ARRB1

Summary Top Help

Gene Description:

arrestin, beta 1

Synonyms:

ARR1, Arrb1, AW208571, ARB1, 1200006I17Rik, G430100A01Rik, ARRB1, BARRES

Orthologs:

Human ARRB1 (protein-coding), Mouse Arrb1 (protein-coding), Rat Arrb1 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd27	Mouse	chr7:86521272..127029671	40.51	634

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:74971166..75062875 (91.71 kb) View in Genome Browser

(Mouse) NCBIM37 - chr7:106683976..106755281 (71.31 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:156871562..156937540 (65.98 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for ARRB1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
			no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for ARRB1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 4

Biocarta: 4

Reactome: 10

NCI-Nature Pathway Interaction Database: 5

Gene Ontology: 46

Golgi membrane	GO:0000139
Chromatin	GO:0000785
G-protein coupled receptor internalization	GO:0002031
Histone acetyltransferase activity	GO:0004402
Enzyme inhibitor activity	GO:0004857
GTPase activator activity	GO:0005096
Insulin-like growth factor receptor binding	GO:0005159
Protein binding	GO:0005515
Membrane fraction	GO:0005624
Soluble fraction	GO:0005625
Nucleus	GO:0005634
Cytoplasm	GO:0005737
Lysosomal membrane	GO:0005765
Cytosol	GO:0005829
Heterotrimeric G-protein complex	GO:0005834
Plasma membrane	GO:0005886
Coated pit	GO:0005905
Regulation of transcription, DNA-dependent	GO:0006355
Transcription from RNA polymerase II promoter	GO:0006366
Post-Golgi vesicle-mediated transport	GO:0006892
Blood coagulation	GO:0007596
Transcription factor binding	GO:0008134
Negative regulation of signal transduction	GO:0009968
Protein transport	GO:0015031
Cellular membrane organization	GO:0016044
Protein ubiquitination	GO:0016567
Platelet activation	GO:0030168
Cytoplasmic vesicle membrane	GO:0030659
Pseudopodium	GO:0031143
Negative regulation of protein ubiquitination	GO:0031397
Cytoplasmic vesicle	GO:0031410
Ubiquitin protein ligase binding	GO:0031625
Angiotensin receptor binding	GO:0031701
Negative regulation of NF-kappaB transcription factor activity	GO:0032088
Negative regulation of interleukin-6 production	GO:0032715
Negative regulation of interleukin-8 production	GO:0032717
Positive regulation of Rho protein signal transduction	GO:0035025
Positive regulation of histone acetylation	GO:0035066
Negative regulation of catalytic activity	GO:0043086
Stress fiber assembly	GO:0043149
Proteasomal ubiquitin-dependent protein catabolic process	GO:0043161
Positive regulation of GTPase activity	GO:0043547
Histone H4 acetylation	GO:0043967
Transcription regulatory region DNA binding	GO:0044212
Positive regulation of transcription from RNA polymerase II promoter	GO:0045944
Positive regulation of ERK1 and ERK2 cascade	GO:0070374

