SMAD4

Summary Top Help

Gene Description:

SMAD family member 4; MAD homolog 4 (Drosophila)

Synonyms:

MYHRS, DPC4, MADH4, SMAD4, Madh4, Smad4, JIP, D18Wsu70e, AW743858

Orthologs:

Human SMAD4 (protein-coding), Mouse Smad4 (protein-coding), Rat Smad4 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 2 Rat: 1

Linkage Regions: 2 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd21.1	Mouse	chr18:69192440..90772031	21.58	97
Idd21.2	Mouse	chr18:64618429..74588997	9.97	69

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm35	Rat	chr18:4320091..76880933	72.56	466

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr18:48494387..48611415 (1173 kb) View in Genome Browser

(Mouse) NCBIM37 - chr18:73798663..73863434 (64.77 kb) View in Genome Browser

(Rat) RGSC3.4 - chr18:70432705..70461613 (28.91 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for SMAD4:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for SMAD4:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 8

Biocarta: 7

Reactome: 2

NCI-Nature Pathway Interaction Database: 11

Gene Ontology: 63

Core promoter proximal region sequence-specific DNA binding	GO:0000987
Protein binding transcription factor activity	GO:0000988
Branching involved in ureteric bud morphogenesis	GO:0001658
Response to hypoxia	GO:0001666
In utero embryonic development	GO:0001701
Gastrulation with mouth forming second	GO:0001702
Kidney development	GO:0001822
DNA binding	GO:0003677
Chromatin binding	GO:0003682
Sequence-specific DNA binding transcription factor activity	GO:0003700
Protein binding	GO:0005515
Collagen binding	GO:0005518
Intracellular	GO:0005622
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Transcription factor complex	GO:0005667
Nucleolus	GO:0005730
Cytoplasm	GO:0005737
Centrosome	GO:0005813
Cytosol	GO:0005829
Transforming growth factor beta receptor signaling pathway	GO:0007179
SMAD protein complex assembly	GO:0007183
Endoderm development	GO:0007492
Mesoderm development	GO:0007498
Negative regulation of cell proliferation	GO:0008285
Anterior/posterior pattern specification	GO:0009952
Positive regulation of epithelial to mesenchymal transition	GO:0010718
Positive regulation of pathway-restricted SMAD protein phosphorylation	GO:0010862
Neural crest cell differentiation	GO:0014033
Regulation of transforming growth factor beta receptor signaling pathway	GO:0017015
Negative regulation of cell growth	GO:0030308
BMP signaling pathway	GO:0030509
Positive regulation of transforming growth factor beta receptor signaling pathway	GO:0030511
Transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	GO:0030616
Activin responsive factor complex	GO:0032444
Somite rostral/caudal axis specification	GO:0032525
Regulation of transforming growth factor beta2 production	GO:0032909
Negative regulation of protein catabolic process	GO:0042177
Identical protein binding	GO:0042802
Protein homodimerization activity	GO:0042803
Sequence-specific DNA binding	GO:0043565
Transcription regulatory region DNA binding	GO:0044212
Negative regulation of transcription, DNA-dependent	GO:0045892
Positive regulation of transcription, DNA-dependent	GO:0045893
Positive regulation of transcription from RNA polymerase II promoter	GO:0045944
SMAD binding	GO:0046332
Developmental growth	GO:0048589
Neuron fate commitment	GO:0048663
Tissue morphogenesis	GO:0048729
Sebaceous gland development	GO:0048733
Formation of anatomical boundary	GO:0048859
Regulation of binding	GO:0051098
Regulation of hair follicle development	GO:0051797
Palate development	GO:0060021
Positive regulation of SMAD protein import into nucleus	GO:0060391
SMAD protein signal transduction	GO:0060395
Negative regulation of cell death	GO:0060548
I-SMAD binding	GO:0070411
R-SMAD binding	GO:0070412
SMAD protein complex	GO:0071141
Response to transforming growth factor beta stimulus	GO:0071559
Metanephric mesenchyme morphogenesis	GO:0072133
Nephrogenic mesenchyme morphogenesis	GO:0072134

