: 17367211
Initiation and resolution of interhomolog connections: crossover and non-crossover sites along mouse synaptonemal complexes.
Moens PB, Marcon E, Shore JS, Kochakpour N, Spyropoulos B
J Cell Sci. 2007
PubMed ID: 17344431
Low frequency of promoter methylation of O6-methylguanine DNA methyltransferase and hMLH1 in ulcerative colitis-associated tumors: comparison with sporadic colonic tumors.
Mikami T, Yoshida T, Numata Y, Shiraishi H, Araki K, Guiot MC, Jass JR, Okayasu I
Am J Clin Pathol. 2007
PubMed ID: 17276933
Partial duplications of the MSH2 and MLH1 genes in hereditary nonpolyposis colorectal cancer.
Baert-Desurmont S, Buisine MP, Bessenay E, Frerot S, Lovecchio T, Martin C, Olschwang S, Wang Q, Frebourg T
Eur J Hum Genet. 2007
PubMed ID: 17228328
Small-bowel adenocarcinoma diagnosed via capsule endoscopy in a patient found to have hereditary nonpolyposis colorectal cancer.
Marmo R, Rotondano G, Riccio G, D'Angella R, Rescinito M, Rescinito A, Bianco MA, Cipolletta L
Gastrointest Endosc. 2007
PubMed ID: 17208239
Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics.
Lagerstedt Robinson K, Liu T, Vandrovcova J, Halvarsson B, Clendenning M, Frebourg T, Papadopoulos N, Kinzler KW, Vogelstein B, Peltomäki P, Kolodner RD, Nilbert M, Lindblom A
J Natl Cancer Inst. 2007
PubMed ID: 17312306
The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis.
Cherry SM, Adelman CA, Theunissen JW, Hassold TJ, Hunt PA, Petrini JH
Curr Biol. 2007
PubMed ID: 17291760
Inheritance of a cancer-associated MLH1 germ-line epimutation.
Hitchins MP, Wong JJ, Suthers G, Suter CM, Martin DI, Hawkins NJ, Ward RL
N Engl J Med. 2007
PubMed ID: 17301300
Inactivation of human mutL homolog 1 and mutS homolog 2 genes in head and neck squamous cell carcinoma tumors and leukoplakia samples by promoter hypermethylation and its relation with microsatellite instability phenotype.
Sengupta S, Chakrabarti S, Roy A, Panda CK, Roychoudhury S
Cancer. 2007
PubMed ID: 17219447
Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.
Cannavo E, Gerrits B, Marra G, Schlapbach R, Jiricny J
J Biol Chem. 2007
PubMed ID: 17148452
Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors.
Saydam N, Kanagaraj R, Dietschy T, Garcia PL, Peña-Diaz J, Shevelev I, Stagljar I, Janscak P
Nucleic Acids Res. 2007
PubMed ID: 17715146
Nine novel pathogenic germline mutations in MLH1, MSH2, MSH6 and PMS2 in families with Lynch syndrome.
Rahner N, Friedrichs N, Wehner M, Steinke V, Aretz S, Friedl W, Buettner R, Mangold E, Propping P, Walldorf C
Acta Oncol. 2007
PubMed ID: 17653898
A mononucleotide markers panel to identify hMLH1/hMSH2 germline mutations.
Pedroni M, Roncari B, Maffei S, Losi L, Scarselli A, Di Gregorio C, Marino M, Roncucci L, Benatti P, Ponti G, Rossi G, Menigatti M, Viel A, Genuardi M, de Leon MP
Dis Markers. 2007
PubMed ID: 17473388
Nationwide study of clinical and molecular features of hereditary non-polyposis colorectal cancer (HNPCC) in Latvia.
Irmejs A, Borosenko V, Melbarde-Gorkusa I, Gardovskis A, Bitina M, Kurzawski G, Suchy J, Gorski B, Gardovskis J
Anticancer Res. 2007
PubMed ID: 17348456
Novel hMSH2, hMSH6 and hMLH1 gene mutations and microsatellite instability in sporadic colorectal cancer.
Chaksangchaichot P, Punyarit P, Petmitr S
J Cancer Res Clin Oncol. 2007
PubMed ID: 16902769
Novel MLH1 frameshift mutation in an extended hereditary nonpolyposis colorectal cancer family.
Kadiyska TK, Kaneva RP, Nedin DG, Alexandrova AB, Gegova AT, Lalchev SG, Christova T, Mitev VI, Horst J, Bogdanova N, Kremensky IM
World J Gastroenterol. 2006
PubMed ID: 17203532
Germline mutations and polymorphic variants in MMR, E-cadherin and MYH genes associated with familial gastric cancer in Jiangsu of China.
Zhang Y, Liu X, Fan Y, Ding J, Xu A, Zhou X, Hu X, Zhu M, Zhang X, Li S, Wu J, Cao H, Li J, Wang Y
Int J Cancer. 2006
PubMed ID: 16929514
Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6.
Hegan DC, Narayanan L, Jirik FR, Edelmann W, Liskay RM, Glazer PM
Carcinogenesis. 2006
PubMed ID: 16728433
Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non-polyposis colorectal cancer.
Niessen RC, Berends MJ, Wu Y, Sijmons RH, Hollema H, Ligtenberg MJ, de Walle HE, de Vries EG, Karrenbeld A, Buys CH, van der Zee AG, Hofstra RM, Kleibeuker JH
Gut. 2006
PubMed ID: 16636019
Induction of aberrant crypt foci in DNA mismatch repair-deficient mice by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP).
Smith-Roe SL, Löhr CV, Bildfell RJ, Fischer KA, Hegan DC, Glazer PM, Buermeyer AB
Cancer Lett. 2006
PubMed ID: 16427736
DNA repair and cell cycle control genes and the risk of young-onset lung cancer.
Landi S, Gemignani F, Canzian F, Gaborieau V, Barale R, Landi D, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Gioia-Patricola L, Hall J, Boffetta P, Hung RJ, Brennan P
Cancer Res. 2006
PubMed ID: 17108146
Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages.
Liebe B, Petukhova G, Barchi M, Bellani M, Braselmann H, Nakano T, Pandita TK, Jasin M, Fornace A, Meistrich ML, Baarends WM, Schimenti J, de Lange T, Keeney S, Camerini-Otero RD, Scherthan H
Exp Cell Res. 2006
PubMed ID: 17010969
Single-nucleotide polymorphisms of mismatch repair genes in healthy Chinese individuals and sporadic colorectal cancer patients.
Mei Q, Yan HL, Ding FX, Xue G, Huang JJ, Wang YZ, Sun SH
Cancer Genet Cytogenet. 2006
PubMed ID: 17074586
Common variants in mismatch repair genes and risk of invasive ovarian cancer.
Song H, Ramus SJ, Quaye L, DiCioccio RA, Tyrer J, Lomas E, Shadforth D, Hogdall E, Hogdall C, McGuire V, Whittemore AS, Easton DF, Ponder BA, Kjaer SK, Pharoah PD, Gayther SA
Carcinogenesis. 2006
PubMed ID: 16774946
Variations in exon 7 of the MSH2 gene and susceptibility to gastrointestinal cancer in a Chinese population.
Fan Y, Liu X, Zhang H, Dai J, Zhang X, Zhu M, Gao X, Wang Y
Cancer Genet Cytogenet. 2006
PubMed ID: 17011982
Atypical haemolytic uraemic syndrome associated with a hybrid complement gene.
Venables JP, Strain L, Routledge D, Bourn D, Powell HM, Warwicker P, Diaz-Torres ML, Sampson A, Mead P, Webb M, Pirson Y, Jackson MS, Hughes A, Wood KM, Goodship JA, Goodship TH
PLoS Med. 2006
PubMed ID: 17076561
Age-related alteration in the association of microsatellite instability with absent hMLH1 expression and histological types of colorectal carcinoma.
Arai T, Sugai T, Kasahara I, Sawabe M, Honma N, Aida J, Nakamura S, Takubo K
Pathol Int. 2006
PubMed ID: 16984616
Loss of hMLH1 expression is associated with less aggressive clinicopathological features in sporadic endometrioid endometrial adenocarcinoma.
Ju W, Park HM, Lee SN, Sung SH, Kim SC
J Obstet Gynaecol Res. 2006
PubMed ID: 16984511
Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex.
Hamer G, Gell K, Kouznetsova A, Novak I, Benavente R, Höög C
J Cell Sci. 2006
PubMed ID: 16968740
MSH6 germline mutations in early-onset colorectal cancer patients without family history of the disease.
Pinto C, Veiga I, Pinheiro M, Mesquita B, Jeronimo C, Sousa O, Fragoso M, Santos L, Moreira-Dias L, Baptista M, Lopes C, Castedo S, Teixeira MR
Br J Cancer. 2006
PubMed ID: 16940983
Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel.
Brücher BL, Geddert H, Langner C, Höfler H, Fink U, Siewert JR, Sarbia M
Int J Cancer. 2006
PubMed ID: 16619216
Genotype-phenotype comparison of German MLH1 and MSH2 mutation carriers clinically affected with Lynch syndrome: a report by the German HNPCC Consortium.
Goecke T, Schulmann K, Engel C, Holinski-Feder E, Pagenstecher C, Schackert HK, Kloor M, Kunstmann E, Vogelsang H, Keller G, Dietmaier W, Mangold E, Friedrichs N, Propping P, Krüger S, Gebert J, Schmiegel W, Rueschoff J, Loeffler M, Moeslein G, German HNPCC Consortium
J Clin Oncol. 2006
PubMed ID: 16908935
Endometrial cancer risk is associated with variants of the mismatch repair genes MLH1 and MSH2.
Beiner ME, Rosen B, Fyles A, Harley I, Pal T, Siminovitch K, Zhang S, Sun P, Narod SA
Cancer Epidemiol Biomarkers Prev. 2006
PubMed ID: 16985024
DNA repair pathway profiling and microsatellite instability in colorectal cancer.
Yu J, Mallon MA, Zhang W, Freimuth RR, Marsh S, Watson MA, Goodfellow PJ, McLeod HL
Clin Cancer Res. 2006
PubMed ID: 16951227
Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients.
Hampel H, Frankel W, Panescu J, Lockman J, Sotamaa K, Fix D, Comeras I, La Jeunesse J, Nakagawa H, Westman JA, Prior TW, Clendenning M, Penzone P, Lombardi J, Dunn P, Cohn DE, Copeland L, Eaton L, Fowler J, Lewandowski G, Vaccarello L, Bell J, Reid G, de la Chapelle A
Cancer Res. 2006
PubMed ID: 16885385
Variation in MLH1 distribution in recombination maps for individual chromosomes from human males.
Sun F, Oliver-Bonet M, Liehr T, Starke H, Turek P, Ko E, Rademaker A, Martin RH
Hum Mol Genet. 2006
PubMed ID: 16803849
Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking.
Brand RM, Jones DD, Lynch HT, Brand RE, Watson P, Ashwathnayaran R, Roy HK
World J Gastroenterol. 2006
PubMed ID: 16874859
Endonucleolytic function of MutLalpha in human mismatch repair.
Kadyrov FA, Dzantiev L, Constantin N, Modrich P
Cell. 2006
PubMed ID: 16873062
MutLalpha: at the cutting edge of mismatch repair.
Jiricny J
Cell. 2006
PubMed ID: 16873053
Clinical and genetic characteristics of Chinese hereditary nonpolyposis colorectal cancer families.
Wang XL, Yuan Y, Zhang SZ, Cai SR, Huang YQ, Jiang Q, Zheng S
World J Gastroenterol. 2006
PubMed ID: 16810763
Loss of protein expression of hMLH1 and hMSH2 with double primary carcinomas of the stomach and colorectum.
Yamamoto M, Taguchi K, Baba H, Endo K, Kohnoe S, Okamura T, Maehara Y
Oncol Rep. 2006
PubMed ID: 16786121
Assessing the pathogenicity of MLH1 missense mutations in patients with suspected hereditary nonpolyposis colorectal cancer: correlation with clinical, genetic and functional features.
Belvederesi L, Bianchi F, Loretelli C, Gagliardini D, Galizia E, Bracci R, Rosati S, Bearzi I, Viel A, Cellerino R, Porfiri E
Eur J Hum Genet. 2006
PubMed ID: 16724012
Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer.
Barnetson RA, Tenesa A, Farrington SM, Nicholl ID, Cetnarskyj R, Porteous ME, Campbell H, Dunlop MG
N Engl J Med. 2006
PubMed ID: 16807412
Immunohistochemical expression of mismatch repair genes: a screening tool for predicting mutator phenotype in liver fluke infection-associated intrahepatic cholangiocarcinoma.
Liengswangwong U, Karalak A, Morishita Y, Noguchi M, Khuhaprema T, Srivatanakul P, Miwa M
World J Gastroenterol. 2006
PubMed ID: 16773692
Mismatch repair polymorphisms and colorectal polyps: hMLH1-93G>A variant modifies risk associated with smoking.
Yu JH, Bigler J, Whitton J, Potter JD, Ulrich CM
Am J Gastroenterol. 2006
PubMed ID: 16771955
Germ line mutations of mismatch repair genes in hereditary nonpolyposis colorectal cancer patients with small bowel cancer: International Society for Gastrointestinal Hereditary Tumours Collaborative Study.
Park JG, Kim DW, Hong CW, Nam BH, Shin YK, Hong SH, Kim IJ, Lim SB, Aronson M, Bisgaard ML, Brown GJ, Burn J, Chow E, Conrad P, Douglas F, Dunlop M, Ford J, Greenblatt MS, Heikki J, Heinimann K, Lynch EL, Macrae F, McKinnon WC, Möeslein G, Rossi BM, Rozen P, Schofield L, Vaccaro C, Vasen H, Velthuizen M, Viel A, Wijnen J, International Society for Gastrointestinal Hereditary Tumours
Clin Cancer Res. 2006
PubMed ID: 16740762
Immunohistochemistry detects mismatch repair gene defects in colorectal cancer.
Hameed F, Goldberg PA, Hall P, Algar U, van Wijk R, Ramesar R
Colorectal Dis. 2006
PubMed ID: 16684085
Microsatellite instability and methylation of the DNA mismatch repair genes in head and neck cancer.
Demokan S, Suoglu Y, Demir D, Gozeler M, Dalay N
Ann Oncol. 2006
PubMed ID: 16569647
Sohlh1 is essential for spermatogonial differentiation.
Ballow D, Meistrich ML, Matzuk M, Rajkovic A
Dev Biol. 2006
PubMed ID: 16564520
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts.