Publications from PubMed Top Help

Type 1 Diabetes Publications: 3

Publications: 277

Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds.
Soh UJ, Trejo J
Proc Natl Acad Sci U S A. 2011
PubMed ID: 22106258
Gender related alterations of β-adrenoceptor mechanisms in heart failure due to arteriovenous fistula.
Dent MR, Tappia PS, Dhalla NS
J Cell Physiol. 2011
PubMed ID: 22015551
Increased expression of beta-arrestin 1 and 2 in murine models of rheumatoid arthritis: isoform specific regulation of inflammation.
Li P, Cook JA, Gilkeson GS, Luttrell LM, Wang L, Borg KT, Halushka PV, Fan H
Mol Immunol. 2011
PubMed ID: 21855149
Rapid dephosphorylation of G protein-coupled receptors by protein phosphatase 1β is required for termination of β-arrestin-dependent signaling.
Pöll F, Doll C, Schulz S
J Biol Chem. 2011
PubMed ID: 21795688
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ
Nature. 2011
PubMed ID: 21857681
Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation.
Groer CE, Schmid CL, Jaeger AM, Bohn LM
J Biol Chem. 2011
PubMed ID: 21757712
Disruption of β-arrestins blocks glucocorticoid receptor and severely retards lung and liver development in mice.
Zhang M, Teng H, Shi J, Zhang Y
Mech Dev. 2011
PubMed ID: 21824517
Beta-arrestin-1 protein represses adipogenesis and inflammatory responses through its interaction with peroxisome proliferator-activated receptor-gamma (PPARgamma).
Zhuang LN, Hu WX, Xin SM, Zhao J, Pei G
J Biol Chem. 2011
PubMed ID: 21700709
Beta-arrestin-1 protein represses diet-induced obesity.
Zhuang LN, Hu WX, Zhang ML, Xin SM, Jia WP, Zhao J, Pei G
J Biol Chem. 2011
PubMed ID: 21543334
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
The beta-arrestin pathway-selective type 1A angiotensin receptor (AT1A) agonist [Sar1,Ile4,Ile8]angiotensin II regulates a robust G protein-independent signaling network.
Kendall RT, Strungs EG, Rachidi SM, Lee MH, El-Shewy HM, Luttrell DK, Janech MG, Luttrell LM
J Biol Chem. 2011
PubMed ID: 21502318
EGFR trans-activation by urotensin II receptor is mediated by β-arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy.
Esposito G, Perrino C, Cannavo A, Schiattarella GG, Borgia F, Sannino A, Pironti G, Gargiulo G, Di Serafino L, Franzone A, Scudiero L, Grieco P, Indolfi C, Chiariello M
Basic Res Cardiol. 2011
PubMed ID: 21369867
β-Arrestin 1 modulates functions of autoimmune T cells from primary biliary cirrhosis patients.
Hu Z, Huang Y, Liu Y, Sun Y, Zhou Y, Gu M, Chen Y, Xia R, Chen S, Deng A, Zhong R
J Clin Immunol. 2011
PubMed ID: 21243522
Ubiquitin ligase parkin promotes Mdm2-arrestin interaction but inhibits arrestin ubiquitination.
Ahmed MR, Zhan X, Song X, Kook S, Gurevich VV, Gurevich EV
Biochemistry. 2011
PubMed ID: 21466165
Elevated β-arrestin1 expression correlated with risk stratification in acute lymphoblastic leukemia.
Liu H, Long J, Zhang PH, Li K, Tan JJ, Sun B, Yu J, Tu ZG, Zou L
Int J Hematol. 2011
PubMed ID: 21479985
Neurotensin triggers dopamine D2 receptor desensitization through a protein kinase C and beta-arrestin1-dependent mechanism.
Thibault D, Albert PR, Pineyro G, Trudeau LÉ
J Biol Chem. 2011
PubMed ID: 21233215
β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix.
Lovgren AK, Kovacs JJ, Xie T, Potts EN, Li Y, Foster WM, Liang J, Meltzer EB, Jiang D, Lefkowitz RJ, Noble PW
Sci Transl Med. 2011
PubMed ID: 21411739
β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration.
Grotegut CA, Feng L, Mao L, Heine RP, Murtha AP, Rockman HA
Am J Physiol Endocrinol Metab. 2011
PubMed ID: 21139074
ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors.
Dasgupta P, Rizwani W, Pillai S, Davis R, Banerjee S, Hug K, Lloyd M, Coppola D, Haura E, Chellappan SP
J Natl Cancer Inst. 2011
PubMed ID: 21212384
Interaction of profilin-1 and F-actin via a β-arrestin-1/JNK signaling pathway involved in prostaglandin E(2)-induced human mesenchymal stem cells migration and proliferation.
Yun SP, Ryu JM, Jang MW, Han HJ
J Cell Physiol. 2011
PubMed ID: 20717968
The expression change of β-arrestins in fibroblast-like synoviocytes from rats with collagen-induced arthritis and the effect of total glucosides of paeony.
Wang QT, Zhang LL, Wu HX, Wei W
J Ethnopharmacol. 2011
PubMed ID: 20965243
Adrenal beta-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels.
Lymperopoulos A, Rengo G, Zincarelli C, Kim J, Koch WJ
J Am Coll Cardiol. 2011
PubMed ID: 21232674
Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2.
Nogués L, Salcedo A, Mayor F, Penela P
J Biol Chem. 2011
PubMed ID: 21081496
Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins.
Lima-Fernandes E, Enslen H, Camand E, Kotelevets L, Boularan C, Achour L, Benmerah A, Gibson LC, Baillie GS, Pitcher JA, Chastre E, Etienne-Manneville S, Marullo S, Scott MG
EMBO J. 2011
PubMed ID: 21642958
Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells.
Vibhuti A, Gupta K, Subramanian H, Guo Q, Ali H
PLoS One. 2011
PubMed ID: 21589858
