ARRB2

Summary Top Help

Gene Description:

arrestin, beta 2

Synonyms:

RP23-42P20.7, AI326910, BARR2, ARR2, AW122872, ARB2, ARRB2, Arrb2, BARRES

Orthologs:

Human ARRB2 (protein-coding), Mouse Arrb2 (protein-coding), Rat Arrb2 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd4.1	Mouse	chr11:69761993..71151314	1.39	60

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr17:4613784..4624795 (111 kb) View in Genome Browser

(Mouse) NCBIM37 - chr11:70246137..70254330 (8.19 kb) View in Genome Browser

(Rat) RGSC3.4 - chr10:57244071..57284166 (409 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for ARRB2:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for ARRB2:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 5

Biocarta: None available

Reactome: 5

NCI-Nature Pathway Interaction Database: 12

Gene Ontology: 29

Publications from PubMed Top Help

Publications: 325

β-arrestin2 plays permissive roles in the inhibitory activities of RGS9-2 on G protein-coupled receptors by maintaining RGS9-2 in the open conformation.
Zheng M, Cheong SY, Min C, Jin M, Cho DI, Kim KM
Mol Cell Biol. 2011
PubMed ID: 22006018
β-arrestin2 mediates β-2 adrenergic receptor signaling inducing prostate cancer cell progression.
Zhang P, He X, Tan J, Zhou X, Zou L
Oncol Rep. 2011
PubMed ID: 21833475
Antinociceptive potentiation and attenuation of tolerance by intrathecal β-arrestin 2 small interfering RNA in rats.
Yang CH, Huang HW, Chen KH, Chen YS, Sheen-Chen SM, Lin CR
Br J Anaesth. 2011
PubMed ID: 21926413
Gender related alterations of β-adrenoceptor mechanisms in heart failure due to arteriovenous fistula.
Dent MR, Tappia PS, Dhalla NS
J Cell Physiol. 2011
PubMed ID: 22015551
Increased expression of beta-arrestin 1 and 2 in murine models of rheumatoid arthritis: isoform specific regulation of inflammation.
Li P, Cook JA, Gilkeson GS, Luttrell LM, Wang L, Borg KT, Halushka PV, Fan H
Mol Immunol. 2011
PubMed ID: 21855149
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ
Nature. 2011
PubMed ID: 21857681
Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation.
Groer CE, Schmid CL, Jaeger AM, Bohn LM
J Biol Chem. 2011
PubMed ID: 21757712
β-arrestin2 stimulates interleukin-17 production and expression of CD4+ T lymphocytes in a murine asthma model.
Liu Y, Wang GY, Liu SK, Yang MY, Ma LB, Li K, Gong SB, Zhang L, Chen P, Xiang XD
Iran J Allergy Asthma Immunol. 2011
PubMed ID: 21891823
Disruption of β-arrestins blocks glucocorticoid receptor and severely retards lung and liver development in mice.
Zhang M, Teng H, Shi J, Zhang Y
Mech Dev. 2011
PubMed ID: 21824517
Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice.
O'Brien WT, Huang J, Buccafusca R, Garskof J, Valvezan AJ, Berry GT, Klein PS
J Clin Invest. 2011
PubMed ID: 21821916
The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity.
Paavola KJ, Stephenson JR, Ritter SL, Alter SP, Hall RA
J Biol Chem. 2011
PubMed ID: 21708946
Beta-arrestin-1 protein represses adipogenesis and inflammatory responses through its interaction with peroxisome proliferator-activated receptor-gamma (PPARgamma).
Zhuang LN, Hu WX, Xin SM, Zhao J, Pei G
J Biol Chem. 2011
PubMed ID: 21700709
Beta-arrestin-1 protein represses diet-induced obesity.
Zhuang LN, Hu WX, Zhang ML, Xin SM, Jia WP, Zhao J, Pei G
J Biol Chem. 2011
PubMed ID: 21543334
β-arrestin-2 regulation of the cAMP response element binding protein.
Manson ME, Corey DA, Rymut SM, Kelley TJ
Biochemistry. 2011
PubMed ID: 21644508
Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys.
Zakrzewicz A, Krasteva G, Wilhelm J, Dietrich H, Wilker S, Padberg W, Wygrecka M, Grau V
Immunobiology. 2011
PubMed ID: 21193245
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
[The clinical significance of β-arrestin 2 expression in the serum of non-small cell lung cancer patients].
Wu Z, Tong W, Tan Z, Wang S, Lin P
Zhongguo Fei Ai Za Zhi. 2011
PubMed ID: 21645452
EGFR trans-activation by urotensin II receptor is mediated by β-arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy.
Esposito G, Perrino C, Cannavo A, Schiattarella GG, Borgia F, Sannino A, Pironti G, Gargiulo G, Di Serafino L, Franzone A, Scudiero L, Grieco P, Indolfi C, Chiariello M
Basic Res Cardiol. 2011
PubMed ID: 21369867
Temporal profiling of orexin receptor-arrestin-ubiquitin complexes reveals differences between receptor subtypes.
Dalrymple MB, Jaeger WC, Eidne KA, Pfleger KD
J Biol Chem. 2011
PubMed ID: 21378163
Ubiquitin ligase parkin promotes Mdm2-arrestin interaction but inhibits arrestin ubiquitination.
Ahmed MR, Zhan X, Song X, Kook S, Gurevich VV, Gurevich EV
Biochemistry. 2011
PubMed ID: 21466165
Intact MDM2 E3 ligase activity is required for the cytosolic localization and function of β-arrestin2.
Yin C, Zhang R, Xu Y, Chen Q, Xie X
Mol Biol Cell. 2011
PubMed ID: 21389118
PKC alpha mediates beta-arrestin2-dependent nephrin endocytosis in hyperglycemia.
Quack I, Woznowski M, Potthoff SA, Palmer R, Königshausen E, Sivritas S, Schiffer M, Stegbauer J, Vonend O, Rump LC, Sellin L
J Biol Chem. 2011
PubMed ID: 21321125
CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis.
Lukashova V, Szabó EZ, Jinadasa T, Mokhov A, Litchfield DW, Orlowski J
J Biol Chem. 2011
PubMed ID: 21296876
β-arrestin-2 is expressed in human prostate smooth muscle and a binding partner of α1A-adrenoceptors.
Hennenberg M, Schlenker B, Roosen A, Strittmatter F, Walther S, Stief C, Gratzke C
World J Urol. 2011
PubMed ID: 21258807
Chronic stress promotes lymphocyte reduction through TLR2 mediated PI3K signaling in a β-arrestin 2 dependent manner.
Li H, Chen L, Zhang Y, Lesage G, Zhang Y, Wu Y, Hanley G, Sun S, Yin D
J Neuroimmunol. 2011
PubMed ID: 21183229
Binding between a distal C-terminus fragment of cannabinoid receptor 1 and arrestin-2.
Singh SN, Bakshi K, Mercier RW, Makriyannis A, Pavlopoulos S
Biochemistry. 2011
PubMed ID: 21306178
β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix.
Lovgren AK, Kovacs JJ, Xie T, Potts EN, Li Y, Foster WM, Liang J, Meltzer EB, Jiang D, Lefkowitz RJ, Noble PW
Sci Transl Med. 2011
PubMed ID: 21411739
On the existence of a possible A2A-D2-β-Arrestin2 complex: A2A agonist modulation of D2 agonist-induced β-arrestin2 recruitment.
Borroto-Escuela DO, Romero-Fernandez W, Tarakanov AO, Ciruela F, Agnati LF, Fuxe K
J Mol Biol. 2011
PubMed ID: 21256133
β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration.
Grotegut CA, Feng L, Mao L, Heine RP, Murtha AP, Rockman HA
Am J Physiol Endocrinol Metab. 2011
PubMed ID: 21139074
Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats.
Khan MS, Devaraj H, Devaraj N
Toxicol Appl Pharmacol. 2011
PubMed ID: 21167192
Arrestin-2 differentially regulates PAR4 and ADP receptor signaling in platelets.
Li D, D'Angelo L, Chavez M, Woulfe DS
J Biol Chem. 2011
PubMed ID: 21106537
The expression change of β-arrestins in fibroblast-like synoviocytes from rats with collagen-induced arthritis and the effect of total glucosides of paeony.
Wang QT, Zhang LL, Wu HX, Wei W
J Ethnopharmacol. 2011
PubMed ID: 20965243
Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2.
Nogués L, Salcedo A, Mayor F, Penela P
J Biol Chem. 2011
PubMed ID: 21081496
Beta-arrestin2 as a competitor for GRK2 interaction with the GLP-1 receptor upon receptor activation.
Jorgensen R, Norklit Roed S, Heding A, Elling CE
Pharmacology. 2011
PubMed ID: 21952200
Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins.
Lima-Fernandes E, Enslen H, Camand E, Kotelevets L, Boularan C, Achour L, Benmerah A, Gibson LC, Baillie GS, Pitcher JA, Chastre E, Etienne-Manneville S, Marullo S, Scott MG
EMBO J. 2011
PubMed ID: 21642958
Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells.
Vibhuti A, Gupta K, Subramanian H, Guo Q, Ali H
PLoS One. 2011
PubMed ID: 21589858
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
β-arrestin 2-mediated immune suppression induced by chronic stress.
Li H, Smalligan DA, Xie N, Javer A, Zhang Y, Hanley G, Yin D
Neuroimmunomodulation. 2011
PubMed ID: 21228603
Preferential β-arrestin signalling at low receptor density revealed by functional characterization of the human FSH receptor A189 V mutation.
Tranchant T, Durand G, Gauthier C, Crépieux P, Ulloa-Aguirre A, Royère D, Reiter E
Mol Cell Endocrinol. 2011
PubMed ID: 20801186
The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics.
Raehal KM, Bohn LM
Neuropharmacology. 2011
PubMed ID: 20713067
G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling.
Morris GE, Nelson CP, Everitt D, Brighton PJ, Standen NB, Challiss RA, Willets JM
Cardiovasc Res. 2011
PubMed ID: 20705669
{Beta}-blocker drugs mediate calcium signaling in native central nervous system neurons by {beta}-arrestin-biased agonism.
Tzingounis AV, von Zastrow M, Yudowski GA
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21078978
Lack of association between genetic polymorphisms of ARRB2 and alcohol dependence in a Caucasian population.
Oneda B, Preisig M, Dobrinas M, Eap CB
Alcohol Alcohol. 2010
PubMed ID: 20864483
A large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ
Hum Genet. 2010
PubMed ID: 20734064
Regulation of lipopolysaccharide-induced inflammatory response and endotoxemia by beta-arrestins.
Porter KJ, Gonipeta B, Parvataneni S, Appledorn DM, Patial S, Sharma D, Gangur V, Amalfitano A, Parameswaran N
J Cell Physiol. 2010
PubMed ID: 20589830
Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ß-arrestin2/Src/Akt signaling complex in vivo.
Schmid CL, Bohn LM
J Neurosci. 2010
PubMed ID: 20926677