Publications from PubMed Top Help

Type 1 Diabetes Publications: 7

Publications: 644

Human ovarian cancer cell morphology, motility, and proliferation are differentially influenced by autocrine TGFβ superfamily signalling.
Thériault BL, Nachtigal MW
Cancer Lett. 2011
PubMed ID: 21945631
Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension.
Nasim MT, Ogo T, Ahmed M, Randall R, Chowdhury HM, Snape KM, Bradshaw TY, Southgate L, Lee GJ, Jackson I, Lord GM, Gibbs JS, Wilkins MR, Ohta-Ogo K, Nakamura K, Girerd B, Coulet F, Soubrier F, Humbert M, Morrell NW, Trembath RC, Machado RD
Hum Mutat. 2011
PubMed ID: 21898662
Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3.
Tang LY, Yamashita M, Coussens NP, Tang Y, Wang X, Li C, Deng CX, Cheng SY, Zhang YE
EMBO J. 2011
PubMed ID: 22045334
SMAD4 protein expression and cell proliferation in colorectal adenocarcinomas.
Handra-Luca A, Olschwang S, Fléjou JF
Virchows Arch. 2011
PubMed ID: 22002709
USP15 is a deubiquitylating enzyme for receptor-activated SMADs.
Inui M, Manfrin A, Mamidi A, Martello G, Morsut L, Soligo S, Enzo E, Moro S, Polo S, Dupont S, Cordenonsi M, Piccolo S
Nat Cell Biol. 2011
PubMed ID: 21947082
TGF-β1 inhibits the growth and metastasis of tongue squamous carcinoma cells through Smad4.
Wang X, Sun W, Zhang C, Ji G, Ge Y, Xu Y, Zhao Y
Gene. 2011
PubMed ID: 21726607
Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice.
Hahn JN, Falck VG, Jirik FR
J Clin Invest. 2011
PubMed ID: 21881210
TGF-β signaling via Smad4 drives IL-10 production in effector Th1 cells and reduces T-cell trafficking in EAE.
Huss DJ, Winger RC, Cox GM, Guerau-de-Arellano M, Yang Y, Racke MK, Lovett-Racke AE
Eur J Immunol. 2011
PubMed ID: 21728174
The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation.
Costello I, Pimeisl IM, Dräger S, Bikoff EK, Robertson EJ, Arnold SJ
Nat Cell Biol. 2011
PubMed ID: 21822279
Resveratrol selectively induces DNA Damage, independent of Smad4 expression, in its efficacy against human head and neck squamous cell carcinoma.
Tyagi A, Gu M, Takahata T, Frederick B, Agarwal C, Siriwardana S, Agarwal R, Sclafani RA
Clin Cancer Res. 2011
PubMed ID: 21705453
TGF-β signals the formation of a unique NF1/Smad4-dependent transcription repressor-complex in human diploid fibroblasts.
Luciakova K, Kollarovic G, Kretova M, Sabova L, Nelson BD
Biochem Biophys Res Commun. 2011
PubMed ID: 21782795
Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression.
Crane CH, Varadhachary GR, Yordy JS, Staerkel GA, Javle MM, Safran H, Haque W, Hobbs BD, Krishnan S, Fleming JB, Das P, Lee JE, Abbruzzese JL, Wolff RA
J Clin Oncol. 2011
PubMed ID: 21709185
Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities.
Agricola E, Randall RA, Gaarenstroom T, Dupont S, Hill CS
Mol Cell. 2011
PubMed ID: 21726812
Antagonistic regulation of EMT by TIF1γ and Smad4 in mammary epithelial cells.
Hesling C, Fattet L, Teyre G, Jury D, Gonzalo P, Lopez J, Vanbelle C, Morel AP, Gillet G, Mikaelian I, Rimokh R
EMBO Rep. 2011
PubMed ID: 21597466
Discovery of SMAD4 promoters, transcription factor binding sites and deletions in juvenile polyposis patients.
Calva D, Dahdaleh FS, Woodfield G, Weigel RJ, Carr JC, Chinnathambi S, Howe JR
Nucleic Acids Res. 2011
PubMed ID: 21421563
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Smad4 binds Hoxa9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by Hoxa9 and leukemia transformation.
Quéré R, Karlsson G, Hertwig F, Rissler M, Lindqvist B, Fioretos T, Vandenberghe P, Slovak ML, Cammenga J, Karlsson S
Blood. 2011
PubMed ID: 21471525
Aberrant TGFβ/SMAD4 signaling contributes to epigenetic silencing of a putative tumor suppressor, RunX1T1 in ovarian cancer.
Yeh KT, Chen TH, Yang HW, Chou JL, Chen LY, Yeh CM, Chen YH, Lin RI, Su HY, Chen GC, Deatherage DE, Huang YW, Yan PS, Lin HJ, Nephew KP, Huang TH, Lai HC, Chan MW
Epigenetics. 2011
PubMed ID: 21540640
Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas.
Xu CR, Cole PA, Meyers DJ, Kormish J, Dent S, Zaret KS
Science. 2011
PubMed ID: 21596989
β-Catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4.
Paek H, Hwang JY, Zukin RS, Hébert JM
Dev Cell. 2011
PubMed ID: 21571225
Molecular mechanism of the negative regulation of Smad1/5 protein by carboxyl terminus of Hsc70-interacting protein (CHIP).
Wang L, Liu YT, Hao R, Chen L, Chang Z, Wang HR, Wang ZX, Wu JW
J Biol Chem. 2011
PubMed ID: 21454478
Molecular regulatory mechanism of root development.
Hung Y, Huang X, Chai Y
J Calif Dent Assoc. 2011
PubMed ID: 21721476
SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis.
Li J, Huang X, Xu X, Mayo J, Bringas P, Jiang R, Wang S, Chai Y
Development. 2011
PubMed ID: 21490069
SMAD4 mutation segregating in a family with juvenile polyposis, aortopathy, and mitral valve dysfunction.
Andrabi S, Bekheirnia MR, Robbins-Furman P, Lewis RA, Prior TW, Potocki L
Am J Med Genet A. 2011
PubMed ID: 21465659
Deletion of Smad4 in fibroblasts leads to defective chondrocyte maturation and cartilage production in a TGFβ type II receptor independent manner.
Teng Y, Kanasaki K, Bardeesy N, Sugimoto H, Kalluri R
Biochem Biophys Res Commun. 2011
PubMed ID: 21376704
Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice.
Holm TM, Habashi JP, Doyle JJ, Bedja D, Chen Y, van Erp C, Lindsay ME, Kim D, Schoenhoff F, Cohn RD, Loeys BL, Thomas CJ, Patnaik S, Marugan JJ, Judge DP, Dietz HC
Science. 2011
PubMed ID: 21493862
Histologic variations in juvenile polyp phenotype correlate with genetic defect underlying juvenile polyposis.
van Hattem WA, Langeveld D, de Leng WW, Morsink FH, van Diest PJ, Iacobuzio-Donahue CA, Giardiello FM, Offerhaus GJ, Brosens LA
Am J Surg Pathol. 2011
PubMed ID: 21412070
Two models of Smad4 and Hoxa9 complex are proposed: structural and interactional perspective.
Roy S, Thakur AR
J Biomol Struct Dyn. 2011
PubMed ID: 21294585
Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling.
Chaston TB, Matak P, Pourvali K, Srai SK, McKie AT, Sharp PA
Am J Physiol Cell Physiol. 2011
PubMed ID: 21289291
MicroRNA 421 suppresses DPC4/Smad4 in pancreatic cancer.
Hao J, Zhang S, Zhou Y, Liu C, Hu X, Shao C
Biochem Biophys Res Commun. 2011
PubMed ID: 21352803
Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch.
Li F, Lan Y, Wang Y, Wang J, Yang G, Meng F, Han H, Meng A, Wang Y, Yang X
Dev Cell. 2011
PubMed ID: 21397841
Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]
Moskowitz IP, Wang J, Peterson MA, Pu WT, Mackinnon AC, Oxburgh L, Chu GC, Sarkar M, Berul C, Smoot L, Robertson EJ, Schwartz R, Seidman JG, Seidman CE
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21330551
Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling.
da Silva S, Hasegawa H, Scott A, Zhou X, Wagner AK, Han BX, Wang F
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21300867
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.
Ding Z, Wu CJ, Chu GC, Xiao Y, Ho D, Zhang J, Perry SR, Labrot ES, Wu X, Lis R, Hoshida Y, Hiller D, Hu B, Jiang S, Zheng H, Stegh AH, Scott KL, Signoretti S, Bardeesy N, Wang YA, Hill DE, Golub TR, Stampfer MJ, Wong WH, Loda M, Mucci L, Chin L, DePinho RA
Nature. 2011
PubMed ID: 21289624
Ovarian metastases of pancreaticobiliary tract adenocarcinomas: analysis of 35 cases, with emphasis on the ability of metastases to simulate primary ovarian mucinous tumors.
Meriden Z, Yemelyanova AV, Vang R, Ronnett BM
Am J Surg Pathol. 2011
PubMed ID: 21263249
Smad4 inactivation promotes malignancy and drug resistance of colon cancer.
Papageorgis P, Cheng K, Ozturk S, Gong Y, Lambert AW, Abdolmaleky HM, Zhou JR, Thiagalingam S
Cancer Res. 2011
PubMed ID: 21245094
Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.
Campbell GR, Baudhuin A, Vranizan K, Ngai J
Mol Cell Neurosci. 2011
PubMed ID: 21194568
The role of Smad4 in vestibular development in mice.
Yang SM, Deng AC, Huang DL, Sun JH, Yang G, Yu YP, Hou ZH, Guo WW, Zhai SQ, He DZ, Han DY, Young WY, Yang X
Int J Dev Neurosci. 2011
PubMed ID: 20969946
MicroRNA 483-3p suppresses the expression of DPC4/Smad4 in pancreatic cancer.
Hao J, Zhang S, Zhou Y, Hu X, Shao C
FEBS Lett. 2011
PubMed ID: 21112326
Reduced expression of SMAD4 in gliomas correlates with progression and survival of patients.
He SM, Zhao ZW, Wang Y, Zhao JP, Wang L, Hou F, Gao GD
J Exp Clin Cancer Res. 2011
PubMed ID: 21791112
Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA
PLoS One. 2011
PubMed ID: 21731673
Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε.
Liffers ST, Maghnouj A, Munding JB, Jackstadt R, Herbrand U, Schulenborg T, Marcus K, Klein-Scory S, Schmiegel W, Schwarte-Waldhoff I, Meyer HE, Stühler K, Hahn SA
BMC Cancer. 2011
PubMed ID: 21492476
Smad4 Is Required Predominantly in the Developmental Processes Dependent on the BMP Branch of the TGF-{beta} Signaling System in the Embryonic Mouse Retina.
Murali D, Kawaguchi-Niida M, Deng CX, Furuta Y
Invest Ophthalmol Vis Sci. 2011
PubMed ID: 21273545
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryos.
Song L, Zhao M, Wu B, Zhou B, Wang Q, Jiao K
Dev Dyn. 2011
PubMed ID: 21089072
The suppression of CRMP2 expression by bone morphogenetic protein (BMP)-SMAD gradient signaling controls multiple stages of neuronal development.
Sun Y, Fei T, Yang T, Zhang F, Chen YG, Li H, Xu Z
J Biol Chem. 2010
PubMed ID: 20926379
Induction of interleukin-6 expression by bone morphogenetic protein-6 in macrophages requires both SMAD and p38 signaling pathways.
Lee GT, Kwon SJ, Lee JH, Jeon SS, Jang KT, Choi HY, Lee HM, Kim WJ, Kim SJ, Kim IY
J Biol Chem. 2010
PubMed ID: 20889504
Genetic variations in the SMAD4 gene and gastric cancer susceptibility.
Wu DM, Zhu HX, Zhao QH, Zhang ZZ, Wang SZ, Wang ML, Gong WD, Tan M, Zhang ZD
World J Gastroenterol. 2010
PubMed ID: 21105199
PARP-1 attenuates Smad-mediated transcription.
Lönn P, van der Heide LP, Dahl M, Hellman U, Heldin CH, Moustakas A
Mol Cell. 2010
PubMed ID: 21095583
Genetic variation in the TGF{beta}-signaling pathway and colon and rectal cancer risk.
Slattery ML, Herrick J, Lundgreen A, Wolff RK
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 21068203
The oncoprotein c-ski functions as a direct antagonist of the transforming growth factor-{beta} type I receptor.
Ferrand N, Atfi A, Prunier C
Cancer Res. 2010
PubMed ID: 20959473
Proteomics of Smad4 regulated transforming growth factor-beta signalling in colon cancer cells.
Ali NA, McKay MJ, Molloy MP
Mol Biosyst. 2010
PubMed ID: 20862427
A large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ
Hum Genet. 2010
PubMed ID: 20734064
Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells.
Zhao S, Wang Y, Cao L, Ouellette MM, Freeman JW
Int J Cancer. 2010
PubMed ID: 20473902
Structural and functional analysis of SMAD4 gene promoter in malignant pancreatic and colorectal tissues: Detection of two novel polymorphic nucleotide repeats.
Nikolic A, Kojic S, Knezevic S, Krivokapic Z, Ristanovic M, Radojkovic D
Cancer Epidemiol. 2010
PubMed ID: 21036691
HGF upregulation contributes to angiogenesis in mice with keratinocyte-specific Smad2 deletion.
Hoot KE, Oka M, Han G, Bottinger E, Zhang Q, Wang XJ
J Clin Invest. 2010
PubMed ID: 20852387
Inactivation of Smad4 leads to impaired ocular development and cataract formation.
Liu Y, Kawai K, Khashabi S, Deng C, Liu YH, Yiu S
Biochem Biophys Res Commun. 2010
PubMed ID: 20735985
Role of reduced expression of SMAD4 in papillary thyroid carcinoma.
D'Inzeo S, Nicolussi A, Ricci A, Mancini P, Porcellini A, Nardi F, Coppa A
J Mol Endocrinol. 2010
PubMed ID: 20685810
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Brown adipose tissue function in short-chain acyl-CoA dehydrogenase deficient mice.
Skilling H, Coen PM, Fairfull L, Ferrell RE, Goodpaster BH, Vockley J, Goetzman ES
Biochem Biophys Res Commun. 2010
PubMed ID: 20727852
Atp4b promoter directs the expression of Cre recombinase in gastric parietal cells of transgenic mice.
Zhao Z, Hou N, Sun Y, Teng Y, Yang X
J Genet Genomics. 2010
PubMed ID: 20933217
Synergistic repression of estrogen receptor transcriptional activity by FHL2 and Smad4 in breast cancer cells.
Xiong Z, Ding L, Sun J, Cao J, Lin J, Lu Z, Liu Y, Huang C, Ye Q
IUBMB Life. 2010
PubMed ID: 20734429
H3K27me3 regulates BMP activity in developing spinal cord.
Akizu N, Estarás C, Guerrero L, Martí E, Martínez-Balbás MA
Development. 2010
PubMed ID: 20667911
Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells.
Ang CW, Nedjadi T, Sheikh AA, Tweedle EM, Tonack S, Honap S, Jenkins RE, Park BK, Schwarte-Waldhoff I, Khattak I, Azadeh B, Dodson A, Kalirai H, Neoptolemos JP, Rooney PS, Costello E
Carcinogenesis. 2010
PubMed ID: 20622003
Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM).
Carter H, Samayoa J, Hruban RH, Karchin R
Cancer Biol Ther. 2010
PubMed ID: 20581473
Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes.
Kaimori A, Potter JJ, Choti M, Ding Z, Mezey E, Koteish AA
Hepatology. 2010
PubMed ID: 20564330
SMAD4 immunohistochemistry reflects genetic status in juvenile polyposis syndrome.
Langeveld D, van Hattem WA, de Leng WW, Morsink FH, Ten Kate FJ, Giardiello FM, Offerhaus GJ, Brosens LA
Clin Cancer Res. 2010
PubMed ID: 20682711
Smad4 mediates malignant behaviors of human ovarian carcinoma cell through the effect on expressions of E-cadherin, plasminogen activator inhibitor-1 and VEGF.
Chen C, Sun MZ, Liu S, Yeh D, Yu L, Song Y, Gong L, Hao L, Hu J, Shao S
BMB Rep. 2010
PubMed ID: 20797318
Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo.
Morsut L, Yan KP, Enzo E, Aragona M, Soligo SM, Wendling O, Mark M, Khetchoumian K, Bressan G, Chambon P, Dupont S, Losson R, Piccolo S
Development. 2010
PubMed ID: 20573697
Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus.
Mira H, Andreu Z, Suh H, Lie DC, Jessberger S, Consiglio A, San Emeterio J, Hortigüela R, Marqués-Torrejón MA, Nakashima K, Colak D, Götz M, Fariñas I, Gage FH
Cell Stem Cell. 2010
PubMed ID: 20621052
SMAD4 mediates mesenchymal-epithelial reversion in SW480 colon carcinoma cells.
Pohl M, Radacz Y, Pawlik N, Schoeneck A, Baldus SE, Munding J, Schmiegel W, Schwarte-Waldhoff I, Reinacher-Schick A
Anticancer Res. 2010
PubMed ID: 20682989
Targeting Smad4 links microRNA-146a to the TGF-beta pathway during retinoid acid induction in acute promyelocytic leukemia cell line.
Zhong H, Wang HR, Yang S, Zhong JH, Wang T, Wang C, Chen FY
Int J Hematol. 2010
PubMed ID: 20577838
SMAD4: a predictive marker of PDAC cell permissiveness for oncolytic infection with parvovirus H-1PV.
Dempe S, Stroh-Dege AY, Schwarz E, Rommelaere J, Dinsart C
Int J Cancer. 2010
PubMed ID: 19856310
Activin A, a product of fetal Leydig cells, is a unique paracrine regulator of Sertoli cell proliferation and fetal testis cord expansion.
Archambeault DR, Yao HH
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20498064
[Expressions of transforming growth factor-beta(1) and Smad4 in rat models of chronic nonbacterial prostatitis and their clinical significance].
Wang YM, Lu SL, Zhao ZQ, Zhao YH, Wang N, Jing DS, Dong YC
Zhonghua Nan Ke Xue. 2010
PubMed ID: 20608350
Activin A induction of FSHbeta subunit transcription requires SMAD4 in immortalized gonadotropes.
Wang Y, Libasci V, Bernard DJ
J Mol Endocrinol. 2010
PubMed ID: 20371653
SMAD4 is required for development of maximal endotoxin tolerance.
Pan H, Ding E, Hu M, Lagoo AS, Datto MB, Lagoo-Deenadayalan SA
J Immunol. 2010
PubMed ID: 20404275
Dual roles of smad proteins in the conversion from myoblasts to osteoblastic cells by bone morphogenetic proteins.
Nojima J, Kanomata K, Takada Y, Fukuda T, Kokabu S, Ohte S, Takada T, Tsukui T, Yamamoto TS, Sasanuma H, Yoneyama K, Ueno N, Okazaki Y, Kamijo R, Yoda T, Katagiri T
J Biol Chem. 2010
PubMed ID: 20231279
The role of SMAD4 in human embryonic stem cell self-renewal and stem cell fate.
Avery S, Zafarana G, Gokhale PJ, Andrews PW
Stem Cells. 2010
PubMed ID: 20235236
Family-based analysis of candidate genes for polycystic ovary syndrome.
Ewens KG, Stewart DR, Ankener W, Urbanek M, McAllister JM, Chen C, Baig KM, Parker SC, Margulies EH, Legro RS, Dunaif A, Strauss JF, Spielman RS
J Clin Endocrinol Metab. 2010
PubMed ID: 20200332
Role of TGF-beta1, its receptor TGFbetaRII, and Smad proteins in the progression of colorectal cancer.
Gulubova M, Manolova I, Ananiev J, Julianov A, Yovchev Y, Peeva K
Int J Colorectal Dis. 2010
PubMed ID: 20165854
Smad4-Shh-Nfic signaling cascade-mediated epithelial-mesenchymal interaction is crucial in regulating tooth root development.
Huang X, Xu X, Bringas P, Hung YP, Chai Y
J Bone Miner Res. 2010
PubMed ID: 19888897
Canonical TGF-beta signaling is required for the balance of excitatory/inhibitory transmission within the hippocampus and prepulse inhibition of acoustic startle.
Sun M, Gewirtz JC, Bofenkamp L, Wickham RJ, Ge H, O'Connor MB
J Neurosci. 2010
PubMed ID: 20427661
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Dev Cell. 2010
PubMed ID: 20412781
Transforming growth factor-beta1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblasts.
Jablonska E, Markart P, Zakrzewicz D, Preissner KT, Wygrecka M
J Biol Chem. 2010
PubMed ID: 20142324
Expression of Smad and its signalling cascade in osteosarcoma.
Won KY, Kim YW, Park YK
Pathology. 2010
PubMed ID: 20350217
The predictive value of genes of the TGF-beta1 pathway in multimodally treated squamous cell carcinoma of the esophagus.
Pühringer-Oppermann F, Sarbia M, Ott N, Brücher BL
Int J Colorectal Dis. 2010
PubMed ID: 20012971
Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.
Roberts KE, Kawut SM, Krowka MJ, Brown RS, Trotter JF, Shah V, Peter I, Tighiouart H, Mitra N, Handorf E, Knowles JA, Zacks S, Fallon MB, Pulmonary Vascular Complications of Liver Disease Study Group
Gastroenterology. 2010
PubMed ID: 20346360
Identification of a Smad4/YY1-recognized and BMP2-responsive transcriptional regulatory module in the promoter of mouse GABA transporter subtype I (Gat1) gene.
Yao M, Niu G, Sheng Z, Wang Z, Fei J
J Neurosci. 2010
PubMed ID: 20237276
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4.
Yao G, Yin M, Lian J, Tian H, Liu L, Li X, Sun F
Mol Endocrinol. 2010
PubMed ID: 20118412
Changes in expression, and/or mutations in TGF-beta receptors (TGF-beta RI and TGF-beta RII) and Smad 4 in human ovarian tumors.
Antony ML, Nair R, Sebastian P, Karunagaran D
J Cancer Res Clin Oncol. 2010
PubMed ID: 19916025
The role of SMAD4 in early-onset colorectal cancer.
Royce SG, Alsop K, Haydon A, Mead L, Smith LD, Tesoriero AA, Giles GG, Jenkins MA, Hopper JL, Southey MC
Colorectal Dis. 2010
PubMed ID: 19183329
[Effects of Smad4 on liver fibrosis and hepatocarcinogenesis in mice treated with CCl4/ethanol].
Xu XB, He ZP, Leng XS, Liang ZQ, Peng JR, Zhang HY, Zhang HY, Xiao M, Zhang H, Liu CL, Zhang XD
Zhonghua Gan Zang Bing Za Zhi. 2010
PubMed ID: 20196951
Overlapping spectra of SMAD4 mutations in juvenile polyposis (JP) and JP-HHT syndrome.
Gallione C, Aylsworth AS, Beis J, Berk T, Bernhardt B, Clark RD, Clericuzio C, Danesino C, Drautz J, Fahl J, Fan Z, Faughnan ME, Ganguly A, Garvie J, Henderson K, Kini U, Leedom T, Ludman M, Lux A, Maisenbacher M, Mazzucco S, Olivieri C, Ploos van Amstel JK, Prigoda-Lee N, Pyeritz RE, Reardon W, Vandezande K, Waldman JD, White RI, Williams CA, Marchuk DA
Am J Med Genet A. 2010
PubMed ID: 20101697
Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis.
Su H, Kim H, Pawlikowska L, Kitamura H, Shen F, Cambier S, Markovics J, Lawton MT, Sidney S, Bollen AW, Kwok PY, Reichardt L, Young WL, Yang GY, Nishimura SL
Am J Pathol. 2010
PubMed ID: 20019187
Hyaluronan esters drive Smad gene expression and signaling enhancing cardiogenesis in mouse embryonic and human mesenchymal stem cells.