β-Arrestin1 mediates the endocytosis and functions of macrophage migration inhibitory factor.
Xie L, Qiao X, Wu Y, Tang J
PLoS One. 2011
PubMed ID: 21283538
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Preferential β-arrestin signalling at low receptor density revealed by functional characterization of the human FSH receptor A189 V mutation.
Tranchant T, Durand G, Gauthier C, Crépieux P, Ulloa-Aguirre A, Royère D, Reiter E
Mol Cell Endocrinol. 2011
PubMed ID: 20801186
The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways.
Chun KS, Lao HC, Langenbach R
J Biol Chem. 2010
PubMed ID: 20959465
The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7: roles of receptor domains.
Gravel S, Malouf C, Boulais PE, Berchiche YA, Oishi S, Fujii N, Leduc R, Sinnett D, Heveker N
J Biol Chem. 2010
PubMed ID: 20956518
Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H+ exchanger 1 ubiquitylation, endocytosis, and function.
Simonin A, Fuster D
J Biol Chem. 2010
PubMed ID: 20855896
Regulation of lipopolysaccharide-induced inflammatory response and endotoxemia by beta-arrestins.
Porter KJ, Gonipeta B, Parvataneni S, Appledorn DM, Patial S, Sharma D, Gangur V, Amalfitano A, Parameswaran N
J Cell Physiol. 2010
PubMed ID: 20589830
[Pathogenetic mechanism of beta-arrestin1 in experimental colitis of rats and intervention effects of oxymatrine].
Liao Y, Fan H, Chen XY
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010
PubMed ID: 21066892
A human MAP kinase interactome.
Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
Nat Methods. 2010
PubMed ID: 20936779
β-Arrestin-1 links mitogenic sonic hedgehog signaling to the cell cycle exit machinery in neural precursors.
Parathath SR, Mainwaring LA, Fernandez-L A, Guldal CG, Nahlé Z, Kenney AM
Cell Cycle. 2010
PubMed ID: 20935513
Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4.
Shukla AK, Kim J, Ahn S, Xiao K, Shenoy SK, Liedtke W, Lefkowitz RJ
J Biol Chem. 2010
PubMed ID: 20650893
Beta-arrestin-1 mediates the endothelin-1-induced activation of Akt and integrin-linked kinase.
Cianfrocca R, Rosanò L, Spinella F, Di Castro V, Natali PG, Bagnato A
Can J Physiol Pharmacol. 2010
PubMed ID: 20725137
Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4.
Malik R, Marchese A
Mol Biol Cell. 2010
PubMed ID: 20505072
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
beta-Arrestins scaffold cofilin with chronophin to direct localized actin filament severing and membrane protrusions downstream of protease-activated receptor-2.
Zoudilova M, Min J, Richards HL, Carter D, Huang T, DeFea KA
J Biol Chem. 2010
PubMed ID: 20207744
beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation.
Mangmool S, Shukla AK, Rockman HA
J Cell Biol. 2010
PubMed ID: 20421423
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with beta-arrestin.
Lee DK, Ferguson SS, George SR, O'Dowd BF
Biochem Biophys Res Commun. 2010
PubMed ID: 20353754
Prostaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsome.
Kim JI, Lakshmikanthan V, Frilot N, Daaka Y
Mol Cancer Res. 2010
PubMed ID: 20353998
Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex.
Bjørgo E, Solheim SA, Abrahamsen H, Baillie GS, Brown KM, Berge T, Okkenhaug K, Houslay MD, Taskén K
Mol Cell Biol. 2010
PubMed ID: 20086095
Loss of betaarrestin1 and betaarrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice.
Zhang M, Liu X, Zhang Y, Zhao J
Dev Biol. 2010
PubMed ID: 20060823
Control of rhodopsin's active lifetime by arrestin-1 expression in mammalian rods.
Gross OP, Burns ME
J Neurosci. 2010
PubMed ID: 20203204
Custom-designed proteins as novel therapeutic tools? The case of arrestins.
Gurevich VV, Gurevich EV
Expert Rev Mol Med. 2010
PubMed ID: 20412604
beta-Arrestins modulate Adenovirus-vector-induced innate immune responses: differential regulation by beta-arrestin-1 and beta-arrestin-2.
Seregin SS, Appledorn DM, Patial S, Bujold M, Nance W, Godbehere S, Parameswaran N, Amalfitano A
Virus Res. 2010
PubMed ID: 19896992
Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2.
García Lopez MA, Aguado Martínez A, Lamaze C, Martínez-A C, Fischer T
Cell Signal. 2009
PubMed ID: 19643177
Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression.
Yue R, Kang J, Zhao C, Hu W, Tang Y, Liu X, Pei G
Cell. 2009
PubMed ID: 19879840
A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex.
Li X, MacLeod R, Dunlop AJ, Edwards HV, Advant N, Gibson LC, Devine NM, Brown KM, Adams DR, Houslay MD, Baillie GS
FEBS Lett. 2009
PubMed ID: 19782076
An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages.
Cheung R, Malik M, Ravyn V, Tomkowicz B, Ptasznik A, Collman RG
J Leukoc Biol. 2009
PubMed ID: 19620252
Arrestin competition influences the kinetics and variability of the single-photon responses of mammalian rod photoreceptors.
Doan T, Azevedo AW, Hurley JB, Rieke F
J Neurosci. 2009
PubMed ID: 19776273
Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.