A human MAP kinase interactome.
Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
Nat Methods. 2010
PubMed ID: 20936779
Formation of a ternary complex among NHERF1, beta-arrestin, and parathyroid hormone receptor.
Klenk C, Vetter T, Zürn A, Vilardaga JP, Friedman PA, Wang B, Lohse MJ
J Biol Chem. 2010
PubMed ID: 20656684
Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4.
Shukla AK, Kim J, Ahn S, Xiao K, Shenoy SK, Liedtke W, Lefkowitz RJ
J Biol Chem. 2010
PubMed ID: 20650893
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects.
Oh da Y, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, Olefsky JM
Cell. 2010
PubMed ID: 20813258
Beta-arrestin 2 modulates resveratrol-induced apoptosis and regulation of Akt/GSK3ß pathways.
Sun X, Zhang Y, Wang J, Wei L, Li H, Hanley G, Zhao M, Li Y, Yin D
Biochim Biophys Acta. 2010
PubMed ID: 20457218
Both hematopoietic-derived and non-hematopoietic-derived {beta}-arrestin-2 regulates murine allergic airway disease.
Hollingsworth JW, Theriot BS, Li Z, Lawson BL, Sunday M, Schwartz DA, Walker JK
Am J Respir Cell Mol Biol. 2010
PubMed ID: 19805483
Beta-arrestin 2 regulates Toll-like receptor 4-mediated apoptotic signalling through glycogen synthase kinase-3beta.
Li H, Sun X, LeSage G, Zhang Y, Liang Z, Chen J, Hanley G, He L, Sun S, Yin D
Immunology. 2010
PubMed ID: 20497256
Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependence.
Bousman CA, Glatt SJ, Cherner M, Atkinson JH, Grant I, Tsuang MT, Everall IP, HNRC Group
Psychiatry Res. 2010
PubMed ID: 20478633
Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4.
Malik R, Marchese A
Mol Biol Cell. 2010
PubMed ID: 20505072
Beta-arrestin 2 negatively regulates sepsis-induced inflammation.
Fan H, Bitto A, Zingarelli B, Luttrell LM, Borg K, Halushka PV, Cook JA
Immunology. 2010
PubMed ID: 20465566
Beta-arrestin 2 is required for B1 receptor-dependent post-translational activation of inducible nitric oxide synthase.
Kuhr FK, Zhang Y, Brovkovych V, Skidgel RA
FASEB J. 2010
PubMed ID: 20228252
Troglitazone stimulates beta-arrestin-dependent cardiomyocyte contractility via the angiotensin II type 1A receptor.
Tilley DG, Nguyen AD, Rockman HA
Biochem Biophys Res Commun. 2010
PubMed ID: 20460106
beta-Arrestin2 influences the response to methadone in opioid-dependent patients.
Oneda B, Crettol S, Bochud M, Besson J, Croquette-Krokar M, Hämmig R, Monnat M, Preisig M, Eap CB
Pharmacogenomics J. 2010
PubMed ID: 20514076
KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation.
Rondou P, Skieterska K, Packeu A, Lintermans B, Vanhoenacker P, Vauquelin G, Haegeman G, Van Craenenbroeck K
Cell Signal. 2010
PubMed ID: 20100572
beta-Arrestins scaffold cofilin with chronophin to direct localized actin filament severing and membrane protrusions downstream of protease-activated receptor-2.
Zoudilova M, Min J, Richards HL, Carter D, Huang T, DeFea KA
J Biol Chem. 2010
PubMed ID: 20207744
beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation.
Mangmool S, Shukla AK, Rockman HA
J Cell Biol. 2010
PubMed ID: 20421423
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
Loss of betaarrestin1 and betaarrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice.
Zhang M, Liu X, Zhang Y, Zhao J
Dev Biol. 2010
PubMed ID: 20060823
Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function.
Shankar H, Michal A, Kern RC, Kang DS, Gurevich VV, Benovic JL
J Biol Chem. 2010
PubMed ID: 20056609
Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.
Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, Benovic JL
J Biol Chem. 2010
PubMed ID: 20048153
Overexpression of beta-arrestin 2 in peripheral blood mononuclear cells of patients with cryptococcal meningitis.
Xia R, Hu Z, Sun Y, Chen S, Gu M, Zhou Y, Han Z, Zhong R, Deng A, Wen H
J Interferon Cytokine Res. 2010
PubMed ID: 20035620
Antidepressants increase β-arrestin 2 ubiquitinylation and degradation by the proteasomal pathway in C6 rat glioma cells.
Golan M, Schreiber G, Avissar S
J Pharmacol Exp Ther. 2010
PubMed ID: 19996297
Differences in the C-terminus contribute to variations in trafficking between rat and human 5-HT(2A) receptor isoforms: identification of a primate-specific tripeptide ASK motif that confers GRK-2 and beta arrestin-2 interactions.
Bhattacharya A, Sankar S, Panicker MM
J Neurochem. 2010
PubMed ID: 19919577
Biased signaling of the angiotensin II type 1 receptor can be mediated through distinct mechanisms.
Bonde MM, Hansen JT, Sanni SJ, Haunsø S, Gammeltoft S, Lyngsø C, Hansen JL
PLoS One. 2010
PubMed ID: 21152433
GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner.
Szereszewski JM, Pampillo M, Ahow MR, Offermanns S, Bhattacharya M, Babwah AV
PLoS One. 2010
PubMed ID: 20886089
beta-Arrestins modulate Adenovirus-vector-induced innate immune responses: differential regulation by beta-arrestin-1 and beta-arrestin-2.
Seregin SS, Appledorn DM, Patial S, Bujold M, Nance W, Godbehere S, Parameswaran N, Amalfitano A
Virus Res. 2010
PubMed ID: 19896992
Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning.
Li Y, Li H, Liu X, Bao G, Tao Y, Wu Z, Xia P, Wu C, Li B, Ma L
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19955404
Regulation of GPR54 signaling by GRK2 and {beta}-arrestin.
Pampillo M, Camuso N, Taylor JE, Szereszewski JM, Ahow MR, Zajac M, Millar RP, Bhattacharya M, Babwah AV
Mol Endocrinol. 2009
PubMed ID: 19846537
Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival.
Lattin JE, Greenwood KP, Daly NL, Kelly G, Zidar DA, Clark RJ, Thomas WG, Kellie S, Craik DJ, Hume DA, Sweet MJ
Mol Immunol. 2009
PubMed ID: 19783052
Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2.
García Lopez MA, Aguado Martínez A, Lamaze C, Martínez-A C, Fischer T
Cell Signal. 2009
PubMed ID: 19643177
A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex.
Li X, MacLeod R, Dunlop AJ, Edwards HV, Advant N, Gibson LC, Devine NM, Brown KM, Adams DR, Houslay MD, Baillie GS
FEBS Lett. 2009
PubMed ID: 19782076
A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.
Gesty-Palmer D, Flannery P, Yuan L, Corsino L, Spurney R, Lefkowitz RJ, Luttrell LM
Sci Transl Med. 2009
PubMed ID: 20368153
Imaging ligand-dependent activation of CXCR7.
Luker KE, Gupta M, Steele JM, Foerster BR, Luker GD
Neoplasia. 2009
PubMed ID: 19794961
An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages.
Cheung R, Malik M, Ravyn V, Tomkowicz B, Ptasznik A, Collman RG
J Leukoc Biol. 2009
PubMed ID: 19620252
Beta-arrestin2 regulates parathyroid hormone effects on a p38 MAPK and NFkappaB gene expression network in osteoblasts.
Bianchi EN, Ferrari SL
Bone. 2009
PubMed ID: 19560570
Vascular hyporesponsiveness to angiotensin II in rats with CCl(4)-induced liver cirrhosis.
Hennenberg M, Trebicka J, Kohistani AZ, Heller J, Sauerbruch T
Eur J Clin Invest. 2009
PubMed ID: 19522833
The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, Pita G, Milne R, Maravall J, Ramos I, Andía V, Rodríguez-Poyo P, Jara-Albarrán A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Picó A, Pomares F, Giménez G, López-Mondéjar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodríguez-Antona C, González-Neira A, Matías-Guiu X, Santisteban P, Robledo M
PLoS Genet. 2009
PubMed ID: 19730683
Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling.
Cottrell GS, Padilla BE, Amadesi S, Poole DP, Murphy JE, Hardt M, Roosterman D, Steinhoff M, Bunnett NW
J Biol Chem. 2009
PubMed ID: 19531493
HIV-1 gp120 primes lymphocytes for opioid-induced, beta-arrestin 2-dependent apoptosis.
Moorman J, Zhang Y, Liu B, LeSage G, Chen Y, Stuart C, Prayther D, Yin D
Biochim Biophys Acta. 2009
PubMed ID: 19477204
The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2.
You HJ, How T, Blobe GC
Carcinogenesis. 2009
PubMed ID: 19325136
Beta-arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation.
Molteni R, Crespo CL, Feigelson S, Moser C, Fabbri M, Grabovsky V, Krombach F, Laudanna C, Alon R, Pardi R
Blood. 2009
PubMed ID: 19429870
Arrestin3 mediates D(2) dopamine receptor internalization.
Skinbjerg M, Ariano MA, Thorsell A, Heilig M, Halldin C, Innis RB, Sibley DR
Synapse. 2009
PubMed ID: 19309759
beta-Arrestins facilitate ubiquitin-dependent degradation of apoptosis signal-regulating kinase 1 (ASK1) and attenuate H2O2-induced apoptosis.
Zhang Z, Hao J, Zhao Z, Ben P, Fang F, Shi L, Gao Y, Liu J, Wen C, Luo L, Yin Z
Cell Signal. 2009
PubMed ID: 19306926
The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.
Berthouze M, Venkataramanan V, Li Y, Shenoy SK
EMBO J. 2009
PubMed ID: 19424180
Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5.
Li X, Baillie GS, Houslay MD
J Biol Chem. 2009
PubMed ID: 19372219
Identification of betaArrestin2 as a corepressor of androgen receptor signaling in prostate cancer.
Lakshmikanthan V, Zou L, Kim JI, Michal A, Nie Z, Messias NC, Benovic JL, Daaka Y
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19458261
Nicotine sensitization and analysis of brain-derived neurotrophic factor in adolescent beta-arrestin-2 knockout mice.
Correll JA, Noel DM, Sheppard AB, Thompson KN, Li Y, Yin D, Brown RW
Synapse. 2009
PubMed ID: 19224602
Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression.
David DJ, Samuels BA, Rainer Q, Wang JW, Marsteller D, Mendez I, Drew M, Craig DA, Guiard BP, Guilloux JP, Artymyshyn RP, Gardier AM, Gerald C, Antonijevic IA, Leonardo ED, Hen R
Neuron. 2009
PubMed ID: 19477151
A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, for the MrOS Research Group
J Bone Miner Res. 2009