Yoshioka K, Yoshioka Y, Hsieh P
Mol Cell. 2006
PubMed ID: 16713580
Age of diagnosis of colorectal cancer in HNPCC patients is more complex than that predicted by R72P polymorphism in TP53.
Talseth BA, Meldrum C, Suchy J, Kurzawski G, Lubinski J, Scott RJ
Int J Cancer. 2006
PubMed ID: 16353134
Clinical performance of original and revised Bethesda guidelines for the identification of MSH2/MLH1 gene carriers in patients with newly diagnosed colorectal cancer: proposal of a new and simpler set of recommendations.
Rodríguez-Moranta F, Castells A, Andreu M, Piñol V, Castellví-Bel S, Alenda C, Llor X, Xicola RM, Jover R, Payá A, Bessa X, Balaguer F, Cubiella J, Argüello L, Morillas JD, Bujanda L, Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
Am J Gastroenterol. 2006
PubMed ID: 16696788
The DNA sequence, annotation and analysis of human chromosome 3.
Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA
Nature. 2006
PubMed ID: 16641997
HOXA5 regulates hMLH1 expression in breast cancer cells.
Duriseti S, Winnard PT, Mironchik Y, Vesuna F, Raman A, Raman V
Neoplasia. 2006
PubMed ID: 16756717
Accelerated growth of intestinal tumours after radiation exposure in Mlh1-knockout mice: evaluation of the late effect of radiation on a mouse model of HNPCC.
Tokairin Y, Kakinuma S, Arai M, Nishimura M, Okamoto M, Ito E, Akashi M, Miki Y, Kawano T, Iwai T, Shimada Y
Int J Exp Pathol. 2006
PubMed ID: 16623753
Distinct patterns of germ-line deletions in MLH1 and MSH2: the implication of Alu repetitive element in the genetic etiology of Lynch syndrome (HNPCC).
Li L, McVety S, Younan R, Liang P, Du Sart D, Gordon PH, Hutter P, Hogervorst FB, Chong G, Foulkes WD
Hum Mutat. 2006
PubMed ID: 16541406
Association between the MLH1 gene and longevity.
Kim DJ, Yi SM, Lee SY, Kang HS, Choi YH, Song YW, Park SC
Hum Genet. 2006
PubMed ID: 16474933
DNA methylation in esophageal diseases including cancer: special reference to hMLH1 gene promoter status.
Vasavi M, Ponnala S, Gujjari K, Boddu P, Bharatula RS, Prasad R, Ahuja YR, Hasan Q
Tumori. 2006
PubMed ID: 16724696
Promoter methylation profile in gallbladder cancer.
Roa JC, Anabalón L, Roa I, Melo A, Araya JC, Tapia O, de Aretxabala X, Muñoz S, Schneider B
J Gastroenterol. 2006
PubMed ID: 16699861
Hypermethylation of the MLH1 promoter with concomitant absence of transcript and protein occurs in small patches of crypt cells in unaffected mucosa from sporadic colorectal carcinoma.
Nuovo GJ, Nakagawa H, Sotamaa K, Chapelle Ade L
Diagn Mol Pathol. 2006
PubMed ID: 16531764
Aberrant splicing in MLH1 and MSH2 due to exonic and intronic variants.
Pagenstecher C, Wehner M, Friedl W, Rahner N, Aretz S, Friedrichs N, Sengteller M, Henn W, Buettner R, Propping P, Mangold E
Hum Genet. 2006
PubMed ID: 16341550
Mlh1-dependent suppression of specific mutations induced in vivo by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP).
Smith-Roe SL, Hegan DC, Glazer PM, Buermeyer AB
Mutat Res. 2006
PubMed ID: 16256150
Analysis of the human MutLalpha.MutSalpha complex.
Plotz G, Piiper A, Wormek M, Zeuzem S, Raedle J
Biochem Biophys Res Commun. 2006
PubMed ID: 16403449
Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer.
Fox EJ, Leahy DT, Geraghty R, Mulcahy HE, Fennelly D, Hyland JM, O'Donoghue DP, Sheahan K
J Mol Diagn. 2006
PubMed ID: 16436636
Mismatch repair genes in renal cortical neoplasms.
Baiyee D, Banner B
Hum Pathol. 2006
PubMed ID: 16426918
Systematic mRNA analysis for the effect of MLH1 and MSH2 missense and silent mutations on aberrant splicing.
Auclair J, Busine MP, Navarro C, Ruano E, Montmain G, Desseigne F, Saurin JC, Lasset C, Bonadona V, Giraud S, Puisieux A, Wang Q
Hum Mutat. 2006
PubMed ID: 16395668
Molecular alterations of monophasic synovial sarcoma: loss of chromosome 3p does not alter RASSF1 and MLH1 transcriptional activity.
Pazzaglia L, Benassi MS, Ragazzini P, Gamberi G, Ponticelli F, Chiechi A, Hattinger CM, Morandi L, Alberghini M, Zanella L, Picci P, Mercuri M
Histol Histopathol. 2006
PubMed ID: 16329043
Disruption of an exon splicing enhancer in exon 3 of MLH1 is the cause of HNPCC in a Quebec family.
McVety S, Li L, Gordon PH, Chong G, Foulkes WD
J Med Genet. 2006
PubMed ID: 15923275
Identification of a splicing enhancer in MLH1 using COMPARE, a new assay for determination of relative RNA splicing efficiencies.
Xu DQ, Mattox W
Hum Mol Genet. 2006
PubMed ID: 16357104
Mild inflammation accelerates colon carcinogenesis in Mlh1-deficient mice.
Taniguchi K, Kakinuma S, Tokairin Y, Arai M, Kohno H, Wakabayashi K, Imaoka T, Ito E, Koike M, Uetake H, Nishimura M, Yamauchi K, Sugihara K, Shimada Y
Oncology. 2006
PubMed ID: 17347588
Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair.
Plotz G, Welsch C, Giron-Monzon L, Friedhoff P, Albrecht M, Piiper A, Biondi RM, Lengauer T, Zeuzem S, Raedle J
Nucleic Acids Res. 2006
PubMed ID: 17135187
Frequency of hereditary non-polyposis colorectal cancer among unselected patients with colorectal cancer in Germany.
Lamberti C, Mangold E, Pagenstecher C, Jungck M, Schwering D, Bollmann M, Vogel J, Kindermann D, Nikorowitsch R, Friedrichs N, Schneider B, Houshdaran F, Schmidt-Wolf IG, Friedl W, Propping P, Sauerbruch T, Büttner R, Mathiak M
Digestion. 2006
PubMed ID: 17095871
In silico and in vivo splicing analysis of MLH1 and MSH2 missense mutations shows exon- and tissue-specific effects.
Lastella P, Surdo NC, Resta N, Guanti G, Stella A
BMC Genomics. 2006
PubMed ID: 16995940
EASI--enrichment of alternatively spliced isoforms.
Venables JP, Burn J
Nucleic Acids Res. 2006
PubMed ID: 16951290
PPARdelta status and mismatch repair mediated neoplasia in the mouse intestine.
Reed KR, Sansom OJ, Hayes AJ, Gescher AJ, Peters JM, Clarke AR
BMC Cancer. 2006
PubMed ID: 16672050
Germline MSH2 and MLH1 mutational spectrum including large rearrangements in HNPCC families from Poland (update study).
Kurzawski G, Suchy J, Lener M, Kłujszo-Grabowska E, Kładny J, Safranow K, Jakubowska K, Jakubowska A, Huzarski T, Byrski T, Debniak T, Cybulski C, Gronwald J, Oszurek O, Oszutowska D, Kowalska E, Góźdź S, Niepsuj S, Słomski R, Pławski A, Łacka-Wojciechowska A, Rozmiarek A, Fiszer-Maliszewska Ł, Bebenek M, Sorokin D, Sasiadek MM, Stembalska A, Grzebieniak Z, Kilar E, Stawicka M, Godlewski D, Richter P, Brozek I, Wysocka B, Limon J, Jawień A, Banaszkiewicz Z, Janiszewska H, Kowalczyk J, Czudowska D, Scott RJ, Lubiński J
Clin Genet. 2006
PubMed ID: 16451135
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.
Greenberg RA, Sobhian B, Pathania S, Cantor SB, Nakatani Y, Livingston DM
Genes Dev. 2006
PubMed ID: 16391231
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Human mismatch repair: reconstitution of a nick-directed bidirectional reaction.
Constantin N, Dzantiev L, Kadyrov FA, Modrich P
J Biol Chem. 2005
PubMed ID: 16188885
High concentration of deoxycholic acid abrogates in vitro transformation of IEC6 intestinal cells by azoxymethane.
Sasaki T, Shimura H, Sasahira T, Fujii K, Kuniyasu H
J Exp Clin Cancer Res. 2005
PubMed ID: 16471326
The analysis for identifying large DNA fragment aberrations of MSH2 and MLH1 genes from familial colorectal cancer in China.
Zhu M, Liu XR, Huang YQ, Yuan Y, Li JT, Zhang XM, Zhang YY, Wang YP
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005
PubMed ID: 16331552
Use of mononucleotide repeat markers for detection of microsatellite instability in mouse tumors.
Bacher JW, Abdel Megid WM, Kent-First MG, Halberg RB
Mol Carcinog. 2005
PubMed ID: 16240453
Association of cytokine and DNA repair gene polymorphisms with hepatitis B-related hepatocellular carcinoma.
Chen CC, Yang SY, Liu CJ, Lin CL, Liaw YF, Lin SM, Lee SD, Chen PJ, Chen CJ, Yu MW
Int J Epidemiol. 2005
PubMed ID: 16172101
Crossover and noncrossover pathways in mouse meiosis.
Guillon H, Baudat F, Grey C, Liskay RM, de Massy B
Mol Cell. 2005
PubMed ID: 16307920
Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I.
Kolas NK, Svetlanov A, Lenzi ML, Macaluso FP, Lipkin SM, Liskay RM, Greally J, Edelmann W, Cohen PE
J Cell Biol. 2005
PubMed ID: 16260499
Influence of hMLH1 methylation, mismatch repair deficiency and microsatellite instability on chemoresistance of testicular germ-cell tumors.
Olasz J, Mándoky L, Géczi L, Bodrogi I, Csuka O, Bak M
Anticancer Res. 2005
PubMed ID: 16309235
MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer.
Hitchins M, Williams R, Cheong K, Halani N, Lin VA, Packham D, Ku S, Buckle A, Hawkins N, Burn J, Gallinger S, Goldblatt J, Kirk J, Tomlinson I, Scott R, Spigelman A, Suter C, Martin D, Suthers G, Ward R
Gastroenterology. 2005
PubMed ID: 16285940
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
Assay validation for identification of hereditary nonpolyposis colon cancer-causing mutations in mismatch repair genes MLH1, MSH2, and MSH6.
Hegde M, Blazo M, Chong B, Prior T, Richards C
J Mol Diagn. 2005
PubMed ID: 16237223
Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.
Chen PC, Dudley S, Hagen W, Dizon D, Paxton L, Reichow D, Yoon SR, Yang K, Arnheim N, Liskay RM, Lipkin SM
Cancer Res. 2005
PubMed ID: 16204034
High frequency of hereditary colorectal cancer in Newfoundland likely involves novel susceptibility genes.
Woods MO, Hyde AJ, Curtis FK, Stuckless S, Green JS, Pollett AF, Robb JD, Green RC, Croitoru ME, Careen A, Chaulk JA, Jegathesan J, McLaughlin JR, Gallinger SS, Younghusband HB, Bapat BV, Parfrey PS
Clin Cancer Res. 2005
PubMed ID: 16203774
Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.
Ziv S, Brenner O, Amariglio N, Smorodinsky NI, Galron R, Carrion DV, Zhang W, Sharma GG, Pandita RK, Agarwal M, Elkon R, Katzin N, Bar-Am I, Pandita TK, Kucherlapati R, Rechavi G, Shiloh Y, Barzilai A
Hum Mol Genet. 2005
PubMed ID: 16150740
Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer.
Southey MC, Jenkins MA, Mead L, Whitty J, Trivett M, Tesoriero AA, Smith LD, Jennings K, Grubb G, Royce SG, Walsh MD, Barker MA, Young JP, Jass JR, St John DJ, Macrae FA, Giles GG, Hopper JL
J Clin Oncol. 2005
PubMed ID: 16116158
Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancer.
Mangold E, Pagenstecher C, Friedl W, Mathiak M, Buettner R, Engel C, Loeffler M, Holinski-Feder E, Müller-Koch Y, Keller G, Schackert HK, Krüger S, Goecke T, Moeslein G, Kloor M, Gebert J, Kunstmann E, Schulmann K, Rüschoff J, Propping P
Int J Cancer. 2005
PubMed ID: 15849733
Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice.
Yang K, Fan KH, Lamprecht SA, Edelmann W, Kopelovich L, Kucherlapati R, Lipkin M
Int J Cancer. 2005
PubMed ID: 15818612
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Chromoendoscopic colonoscopy for detecting preneoplastic lesions in hereditary nonpolyposis colorectal cancer syndrome.
Lecomte T, Cellier C, Meatchi T, Barbier JP, Cugnenc PH, Jian R, Laurent-Puig P, Landi B
Clin Gastroenterol Hepatol. 2005
PubMed ID: 16234028
Characterization of hMLH1 and hMSH2 gene dosage alterations in Lynch syndrome patients.
Baudhuin LM, Ferber MJ, Winters JL, Steenblock KJ, Swanson RL, French AJ, Butz ML, Thibodeau SN
Gastroenterology. 2005
PubMed ID: 16143124
Expression of mismatch repair enzymes, hMLH1 and hMSH2 is not associated with microsatellite instability and P53 protein accumulation in basal cell carcinoma.
Saetta AA, Aroni K, Stamatelli A, Lazaris AC, Patsouris E
Arch Dermatol Res. 2005
PubMed ID: 16012876
Low allele frequency of MLH1 D132H in American colorectal and endometrial cancer patients.
Shin BY, Chen H, Rozek LS, Paxton L, Peel DJ, Anton-Culver H, Rennert G, Mutch DG, Goodfellow PJ, Gruber SB, Lipkin SM
Dis Colon Rectum. 2005
PubMed ID: 15991064
Mouse models expressing human carcinoembryonic antigen (CEA) as a transgene: evaluation of CEA-based cancer vaccines.
Hance KW, Zeytin HE, Greiner JW
Mutat Res. 2005
PubMed ID: 15888344
The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers.
Lawes DA, Pearson T, Sengupta S, Boulos PB
Br J Cancer. 2005
PubMed ID: 16106253
Functional significance and clinical phenotype of nontruncating mismatch repair variants of MLH1.