Barthet G, Carrat G, Cassier E, Barker B, Gaven F, Pillot M, Framery B, Pellissier LP, Augier J, Kang DS, Claeysen S, Reiter E, Banères JL, Benovic JL, Marin P, Bockaert J, Dumuis A
EMBO J. 2009
PubMed ID: 19661922
The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development.
Chun KS, Lao HC, Trempus CS, Okada M, Langenbach R
Carcinogenesis. 2009
PubMed ID: 19587094
Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling.
Cottrell GS, Padilla BE, Amadesi S, Poole DP, Murphy JE, Hardt M, Roosterman D, Steinhoff M, Bunnett NW
J Biol Chem. 2009
PubMed ID: 19531493
beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling.
Tilley DG, Kim IM, Patel PA, Violin JD, Rockman HA
J Biol Chem. 2009
PubMed ID: 19509284
Beta-arrestin/Ral signaling regulates lysophosphatidic acid-mediated migration and invasion of human breast tumor cells.
Li TT, Alemayehu M, Aziziyeh AI, Pape C, Pampillo M, Postovit LM, Mills GB, Babwah AV, Bhattacharya M
Mol Cancer Res. 2009
PubMed ID: 19609003
beta-Arrestins facilitate ubiquitin-dependent degradation of apoptosis signal-regulating kinase 1 (ASK1) and attenuate H2O2-induced apoptosis.
Zhang Z, Hao J, Zhao Z, Ben P, Fang F, Shi L, Gao Y, Liu J, Wen C, Luo L, Yin Z
Cell Signal. 2009
PubMed ID: 19306926
Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5.
Li X, Baillie GS, Houslay MD
J Biol Chem. 2009
PubMed ID: 19372219
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, for the MrOS Research Group
J Bone Miner Res. 2009
PubMed ID: 19453261
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Dephosphorylation of beta-arrestin 1 in glioblastomas.
Mandell JW, Glass G, Gianchandani EP, Locke CN, Amos S, Bourne TD, Schiff D, Papin JA
J Neuropathol Exp Neurol. 2009
PubMed ID: 19404096
beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.
Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ
J Clin Invest. 2009
PubMed ID: 19349687
Prolonged RXFP1 and RXFP2 signaling can be explained by poor internalization and a lack of beta-arrestin recruitment.
Callander GE, Thomas WG, Bathgate RA
Am J Physiol Cell Physiol. 2009
PubMed ID: 19279230
Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor.
Kim J, Ahn S, Rajagopal K, Lefkowitz RJ
J Biol Chem. 2009
PubMed ID: 19254952
GRK mythology: G-protein receptor kinases in cardiovascular disease.
Dorn GW
J Mol Med (Berl). 2009
PubMed ID: 19229505
Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation.
Song X, Vishnivetskiy SA, Gross OP, Emelianoff K, Mendez A, Chen J, Gurevich EV, Burns ME, Gurevich VV
Curr Biol. 2009
PubMed ID: 19361994
MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
Meng D, Lynch MJ, Huston E, Beyermann M, Eichhorst J, Adams DR, Klusmann E, Houslay MD, Baillie GS
J Biol Chem. 2009
PubMed ID: 19153083
Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.
Shenoy SK, Modi AS, Shukla AK, Xiao K, Berthouze M, Ahn S, Wilkinson KD, Miller WE, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19363159
An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo.
Lymperopoulos A, Rengo G, Zincarelli C, Kim J, Soltys S, Koch WJ
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19289825
17beta-estradiol-mediated neuroprotection and ERK activation require a pertussis toxin-sensitive mechanism involving GRK2 and beta-arrestin-1.
Dominguez R, Hu E, Zhou M, Baudry M
J Neurosci. 2009
PubMed ID: 19339617
{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation.
Ahn S, Kim J, Hara MR, Ren XR, Lefkowitz RJ
J Biol Chem. 2009
PubMed ID: 19171933
c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms.
Lodeiro M, Theodoropoulou M, Pardo M, Casanueva FF, Camiña JP
PLoS One. 2009
PubMed ID: 19262695
beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation.
Yang M, He RL, Benovic JL, Ye RD
Biochem J. 2009
PubMed ID: 18729826
Roles of G protein and beta-arrestin in dopamine D2 receptor-mediated ERK activation.
Quan W, Kim JH, Albert PR, Choi H, Kim KM
Biochem Biophys Res Commun. 2008
PubMed ID: 18940181
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways.
Bryja V, Schambony A, Cajánek L, Dominguez I, Arenas E, Schulte G
EMBO Rep. 2008
PubMed ID: 18953287
Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2.
Hoffmann C, Ziegler N, Reiner S, Krasel C, Lohse MJ
J Biol Chem. 2008
PubMed ID: 18703513
Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling.
Labasque M, Reiter E, Becamel C, Bockaert J, Marin P
Mol Biol Cell. 2008
PubMed ID: 18768750
A novel protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2-adrenergic receptors.
Gong K, Li Z, Xu M, Du J, Lv Z, Zhang Y
J Biol Chem. 2008
PubMed ID: 18678875
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Nuclear beta-arrestin1 functions as a scaffold for the dephosphorylation of STAT1 and moderates the antiviral activity of IFN-gamma.
Mo W, Zhang L, Yang G, Zhai J, Hu Z, Chen Y, Chen X, Hui L, Huang R, Hu G
Mol Cell. 2008
PubMed ID: 18775329
Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50.
Stanasila L, Abuin L, Dey J, Cotecchia S