PubMed ID: 19453261
The type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrestin2-mediated activation of Cdc42.
Mythreye K, Blobe GC
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19416857
Molecular mechanisms involved in activity of h7C10, a humanized monoclonal antibody, to IGF-1 receptor.
Broussas M, Dupont J, Gonzalez A, Blaecke A, Fournier M, Corvaïa N, Goetsch L
Int J Cancer. 2009
PubMed ID: 19165858
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.
Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ
J Clin Invest. 2009
PubMed ID: 19349687
Prolonged RXFP1 and RXFP2 signaling can be explained by poor internalization and a lack of beta-arrestin recruitment.
Callander GE, Thomas WG, Bathgate RA
Am J Physiol Cell Physiol. 2009
PubMed ID: 19279230
Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor.
Kim J, Ahn S, Rajagopal K, Lefkowitz RJ
J Biol Chem. 2009
PubMed ID: 19254952
GRK mythology: G-protein receptor kinases in cardiovascular disease.
Dorn GW
J Mol Med (Berl). 2009
PubMed ID: 19229505
NHERF1 regulates parathyroid hormone receptor desensitization: interference with beta-arrestin binding.
Wang B, Yang Y, Abou-Samra AB, Friedman PA
Mol Pharmacol. 2009
PubMed ID: 19188335
Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice.
Pierroz DD, Rufo A, Bianchi EN, Glatt V, Capulli M, Rucci N, Cavat F, Rizzoli R, Teti A, Bouxsein ML, Ferrari SL
J Bone Miner Res. 2009
PubMed ID: 19113915
Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.
Shenoy SK, Modi AS, Shukla AK, Xiao K, Berthouze M, Ahn S, Wilkinson KD, Miller WE, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19363159
{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation.
Ahn S, Kim J, Hara MR, Ren XR, Lefkowitz RJ
J Biol Chem. 2009
PubMed ID: 19171933
Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neurons.
Dang VC, Napier IA, Christie MJ
J Neurosci. 2009
PubMed ID: 19279269
p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neurons.
Tan M, Walwyn WM, Evans CJ, Xie CW
J Biol Chem. 2009
PubMed ID: 19126537
Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.
Luan B, Zhao J, Wu H, Duan B, Shu G, Wang X, Li D, Jia W, Kang J, Pei G
Nature. 2009
PubMed ID: 19122674
Genetic association studies of methamphetamine use disorders: A systematic review and synthesis.
Bousman CA, Glatt SJ, Everall IP, Tsuang MT
Am J Med Genet B Neuropsychiatr Genet. 2009
PubMed ID: 19219857
Hematopoietic protein tyrosine phosphatase mediates beta2-adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytes.
McAlees JW, Sanders VM
Mol Cell Biol. 2009
PubMed ID: 19047375
Morphine promotes apoptosis via TLR2, and this is negatively regulated by beta-arrestin 2.
Li Y, Sun X, Zhang Y, Huang J, Hanley G, Ferslew KE, Peng Y, Yin D
Biochem Biophys Res Commun. 2009
PubMed ID: 19071087
Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons.
Yu YJ, Arttamangkul S, Evans CJ, Williams JT, von Zastrow M
J Neurosci. 2009
PubMed ID: 19129399
Genetical genomic determinants of alcohol consumption in rats and humans.
Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL, WHO/ISBRA Study on State and Trait Markers of Alcoholism
BMC Biol. 2009
PubMed ID: 19874574
beta-arrestin2 inhibits opioid-induced breast cancer cell death through Akt and caspase-8 pathways.
Zhao M, Zhou G, Zhang Y, Chen T, Sun X, Stuart C, Hanley G, Li J, Zhang J, Yin D
Neoplasma. 2009
PubMed ID: 19239323
Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades.
Chen J, Rusnak M, Lombroso PJ, Sidhu A
Eur J Neurosci. 2009
PubMed ID: 19200235
Roles of G protein and beta-arrestin in dopamine D2 receptor-mediated ERK activation.
Quan W, Kim JH, Albert PR, Choi H, Kim KM
Biochem Biophys Res Commun. 2008
PubMed ID: 18940181
The coding-synonymous polymorphism rs1045280 (Ser280Ser) in beta-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia.
Liou YJ, Wang YC, Chen JY, Chen ML, Chen TT, Bai YM, Lin CC, Liao DL, Lai IC
Eur J Neurol. 2008
PubMed ID: 19049562
Dual role of the beta2-adrenergic receptor C terminus for the binding of beta-arrestin and receptor internalization.
Krasel C, Zabel U, Lorenz K, Reiner S, Al-Sabah S, Lohse MJ
J Biol Chem. 2008
PubMed ID: 18801735
Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2.
Hoffmann C, Ziegler N, Reiner S, Krasel C, Lohse MJ
J Biol Chem. 2008
PubMed ID: 18703513
Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling.
Labasque M, Reiter E, Becamel C, Bockaert J, Marin P
Mol Biol Cell. 2008
PubMed ID: 18768750
Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.
Lasky-Su J, Anney RJ, Neale BM, Franke B, Zhou K, Maller JB, Vasquez AA, Chen W, Asherson P, Buitelaar J, Banaschewski T, Ebstein R, Gill M, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen HC, Taylor E, Daly M, Laird N, Lange C, Faraone SV
Am J Med Genet B Neuropsychiatr Genet. 2008
PubMed ID: 18937294
Arrestin 3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21.
Byers MA, Calloway PA, Shannon L, Cunningham HD, Smith S, Li F, Fassold BC, Vines CM
J Immunol. 2008
PubMed ID: 18802075
Differential activation and trafficking of micro-opioid receptors in brain slices.
Arttamangkul S, Quillinan N, Low MJ, von Zastrow M, Pintar J, Williams JT
Mol Pharmacol. 2008
PubMed ID: 18612077
Nuclear beta-arrestin1 functions as a scaffold for the dephosphorylation of STAT1 and moderates the antiviral activity of IFN-gamma.
Mo W, Zhang L, Yang G, Zhai J, Hu Z, Chen Y, Chen X, Hui L, Huang R, Hu G
Mol Cell. 2008
PubMed ID: 18775329
Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50.
Stanasila L, Abuin L, Dey J, Cotecchia S
Mol Pharmacol. 2008
PubMed ID: 18523139
S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking.
Ozawa K, Whalen EJ, Nelson CD, Mu Y, Hess DT, Lefkowitz RJ, Stamler JS
Mol Cell. 2008
PubMed ID: 18691971
Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor.
Shenoy SK, Xiao K, Venkataramanan V, Snyder PM, Freedman NJ, Weissman AM
J Biol Chem. 2008
PubMed ID: 18544533
An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.
Yu MC, Su LL, Zou L, Liu Y, Wu N, Kong L, Zhuang ZH, Sun L, Liu HP, Hu JH, Li D, Strominger JL, Zang JW, Pei G, Ge BX
Nat Immunol. 2008
PubMed ID: 18604210
Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.
Shukla AK, Violin JD, Whalen EJ, Gesty-Palmer D, Shenoy SK, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18621717
Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration.
Kim J, Zhang L, Peppel K, Wu JH, Zidar DA, Brian L, DeWire SM, Exum ST, Lefkowitz RJ, Freedman NJ
Circ Res. 2008
PubMed ID: 18519945
Sensitivity to delta9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2 -/- mice.
Breivogel CS, Lambert JM, Gerfin S, Huffman JW, Razdan RK
Behav Pharmacol. 2008
PubMed ID: 18622177
Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs.
Xu TR, Baillie GS, Bhari N, Houslay TM, Pitt AM, Adams DR, Kolch W, Houslay MD, Milligan G
Biochem J. 2008
PubMed ID: 18435604
Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms.
Zhang X, Wang F, Chen X, Chen Y, Ma L
J Neurochem. 2008
PubMed ID: 18419762
Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle.
Deshpande DA, Theriot BS, Penn RB, Walker JK
FASEB J. 2008
PubMed ID: 18337459
Beta2-adrenergic receptor regulates Toll-like receptor-4-induced nuclear factor-kappaB activation through beta-arrestin 2.
Kizaki T, Izawa T, Sakurai T, Haga S, Taniguchi N, Tajiri H, Watanabe K, Day NK, Toba K, Ohno H
Immunology. 2008
PubMed ID: 18194271
Beta-arrestin-mediated localization of smoothened to the primary cilium.
Kovacs JJ, Whalen EJ, Liu R, Xiao K, Kim J, Chen M, Wang J, Chen W, Lefkowitz RJ
Science. 2008
PubMed ID: 18497258
The beta-arrestin-2 scaffold protein promotes c-Jun N-terminal kinase-3 activation by binding to its nonconserved N terminus.
Guo C, Whitmarsh AJ
J Biol Chem. 2008
PubMed ID: 18408005
Depletion of beta-arrestin-2 promotes tumor growth and angiogenesis in a murine model of lung cancer.
Raghuwanshi SK, Nasser MW, Chen X, Strieter RM, Richardson RM
J Immunol. 2008
PubMed ID: 18390755
Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages.
Loniewski K, Shi Y, Pestka J, Parameswaran N
Mol Immunol. 2008
PubMed ID: 18180038
Beta-arrestins 1 and 2 are associated with nicotine dependence in European American smokers.
Sun D, Ma JZ, Payne TJ, Li MD
Mol Psychiatry. 2008
PubMed ID: 17579607
Modulation of voluntary ethanol consumption by beta-arrestin 2.
Björk K, Rimondini R, Hansson AC, Terasmaa A, Hyyti P, Heilig M, Sommer WH
FASEB J. 2008
PubMed ID: 18367649
Beta-arrestins: multifunctional cellular mediators.
Barki-Harrington L, Rockman HA
Physiology (Bethesda). 2008
PubMed ID: 18268361
Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction.
Kim KM, Caron MG
Biochem Biophys Res Commun. 2008
PubMed ID: 18036556
Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription.
Lee MH, El-Shewy HM, Luttrell DK, Luttrell LM
J Biol Chem. 2008
PubMed ID: 18006496
Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo.
Schmid CL, Raehal KM, Bohn LM
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18195357
A beta-arrestin 2 signaling complex mediates lithium action on behavior.
Beaulieu JM, Marion S, Rodriguiz RM, Medvedev IO, Sotnikova TD, Ghisi V, Wetsel WC, Lefkowitz RJ, Gainetdinov RR, Caron MG
Cell. 2008
PubMed ID: 18191226
Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control.
Molla-Herman A, Boularan C, Ghossoub R, Scott MG, Burtey A, Zarka M, Saunier S, Concordet JP, Marullo S, Benmerah A
PLoS ONE. 2008
PubMed ID: 19008961
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