Raevaara TE, Korhonen MK, Lohi H, Hampel H, Lynch E, Lönnqvist KE, Holinski-Feder E, Sutter C, McKinnon W, Duraisamy S, Gerdes AM, Peltomäki P, Kohonen-Ccorish M, Mangold E, Macrae F, Greenblatt M, de la Chapelle A, Nyström M
Gastroenterology. 2005
PubMed ID: 16083711
Promoter hypermethylation is the predominant mechanism in hMLH1 and hMSH2 deregulation and is a poor prognostic factor in nonsmoking lung cancer.
Hsu HS, Wen CK, Tang YA, Lin RK, Li WY, Hsu WH, Wang YC
Clin Cancer Res. 2005
PubMed ID: 16061855
Clinical and molecular characteristics of hereditary non-polyposis colorectal cancer families in Southeast Asia.
Lee SC, Guo JY, Lim R, Soo R, Koay E, Salto-Tellez M, Leong A, Goh BC
Clin Genet. 2005
PubMed ID: 15996210
Foxl2 is required for commitment to ovary differentiation.
Ottolenghi C, Omari S, Garcia-Ortiz JE, Uda M, Crisponi L, Forabosco A, Pilia G, Schlessinger D
Hum Mol Genet. 2005
PubMed ID: 15944199
Genomic rearrangements in MSH2 and MLH1 are rare mutational events in Spanish patients with hereditary nonpolyposis colorectal cancer.
Castellví-Bel S, Castells A, Strunk M, Ferrández A, Piazuelo E, Milà M, Piñol V, Rodríguez-Moranta F, Andreu M, Lanas A, Piqué JM, Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
Cancer Lett. 2005
PubMed ID: 16003840
Frequency of hereditary non-polyposis colorectal cancer among Uruguayan patients with colorectal cancer.
Sarroca C, Valle AD, Fresco R, Renkonen E, Peltömaki P, Lynch H
Clin Genet. 2005
PubMed ID: 15952990
Methylation of the MLH1 gene in hematological malignancies.
Matsushita M, Takeuchi S, Yang Y, Yoshino N, Tsukasaki K, Taguchi H, Koeffler HP, Seo H
Oncol Rep. 2005
PubMed ID: 15944788
Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus.
Shakib K, Norman JT, Fine LG, Brown LR, Godovac-Zimmermann J
Proteomics. 2005
PubMed ID: 15942958
Accuracy of MSI testing in predicting germline mutations of MSH2 and MLH1: a case study in Bayesian meta-analysis of diagnostic tests without a gold standard.
Chen S, Watson P, Parmigiani G
Biostatistics. 2005
PubMed ID: 15831578
Diethylstilbestrol effects and lymphomagenesis in Mlh1-deficient mice.
Kabbarah O, Sotelo AK, Mallon MA, Winkeler EL, Fan MY, Pfeifer JD, Shibata D, Gutmann DH, Goodfellow PJ
Int J Cancer. 2005
PubMed ID: 15700306
Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk.
Lee KM, Choi JY, Kang C, Kang CP, Park SK, Cho H, Cho DY, Yoo KY, Noh DY, Ahn SH, Park CG, Wei Q, Kang D
Clin Cancer Res. 2005
PubMed ID: 15958648
BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes.
Domingo E, Niessen RC, Oliveira C, Alhopuro P, Moutinho C, Espín E, Armengol M, Sijmons RH, Kleibeuker JH, Seruca R, Aaltonen LA, Imai K, Yamamoto H, Schwartz S, Hofstra RM
Oncogene. 2005
PubMed ID: 15782118
Effect of Helicobacter pylori infection on the expression of DNA mismatch repair protein.
Park DI, Park SH, Kim SH, Kim JW, Cho YK, Kim HJ, Sohn CI, Jeon WK, Kim BI, Cho EY, Kim EJ, Chae SW, Sohn JH, Sung IK, Sepulveda AR, Kim JJ
Helicobacter. 2005
PubMed ID: 15904475
Immunohistochemical detection of hMLH1 and hMSH2 proteins in vulvar carcinoma.
Kwasniewska A, Postawski K, Gozdzicka-Józefiak A, Zdunek M, Korobowicz E, Miturski R
Int J Mol Med. 2005
PubMed ID: 15870899
Mismatch repair gene promoter methylation and expression in hydatidiform moles.
Chen H, Ye D, Xie X, Lu W, Zhu C, Chen X
Arch Gynecol Obstet. 2005
PubMed ID: 15338238
HMLH1 gene mutation in gastric cancer patients and their kindred.
Li JH, Shi XZ, Lü S, Liu M, Cui WM, Liu LN, Jiang J, Xu GW
World J Gastroenterol. 2005
PubMed ID: 15918206
Identification of predictive factors for the occurrence of predisposing MLH1 and MSH2 germline mutations among Sardinian patients with colorectal carcinoma.
Colombino M, Cossu A, Budroni M, Satta MP, Baldinu P, Casula M, Palomba G, Pisano M, Sini MC, Deiana A, Tanda F, Palmieri G
Eur J Cancer. 2005
PubMed ID: 15862756
Analysis of hMLH1 and hMSH2 gene dosage alterations in hereditary nonpolyposis colorectal cancer patients by novel methods.
Baudhuin LM, Mai M, French AJ, Kruckeberg KE, Swanson RL, Winters JL, Courteau LK, Thibodeau SN
J Mol Diagn. 2005
PubMed ID: 15858146
Characterization of the nuclear import of human MutLalpha.
Brieger A, Plotz G, Raedle J, Weber N, Baum W, Caspary WF, Zeuzem S, Trojan J
Mol Carcinog. 2005
PubMed ID: 15754314
Clinicopathological and molecular genetic analysis of HNPCC in China.
Luo DC, Cai Q, Sun MH, Ni YZ, Ni SC, Chen ZJ, Li XY, Tao CW, Zhang XM, Shi DR
World J Gastroenterol. 2005
PubMed ID: 15786548
Psychological impact of genetic testing for hereditary nonpolyposis colorectal cancer.
Gritz ER, Peterson SK, Vernon SW, Marani SK, Baile WF, Watts BG, Amos CI, Frazier ML, Lynch PM
J Clin Oncol. 2005
PubMed ID: 15774782
Correlation between hMLH1/hMSH2 and p53 protein expression in sporadic colorectal cancer.
Park IJ, Kim HC, Kim JS, Yu ES, Yu CS, Kim JC
Hepatogastroenterology. 2005
PubMed ID: 15816455
The mechanism of microsatellite instability is different in synchronous and metachronous colorectal cancer.
Velayos FS, Lee SH, Qiu H, Dykes S, Yiu R, Terdiman JP, Garcia-Aguilar J
J Gastrointest Surg. 2005
PubMed ID: 15749592
Conversion analysis for mutation detection in MLH1 and MSH2 in patients with colorectal cancer.
Casey G, Lindor NM, Papadopoulos N, Thibodeau SN, Moskow J, Steelman S, Buzin CH, Sommer SS, Collins CE, Butz M, Aronson M, Gallinger S, Barker MA, Young JP, Jass JR, Hopper JL, Diep A, Bapat B, Salem M, Seminara D, Haile R, Colon Cancer Family Registry
JAMA. 2005
PubMed ID: 15713769
Expression of the hMLH1 and hMSH2 proteins in normal tissues: relationship to cancer predisposition in hereditary non-polyposis colon cancer.
Plevová P, Sedláková E, Zapletalová J, Krepelová A, Skýpalová P, Kolár Z
Virchows Arch. 2005
PubMed ID: 15735976
[Large genomic deletions of mismatch repair genes in Chinese patients with hereditary nonpolyposis colorectal cancer]
Haung YQ, Yuan Y, Wang YP, Zhu M, Zhang SZ, Zheng S
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005
PubMed ID: 15696491
Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants.
Di Giacomo M, Barchi M, Baudat F, Edelmann W, Keeney S, Jasin M
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15640358
Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.
Lüchtenborg M, Weijenberg MP, Wark PA, Saritas AM, Roemen GM, van Muijen GN, de Bruïne AP, van den Brandt PA, de Goeij AF
BMC Cancer. 2005
PubMed ID: 16356174
Microsatellite instability caused by hMLH1 promoter methylation increases with tumor progression in right-sided sporadic colorectal cancer.
Noda H, Kato Y, Yoshikawa H, Arai M, Togashi K, Nagai H, Konishi F, Miki Y
Oncology. 2005
PubMed ID: 16293975
Microsatellite instability is linked to loss of hMLH1 expression in advanced gastric cancers: lack of a relationship with the histological type and phenotype.
Mizoshita T, Tsukamoto T, Cao X, Otsuka T, Ito S, Takahashi E, Nakamura S, Nakamura T, Yamamura Y, Tatematsu M
Gastric Cancer. 2005
PubMed ID: 16086119
Gene knockouts that cause female infertility: search for novel contraceptive targets.
Naz RK, Rajesh C
Front Biosci. 2005
PubMed ID: 15970507
Defective DNA mismatch repair in long-term (> or =3 years) survivors with pancreatic cancer.
Maple JT, Smyrk TC, Boardman LA, Johnson RA, Thibodeau SN, Chari ST
Pancreatology. 2005
PubMed ID: 15855819
Altered expression of the DNA mismatch repair proteins hMLH1 and hMSH2 in cutaneous dysplastic nevi and malignant melanoma.
Shpitz B, Klein E, Malinger P, Osmolovsky G, Gochberg S, Bomstein Y, Bernheim J
Int J Biol Markers. 2005
PubMed ID: 15832775
Immunohistochemical expression of DNA mismatch repair (MMR) system proteins (hMLH1, hMSH2) in cervical preinvasive and invasive lesions.
Ciavattini A, Piccioni M, Tranquilli AL, Filosa A, Pieramici T, Goteri G
Pathol Res Pract. 2005
PubMed ID: 15807307
Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability.
Oda S, Maehara Y, Ikeda Y, Oki E, Egashira A, Okamura Y, Takahashi I, Kakeji Y, Sumiyoshi Y, Miyashita K, Yamada Y, Zhao Y, Hattori H, Taguchi K, Ikeuchi T, Tsuzuki T, Sekiguchi M, Karran P, Yoshida MA
Nucleic Acids Res. 2005
PubMed ID: 15778432
Value of immunohistochemical detection of DNA mismatch repair proteins in predicting germline mutation in hereditary colorectal neoplasms.
Shia J, Klimstra DS, Nafa K, Offit K, Guillem JG, Markowitz AJ, Gerald WL, Ellis NA
Am J Surg Pathol. 2005
PubMed ID: 15613860
The profile of hMLH1 methylation and microsatellite instability in colorectal and non-small cell lung cancer.
Okuda T, Kawakami K, Ishiguro K, Oda M, Omura K, Watanabe G
Int J Mol Med. 2005
PubMed ID: 15583832
Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis i in human oocytes.
Lenzi ML, Smith J, Snowden T, Kim M, Fishel R, Poulos BK, Cohen PE
Am J Hum Genet. 2005
PubMed ID: 15558497
Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome).
Watson P, Ashwathnarayan R, Lynch HT, Roy HK
Arch Intern Med. 2004
PubMed ID: 15596632
Mlh1 mediates tissue-specific regulation of mitotic recombination.
Shao C, Deng L, Chen Y, Kucherlapati R, Stambrook PJ, Tischfield JA
Oncogene. 2004
PubMed ID: 15480418
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Six novel heterozygous MLH1, MSH2, and MSH6 and one homozygous MLH1 germline mutations in hereditary nonpolyposis colorectal cancer.
Rey JM, Noruzinia M, Brouillet JP, Sarda P, Maudelonde T, Pujol P
Cancer Genet Cytogenet. 2004
PubMed ID: 15571801
-93G-->A polymorphism of hMLH1 and risk of primary lung cancer.
Park SH, Lee GY, Jeon HS, Lee SJ, Kim KM, Jang SS, Kim CH, Lee WK, Kam S, Park RW, Kim IS, Jung TH, Park JY
Int J Cancer. 2004
PubMed ID: 15382050
Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.
Fearnhead NS, Wilding JL, Winney B, Tonks S, Bartlett S, Bicknell DC, Tomlinson IP, Mortensen NJ, Bodmer WF
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15520370
[Study on the relationship between genetic polymorphism Val384Asp in hMLH1 gene and the risk of four different carcinomas.]
Zhang XM, Li JT, Zhu M, Wu XL, Gao P, Zhou P, Wang YP
Zhonghua Liu Xing Bing Xue Za Zhi. 2004
PubMed ID: 15769334
Susceptibility to refractory ulcerative colitis is associated with polymorphism in the hMLH1 mismatch repair gene.
Bagnoli S, Putignano AL, Melean G, Baglioni S, Sestini R, Milla M, d'Albasio G, Genuardi M, Pacini F, Trallori G, Papi L
Inflamm Bowel Dis. 2004
PubMed ID: 15626886
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Mismatch repair gene expression and genetic instability in testicular germ cell tumor.
Velasco A, Riquelme E, Schultz M, Wistuba II, Villarroel L, Pizarro J, Berlin A, Ittmann M, Koh MS, Leach FS
Cancer Biol Ther. 2004
PubMed ID: 15467433
Ten novel MSH2 and MLH1 germline mutations in families with HNPCC.
Krüger S, Bier A, Plaschke J, Höhl R, Aust DE, Kreuz FR, Pistorius SR, Saeger HD, Rothhammer V, Al-Taie O, Schackert HK
Hum Mutat. 2004
PubMed ID: 15365996
Germline mutations in MLH1, MSH2 and MSH6 in Korean hereditary non-polyposis colorectal cancer families.
Shin YK, Heo SC, Shin JH, Hong SH, Ku JL, Yoo BC, Kim IJ, Park JG
Hum Mutat. 2004
PubMed ID: 15365995
Promoter methylation and expression of DNA repair genes hMLH1 and MGMT in acute myeloid leukemia.
Lenz G, Hutter G, Hiddemann W, Dreyling M
Ann Hematol. 2004
PubMed ID: 15309527
Clinical features and mismatch repair gene mutation screening in Chinese patients with hereditary nonpolyposis colorectal carcinoma.
Liu SR, Zhao B, Wang ZJ, Wan YL, Huang YT
World J Gastroenterol. 2004
PubMed ID: 15309712
The novel germline mutation of the hMLH1 gene in a case of suspected hereditary non-polyposis colorectal cancer (HNPCC) in a patient with no family history of cancer.