Mol Pharmacol. 2008
PubMed ID: 18523139
Mouse cones require an arrestin for normal inactivation of phototransduction.
Nikonov SS, Brown BM, Davis JA, Zuniga FI, Bragin A, Pugh EN, Craft CM
Neuron. 2008
PubMed ID: 18701071
Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor.
Shenoy SK, Xiao K, Venkataramanan V, Snyder PM, Freedman NJ, Weissman AM
J Biol Chem. 2008
PubMed ID: 18544533
Site-specific cleavage of G protein-coupled receptor-engaged beta-arrestin. Influence of the AT1 receptor conformation on scissile site selection.
Lee C, Bhatt S, Shukla A, Desnoyer RW, Yadav SP, Kim M, Jang SH, Karnik SS
J Biol Chem. 2008
PubMed ID: 18505723
Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor.
Nelson CD, Kovacs JJ, Nobles KN, Whalen EJ, Lefkowitz RJ
J Biol Chem. 2008
PubMed ID: 18534983
Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration.
Kim J, Zhang L, Peppel K, Wu JH, Zidar DA, Brian L, DeWire SM, Exum ST, Lefkowitz RJ, Freedman NJ
Circ Res. 2008
PubMed ID: 18519945
Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms.
Zhang X, Wang F, Chen X, Chen Y, Ma L
J Neurochem. 2008
PubMed ID: 18419762
Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle.
Deshpande DA, Theriot BS, Penn RB, Walker JK
FASEB J. 2008
PubMed ID: 18337459
Beta-arrestin-mediated localization of smoothened to the primary cilium.
Kovacs JJ, Whalen EJ, Liu R, Xiao K, Kim J, Chen M, Wang J, Chen W, Lefkowitz RJ
Science. 2008
PubMed ID: 18497258
Quantal noise from human red cone pigment.
Fu Y, Kefalov V, Luo DG, Xue T, Yau KW
Nat Neurosci. 2008
PubMed ID: 18425122
Beta-arrestin-mediated signaling regulates protein synthesis.
DeWire SM, Kim J, Whalen EJ, Ahn S, Chen M, Lefkowitz RJ
J Biol Chem. 2008
PubMed ID: 18276584
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Beta-arrestins 1 and 2 are associated with nicotine dependence in European American smokers.
Sun D, Ma JZ, Payne TJ, Li MD
Mol Psychiatry. 2008
PubMed ID: 17579607
Beta-arrestins: multifunctional cellular mediators.
Barki-Harrington L, Rockman HA
Physiology (Bethesda). 2008
PubMed ID: 18268361
Rapid xenograft tumor progression in beta-arrestin1 transgenic mice due to enhanced tumor angiogenesis.
Zou L, Yang R, Chai J, Pei G
FASEB J. 2008
PubMed ID: 17890288
Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription.
Lee MH, El-Shewy HM, Luttrell DK, Luttrell LM
J Biol Chem. 2008
PubMed ID: 18006496
Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4.
Bhandari D, Trejo J, Benovic JL, Marchese A
J Biol Chem. 2007
PubMed ID: 17947233
A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducin.
Brill E, Malanson KM, Radu RA, Boukharov NV, Wang Z, Chung HY, Lloyd MB, Bok D, Travis GH, Obin M, Lem J
Invest Ophthalmol Vis Sci. 2007
PubMed ID: 18055791
1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.
Smith KJ, Baillie GS, Hyde EI, Li X, Houslay TM, McCahill A, Dunlop AJ, Bolger GB, Klussmann E, Adams DR, Houslay MD
Cell Signal. 2007
PubMed ID: 17900862
Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110 alpha and beta by protease-activated receptor 2 and beta-arrestins.
Wang P, Kumar P, Wang C, Defea KA
Biochem J. 2007
PubMed ID: 17680774
Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
Cao L, Yu K, Banh C, Nguyen V, Ritz A, Raphael BJ, Kawakami Y, Kawakami T, Salomon AR
J Immunol. 2007
PubMed ID: 17947660
Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.
Shenoy SK, Barak LS, Xiao K, Ahn S, Berthouze M, Shukla AK, Luttrell LM, Lefkowitz RJ
J Biol Chem. 2007
PubMed ID: 17666399
Tumor necrosis factor receptor-1 can function through a G alpha q/11-beta-arrestin-1 signaling complex.
Kawamata Y, Imamura T, Babendure JL, Lu JC, Yoshizaki T, Olefsky JM
J Biol Chem. 2007
PubMed ID: 17664271
Signaling properties of a short-wave cone visual pigment and its role in phototransduction.
Shi G, Yau KW, Chen J, Kefalov VJ
J Neurosci. 2007
PubMed ID: 17881515
The role of beta-arrestins in the formyl peptide receptor-like 1 internalization and signaling.
Huet E, Boulay F, Barral S, Rabiet MJ
Cell Signal. 2007
PubMed ID: 17594911
The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network.
Bouschet T, Martin S, Kanamarlapudi V, Mundell S, Henley JM
J Cell Sci. 2007
PubMed ID: 17623778
Critical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1.
Shi Y, Feng Y, Kang J, Liu C, Li Z, Li D, Cao W, Qiu J, Guo Z, Bi E, Zang L, Lu C, Zhang JZ, Pei G
Nat Immunol. 2007
PubMed ID: 17618287
Beta-arrestin-dependent parathyroid hormone-stimulated extracellular signal-regulated kinase activation and parathyroid hormone type 1 receptor internalization.
Sneddon WB, Friedman PA
Endocrinology. 2007
PubMed ID: 17525124
The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2.
Nobles KN, Guan Z, Xiao K, Oas TG, Lefkowitz RJ
J Biol Chem. 2007
PubMed ID: 17513300
Functional specialization of beta-arrestin interactions revealed by proteomic analysis.