Maioli M, Santaniello S, Montella A, Bandiera P, Cantoni S, Cavallini C, Bianchi F, Lionetti V, Rizzolio F, Marchesi I, Bagella L, Ventura C
PLoS One. 2010
PubMed ID: 21152044
Anterior visceral endoderm SMAD4 signaling specifies anterior embryonic patterning and head induction in mice.
Li C, Li YP, Fu XY, Deng CX
Int J Biol Sci. 2010
PubMed ID: 20941375
TGFβ1 attenuates expression of prolactin and IGFBP-1 in decidualized endometrial stromal cells by both SMAD-dependent and SMAD-independent pathways.
Kane NM, Jones M, Brosens JJ, Kelly RW, Saunders PT, Critchley HO
PLoS One. 2010
PubMed ID: 20885978
Myocardial deletion of Smad4 using a novel α skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract.
Azhar M, Wang PY, Frugier T, Koishi K, Deng C, Noakes PG, McLennan IS
Int J Biol Sci. 2010
PubMed ID: 20877696
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC
PLoS One. 2010
PubMed ID: 20634891
SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene.
Sameer AS, Chowdri NA, Syeed N, Banday MZ, Shah ZA, Siddiqi MA
BMC Cancer. 2010
PubMed ID: 20565773
Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome.
Karner CM, Dietrich MF, Johnson EB, Kappesser N, Tennert C, Percin F, Wollnik B, Carroll TJ, Herz J
PLoS One. 2010
PubMed ID: 20454682
Uncoupled responses of Smad4-deficient cancer cells to TNFalpha result in secretion of monomeric laminin-gamma2.
Zboralski D, Warscheid B, Klein-Scory S, Malas MB, Becker H, Böckmann M, Meyer HE, Schmiegel W, Simon-Assmann P, Schwarte-Waldhoff I
Mol Cancer. 2010
PubMed ID: 20307265
Increased expression of TGF-beta1 and Smad 4 on oxygen-induced retinopathy in neonatal mice.
Yingchuan F, Chuntao L, Hui C, Jianbin H
Adv Exp Med Biol. 2010
PubMed ID: 20238004
Epidermal Smad4 deletion results in aberrant wound healing.
Owens P, Engelking E, Han G, Haeger SM, Wang XJ
Am J Pathol. 2010
PubMed ID: 19959815
Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination.
Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Chen Z, Xiao H, Han JD, Chen YG
Genome Res. 2010
PubMed ID: 19926752
Human SMAD4 is phosphorylated at Thr9 and Ser138 by interacting with NLK.
Shi Y, Ye K, Wu H, Sun Y, Shi H, Huo K
Mol Cell Biochem. 2010
PubMed ID: 19690946
Regulation of transforming growth factor-beta-dependent cyclooxygenase-2 expression in fibroblasts.
Matsumura T, Suzuki T, Aizawa K, Sawaki D, Munemasa Y, Ishida J, Nagai R
J Biol Chem. 2009
PubMed ID: 19837676
Traf2 interacts with Smad4 and regulates BMP signaling pathway in MC3T3-E1 osteoblasts.
Shimada K, Ikeda K, Ito K
Biochem Biophys Res Commun. 2009
PubMed ID: 19836350
Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation.
Herrera B, van Dinther M, Ten Dijke P, Inman GJ
Cancer Res. 2009
PubMed ID: 19996292
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation.
Azar R, Alard A, Susini C, Bousquet C, Pyronnet S
EMBO J. 2009
PubMed ID: 19834456
The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation.
Rajagopal R, Huang J, Dattilo LK, Kaartinen V, Mishina Y, Deng CX, Umans L, Zwijsen A, Roberts AB, Beebe DC
Dev Biol. 2009
PubMed ID: 19733164
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation.
Bornstein S, White R, Malkoski S, Oka M, Han G, Cleaver T, Reh D, Andersen P, Gross N, Olson S, Deng C, Lu SL, Wang XJ
J Clin Invest. 2009
PubMed ID: 19841536
Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions.
Conti FJ, Monkley SJ, Wood MR, Critchley DR, Müller U
Development. 2009
PubMed ID: 19793892
BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways.
Morikawa Y, Zehir A, Maska E, Deng C, Schneider MD, Mishina Y, Cserjesi P
Development. 2009
PubMed ID: 19793887
Free fatty acids enhance breast cancer cell migration through plasminogen activator inhibitor-1 and SMAD4.
Byon CH, Hardy RW, Ren C, Ponnazhagan S, Welch DR, McDonald JM, Chen Y
Lab Invest. 2009
PubMed ID: 19752858
Disruption of Smad4 in odontoblasts causes multiple keratocystic odontogenic tumors and tooth malformation in mice.
Gao Y, Yang G, Weng T, Du J, Wang X, Zhou J, Wang S, Yang X
Mol Cell Biol. 2009
PubMed ID: 19703995
Promoter-wide analysis of Smad4 binding sites in human epithelial cells.
Koinuma D, Tsutsumi S, Kamimura N, Imamura T, Aburatani H, Miyazono K
Cancer Sci. 2009
PubMed ID: 19686287
Strong Smad4 expression correlates with poor prognosis after surgery in patients with hepatocellular carcinoma.
Hiwatashi K, Ueno S, Sakoda M, Kubo F, Tateno T, Kurahara H, Mataki Y, Maemura K, Ishigami S, Shinchi H, Natsugoe S
Ann Surg Oncol. 2009
PubMed ID: 19626374
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
Nishiyama A, Xin L, Sharov AA, Thomas M, Mowrer G, Meyers E, Piao Y, Mehta S, Yee S, Nakatake Y, Stagg C, Sharova L, Correa-Cerro LS, Bassey U, Hoang H, Kim E, Tapnio R, Qian Y, Dudekula D, Zalzman M, Li M, Falco G, Yang HT, Lee SL, Monti M, Stanghellini I, Islam MN, Nagaraja R, Goldberg I, Wang W, Longo DL, Schlessinger D, Ko MS
Cell Stem Cell. 2009
PubMed ID: 19796622
Capn8 promoter directs the expression of Cre recombinase in gastric pit cells of transgenic mice.
Zhao Z, Sun Y, Hou N, Teng Y, Wang Y, Yang X
Genesis. 2009
PubMed ID: 19603510
Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines.
Nolting J, Daniel C, Reuter S, Stuelten C, Li P, Sucov H, Kim BG, Letterio JJ, Kretschmer K, Kim HJ, von Boehmer H
J Exp Med. 2009
PubMed ID: 19737861
The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, Pita G, Milne R, Maravall J, Ramos I, Andía V, Rodríguez-Poyo P, Jara-Albarrán A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Picó A, Pomares F, Giménez G, López-Mondéjar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodríguez-Antona C, González-Neira A, Matías-Guiu X, Santisteban P, Robledo M
PLoS Genet. 2009
PubMed ID: 19730683
Transforming growth factor-beta1 up-regulation of human alpha(1)(I) collagen is mediated by Sp1 and Smad2 transacting factors.
Sysa P, Potter JJ, Liu X, Mezey E
DNA Cell Biol. 2009
PubMed ID: 19558215
Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal.
Singh R, Horsthuis T, Farin HF, Grieskamp T, Norden J, Petry M, Wakker V, Moorman AF, Christoffels VM, Kispert A
Circ Res. 2009
PubMed ID: 19661464
Overexpression of bone morphogenetic protein 4 enhances the invasiveness of Smad4-deficient human colorectal cancer cells.
Deng H, Ravikumar TS, Yang WL
Cancer Lett. 2009
PubMed ID: 19321257
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition.
Vincent T, Neve EP, Johnson JR, Kukalev A, Rojo F, Albanell J, Pietras K, Virtanen I, Philipson L, Leopold PL, Crystal RG, de Herreros AG, Moustakas A, Pettersson RF, Fuxe J
Nat Cell Biol. 2009
PubMed ID: 19597490
Chondrocyte-specific Smad4 gene conditional knockout results in hearing loss and inner ear malformation in mice.
Yang SM, Hou ZH, Yang G, Zhang JS, Hu YY, Sun JH, Guo WW, He D, Han DY, Young WY, Yang X
Dev Dyn. 2009
PubMed ID: 19582869
SMAD-proteins as a molecular switch from hypertrophy to apoptosis induction in adult ventricular cardiomyocytes.
Heger J, Peters SC, Piper HM, Euler G
J Cell Physiol. 2009
PubMed ID: 19415695
Smad4/Smad7 balance: a role of tumorigenesis in gastric cancer.
Leng A, Liu T, He Y, Li Q, Zhang G
Exp Mol Pathol. 2009
PubMed ID: 19341727
SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer.
Blackford A, Serrano OK, Wolfgang CL, Parmigiani G, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Cameron JL, Olino K, Schulick R, Winter J, Herman JM, Laheru D, Klein AP, Vogelstein B, Kinzler KW, Velculescu VE, Hruban RH
Clin Cancer Res. 2009
PubMed ID: 19584151
A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.
Gaspar C, Franken P, Molenaar L, Breukel C, van der Valk M, Smits R, Fodde R
PLoS Genet. 2009
PubMed ID: 19578404
Pancreatic cancer: molecular pathogenesis and new therapeutic targets.
Wong HH, Lemoine NR
Nat Rev Gastroenterol Hepatol. 2009
PubMed ID: 19506583
Remodeling of chromatin structure within the promoter is important for bmp-2-induced fgfr3 expression.
Sun F, Chen Q, Yang S, Pan Q, Ma J, Wan Y, Chang CH, Hong A
Nucleic Acids Res. 2009
PubMed ID: 19401440
A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.
Fritzmann J, Morkel M, Besser D, Budczies J, Kosel F, Brembeck FH, Stein U, Fichtner I, Schlag PM, Birchmeier W
Gastroenterology. 2009
PubMed ID: 19328798
Dynamic signaling network for the specification of embryonic pancreas and liver progenitors.
Wandzioch E, Zaret KS
Science. 2009
PubMed ID: 19556507
Multiple lineage-specific roles of Smad4 during neural crest development.
Büchmann-Møller S, Miescher I, John N, Krishnan J, Deng CX, Sommer L
Dev Biol. 2009
PubMed ID: 19361496
iNKT cell development is orchestrated by different branches of TGF-beta signaling.
Doisne JM, Bartholin L, Yan KP, Garcia CN, Duarte N, Le Luduec JB, Vincent D, Cyprian F, Horvat B, Martel S, Rimokh R, Losson R, Benlagha K, Marie JC
J Exp Med. 2009
PubMed ID: 19451264
Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1.
Hsu LJ, Schultz L, Hong Q, Van Moer K, Heath J, Li MY, Lai FJ, Lin SR, Lee MH, Lo CP, Lin YS, Chen ST, Chang NS
J Biol Chem. 2009
PubMed ID: 19366691
The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ
PLoS Genet. 2009
PubMed ID: 19521500
Pediatric juvenile polyposis syndromes: an update.
Huang SC, Erdman SH
Curr Gastroenterol Rep. 2009
PubMed ID: 19463221
TNF-alpha suppressed TGF-beta-induced CTGF expression by switching the binding preference of p300 from Smad4 to p65.
Yu F, Chou CW, Chen CC
Cell Signal. 2009
PubMed ID: 19385047
Juvenile polyps have gastric differentiation with MUC5AC expression and downregulation of CDX2 and SMAD4.
Barros R, Mendes N, Howe JR, Reis CA, de Bolos C, Carneiro F, David L, Almeida R
Histochem Cell Biol. 2009
PubMed ID: 19266212
A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, for the MrOS Research Group
J Bone Miner Res. 2009
PubMed ID: 19453261
[Correlations of TGF-betaRII, Smad4 and Smad7 expression to clinicopathologic characteristics and prognosis of gastric cancer].
Lu B, Zhou YN, Li Q, Wu ZQ, Zhang ZY, Ji R, Guo QH, Liu W
Ai Zheng. 2009
PubMed ID: 19624886
[Analysis of K-ras, BRCA1/2, CHEK2 mutations and microsatellite markers (loss of heterozygosity at 9p, 17p and 18q) in sporadic pancreas adenocarcinomas]
Amosenko FA, Kazubskaia TP, Gromyko OE, Matveeva TI, Korchagina EL, Nasedkina TV, Gar'kavtseva RF, Kalinin VN
Mol Biol (Mosk). 2009
PubMed ID: 19548527
FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate.
Huang J, Dattilo LK, Rajagopal R, Liu Y, Kaartinen V, Mishina Y, Deng CX, Umans L, Zwijsen A, Roberts AB, Beebe DC
Development. 2009
PubMed ID: 19369394
Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma.
Brody JR, Costantino CL, Potoczek M, Cozzitorto J, McCue P, Yeo CJ, Hruban RH, Witkiewicz AK
Mod Pathol. 2009
PubMed ID: 19270646
A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension.
Shintani M, Yagi H, Nakayama T, Saji T, Matsuoka R
J Med Genet. 2009
PubMed ID: 19211612
miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1.
Lin EA, Kong L, Bai XH, Luan Y, Liu CJ
J Biol Chem. 2009
PubMed ID: 19251704
Genetic mutations associated with cigarette smoking in pancreatic cancer.
Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH
Cancer Res. 2009
PubMed ID: 19351817
DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.
Iacobuzio-Donahue CA, Fu B, Yachida S, Luo M, Abe H, Henderson CM, Vilardell F, Wang Z, Keller JW, Banerjee P, Herman JM, Cameron JL, Yeo CJ, Halushka MK, Eshleman JR, Raben M, Klein AP, Hruban RH, Hidalgo M, Laheru D
J Clin Oncol. 2009
PubMed ID: 19273710
Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli.
Huang H, Constante M, Layoun A, Santos MM
Blood. 2009
PubMed ID: 19204324
BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation.
Retting KN, Song B, Yoon BS, Lyons KM
Development. 2009
PubMed ID: 19224984
Smad4 restoration leads to a suppression of Wnt/beta-catenin signaling activity and migration capacity in human colon carcinoma cells.
Tian X, Du H, Fu X, Li K, Li A, Zhang Y
Biochem Biophys Res Commun. 2009
PubMed ID: 19284991
Association of v-ErbA with Smad4 disrupts TGF-beta signaling.
Erickson RA, Liu X
Mol Biol Cell. 2009
PubMed ID: 19144825
Clinical features and mutations in the ENG, ACVRL1, and SMAD4 genes in Korean patients with hereditary hemorrhagic telangiectasia.
Lee ST, Kim JA, Jang SY, Kim DK, Do YS, Suh GY, Kim JW, Ki CS
J Korean Med Sci. 2009
PubMed ID: 19270816
Bone morphogenetic protein-2 enhances Wnt/beta-catenin signaling-induced osteoprotegerin expression.
Sato MM, Nakashima A, Nashimoto M, Yawaka Y, Tamura M
Genes Cells. 2009
PubMed ID: 19170762
Disruption of Smad4 in mouse epidermis leads to depletion of follicle stem cells.
Yang L, Wang L, Yang X
Mol Biol Cell. 2009
PubMed ID: 19073883
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.
Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N, Argenton F, Newfeld SJ, Piccolo S
Cell. 2009
PubMed ID: 19135894
Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells.
Sharff KA, Song WX, Luo X, Tang N, Luo J, Chen J, Bi Y, He BC, Huang J, Li X, Jiang W, Zhu GH, Su Y, He Y, Shen J, Wang Y, Chen L, Zuo GW, Liu B, Pan X, Reid RR, Luu HH, Haydon RC, He TC
J Biol Chem. 2009
PubMed ID: 18986983
Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles.
Guo Y, Zhang X, Huang J, Zeng Y, Liu W, Geng C, Li KW, Yang D, Wu S, Wei H, Han Z, Qian X, Jiang Y, He F
PLoS One. 2009
PubMed ID: 19865483
Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development.
Costello I, Biondi CA, Taylor JM, Bikoff EK, Robertson EJ
BMC Dev Biol. 2009
PubMed ID: 19849841
Downregulation of SMAD2, 4 and 6 mRNA and TGFbeta receptor I mRNA in lesional and non-lesional psoriatic skin.
Yu H, Mrowietz U, Seifert O
Acta Derm Venereol. 2009
PubMed ID: 19688145
Regulation of TGF-beta signalling by Fbxo11, the gene mutated in the Jeff otitis media mouse mutant.
Tateossian H, Hardisty-Hughes RE, Morse S, Romero MR, Hilton H, Dean C, Brown SD
Pathogenetics. 2009
PubMed ID: 19580641
[Functional significance of TGF-beta1 signal transduction pathway in oral squamous cell carcinoma].
Wang XM, Liu CM, Zhang CR, Xu XG, Fu SB
Zhonghua Zhong Liu Za Zhi. 2009
PubMed ID: 19538865
Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas.
Nielsen M, de Miranda NF, van Puijenbroek M, Jordanova ES, Middeldorp A, van Wezel T, van Eijk R, Tops CM, Vasen HF, Hes FJ, Morreau H
BMC Cancer. 2009
PubMed ID: 19527492
Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5.
Tabata T, Kokura K, Ten Dijke P, Ishii S
Genes Cells. 2009
PubMed ID: 19032343
Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas.
Kitamura T, Biyajima K, Aoki M, Oshima M, Taketo MM
Lab Invest. 2009
PubMed ID: 19002110
Genetic and epigenetic alterations of familial pancreatic cancers.
Brune K, Hong SM, Li A, Yachida S, Abe T, Griffith M, Yang D, Omura N, Eshleman J, Canto M, Schulick R, Klein AP, Hruban RH, Iacobuzio-Donohue C, Goggins M
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064568
HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition.
Thuault S, Tan EJ, Peinado H, Cano A, Heldin CH, Moustakas A
J Biol Chem. 2008
PubMed ID: 18832382
Roles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes.
Wang B, Suzuki H, Kato M
Biochem Biophys Res Commun. 2008
PubMed ID: 18783722
BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4.
Furtado MB, Solloway MJ, Jones VJ, Costa MW, Biben C, Wolstein O, Preis JI, Sparrow DB, Saga Y, Dunwoodie SL, Robertson EJ, Tam PP, Harvey RP
Genes Dev. 2008
PubMed ID: 18981480
Lentiviral-mediated Smad4 RNAi induced anti-proliferation by p16 up-regulation and apoptosis by caspase 3 down-regulation in hepatoma SMMC-7721 cells.
Huang S, Zhang F, Miao L, Zhang H, Fan Z, Wang X, Ji G
Oncol Rep. 2008
PubMed ID: 18949401
MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA.
Kong W, Yang H, He L, Zhao JJ, Coppola D, Dalton WS, Cheng JQ
Mol Cell Biol. 2008
PubMed ID: 18794355
Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells.
Jeker LT, Barthlott T, Keller MP, Zuklys S, Hauri-Hohl M, Deng CX, Holländer GA
Blood. 2008
PubMed ID: 18695001
Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival.
Rajagopal R, Dattilo LK, Kaartinen V, Deng CX, Umans L, Zwijsen A, Roberts AB, Bottinger EP, Beebe DC
Invest Ophthalmol Vis Sci. 2008
PubMed ID: 18566469
Inhibition of pancreatic carcinoma cell growth in vitro by DPC4 gene transfection.
Shen W, Tao GQ, Li DC, Zhu XG, Bai X, Cai B
World J Gastroenterol. 2008
PubMed ID: 18985820
Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.
Landry J, Sharov AA, Piao Y, Sharova LV, Xiao H, Southon E, Matta J, Tessarollo L, Zhang YE, Ko MS, Kuehn MR, Yamaguchi TP, Wu C
PLoS Genet. 2008
PubMed ID: 18974875
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity.
Owens P, Bazzi H, Engelking E, Han G, Christiano AM, Wang XJ
Dev Biol. 2008
PubMed ID: 18692037
Deleted in pancreatic carcinoma locus 4/Smad4 participates in the regulation of apoptosis by affecting the Bcl-2/Bax balance in non-small cell lung cancer.
Ke Z, Zhang X, Ma L, Wang L
Hum Pathol. 2008
PubMed ID: 18620728
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.
Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW
Science. 2008
PubMed ID: 18772397
The rate of germline mutations and large deletions of SMAD4 and BMPR1A in juvenile polyposis.
Calva-Cerqueira D, Chinnathambi S, Pechman B, Bair J, Larsen-Haidle J, Howe J
Clin Genet. 2008
PubMed ID: 18823382
Collagen1alpha1 promoter drives the expression of Cre recombinase in osteoblasts of transgenic mice.
Zha L, Hou N, Wang J, Yang G, Gao Y, Chen L, Yang X
J Genet Genomics. 2008
PubMed ID: 18804071
Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506.
Akool el-S, Doller A, Babelova A, Tsalastra W, Moreth K, Schaefer L, Pfeilschifter J, Eberhardt W
J Immunol. 2008
PubMed ID: 18684975
Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx2.1 and Pten.
Xing Y, Li C, Hu L, Tiozzo C, Li M, Chai Y, Bellusci S, Anderson S, Minoo P
Dev Biol. 2008
PubMed ID: 18602626
Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver.
Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, Wang RH, Deng C, Vaulont S, Mosser J, Coppin H, Roth MP
Blood. 2008
PubMed ID: 18539898
Preferential utilization of Imp7/8 in nuclear import of Smads.
Yao X, Chen X, Cottonham C, Xu L
J Biol Chem. 2008
PubMed ID: 18519565
Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development.
Xu X, Han J, Ito Y, Bringas P, Deng C, Chai Y
Dev Cell. 2008
PubMed ID: 18694570
Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression.
Hoot KE, Lighthall J, Han G, Lu SL, Li A, Ju W, Kulesz-Martin M, Bottinger E, Wang XJ
J Clin Invest. 2008
PubMed ID: 18618014
TGFbeta in Cancer.
Massagué J
Cell. 2008
PubMed ID: 18662538
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs.
Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS, Watowich SS, Feng XH, Jetten AM, Dong C
Immunity. 2008
PubMed ID: 18585065
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.
Varelas X, Sakuma R, Samavarchi-Tehrani P, Peerani R, Rao BM, Dembowy J, Yaffe MB, Zandstra PW, Wrana JL
Nat Cell Biol. 2008
PubMed ID: 18568018
Expression of Smad2 and Smad4 in cervical cancer: absent nuclear Smad4 expression correlates with poor survival.
Kloth JN, Kenter GG, Spijker HS, Uljee S, Corver WE, Jordanova ES, Fleuren GJ, Gorter A
Mod Pathol. 2008
PubMed ID: 18425078
Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells.
Zhao S, Venkatasubbarao K, Lazor JW, Sperry J, Jin C, Cao L, Freeman JW
Cancer Res. 2008
PubMed ID: 18519681
The up-regulation of 14-3-3 proteins in Smad4 deficient epidermis and hair follicles at catagen.
Yuan C, Jiao L, Yang L, Ying W, Hu Z, Liu J, Cui F, Li L, Qian L, Teng Y, Hang H, Qian X, Yang X
Proteomics. 2008
PubMed ID: 18446800