Tomita N, Fukunaga M, Okamura S, Nakata K, Ohzato H, Tamura S, Sugimoto K, Aihara T, Miki H, Takatsuka Y, Matsuura N, Ishikawa H, Iwanaga T, Fukayama N, Sugano K
Jpn J Clin Oncol. 2004
PubMed ID: 15466831
Colorectal cancer prevention.
Kauh J, Umbreit J
Curr Probl Cancer. 2004
PubMed ID: 15375803
BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing.
Domingo E, Laiho P, Ollikainen M, Pinto M, Wang L, French AJ, Westra J, Frebourg T, Espín E, Armengol M, Hamelin R, Yamamoto H, Hofstra RM, Seruca R, Lindblom A, Peltomäki P, Thibodeau SN, Aaltonen LA, Schwartz S
J Med Genet. 2004
PubMed ID: 15342696
RNA analysis reveals splicing mutations and loss of expression defects in MLH1 and BRCA1.
Sharp A, Pichert G, Lucassen A, Eccles D
Hum Mutat. 2004
PubMed ID: 15300854
Mononucleotide markers of microsatellite instability in carcinomas of the urinary bladder.
Saetta AA, Goudopoulou A, Korkolopoulou P, Voutsinas G, Thomas-Tsagli E, Michalopoulos NV, Patsouris E
Eur J Surg Oncol. 2004
PubMed ID: 15296997
NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression.
Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM
Science. 2004
PubMed ID: 15326356
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.
Fang Y, Tsao CC, Goodman BK, Furumai R, Tirado CA, Abraham RT, Wang XF
EMBO J. 2004
PubMed ID: 15282542
Psychologic distress after disclosure of genetic test results regarding hereditary nonpolyposis colorectal carcinoma.
Murakami Y, Okamura H, Sugano K, Yoshida T, Kazuma K, Akechi T, Uchitomi Y
Cancer. 2004
PubMed ID: 15241839
The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients.
Gifford G, Paul J, Vasey PA, Kaye SB, Brown R
Clin Cancer Res. 2004
PubMed ID: 15240532
ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage.
Luo Y, Lin FT, Lin WC
Mol Cell Biol. 2004
PubMed ID: 15226443
The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer.
Lipkin SM, Rozek LS, Rennert G, Yang W, Chen PC, Hacia J, Hunt N, Shin B, Fodor S, Kokoris M, Greenson JK, Fearon E, Lynch H, Collins F, Gruber SB
Nat Genet. 2004
PubMed ID: 15184898
HNPCC mutation MLH1 P648S makes the functional protein unstable, and homozygosity predisposes to mild neurofibromatosis type 1.
Raevaara TE, Gerdes AM, Lönnqvist KE, Tybjaerg-Hansen A, Abdel-Rahman WM, Kariola R, Peltomäki P, Nyström-Lahti M
Genes Chromosomes Cancer. 2004
PubMed ID: 15139004
Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function.
Haigis KM, Hoff PD, White A, Shoemaker AR, Halberg RB, Dove WF
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15210940
Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis.
Chen F, Arseven OK, Cryns VL
J Biol Chem. 2004
PubMed ID: 15087450
Repression of MLH1 and MGMT genes in colon mucosa adjacent to implanted cancer in athymic mouse.
Kuniyasu H, Sasaki T, Sasahira T, Chihara Y, Ohmori H
J Exp Clin Cancer Res. 2004
PubMed ID: 15354418
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW
Nat Biotechnol. 2004
PubMed ID: 15146197
Modulation of error-prone double-strand break repair in mammalian chromosomes by DNA mismatch repair protein Mlh1.
Bannister LA, Waldman BC, Waldman AS
DNA Repair (Amst). 2004
PubMed ID: 15084308
[Clinical features and hMSH2/hMLH1 germline mutation screening of Chinese hereditary nonpolyposis colorectal cancer patients]
Liu SR, Wang ZJ, Zhao B, Wan YL, Huang YT
Zhonghua Yi Xue Za Zhi. 2004
PubMed ID: 15200905
Microsatellite instability and hMLH1 and hMSH2 gene expression in Taiwanese hereditary nonpolyposis colorectal cancer.
Wei SC, Shun CT, Tsai-Wu JJ, Wu CH, Sheu JC, Wang CY, Wong JM
J Formos Med Assoc. 2004
PubMed ID: 15216397
High-throughput association testing on DNA pools to identify genetic variants that confer susceptibility to acute myeloid leukemia.
Rollinson S, Allan JM, Law GR, Roddam PL, Smith MT, Skibola C, Smith AG, Forrest MS, Sibley K, Higuchi R, Germer S, Morgan GJ
Cancer Epidemiol Biomarkers Prev. 2004
PubMed ID: 15159312
Germline epimutation of MLH1 in individuals with multiple cancers.
Suter CM, Martin DI, Ward RL
Nat Genet. 2004
PubMed ID: 15064764
Impairment of MLH1 and CDKN2A in oncogenesis of laryngeal cancer.
Sasiadek MM, Stembalska-Kozlowska A, Smigiel R, Ramsey D, Kayademir T, Blin N
Br J Cancer. 2004
PubMed ID: 15083191
Mutation analysis of the MLH1, MSH2 and MSH6 genes in patients with double primary cancers of the colorectum and the endometrium: a population-based study in northern Sweden.
Cederquist K, Emanuelsson M, Göransson I, Holinski-Feder E, Müller-Koch Y, Golovleva I, Grönberg H
Int J Cancer. 2004
PubMed ID: 14961575
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Altered expression and new mutations in DNA mismatch repair genes MLH1 and MSH2 in melanoma brain metastases.
Korabiowska M, König F, Verheggen R, Schlott T, Cordon-Cardo C, Romeike B, Brinck U
Anticancer Res. 2004
PubMed ID: 15161053
A founder MLH1 mutation in families from the districts of Modena and Reggio-Emilia in northern Italy with hereditary non-polyposis colorectal cancer associated with protein elongation and instability.
Caluseriu O, Di Gregorio C, Lucci-Cordisco E, Santarosa M, Trojan J, Brieger A, Benatti P, Pedroni M, Colibazzi T, Bellacosa A, Neri G, Ponz de Leon M, Viel A, Genuardi M
J Med Genet. 2004
PubMed ID: 14985405
Correlation among loss of heterozygosity, promoter methylation and protein expression of MLH1 in larynx cancer.
Smigiel R, Stembalska-Kozlowska A, Mirghomizadeh F, Krecicki T, Zatonski T, Ramsey D, Horobiowska M, Jagielski J, Blin N, Sasiadek M
Oncol Rep. 2004
PubMed ID: 14767526
Correlation between patterns of DNA mismatch repair hmlh1 and hmsh2 protein expression and progression of dysplasia in intraductal papillary mucinous neoplasms of the pancreas.
Handra-Luca A, Couvelard A, Degott C, Fléjou JF
Virchows Arch. 2004
PubMed ID: 14760534
Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA.
Nielsen FC, Jäger AC, Lützen A, Bundgaard JR, Rasmussen LJ
Oncogene. 2004
PubMed ID: 14676842
[Clinical analysis and molecular genetic study of hereditary nonpolyposis colorectal cancer kindreds]
Luo DC, Cai Q, Sun MH, Ni YZ, Tao CW, Chen ZJ, Shi DR
Zhonghua Wai Ke Za Zhi. 2004
PubMed ID: 15062061
Acceptance of and attitude toward genetic testing for hereditary nonpolyposis colorectal cancer: a comparison of participants and nonparticipants in genetic counseling.
Keller M, Jost R, Kadmon M, Wüllenweber HP, Haunstetter CM, Willeke F, Jung C, Gebert J, Sutter C, Herfarth C, Büchler MW
Dis Colon Rectum. 2004
PubMed ID: 15043284
Loss of MSH3 protein expression is frequent in MLH1-deficient colorectal cancer and is associated with disease progression.
Plaschke J, Krüger S, Jeske B, Theissig F, Kreuz FR, Pistorius S, Saeger HD, Iaccarino I, Marra G, Schackert HK
Cancer Res. 2004
PubMed ID: 14871813
Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.
Kuramochi-Miyagawa S, Kimura T, Ijiri TW, Isobe T, Asada N, Fujita Y, Ikawa M, Iwai N, Okabe M, Deng W, Lin H, Matsuda Y, Nakano T
Development. 2004
PubMed ID: 14736746
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice.
Bardwell PD, Woo CJ, Wei K, Li Z, Martin A, Sack SZ, Parris T, Edelmann W, Scharff MD
Nat Immunol. 2004
PubMed ID: 14716311
Genetic detection of Chinese hereditary nonpolyposis colorectal cancer.
Cui L, Jin HY, Cheng HY, Yan YD, Meng RG, Yu DH
World J Gastroenterol. 2004
PubMed ID: 14716824
Analysis of candidate genes for prostate cancer.
Burmester JK, Suarez BK, Lin JH, Jin CH, Miller RD, Zhang KQ, Salzman SA, Reding DJ, Catalona WJ
Hum Hered. 2004
PubMed ID: 15583422
Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain.
Ellison AR, Lofing J, Bitter GA
Nucleic Acids Res. 2004
PubMed ID: 15475387
Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination.
Kolas NK, Cohen PE
Cytogenet Genome Res. 2004
PubMed ID: 15467367
Genotyping possible polymorphic variants of human mismatch repair genes in healthy Korean individuals and sporadic colorectal cancer patients.
Kim JC, Roh SA, Koo KH, Ka IH, Kim HC, Yu CS, Lee KH, Kim JS, Lee HI, Bodmer WF
Fam Cancer. 2004
PubMed ID: 15340264
Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer.
Arnold CN, Goel A, Compton C, Marcus V, Niedzwiecki D, Dowell JM, Wasserman L, Inoue T, Mayer RJ, Bertagnolli MM, Boland CR
Cancer Biol Ther. 2004
PubMed ID: 14726676
Microsatellite instability and expression of hMLH1 and hMSH2 proteins in ovarian endometrioid cancer.
Liu J, Albarracin CT, Chang KH, Thompson-Lanza JA, Zheng W, Gershenson DM, Broaddus R, Luthra R
Mod Pathol. 2004
PubMed ID: 14631366
hMLH1 and hMSH2 gene mutations are present in radial growth-phase cutaneous malignant melanoma cell lines and can be induced further by ultraviolet-B irradiation.
Hussein MR, Wood GS
Exp Dermatol. 2003
PubMed ID: 14714570
Toward new strategies to select young endometrial cancer patients for mismatch repair gene mutation analysis.
Berends MJ, Wu Y, Sijmons RH, van der Sluis T, Ek WB, Ligtenberg MJ, Arts NJ, ten Hoor KA, Kleibeuker JH, de Vries EG, Mourits MJ, Hollema H, Buys CH, Hofstra RM, van der Zee AG
J Clin Oncol. 2003
PubMed ID: 14645426
Genomic deletions in MSH2 or MLH1 are a frequent cause of hereditary non-polyposis colorectal cancer: identification of novel and recurrent deletions by MLPA.
Taylor CF, Charlton RS, Burn J, Sheridan E, Taylor GR
Hum Mutat. 2003
PubMed ID: 14635101
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Missense mutations in hMLH1 and hMSH2 are associated with exonic splicing enhancers.
Gorlov IP, Gorlova OY, Frazier ML, Amos CI
Am J Hum Genet. 2003
PubMed ID: 14526391
MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine.
Sansom OJ, Zabkiewicz J, Bishop SM, Guy J, Bird A, Clarke AR
Oncogene. 2003
PubMed ID: 14562041
Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis.
Takagi Y, Takahashi M, Sanada M, Ito R, Yamaizumi M, Sekiguchi M
DNA Repair (Amst). 2003
PubMed ID: 13679151
Microsatellite instability is associated with hypermethylation of the hMLH1 gene and reduced gene expression in mycosis fungoides.
Scarisbrick JJ, Mitchell TJ, Calonje E, Orchard G, Russell-Jones R, Whittaker SJ
J Invest Dermatol. 2003
PubMed ID: 14632210
Reduced MLH1 expression after chemotherapy is an indicator for poor prognosis in esophageal cancers.
Kishi K, Doki Y, Yano M, Yasuda T, Fujiwara Y, Takiguchi S, Kim S, Higuchi I, Monden M
Clin Cancer Res. 2003
PubMed ID: 14555508
Gynecologic screening in hereditary nonpolyposis colorectal cancer.
Rijcken FE, Mourits MJ, Kleibeuker JH, Hollema H, van der Zee AG
Gynecol Oncol. 2003
PubMed ID: 14529665
Role of DNA mismatch repair genetic polymorphisms in the risk of childhood acute lymphoblastic leukaemia.
Mathonnet G, Krajinovic M, Labuda D, Sinnett D
Br J Haematol. 2003
PubMed ID: 14510941
High-resolution methylation analysis of the hMLH1 promoter in sporadic endometrial and colorectal carcinomas.
Strazzullo M, Cossu A, Baldinu P, Colombino M, Satta MP, Tanda F, De Bonis ML, Cerase A, D'Urso M, D'Esposito M, Palmieri G
Cancer. 2003
PubMed ID: 14508843
Microsatellite instability and mutation analysis among southern Italian patients with colorectal carcinoma: detection of different alterations accounting for MLH1 and MSH2 inactivation in familial cases.
Colombino M, Cossu A, Arba A, Manca A, Curci A, Avallone A, Comella G, Botti G, Scintu F, Amoruso M, D'Abbicco D, d'Agnessa MR, Spanu A, Tanda F, Palmieri G
Ann Oncol. 2003
PubMed ID: 14504054
Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo.
Sansom OJ, Bishop SM, Court H, Dudley S, Liskay RM, Clarke AR
DNA Repair (Amst). 2003
PubMed ID: 12967659
Possible association between tumor-suppressor gene mutations and hMSH2/hMLH1 inactivation in alveolar soft part sarcoma.
Saito T, Oda Y, Kawaguchi K, Takahira T, Yamamoto H, Sakamoto A, Tamiya S, Iwamoto Y, Tsuneyoshi M
Hum Pathol. 2003
PubMed ID: 14562278
Identification and characterization of genomic rearrangements of MSH2 and MLH1 in Lynch syndrome (HNPCC) by novel techniques.
Nakagawa H, Hampel H, de la Chapelle A
Hum Mutat. 2003
PubMed ID: 12938096
Electro-oculographic and electroretinographic studies in HNPCC gene mutation carriers.
Lubiński W, Kurzawski G, Suchy J, Szych Z, Penkala K, Palacz O, Scott RJ, Lubiński J
Ophthalmic Res. 2003
PubMed ID: 12920342
Low mutation rate of hMSH2 and hMLH1 in Taiwanese hereditary non-polyposis colorectal cancer.