Xiao K, McClatchy DB, Shukla AK, Zhao Y, Chen M, Shenoy SK, Yates JR, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17620599
Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2.
Zoudilova M, Kumar P, Ge L, Wang P, Bokoch GM, DeFea KA
J Biol Chem. 2007
PubMed ID: 17500066
Differential effects of beta-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2.
Kumar P, Lau CS, Mathur M, Wang P, DeFea KA
Am J Physiol Cell Physiol. 2007
PubMed ID: 17442737
Enolase and arrestin are novel nonmyelin autoantigens in multiple sclerosis.
Forooghian F, Cheung RK, Smith WC, O'Connor P, Dosch HM
J Clin Immunol. 2007
PubMed ID: 17436063
N-terminal tyrosine modulation of the endocytic adaptor function of the beta-arrestins.
Marion S, Fralish GB, Laporte S, Caron MG, Barak LS
J Biol Chem. 2007
PubMed ID: 17456469
5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling.
Barthet G, Framery B, Gaven F, Pellissier L, Reiter E, Claeysen S, Bockaert J, Dumuis A
Mol Biol Cell. 2007
PubMed ID: 17377064
Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex.
Fessart D, Simaan M, Zimmerman B, Comeau J, Hamdan FF, Wiseman PW, Bouvier M, Laporte SA
J Cell Sci. 2007
PubMed ID: 17456551
Functional comparisons of visual arrestins in rod photoreceptors of transgenic mice.
Chan S, Rubin WW, Mendez A, Liu X, Song X, Hanson SM, Craft CM, Gurevich VV, Burns ME, Chen J
Invest Ophthalmol Vis Sci. 2007
PubMed ID: 17460248
Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression.
Fan H, Luttrell LM, Tempel GE, Senn JJ, Halushka PV, Cook JA
Mol Immunol. 2007
PubMed ID: 17418896
Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo.
Bryja V, Gradl D, Schambony A, Arenas E, Schulte G
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17426148
Molecular properties of rhodopsin and rod function.
Imai H, Kefalov V, Sakurai K, Chisaka O, Ueda Y, Onishi A, Morizumi T, Fu Y, Ichikawa K, Nakatani K, Honda Y, Chen J, Yau KW, Shichida Y
J Biol Chem. 2007
PubMed ID: 17194706
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G, Martin P, Rogers J, Lawlor S, McLaren S, Dricot A, Borick H, Cusick ME, Vandenhaute J, Dunham I, Hill DE, Vidal M
Genomics. 2007
PubMed ID: 17207965
Each rhodopsin molecule binds its own arrestin.
Hanson SM, Gurevich EV, Vishnivetskiy SA, Ahmed MR, Song X, Gurevich VV
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360618
Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins.
Nelson CD, Perry SJ, Regier DS, Prescott SM, Topham MK, Lefkowitz RJ
Science. 2007
PubMed ID: 17272726
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics.
Violin JD, Dewire SM, Barnes WG, Lefkowitz RJ
J Biol Chem. 2006
PubMed ID: 17008309
Stable rhodopsin/arrestin complex leads to retinal degeneration in a transgenic mouse model of autosomal dominant retinitis pigmentosa.
Chen J, Shi G, Concepcion FA, Xie G, Oprian D, Chen J
J Neurosci. 2006
PubMed ID: 17108167
Opposing effects of beta-arrestin1 and beta-arrestin2 on activation and degradation of Src induced by protease-activated receptor 1.
Kuo FT, Lu TL, Fu HW
Cell Signal. 2006
PubMed ID: 16580177
Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.
Rajagopal K, Whalen EJ, Violin JD, Stiber JA, Rosenberg PB, Premont RT, Coffman TM, Rockman HA, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17060617
Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.
Schmid EM, Ford MG, Burtey A, Praefcke GJ, Peak-Chew SY, Mills IG, Benmerah A, McMahon HT
PLoS Biol. 2006
PubMed ID: 16903783
Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets.
Hauger RL, Risbrough V, Brauns O, Dautzenberg FM
CNS Neurol Disord Drug Targets. 2006
PubMed ID: 16918397
G protein-coupled receptor kinase 2 and beta-arrestins are recruited to FSH receptor in stimulated rat primary Sertoli cells.
Marion S, Kara E, Crepieux P, Piketty V, Martinat N, Guillou F, Reiter E
J Endocrinol. 2006
PubMed ID: 16899567
Constitutive ERK1/2 activation by a chimeric neurokinin 1 receptor-beta-arrestin1 fusion protein. Probing the composition and function of the G protein-coupled receptor "signalsome".
Jafri F, El-Shewy HM, Lee MH, Kelly M, Luttrell DK, Luttrell LM
J Biol Chem. 2006
PubMed ID: 16670094
Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation.
McLaughlin NJ, Banerjee A, Kelher MR, Gamboni-Robertson F, Hamiel C, Sheppard FR, Moore EE, Silliman CC
J Immunol. 2006
PubMed ID: 16709866
Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.
Hoffert JD, Pisitkun T, Wang G, Shen RF, Knepper MA
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16641100
Cooperative regulation of extracellular signal-regulated kinase activation and cell shape change by filamin A and beta-arrestins.
Scott MG, Pierotti V, Storez H, Lindberg E, Thuret A, Muntaner O, Labbé-Jullié C, Pitcher JA, Marullo S
Mol Cell Biol. 2006
PubMed ID: 16611986
Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
Gesty-Palmer D, Chen M, Reiter E, Ahn S, Nelson CD, Wang S, Eckhardt AE, Cowan CL, Spurney RF, Luttrell LM, Lefkowitz RJ
J Biol Chem. 2006