Growth-dependent repression of human adenine nucleotide translocator-2 (ANT2) transcription: evidence for the participation of Smad and Sp family proteins in the NF1-dependent repressor complex.
Luciakova K, Kollarovic G, Barath P, Nelson BD
Biochem J. 2008
PubMed ID: 18215124
The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers.
Kodach LL, Wiercinska E, de Miranda NF, Bleuming SA, Musler AR, Peppelenbosch MP, Dekker E, van den Brink GR, van Noesel CJ, Morreau H, Hommes DW, Ten Dijke P, Offerhaus GJ, Hardwick JC
Gastroenterology. 2008
PubMed ID: 18471510
Transforming growth factor-beta-regulated miR-24 promotes skeletal muscle differentiation.
Sun Q, Zhang Y, Yang G, Chen X, Zhang Y, Cao G, Wang J, Sun Y, Zhang P, Fan M, Shao N, Yang X
Nucleic Acids Res. 2008
PubMed ID: 18353861
Ubc9 promotes the stability of Smad4 and the nuclear accumulation of Smad1 in osteoblast-like Saos-2 cells.
Shimada K, Suzuki N, Ono Y, Tanaka K, Maeno M, Ito K
Bone. 2008
PubMed ID: 18321803
Functional blockade of Smad4 leads to a decrease in beta-catenin levels and signaling activity in human pancreatic carcinoma cells.
Romero D, Iglesias M, Vary CP, Quintanilla M
Carcinogenesis. 2008
PubMed ID: 18310088
Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer.
Aitchison AA, Veerakumarasivam A, Vias M, Kumar R, Hamdy FC, Neal DE, Mills IG
Prostate. 2008
PubMed ID: 18213629
Large genomic deletions of SMAD4, BMPR1A and PTEN in juvenile polyposis.
van Hattem WA, Brosens LA, de Leng WW, Morsink FH, Lens S, Carvalho R, Giardiello FM, Offerhaus GJ
Gut. 2008
PubMed ID: 18178612
Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells.
Zhao S, Ammanamanchi S, Brattain M, Cao L, Thangasamy A, Wang J, Freeman JW
J Biol Chem. 2008
PubMed ID: 18310076
Genetic variation in the inhibin pathway and risk of testicular germ cell tumors.
Purdue MP, Graubard BI, Chanock SJ, Rubertone MV, Erickson RL, McGlynn KA
Cancer Res. 2008
PubMed ID: 18413775
Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects.
Nie X, Deng CX, Wang Q, Jiao K
Dev Biol. 2008
PubMed ID: 18334251
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Transforming growth factor-beta1 decreases epithelial sodium channel functionality in renal collecting duct cells via a Smad4-dependent pathway.
Chang CT, Hung CC, Chen YC, Yen TH, Wu MS, Yang CW, Phillips A, Tian YC
Nephrol Dial Transplant. 2008
PubMed ID: 18045816
Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression.
Wilkinson DS, Tsai WW, Schumacher MA, Barton MC
Mol Cell Biol. 2008
PubMed ID: 18212064
Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins.
Thackray VG, Mellon PL
Endocrinology. 2008
PubMed ID: 18079204
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation.
Descargues P, Sil AK, Sano Y, Korchynskyi O, Han G, Owens P, Wang XJ, Karin M
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18268325
[Hematopoiesis is normally maintained in osteoblast-specific Smad4 gene knockout mice]
Lan Y, Tan XH, Weng TJ, Liu B, Yang X
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008
PubMed ID: 18315922
Smad signaling antagonizes STAT5-mediated gene transcription and mammary epithelial cell differentiation.
Cocolakis E, Dai M, Drevet L, Ho J, Haines E, Ali S, Lebrun JJ
J Biol Chem. 2008
PubMed ID: 18024957
Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells.
Colak D, Mori T, Brill MS, Pfeifer A, Falk S, Deng C, Monteiro R, Mummery C, Sommer L, Götz M
J Neurosci. 2008
PubMed ID: 18184786
Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors.
Liu Y, Yang FC, Okuda T, Dong X, Zylka MJ, Chen CL, Anderson DJ, Kuner R, Ma Q
J Neurosci. 2008
PubMed ID: 18171930
Divergent mechanisms underlie Smad4-mediated positive regulation of the three genes encoding the basement membrane component laminin-332 (laminin-5).
Zboralski D, Böckmann M, Zapatka M, Hoppe S, Schöneck A, Hahn SA, Schmiegel W, Schwarte-Waldhoff I
BMC Cancer. 2008
PubMed ID: 18664273
Expression of DPC4/Smad4 in non-small-cell lung carcinoma and its relationship with angiogenesis.
Ke Z, Zhang X, Ma L, Wang L
Neoplasma. 2008
PubMed ID: 18505344
Promiscuous recombination of LoxP alleles during gametogenesis in cornea Cre driver mice.
Weng DY, Zhang Y, Hayashi Y, Kuan CY, Liu CY, Babcock G, Weng WL, Schwemberger S, Kao WW
Mol Vis. 2008
PubMed ID: 18385792
TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs.
Alejandre-Alcázar MA, Michiels-Corsten M, Vicencio AG, Reiss I, Ryu J, de Krijger RR, Haddad GG, Tibboel D, Seeger W, Eickelberg O, Morty RE
Dev Dyn. 2008
PubMed ID: 18095342
Dynamic analysis of the expression of the TGFbeta/SMAD2 pathway and CCN2/CTGF during early steps of tooth development.
Pacheco MS, Reis AH, Aguiar DP, Lyons KM, Abreu JG
Cells Tissues Organs. 2008
PubMed ID: 18089935
SMAD expression in the testis: an insight into BMP regulation of spermatogenesis.
Itman C, Loveland KL
Dev Dyn. 2008
PubMed ID: 18069690
Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells.
Durand C, Robin C, Bollerot K, Baron MH, Ottersbach K, Dzierzak E
Proc Natl Acad Sci U S A. 2007
PubMed ID: 18087045
Novel mutations in Smad proteins that inhibit signaling by the transforming growth factor beta in mammalian cells.
Prokova V, Mavridou S, Papakosta P, Petratos K, Kardassis D
Biochemistry. 2007
PubMed ID: 17994767
Smad4 is required to regulate the fate of cranial neural crest cells.
Ko SO, Chung IH, Xu X, Oka S, Zhao H, Cho ES, Deng C, Chai Y
Dev Biol. 2007
PubMed ID: 17964566
Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II.
Kalo E, Buganim Y, Shapira KE, Besserglick H, Goldfinger N, Weisz L, Stambolsky P, Henis YI, Rotter V
Mol Cell Biol. 2007
PubMed ID: 17875924
Smad signaling in the neural crest regulates cardiac outflow tract remodeling through cell autonomous and non-cell autonomous effects.
Jia Q, McDill BW, Li SZ, Deng C, Chang CP, Chen F
Dev Biol. 2007
PubMed ID: 17916348
High proportion of large genomic deletions and a genotype phenotype update in 80 unrelated families with juvenile polyposis syndrome.
Aretz S, Stienen D, Uhlhaas S, Stolte M, Entius MM, Loff S, Back W, Kaufmann A, Keller KM, Blaas SH, Siebert R, Vogt S, Spranger S, Holinski-Feder E, Sunde L, Propping P, Friedl W
J Med Genet. 2007
PubMed ID: 17873119
Essential role of Smad4 in maintaining cardiomyocyte proliferation during murine embryonic heart development.
Qi X, Yang G, Yang L, Lan Y, Weng T, Wang J, Wu Z, Xu J, Gao X, Yang X
Dev Biol. 2007
PubMed ID: 17869237
Essential role of endothelial Smad4 in vascular remodeling and integrity.
Lan Y, Liu B, Yao H, Li F, Weng T, Yang G, Li W, Cheng X, Mao N, Yang X
Mol Cell Biol. 2007
PubMed ID: 17724086
Normal erythropoiesis but severe polyposis and bleeding anemia in Smad4-deficient mice.
Pan D, Schomber T, Kalberer CP, Terracciano LM, Hafen K, Krenger W, Hao-Shen H, Deng C, Skoda RC
Blood. 2007
PubMed ID: 17638848
The utility of SMAD4 as a diagnostic immunohistochemical marker for pancreatic adenocarcinoma, and its expression in other solid tumors.
Ali S, Cohen C, Little JV, Sequeira JH, Mosunjac MB, Siddiqui MT
Diagn Cytopathol. 2007
PubMed ID: 17854080
Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance.
Milet J, Dehais V, Bourgain C, Jouanolle AM, Mosser A, Perrin M, Morcet J, Brissot P, David V, Deugnier Y, Mosser J
Am J Hum Genet. 2007
PubMed ID: 17847004
Temporal and spatial regulation of bone morphogenetic protein signaling in late lung development.
Alejandre-Alcázar MA, Shalamanov PD, Amarie OV, Sevilla-Pérez J, Seeger W, Eickelberg O, Morty RE
Dev Dyn. 2007
PubMed ID: 17823941
Smad4-independent, PP2A-dependent apoptotic effect of exogenous transforming growth factor beta 1 in lymphoma cells.
Sebestyén A, Hajdu M, Kis L, Barna G, Kopper L
Exp Cell Res. 2007
PubMed ID: 17643425
Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia.
Kojima K, Vickers SM, Adsay NV, Jhala NC, Kim HG, Schoeb TR, Grizzle WE, Klug CA
Cancer Res. 2007
PubMed ID: 17804724
TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways.
Martin MM, Buckenberger JA, Jiang J, Malana GE, Knoell DL, Feldman DS, Elton TS
Am J Physiol Lung Cell Mol Physiol. 2007
PubMed ID: 17601799
Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.
Levy L, Howell M, Das D, Harkin S, Episkopou V, Hill CS
Mol Cell Biol. 2007
PubMed ID: 17591695
Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps.
Hodge LK, Klassen MP, Han BX, Yiu G, Hurrell J, Howell A, Rousseau G, Lemaigre F, Tessier-Lavigne M, Wang F
Neuron. 2007
PubMed ID: 17698011
Myocardial smad4 is essential for cardiogenesis in mouse embryos.
Song L, Yan W, Chen X, Deng CX, Wang Q, Jiao K
Circ Res. 2007
PubMed ID: 17585069
Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells.
Grijelmo C, Rodrigue C, Svrcek M, Bruyneel E, Hendrix A, de Wever O, Gespach C
Cell Signal. 2007
PubMed ID: 17478078
Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer.
Salek C, Benesova L, Zavoral M, Nosek V, Kasperova L, Ryska M, Strnad R, Traboulsi E, Minarik M
World J Gastroenterol. 2007
PubMed ID: 17659731
Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development.
Izzi L, Silvestri C, von Both I, Labbé E, Zakin L, Wrana JL, Attisano L
EMBO J. 2007
PubMed ID: 17568773
Smad4 is required for maintaining normal murine postnatal bone homeostasis.
Tan X, Weng T, Zhang J, Wang J, Li W, Wan H, Lan Y, Cheng X, Hou N, Liu H, Ding J, Lin F, Yang R, Gao X, Chen D, Yang X
J Cell Sci. 2007
PubMed ID: 17550966
Involvement of deterioration in S100C/A11-mediated pathway in resistance of human squamous cancer cell lines to TGFbeta-induced growth suppression.
Sonegawa H, Nukui T, Li DW, Takaishi M, Sakaguchi M, Huh NH
J Mol Med. 2007
PubMed ID: 17476473
Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype.
Simirskii VN, Wang Y, Duncan MK
Dev Biol. 2007
PubMed ID: 17493607
The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells.
Sheikh AA, Vimalachandran D, Thompson CC, Jenkins RE, Nedjadi T, Shekouh A, Campbell F, Dodson A, Prime W, Crnogorac-Jurcevic T, Lemoine NR, Costello E
Proteomics. 2007
PubMed ID: 17469085
Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation.
Zhang S, Fei T, Zhang L, Zhang R, Chen F, Ning Y, Han Y, Feng XH, Meng A, Chen YG
Mol Cell Biol. 2007
PubMed ID: 17438144
Cx43 mediates TGF-beta signaling through competitive Smads binding to microtubules.
Dai P, Nakagami T, Tanaka H, Hitomi T, Takamatsu T
Mol Biol Cell. 2007
PubMed ID: 17429065
Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling.
Biondi CA, Das D, Howell M, Islam A, Bikoff EK, Hill CS, Robertson EJ
Biochem J. 2007
PubMed ID: 17300215
Dual transcriptional control of claudin-11 via an overlapping GATA/NF-Y motif: positive regulation through the interaction of GATA, NF-YA, and CREB and negative regulation through the interaction of Smad, HDAC1, and mSin3A.
Lui WY, Wong EW, Guan Y, Lee WM
J Cell Physiol. 2007
PubMed ID: 17226765
Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts.
Jinnin M, Ihn H, Mimura Y, Asano Y, Tamaki K
Arthritis Rheum. 2007
PubMed ID: 17469184
TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex.
Nawshad A, Medici D, Liu CC, Hay ED
J Cell Sci. 2007
PubMed ID: 17452626
Loss of Smad4 expression predicts liver metastasis in human colorectal cancer.
Losi L, Bouzourene H, Benhattar J
Oncol Rep. 2007
PubMed ID: 17390050
Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension.
Morty RE, Nejman B, Kwapiszewska G, Hecker M, Zakrzewicz A, Kouri FM, Peters DM, Dumitrascu R, Seeger W, Knaus P, Schermuly RT, Eickelberg O
Arterioscler Thromb Vasc Biol. 2007
PubMed ID: 17347486
Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.
Rossi SW, Jeker LT, Ueno T, Kuse S, Keller MP, Zuklys S, Gudkov AV, Takahama Y, Krenger W, Blazar BR, Holländer GA
Blood. 2007
PubMed ID: 17213286
3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins.
Seong HA, Jung H, Kim KT, Ha H
J Biol Chem. 2007
PubMed ID: 17327236
TGF-beta signaling alterations and susceptibility to colorectal cancer.
Xu Y, Pasche B
Hum Mol Genet. 2007
PubMed ID: 17613544
K-ras and Dpc4 mutations in chronic pancreatitis: case series.
Popović Hadzija M, Korolija M, Jakić Razumović J, Pavković P, Hadzija M, Kapitanović S
Croat Med J. 2007
PubMed ID: 17436386
SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion.
Kitamura T, Kometani K, Hashida H, Matsunaga A, Miyoshi H, Hosogi H, Aoki M, Oshima M, Hattori M, Takabayashi A, Minato N, Taketo MM
Nat Genet. 2007
PubMed ID: 17369830
Smad4 is critical for self-renewal of hematopoietic stem cells.
Karlsson G, Blank U, Moody JL, Ehinger M, Singbrant S, Deng CX, Karlsson S
J Exp Med. 2007
PubMed ID: 17353364
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas.
Izeradjene K, Combs C, Best M, Gopinathan A, Wagner A, Grady WM, Deng CX, Hruban RH, Adsay NV, Tuveson DA, Hingorani SR
Cancer Cell. 2007
PubMed ID: 17349581
Smad4 is essential for down-regulation of E-cadherin induced by TGF-beta in pancreatic cancer cell line PANC-1.
Takano S, Kanai F, Jazag A, Ijichi H, Yao J, Ogawa H, Enomoto N, Omata M, Nakao A
J Biochem. 2007
PubMed ID: 17301079
Localization of TGF-beta signaling intermediates Smad2, 3, 4, and 7 in developing and mature human and mouse kidney.
Banas MC, Parks WT, Hudkins KL, Banas B, Holdren M, Iyoda M, Wietecha TA, Kowalewska J, Liu G, Alpers CE
J Histochem Cytochem. 2007
PubMed ID: 17142805
Basement membrane component laminin-5 is a target of the tumor suppressor Smad4.
Zapatka M, Zboralski D, Radacz Y, Böckmann M, Arnold C, Schöneck A, Hoppe S, Tannapfel A, Schmiegel W, Simon-Assmann P, Schwarte-Waldhoff I
Oncogene. 2007
PubMed ID: 16953227
Disruption of transforming growth factor beta-Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4.
Qiu W, Schönleben F, Li X, Su GH
Cancer Lett. 2007
PubMed ID: 16478646
High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition.
Klein-Scory S, Zapatka M, Eilert-Micus C, Hoppe S, Schwarz E, Schmiegel W, Hahn SA, Schwarte-Waldhoff I
BMC Cancer. 2007
PubMed ID: 17997817
Inactivation of SMAD4 tumor suppressor gene during gastric carcinoma progression.
Wang LH, Kim SH, Lee JH, Choi YL, Kim YC, Park TS, Hong YC, Wu CF, Shin YK
Clin Cancer Res. 2007
PubMed ID: 17200344
Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development.
Singh S, Yin X, Pisano MM, Greene RM
Birth Defects Res A Clin Mol Teratol. 2007
PubMed ID: 17177285
Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons.
Zhang J, Pho V, Bonasera SJ, Holtzman J, Tang AT, Hellmuth J, Tang S, Janak PH, Tecott LH, Huang EJ
Nat Neurosci. 2007
PubMed ID: 17159989
Surfactant protein A promoter directs the expression of Cre recombinase in brain microvascular endothelial cells of transgenic mice.
Meng F, Shi L, Cheng X, Hou N, Wang Y, Teng Y, Meng A, Yang X
Matrix Biol. 2007
PubMed ID: 17059883
Smad4 cooperates with lymphoid enhancer-binding factor 1/T cell-specific factor to increase c-myc expression in the absence of TGF-beta signaling.
Lim SK, Hoffmann FM
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17132729
A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models.
Tesseur I, Wyss-Coray T
Curr Alzheimer Res. 2006
PubMed ID: 17168649
Effect of DPC4 gene on invasion and metastasis of colorectal carcinoma cells.
Xiao DS, Wen JF, Li JH, Wang KS, Hu ZL, Zhou JH, Deng ZH, Liu Y
Acta Biochim Biophys Sin (Shanghai). 2006
PubMed ID: 17151782
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.
Weskamp G, Ford JW, Sturgill J, Martin S, Docherty AJ, Swendeman S, Broadway N, Hartmann D, Saftig P, Umland S, Sehara-Fujisawa A, Black RA, Ludwig A, Becherer JD, Conrad DH, Blobel CP
Nat Immunol. 2006
PubMed ID: 17072319
cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts.
Liu X, Sun SQ, Hassid A, Ostrom RS
Mol Pharmacol. 2006
PubMed ID: 16959941
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.
Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA
Genes Dev. 2006
PubMed ID: 17114584
Regulation of Smad activities.
Xu L
Biochim Biophys Acta. 2006
PubMed ID: 17182123
Differential proteome analysis of colon carcinoma cell line SW480 after reconstitution of the tumour suppressor Smad4.
Stühler K, Köper K, Pfeiffer K, Tagariello A, Souquet M, Schwarte-Waldhoff I, Hahn SA, Schmiegel W, Meyer HE
Anal Bioanal Chem. 2006
PubMed ID: 17043799
Effects of RNAi-mediated Smad4 silencing on growth and apoptosis of human rhabdomyosarcoma cells.
Ye L, Zhang H, Zhang L, Yang G, Ke Q, Guo H, Bu H
Int J Oncol. 2006
PubMed ID: 17016646
The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
Science. 2006
PubMed ID: 16959974
SMAD4 mutations found in unselected HHT patients.
Gallione CJ, Richards JA, Letteboer TG, Rushlow D, Prigoda NL, Leedom TP, Ganguly A, Castells A, Ploos van Amstel JK, Westermann CJ, Pyeritz RE, Marchuk DA
J Med Genet. 2006
PubMed ID: 16613914
Expression and mutation of SMAD4 in poorly differentiated carcinoma and signet-ring cell carcinoma of the colorectum.
Seshimo I, Yamamoto H, Mishima H, Kurata A, Suzuki R, Ezumi K, Takemasa I, Ikeda M, Fukushima T, Tsujinaka T, Sekimoto M, Kikkawa N, Takenoshita S, Monden M
J Exp Clin Cancer Res. 2006
PubMed ID: 17167985
Expression of inhibin-activin subunits, follistatin and smads in granulosa-luteal cells collected at oocyte retrieval.
Chang SY, Kang HY, Lan KC, Hseh CY, Huang FJ, Huang KE
J Assist Reprod Genet. 2006
PubMed ID: 17053951
Aberrant expression of Smad4, a TGF-beta signaling molecule, in oral squamous cell carcinoma.
Iamaroon A, Pattamapun K, Piboonniyom SO
J Oral Sci. 2006
PubMed ID: 17023741
C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells.
Gomis RR, Alarcón C, Nadal C, Van Poznak C, Massagué J
Cancer Cell. 2006
PubMed ID: 16959612
Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-beta signaling in ovarian cancer.
Sunde JS, Donninger H, Wu K, Johnson ME, Pestell RG, Rose GS, Mok SC, Brady J, Bonome T, Birrer MJ
Cancer Res. 2006
PubMed ID: 16951150
Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation.
Park C, Lavine K, Mishina Y, Deng CX, Ornitz DM, Choi K
Development. 2006
PubMed ID: 16887829
Acute myelogenous leukemia-derived SMAD4 mutations target the protein to ubiquitin-proteasome degradation.
Yang L, Wang N, Tang Y, Cao X, Wan M
Hum Mutat. 2006
PubMed ID: 16865698
The transforming growth factor-beta-Smad3/4 signaling pathway acts as a positive regulator for TLR2 induction by bacteria via a dual mechanism involving functional cooperation with NF-kappaB and MAPK phosphatase 1-dependent negative cross-talk with p38 MA
Mikami F, Lim JH, Ishinaga H, Ha UH, Gu H, Koga T, Jono H, Kai H, Li JD
J Biol Chem. 2006
PubMed ID: 16754688
Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity.
Xiong B, Rui Y, Zhang M, Shi K, Jia S, Tian T, Yin K, Huang H, Lin S, Zhao X, Chen Y, Chen YG, Lin SC, Meng A
Dev Cell. 2006
PubMed ID: 16890162
Synergistic function of Smad4 and PTEN in suppressing forestomach squamous cell carcinoma in the mouse.
Teng Y, Sun AN, Pan XC, Yang G, Yang LL, Wang MR, Yang X
Cancer Res. 2006
PubMed ID: 16849541
Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.
Xu X, Kobayashi S, Qiao W, Li C, Xiao C, Radaeva S, Stiles B, Wang RH, Ohara N, Yoshino T, LeRoith D, Torbenson MS, Gores GJ, Wu H, Gao B, Deng CX
J Clin Invest. 2006
PubMed ID: 16767220
Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon cancer cells.
Grau AM, Datta PK, Zi J, Halder SK, Beauchamp RD
Cell Signal. 2006
PubMed ID: 16288847
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.
Kim BG, Li C, Qiao W, Mamura M, Kasprzak B, Kasperczak B, Anver M, Wolfraim L, Hong S, Mushinski E, Potter M, Kim SJ, Fu XY, Deng C, Letterio JJ
Nature. 2006
PubMed ID: 16791201
TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF.
Kim SS, Shetty K, Katuri V, Kitisin K, Baek HJ, Tang Y, Marshall B, Johnson L, Mishra B, Mishra L