Wei SC, Yu CY, Tsai-Wu JJ, Su YN, Sheu JC, Wu CH, Wang CY, Wong JM
Clin Genet. 2003
PubMed ID: 12919140
Germline hMLH1 promoter mutation in a Newfoundland HNPCC kindred.
Green RC, Green AG, Simms M, Pater A, Robb JD, Green JS
Clin Genet. 2003
PubMed ID: 12919137
Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia.
Wong JC, Alon N, Mckerlie C, Huang JR, Meyn MS, Buchwald M
Hum Mol Genet. 2003
PubMed ID: 12913077
[Mutation analysis on MSH2 and MLH1 genes in patients of colorectal cancer at early age]
Wang YP, Zhang JN, Li JT, Zhou JN, Zhang XM, Zhu M
Zhonghua Yi Xue Za Zhi. 2003
PubMed ID: 12930688
Molecular pathology of atypical polypoid adenomyoma of the uterus.
Ota S, Catasus L, Matias-Guiu X, Bussaglia E, Lagarda H, Pons C, Muñoz J, Kamura T, Prat J
Hum Pathol. 2003
PubMed ID: 14506639
Genetics supersedes epigenetics in colon cancer phenotype.
Yamashita K, Dai T, Dai Y, Yamamoto F, Perucho M
Cancer Cell. 2003
PubMed ID: 12957287
Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates.
Yanamadala S, Ljungman M
Mol Cancer Res. 2003
PubMed ID: 12939400
Mlh1 deficiency accelerates myeloid leukemogenesis in neurofibromatosis 1 (Nf1) heterozygous mice.
Gutmann DH, Winkeler E, Kabbarah O, Hedrick N, Dudley S, Goodfellow PJ, Liskay RM
Oncogene. 2003
PubMed ID: 12881715
Differential expression of hMLH1 and hMSH2 is related to bladder cancer grade, stage and prognosis but not microsatellite instability.
Catto JW, Xinarianos G, Burton JL, Meuth M, Hamdy FC
Int J Cancer. 2003
PubMed ID: 12712438
A yeast two-hybrid assay provides a simple way to evaluate the vast majority of hMLH1 germ-line mutations.
Kondo E, Suzuki H, Horii A, Fukushige S
Cancer Res. 2003
PubMed ID: 12810663
N-terminus of hMLH1 confers interaction of hMutLalpha and hMutLbeta with hMutSalpha.
Plotz G, Raedle J, Brieger A, Trojan J, Zeuzem S
Nucleic Acids Res. 2003
PubMed ID: 12799449
Characterization of mutator pathway in younger-age-onset colorectal adenocarcinomas.
Roh SA, Kim HC, Kim JS, Kim JC
J Korean Med Sci. 2003
PubMed ID: 12808326
Cell type-dependent regulation of hMLH1 promoter activity is influenced by the presence of multiple redundant elements.
Warnick CT, Dabbas B, Ilstrup SJ, Ford CD, Strait KA
Mol Cancer Res. 2003
PubMed ID: 12805408
Biallelic somatic inactivation of the mismatch repair gene MLH1 in a primary skin melanoma.
Castiglia D, Pagani E, Alvino E, Vernole P, Marra G, Cannavò E, Jiricny J, Zambruno G, D'Atri S
Genes Chromosomes Cancer. 2003
PubMed ID: 12696065
Mlh1 can function in antibody class switch recombination independently of Msh2.
Schrader CE, Vardo J, Stavnezer J
J Exp Med. 2003
PubMed ID: 12743174
Methylation-induced G(2)/M arrest requires a full complement of the mismatch repair protein hMLH1.
Cejka P, Stojic L, Mojas N, Russell AM, Heinimann K, Cannavó E, di Pietro M, Marra G, Jiricny J
EMBO J. 2003
PubMed ID: 12727890
A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.
Meetei AR, Sechi S, Wallisch M, Yang D, Young MK, Joenje H, Hoatlin ME, Wang W
Mol Cell Biol. 2003
PubMed ID: 12724401
Microsatellite instability in esophageal squamous cell carcinoma is not associated with hMLH1 promoter hypermethylation.
Hayashi M, Tamura G, Jin Z, Kato I, Sato M, Shibuya Y, Yang S, Motoyama T
Pathol Int. 2003
PubMed ID: 12713560
Dimerization of MLH1 and PMS2 limits nuclear localization of MutLalpha.
Wu X, Platt JL, Cascalho M
Mol Cell Biol. 2003
PubMed ID: 12697830
Global DNA methylation in relation to hMLH1 and hMSH2 protein immunoreactivity in sporadic human endometrial carcinomas.
Miturski R, Postawski K, Semczuk A, Bogusiewicz M, Baranowski W, Jakowicki JA, Keith G
Int J Mol Med. 2003
PubMed ID: 12684691
Alterations in PMS2, MSH2 and MLH1 expression in human prostate cancer.
Chen Y, Wang J, Fraig MM, Henderson K, Bissada NK, Watson DK, Schweinfest CW
Int J Oncol. 2003
PubMed ID: 12684669
Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene.
Wagner A, Barrows A, Wijnen JT, van der Klift H, Franken PF, Verkuijlen P, Nakagawa H, Geugien M, Jaghmohan-Changur S, Breukel C, Meijers-Heijboer H, Morreau H, van Puijenbroek M, Burn J, Coronel S, Kinarski Y, Okimoto R, Watson P, Lynch JF, de la Chapelle A, Lynch HT, Fodde R
Am J Hum Genet. 2003
PubMed ID: 12658575
Frequent hypermethylation of MLH1 promoter in normal endometrium of patients with endometrial cancers.
Kanaya T, Kyo S, Maida Y, Yatabe N, Tanaka M, Nakamura M, Inoue M
Oncogene. 2003
PubMed ID: 12700670
Mutation and methylation of hMLH1 in gastric carcinomas with microsatellite instability.
Fang DC, Wang RQ, Yang SM, Yang JM, Liu HF, Peng GY, Xiao TL, Luo YH
World J Gastroenterol. 2003
PubMed ID: 12679904
Three new mutations in hereditary nonpolyposis colorectal cancer (Lynch syndrome II) in Uruguay.
Sarroca C, Peltomäki P, Alfano N, Tedesco G, Della Valle A, Dominguez A, Lynch HT
Cancer Genet Cytogenet. 2003
PubMed ID: 12660027
Genetic analysis of familial colorectal cancer in Israeli Arabs.
Chen-Shtoyerman R, Theodor L, Harmati E, Friedman E, Dacka S, Kopelman Y, Sternberg A, Zarivach R, Bar-Meir S, Fireman Z
Hum Mutat. 2003
PubMed ID: 12655564
Identification of six novel MSH2 and MLH1 germline mutations in HNPCC.
Krüger S, Plaschke J, Jeske B, Görgens H, Pistorius SR, Bier A, Kreuz FR, Theissig F, Aust DE, Saeger HD, Schackert HK
Hum Mutat. 2003
PubMed ID: 12655562
Human mismatch-repair protein MutL homologue 1 (MLH1) interacts with Escherichia coli MutL and MutS in vivo and in vitro: a simple genetic system to assay MLH1 function.
Quaresima B, Alifano P, Tassone P, Avvedimento EV, Costanzo FS, Venuta S
Biochem J. 2003
PubMed ID: 12513688
Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestine.
Planck M, Ericson K, Piotrowska Z, Halvarsson B, Rambech E, Nilbert M
Cancer. 2003
PubMed ID: 12627520
Frequency of loss of hMLH1 expression in colorectal carcinoma increases with advancing age.
Kakar S, Burgart LJ, Thibodeau SN, Rabe KG, Petersen GM, Goldberg RM, Lindor NM
Cancer. 2003
PubMed ID: 12627505
Genetic counseling and testing in families with hereditary nonpolyposis colorectal cancer.
Hadley DW, Jenkins J, Dimond E, Nakahara K, Grogan L, Liewehr DJ, Steinberg SM, Kirsch I
Arch Intern Med. 2003
PubMed ID: 12622604
Pathology of mouse models of intestinal cancer: consensus report and recommendations.
Boivin GP, Washington K, Yang K, Ward JM, Pretlow TP, Russell R, Besselsen DG, Godfrey VL, Doetschman T, Dove WF, Pitot HC, Halberg RB, Itzkowitz SH, Groden J, Coffey RJ
Gastroenterology. 2003
PubMed ID: 12612914
Promoter hypermethylation and inactivation of hMLH1, a DNA mismatch repair gene, in head and neck squamous cell carcinoma.
Liu K, Zuo C, Luo QK, Suen JY, Hanna E, Fan CY
Diagn Mol Pathol. 2003
PubMed ID: 12605036
CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection.
Matsukura S, Soejima H, Nakagawachi T, Yakushiji H, Ogawa A, Fukuhara M, Miyazaki K, Nakabeppu Y, Sekiguchi M, Mukai T
Br J Cancer. 2003
PubMed ID: 12592365
Hereditary nonpolyposis colorectal cancer: frequent occurrence of large genomic deletions in MSH2 and MLH1 genes.
Wang Y, Friedl W, Lamberti C, Jungck M, Mathiak M, Pagenstecher C, Propping P, Mangold E
Int J Cancer. 2003
PubMed ID: 12494471
Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX.
Mac Partlin M, Homer E, Robinson H, McCormick CJ, Crouch DH, Durant ST, Matheson EC, Hall AG, Gillespie DA, Brown R
Oncogene. 2003
PubMed ID: 12584560
Microsatellite instability and hMLH1 promoter hypermethylation in Richter's transformation of chronic lymphocytic leukemia.
Fülöp Z, Csernus B, Tímár B, Szepesi A, Matolcsy A
Leukemia. 2003
PubMed ID: 12592341
hMLH1 and hMSH2 somatic inactivation mechanisms in sporadic colorectal cancer patients.
Kámory E, Kolacsek O, Ottó S, Csuka O
Pathol Oncol Res. 2003
PubMed ID: 14688830
Variable continental distribution of polymorphisms in the coding regions of DNA-repair genes.
Mathonnet G, Labuda D, Meloche C, Wambach T, Krajinovic M, Sinnett D
J Hum Genet. 2003
PubMed ID: 14625810
Does the occurrence of certain rare cancers indicate an inherited cancer susceptibility?
Levene S, Scott G, Price P, Sanderson J, Evans H, Taylor C, Bass S, Lewis C, Hodgson S
Fam Cancer. 2003
PubMed ID: 14574163
Expression of the DNA mismatch repair proteins (hMLH1 and hMSH2) in infiltrating pancreatic cancer and its relation to some phenotypic features.
Tomaszewska R, Okoń K, Stachura J
Pol J Pathol. 2003
PubMed ID: 12817878
Analyzing tumor suppressor activities in the murine small intestine.
Clarke AR, Sansom OJ
Oncol Res. 2003
PubMed ID: 12725522
Methylation of the hMLH1 promoter and its association with microsatellite instability in acute myeloid leukemia.
Seedhouse CH, Das-Gupta EP, Russell NH
Leukemia. 2003
PubMed ID: 12529664
Silencing-specific methylation and single nucleotide polymorphism of hMLH1 promoter in gastric carcinomas.
Deng DJ, Zhou J, Zhu BD, Ji JF, Harper JC, Powell SM
World J Gastroenterol. 2003
PubMed ID: 12508345
Mutation analysis of K-ras and beta-catenin genes related to O6-methylguanin-DNA methyltransferase and mismatch repair protein status in human gallbladder carcinoma.
Kohya N, Kitajima Y, Kitahara K, Miyazaki K
Int J Mol Med. 2003
PubMed ID: 12469220
Methylation profile of the MLH1 promoter region and their relationship to colorectal carcinogenesis.
Miyakura Y, Sugano K, Konishi F, Fukayama N, Igarashi S, Kotake K, Matsui T, Koyama Y, Maekawa M, Nagai H
Genes Chromosomes Cancer. 2003
PubMed ID: 12461746
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Essential role of citron kinase in cytokinesis of spermatogenic precursors.
Cunto FD, Imarisio S, Camera P, Boitani C, Altruda F, Silengo L
J Cell Sci. 2002
PubMed ID: 12432070
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Mismatch repair genes hMLH1 and hMSH2 and colorectal cancer: a HuGE review.
Mitchell RJ, Farrington SM, Dunlop MG, Campbell H
Am J Epidemiol. 2002
PubMed ID: 12419761
Diet, cancer and aging in DNA mismatch repair deficient mice.
Tsao JL, Dudley S, Kwok B, Nickel AE, Laird PW, Siegmund KD, Liskay RM, Shibata D
Carcinogenesis. 2002
PubMed ID: 12419828
Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome.
Sun X, Zheng L, Shen B
Cancer Res. 2002
PubMed ID: 12414623
Different molecular mechanisms underlie genomic deletions in the MLH1 Gene.
Viel A, Petronzelli F, Della Puppa L, Lucci-Cordisco E, Fornasarig M, Pucciarelli S, Rovella V, Quaia M, Ponz de Leon M, Boiocchi M, Genuardi M
Hum Mutat. 2002
PubMed ID: 12402334
Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas.
Shibata DM, Sato F, Mori Y, Perry K, Yin J, Wang S, Xu Y, Olaru A, Selaru F, Spring K, Young J, Abraham JM, Meltzer SJ
Cancer Res. 2002
PubMed ID: 12384516
Genomic deletions of MSH2 and MLH1 in colorectal cancer families detected by a novel mutation detection approach.
Gille JJ, Hogervorst FB, Pals G, Wijnen JT, van Schooten RJ, Dommering CJ, Meijer GA, Craanen ME, Nederlof PM, de Jong D, McElgunn CJ, Schouten JP, Menko FH
Br J Cancer. 2002
PubMed ID: 12373605
Germline MSH2 and MLH1 mutational spectrum in HNPCC families from Poland and the Baltic States.
Kurzawski G, Suchy J, Kładny J, Safranow K, Jakubowska A, Elsakov P, Kucinskas V, Gardovski J, Irmejs A, Sibul H, Huzarski T, Byrski T, Debniak T, Cybulski C, Gronwald J, Oszurek O, Clark J, Góźdź S, Niepsuj S, Słomski R, Pławski A, Łacka-Wojciechowska A, Rozmiarek A, Fiszer-Maliszewska Ł, Bebenek M, Sorokin D, Stawicka M, Godlewski D, Richter P, Brozek I, Wysocka B, Jawień A, Banaszkiewicz Z, Kowalczyk J, Czudowska D, Goretzki PE, Moeslein G, Lubiński J
J Med Genet. 2002
PubMed ID: 12362047
Renal cell carcinoma: taking care of business.