Ballif BA, Carey GR, Sunyaev SR, Gygi SP
J Proteome Res. 2008
PubMed ID: 18034455
Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4.
Bhandari D, Trejo J, Benovic JL, Marchese A
J Biol Chem. 2007
PubMed ID: 17947233
Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins.
Padilla BE, Cottrell GS, Roosterman D, Pikios S, Muller L, Steinhoff M, Bunnett NW
J Cell Biol. 2007
PubMed ID: 18039931
Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110 alpha and beta by protease-activated receptor 2 and beta-arrestins.
Wang P, Kumar P, Wang C, Defea KA
Biochem J. 2007
PubMed ID: 17680774
beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53.
Boularan C, Scott MG, Bourougaa K, Bellal M, Esteve E, Thuret A, Benmerah A, Tramier M, Coppey-Moisan M, Labbé-Jullié C, Fåhraeus R, Marullo S
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17984062
Genetic variation in mu-opioid-receptor-interacting proteins and smoking cessation in a nicotine replacement therapy trial.
Ray R, Jepson C, Wileyto EP, Dahl JP, Patterson F, Rukstalis M, Pinto A, Berrettini W, Lerman C
Nicotine Tob Res. 2007
PubMed ID: 17978999
Evidence for a role of caveolin-1 in neurokinin-1 receptor plasma-membrane localization, efficient signaling, and interaction with beta-arrestin 2.
Kubale V, Abramović Z, Pogacnik A, Heding A, Sentjurc M, Vrecl M
Cell Tissue Res. 2007
PubMed ID: 17713785
Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.
Shenoy SK, Barak LS, Xiao K, Ahn S, Berthouze M, Shukla AK, Luttrell LM, Lefkowitz RJ
J Biol Chem. 2007
PubMed ID: 17666399
Promoter polymorphism and expression of beta-arrestin 2 in neutrophils.
Zhang X, He JQ, Ding L, Paré PD, Sandford AJ
Clin Chim Acta. 2007
PubMed ID: 17761157
The role of beta-arrestins in the formyl peptide receptor-like 1 internalization and signaling.
Huet E, Boulay F, Barral S, Rabiet MJ
Cell Signal. 2007
PubMed ID: 17594911
Phosphorylation of the delta-opioid receptor regulates its beta-arrestins selectivity and subsequent receptor internalization and adenylyl cyclase desensitization.
Qiu Y, Loh HH, Law PY
J Biol Chem. 2007
PubMed ID: 17565992
Critical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1.
Shi Y, Feng Y, Kang J, Liu C, Li Z, Li D, Cao W, Qiu J, Guo Z, Bi E, Zang L, Lu C, Zhang JZ, Pei G
Nat Immunol. 2007
PubMed ID: 17618287
Beta-arrestin-dependent parathyroid hormone-stimulated extracellular signal-regulated kinase activation and parathyroid hormone type 1 receptor internalization.
Sneddon WB, Friedman PA
Endocrinology. 2007
PubMed ID: 17525124
The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells.
Lee NY, Blobe GC
J Biol Chem. 2007
PubMed ID: 17540773
The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2.
Nobles KN, Guan Z, Xiao K, Oas TG, Lefkowitz RJ
J Biol Chem. 2007
PubMed ID: 17513300
Functional specialization of beta-arrestin interactions revealed by proteomic analysis.
Xiao K, McClatchy DB, Shukla AK, Zhao Y, Chen M, Shenoy SK, Yates JR, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17620599
Differential effects of beta-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2.
Kumar P, Lau CS, Mathur M, Wang P, DeFea KA
Am J Physiol Cell Physiol. 2007
PubMed ID: 17442737
N-terminal tyrosine modulation of the endocytic adaptor function of the beta-arrestins.
Marion S, Fralish GB, Laporte S, Caron MG, Barak LS
J Biol Chem. 2007
PubMed ID: 17456469
5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling.
Barthet G, Framery B, Gaven F, Pellissier L, Reiter E, Claeysen S, Bockaert J, Dumuis A
Mol Biol Cell. 2007
PubMed ID: 17377064
Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons.
Walwyn W, Evans CJ, Hales TG
J Neurosci. 2007
PubMed ID: 17494695
Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression.
Fan H, Luttrell LM, Tempel GE, Senn JJ, Halushka PV, Cook JA
Mol Immunol. 2007
PubMed ID: 17418896
Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo.
Bryja V, Gradl D, Schambony A, Arenas E, Schulte G
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17426148
Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins.
Nelson CD, Perry SJ, Regier DS, Prescott SM, Topham MK, Lefkowitz RJ
Science. 2007
PubMed ID: 17272726
Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins.
Hennenberg M, Trebicka J, Biecker E, Schepke M, Sauerbruch T, Heller J
Hepatology. 2007
PubMed ID: 17256744
Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia.
Ikeda M, Ozaki N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Kishi T, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada T, Iwata N
Genes Brain Behav. 2007
PubMed ID: 17233643
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation.
Rey A, Manen D, Rizzoli R, Caverzasio J, Ferrari SL
J Biol Chem. 2006
PubMed ID: 17038311
Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages.
Parameswaran N, Pao CS, Leonhard KS, Kang DS, Kratz M, Ley SC, Benovic JL
J Biol Chem. 2006
PubMed ID: 16980301
VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin.
Gavard J, Gutkind JS
Nat Cell Biol. 2006
PubMed ID: 17060906
Opposing effects of beta-arrestin1 and beta-arrestin2 on activation and degradation of Src induced by protease-activated receptor 1.
Kuo FT, Lu TL, Fu HW
Cell Signal. 2006
PubMed ID: 16580177
Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.
Rajagopal K, Whalen EJ, Violin JD, Stiber JA, Rosenberg PB, Premont RT, Coffman TM, Rockman HA, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17060617
The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.
Brookes K, Xu X, Chen W, Zhou K, Neale B, Lowe N, Anney R, Aneey R, Franke B, Gill M, Ebstein R, Buitelaar J, Sham P, Campbell D, Knight J, Andreou P, Altink M, Arnold R, Boer F, Buschgens C, Butler L, Christiansen H, Feldman L, Fleischman K, Fliers E, Howe-Forbes R, Goldfarb A, Heise A, Gabriëls I, Korn-Lubetzki I, Johansson L, Marco R, Medad S, Minderaa R, Mulas F, Müller U, Mulligan A, Rabin K, Rommelse N, Sethna V, Sorohan J, Uebel H, Psychogiou L, Weeks A, Barrett R, Craig I, Banaschewski T, Sonuga-Barke E, Eisenberg J, Kuntsi J, Manor I, McGuffin P, Miranda A, Oades RD, Plomin R, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Taylor E, Thompson M, Faraone SV, Asherson P
Mol Psychiatry. 2006
PubMed ID: 16894395
Beta-arrestin2-mediated internalization of mammalian odorant receptors.
Mashukova A, Spehr M, Hatt H, Neuhaus EM
J Neurosci. 2006
PubMed ID: 17005854
beta-Arrestin2 mediates nephrin endocytosis and impairs slit diaphragm integrity.
Quack I, Rump LC, Gerke P, Walther I, Vinke T, Vonend O, Grunwald T, Sellin L
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16968782
Arrestin serves as a molecular switch, linking endogenous alpha2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activation.
Wang Q, Lu R, Zhao J, Limbird LE
J Biol Chem. 2006
PubMed ID: 16809338
Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.
Bolger GB, Baillie GS, Li X, Lynch MJ, Herzyk P, Mohamed A, Mitchell LH, McCahill A, Hundsrucker C, Klussmann E, Adams DR, Houslay MD
Biochem J. 2006
PubMed ID: 16689683
Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets.
Hauger RL, Risbrough V, Brauns O, Dautzenberg FM
CNS Neurol Disord Drug Targets. 2006
PubMed ID: 16918397
G protein-coupled receptor kinase 2 and beta-arrestins are recruited to FSH receptor in stimulated rat primary Sertoli cells.
Marion S, Kara E, Crepieux P, Piketty V, Martinat N, Guillou F, Reiter E
J Endocrinol. 2006
PubMed ID: 16899567
Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.
Neuhaus EM, Mashukova A, Barbour J, Wolters D, Hatt H
J Cell Sci. 2006
PubMed ID: 16820410
The human thyrotropin receptor is predominantly internalized by beta-arrestin 2.
Frenzel R, Voigt C, Paschke R
Endocrinology. 2006
PubMed ID: 16513835
Cooperative regulation of extracellular signal-regulated kinase activation and cell shape change by filamin A and beta-arrestins.
Scott MG, Pierotti V, Storez H, Lindberg E, Thuret A, Muntaner O, Labbé-Jullié C, Pitcher JA, Marullo S
Mol Cell Biol. 2006
PubMed ID: 16611986
Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
Gesty-Palmer D, Chen M, Reiter E, Ahn S, Nelson CD, Wang S, Eckhardt AE, Cowan CL, Spurney RF, Luttrell LM, Lefkowitz RJ
J Biol Chem. 2006
PubMed ID: 16492667
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C
Nature. 2006
PubMed ID: 16625196
Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment.
Small KM, Schwarb MR, Glinka C, Theiss CT, Brown KM, Seman CA, Liggett SB
Biochemistry. 2006
PubMed ID: 16605244
The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor.
Innamorati G, Piccirillo R, Bagnato P, Palmisano I, Schiaffino MV
Pigment Cell Res. 2006
PubMed ID: 16524428
Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.
Edeling MA, Mishra SK, Keyel PA, Steinhauser AL, Collins BM, Roth R, Heuser JE, Owen DJ, Traub LM
Dev Cell. 2006
PubMed ID: 16516836
A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors.
Marion S, Oakley RH, Kim KM, Caron MG, Barak LS
J Biol Chem. 2006
PubMed ID: 16319069
Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.
Wang Y, Tang Y, Teng L, Wu Y, Zhao X, Pei G
Nat Immunol. 2006
PubMed ID: 16378096
Beta-adrenergic receptor trafficking by exercise in rat adipocytes: roles of G-protein-coupled receptor kinase-2, beta-arrestin-2, and the ubiquitin-proteasome pathway.
Ogasawara J, Sanpei M, Rahman N, Sakurai T, Kizaki T, Hitomi Y, Ohno H, Izawa T
FASEB J. 2006
PubMed ID: 16368719
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