PubMed ID: 16492667
The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor.
Innamorati G, Piccirillo R, Bagnato P, Palmisano I, Schiaffino MV
Pigment Cell Res. 2006
PubMed ID: 16524428
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
Nature. 2006
PubMed ID: 16554811
Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation.
Vaughan DJ, Millman EE, Godines V, Friedman J, Tran TM, Dai W, Knoll BJ, Clark RB, Moore RH
J Biol Chem. 2006
PubMed ID: 16407241
Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.
Edeling MA, Mishra SK, Keyel PA, Steinhauser AL, Collins BM, Roth R, Heuser JE, Owen DJ, Traub LM
Dev Cell. 2006
PubMed ID: 16516836
A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors.
Marion S, Oakley RH, Kim KM, Caron MG, Barak LS
J Biol Chem. 2006
PubMed ID: 16319069
Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.
Wang Y, Tang Y, Teng L, Wu Y, Zhao X, Pei G
Nat Immunol. 2006
PubMed ID: 16378096
Role of beta-arrestin 1 in the metastatic progression of colorectal cancer.
Buchanan FG, Gorden DL, Matta P, Shi Q, Matrisian LM, DuBois RN
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16432186
Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin.
Strissel KJ, Sokolov M, Trieu LH, Arshavsky VY
J Neurosci. 2006
PubMed ID: 16436601
Deactivation of phosphorylated and nonphosphorylated rhodopsin by arrestin splice variants.
Burns ME, Mendez A, Chen CK, Almuete A, Quillinan N, Simon MI, Baylor DA, Chen J
J Neurosci. 2006
PubMed ID: 16421323
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
Shenoy SK, Drake MT, Nelson CD, Houtz DA, Xiao K, Madabushi S, Reiter E, Premont RT, Lichtarge O, Lefkowitz RJ
J Biol Chem. 2006
PubMed ID: 16280323
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Light causes phosphorylation of nonactivated visual pigments in intact mouse rod photoreceptor cells.
Shi GW, Chen J, Concepcion F, Motamedchaboki K, Marjoram P, Langen R, Chen J
J Biol Chem. 2005
PubMed ID: 16219764
A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription.
Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, Yang R, Fan F, Chen X, Pei G, Ma L
Cell. 2005
PubMed ID: 16325578
beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae.
Radin JN, Orihuela CJ, Murti G, Guglielmo C, Murray PJ, Tuomanen EI
Infect Immun. 2005
PubMed ID: 16299272
Angiotensin II-stimulated signaling through G proteins and beta-arrestin.
Shenoy SK, Lefkowitz RJ
Sci STKE. 2005
PubMed ID: 16304060
Beta-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor.
Jones BW, Hinkle PM
J Biol Chem. 2005
PubMed ID: 16183993
A requirement for membrane cholesterol in the beta-arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors.
Urs NM, Jones KT, Salo PD, Severin JE, Trejo J, Radhakrishna H
J Cell Sci. 2005
PubMed ID: 16263766
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
Hüttenrauch F, Pollok-Kopp B, Oppermann M
J Biol Chem. 2005
PubMed ID: 16144840
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
Beta-arrestin1 and beta-arrestin2 are differentially required for phosphorylation-dependent and -independent internalization of delta-opioid receptors.
Zhang X, Wang F, Chen X, Li J, Xiang B, Zhang YQ, Li BM, Ma L
J Neurochem. 2005
PubMed ID: 16181421
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG
Cell. 2005
PubMed ID: 16051150
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.
Girnita L, Shenoy SK, Sehat B, Vasilcanu R, Girnita A, Lefkowitz RJ, Larsson O
J Biol Chem. 2005
PubMed ID: 15878855
Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein.
Mishra SK, Keyel PA, Edeling MA, Dupin AL, Owen DJ, Traub LM
J Biol Chem. 2005
PubMed ID: 15728179
beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.
Barnes WG, Reiter E, Violin JD, Ren XR, Milligan G, Lefkowitz RJ
J Biol Chem. 2005
PubMed ID: 15611106
beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform.
Szabó EZ, Numata M, Lukashova V, Iannuzzi P, Orlowski J
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15699339
Phosphorylation-independent beta-arrestin translocation and internalization of leukotriene B4 receptors.
Jala VR, Shao WH, Haribabu B
J Biol Chem. 2005
PubMed ID: 15561704
Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.
Ren XR, Reiter E, Ahn S, Kim J, Chen W, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15671180
c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during clathrin- mediated internalization.
Fessart D, Simaan M, Laporte SA
Mol Endocrinol. 2005
PubMed ID: 15498833
Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking.
Stalheim L, Ding Y, Gullapalli A, Paing MM, Wolfe BL, Morris DR, Trejo J
Mol Pharmacol. 2005
PubMed ID: 15475570
Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2.
Ge L, Shenoy SK, Lefkowitz RJ, DeFea K
J Biol Chem. 2004
PubMed ID: 15489220
Beta-arrestin-1 levels: reduced in leukocytes of patients with depression and elevated by antidepressants in rat brain.
Avissar S, Matuzany-Ruban A, Tzukert K, Schreiber G