Morin PJ
Cancer Biol Ther. 2002
PubMed ID: 12496484
Mismatch repair gene mutations in renal cell carcinoma.
Leach FS, Koh M, Sharma K, McWilliams G, Talifero-Smith L, Codd A, Olea R, Elbahloul O
Cancer Biol Ther. 2002
PubMed ID: 12496483
Meiotic prophase abnormalities and metaphase cell death in MLH1-deficient mouse spermatocytes: insights into regulation of spermatogenic progress.
Eaker S, Cobb J, Pyle A, Handel MA
Dev Biol. 2002
PubMed ID: 12217320
Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status.
Magrini R, Bhonde MR, Hanski ML, Notter M, Scherübl H, Boland CR, Zeitz M, Hanski C
Int J Cancer. 2002
PubMed ID: 12209584
Densely methylated MLH1 promoter correlates with decreased mRNA expression in sporadic colorectal cancers.
Furukawa T, Konishi F, Masubuchi S, Shitoh K, Nagai H, Tsukamoto T
Genes Chromosomes Cancer. 2002
PubMed ID: 12203784
Genetic and epigenetic modification of mismatch repair genes hMSH2 and hMLH1 in sporadic breast cancer with microsatellite instability.
Murata H, Khattar NH, Kang Y, Gu L, Li GM
Oncogene. 2002
PubMed ID: 12173039
Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma.
Andachi H, Yashima K, Koda M, Kawaguchi K, Kitamura A, Hosoda A, Kishimoto Y, Shiota G, Ito H, Makino M, Kaibara N, Kawasaki H, Murawaki Y
Br J Cancer. 2002
PubMed ID: 12177781
Impact of microsatellite testing and mismatch repair protein expression on the clinical interpretation of genetic testing in hereditary non-polyposis colorectal cancer.
Ward R, Meldrum C, Williams R, Mokany E, Scott R, Turner J, Hawkins N, Burgess B, Groombridge C, Spigelman A
J Cancer Res Clin Oncol. 2002
PubMed ID: 12200596
Meiotic arrest and aneuploidy in MLH3-deficient mice.
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Nat Genet. 2002
PubMed ID: 12091911
hMLH1 and hMSH2 gene mutation in Brazilian families with suspected hereditary nonpolyposis colorectal cancer.
Rossi BM, Lopes A, Oliveira Ferreira F, Nakagawa WT, Napoli Ferreira CC, Casali Da Rocha JC, Simpson CC, Simpson AJ
Ann Surg Oncol. 2002
PubMed ID: 12095971
Microsatellite instability and mutation analysis of candidate genes in unselected sardinian patients with endometrial carcinoma.
Baldinu P, Cossu A, Manca A, Satta MP, Pisano M, Casula M, Dessole S, Pintus A, Tanda F, Palmieri G
Cancer. 2002
PubMed ID: 12115348
Mutations within the hMLH1 and hPMS2 subunits of the human MutLalpha mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSalpha.
Räschle M, Dufner P, Marra G, Jiricny J
J Biol Chem. 2002
PubMed ID: 11948175
Contribution of human mlh1 and pms2 ATPase activities to DNA mismatch repair.
Tomer G, Buermeyer AB, Nguyen MM, Liskay RM
J Biol Chem. 2002
PubMed ID: 11897781
MSI in endometrial carcinoma: absence of MLH1 promoter methylation is associated with increased familial risk for cancers.
Whelan AJ, Babb S, Mutch DG, Rader J, Herzog TJ, Todd C, Ivanovich JL, Goodfellow PJ
Int J Cancer. 2002
PubMed ID: 12115503
Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage.
Catani MV, Costanzo A, Savini I, Levrero M, de Laurenzi V, Wang JY, Melino G, Avigliano L
Biochem J. 2002
PubMed ID: 12023887
Genomic instability in mice lacking histone H2AX.
Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E, Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M, Camerini-Otero RD, Tessarollo L, Livak F, Manova K, Bonner WM, Nussenzweig MC, Nussenzweig A
Science. 2002
PubMed ID: 11934988
Association of Crohn's disease and ulcerative colitis with haplotypes of the MLH1 gene in Italian inflammatory bowel disease patients.
Annese V, Piepoli A, Andriulli A, Latiano A, Napolitano G, Li HH, Forabosco P, Devoto M
J Med Genet. 2002
PubMed ID: 12011151
DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair.
Trinh BN, Long TI, Nickel AE, Shibata D, Laird PW
Mol Cell Biol. 2002
PubMed ID: 11940649
Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain.
Caldes T, Godino J, de la Hoya M, Garcia Carbonero I, Perez Segura P, Eng C, Benito M, Diaz-Rubio E
Int J Cancer. 2002
PubMed ID: 11920650
DNA mismatch repair deficiency accelerates endometrial tumorigenesis in Pten heterozygous mice.
Wang H, Douglas W, Lia M, Edelmann W, Kucherlapati R, Podsypanina K, Parsons R, Ellenson LH
Am J Pathol. 2002
PubMed ID: 11943731
Hereditary nonpolyposis colorectal cancer in young colorectal cancer patients: high-risk clinic versus population-based registry.
Terdiman JP, Levin TR, Allen BA, Gum JR, Fishbach A, Conrad PG, Miller GA, Weinberg V, Bachman R, Bergoffen J, Stembridge A, Toribara NW, Sleisenger MH, Kim YS
Gastroenterology. 2002
PubMed ID: 11910346
Mutation analysis of MLH1 and MSH2 genes performed by denaturing high-performance liquid chromatography.
Kurzawski G, Safranow K, Suchy J, Chlubek D, Scott RJ, Lubiński J
J Biochem Biophys Methods. 2002
PubMed ID: 11879922
Frequent LOH at hMLH1, a highly variable SNP in hMSH3, and negligible coding instability in ovarian cancer.
Arzimanoglou II, Hansen LL, Chong D, Li Z, Psaroudi MC, Dimitrakakis C, Jacovina AT, Shevchuk M, Reid L, Hajjar KA, Vassilaros S, Michalas S, Gilbert F, Chervenak FA, Barber HR
Anticancer Res. 2002
PubMed ID: 12014680
Comprehensive analysis of promoter methylation and altered expression of hMLH1 in gastric cancer cell lines with microsatellite instability.
Kang YH, Bae SI, Kim WH
J Cancer Res Clin Oncol. 2002
PubMed ID: 11935297
Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia.
Krajinovic M, Labuda D, Mathonnet G, Labuda M, Moghrabi A, Champagne J, Sinnett D
Clin Cancer Res. 2002
PubMed ID: 11895912
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.
Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J
Genes Dev. 2002
PubMed ID: 11877377
Mutations of hMLH1 and hMSH2 in patients with suspected hereditary nonpolyposis colorectal cancer: correlation with microsatellite instability and abnormalities of mismatch repair protein expression.
Scartozzi M, Bianchi F, Rosati S, Galizia E, Antolini A, Loretelli C, Piga A, Bearzi I, Cellerino R, Porfiri E
J Clin Oncol. 2002
PubMed ID: 11870161
A modified multiplex PCR assay for detection of large deletions in MSH2 and MLH1.
Wang Y, Friedl W, Sengteller M, Jungck M, Filges I, Propping P, Mangold E
Hum Mutat. 2002
PubMed ID: 11857745
Pathogenicity of missense and splice site mutations in hMSH2 and hMLH1 mismatch repair genes: implications for genetic testing.
Cravo M, Afonso AJ, Lage P, Albuquerque C, Maia L, Lacerda C, Fidalgo P, Chaves P, Cruz C, Nobre-Leitão C
Gut. 2002
PubMed ID: 11839723
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions.
Schrader CE, Vardo J, Stavnezer J
J Exp Med. 2002
PubMed ID: 11828012
Mismatch repair gene expression in malignant lymphoproliferative disorders of B-cell origin.
Kotoula V, Hytiroglou P, Kaloutsi V, Barbanis S, Kouidou S, Papadimitriou CS
Leuk Lymphoma. 2002
PubMed ID: 11999575
hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.
Plotz G, Raedle J, Brieger A, Trojan J, Zeuzem S
Nucleic Acids Res. 2002
PubMed ID: 11809883
Polymorphisms and HNPCC: PMS2-MLH1 protein interactions diminished by single nucleotide polymorphisms.
Yuan ZQ, Gottlieb B, Beitel LK, Wong N, Gordon PH, Wang Q, Puisieux A, Foulkes WD, Trifiro M
Hum Mutat. 2002
PubMed ID: 11793469
Functional analysis of MLH1 mutations linked to hereditary nonpolyposis colon cancer.
Nyström-Lahti M, Perrera C, Räschle M, Panyushkina-Seiler E, Marra G, Curci A, Quaresima B, Costanzo F, D'Urso M, Venuta S, Jiricny J
Genes Chromosomes Cancer. 2002
PubMed ID: 11793442
E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints.
Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD
Genes Dev. 2002
PubMed ID: 11799067
DNA mismatch repair defects: role in colorectal carcinogenesis.
Jacob S, Praz F
Biochimie. 2002
PubMed ID: 11900875
Mutational analysis of promoters of mismatch repair genes hMSH2 and hMLH1 in hereditary nonpolyposis colorectal cancer and early onset colorectal cancer patients: identification of three novel germ-line mutations in promoter of the hMSH2 gene.
Shin KH, Shin JH, Kim JH, Park JG
Cancer Res. 2002
PubMed ID: 11782355
Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system.
Trojan J, Zeuzem S, Randolph A, Hemmerle C, Brieger A, Raedle J, Plotz G, Jiricny J, Marra G
Gastroenterology. 2002
PubMed ID: 11781295
Seven novel MLH1 and MSH2 germline mutations in hereditary nonpolyposis colorectal cancer.
Krüger S, Plaschke J, Pistorius S, Jeske B, Haas S, Krämer H, Hinterseher I, Bier A, Kreuz FR, Theissig F, Saeger HD, Schackert HK
Hum Mutat. 2002
PubMed ID: 11754112
Eight novel germline MLH1 and MSH2 mutations in hereditary non-polyposis colorectal cancer families from Spain.
Godino J, de La Hoya M, Diaz-Rubio E, Benito M, Caldés T
Hum Mutat. 2001
PubMed ID: 11748856
Sixteen rare sequence variants of the hMLH1 and hMSH2 genes found in a cohort of 254 suspected HNPCC (hereditary non-polyposis colorectal cancer) patients: mutations or polymorphisms?
Müller-Koch Y, Kopp R, Lohse P, Baretton G, Stoetzer A, Aust D, Daum J, Kerker B, Gross M, Dietmeier W, Holinski-Feder E
Eur J Med Res. 2001
PubMed ID: 11726306
Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1.
Pedrazzi G, Perrera C, Blaser H, Kuster P, Marra G, Davies SL, Ryu GH, Freire R, Hickson ID, Jiricny J, Stagljar I
Nucleic Acids Res. 2001
PubMed ID: 11691925
MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families.
Vasen HF, Stormorken A, Menko FH, Nagengast FM, Kleibeuker JH, Griffioen G, Taal BG, Moller P, Wijnen JT
J Clin Oncol. 2001
PubMed ID: 11600610
The colon cancer burden of genetically defined hereditary nonpolyposis colon cancer.
Samowitz WS, Curtin K, Lin HH, Robertson MA, Schaffer D, Nichols M, Gruenthal K, Leppert MF, Slattery ML
Gastroenterology. 2001
PubMed ID: 11606497
Molecular screening for hereditary nonpolyposis colorectal cancer: a prospective, population-based study.
Percesepe A, Borghi F, Menigatti M, Losi L, Foroni M, Di Gregorio C, Rossi G, Pedroni M, Sala E, Vaccina F, Roncucci L, Benatti P, Viel A, Genuardi M, Marra G, Kristo P, Peltomäki P, Ponz de Leon M
J Clin Oncol. 2001
PubMed ID: 11579115
The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas.
Cunningham JM, Kim CY, Christensen ER, Tester DJ, Parc Y, Burgart LJ, Halling KC, McDonnell SK, Schaid DJ, Walsh Vockley C, Kubly V, Nelson H, Michels VV, Thibodeau SN
Am J Hum Genet. 2001
PubMed ID: 11524701
Motivations and psychosocial impact of genetic testing for HNPCC.
Esplen MJ, Madlensky L, Butler K, McKinnon W, Bapat B, Wong J, Aronson M, Gallinger S
Am J Med Genet. 2001
PubMed ID: 11562928
Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae.
Ellison AR, Lofing J, Bitter GA
Hum Mol Genet. 2001
PubMed ID: 11555625
The interaction of DNA mismatch repair proteins with human exonuclease I.
Schmutte C, Sadoff MM, Shim KS, Acharya S, Fishel R
J Biol Chem. 2001
PubMed ID: 11427529
The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair.
Langland G, Kordich J, Creaney J, Goss KH, Lillard-Wetherell K, Bebenek K, Kunkel TA, Groden J
J Biol Chem. 2001
PubMed ID: 11325959
Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha.
Freire R, d'Adda Di Fagagna F, Wu L, Pedrazzi G, Stagljar I, Hickson ID, Jackson SP
Nucleic Acids Res. 2001
PubMed ID: 11470874
Hereditary and somatic DNA mismatch repair gene mutations in sporadic endometrial carcinoma.
Chadwick RB, Pyatt RE, Niemann TH, Richards SK, Johnson CK, Stevens MW, Meek JE, Hampel H, Prior TW, de la Chapelle A
J Med Genet. 2001
PubMed ID: 11474654
Contribution of germline MLH1 and MSH2 mutations to lobular carcinoma in situ of the breast.
Stone JG, Coleman G, Gusterson B, Marossy A, Lakhani SR, Ward A, Nash A, McKinna A, A'Hern R, Stratton MR, Houlston RS
Cancer Lett. 2001
PubMed ID: 11369138
HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes.
Jäger AC, Rasmussen M, Bisgaard HC, Singh KK, Nielsen FC, Rasmussen LJ
Oncogene. 2001
PubMed ID: 11429708
Extensive somatic microsatellite mutations in normal human tissue.
Vilkki S, Tsao JL, Loukola A, Pöyhönen M, Vierimaa O, Herva R, Aaltonen LA, Shibata D
Cancer Res. 2001
PubMed ID: 11389087
Germline characterization of early-aged onset of hereditary non-polyposis colorectal cancer.