Shenoy SK, Drake MT, Nelson CD, Houtz DA, Xiao K, Madabushi S, Reiter E, Premont RT, Lichtarge O, Lefkowitz RJ
J Biol Chem. 2006
PubMed ID: 16280323
Beta-arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-kappaB activation.
Luan B, Zhang Z, Wu Y, Kang J, Pei G
EMBO J. 2005
PubMed ID: 16308565
A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription.
Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, Yang R, Fan F, Chen X, Pei G, Ma L
Cell. 2005
PubMed ID: 16325578
Angiotensin II-stimulated signaling through G proteins and beta-arrestin.
Shenoy SK, Lefkowitz RJ
Sci STKE. 2005
PubMed ID: 16304060
A requirement for membrane cholesterol in the beta-arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors.
Urs NM, Jones KT, Salo PD, Severin JE, Trejo J, Radhakrishna H
J Cell Sci. 2005
PubMed ID: 16263766
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
Hüttenrauch F, Pollok-Kopp B, Oppermann M
J Biol Chem. 2005
PubMed ID: 16144840
Altered CXCR2 signaling in beta-arrestin-2-deficient mouse models.
Su Y, Raghuwanshi SK, Yu Y, Nanney LB, Richardson RM, Richmond A
J Immunol. 2005
PubMed ID: 16210646
Beta-arrestin1 and beta-arrestin2 are differentially required for phosphorylation-dependent and -independent internalization of delta-opioid receptors.
Zhang X, Wang F, Chen X, Li J, Xiang B, Zhang YQ, Li BM, Ma L
J Neurochem. 2005
PubMed ID: 16181421
Beta-arrestin2 enhances beta2-adrenergic receptor-mediated nuclear translocation of ERK.
Kobayashi H, Narita Y, Nishida M, Kurose H
Cell Signal. 2005
PubMed ID: 16038799
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.
Gesty-Palmer D, El Shewy H, Kohout TA, Luttrell LM
J Biol Chem. 2005
PubMed ID: 16027114
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons.
Haberstock-Debic H, Kim KA, Yu YJ, von Zastrow M
J Neurosci. 2005
PubMed ID: 16120787
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG
Cell. 2005
PubMed ID: 16051150
Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2.
Willoughby EA, Collins MK
J Biol Chem. 2005
PubMed ID: 15888437
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.
Girnita L, Shenoy SK, Sehat B, Vasilcanu R, Girnita A, Lefkowitz RJ, Larsson O
J Biol Chem. 2005
PubMed ID: 15878855
The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation.
Estall JL, Koehler JA, Yusta B, Drucker DJ
J Biol Chem. 2005
PubMed ID: 15817468
ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor.
Feng YH, Wang L, Wang Q, Li X, Zeng R, Gorodeski GI
Am J Physiol Cell Physiol. 2005
PubMed ID: 15728711
Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.
Shenoy SK, Lefkowitz RJ
J Biol Chem. 2005
PubMed ID: 15699045
beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice.
Bouxsein ML, Pierroz DD, Glatt V, Goddard DS, Cavat F, Rizzoli R, Ferrari SL
J Bone Miner Res. 2005
PubMed ID: 15765183
Bone response to intermittent parathyroid hormone is altered in mice null for {beta}-Arrestin2.
Ferrari SL, Pierroz DD, Glatt V, Goddard DS, Bianchi EN, Lin FT, Manen D, Bouxsein ML
Endocrinology. 2005
PubMed ID: 15705780
G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation.
Kim KM, Gainetdinov RR, Laporte SA, Caron MG, Barak LS
J Biol Chem. 2005
PubMed ID: 15687500
Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.
Pi M, Oakley RH, Gesty-Palmer D, Cruickshank RD, Spurney RF, Luttrell LM, Quarles LD
Mol Endocrinol. 2005
PubMed ID: 15637145
Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis.
Hunton DL, Barnes WG, Kim J, Ren XR, Violin JD, Reiter E, Milligan G, Patel DD, Lefkowitz RJ
Mol Pharmacol. 2005
PubMed ID: 15635042
Beta-arrestin-dependent spontaneous alpha1a-adrenoceptor endocytosis causes intracellular transportation of alpha-blockers via recycling compartments.
Pediani JD, Colston JF, Caldwell D, Milligan G, Daly CJ, McGrath JC
Mol Pharmacol. 2005
PubMed ID: 15626751
Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment.
Hack SP, Bagley EE, Chieng BC, Christie MJ
J Neurosci. 2005
PubMed ID: 15788776
Beta-arrestin binding to the beta2-adrenergic receptor requires both receptor phosphorylation and receptor activation.
Krasel C, Bünemann M, Lorenz K, Lohse MJ
J Biol Chem. 2005
PubMed ID: 15634674
beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.
Barnes WG, Reiter E, Violin JD, Ren XR, Milligan G, Lefkowitz RJ
J Biol Chem. 2005
PubMed ID: 15611106
Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype.
Jorgensen R, Martini L, Schwartz TW, Elling CE
Mol Endocrinol. 2005
PubMed ID: 15528268
beta-Arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioids.
Bradaïa A, Berton F, Ferrari S, Lüscher C
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15718284
beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform.
Szabó EZ, Numata M, Lukashova V, Iannuzzi P, Orlowski J
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15699339
Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.
Ren XR, Reiter E, Ahn S, Kim J, Chen W, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15671180
c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during clathrin- mediated internalization.
Fessart D, Simaan M, Laporte SA
Mol Endocrinol. 2005
PubMed ID: 15498833
Clinical response to morphine in cancer patients and genetic variation in candidate genes.
Ross JR, Rutter D, Welsh K, Joel SP, Goller K, Wells AU, Du Bois R, Riley J
Pharmacogenomics J. 2005
PubMed ID: 16103897
Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking.
Stalheim L, Ding Y, Gullapalli A, Paing MM, Wolfe BL, Morris DR, Trejo J
Mol Pharmacol. 2005
PubMed ID: 15475570
Activation-dependent conformational changes in {beta}-arrestin 2.
Xiao K, Shenoy SK, Nobles K, Lefkowitz RJ
J Biol Chem. 2004
PubMed ID: 15501822
Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2.
Ge L, Shenoy SK, Lefkowitz RJ, DeFea K
J Biol Chem. 2004
PubMed ID: 15489220
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.
Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ
Science. 2004
PubMed ID: 15618519
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Real-time monitoring of ubiquitination in living cells by BRET.
Perroy J, Pontier S, Charest PG, Aubry M, Bouvier M
Nat Methods. 2004
PubMed ID: 15782195
Preferential Interaction between the dopamine D2 receptor and Arrestin2 in neostriatal neurons.
Macey TA, Gurevich VV, Neve KA
Mol Pharmacol. 2004
PubMed ID: 15361545
Arrestin regulates MAPK activation and prevents NADPH oxidase-dependent death of cells expressing CXCR2.
Zhao M, Wimmer A, Trieu K, Discipio RG, Schraufstatter IU
J Biol Chem. 2004
PubMed ID: 15364949
Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2.
Wei H, Ahn S, Barnes WG, Lefkowitz RJ
J Biol Chem. 2004
PubMed ID: 15355986
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor.
Ahn S, Shenoy SK, Wei H, Lefkowitz RJ
J Biol Chem. 2004
PubMed ID: 15205453
Functional proteomics mapping of a human signaling pathway.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM
Genome Res. 2004
PubMed ID: 15231748
Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.
Wang Q, Zhao J, Brady AE, Feng J, Allen PB, Lefkowitz RJ, Greengard P, Limbird LE
Science. 2004
PubMed ID: 15218143
beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.
Witherow DS, Garrison TR, Miller WE, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15173580
Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7.
Kohout TA, Nicholas SL, Perry SJ, Reinhart G, Junger S, Struthers RS
J Biol Chem. 2004
PubMed ID: 15054093
Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways.
Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B, Pei G
Mol Cell. 2004
PubMed ID: 15125834
Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77.
Castro-Obregón S, Rao RV, del Rio G, Chen SF, Poksay KS, Rabizadeh S, Vesce S, Zhang XK, Swanson RA, Bredesen DE
J Biol Chem. 2004
PubMed ID: 14769794
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.
Ahn S, Wei H, Garrison TR, Lefkowitz RJ
J Biol Chem. 2004
PubMed ID: 14711824
Delayed expression of the Crx gene and photoreceptor development in the Chx10-deficient retina.
Rutherford AD, Dhomen N, Smith HK, Sowden JC
Invest Ophthalmol Vis Sci. 2004
PubMed ID: 14744875
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins.
Bolger GB, McCahill A, Huston E, Cheung YF, McSorley T, Baillie GS, Houslay MD
J Biol Chem. 2003
PubMed ID: 14500724
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice.
Bohn LM, Gainetdinov RR, Sotnikova TD, Medvedev IO, Lefkowitz RJ, Dykstra LA, Caron MG
J Neurosci. 2003
PubMed ID: 14614085
The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor.
Wu JH, Peppel K, Nelson CD, Lin FT, Kohout TA, Miller WE, Exum ST, Freedman NJ
J Biol Chem. 2003
PubMed ID: 12944399
N-formyl peptide receptors internalize but do not recycle in the absence of arrestins.
Vines CM, Revankar CM, Maestas DC, LaRusch LL, Cimino DF, Kohout TA, Lefkowitz RJ, Prossnitz ER
J Biol Chem. 2003
PubMed ID: 12947104
The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins.
Schmidlin F, Roosterman D, Bunnett NW
Am J Physiol Cell Physiol. 2003
PubMed ID: 12958028
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.
Wei H, Ahn S, Shenoy SK, Karnik SS, Hunyady L, Luttrell LM, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12949261
Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling.
Chen W, Kirkbride KC, How T, Nelson CD, Mo J, Frederick JP, Wang XF, Lefkowitz RJ, Blobe GC
Science. 2003
PubMed ID: 12958365
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ
Science. 2003
PubMed ID: 12958364
Beta-arrestin-2 regulates the development of allergic asthma.