Biochem Biophys Res Commun. 2006
PubMed ID: 16650383
Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.
He W, Dorn DC, Erdjument-Bromage H, Tempst P, Moore MA, Massagué J
Cell. 2006
PubMed ID: 16751102
[Smad4 and TGF-beta1 expression and clinical significance in bladder transitional cell carcinoma].
Tang ZY, Yang LY, Zhang YJ, Peng KL, Qi L
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006
PubMed ID: 16859125
Homozygous deletion of SMAD4 in breast cancer cell lines and invasive ductal carcinomas.
Zhong D, Morikawa A, Guo L, Colpaert C, Xiong L, Nassar A, Chen C, Lamb N, Dong JT, Zhou W
Cancer Biol Ther. 2006
PubMed ID: 16627986
Premature luteinization and cumulus cell defects in ovarian-specific Smad4 knockout mice.
Pangas SA, Li X, Robertson EJ, Matzuk MM
Mol Endocrinol. 2006
PubMed ID: 16513794
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Inhibins are the major activin ligands expressed during early thymocyte development.
Licona P, Chimal-Monroy J, Soldevila G
Dev Dyn. 2006
PubMed ID: 16477644
Critical interactions between TGF-beta signaling/ELF, and E-cadherin/beta-catenin mediated tumor suppression.
Katuri V, Tang Y, Li C, Jogunoori W, Deng CX, Rashid A, Sidawy AN, Evans S, Reddy EP, Mishra B, Mishra L
Oncogene. 2006
PubMed ID: 16288220
Smad4 haploinsufficiency in mouse models for intestinal cancer.
Alberici P, Jagmohan-Changur S, De Pater E, Van Der Valk M, Smits R, Hohenstein P, Fodde R
Oncogene. 2006
PubMed ID: 16288217
Expression and location of Smad2, 4 mRNAs during and after liver fibrogenesis of rats.
Liu Y, Wang LF, Zou HF, Song XY, Xu HF, Lin P, Zheng HH, Yu XG
World J Gastroenterol. 2006
PubMed ID: 16570350
A novel mouse Smad4 mutation reduces protein stability and wild-type protein levels.
Chen Y, Yee D, Magnuson T
Mamm Genome. 2006
PubMed ID: 16518688
Mutation screening in juvenile polyposis syndrome.
Pyatt RE, Pilarski R, Prior TW
J Mol Diagn. 2006
PubMed ID: 16436638
Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin.
Qiao W, Li AG, Owens P, Xu X, Wang XJ, Deng CX
Oncogene. 2006
PubMed ID: 16170355
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation.
Song K, Wang H, Krebs TL, Danielpour D
EMBO J. 2006
PubMed ID: 16362038
Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS.
Sun Y, Ding L, Zhang H, Han J, Yang X, Yan J, Zhu Y, Li J, Song H, Ye Q
Nucleic Acids Res. 2006
PubMed ID: 17099224
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Bone morphogenetic protein-4 inhibits corticotroph tumor cells: involvement in the retinoic acid inhibitory action.
Giacomini D, Páez-Pereda M, Theodoropoulou M, Labeur M, Refojo D, Gerez J, Chervin A, Berner S, Losa M, Buchfelder M, Renner U, Stalla GK, Arzt E
Endocrinology. 2006
PubMed ID: 16195406
Involvement of SMAD4, but not of SMAD2, in transforming growth factor-beta1-induced trophoblast expression of matrix metalloproteinase-2.
Lin HY, Yang Q, Wang HM, Qi JG, Zhang H, Wang HX, Tsang BK, Zhu C
Front Biosci. 2006
PubMed ID: 16146757
Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements.
Kantola AK, Keski-Oja J, Koli K
Gene. 2005
PubMed ID: 16223572
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.
Wang RH, Li C, Xu X, Zheng Y, Xiao C, Zerfas P, Cooperman S, Eckhaus M, Rouault T, Mishra L, Deng CX
Cell Metab. 2005
PubMed ID: 16330325
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure.
Wang J, Xu N, Feng X, Hou N, Zhang J, Cheng X, Chen Y, Zhang Y, Yang X
Circ Res. 2005
PubMed ID: 16151019
Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors.
Yang L, Mao C, Teng Y, Li W, Zhang J, Cheng X, Li X, Han X, Xia Z, Deng H, Yang X
Cancer Res. 2005
PubMed ID: 16204035
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway.
Kang Y, He W, Tulley S, Gupta GP, Serganova I, Chen CR, Manova-Todorova K, Blasberg R, Gerald WL, Massagué J
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16172383
DNA sequence and analysis of human chromosome 18.
Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES
Nature. 2005
PubMed ID: 16177791
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Endothelial cell-specific expression of Cre recombinase in transgenic mice.
Li WL, Cheng X, Tan XH, Zhang JS, Sun YS, Chen L, Yang X
Yi Chuan Xue Bao. 2005
PubMed ID: 16201233
Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses.
Levy L, Hill CS
Mol Cell Biol. 2005
PubMed ID: 16135802
Colocalization of mouse autoimmune diabetes loci Idd21.1 and Idd21.2 with IDDM6 (human) and Iddm3 (rat).
Hollis-Moffatt JE, Hook SM, Merriman TR
Diabetes. 2005
PubMed ID: 16123376
Smad4 is required for the normal organization of the cartilage growth plate.
Zhang J, Tan X, Li W, Wang Y, Wang J, Cheng X, Yang X
Dev Biol. 2005
PubMed ID: 16023633
Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling.
Sun Y, Lowther W, Kato K, Bianco C, Kenney N, Strizzi L, Raafat D, Hirota M, Khan NI, Bargo S, Jones B, Salomon D, Callahan R
Oncogene. 2005
PubMed ID: 16007227
A complex pattern of mutations and abnormal splicing of Smad4 is present in thyroid tumours.
Lazzereschi D, Nardi F, Turco A, Ottini L, D'Amico C, Mariani-Costantini R, Gulino A, Coppa A
Oncogene. 2005
PubMed ID: 15940269
Determinants of trophoblast lineage and cell subtype specification in the mouse placenta.
Simmons DG, Cross JC
Dev Biol. 2005
PubMed ID: 15963972
Smad4 inhibits tumor growth by inducing apoptosis in estrogen receptor-alpha-positive breast cancer cells.
Li Q, Wu L, Oelschlager DK, Wan M, Stockard CR, Grizzle WE, Wang N, Chen H, Sun Y, Cao X
J Biol Chem. 2005
PubMed ID: 15886208
Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas.
Ando T, Sugai T, Habano W, Jiao YF, Suzuki K
J Gastroenterol. 2005
PubMed ID: 16082587
Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo.
Hartwig S, Hu MC, Cella C, Piscione T, Filmus J, Rosenblum ND
Mech Dev. 2005
PubMed ID: 15925496
Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1.
Alliston T, Ko TC, Cao Y, Liang YY, Feng XH, Chang C, Derynck R
J Biol Chem. 2005
PubMed ID: 15849193
Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases.
Morén A, Imamura T, Miyazono K, Heldin CH, Moustakas A
J Biol Chem. 2005
PubMed ID: 15817471
Nuclear targeting of transforming growth factor-beta-activated Smad complexes.
Chen HB, Rud JG, Lin K, Xu L
J Biol Chem. 2005
PubMed ID: 15799969
Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum.
Pizard A, Burgon PG, Paul DL, Bruneau BG, Seidman CE, Seidman JG
Mol Cell Biol. 2005
PubMed ID: 15923624
CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation.
Xin H, Xu X, Li L, Ning H, Rong Y, Shang Y, Wang Y, Fu XY, Chang Z
J Biol Chem. 2005
PubMed ID: 15781469
Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism.
Rodríguez-Vita J, Sánchez-López E, Esteban V, Rupérez M, Egido J, Ruiz-Ortega M
Circulation. 2005
PubMed ID: 15883213
Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis.
Tang Y, Katuri V, Srinivasan R, Fogt F, Redman R, Anand G, Said A, Fishbein T, Zasloff M, Reddy EP, Mishra B, Mishra L
Cancer Res. 2005
PubMed ID: 15899814
Differences in Smad4 expression in human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck squamous cell carcinoma.
Báez A, Cantor A, Fonseca S, Marcos-Martinez M, Mathews LA, Muro-Cacho CA, Muñoz-Antonia T
Clin Cancer Res. 2005
PubMed ID: 15867212
SCF(beta-TrCP1) controls Smad4 protein stability in pancreatic cancer cells.
Wan M, Huang J, Jhala NC, Tytler EM, Yang L, Vickers SM, Tang Y, Lu C, Wang N, Cao X
Am J Pathol. 2005
PubMed ID: 15855639
Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy.
Embuscado EE, Laheru D, Ricci F, Yun KJ, de Boom Witzel S, Seigel A, Flickinger K, Hidalgo M, Bova GS, Iacobuzio-Donahue CA
Cancer Biol Ther. 2005
PubMed ID: 15846069
Transgenic mice that express Cre recombinase in hypertrophic chondrocytes.
Yang G, Cui F, Hou N, Cheng X, Zhang J, Wang Y, Jiang N, Gao X, Yang X
Genesis. 2005
PubMed ID: 15830383
Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase.
Dupont S, Zacchigna L, Cordenonsi M, Soligo S, Adorno M, Rugge M, Piccolo S
Cell. 2005
PubMed ID: 15820681
SMAD4 as a prognostic marker in colorectal cancer.
Alazzouzi H, Alhopuro P, Salovaara R, Sammalkorpi H, Järvinen H, Mecklin JP, Hemminki A, Schwartz S, Aaltonen LA, Arango D
Clin Cancer Res. 2005
PubMed ID: 15814640
Smad4 expression in gastric adenoma and adenocarcinoma: frequent loss of expression in diffuse type of gastric adenocarcinoma.
Kim JY, Park DY, Kim GH, Choi KU, Lee CH, Huh GY, Sol MY, Song GA, Jeon TY, Kim DH, Sim MS
Histol Histopathol. 2005
PubMed ID: 15736060
TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage.
Dubrovska A, Kanamoto T, Lomnytska M, Heldin CH, Volodko N, Souchelnytskyi S
Oncogene. 2005
PubMed ID: 15735739
Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4.
Chang CC, Lin DY, Fang HI, Chen RH, Shih HM
J Biol Chem. 2005
PubMed ID: 15637079
High-throughput mapping of a dynamic signaling network in mammalian cells.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL
Science. 2005
PubMed ID: 15761153
Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation.
Choi SJ, Moon JH, Ahn YW, Ahn JH, Kim DU, Han TH
Mol Cell Biochem. 2005
PubMed ID: 15881652
Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells.
Sonntag KC, Simantov R, Björklund L, Cooper O, Pruszak J, Kowalke F, Gilmartin J, Ding J, Hu YP, Shen MM, Isacson O
Mol Cell Neurosci. 2005
PubMed ID: 15737733
Specific interaction between Smad1 and CHIP: a surface plasmon resonance study.
Li RF, Zhang F, Lu YJ, Sui SF
Colloids Surf B Biointerfaces. 2005
PubMed ID: 15708501
Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling.
Wang H, Song K, Sponseller TL, Danielpour D
J Biol Chem. 2005
PubMed ID: 15561701
A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene.
Wilkinson DS, Ogden SK, Stratton SA, Piechan JL, Nguyen TT, Smulian GA, Barton MC
Mol Cell Biol. 2005
PubMed ID: 15657445
Smad4 deficiency in cervical carcinoma cells.
Baldus SE, Schwarz E, Lohrey C, Zapatka M, Landsberg S, Hahn SA, Schmidt D, Dienes HP, Schmiegel WH, Schwarte-Waldhoff I
Oncogene. 2005
PubMed ID: 15531914
Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta.
Jazag A, Ijichi H, Kanai F, Imamura T, Guleng B, Ohta M, Imamura J, Tanaka Y, Tateishi K, Ikenoue T, Kawakami T, Arakawa Y, Miyagishi M, Taira K, Kawabe T, Omata M
Oncogene. 2005
PubMed ID: 15592526
Multiple activities contribute to Pc2 E3 function.
Kagey MH, Melhuish TA, Powers SE, Wotton D
EMBO J. 2005
PubMed ID: 15592428
Ductal pancreatic cancer in humans and mice.
Tuveson DA, Hingorani SR
Cold Spring Harb Symp Quant Biol. 2005
PubMed ID: 16869739
Tagging genes with cassette-exchange sites.
Cobellis G, Nicolaus G, Iovino M, Romito A, Marra E, Barbarisi M, Sardiello M, Di Giorgio FP, Iovino N, Zollo M, Ballabio A, Cortese R
Nucleic Acids Res. 2005
PubMed ID: 15741177
Orofacial and gastrointestinal hyperplasia and neoplasia in smad4+/- and elf+/-/smad4+/- mutant mice.
Redman RS, Katuri V, Tang Y, Dillner A, Mishra B, Mishra L
J Oral Pathol Med. 2005
PubMed ID: 15610403
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
Bone morphogenetic proteins.
Chen D, Zhao M, Mundy GR
Growth Factors. 2004
PubMed ID: 15621726
Functional interaction between Smad, CREB binding protein, and p68 RNA helicase.
Warner DR, Bhattacherjee V, Yin X, Singh S, Mukhopadhyay P, Pisano MM, Greene RM
Biochem Biophys Res Commun. 2004
PubMed ID: 15464984
Baf60c is essential for function of BAF chromatin remodelling complexes in heart development.
Lickert H, Takeuchi JK, Von Both I, Walls JR, McAuliffe F, Adamson SL, Henkelman RM, Wrana JL, Rossant J, Bruneau BG
Nature. 2004
PubMed ID: 15525990
The murine gastrin promoter is synergistically activated by transforming growth factor-beta/Smad and Wnt signaling pathways.
Lei S, Dubeykovskiy A, Chakladar A, Wojtukiewicz L, Wang TC
J Biol Chem. 2004
PubMed ID: 15292219
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos.
Brugger SM, Merrill AE, Torres-Vazquez J, Wu N, Ting MC, Cho JY, Dobias SL, Yi SE, Lyons K, Bell JR, Arora K, Warrior R, Maxson R
Development. 2004
PubMed ID: 15459107
TGF-beta signaling is disrupted in endometrioid-type endometrial carcinomas.
Piestrzeniewicz-Ulanska D, Brys M, Semczuk A, Rechberger T, Jakowicki JA, Krajewska WM
Gynecol Oncol. 2004
PubMed ID: 15385128
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.
Loukopoulos P, Kanetaka K, Takamura M, Shibata T, Sakamoto M, Hirohashi S
Pancreas. 2004
PubMed ID: 15367885
Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators.
Subramanian SV, Polikandriotis JA, Kelm RJ, David JJ, Orosz CG, Strauch AR
Mol Biol Cell. 2004
PubMed ID: 15282343
Structural basis of heteromeric smad protein assembly in TGF-beta signaling.
Chacko BM, Qin BY, Tiwari A, Shi G, Lam S, Hayward LJ, De Caestecker M, Lin K
Mol Cell. 2004
PubMed ID: 15350224
TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population.
Oxburgh L, Chu GC, Michael SK, Robertson EJ
Development. 2004
PubMed ID: 15342483
Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2.
Liang M, Liang YY, Wrighton K, Ungermannova D, Wang XP, Brunicardi FC, Liu X, Feng XH, Lin X
Mol Cell Biol. 2004
PubMed ID: 15314162
Genomic analysis of mouse retinal development.
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
PLoS Biol. 2004
PubMed ID: 15226823
Analysis of Smad nucleocytoplasmic shuttling in living cells.
Nicolás FJ, De Bosscher K, Schmierer B, Hill CS
J Cell Sci. 2004
PubMed ID: 15280432
Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo.
Chu GC, Dunn NR, Anderson DC, Oxburgh L, Robertson EJ
Development. 2004
PubMed ID: 15215210
Smad expression in human atherosclerotic lesions: evidence for impaired TGF-beta/Smad signaling in smooth muscle cells of fibrofatty lesions.
Kalinina N, Agrotis A, Antropova Y, Ilyinskaya O, Smirnov V, Tararak E, Bobik A
Arterioscler Thromb Vasc Biol. 2004
PubMed ID: 15166010
Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling.
Sekiya T, Oda T, Matsuura K, Akiyama T
Biochem Biophys Res Commun. 2004
PubMed ID: 15240101
JNK regulates autocrine expression of TGF-beta1.
Ventura JJ, Kennedy NJ, Flavell RA, Davis RJ
Mol Cell. 2004
PubMed ID: 15260977
The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations.
Howe JR, Sayed MG, Ahmed AF, Ringold J, Larsen-Haidle J, Merg A, Mitros FA, Vaccaro CA, Petersen GM, Giardiello FM, Tinley ST, Aaltonen LA, Lynch HT
J Med Genet. 2004
PubMed ID: 15235019
Functional proteomics mapping of a human signaling pathway.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM
Genome Res. 2004
PubMed ID: 15231748
Expression of Smad2 and Smad4 in mouse uterus during the oestrous cycle and early pregnancy.
Liu G, Lin H, Zhang X, Li Q, Wang H, Qian D, Ni J, Zhu C
Placenta. 2004
PubMed ID: 15135236
Biologically different subgroups of invasive ductal carcinoma of the pancreas: Dpc4 status according to the ratio of intraductal carcinoma components.
Takahashi H, Oda T, Hasebe T, Aoyagi Y, Kinoshita T, Konishi M, Nakagohri T, Inoue K, Takahashi S, Kawahira H, Monden M, Ochiai A
Clin Cancer Res. 2004
PubMed ID: 15173084
Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF.
Dai C, Liu Y
J Am Soc Nephrol. 2004
PubMed ID: 15153551
Infrequent alteration of the DPC4 tumor suppressor gene in renal cell carcinoma.
Popović Hadzija M, Hrasćan R, Bosnar MH, Zeljko Z, Hadzija M, Cadez J, Pavelić K, Kapitanović S
Urol Res. 2004
PubMed ID: 15107966
Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1.
Liang M, Melchior F, Feng XH, Lin X
J Biol Chem. 2004
PubMed ID: 15028714
Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression.
Horvath LG, Henshall SM, Kench JG, Turner JJ, Golovsky D, Brenner PC, O'Neill GF, Kooner R, Stricker PD, Grygiel JJ, Sutherland RL
Prostate. 2004
PubMed ID: 15042598
Comparative analysis of cell adhesion molecules, cell cycle regulatory proteins, mismatch repair genes, cyclooxygenase-2, and DPC4 in carcinomas arising in inflammatory bowel disease and sporadic colon cancer.
Hill KA, Wang KL, Stryker SJ, Gupta R, Weinrach DM, Rao MS
Oncol Rep. 2004
PubMed ID: 15069531
Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1.
Bailey JS, Rave-Harel N, McGillivray SM, Coss D, Mellon PL
Mol Endocrinol. 2004
PubMed ID: 14764653
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
Seoane J, Le HV, Shen L, Anderson SA, Massagué J
Cell. 2004
PubMed ID: 15084259
Status of the DPC4 tumor suppressor gene in sporadic colon adenocarcinoma of Croatian patients: identification of a novel somatic mutation.
Popović Hadzija M, Radosevic S, Kovacević D, Lukac J, Hadzija M, Spaventi R, Pavelić K, Kapitanović S
Mutat Res. 2004
PubMed ID: 15063137
Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1.
Wan M, Tang Y, Tytler EM, Lu C, Jin B, Vickers SM, Yang L, Shi X, Cao X
J Biol Chem. 2004
PubMed ID: 14988407
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Prognostic significance of the expression of Smad4 and Smad7 in human gastric carcinomas.
Kim YH, Lee HS, Lee HJ, Hur K, Kim WH, Bang YJ, Kim SJ, Lee KU, Choe KJ, Yang HK
Ann Oncol. 2004
PubMed ID: 15033661
Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.
De Bosscher K, Hill CS, Nicolás FJ
Biochem J. 2004
PubMed ID: 14715079
Smad expression during kidney development.
Vrljicak P, Myburgh D, Ryan AK, van Rooijen MA, Mummery CL, Gupta IR
Am J Physiol Renal Physiol. 2004
PubMed ID: 14656760
Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.
Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S
Blood. 2004
PubMed ID: 14630787
A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4).
Gallione CJ, Repetto GM, Legius E, Rustgi AK, Schelley SL, Tejpar S, Mitchell G, Drouin E, Westermann CJ, Marchuk DA
Lancet. 2004
PubMed ID: 15031030
The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer.
Brown CO, Chi X, Garcia-Gras E, Shirai M, Feng XH, Schwartz RJ
J Biol Chem. 2004
PubMed ID: 14662776
Regulation of large-scale chromatin unfolding by Smad4.
Yan J, Fang Y, Ding L, Zhu J, Lu Q, Huang C, Yang X, Ye Q
Biochem Biophys Res Commun. 2004
PubMed ID: 14766211
Apoptosis incidence and protein expression of p53, TGF-beta receptor II, p27Kip1, and Smad4 in benign, premalignant, and malignant human prostate.
Zeng L, Rowland RG, Lele SM, Kyprianou N
Hum Pathol. 2004
PubMed ID: 15017584
Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors.
Iacobuzio-Donahue CA, Song J, Parmiagiani G, Yeo CJ, Hruban RH, Kern SE
Clin Cancer Res. 2004
PubMed ID: 15014009
A transforming growth factor beta-induced Smad3/Smad4 complex directly activates protein kinase A.
Zhang L, Duan CJ, Binkley C, Li G, Uhler MD, Logsdon CD, Simeone DM
Mol Cell Biol. 2004
PubMed ID: 14966294
Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski.
Takeda M, Mizuide M, Oka M, Watabe T, Inoue H, Suzuki H, Fujita T, Imamura T, Miyazono K, Miyazawa K
Mol Biol Cell. 2004
PubMed ID: 14699069
Identification of a gadd45beta 3' enhancer that mediates SMAD3- and SMAD4-dependent transcriptional induction by transforming growth factor beta.
Major MB, Jones DA
J Biol Chem. 2004
PubMed ID: 14630914
Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas.
Takeda H, Miyoshi H, Tamai Y, Oshima M, Taketo MM
Br J Cancer. 2004
PubMed ID: 14760387
Tumor-derived C-terminal mutations of Smad4 with decreased DNA binding activity and enhanced intramolecular interaction.
Kuang C, Chen Y
Oncogene. 2004
PubMed ID: 14647410
Expression of Smad2 and Smad4, transforming growth factor-beta signal transducers in rat endometrium during the estrous cycle, pre-, and peri-implantation.
Lin HY, Wang HM, Li QL, Liu DL, Zhang X, Liu GY, Qian D, Zhu C
Anim Reprod Sci. 2004
PubMed ID: 15036506
Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1.