Huang SC, Lavine JE, Boland PS, Newbury RO, Kolodner R, Pham TT, Arnold CN, Boland CR, Carethers JM
J Pediatr. 2001
PubMed ID: 11343035
Stepwise deletions of polyA sequences in mismatch repair-deficient colorectal cancers.
Blake C, Tsao JL, Wu A, Shibata D
Am J Pathol. 2001
PubMed ID: 11337385
The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2.
Kondo E, Horii A, Fukushige S
Nucleic Acids Res. 2001
PubMed ID: 11292842
DNA mismatch repair and cancer.
Peltomäki P
Mutat Res. 2001
PubMed ID: 11223406
The sequence of the human genome.
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Science. 2001
PubMed ID: 11181995
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Elevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cells.
Baross-Francis A, Makhani N, Liskay RM, Jirik FR
Oncogene. 2001
PubMed ID: 11313994
Germline mutation analysis of the transforming growth factor beta receptor type II (TGFBR2) and E-cadherin (CDH1) genes in early onset and familial colorectal cancer.
Verma L, Porter TR, Richards FM, Rajpar MH, Evans DG, Macdonald F, Maher ER
J Med Genet. 2001
PubMed ID: 11158177
hMLH1 and hMSH2 mutations in families with familial clustering of gastric cancer and hereditary non-polyposis colorectal cancer.
Kim JC, Kim HC, Roh SA, Koo KH, Lee DH, Yu CS, Lee JH, Kim TW, Lee HL, Beck NE, Bodmer WF
Cancer Detect Prev. 2001
PubMed ID: 12132870
Promoter methylation status of the DNA repair genes hMLH1 and MGMT in gastric carcinoma and metaplastic mucosa.
Oue N, Sentani K, Yokozaki H, Kitadai Y, Ito R, Yasui W
Pathobiology. 2001
PubMed ID: 11872960
Efficient detection of hereditary nonpolyposis colorectal cancer gene carriers by screening for tumor microsatellite instability before germline genetic testing.
Terdiman JP, Gum JR, Conrad PG, Miller GA, Weinberg V, Crawley SC, Levin TR, Reeves C, Schmitt A, Hepburn M, Sleisenger MH, Kim YS
Gastroenterology. 2001
PubMed ID: 11208710
Optimization of experimental conditions for RNA-based sequencing of MLH1 and MSH2 genes.
Jakubowska A, Górski B, Kurzawski G, Debniak T, Hadaczek P, Cybulski C, Kladny J, Oszurek O, Scott RJ, Lubinski J
Hum Mutat. 2001
PubMed ID: 11139242
Population carrier frequency of hMSH2 and hMLH1 mutations.
Dunlop MG, Farrington SM, Nicholl I, Aaltonen L, Petersen G, Porteous M, Carothers A
Br J Cancer. 2000
PubMed ID: 11104559
Tumor-associated Apc mutations in Mlh1-/- Apc1638N mice reveal a mutational signature of Mlh1 deficiency.
Kuraguchi M, Edelmann W, Yang K, Lipkin M, Kucherlapati R, Brown AM
Oncogene. 2000
PubMed ID: 11126362
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
MSH4 acts in conjunction with MLH1 during mammalian meiosis.
Santucci-Darmanin S, Walpita D, Lespinasse F, Desnuelle C, Ashley T, Paquis-Flucklinger V
FASEB J. 2000
PubMed ID: 10928988
Mutational germline analysis of hMSH2 and hMLH1 genes in early onset colorectal cancer patients.
Montera M, Resta N, Simone C, Guanti G, Marchese C, Civitelli S, Mancini A, Pozzi S, De Salvo L, Bruzzone D, Donadini A, Romio L, Mareni C
J Med Genet. 2000
PubMed ID: 10882759
Identification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNA.
Matton N, Simonetti J, Williams K
J Biol Chem. 2000
PubMed ID: 10748159
Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice.
Shoemaker AR, Haigis KM, Baker SM, Dudley S, Liskay RM, Dove WF
Oncogene. 2000
PubMed ID: 10851078
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice.
Kneitz B, Cohen PE, Avdievich E, Zhu L, Kane MF, Hou H, Kolodner RD, Kucherlapati R, Pollard JW, Edelmann W
Genes Dev. 2000
PubMed ID: 10809667
Enhanced detection of deleterious and other germline mutations of hMSH2 and hMLH1 in Japanese hereditary nonpolyposis colorectal cancer kindreds.
Nomura S, Sugano K, Kashiwabara H, Taniguchi T, Fukayama N, Fujita S, Akasu T, Moriya Y, Ohhigashi S, Kakizoe T, Sekiya T
Biochem Biophys Res Commun. 2000
PubMed ID: 10777691
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J
Genes Dev. 2000
PubMed ID: 10783165
Efficient repair of A/C mismatches in mouse cells deficient in long-patch mismatch repair.
Oda S, Humbert O, Fiumicino S, Bignami M, Karran P
EMBO J. 2000
PubMed ID: 10747038
A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice.
Kawate H, Itoh R, Sakumi K, Nakabeppu Y, Tsuzuki T, Ide F, Ishikawa T, Noda T, Nawata H, Sekiguchi M
Carcinogenesis. 2000
PubMed ID: 10657972
Detection of mutations in mismatch repair genes in Portuguese families with hereditary non-polyposis colorectal cancer (HNPCC) by a multi-method approach.
Fidalgo P, Almeida MR, West S, Gaspar C, Maia L, Wijnen J, Albuquerque C, Curtis A, Cravo M, Fodde R, Leitao CN, Burn J
Eur J Hum Genet. 2000
PubMed ID: 10713887
MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability.
Lipkin SM, Wang V, Jacoby R, Banerjee-Basu S, Baxevanis AD, Lynch HT, Elliott RM, Collins FS
Nat Genet. 2000
PubMed ID: 10615123
Cloning of rat MLH1 and expression analysis of MSH2, MSH3, MSH6, and MLH1 during spermatogenesis.
Geeta Vani R, Varghese CM, Rao MR
Genomics. 1999
PubMed ID: 10644444
Missense mutations in hMLH1 associated with colorectal cancer.
Liu T, Tannergård P, Hackman P, Rubio C, Kressner U, Lindmark G, Hellgren D, Lambert B, Lindblom A
Hum Genet. 1999
PubMed ID: 10598809
Assessment of pathogenicity criteria for constitutional missense mutations of the hereditary nonpolyposis colorectal cancer genes MLH1 and MSH2.
Genuardi M, Carrara S, Anti M, Ponz de Leòn M, Viel A
Eur J Hum Genet. 1999
PubMed ID: 10573010
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes.
Schrader CE, Edelmann W, Kucherlapati R, Stavnezer J
J Exp Med. 1999
PubMed ID: 10430621
Frequent microsatellite instability and mismatch repair gene mutations in young Chinese patients with colorectal cancer.
Chan TL, Yuen ST, Chung LP, Ho JW, Kwan KY, Chan AS, Ho JC, Leung SY, Wyllie AH
J Natl Cancer Inst. 1999
PubMed ID: 10413423
Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications.
Kim N, Bozek G, Lo JC, Storb U
J Exp Med. 1999
PubMed ID: 10429667
Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer.
Wang Q, Lasset C, Desseigne F, Saurin JC, Maugard C, Navarro C, Ruano E, Descos L, Trillet-Lenoir V, Bosset JF, Puisieux A
Hum Genet. 1999
PubMed ID: 10480359
Chromosomal influence on meiotic spindle assembly: abnormal meiosis I in female Mlh1 mutant mice.
Woods LM, Hodges CA, Baart E, Baker SM, Liskay M, Hunt PA
J Cell Biol. 1999
PubMed ID: 10385520
Novel hMLH1 and hMSH2 germline mutations in African Americans with colorectal cancer.
Weber TK, Chin HM, Rodriguez-Bigas M, Keitz B, Gilligan R, O'Malley L, Urf E, Diba N, Pazik J, Petrelli NJ
JAMA. 1999
PubMed ID: 10386556
Influence of selection criteria on mutation detection in patients with hereditary nonpolyposis colorectal cancer.
Heinimann K, Scott RJ, Buerstedde JM, Weber W, Siebold K, Attenhofer M, Müller H, Dobbie Z
Cancer. 1999
PubMed ID: 10375096
Different mutator phenotypes in Mlh1- versus Pms2-deficient mice.
Yao X, Buermeyer AB, Narayanan L, Tran D, Baker SM, Prolla TA, Glazer PM, Liskay RM, Arnheim N
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10359802
Microsatellite instability-a useful diagnostic tool to select patients at high risk for hereditary non-polyposis colorectal cancer: a study in different groups of patients with colorectal cancer.
Lamberti C, Kruse R, Ruelfs C, Caspari R, Wang Y, Jungck M, Mathiak M, Malayeri HR, Friedl W, Sauerbruch T, Propping P
Gut. 1999
PubMed ID: 10323887
MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1.
Bellacosa A, Cicchillitti L, Schepis F, Riccio A, Yeung AT, Matsumoto Y, Golemis EA, Genuardi M, Neri G
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10097147
Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice.
Edelmann W, Yang K, Kuraguchi M, Heyer J, Lia M, Kneitz B, Fan K, Brown AM, Lipkin M, Kucherlapati R
Cancer Res. 1999
PubMed ID: 10096563
Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein.
Phung QH, Winter DB, Alrefai R, Gearhart PJ
J Immunol. 1999
PubMed ID: 10092760
The interaction of the human MutL homologues in hereditary nonpolyposis colon cancer.
Guerrette S, Acharya S, Fishel R
J Biol Chem. 1999
PubMed ID: 10037723
Neurofibromatosis and early onset of cancers in hMLH1-deficient children.
Wang Q, Lasset C, Desseigne F, Frappaz D, Bergeron C, Navarro C, Ruano E, Puisieux A
Cancer Res. 1999
PubMed ID: 9927034
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Excess of hMLH1 germline mutations in Swiss families with hereditary non-polyposis colorectal cancer.
Hutter P, Couturier A, Membrez V, Joris F, Sappino AP, Chappuis PO
Int J Cancer. 1998
PubMed ID: 9833759
Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis.
Ban C, Yang W
Cell. 1998
PubMed ID: 9827806
I1307K APC and hMLH1 mutations in a non-Jewish family with hereditary non-polyposis colorectal cancer.
Yuan ZQ, Kasprzak L, Gordon PH, Pinsky L, Foulkes WD
Clin Genet. 1998
PubMed ID: 9831355
Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls.
Farrington SM, Lin-Goerke J, Ling J, Wang Y, Burczak JD, Robbins DJ, Dunlop MG
Am J Hum Genet. 1998
PubMed ID: 9718327
Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes.
Kawate H, Sakumi K, Tsuzuki T, Nakatsuru Y, Ishikawa T, Takahashi S, Takano H, Noda T, Sekiguchi M
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9560238
Germline mutations of hMLH1 and hMSH2 genes in patients with suspected hereditary nonpolyposis colorectal cancer and sporadic early-onset colorectal cancer.
Yuan Y, Han HJ, Zheng S, Park JG
Dis Colon Rectum. 1998
PubMed ID: 9559627
A novel missense mutation in the DNA mismatch repair gene hMLH1 present among East Asians but not among Europeans.
Wang Y, Friedl W, Lamberti C, Nöthen MM, Kruse R, Propping P
Hum Hered. 1998
PubMed ID: 9526167
Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair.
Prolla TA, Baker SM, Harris AC, Tsao JL, Yao X, Bronner CE, Zheng B, Gordon M, Reneker J, Arnheim N, Shibata D, Bradley A, Liskay RM
Nat Genet. 1998
PubMed ID: 9500552
DGGE screening of mutations in mismatch repair genes (hMSH2 and hMLH1) in 34 Swedish families with colorectal cancer.
Liu T, Wahlberg S, Rubio C, Holmberg E, Grönberg H, Lindblom A
Clin Genet. 1998
PubMed ID: 9611074
Characterization of MLH1 and MSH2 alternative splicing and its relevance to molecular testing of colorectal cancer susceptibility.
Genuardi M, Viel A, Bonora D, Capozzi E, Bellacosa A, Leonardi F, Valle R, Ventura A, Pedroni M, Boiocchi M, Neri G
Hum Genet. 1998
PubMed ID: 9490293
Hereditary nonpolyposis coloretal cancer: identification of novel germline mutations in two kindreds not fulfulling the Amsterdam criteria. Mutations in brief no. 203. Online.
Quaresima B, Grandinetti C, Baudi F, Tassone P, Barbieri V, Conforti S, Avvedimento EV, Costanzo F, Venuta S
Hum Mutat. 1998
PubMed ID: 10671064
hMLH1 mutations in hereditary nonpolyposis colorectal cancer kindreds. Mutations in brief no. 182. Online.
Panariello L, Scarano MI, de Rosa M, Capasso L, Renda A, Riegler G, Rossi GB, Salvatore F, Izzo P
Hum Mutat. 1998
PubMed ID: 10660333
Four new mutations in the DNA mismatch repair gene MLH1 in colorectal cancers with microsatellite instability. Mutations in brief no. 157. Online.
Klaus K, Herfarth F, Ogunbiyi OA, Moley JF, Kodner IJ, Wells SA, Goodfellow PJ
Hum Mutat. 1998
PubMed ID: 10627141
Germline hMSH2 and hMLH1 gene mutations in incomplete HNPCC families.
Wang Q, Desseigne F, Lasset C, Saurin JC, Navarro C, Yagci T, Keser I, Bagci H, Luleci G, Gelen T, Chayvialle JA, Puisieux A, Ozturk M
Int J Cancer. 1997
PubMed ID: 9399661
Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
Gene. 1997
PubMed ID: 9373149
A human compound heterozygote for two MLH1 missense mutations.
Hackman P, Tannergård P, Osei-Mensa S, Chen J, Kane MF, Kolodner R, Lambert B, Hellgren D, Lindblom A
Nat Genet. 1997
PubMed ID: 9326924
Hereditary nonpolyposis colorectal cancer: causative role of a germline missense mutation in the hMLH1 gene confirmed by the independent occurrence of the same somatic mutation in tumour tissue.
Wang Y, Friedl W, Lamberti C, Ruelfs C, Kruse R, Propping P
Hum Genet. 1997
PubMed ID: 9272156
Hereditary nonpolyposis colorectal cancer families not complying with the Amsterdam criteria show extremely low frequency of mismatch-repair-gene mutations.