Walker JK, Fong AM, Lawson BL, Savov JD, Patel DD, Schwartz DA, Lefkowitz RJ
J Clin Invest. 2003
PubMed ID: 12925697
Loss of intracellular dystrophin: a potential mechanism for myocardial reperfusion injury.
Kyoi S, Otani H, Sumida T, Okada T, Osako M, Imamura H, Kamihata H, Matsubara H, Iwasaka T
Circ J. 2003
PubMed ID: 12890920
A G protein-coupled receptor kinase induces Xenopus oocyte maturation.
Wang J, Liu XJ
J Biol Chem. 2003
PubMed ID: 12600992
Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination.
Shenoy SK, Lefkowitz RJ
J Biol Chem. 2003
PubMed ID: 12574160
Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus.
Wang P, Wu Y, Ge X, Ma L, Pei G
J Biol Chem. 2003
PubMed ID: 12538596
Regulation of GRK 2 and 6, beta-arrestin-2 and associated proteins in the prefrontal cortex of drug-free and antidepressant drug-treated subjects with major depression.
Grange-Midroit M, García-Sevilla JA, Ferrer-Alcón M, La Harpe R, Huguelet P, Guimón J
Brain Res Mol Brain Res. 2003
PubMed ID: 12654503
Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2.
Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L, Pei G
J Biol Chem. 2003
PubMed ID: 12488444
The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.
Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, Luttrell LM
J Biol Chem. 2003
PubMed ID: 12473660
Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference.
Ahn S, Nelson CD, Garrison TR, Miller WE, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12582207
Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway.
Braun L, Christophe T, Boulay F
J Biol Chem. 2003
PubMed ID: 12464600
Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.
Hanyaloglu AC, Seeber RM, Kohout TA, Lefkowitz RJ, Eidne KA
J Biol Chem. 2002
PubMed ID: 12393857
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation.
Sun Y, Cheng Z, Ma L, Pei G
J Biol Chem. 2002
PubMed ID: 12370187
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.
Bohn LM, Lefkowitz RJ, Caron MG
J Neurosci. 2002
PubMed ID: 12451149
Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
Perry SJ, Baillie GS, Kohout TA, McPhee I, Magiera MM, Ang KL, Miller WE, McLean AJ, Conti M, Houslay MD, Lefkowitz RJ
Science. 2002
PubMed ID: 12399592
Differential nucleocytoplasmic shuttling of beta-arrestins. Characterization of a leucine-rich nuclear export signal in beta-arrestin2.
Scott MG, Le Rouzic E, Périanin A, Pierotti V, Enslen H, Benichou S, Marullo S, Benmerah A
J Biol Chem. 2002
PubMed ID: 12167659
Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors.
Lin FT, Chen W, Shenoy S, Cong M, Exum ST, Lefkowitz RJ
Biochemistry. 2002
PubMed ID: 12186555
Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein-coupled receptor trafficking.
Kim YM, Benovic JL
J Biol Chem. 2002
PubMed ID: 12070169
Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization.
Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SS
Nat Cell Biol. 2002
PubMed ID: 12105416
Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.
Fong AM, Premont RT, Richardson RM, Yu YR, Lefkowitz RJ, Patel DD
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12032308
Aspartic acid 564 in the third cytoplasmic loop of the luteinizing hormone/choriogonadotropin receptor is crucial for phosphorylation-independent interaction with arrestin2.
Mukherjee S, Gurevich VV, Preninger A, Hamm HE, Bader MF, Fazleabas AT, Birnbaumer L, Hunzicker-Dunn M
J Biol Chem. 2002
PubMed ID: 11867621
Regulation of arrestin-3 phosphorylation by casein kinase II.
Kim YM, Barak LS, Caron MG, Benovic JL
J Biol Chem. 2002
PubMed ID: 11877451
Agonist-induced internalization of the platelet-activating factor receptor is dependent on arrestins but independent of G-protein activation. Role of the C terminus and the (D/N)PXXY motif.
Chen Z, Dupré DJ, Le Gouill C, Rola-Pleszczynski M, Stanková J
J Biol Chem. 2002
PubMed ID: 11729201
Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development.
Gurevich EV, Benovic JL, Gurevich VV
Neuroscience. 2002
PubMed ID: 11823056
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.
Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ
Science. 2001
PubMed ID: 11588219
Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin.
Hilairet S, Bélanger C, Bertrand J, Laperrière A, Foord SM, Bouvier M
J Biol Chem. 2001
PubMed ID: 11535606
beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis.
Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ
J Biol Chem. 2001
PubMed ID: 11533043
Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3.
Miller WE, McDonald PH, Cai SF, Field ME, Davis RJ, Lefkowitz RJ
J Biol Chem. 2001
PubMed ID: 11356842
Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.
Oakley RH, Laporte SA, Holt JA, Barak LS, Caron MG
J Biol Chem. 2001
PubMed ID: 11279203
Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor.
Cen B, Yu Q, Guo J, Wu Y, Ling K, Cheng Z, Ma L, Pei G
J Neurochem. 2001
PubMed ID: 11259507
Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.
Luttrell LM, Roudabush FL, Choy EW, Miller WE, Field ME, Pierce KL, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11226259
The sequence of the human genome.
Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigó R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X
Science. 2001
PubMed ID: 11181995
beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking.
Kohout TA, Lin FS, Perry SJ, Conner DA, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11171997
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.
Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, Caron MG
Nature. 2000
PubMed ID: 11130073
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ
Science. 2000
PubMed ID: 11090355
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI.
Barlic J, Andrews JD, Kelvin AA, Bosinger SE, DeVries ME, Xu L, Dobransky T, Feldman RD, Ferguson SS, Kelvin DJ
Nat Immunol. 2000
PubMed ID: 10973280
Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensitization.
Lin F, Wang H, Malbon CC
J Biol Chem. 2000
PubMed ID: 10858453
Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors.
Oakley RH, Laporte SA, Holt JA, Caron MG, Barak LS
J Biol Chem. 2000
PubMed ID: 10748214
beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4.
Cheng ZJ, Zhao J, Sun Y, Hu W, Wu YL, Cen B, Wu GX, Pei G
J Biol Chem. 2000
PubMed ID: 10644702
Enhanced morphine analgesia in mice lacking beta-arrestin 2.
Bohn LM, Lefkowitz RJ, Gainetdinov RR, Peppel K, Caron MG, Lin FT
Science. 1999
PubMed ID: 10617462
Increased susceptibility to light damage in an arrestin knockout mouse model of Oguchi disease (stationary night blindness)
Chen J, Simon MI, Matthes MT, Yasumura D, LaVail MM
Invest Ophthalmol Vis Sci. 1999
PubMed ID: 10549660
Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin.
Palczewski K, Van Hooser JP, Garwin GG, Chen J, Liou GI, Saari JC
Biochemistry. 1999
PubMed ID: 10508404
The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.
Laporte SA, Oakley RH, Zhang J, Holt JA, Ferguson SS, Caron MG, Barak LS
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10097102
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Differential expression of alternative splice variants of beta-arrestin-1 and -2 in rat central nervous system and peripheral tissues.
Komori N, Cain SD, Roch JM, Miller KE, Matsumoto H
Eur J Neurosci. 1998
PubMed ID: 9767391
G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization.
Lefkowitz RJ
J Biol Chem. 1998
PubMed ID: 9668034
A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation.
Barak LS, Ferguson SS, Zhang J, Caron MG
J Biol Chem. 1997
PubMed ID: 9346876
Prolonged photoresponses in transgenic mouse rods lacking arrestin.
Xu J, Dodd RL, Makino CL, Simon MI, Baylor DA, Chen J
Nature. 1997
PubMed ID: 9333241
Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor.
Le Gouill C, Parent JL, Rola-Pleszczynski M, Stanková J
FEBS Lett. 1997
PubMed ID: 9037196
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively.
Kingsmore SF, Peppel K, Suh D, Caron MG, Lefkowitz RJ, Seldin MF
Mamm Genome. 1995
PubMed ID: 7613043
Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes.
Calabrese G, Sallese M, Stornaiuolo A, Stuppia L, Palka G, De Blasi A
Genomics. 1994
PubMed ID: 7695743
Light-dependent regulation of the transcriptional activity of the mammalian gene for arrestin.
McGinnis JF, Austin BJ, Stepanik PL, Lerious V
J Neurosci Res. 1994
PubMed ID: 7932878
Cone arrestin identified by targeting expression of a functional family.
Craft CM, Whitmore DH, Wiechmann AF
J Biol Chem. 1994
PubMed ID: 8308033
Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing.
Parruti G, Peracchia F, Sallese M, Ambrosini G, Masini M, Rotilio D, De Blasi A
J Biol Chem. 1993
PubMed ID: 8486659
A family of retinal S-antigens (arrestins) and their genes: comparative analysis of human, mouse, rat, bovine and Drosophila.
Shinohara T, Kikuchi T, Tsuda M, Yamaki K
Comp Biochem Physiol B. 1992
PubMed ID: 1458825
Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.
Attramadal H, Arriza JL, Aoki C, Dawson TM, Codina J, Kwatra MM, Snyder SH, Caron MG, Lefkowitz RJ
J Biol Chem. 1992
PubMed ID: 1517224
Cloning of a member of the arrestin family from a human thyroid cDNA library.
Rapoport B, Kaufman KD, Chazenbalk GD
Mol Cell Endocrinol. 1992
PubMed ID: 1587386
Partial purification of a bone-resorbing factor elaborated from human allogeneic cultures.
Horton JE, Koopman WJ, Farrar JJ, Fuller-Bonar J, Mergenhagen SE
Cell Immunol. 1979
PubMed ID: 157224