Jonckheere N, Van Der Sluis M, Velghe A, Buisine MP, Sutmuller M, Ducourouble MP, Pigny P, Büller HA, Aubert JP, Einerhand AW, Van Seuningen I
Biochem J. 2004
PubMed ID: 14570593
A novel E1A-like inhibitor of differentiation (EID) family member, EID-2, suppresses transforming growth factor (TGF)-beta signaling by blocking TGF-beta-induced formation of Smad3-Smad4 complexes.
Lee HJ, Lee JK, Miyake S, Kim SJ
J Biol Chem. 2004
PubMed ID: 14612439
Loss of chromosome 18q and DPC4 (Smad4) mutations in appendiceal adenocarcinomas.
Maru D, Wu TT, Canada A, Houlihan PS, Hamilton SR, Rashid A
Oncogene. 2004
PubMed ID: 14647445
Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3).
Long J, Wang G, Matsuura I, He D, Liu F
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14691252
Loss of SMAD4 function in small intestinal adenocarcinomas: comparison of genetic and immunohistochemical findings.
Bläker H, Aulmann S, Helmchen B, Otto HF, Rieker RJ, Penzel R
Pathol Res Pract. 2004
PubMed ID: 15157044
LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density.
Mizuguchi T, Furuta I, Watanabe Y, Tsukamoto K, Tomita H, Tsujihata M, Ohta T, Kishino T, Matsumoto N, Minakami H, Niikawa N, Yoshiura K
J Hum Genet. 2004
PubMed ID: 14727154
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription.
Li L, Xin H, Xu X, Huang M, Zhang X, Chen Y, Zhang S, Fu XY, Chang Z
Mol Cell Biol. 2004
PubMed ID: 14701756
Identification of novel Smad binding proteins.
Warner DR, Roberts EA, Greene RM, Pisano MM
Biochem Biophys Res Commun. 2003
PubMed ID: 14651998
Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells.
Chiba S, Takeshita K, Imai Y, Kumano K, Kurokawa M, Masuda S, Shimizu K, Nakamura S, Ruddle FH, Hirai H
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14671321
TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development.
Nawshad A, Hay ED
J Cell Biol. 2003
PubMed ID: 14691138
DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.
Wu K, Yang Y, Wang C, Davoli MA, D'Amico M, Li A, Cveklova K, Kozmik Z, Lisanti MP, Russell RG, Cvekl A, Pestell RG
J Biol Chem. 2003
PubMed ID: 14525983
Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4.
Ohshima T, Shimotohno K
J Biol Chem. 2003
PubMed ID: 14514699
Smad4 and beta-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2.
Hussein SM, Duff EK, Sirard C
J Biol Chem. 2003
PubMed ID: 14551209
Loss of DPC4 expression and its correlation with clinicopathological parameters in pancreatic carcinoma.
Hua Z, Zhang YC, Hu XM, Jia ZG
World J Gastroenterol. 2003
PubMed ID: 14669329
p300 cooperates with Smad3/4 and Runx3 in TGFbeta1-induced IgA isotype expression.
Park SR, Lee EK, Kim BC, Kim PH
Eur J Immunol. 2003
PubMed ID: 14635047
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.
Xiao C, Shim JH, Klüppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S
Genes Dev. 2003
PubMed ID: 14633973
Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2.
Kim DW, Lassar AB
Mol Cell Biol. 2003
PubMed ID: 14612411
Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice.
Li W, Qiao W, Chen L, Xu X, Yang X, Li D, Li C, Brodie SG, Meguid MM, Hennighausen L, Deng CX
Development. 2003
PubMed ID: 14597578
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Intracellular dynamics of Smad-mediated TGFbeta signaling.
Greene RM, Nugent P, Mukhopadhyay P, Warner DR, Pisano MM
J Cell Physiol. 2003
PubMed ID: 14502566
Activation of TGF-beta-Smad signaling pathway following polyamine depletion in intestinal epithelial cells.
Liu L, Santora R, Rao JN, Guo X, Zou T, Zhang HM, Turner DJ, Wang JY
Am J Physiol Gastrointest Liver Physiol. 2003
PubMed ID: 12855402
Interaction of Smads with collagen types I, III, and V.
Ellis LR, Warner DR, Greene RM, Pisano MM
Biochem Biophys Res Commun. 2003
PubMed ID: 14559231
Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import.
Xu L, Alarcón C, Cöl S, Massagué J
J Biol Chem. 2003
PubMed ID: 12917407
Cerebellar deficits and hyperactivity in mice lacking Smad4.
Zhou YX, Zhao M, Li D, Shimazu K, Sakata K, Deng CX, Lu B
J Biol Chem. 2003
PubMed ID: 12896967
Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation.
Harada J, Kokura K, Kanei-Ishii C, Nomura T, Khan MM, Kim Y, Ishii S
J Biol Chem. 2003
PubMed ID: 12874272
Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4.
Kretschmer A, Moepert K, Dames S, Sternberger M, Kaufmann J, Klippel A
Oncogene. 2003
PubMed ID: 14555988
The expression of Smads in human endometrium and regulation and induction in endometrial epithelial and stromal cells by transforming growth factor-beta.
Luo X, Xu J, Chegini N
J Clin Endocrinol Metab. 2003
PubMed ID: 14557482
Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulation.
Roelen BA, Cohen OS, Raychowdhury MK, Chadee DN, Zhang Y, Kyriakis JM, Alessandrini AA, Lin HY
Am J Physiol Cell Physiol. 2003
PubMed ID: 12801888
Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3.
Imoto S, Sugiyama K, Muromoto R, Sato N, Yamamoto T, Matsuda T
J Biol Chem. 2003
PubMed ID: 12815042
The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein.
Ellsworth BS, Burns AT, Escudero KW, Duval DL, Nelson SE, Clay CM
Mol Cell Endocrinol. 2003
PubMed ID: 12943993
Direct interaction of Ski with either Smad3 or Smad4 is necessary and sufficient for Ski-mediated repression of transforming growth factor-beta signaling.
Ueki N, Hayman MJ
J Biol Chem. 2003
PubMed ID: 12857746
Differential ubiquitination defines the functional status of the tumor suppressor Smad4.
Morén A, Hellman U, Inada Y, Imamura T, Heldin CH, Moustakas A
J Biol Chem. 2003
PubMed ID: 12794086
Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT.
Long J, Matsuura I, He D, Wang G, Shuai K, Liu F
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904571
Developmental expression of BMP4/ALK3/SMAD5 signaling pathway in the mouse testis: a potential role of BMP4 in spermatogonia differentiation.
Pellegrini M, Grimaldi P, Rossi P, Geremia R, Dolci S
J Cell Sci. 2003
PubMed ID: 12857787
SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4.
Lin X, Liang M, Liang YY, Brunicardi FC, Feng XH
J Biol Chem. 2003
PubMed ID: 12813045
Expression and localization of the transforming growth factor-beta type I receptor and Smads in preneoplastic lesions during chemical hepatocarcinogenesis in rats.
Park DY, Lee CH, Sol MY, Suh KS, Yoon SY, Kim JW
J Korean Med Sci. 2003
PubMed ID: 12923327
Defective T-cell activation is associated with augmented transforming growth factor Beta sensitivity in mice with mutations in the Sno gene.
Pearson-White S, McDuffie M
Mol Cell Biol. 2003
PubMed ID: 12861029
Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer.
Maliekal TT, Antony ML, Nair A, Paulmurugan R, Karunagaran D
Oncogene. 2003
PubMed ID: 12894231
Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling.
Lee PS, Chang C, Liu D, Derynck R
J Biol Chem. 2003
PubMed ID: 12740389
The oncoprotein Ski acts as an antagonist of transforming growth factor-beta signaling by suppressing Smad2 phosphorylation.
Prunier C, Pessah M, Ferrand N, Seo SR, Howe P, Atfi A
J Biol Chem. 2003
PubMed ID: 12732634
Cell fate decisions within the mouse organizer are governed by graded Nodal signals.
Vincent SD, Dunn NR, Hayashi S, Norris DP, Robertson EJ
Genes Dev. 2003
PubMed ID: 12842913
Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation.
Kurisaki K, Kurisaki A, Valcourt U, Terentiev AA, Pardali K, Ten Dijke P, Heldin CH, Ericsson J, Moustakas A
Mol Cell Biol. 2003
PubMed ID: 12808092
Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation.
Haller D, Holt L, Kim SC, Schwabe RF, Sartor RB, Jobin C
J Biol Chem. 2003
PubMed ID: 12672795
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
Shi Y, Massagué J
Cell. 2003
PubMed ID: 12809600
Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest.
Nicolás FJ, Hill CS
Oncogene. 2003
PubMed ID: 12802277
Expression of Smad4 and Smad7 in human thyroid follicular carcinoma cell lines.
Cerutti JM, Ebina KN, Matsuo SE, Martins L, Maciel RM, Kimura ET
J Endocrinol Invest. 2003
PubMed ID: 12952364
Role of Smad4 on TGF-beta-induced extracellular matrix stimulation in mesangial cells.
Tsuchida K, Zhu Y, Siva S, Dunn SR, Sharma K
Kidney Int. 2003
PubMed ID: 12753287
Localization of activin and inhibin subunits, receptors and SMADs in the mouse mammary gland.
Jeruss JS, Santiago JY, Woodruff TK
Mol Cell Endocrinol. 2003
PubMed ID: 12782414
Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4.
Lin X, Liang M, Liang YY, Brunicardi FC, Melchior F, Feng XH
J Biol Chem. 2003
PubMed ID: 12621041
Regulation of MCP-1 gene transcription by Smads and HIV-1 Tat in human glial cells.
Abraham S, Sawaya BE, Safak M, Batuman O, Khalili K, Amini S
Virology. 2003
PubMed ID: 12758167
DPC-4 (Smad-4) and K-ras gene mutations in biliary tract epithelium in children with anomalous pancreaticobiliary ductal union.
Shimotake T, Aoi S, Tomiyama H, Iwai N
J Pediatr Surg. 2003
PubMed ID: 12720172
Smad4 as a transcription corepressor for estrogen receptor alpha.
Wu L, Wu Y, Gathings B, Wan M, Li X, Grizzle W, Liu Z, Lu C, Mao Z, Cao X
J Biol Chem. 2003
PubMed ID: 12576474
Distortion of autocrine transforming growth factor beta signal accelerates malignant potential by enhancing cell growth as well as PAI-1 and VEGF production in human hepatocellular carcinoma cells.
Sugano Y, Matsuzaki K, Tahashi Y, Furukawa F, Mori S, Yamagata H, Yoshida K, Matsushita M, Nishizawa M, Fujisawa J, Inoue K
Oncogene. 2003
PubMed ID: 12700666
Both Max and TFE3 cooperate with Smad proteins to bind the plasminogen activator inhibitor-1 promoter, but they have opposite effects on transcriptional activity.
Grinberg AV, Kerppola T
J Biol Chem. 2003
PubMed ID: 12551947
Identification of three novel Smad binding proteins involved in cell polarity.
Warner DR, Pisano MM, Roberts EA, Greene RM
FEBS Lett. 2003
PubMed ID: 12650946
Cellular response to hypoxia involves signaling via Smad proteins.
Zhang H, Akman HO, Smith EL, Zhao J, Murphy-Ullrich JE, Batuman OA
Blood. 2003
PubMed ID: 12411310
Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function.
Choy L, Derynck R
J Biol Chem. 2003
PubMed ID: 12524424
TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines.
Fink SP, Mikkola D, Willson JK, Markowitz S
Oncogene. 2003
PubMed ID: 12618756
Mechanism of a transcriptional cross talk between transforming growth factor-beta-regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4.
Chou WC, Prokova V, Shiraishi K, Valcourt U, Moustakas A, Hadzopoulou-Cladaras M, Zannis VI, Kardassis D
Mol Biol Cell. 2003
PubMed ID: 12631740
Differential expression, regulation, and induction of Smads, transforming growth factor-beta signal transduction pathway in leiomyoma, and myometrial smooth muscle cells and alteration by gonadotropin-releasing hormone analog.
Xu J, Luo X, Chegini N
J Clin Endocrinol Metab. 2003
PubMed ID: 12629129
A major locus on mouse chromosome 18 controls XX sex reversal in Odd Sex (Ods) mice.
Qin Y, Poirier C, Truong C, Schumacher A, Agoulnik AI, Bishop CE
Hum Mol Genet. 2003
PubMed ID: 12588798
Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene.
Hohenstein P, Molenaar L, Elsinga J, Morreau H, van der Klift H, Struijk A, Jagmohan-Changur S, Smits R, van Kranen H, van Ommen GJ, Cornelisse C, Devilee P, Fodde R
Genes Chromosomes Cancer. 2003
PubMed ID: 12557227
Expression of Smad4 in the FaDu cell line partially restores TGF-beta growth inhibition but is not sufficient to regulate fibronectin expression or suppress tumorigenicity.
Hummer BT, Bartlett C, Henry E, Weissman BE
J Cell Physiol. 2003
PubMed ID: 12548549
Infrequent mutation of the tumour-suppressor gene Smad4 in early-stage colorectal cancer.
Mamot C, Mild G, Reuter J, Laffer U, Metzger U, Terracciano L, Boulay JL, Herrmann R, Rochlitz C
Br J Cancer. 2003
PubMed ID: 12569386
Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus.
Silverman KA, Koratkar RA, Siracusa LD, Buchberg AM
Mamm Genome. 2003
PubMed ID: 12584607
Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice.
Tang Y, Katuri V, Dillner A, Mishra B, Deng CX, Mishra L
Science. 2003
PubMed ID: 12543979
A central role for the JNK pathway in mediating the antagonistic activity of pro-inflammatory cytokines against transforming growth factor-beta-driven SMAD3/4-specific gene expression.
Verrecchia F, Tacheau C, Wagner EF, Mauviel A
J Biol Chem. 2003
PubMed ID: 12426318
TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins.
Evans RA, Tian YC, Steadman R, Phillips AO
Exp Cell Res. 2003
PubMed ID: 12531695
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Stoichiometry of active smad-transcription factor complexes on DNA.
Inman GJ, Hill CS
J Biol Chem. 2002
PubMed ID: 12374795
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
MdmX inhibits Smad transactivation.
Kadakia M, Brown TL, McGorry MM, Berberich SJ
Oncogene. 2002
PubMed ID: 12483531
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells.
Vivian JL, Chen Y, Yee D, Schneider E, Magnuson T
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12432092
Regulation of Hex gene expression by a Smads-dependent signaling pathway.
Zhang W, Yatskievych TA, Cao X, Antin PB
J Biol Chem. 2002
PubMed ID: 12270938
Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation.
Hager-Theodorides AL, Outram SV, Shah DK, Sacedon R, Shrimpton RE, Vicente A, Varas A, Crompton T
J Immunol. 2002
PubMed ID: 12421925
Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4.
Kang HY, Huang KE, Chang SY, Ma WL, Lin WJ, Chang C
J Biol Chem. 2002
PubMed ID: 12226080
The relationship between loss expression of DPC4/Smad4 gene and carcinogenesis of pancreatobiliary carcinoma.
Tang ZH, Zou SQ, Hao YH, Wang BJ, Yang XP, Chen QQ, Qiu FZ
Hepatobiliary Pancreat Dis Int. 2002
PubMed ID: 14607700
Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells.
Peng B, Fleming JB, Breslin T, Grau AM, Fojioka S, Abbruzzese JL, Evans DB, Ayers D, Wathen K, Wu T, Robertson KD, Chiao PJ
Clin Cancer Res. 2002
PubMed ID: 12429655
Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling.
Wu JW, Krawitz AR, Chai J, Li W, Zhang F, Luo K, Shi Y
Cell. 2002
PubMed ID: 12419246
Germline SMAD4 or BMPR1A mutations and phenotype of juvenile polyposis.
Sayed MG, Ahmed AF, Ringold JR, Anderson ME, Bair JL, Mitros FA, Lynch HT, Tinley ST, Petersen GM, Giardiello FM, Vogelstein B, Howe JR
Ann Surg Oncol. 2002
PubMed ID: 12417513
Restoration of transforming growth factor Beta signaling by functional expression of smad4 induces anoikis.
Ramachandra M, Atencio I, Rahman A, Vaillancourt M, Zou A, Avanzini J, Wills K, Bookstein R, Shabram P
Cancer Res. 2002
PubMed ID: 12414627
Smad4 overexpression causes germ cell ablation and leydig cell hyperplasia in transgenic mice.
Narula A, Kilen S, Ma E, Kroeger J, Goldberg E, Woodruff TK
Am J Pathol. 2002
PubMed ID: 12414519
Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.
Jiao K, Zhou Y, Hogan BL
Mol Cell Biol. 2002
PubMed ID: 12370310
Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors.
Li C, Zhu NL, Tan RC, Ballard PL, Derynck R, Minoo P
J Biol Chem. 2002
PubMed ID: 12161428
Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding element.
Lee DK, Kim BC, Brady JN, Jeang KT, Kim SJ
J Biol Chem. 2002
PubMed ID: 12097320
Decreased Smad4 expression in the transforming growth factor-beta signaling pathway during progression of esophageal squamous cell carcinoma.
Fukuchi M, Masuda N, Miyazaki T, Nakajima M, Osawa H, Kato H, Kuwano H
Cancer. 2002
PubMed ID: 12209716
A component of the ARC/Mediator complex required for TGF beta/Nodal signalling.
Kato Y, Habas R, Katsuyama Y, Näär AM, He X
Nature. 2002
PubMed ID: 12167862
Interaction between TGFbeta signaling proteins and C/EBP controls basal and Tat-mediated transcription of HIV-1 LTR in astrocytes.
Coyle-Rink J, Sweet T, Abraham S, Sawaya B, Batuman O, Khalili K, Amini S
Virology. 2002
PubMed ID: 12202226
Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity.
Inman GJ, Nicolás FJ, Hill CS
Mol Cell. 2002
PubMed ID: 12191474
Transforming growth factor-beta-induced transcription of the Alzheimer beta-amyloid precursor protein gene involves interaction between the CTCF-complex and Smads.
Burton T, Liang B, Dibrov A, Amara F
Biochem Biophys Res Commun. 2002
PubMed ID: 12099698
E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression.
Chen CR, Kang Y, Siegel PM, Massagué J
Cell. 2002
PubMed ID: 12150994
Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes.
Cullingworth J, Hooper ML, Harrison DJ, Mason JO, Sirard C, Patek CE, Clarke AR
Oncogene. 2002
PubMed ID: 12096346
Juvenile polyposis: massive gastric polyposis is more common in MADH4 mutation carriers than in BMPR1A mutation carriers.
Friedl W, Uhlhaas S, Schulmann K, Stolte M, Loff S, Back W, Mangold E, Stern M, Knaebel HP, Sutter C, Weber RG, Pistorius S, Burger B, Propping P
Hum Genet. 2002
PubMed ID: 12136244
Novel de novo mutation of MADH4/SMAD4 in a patient with juvenile polyposis.
Burger B, Uhlhaas S, Mangold E, Propping P, Friedl W, Jenne D, Dockter G, Back W
Am J Med Genet. 2002
PubMed ID: 12116240
Frequent loss of SMAD4/DPC4 protein in colorectal cancers.
Salovaara R, Roth S, Loukola A, Launonen V, Sistonen P, Avizienyte E, Kristo P, Järvinen H, Souchelnytskyi S, Sarlomo-Rikala M, Aaltonen LA
Gut. 2002
PubMed ID: 12077092
Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma.
Biankin AV, Biankin SA, Kench JG, Morey AL, Lee CS, Head DR, Eckstein RP, Hugh TB, Henshall SM, Sutherland RL
Gut. 2002
PubMed ID: 12010891
An EVH1/WH1 domain as a key actor in TGFbeta signalling.
Callebaut I
FEBS Lett. 2002
PubMed ID: 12023040
Interaction between the transforming growth factor-beta type II receptor/Smad pathway and beta-catenin during transforming growth factor-beta1-mediated adherens junction disassembly.
Tian YC, Phillips AO
Am J Pathol. 2002
PubMed ID: 12000714
Common deletion of SMAD4 in juvenile polyposis is a mutational hotspot.
Howe JR, Shellnut J, Wagner B, Ringold JC, Sayed MG, Ahmed AF, Lynch PM, Amos CI, Sistonen P, Aaltonen LA
Am J Hum Genet. 2002
PubMed ID: 11920286
[Location studies of Smad4 protein in the rat testis during postnatal development]
Zhang YQ, Hu J, Liu XP, Wang RA, Xu RJ
Shi Yan Sheng Wu Xue Bao. 2002
PubMed ID: 15344310
Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney.
Oxburgh L, Robertson EJ
Mech Dev. 2002
PubMed ID: 11850197
SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling.
Bai RY, Koester C, Ouyang T, Hahn SA, Hammerschmidt M, Peschel C, Duyster J
Nat Cell Biol. 2002
PubMed ID: 11836524
Generation of Smad4/Dpc4 conditional knockout mice.
Yang X, Li C, Herrera PL, Deng CX
Genesis. 2002
PubMed ID: 11857783
Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation.
Wan M, Cao X, Wu Y, Bai S, Wu L, Shi X, Wang N, Cao X
EMBO Rep. 2002
PubMed ID: 11818334
Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene.
López-Rovira T, Chalaux E, Massagué J, Rosa JL, Ventura F
J Biol Chem. 2002
PubMed ID: 11700304
Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps.
Seno H, Oshima M, Ishikawa TO, Oshima H, Takaku K, Chiba T, Narumiya S, Taketo MM
Cancer Res. 2002
PubMed ID: 11809702
Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study.
Xie W, Mertens JC, Reiss DJ, Rimm DL, Camp RL, Haffty BG, Reiss M
Cancer Res. 2002
PubMed ID: 11809701
Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes.
Park GT, Morasso MI
Nucleic Acids Res. 2002
PubMed ID: 11788714
A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-beta1 (TGF-beta1) and its signaling pathway.
Watanabe Y, Kinoshita A, Yamada T, Ohta T, Kishino T, Matsumoto N, Ishikawa M, Niikawa N, Yoshiura K
J Hum Genet. 2002
PubMed ID: 12202987
[Detection of the expression of Smad4, transforming growth factor beta(1) and beta receptor II proteins in paraffin-embedded human pancreatic cancer tissues]