Wijnen J, Khan PM, Vasen H, van der Klift H, Mulder A, van Leeuwen-Cornelisse I, Bakker B, Losekoot M, Møller P, Fodde R
Am J Hum Genet. 1997
PubMed ID: 9311737
Reduced frequency of extracolonic cancers in hereditary nonpolyposis colorectal cancer families with monoallelic hMLH1 expression.
Jäger AC, Bisgaard ML, Myrhøj T, Bernstein I, Rehfeld JF, Nielsen FC
Am J Hum Genet. 1997
PubMed ID: 9245993
Mean age of tumor onset in hereditary nonpolyposis colorectal cancer (HNPCC) families correlates with the presence of mutations in DNA mismatch repair genes.
Pensotti V, Radice P, Presciuttini S, Calistri D, Gazzoli I, Grimalt Perez A, Mondini P, Buonsanti G, Sala P, Rossetti C, Ranzani GN, Bertario L, Pierotti MA
Genes Chromosomes Cancer. 1997
PubMed ID: 9218993
MSH2 and MLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis.
Wu Y, Nyström-Lahti M, Osinga J, Looman MW, Peltomäki P, Aaltonen LA, de la Chapelle A, Hofstra RM, Buys CH
Genes Chromosomes Cancer. 1997
PubMed ID: 9087566
Use of SSCP analysis to identify germline mutations in HNPCC families fulfilling the Amsterdam criteria.
Beck NE, Tomlinson IP, Homfray T, Frayling I, Hodgson SV, Harocopos C, Bodmer WF
Hum Genet. 1997
PubMed ID: 9048925
Hereditary nonpolyposis colorectal cancer (HNPCC): eight novel germline mutations in hMSH2 or hMLH1 genes.
Wehner M, Buschhausen L, Lamberti C, Kruse R, Caspari R, Propping P, Friedl W
Hum Mutat. 1997
PubMed ID: 9298827
Molecular basis of HNPCC: mutations of MMR genes.
Papadopoulos N, Lindblom A
Hum Mutat. 1997
PubMed ID: 9259192
Mutations predisposing to hereditary nonpolyposis colorectal cancer.
Peltomäki P, de la Chapelle A
Adv Cancer Res. 1997
PubMed ID: 9111864
Mutational analysis of the hMLH1 gene using an automated two-dimensional DNA typing system.
Sasaki S, Tokino T, Miyatsu T, Muto T, Nakamura Y
Hum Mutat. 1997
PubMed ID: 9067757
Germline HNPCC gene variants have little influence on the risk for sporadic colorectal cancer.
Tomlinson IP, Beck NE, Homfray T, Harocopos CJ, Bodmer WF
J Med Genet. 1997
PubMed ID: 9032648
Characterization of MSH2 and MLH1 mutations in Italian families with hereditary nonpolyposis colorectal cancer.
Viel A, Genuardi M, Capozzi E, Leonardi F, Bellacosa A, Paravatou-Petsotas M, Pomponi MG, Fornasarig M, Percesepe A, Roncucci L, Tamassia MG, Benatti P, Ponz de Leon M, Valenti A, Covino M, Anti M, Foletto M, Boiocchi M, Neri G
Genes Chromosomes Cancer. 1997
PubMed ID: 8993976
Age and origin of two common MLH1 mutations predisposing to hereditary colon cancer.
Moisio AL, Sistonen P, Weissenbach J, de la Chapelle A, Peltomäki P
Am J Hum Genet. 1996
PubMed ID: 8940269
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6.
Acharya S, Wilson T, Gradia S, Kane MF, Guerrette S, Marsischky GT, Kolodner R, Fishel R
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8942985
Germline mutations of hMLH1 and hMSH2 genes in Korean hereditary nonpolyposis colorectal cancer.
Han HJ, Yuan Y, Ku JL, Oh JH, Won YJ, Kang KJ, Kim KY, Kim S, Kim CY, Kim JP, Oh NG, Lee KH, Choe KJ, Nakamura Y, Park JG
J Natl Cancer Inst. 1996
PubMed ID: 8797773
Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer.
Moslein G, Tester DJ, Lindor NM, Honchel R, Cunningham JM, French AJ, Halling KC, Schwab M, Goretzki P, Thibodeau SN
Hum Mol Genet. 1996
PubMed ID: 8872463
The genetic basis of Muir-Torre syndrome includes the hMLH1 locus.
Bapat B, Xia L, Madlensky L, Mitri A, Tonin P, Narod SA, Gallinger S
Am J Hum Genet. 1996
PubMed ID: 8751876
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over.
Baker SM, Plug AW, Prolla TA, Bronner CE, Harris AC, Yao X, Christie DM, Monell C, Arnheim N, Bradley A, Ashley T, Liskay RM
Nat Genet. 1996
PubMed ID: 8673133
Meiotic pachytene arrest in MLH1-deficient mice.
Edelmann W, Cohen PE, Kane M, Lau K, Morrow B, Bennett S, Umar A, Kunkel T, Cattoretti G, Chaganti R, Pollard JW, Kolodner RD, Kucherlapati R
Cell. 1996
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Molecular cloning and tissue distribution of mouse protein C inhibitor (PCI).
Zechmeister-Machhart M, Hufnagl P, Uhrin P, Xu J, Geiger M, Binder BR
Immunopharmacology. 1996
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Mutational analysis of mismatch repair genes, hMLH1 and hMSH2, in sporadic endometrial carcinomas with microsatellite instability.
Kobayashi K, Matsushima M, Koi S, Saito H, Sagae S, Kudo R, Nakamura Y
Jpn J Cancer Res. 1996
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Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16.
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CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations.
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Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	4292	17350	81685
EnsEMBL Gene(s)	ENSG00000076242	ENSMUSG00000032498	ENSRNOG00000033809
Unigene	Hs.195364	Mm.486383	Rn.20391
Homologene	MLH1	Mlh1	Mlh1
OMIM	120436	N/A	N/A
GeneCards	MLH1	N/A	N/A
Beta Cell Genomics	DT.100028705 DT.100810259 DT.101980402 DT.120923014 DT.445647 DT.95333713	DT.101140778 DT.490690 DT.94219805	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	4292	17350	81685

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
MLH1	RAD50	BioGRID	empirical	10783165
MLH1	NDRG1	IntAct	empirical	20706999
MLH1	ZER1	IntAct	empirical	20706999
MLH1	AGR2	IntAct	empirical	20706999
MLH1	RUVBL2	BioGRID	empirical	17148452
MLH1	CKAP4	IntAct	empirical	20706999
MLH1	EXOC3	IntAct	empirical	20706999
MLH1	GABARAP	IntAct	empirical	20706999
MLH1	FBXO32	IntAct	empirical	20706999
MLH1	NT5C3L	IntAct	empirical	20706999
MLH1	CKB	IntAct	empirical	20706999
MLH1	CLIC1	IntAct	empirical	20706999
MLH1	ADSSL1	Sanger Interaction Map	predicted	15345047
MLH1	FRMD6	HPRD, MINT, IntAct, BioGRID	empirical	16189514
MLH1	TPRG1L	IntAct	empirical	20706999
MLH1	COPA	IntAct	empirical	20706999
MLH1	ATF2	IntAct	empirical	21988832
MLH1	CTSB	IntAct	empirical	20706999
MLH1	AMOT	BioGRID	empirical	17148452
MLH1	AP2B1	HPRD, MINT, IntAct, BioGRID	empirical	16189514
MLH1	DES	IntAct	empirical	20706999
MLH1	EEF1G	IntAct	empirical	20706999
MLH1	EEF2	IntAct	empirical	20706999
MLH1	ALDOA	IntAct	empirical	20706999
MLH1	UBOX5	HPRD, IntAct, BioGRID	empirical	16189514
MLH1	FAN1	BioGRID	empirical	17148452 20603073 20603015
MLH1	FLNB	IntAct	empirical	20706999
MLH1	FLNC	IntAct	empirical	20706999
MLH1	PSD3	BioGRID	empirical	17148452
MLH1	TRIM29	HPRD, MINT, IntAct, BioGRID	empirical	16189514
MLH1	TXN2	IntAct	empirical	20706999
MLH1	MLH3	HPRD, BioGRID, Reactome	empirical	10615123 11292842
MLH1	GSTP1	IntAct	empirical	20706999
MLH1	MSH6	BioGRID	empirical	10783165
MLH1	SEC61A1	IntAct	empirical	20706999
MLH1	ANXA2	IntAct	empirical	20706999
MLH1	ANXA6	IntAct	empirical	20706999
MLH1	HSD17B3	IntAct	empirical	20706999
MLH1	IGHM	IntAct	empirical	20706999
MLH1	IGKC	IntAct	empirical	20706999
MLH1	APRT	IntAct	empirical	20706999
MLH1	ARAF	IntAct	empirical	20706999
MLH1	TRIM23	IntAct	empirical	20706999
MLH1	KPNB1	BioGRID	empirical	17148452
MLH1	KPNA2	BioGRID	empirical	17148452
MLH1	LGALS4	IntAct	empirical	20706999
MLH1	MSH2	BioGRID	empirical	10783165
MLH1	MSH3	BioGRID	empirical	17148452
MLH1	MSH4	HPRD, BioGRID	empirical	10928988
MLH1	ASS1	IntAct	empirical	20706999
MLH1	MUC2	IntAct	empirical	20706999
MLH1	MYC	HPRD, BioGRID	empirical	12584560
MLH1	MYL6	IntAct	empirical	20706999
MLH1	NBN	BioGRID	empirical	10783165
MLH1	NCF4	IntAct	empirical	20706999
MLH1	NDUFS8	IntAct	empirical	20706999
MLH1	NONO	IntAct	empirical	20706999
MLH1	NUCB2	Sanger Interaction Map	predicted	15345047
MLH1	ATP5A1	BioGRID	empirical	17148452
MLH1	ACO2	IntAct	empirical	20706999
MLH1	ORC4	IntAct	empirical	21988832
MLH1	RAPGEFL1	IntAct	empirical	20706999
MLH1	DDX47	IntAct	empirical	20706999
MLH1	CUTA	IntAct	empirical	20706999
MLH1	SERPINF1	IntAct	empirical	20706999
MLH1	PIK3C2A	BioGRID	empirical	17148452
MLH1	PMS1	HPRD, BioGRID	empirical	11292842 17148452 20004149
MLH1	IL20RA	IntAct	empirical	20706999
MLH1	PMS2	HPRD, IntAct, Sanger Interaction Map	empirical	11292842 10037723 11429708 14676842 12810663 11793469 20706999 15345047
MLH1	XRN1	BioGRID	empirical	17148452
MLH1	NDFIP2	IntAct	empirical	20706999
MLH1	TRIT1	Sanger Interaction Map	predicted	15345047
MLH1	C3orf75	IntAct	empirical	20706999
MLH1	PPP2R1A	BioGRID	empirical	17148452
MLH1	PPP2R2A	BioGRID	empirical	17148452
MLH1	PPP2R2B	BioGRID	empirical	17148452
MLH1	ATAD3A	BioGRID	empirical	17148452
MLH1	PPP3CB	BioGRID	empirical	17148452
MLH1	PPP3CC	BioGRID	empirical	17148452
MLH1	ACER3	IntAct	empirical	20706999
MLH1	STAP2	IntAct	empirical	20706999
MLH1	PARVA	IntAct	empirical	20706999
MLH1	PPP2R2D	BioGRID	empirical	17148452
MLH1	PRKDC	BioGRID	empirical	17148452
MLH1	MAP2K6	IntAct	empirical	20706999
MLH1	YLPM1	BioGRID	empirical	17148452
MLH1	BACH1	BioGRID	empirical	16391231
MLH1	PTGDS	IntAct	empirical	20706999
MLH1	PTPRH	IntAct	empirical	20706999
MLH1	BARD1	BioGRID	empirical	16391231
MLH1	PYGB	BioGRID	empirical	17148452
MLH1	RAD9A	HPRD	empirical	18842633
MLH1	RAD23B	IntAct	empirical	20706999
MLH1	RFC1	BioGRID	empirical	10783165
MLH1	FASTKD5	MINT	empirical	16189514
MLH1	RPS2	IntAct	empirical	20706999
MLH1	RPS5	IntAct	empirical	20706999
MLH1	RPS16	IntAct	empirical	20706999
MLH1	RRBP1	IntAct	empirical	20706999
MLH1	BLM	HPRD, BioGRID	empirical	11691925 11325959 19015241 10783165 11470874 12724401
MLH1	PARP12	IntAct	empirical	20706999
MLH1	FSCN1	IntAct	empirical	20603015
MLH1	SPTAN1	IntAct	empirical	20706999
MLH1	BRCA1	HPRD, BioGRID	empirical	10783165 17148452 21240188
MLH1	TAGLN	IntAct	empirical	20706999
MLH1	ACTG1	IntAct	empirical	20706999
MLH1	TMSB4X	IntAct	empirical	17967441 20706999
MLH1	ACTG2	IntAct	empirical	20706999
MLH1	CAPN5	IntAct	empirical	20706999
MLH1	TXN	IntAct	empirical	21988832
MLH1	UBC	BioGRID	empirical	17148452 21139048
MLH1	C11orf2	IntAct	empirical	20706999
MLH1	SLC25A23	IntAct	empirical	20706999
MLH1	ABHD16A	IntAct	empirical	20706999
MLH1	WDR61	BioGRID	empirical	17148452
MLH1	PTP4A2	IntAct	empirical	20706999
MLH1	CAB39L	IntAct	empirical	20706999
MLH1	SMC1A	BioGRID	empirical	17148452
MLH1	CASP3	HPRD	empirical	15087450
MLH1	ATAD3B	BioGRID	empirical	17148452
MLH1	EIF2A	IntAct	empirical	20706999
MLH1	BRIP1	MINT	empirical	17581638
MLH1	DOCK7	BioGRID	empirical	17148452
MLH1	RUVBL1	BioGRID	empirical	17148452
MLH1	PPAP2C	IntAct	empirical	20706999
MLH1	VAMP8	IntAct	empirical	20706999
MLH1	ABCC3	IntAct	empirical	20706999
MLH1	FCGBP	IntAct	empirical	20706999
MLH1	SQSTM1	IntAct	empirical	20706999
MLH1	MBD4	HPRD	empirical	10097147
MLH1	SELENBP1	IntAct	empirical	20706999
MLH1	AIFM1	IntAct, BioGRID	empirical	20706999 17148452
MLH1	EXO1	HPRD, BioGRID	empirical	11427529 11429708 14676842 19015241 17148452 21533173 22222486
MLH1	ZC3H11A	HPRD, MINT, IntAct, BioGRID	empirical	16189514 19060904
MLH1	UBAP2L	BioGRID	empirical	17148452