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	409	216869	25388
EnsEMBL Gene(s)	ENSG00000141480	ENSMUSG00000060216	ENSRNOG00000019308
Unigene	Hs.435811	Mm.203747	Rn.32973
Homologene	ARRB2	Arrb2	Arrb2
OMIM	107941	N/A	N/A
GeneCards	ARRB2	N/A	N/A
Beta Cell Genomics	DT.100029379 DT.100029380 DT.100795649 DT.120918185 DT.120918219 DT.446214 DT.95260335	DT.530327 DT.94333420 DT.97382835 DT.99858083	N/A
Reactome	P32121	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	409	216869	25388

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Interactor	Interactor	Sources	Classification	Pubmed IDs
ARRB2	HIPK3	HPRD, MINT	empirical	15231748
ARRB2	TRIM28	IntAct	empirical	17620599
ARRB2	CDK3	IntAct	empirical	17620599
ARRB2	ALYREF	IntAct	empirical	17620599
ARRB2	CDK4	IntAct	empirical	17620599
ARRB2	CDK7	IntAct	empirical	17620599
ARRB2	HNRNPR	IntAct	empirical	17620599
ARRB2	STUB1	BioGRID	empirical	19306926
ARRB2	TUBB3	IntAct	empirical	17620599
ARRB2	TUBB4A	IntAct	empirical	17620599
ARRB2	TUBB4B	IntAct	empirical	17620599
ARRB2	PRMT5	IntAct	empirical	17620599
ARRB2	TAB1	IntAct	empirical	17620599 20813258
ARRB2	NOP56	IntAct	empirical	17620599
ARRB2	CENPF	IntAct	empirical	17620599
ARRB2	IGF2BP1	IntAct	empirical	17620599
ARRB2	CFL1	IntAct	empirical	17620599 17500066
ARRB2	SPIN1	IntAct	empirical	17620599
ARRB2	HNRNPA0	IntAct	empirical	17620599
ARRB2	YWHAQ	IntAct	empirical	17620599
ARRB2	SF3B2	IntAct	empirical	17620599
ARRB2	RPL35	IntAct	empirical	17620599
ARRB2	CHRM2	IntAct	empirical	19055777
ARRB2	MED8	HPRD, MINT, IntAct, BioGRID	empirical	16169070
ARRB2	STK38	IntAct	empirical	17620599
ARRB2	CHUK	IntAct	empirical	17620599
ARRB2	DCD	IntAct	empirical	17620599
ARRB2	AP2M1	HPRD, BioGRID	empirical	17666399
ARRB2	CLIC1	IntAct	empirical	17620599
ARRB2	CLNS1A	IntAct	empirical	17620599
ARRB2	CLTA	IntAct	empirical	17620599
ARRB2	CLTB	IntAct	empirical	17620599
ARRB2	CLTC	HPRD	empirical	10097102 17666399
ARRB2	CSNK1A1L	IntAct	empirical	17620599
ARRB2	LEO1	IntAct	empirical	17620599
ARRB2	C11orf84	IntAct	empirical	17620599
ARRB2	CSN2	IntAct	empirical	17620599
ARRB2	CSNK2A1	HPRD, IntAct	empirical	11877451 17620599
ARRB2	CSNK2A2	HPRD	empirical	11877451
ARRB2	CTNNA1	IntAct	empirical	17620599
ARRB2	CTNND1	IntAct	empirical	17620599
ARRB2	CTPS	IntAct	empirical	17620599
ARRB2	ADRB2	HPRD, BioGRID	empirical	17666399 16368719
ARRB2	AP2A1	IntAct	empirical	17620599
ARRB2	AP2A2	IntAct	empirical	17620599
ARRB2	AP1B1	HPRD	empirical	10097102 12070169
ARRB2	DBN1	IntAct	empirical	17620599
ARRB2	AP2B1	IntAct, BioGRID	empirical	17620599 10097102 12070169
ARRB2	DDX1	IntAct	empirical	17620599
ARRB2	DDX3X	IntAct	empirical	17620599
ARRB2	DDX5	IntAct	empirical	17620599
ARRB2	DHX15	IntAct	empirical	17620599
ARRB2	SPIN3	IntAct	empirical	17620599
ARRB2	DKC1	IntAct	empirical	17620599
ARRB2	DYNC1H1	IntAct	empirical	17620599
ARRB2	DRD4	BioGRID	empirical	20100572
ARRB2	AGTR1	HPRD, MINT, BioGRID	empirical	11279203 16359671 11226259
ARRB2	DVL2	HPRD	empirical	12958364
ARRB2	EEF1A1	IntAct	empirical	17620599
ARRB2	EEF1A2	IntAct	empirical	17620599
ARRB2	EEF2	IntAct	empirical	17620599
ARRB2	EIF4B	IntAct	empirical	17620599
ARRB2	CTTN	IntAct	empirical	17620599
ARRB2	AKT1	IntAct, BioGRID	empirical	18191226 16051150
ARRB2	ERH	IntAct	empirical	17620599
ARRB2	FBL	IntAct, BioGRID	empirical	17353931 17620599
ARRB2	F2R	Reactome	predicted	16580177
ARRB2	FASN	IntAct	empirical	17620599
ARRB2	TWISTNB	IntAct	empirical	17620599
ARRB2	USP33	BioGRID	empirical	19424180 19363159
ARRB2	EPB41L3	IntAct	empirical	17620599
ARRB2	FLNA	HPRD, IntAct	empirical	16611986 17620599
ARRB2	BOP1	IntAct, BioGRID	empirical	17353931
ARRB2	ARHGEF12	IntAct	empirical	17620599
ARRB2	SF3B3	IntAct	empirical	17620599
ARRB2	SF3B1	IntAct	empirical	17620599
ARRB2	PES1	IntAct, BioGRID	empirical	17353931
ARRB2	SRRM2	IntAct	empirical	17620599
ARRB2	XRCC6	IntAct	empirical	17620599
ARRB2	RPL36	IntAct	empirical	17620599
ARRB2	POLR1A	IntAct	empirical	17620599
ARRB2	GAPDH	IntAct	empirical	17620599
ARRB2	RAB11FIP5	IntAct	empirical	17620599
ARRB2	SERBP1	IntAct	empirical	17620599
ARRB2	PABPC1	IntAct	empirical	17620599
ARRB2	HTATSF1	IntAct	empirical	17620599
ARRB2	RPL7L1	IntAct, BioGRID	empirical	17353931
ARRB2	GSK3B	IntAct	empirical	16051150
ARRB2	GSN	IntAct	empirical	17620599
ARRB2	TMOD3	IntAct	empirical	17620599
ARRB2	HIST1H1C	IntAct	empirical	17620599
ARRB2	H2AFX	IntAct	empirical	17620599
ARRB2	ANXA2	IntAct	empirical	17620599
ARRB2	HIST1H1A	IntAct	empirical	17620599
ARRB2	HDAC2	IntAct	empirical	17620599
ARRB2	HIST2H2AB	IntAct	empirical	17620599
ARRB2	HNRNPA1	IntAct	empirical	17620599
ARRB2	HNRNPC	IntAct	empirical	17620599
ARRB2	HNRNPD	IntAct	empirical	17620599
ARRB2	HNRNPF	IntAct	empirical	17620599
ARRB2	HNRNPH1	IntAct	empirical	17620599
ARRB2	HNRNPH2	IntAct	empirical	17620599
ARRB2	HNRNPK	IntAct	empirical	17620599
ARRB2	HNRNPU	IntAct	empirical	17620599
ARRB2	PRMT1	IntAct	empirical	17620599
ARRB2	HSPA1L	IntAct	empirical	17620599
ARRB2	HSPA5	IntAct	empirical	17620599
ARRB2	HSPA6	IntAct	empirical	17620599
ARRB2	HSPA8	IntAct	empirical	17620599
ARRB2	HSP90AB1	IntAct	empirical	17620599
ARRB2	HTR2C	HPRD, IntAct	empirical	18768750 16319069
ARRB2	O3FAR1	IntAct	empirical	20813258
ARRB2	ACTBL2	IntAct	empirical	17620599
ARRB2	IGF1R	BioGRID	empirical	19165858
ARRB2	ILF3	IntAct	empirical	17620599
ARRB2	NDUFS7	HPRD, MINT, IntAct	empirical	16169070
ARRB2	ARF6	HPRD, BioGRID	empirical	11533043 11867621
ARRB2	KPNB1	IntAct	empirical	17620599
ARRB2	KPNA3	IntAct, BioGRID	empirical	17353931
ARRB2	KPNA4	IntAct, BioGRID	empirical	17353931
ARRB2	LBR	IntAct	empirical	17620599
ARRB2	LHCGR	BioGRID	empirical	11867621
ARRB2	LIMK1	IntAct	empirical	17500066
ARRB2	ARR3	IntAct	empirical	17620599
ARRB2	ARRB1	IntAct, BioGRID	empirical	17353931 17620599
ARRB2	ARRB2	IntAct	empirical	17620599
ARRB2	MAP1B	IntAct	empirical	17620599
ARRB2	MCM3	IntAct	empirical	17620599
ARRB2	MDM2	HPRD, MINT, IntAct, BioGRID	empirical	12538596 12488444 11588219 18191226 21988832 18544533 21466165 19372219 21389118
ARRB2	MAP3K1	IntAct	empirical	17620599
ARRB2	MAP3K5	HPRD, MINT, BioGRID	empirical	11356842 11090355 19306926
ARRB2	MLLT4	IntAct	empirical	17620599
ARRB2	EIF2AK4	IntAct	empirical	17620599
ARRB2	POTEKP	IntAct	empirical	17620599
ARRB2	MYH9	IntAct	empirical	17620599
ARRB2	MYH10	IntAct	empirical	17620599
ARRB2	MYL6	IntAct	empirical	17620599
ARRB2	MYO1C	IntAct	empirical	17620599
ARRB2	PPP1R12A	IntAct	empirical	17620599
ARRB2	HNRNPM	IntAct	empirical	17620599
ARRB2	NAP1L1	IntAct	empirical	17620599
ARRB2	NCL	IntAct	empirical	17620599
ARRB2	NFKBIA	HPRD	empirical	15125834 15173580
ARRB2	NKTR	IntAct	empirical	17620599
ARRB2	NONO	IntAct	empirical	17620599
ARRB2	NPM1	IntAct	empirical	17620599
ARRB2	YBX1	IntAct	empirical	17620599
ARRB2	NTS	HPRD	empirical	12473660