Gu L, Chen J, Liu T, Li L, Lu Z, Luo Y
Zhonghua Bing Li Xue Za Zhi. 2001
PubMed ID: 11866987
LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1.
Smith DP, Rayter SI, Niederlander C, Spicer J, Jones CM, Ashworth A
Hum Mol Genet. 2001
PubMed ID: 11741830
Cross-talk between transforming growth factor-beta and estrogen receptor signaling through Smad3.
Matsuda T, Yamamoto T, Muraguchi A, Saatcioglu F
J Biol Chem. 2001
PubMed ID: 11555647
Identification of a critical Sp1 site within the endoglin promoter and its involvement in the transforming growth factor-beta stimulation.
Botella LM, Sánchez-Elsner T, Rius C, Corbí A, Bernabéu C
J Biol Chem. 2001
PubMed ID: 11432852
FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins.
Bartholin L, Maguer-Satta V, Hayette S, Martel S, Gadoux M, Bertrand S, Corbo L, Lamadon C, Morera AM, Magaud JP, Rimokh R
Oncogene. 2001
PubMed ID: 11571638
Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor-beta signaling.
Rodriguez C, Huang LJ, Son JK, McKee A, Xiao Z, Lodish HF
J Biol Chem. 2001
PubMed ID: 11387330
[Alterations in DPC4 gene in pancreatic cancers]
Gu L, Chen J, Cui Q
Zhonghua Zhong Liu Za Zhi. 2001
PubMed ID: 11783110
Formation of a stable heterodimer between Smad2 and Smad4.
Wu JW, Fairman R, Penry J, Shi Y
J Biol Chem. 2001
PubMed ID: 11274206
Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone.
Wurthner JU, Frank DB, Felici A, Green HM, Cao Z, Schneider MD, McNally JG, Lechleider RJ, Roberts AB
J Biol Chem. 2001
PubMed ID: 11278302
Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription.
Leong GM, Subramaniam N, Figueroa J, Flanagan JL, Hayman MJ, Eisman JA, Kouzmenko AP
J Biol Chem. 2001
PubMed ID: 11278756
Transforming growth factor-beta pathway in human renal cell carcinoma and surrounding normal-appearing renal parenchyma.
Cardillo MR, Lazzereschi D, Gandini O, Di Silverio F, Colletta G
Anal Quant Cytol Histol. 2001
PubMed ID: 11332076
Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
Blood. 2001
PubMed ID: 11264182
Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells.
Poncelet AC, Schnaper HW
J Biol Chem. 2001
PubMed ID: 11114293
Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor.
Razani B, Zhang XL, Bitzer M, von Gersdorff G, Böttinger EP, Lisanti MP
J Biol Chem. 2001
PubMed ID: 11102446
[Deletion mapping of chromosome 18q and Smad proteins expression analysis in urinary bladder carcinomas].
Fan Z, Zhang J, Bai J
Zhonghua Zhong Liu Za Zhi. 2001
PubMed ID: 11783019
Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus.
Yanaihara N, Kohno T, Takakura S, Takei K, Otsuka A, Sunaga N, Takahashi M, Yamazaki M, Tashiro H, Fukuzumi Y, Fujimori Y, Hagiwara K, Tanaka T, Yokota J
Genomics. 2001
PubMed ID: 11401430
Developmentally regulated expression of Smad3, Smad4, Smad6, and Smad7 involved in TGF-beta signaling.
Luukko K, Ylikorkala A, Mäkelä TP
Mech Dev. 2001
PubMed ID: 11231077
The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization.
Chacko BM, Qin B, Correia JJ, Lam SS, de Caestecker MP, Lin K
Nat Struct Biol. 2001
PubMed ID: 11224571
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Immunohistochemical expression of Smads 1-6 in the 15-day gestation mouse embryo: signaling by BMPs and TGF-betas.
Flanders KC, Kim ES, Roberts AB
Dev Dyn. 2001
PubMed ID: 11169847
Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins.
Quinn ZA, Yang CC, Wrana JL, McDermott JC
Nucleic Acids Res. 2001
PubMed ID: 11160896
Hoxa-9 represses transforming growth factor-beta-induced osteopontin gene transcription.
Shi X, Bai S, Li L, Cao X
J Biol Chem. 2001
PubMed ID: 11042172
SMAD proteins transactivate the human ApoCIII promoter by interacting physically and functionally with hepatocyte nuclear factor 4.
Kardassis D, Pardali K, Zannis VI
J Biol Chem. 2000
PubMed ID: 10995777
Negative regulation of BMP/Smad signaling by Tob in osteoblasts.
Yoshida Y, Tanaka S, Umemori H, Minowa O, Usui M, Ikematsu N, Hosoda E, Imamura T, Kuno J, Yamashita T, Miyazono K, Noda M, Noda T, Yamamoto T
Cell. 2000
PubMed ID: 11163184
Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells.
Wang W, Mariani FV, Harland RM, Luo K
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11121043
Fine mapping and characterization of candidate lung tumor resistance genes for the Par2 locus on mouse chromosome 18.
Zhang Z, Lin L, Liu G, Wang M, Hill J, Wang Y, You M, Devereux TR
Exp Lung Res. 2000
PubMed ID: 11195460
Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis.
Dünker N, Krieglstein K
Eur J Biochem. 2000
PubMed ID: 11106407
Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis.
Yamamura Y, Hua X, Bergelson S, Lodish HF
J Biol Chem. 2000
PubMed ID: 10942775
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II.
Wicks SJ, Lui S, Abdel-Wahab N, Mason RM, Chantry A
Mol Cell Biol. 2000
PubMed ID: 11027280
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.
Pardali K, Kurisaki A, Morén A, ten Dijke P, Kardassis D, Moustakas A
J Biol Chem. 2000
PubMed ID: 10878024
Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4.
Morén A, Itoh S, Moustakas A, Dijke P, Heldin CH
Oncogene. 2000
PubMed ID: 10980615
Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice.
Taketo MM, Takaku K
Hum Cell. 2000
PubMed ID: 11197776
Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat.
Szpirer C, Van Vooren P, Rivière M, Scohy S, Collau G, Szpirer J
Mamm Genome. 2000
PubMed ID: 10967130
Importin beta mediates nuclear translocation of Smad 3.
Xiao Z, Liu X, Lodish HF
J Biol Chem. 2000
PubMed ID: 10846168
Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal.
Watanabe M, Masuyama N, Fukuda M, Nishida E
EMBO Rep. 2000
PubMed ID: 11265759
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Modulation of endogenous Smad expression in normal skin fibroblasts by transforming growth factor-beta.
Mori Y, Chen SJ, Varga J
Exp Cell Res. 2000
PubMed ID: 10896788
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways.
Labbé E, Letamendia A, Attisano L
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10890911
A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction.
Kim RH, Wang D, Tsang M, Martin J, Huff C, de Caestecker MP, Parks WT, Meng X, Lechleider RJ, Wang T, Roberts AB
Genes Dev. 2000
PubMed ID: 10887155
Functional mapping of the MH1 DNA-binding domain of DPC4/SMAD4.
Jones JB, Kern SE
Nucleic Acids Res. 2000
PubMed ID: 10871368
Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter.
Denissova NG, Pouponnot C, Long J, He D, Liu F
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10823886
Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway.
Xu J, Attisano L
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10781087
Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.
Xu X, Brodie SG, Yang X, Im YH, Parks WT, Chen L, Zhou YX, Weinstein M, Kim SJ, Deng CX
Oncogene. 2000
PubMed ID: 10773876
Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal.
Roth S, Johansson M, Loukola A, Peltomäki P, Järvinen H, Mecklin JP, Aaltonen LA
J Med Genet. 2000
PubMed ID: 10819637
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
Gastro-intestinal tumorigenesis in Smad4 mutant mice.
Taketo MM, Takaku K
Cytokine Growth Factor Rev. 2000
PubMed ID: 10708962
Functions of mammalian Smad genes as revealed by targeted gene disruption in mice.
Weinstein M, Yang X, Deng C
Cytokine Growth Factor Rev. 2000
PubMed ID: 10708952
TGF-beta signaling by Smad proteins.
Miyazono K
Cytokine Growth Factor Rev. 2000
PubMed ID: 10708949
The Smad pathway.
Wrana JL, Attisano L
Cytokine Growth Factor Rev. 2000
PubMed ID: 10708948
A novel SMAD4 gene mutation in seminoma germ cell tumors.
Bouras M, Tabone E, Bertholon J, Sommer P, Bouvier R, Droz JP, Benahmed M
Cancer Res. 2000
PubMed ID: 10706106
OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways.
Hata A, Seoane J, Lagna G, Montalvo E, Hemmati-Brivanlou A, Massagué J
Cell. 2000
PubMed ID: 10660046
The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain.
de Caestecker MP, Yahata T, Wang D, Parks WT, Huang S, Hill CS, Shioda T, Roberts AB, Lechleider RJ
J Biol Chem. 2000
PubMed ID: 10636916
Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.
Sirard C, Kim S, Mirtsos C, Tadich P, Hoodless PA, Itié A, Maxson R, Wrana JL, Mak TW
J Biol Chem. 2000
PubMed ID: 10636910
Crystal structure of a transcriptionally active Smad4 fragment.
Qin B, Lam SS, Lin K
Structure. 1999
PubMed ID: 10647180
Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice.
Takaku K, Miyoshi H, Matsunaga A, Oshima M, Sasaki N, Taketo MM
Cancer Res. 1999
PubMed ID: 10626800
c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads.
Akiyoshi S, Inoue H, Hanai J, Kusanagi K, Nemoto N, Miyazono K, Kawabata M
J Biol Chem. 1999
PubMed ID: 10575014
Specificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteins.
Hua X, Miller ZA, Wu G, Shi Y, Lodish HF
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10557285
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter.
Hanai J, Chen LF, Kanno T, Ohtani-Fujita N, Kim WY, Guo WH, Imamura T, Ishidou Y, Fukuchi M, Shi MJ, Stavnezer J, Kawabata M, Miyazono K, Ito Y
J Biol Chem. 1999
PubMed ID: 10531362
Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein.
Stroschein SL, Wang W, Zhou S, Zhou Q, Luo K
Science. 1999
PubMed ID: 10531062
Going mad with Smads.
Zhou S, Kinzler KW, Vogelstein B
N Engl J Med. 1999
PubMed ID: 10511616
cDNA cloning and chromosomal mapping of rat Smad2 and Smad4 and their expression in cultured rat articular chondrocytes.
Osaki M, Tsukazaki T, Ono N, Yonekura A, Hirota Y, Miyazaki Y, Shindo H, Sonta S, Yamashita S
Endocr J. 1999
PubMed ID: 10670756
Smad8B, a Smad8 splice variant lacking the SSXS site that inhibits Smad8-mediated signalling.
Nishita M, Ueno N, Shibuya H
Genes Cells. 1999
PubMed ID: 10583507
Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling.
Sun Y, Liu X, Eaton EN, Lane WS, Lodish HF, Weinberg RA
Mol Cell. 1999
PubMed ID: 10549282
Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.
Verschueren K, Huylebroeck D
Cytokine Growth Factor Rev. 1999
PubMed ID: 10647776
Frequent 4-bp deletion in exon 9 of the SMAD4/MADH4 gene in familial juvenile polyposis patients.
Friedl W, Kruse R, Uhlhaas S, Stolte M, Schartmann B, Keller KM, Jungck M, Stern M, Loff S, Back W, Propping P, Jenne DE
Genes Chromosomes Cancer. 1999
PubMed ID: 10398437
Interaction of Smad complexes with tripartite DNA-binding sites.
Johnson K, Kirkpatrick H, Comer A, Hoffmann FM, Laughon A
J Biol Chem. 1999
PubMed ID: 10400705
SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes.
Verschueren K, Remacle JE, Collart C, Kraft H, Baker BS, Tylzanowski P, Nelles L, Wuytens G, Su MT, Bodmer R, Smith JC, Huylebroeck D
J Biol Chem. 1999
PubMed ID: 10400677
Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling.
Shi X, Yang X, Chen D, Chang Z, Cao X
J Biol Chem. 1999
PubMed ID: 10224145
Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals.
Christian JL, Nakayama T
Bioessays. 1999
PubMed ID: 10376010
Involvement of mutations in the DPC4 promoter in endometrial carcinoma development.
Zhou Y, Kato H, Shan D, Minami R, Kitazawa S, Matsuda T, Arima T, Barrett JC, Wake N
Mol Carcinog. 1999
PubMed ID: 10331746
Smads bind directly to the Jun family of AP-1 transcription factors.
Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10220381
A Smad transcriptional corepressor.
Wotton D, Lo RS, Lee S, Massagué J
Cell. 1999
PubMed ID: 10199400
ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling.
Sano Y, Harada J, Tashiro S, Gotoh-Mandeville R, Maekawa T, Ishii S
J Biol Chem. 1999
PubMed ID: 10085140
MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells.
Brown JD, DiChiara MR, Anderson KR, Gimbrone MA, Topper JN
J Biol Chem. 1999
PubMed ID: 10085121
Allelic imbalance in chromosome band 18q21 and SMAD4 mutations in ovarian cancers.
Takakura S, Okamoto A, Saito M, Yasuhara T, Shinozaki H, Isonishi S, Yoshimura T, Ohtake Y, Ochiai K, Tanaka T
Genes Chromosomes Cancer. 1999
PubMed ID: 10451707
Ectopic expression of the transforming growth factor beta type II receptor disrupts mesoderm organisation during mouse gastrulation.
Zwijsen A, Goumans MJ, Lawson KA, Van Rooijen MA, Mummery CL
Dev Dyn. 1999
PubMed ID: 10030593
Roles of pathway-specific and inhibitory Smads in activin receptor signaling.
Lebrun JJ, Takabe K, Chen Y, Vale W
Mol Endocrinol. 1999
PubMed ID: 9892009
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Genetic events and the role of TGF beta in epithelial tumour progression.
Akhurst RJ, Balmain A
J Pathol. 1999
PubMed ID: 10341708
TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein.
Shen X, Hu PP, Liberati NT, Datto MB, Frederick JP, Wang XF
Mol Biol Cell. 1998
PubMed ID: 9843571
Carboxy-terminally truncated Gli3 proteins associate with Smads.
Liu F, Massagué J, Ruiz i Altaba A
Nat Genet. 1998
PubMed ID: 9843199
A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis.
Weisberg E, Winnier GE, Chen X, Farnsworth CL, Hogan BL, Whitman M
Mech Dev. 1998
PubMed ID: 10349617
Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Ko MS, Threat TA, Wang X, Horton JH, Cui Y, Wang X, Pryor E, Paris J, Wells-Smith J, Kitchen JR, Rowe LB, Eppig J, Satoh T, Brant L, Fujiwara H, Yotsumoto S, Nakashima H
Hum Mol Genet. 1998
PubMed ID: 9811942
Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.
Houlston R, Bevan S, Williams A, Young J, Dunlop M, Rozen P, Eng C, Markie D, Woodford-Richens K, Rodriguez-Bigas MA, Leggett B, Neale K, Phillips R, Sheridan E, Hodgson S, Iwama T, Eccles D, Bodmer W, Tomlinson I
Hum Mol Genet. 1998
PubMed ID: 9811934
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.
Shi Y, Wang YF, Jayaraman L, Yang H, Massagué J, Pavletich NP
Cell. 1998
PubMed ID: 9741623
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.
Zhang Y, Feng XH, Derynck R
Nature. 1998
PubMed ID: 9732876
Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator.
Shioda T, Lechleider RJ, Dunwoodie SL, Li H, Yahata T, de Caestecker MP, Fenner MH, Roberts AB, Isselbacher KJ
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9707553
TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300.
Janknecht R, Wells NJ, Hunter T
Genes Dev. 1998
PubMed ID: 9679056
Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors.
Kawabata M, Inoue H, Hanyu A, Imamura T, Miyazono K
EMBO J. 1998
PubMed ID: 9670020
Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2.
Labbé E, Silvestri C, Hoodless PA, Wrana JL, Attisano L
Mol Cell. 1998
PubMed ID: 9702197
Mutations in the SMAD4/DPC4 gene in juvenile polyposis.
Howe JR, Roth S, Ringold JC, Summers RW, Järvinen HJ, Sistonen P, Tomlinson IP, Houlston RS, Bevan S, Mitros FA, Stone EM, Aaltonen LA
Science. 1998
PubMed ID: 9582123
The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice.
Yang X, Li C, Xu X, Deng C
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9520423
Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo.
Waldrip WR, Bikoff EK, Hoodless PA, Wrana JL, Robertson EJ
Cell. 1998
PubMed ID: 9529255
Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes.
Takaku K, Oshima M, Miyoshi H, Matsui M, Seldin MF, Taketo MM
Cell. 1998
PubMed ID: 9506519
Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.
Zhou S, Buckhaults P, Zawel L, Bunz F, Riggins G, Dai JL, Kern SE, Kinzler KW, Vogelstein B
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9482899
Human Smad3 and Smad4 are sequence-specific transcription activators.
Zawel L, Dai JL, Buckhaults P, Zhou S, Kinzler KW, Vogelstein B, Kern SE
Mol Cell. 1998
PubMed ID: 9660945
TGF-beta signal transduction.
Massagué J
Annu Rev Biochem. 1998
PubMed ID: 9759503
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo.
Sirard C, de la Pompa JL, Elia A, Itie A, Mirtsos C, Cheung A, Hahn S, Wakeham A, Schwartz L, Kern SE, Rossant J, Mak TW
Genes Dev. 1998
PubMed ID: 9420335
TGF-beta signalling from cell membrane to nucleus through SMAD proteins.
Heldin CH, Miyazono K, ten Dijke P
Nature. 1997
PubMed ID: 9393997
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.
Liu F, Pouponnot C, Massagué J
Genes Dev. 1997
PubMed ID: 9389648
Smad4 and FAST-1 in the assembly of activin-responsive factor.
Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M
Nature. 1997
PubMed ID: 9288972
Smad4 (homolog of human DPC4) and Smad2 (homolog of human JV18-1): candidates for murine lung tumor resistance and suppressor genes.
Devereux TR, Anna CH, Patel AC, White CM, Festing MF, You M
Carcinogenesis. 1997
PubMed ID: 9328171
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.
Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P
EMBO J. 1997
PubMed ID: 9311995
Molecular pathology in basal cell cancer with p53 as a genetic marker.
Pontén F, Berg C, Ahmadian A, Ren ZP, Nistér M, Lundeberg J, Uhlén M, Pontén J
Oncogene. 1997
PubMed ID: 9285560
Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium.
Topper JN, Cai J, Qiu Y, Anderson KR, Xu YY, Deeds JD, Feeley R, Gimeno CJ, Woolf EA, Tayber O, Mays GG, Sampson BA, Schoen FJ, Gimbrone MA, Falb D
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9256479
A structural basis for mutational inactivation of the tumour suppressor Smad4.
Shi Y, Hata A, Lo RS, Massagué J, Pavletich NP
Nature. 1997
PubMed ID: 9214508
Sequence and chromosomal mapping of the mouse homolog (Madh4) of the human DPC4/MADH4 gene.
Anna CH, Devereux TR
Mamm Genome. 1997
PubMed ID: 9166592
Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4.
Wu RY, Zhang Y, Feng XH, Derynck R
Mol Cell Biol. 1997
PubMed ID: 9111321
Genomic sequencing of DPC4 in the analysis of familial pancreatic carcinoma.
Moskaluk CA, Hruban RH, Schutte M, Lietman AS, Smyrk T, Fusaro L, Fusaro R, Lynch J, Yeo CJ, Jackson CE, Lynch HT, Kern SE
Diagn Mol Pathol. 1997
PubMed ID: 9098646
Nomenclature: vertebrate mediators of TGFbeta family signals.
Derynck R, Gelbart WM, Harland RM, Heldin CH, Kern SE, Massagué J, Melton DA, Mlodzik M, Padgett RW, Roberts AB, Smith J, Thomsen GH, Vogelstein B, Wang XF
Cell. 1996
PubMed ID: 8861901
Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
Zhang Y, Feng X, We R, Derynck R
Nature. 1996
PubMed ID: 8774881
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
DPC4 gene in various tumor types.
Schutte M, Hruban RH, Hedrick L, Cho KR, Nadasdy GM, Weinstein CL, Bova GS, Isaacs WB, Cairns P, Nawroz H, Sidransky D, Casero RA, Meltzer PS, Hahn SA, Kern SE
Cancer Res. 1996
PubMed ID: 8653691
Homozygous deletion map at 18q21.1 in pancreatic cancer.
Hahn SA, Hoque AT, Moskaluk CA, da Costa LT, Schutte M, Rozenblum E, Seymour AB, Weinstein CL, Yeo CJ, Hruban RH, Kern SE
Cancer Res. 1996
PubMed ID: 8564959
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.
Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE
Science. 1996
PubMed ID: 8553070
E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.
Beijersbergen RL, Kerkhoven RM, Zhu L, Carlée L, Voorhoeve PM, Bernards R
Genes Dev. 1994
PubMed ID: 7958925
E2F-4, a new member of the E2F transcription factor family, interacts with p107.
Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM
Genes Dev. 1994
PubMed ID: 7958924
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Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	4089	17128	50554
EnsEMBL Gene(s)	ENSG00000141646	ENSMUSG00000024515	ENSRNOG00000015634
Unigene	Hs.75862	Mm.100399	Rn.9774
Homologene	SMAD4	Smad4	Smad4
OMIM	600993	N/A	N/A
GeneCards	SMAD4	N/A	N/A
Beta Cell Genomics	DT.105413 DT.317208	DT.101402140 DT.101721177 DT.534367	N/A
Reactome	Q13485	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	4089	17128	50554