ARRB2	NTSR1	HPRD	empirical	11279203
ARRB2	OPRD1	HPRD, BioGRID	empirical	11259507
ARRB2	OXTR	HPRD	empirical	11279203
ARRB2	P4HB	IntAct	empirical	17620599
ARRB2	PABPC3	IntAct	empirical	17620599
ARRB2	PARK2	BioGRID	empirical	21466165
ARRB2	UBR5	IntAct	empirical	17620599
ARRB2	PDE4D	IntAct	empirical	17620599
ARRB2	LIMA1	IntAct	empirical	17620599
ARRB2	TUBA8	IntAct	empirical	17620599
ARRB2	PFKFB3	IntAct	empirical	17620599
ARRB2	PHKA2	IntAct	empirical	17620599
ARRB2	PIK3C2A	IntAct	empirical	17620599
ARRB2	PKM2	IntAct	empirical	17620599
ARRB2	POLR2E	IntAct	empirical	17620599
ARRB2	PPIA	IntAct	empirical	17620599
ARRB2	NSUN2	IntAct	empirical	17620599
ARRB2	PPM1A	IntAct	empirical	17620599
ARRB2	PPM1B	IntAct	empirical	17620599
ARRB2	ARHGAP17	IntAct	empirical	17620599
ARRB2	PPP2R1A	IntAct	empirical	17620599
ARRB2	PPP2R2B	IntAct	empirical	16051150
ARRB2	MOB1A	IntAct	empirical	17620599
ARRB2	C17orf79	IntAct	empirical	17620599
ARRB2	AVPR2	HPRD, BioGRID	empirical	12473660
ARRB2	NOP10	IntAct	empirical	17620599
ARRB2	DDX27	IntAct, BioGRID	empirical	17353931
ARRB2	SCYL2	IntAct	empirical	17620599
ARRB2	VPS35	IntAct	empirical	17620599
ARRB2	MAPK1	HPRD, IntAct, BioGRID	empirical	11226259 18191226 17620599 15699045
ARRB2	MAPK3	IntAct, BioGRID	empirical	18191226 12473660
ARRB2	MAPK9	IntAct	empirical	19060904
ARRB2	MAPK10	HPRD, MINT, BioGRID	empirical	11090355 11356842
ARRB2	MAP2K1	BioGRID	empirical	11226259
ARRB2	PAK7	IntAct	empirical	17620599
ARRB2	PTAFR	HPRD, BioGRID	empirical	11729201 9037196
ARRB2	PTBP1	IntAct	empirical	17620599
ARRB2	ARHGAP21	IntAct	empirical	17620599
ARRB2	RAB5C	IntAct, BioGRID	empirical	17353931
ARRB2	RAF1	HPRD, IntAct, BioGRID	empirical	11226259 18191226 17666399
ARRB2	RALGDS	HPRD, BioGRID	empirical	12105416
ARRB2	RANGAP1	IntAct	empirical	17620599
ARRB2	TRPV4	IntAct	empirical	17620599
ARRB2	ACTB	IntAct	empirical	17620599
ARRB2	RPA1	IntAct	empirical	17620599
ARRB2	RPL3	IntAct	empirical	17620599
ARRB2	RPL4	IntAct	empirical	17620599
ARRB2	RPL6	IntAct	empirical	17620599
ARRB2	RPL7	IntAct	empirical	17620599
ARRB2	RPL7A	IntAct	empirical	17620599
ARRB2	RPL11	IntAct	empirical	17620599
ARRB2	RPL12	IntAct	empirical	17620599
ARRB2	RPL15	IntAct	empirical	17620599
ARRB2	RPL18	IntAct	empirical	17620599
ARRB2	RPL19	IntAct	empirical	17620599
ARRB2	RPL21	IntAct	empirical	17620599
ARRB2	RPL22	IntAct	empirical	17620599
ARRB2	RPL26	IntAct	empirical	17620599
ARRB2	RPL30	IntAct	empirical	17620599
ARRB2	RPL28	IntAct	empirical	17620599
ARRB2	RPL31	IntAct	empirical	17620599
ARRB2	RPL35A	IntAct	empirical	17620599
ARRB2	RPLP0	IntAct	empirical	17620599
ARRB2	RPLP1	IntAct	empirical	17620599
ARRB2	RPLP2	IntAct	empirical	17620599
ARRB2	RPN2	IntAct	empirical	17620599
ARRB2	RPS3	IntAct	empirical	17620599
ARRB2	RPS3A	IntAct	empirical	17620599
ARRB2	RPS4X	IntAct	empirical	17620599
ARRB2	RPS6	IntAct	empirical	17620599
ARRB2	RPS7	IntAct	empirical	17620599
ARRB2	RPS8	IntAct	empirical	17620599
ARRB2	RPS13	IntAct	empirical	17620599
ARRB2	RPS17	IntAct	empirical	17620599
ARRB2	RPS19	IntAct	empirical	17620599
ARRB2	RPS27A	IntAct	empirical	17620599
ARRB2	S100A9	IntAct	empirical	17620599
ARRB2	SAG	IntAct	empirical	17620599
ARRB2	SDHA	IntAct	empirical	17620599
ARRB2	MAP2K4	MINT, BioGRID	empirical	11090355
ARRB2	SFPQ	IntAct	empirical	17620599
ARRB2	MRPL44	IntAct, BioGRID	empirical	17353931
ARRB2	BOLA2B	IntAct	empirical	17620599
ARRB2	SLC9A5	HPRD	empirical	15699339
ARRB2	SMARCC2	HPRD, MINT, IntAct, BioGRID	empirical	16169070
ARRB2	SNRPD1	IntAct	empirical	17620599
ARRB2	SNRPD2	IntAct	empirical	17620599
ARRB2	SPTAN1	IntAct	empirical	17620599
ARRB2	SPTBN1	IntAct	empirical	17620599
ARRB2	SRPK2	IntAct	empirical	17620599
ARRB2	STAT1	IntAct	empirical	17620599
ARRB2	MAP3K7	IntAct	empirical	17620599
ARRB2	TCOF1	IntAct, BioGRID	empirical	17353931 17620599
ARRB2	ACTC1	IntAct	empirical	17620599
ARRB2	TGFBR3	HPRD	empirical	12958365
ARRB2	C1QBP	IntAct	empirical	17620599
ARRB2	TMPO	IntAct	empirical	17620599
ARRB2	TRAF3	BioGRID	empirical	11226259
ARRB2	ACTG2	IntAct	empirical	17620599
ARRB2	TRH	HPRD	empirical	12473660
ARRB2	TUBA4A	IntAct	empirical	17620599
ARRB2	C5AR1	HPRD	empirical	12464600
ARRB2	TUBB2A	IntAct	empirical	17620599
ARRB2	UBA52	IntAct	empirical	17620599
ARRB2	UBB	IntAct	empirical	17620599
ARRB2	UBC	IntAct, BioGRID	empirical	17620599 17666399 15782195 15699045 12574160 11588219 19363159 21466165 19996297 21890473 21906983
ARRB2	VCP	IntAct	empirical	17620599
ARRB2	VIM	IntAct	empirical	17620599
ARRB2	WEE1	IntAct	empirical	17620599
ARRB2	XRCC5	IntAct	empirical	17620599
ARRB2	YWHAB	IntAct	empirical	17620599
ARRB2	YWHAE	IntAct	empirical	17620599
ARRB2	YWHAG	IntAct	empirical	17620599
ARRB2	YWHAH	IntAct	empirical	17620599
ARRB2	TUBA1A	IntAct	empirical	17620599
ARRB2	CXCR4	HPRD	empirical	10644702
ARRB2	KCNAB1	IntAct	empirical	17620599
ARRB2	WDR77	IntAct	empirical	17620599
ARRB2	WDR26	IntAct	empirical	17620599
ARRB2	CUL5	IntAct	empirical	17620599
ARRB2	AP3B2	IntAct	empirical	17620599
ARRB2	CAMK2D	IntAct	empirical	17620599
ARRB2	ARPC5L	IntAct	empirical	17620599
ARRB2	CAPN1	IntAct	empirical	17620599
ARRB2	RBM10	IntAct	empirical	17620599
ARRB2	NAA10	IntAct, BioGRID	empirical	17620599 20360068
ARRB2	CAPZA1	IntAct	empirical	17620599
ARRB2	CAPZA2	IntAct	empirical	17620599
ARRB2	FZD4	HPRD	empirical	12958364
ARRB2	HIST1H2BO	IntAct	empirical	17620599
ARRB2	ITCH	BioGRID	empirical	18544533 17947233
ARRB2	POLR1B	IntAct	empirical	17620599
ARRB2	MRPL43	IntAct, BioGRID	empirical	17353931
ARRB2	HDGFRP2	IntAct	empirical	17620599
ARRB2	TUBA1C	IntAct	empirical	17620599
ARRB2	LRP11	IntAct	empirical	17620599
ARRB2	DGKZ	IntAct	empirical	17620599
ARRB2	DGKE	IntAct	empirical	17620599
ARRB2	CSDA	IntAct	empirical	17620599
ARRB2	AP3B1	IntAct, BioGRID	empirical	17353931
ARRB2	STC2	HPRD, MINT, IntAct, BioGRID	empirical	16169070
ARRB2	CDK13	IntAct	empirical	17620599
ARRB2	PABPC4	IntAct	empirical	17620599
ARRB2	PRPF4B	IntAct	empirical	17620599
ARRB2	CPNE1	IntAct	empirical	17620599
ARRB2	BSN	IntAct	empirical	17620599
ARRB2	AP3D1	IntAct	empirical	17620599
ARRB2	H1FX	IntAct	empirical	17620599
ARRB2	MAP3K14	IntAct	empirical	17620599
ARRB2	RPL14	IntAct	empirical	17620599
ARRB2	CCT6A	IntAct	empirical	17620599
ARRB2	NOLC1	IntAct, BioGRID	empirical	17353931 17620599
ARRB2	CYTH2	HPRD, BioGRID	empirical	11533043
ARRB2	GPR56	BioGRID	empirical	21708946
ARRB2	EFTUD2	IntAct	empirical	17620599
ARRB2	MYOCD	IntAct	empirical	17620599
ARRB2	ZRANB2	IntAct	empirical	17620599
ARRB2	ARHGEF6	IntAct	empirical	17620599
ARRB2	POLR1C	IntAct	empirical	17620599
ARRB2	SDC3	IntAct	empirical	17620599
ARRB2	BCLAF1	IntAct	empirical	17620599
ARRB2	ARHGEF11	IntAct	empirical	17620599
ARRB2	G3BP2	IntAct	empirical	17620599
ARRB2	THRAP3	IntAct	empirical	17620599
ARRB2	CDC42	IntAct, BioGRID	empirical	20936779