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Interactor	Interactor	Sources	Classification	Pubmed IDs
SMAD4	OCLN	HPRD, BioGRID	empirical	15761153
SMAD4	TRAP1	HPRD	empirical	11278302
SMAD4	ARFRP1	HPRD, BioGRID	empirical	15761153
SMAD4	TOB1	HPRD, BioGRID	empirical	11163184
SMAD4	CNKSR1	HPRD, MINT	empirical	15231748
SMAD4	FSTL3	HPRD	empirical	11571638
SMAD4	STUB1	HPRD, BioGRID	empirical	15708501 14701756
SMAD4	HMG20A	HPRD, MINT	empirical	15231748
SMAD4	PIAS3	HPRD, BioGRID	empirical	14691252
SMAD4	GPNMB	HPRD, MINT	empirical	15231748
SMAD4	CEBPA	BioGRID	empirical	12524424
SMAD4	CEBPB	HPRD, MINT, IntAct	empirical	12524424 12202226 16959612
SMAD4	CEBPD	BioGRID	empirical	12524424
SMAD4	CTCF	HPRD	empirical	12099698
SMAD4	PLK4	HPRD, MINT, BioGRID	empirical	15761153
SMAD4	NEK6	HPRD, BioGRID	empirical	15761153
SMAD4	COPS5	HPRD, IntAct, BioGRID	empirical	11818334 14993265
SMAD4	CHEK1	HPRD, MINT, BioGRID	empirical	15761153
SMAD4	STK11IP	HPRD, IntAct, BioGRID	empirical	11741830 21988832
SMAD4	UHRF2	HPRD, MINT	empirical	15231748
SMAD4	PARD3B	BioGRID	empirical	12650946
SMAD4	RHEBL1	HPRD, MINT	empirical	15761153
SMAD4	UHMK1	BioGRID	empirical	15761153
SMAD4	ATF2	HPRD, BioGRID	empirical	10085140
SMAD4	CREBBP	HPRD	empirical	9679056
SMAD4	GATA5	BioGRID	empirical	14662776
SMAD4	STK35	HPRD, BioGRID	empirical	15761153
SMAD4	CSH1	MINT	empirical	15231748
SMAD4	NKX2-5	BioGRID	empirical	21152044
SMAD4	CTNNB1	HPRD, BioGRID	empirical	12000714
SMAD4	DACH1	HPRD, IntAct	empirical	14525983
SMAD4	DAXX	BioGRID	empirical	15637079
SMAD4	AP2B1	HPRD, BioGRID	empirical	15761153
SMAD4	EID2	HPRD, BioGRID	empirical	14612439
SMAD4	DLX1	HPRD, BioGRID	empirical	14671321
SMAD4	DLX4	IntAct	empirical	21297662
SMAD4	DVL1	HPRD, MINT	empirical	12650946
SMAD4	EEF1A1	HPRD, MINT	empirical	15231748
SMAD4	DCP1B	HPRD, MINT	empirical	15231748
SMAD4	EP300	HPRD, BioGRID	empirical	9843571 10887155 18215124 9679056
SMAD4	AKT1	HPRD, MINT, BioGRID	empirical	16362038
SMAD4	ESR1	HPRD	empirical	11555647 12576474
SMAD4	ESR2	HPRD	empirical	11555647
SMAD4	MECOM	BioGRID	empirical	15849193
SMAD4	EWSR1	HPRD, MINT, IntAct, BioGRID	empirical	16189514
SMAD4	F2RL2	MINT	empirical	12650946
SMAD4	FBLN1	HPRD, MINT	empirical	15231748
SMAD4	ARL5B	HPRD, MINT, BioGRID	empirical	15761153
SMAD4	RRAS2	HPRD, BioGRID	empirical	15761153
SMAD4	FOXG1	HPRD	empirical	11387330
SMAD4	SNW1	BioGRID	empirical	11278756
SMAD4	FOXO1	HPRD, BioGRID	empirical	15084259
SMAD4	TRIM35	BioGRID	empirical	15761153
SMAD4	FOXO3	HPRD, IntAct, BioGRID	empirical	15084259 21532621
SMAD4	ZNF423	HPRD, BioGRID	empirical	10660046
SMAD4	KDM6B	BioGRID	empirical	20667911
SMAD4	FN1	HPRD, IntAct	empirical	15231748 21988832
SMAD4	RASD2	HPRD, BioGRID	empirical	15761153
SMAD4	RAB38	HPRD, BioGRID	empirical	15761153
SMAD4	ZNF521	HPRD	empirical	14630787
SMAD4	SIN3A	BioGRID	empirical	17226765
SMAD4	GATA2	IntAct, BioGRID	empirical	21988832 20211142
SMAD4	GATA4	BioGRID	empirical	14662776
SMAD4	GATA6	BioGRID	empirical	14662776
SMAD4	CYFIP2	IntAct	empirical	21988832
SMAD4	FOXP1	BioGRID	empirical	20211142
SMAD4	RTDR1	HPRD, BioGRID	empirical	15761153
SMAD4	GLI3	HPRD	empirical	9843199
SMAD4	RHOD	HPRD, MINT	empirical	15761153
SMAD4	TLX3	BioGRID	empirical	20211142
SMAD4	HDAC1	BioGRID	empirical	17226765 14699069
SMAD4	HDGF	HPRD, BioGRID	empirical	15761153
SMAD4	HDLBP	HPRD, MINT	empirical	15231748
SMAD4	HNF4A	HPRD, BioGRID	empirical	10995777
SMAD4	HOXA9	HPRD, BioGRID	empirical	11042172
SMAD4	HOXC8	HPRD, BioGRID	empirical	10224145
SMAD4	APBB2	HPRD, BioGRID	empirical	15761153
SMAD4	APC	BioGRID	empirical	11197776 10708962 9506519 10626800
SMAD4	DNAJB2	HPRD, MINT	empirical	15231748
SMAD4	HSP90AB1	Sanger Interaction Map	predicted	15345047
SMAD4	AR	HPRD	empirical	12226080
SMAD4	ITK	HPRD, BioGRID	empirical	15761153
SMAD4	JUN	HPRD	empirical	10220381
SMAD4	JUNB	HPRD, MINT, BioGRID	empirical	10220381 15231748
SMAD4	JUND	HPRD	empirical	10220381
SMAD4	KPNB1	BioGRID	empirical	10846168
SMAD4	RHOG	HPRD, BioGRID	empirical	15761153
SMAD4	SMAD1	HPRD, MINT, BioGRID, Reactome	empirical	15761153 15231748 17183365 12874272 10531362 11700304 12167862 21454478 14701756 12592392 11509558 12821673 11121043 11779505 8893010
SMAD4	SMAD2	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	11274206 12167862 15231748 15350224 18511908 19135894 18729074 21988832 21297662 21532621 15761153 12794086 10199400 11264182 12419246 9311995 11027280 9288972 10531362 9892009 11114293 11102446 18783722 15817471 12808092 12732634 12672795 10781087 21454478 16751102 10085121 10878024 10549282 11779505 9670020 12592392 10934479 11294908
SMAD4	SMAD3	HPRD, MINT, IntAct, MIPS, BioGRID, Reactome	empirical	9311995 10995777 15231748 15350224 19135894 18729074 21988832 21297662 21532621 22036565 9111321 15761153 15084259 12794086 12419246 10531362 9892009 11114293 20142324 17226765 12732634 12672795 12167862 20564330 22045334 10878024 12917407 10549282 11779505 9670020 12592392 10934479 11294908
SMAD4	SMAD4	HPRD, IntAct, MIPS	empirical	10647180 11224571 9111321 21988832
SMAD4	SMAD5	HPRD, MINT, BioGRID, Reactome	empirical	15231748 10531362 12592392 11509558 12821673 11121043 11779505 8893010
SMAD4	SMAD6	BioGRID	empirical	9256479 15817471
SMAD4	SMAD7	BioGRID	empirical	9892009 15817471 17438144
SMAD4	SMAD9	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	16189514 15231748 10583507 12592392 11509558 12821673 11121043 11779505 8893010
SMAD4	MAX	HPRD, BioGRID	empirical	12551947
SMAD4	MDM4	BioGRID	empirical	12483531
SMAD4	MEF2A	HPRD	empirical	11160896
SMAD4	FOXO4	HPRD, BioGRID	empirical	15084259
SMAD4	EIF2AK4	HPRD, BioGRID	empirical	15761153
SMAD4	CITED1	HPRD, BioGRID	empirical	9707553
SMAD4	MYOD1	HPRD, MINT	empirical	15231748
SMAD4	NF1	BioGRID	empirical	18215124
SMAD4	NOTCH4	HPRD	empirical	16007227
SMAD4	NRAS	HPRD, BioGRID	empirical	15761153
SMAD4	PAK1	HPRD	empirical	15761153
SMAD4	LEF1	HPRD, BioGRID	empirical	10890911
SMAD4	RASL12	HPRD	empirical	15761153
SMAD4	ECSIT	HPRD	empirical	14633973
SMAD4	RNF138	BioGRID	empirical	15761153
SMAD4	TH1L	HPRD, MINT	empirical	15231748
SMAD4	MED15	MINT	empirical	12167862
SMAD4	PIAS4	HPRD, BioGRID	empirical	12904571 12815042 12740389
SMAD4	TRIM33	IntAct, BioGRID	empirical	19135894 20603019 21726812
SMAD4	NLK	IntAct	empirical	21988832
SMAD4	PGGT1B	Sanger Interaction Map	predicted	15345047
SMAD4	SERPINA1	IntAct	empirical	21988832
SMAD4	PLG	IntAct	empirical	21988832
SMAD4	SASH3	HPRD, MINT	empirical	15761153
SMAD4	FBXO34	HPRD	empirical	15761153
SMAD4	PRPF40A	HPRD, MINT	empirical	15231748
SMAD4	ODZ3	HPRD, MINT	empirical	15231748
SMAD4	ATF7IP	HPRD, MINT, IntAct	empirical	15231748 21988832
SMAD4	PRKAR1B	HPRD	empirical	14966294
SMAD4	PRKAR2A	HPRD	empirical	14966294
SMAD4	DCP1A	HPRD, MINT, BioGRID	empirical	11836524 15231748
SMAD4	PBK	HPRD, MINT, BioGRID	empirical	15761153
SMAD4	ERBB2IP	HPRD, MINT, BioGRID	empirical	12650946
SMAD4	MAPK1	HPRD	empirical	12801888
SMAD4	MAPK13	HPRD, MINT	empirical	15231748
SMAD4	MAP2K3	BioGRID	empirical	15761153
SMAD4	PARD3	HPRD	empirical	12650946
SMAD4	EIF4ENIF1	MIPS	empirical	14651998
SMAD4	PSG2	HPRD, MINT	empirical	15231748
SMAD4	PSG9	HPRD, MINT	empirical	15231748
SMAD4	RAB25	HPRD	empirical	15761153
SMAD4	SMURF1	BioGRID	empirical	15817471
SMAD4	PSMD11	HPRD, MINT	empirical	15231748
SMAD4	RHOJ	HPRD, BioGRID	empirical	15761153
SMAD4	XPO5	HPRD, MINT	empirical	15231748
SMAD4	NKX3-2	BioGRID	empirical	14612411
SMAD4	ZBED5	HPRD, MINT	empirical	15231748
SMAD4	RAB3B	HPRD, MINT, BioGRID	empirical	15761153
SMAD4	RAB13	HPRD, MINT, BioGRID	empirical	15761153
SMAD4	RAC2	HPRD, BioGRID	empirical	15761153
SMAD4	RALA	HPRD, MINT	empirical	15231748
SMAD4	RBL1	HPRD	empirical	12150994
SMAD4	RELA	IntAct	empirical	21988832
SMAD4	RFX1	HPRD, MINT	empirical	15231748
SMAD4	PAPPA2	HPRD, MINT	empirical	15231748
SMAD4	RPL28	HPRD, MINT	empirical	15231748
SMAD4	RPS27A	HPRD	empirical	15761153
SMAD4	RMND5B	HPRD, MINT	empirical	15231748
SMAD4	SKI	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	12857746 12419246 15231748 14525983 12874272 10531062 19032343 12732634 14699069 20959473 11121043 10549282
SMAD4	SKIL	HPRD, MINT, BioGRID	empirical	10531062 15231748
SMAD4	SKP2	BioGRID	empirical	16865698 15314162
SMAD4	UBE2Z	HPRD	empirical	15761153
SMAD4	SMARCD3	BioGRID	empirical	15525990
SMAD4	SNAI1	BioGRID	empirical	19597490
SMAD4	SNRNP70	HPRD, MINT	empirical	15231748
SMAD4	SOX12	IntAct	empirical	21988832
SMAD4	SP1	HPRD, IntAct, BioGRID	empirical	11114293 10878024 21297662 18215124
SMAD4	SPTBN1	HPRD	empirical	12543979
SMAD4	BRCA1	HPRD	empirical	15735739
SMAD4	STAT1	BioGRID	empirical	15761153
SMAD4	TCTA	HPRD, MINT	empirical	15231748
SMAD4	TDG	HPRD, MINT	empirical	15231748
SMAD4	TFE3	HPRD, BioGRID	empirical	10557285 12551947
SMAD4	TGFBR1	HPRD	empirical	8774881
SMAD4	TGFBR2	HPRD	empirical	8774881
SMAD4	UBA52	HPRD	empirical	15761153
SMAD4	UBB	HPRD	empirical	15761153
SMAD4	UBC	BioGRID	empirical	16865698 15855639 15817471 15314162 12813045 10781087 21139048 21890473
SMAD4	UBE2I	HPRD, MINT, IntAct, BioGRID	empirical	12621041 15231748 16189514 21988832 15637079
SMAD4	UBE2L3	HPRD	empirical	12794086
SMAD4	YY1	BioGRID	empirical	12808092
SMAD4	ZNF8	HPRD, BioGRID	empirical	12370310
SMAD4	ZMYM2	HPRD, MINT	empirical	15231748
SMAD4	C16orf57	HPRD, MINT	empirical	15231748
SMAD4	SNIP1	HPRD, BioGRID	empirical	10887155
SMAD4	NUP214	HPRD, BioGRID	empirical	12917407
SMAD4	ILKAP	BioGRID	empirical	15761153
SMAD4	TSSK3	HPRD, BioGRID	empirical	15761153
SMAD4	NUAK2	HPRD, BioGRID	empirical	15761153
SMAD4	CAMK2G	HPRD, BioGRID	empirical	11027280
SMAD4	USP9X	HPRD, IntAct, BioGRID	empirical	19135894
SMAD4	RAB34	HPRD, BioGRID	empirical	15761153
SMAD4	FBXO30	HPRD, MINT	empirical	15761153
SMAD4	MEX3B	HPRD	empirical	15761153
SMAD4	NR0B2	IntAct	empirical	21988832
SMAD4	RAB2B	HPRD, BioGRID	empirical	15761153
SMAD4	PIAS1	HPRD, MINT, IntAct	empirical	15028714 15231748 21988832
SMAD4	RIPK2	HPRD	empirical	15761153
SMAD4	ARHGEF7	BioGRID	empirical	15761153
SMAD4	SQSTM1	HPRD, BioGRID	empirical	15761153
SMAD4	FOXH1	HPRD, BioGRID	empirical	9288972
SMAD4	BTRC	HPRD, BioGRID	empirical	14988407 16865698 15855639 15314162
SMAD4	NAT8	HPRD, MINT	empirical	15761153
SMAD4	PIAS2	HPRD	empirical	14514699
SMAD4	ACVR1B	HPRD	empirical	9892009
SMAD4	TM9SF2	HPRD, MINT	empirical	15231748
SMAD4	TGFBRAP1	HPRD	empirical	11278302
SMAD4	RNF14	BioGRID	empirical	15761153
SMAD4	CD59	HPRD, MINT	empirical	15231748
SMAD4	ARHGEF11	BioGRID	empirical	15761153
SMAD4	USP15	BioGRID	empirical	21947082