Am J Psychiatry. 2004
PubMed ID: 15514408
Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment.
Venkatesha RT, Ahamed J, Nuesch C, Zaidi AK, Ali H
J Biol Chem. 2004
PubMed ID: 15308653
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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Genome Res. 2004
PubMed ID: 15489334
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
Usui I, Imamura T, Huang J, Satoh H, Shenoy SK, Lefkowitz RJ, Hupfeld CJ, Olefsky JM
Mol Cell Biol. 2004
PubMed ID: 15456867
beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6.
Galliera E, Jala VR, Trent JO, Bonecchi R, Signorelli P, Lefkowitz RJ, Mantovani A, Locati M, Haribabu B
J Biol Chem. 2004
PubMed ID: 15084596
beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.
Witherow DS, Garrison TR, Miller WE, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15173580
Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways.
Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B, Pei G
Mol Cell. 2004
PubMed ID: 15125834
Identification of a Ser/Thr cluster in the C-terminal domain of the human prostaglandin receptor EP4 that is essential for agonist-induced beta-arrestin1 recruitment but differs from the apparent principal phosphorylation site.
Neuschäfer-Rube F, Hermosilla R, Rehwald M, Rönnstrand L, Schülein R, Wernstedt C, Püschel GP
Biochem J. 2004
PubMed ID: 14709160
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
Hypoxia/ischemia modulates G protein-coupled receptor kinase 2 and beta-arrestin-1 levels in the neonatal rat brain.
Lombardi MS, van den Tweel E, Kavelaars A, Groenendaal F, van Bel F, Heijnen CJ
Stroke. 2004
PubMed ID: 15017017
Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.
Ahn S, Wei H, Garrison TR, Lefkowitz RJ
J Biol Chem. 2004
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Bioinformatics and cellular signaling.
Papin J, Subramaniam S
Curr Opin Biotechnol. 2004
PubMed ID: 15102471
Comparative analysis of transcriptional profiles between two apoptotic pathways of light-induced retinal degeneration.
Roca A, Shin KJ, Liu X, Simon MI, Chen J
Neuroscience. 2004
PubMed ID: 15541899
Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis.
Povsic TJ, Kohout TA, Lefkowitz RJ
J Biol Chem. 2003
PubMed ID: 14534298
The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins.
Bolger GB, McCahill A, Huston E, Cheung YF, McSorley T, Baillie GS, Houslay MD
J Biol Chem. 2003
PubMed ID: 14500724
Presence of beta-arrestin-1 immunoreactivity in the cutaneous nerve fibers of rat glabrous skin.
Komori N, Neal J, Cain SD, Logan J, Wirsig C, Miller KE
Brain Res. 2003
PubMed ID: 14519533
Multiple steps of phosphorylation of activated rhodopsin can account for the reproducibility of vertebrate rod single-photon responses.
Hamer RD, Nicholas SC, Tranchina D, Liebman PA, Lamb TD
J Gen Physiol. 2003
PubMed ID: 12975449
The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins.
Schmidlin F, Roosterman D, Bunnett NW
Am J Physiol Cell Physiol. 2003
PubMed ID: 12958028
A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis.
Ge L, Ly Y, Hollenberg M, DeFea K
J Biol Chem. 2003
PubMed ID: 12821670
Light-dependent translocation of arrestin in the absence of rhodopsin phosphorylation and transducin signaling.
Mendez A, Lem J, Simon M, Chen J
J Neurosci. 2003
PubMed ID: 12716919
Role of G protein-coupled receptor kinase 4 and beta-arrestin 1 in agonist-stimulated metabotropic glutamate receptor 1 internalization and activation of mitogen-activated protein kinases.
Iacovelli L, Salvatore L, Capobianco L, Picascia A, Barletta E, Storto M, Mariggiò S, Sallese M, Porcellini A, Nicoletti F, De Blasi A
J Biol Chem. 2003
PubMed ID: 12519791
Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus.
Wang P, Wu Y, Ge X, Ma L, Pei G
J Biol Chem. 2003
PubMed ID: 12538596
Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference.
Ahn S, Nelson CD, Garrison TR, Miller WE, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12582207
Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway.
Braun L, Christophe T, Boulay F
J Biol Chem. 2003
PubMed ID: 12464600
Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes.
Hupfeld CJ, Dalle S, Olefsky JM
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12509508
Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.
Hanyaloglu AC, Seeber RM, Kohout TA, Lefkowitz RJ, Eidne KA
J Biol Chem. 2002
PubMed ID: 12393857
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
Perry SJ, Baillie GS, Kohout TA, McPhee I, Magiera MM, Ang KL, Miller WE, McLean AJ, Conti M, Houslay MD, Lefkowitz RJ
Science. 2002
PubMed ID: 12399592
The COOH-terminus of parathyroid hormone-related protein (PTHrP) interacts with beta-arrestin 1B.
Conlan LA, Martin TJ, Gillespie MT
FEBS Lett. 2002
PubMed ID: 12220636
Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1.
Dalle S, Imamura T, Rose DW, Worrall DS, Ugi S, Hupfeld CJ, Olefsky JM
Mol Cell Biol. 2002
PubMed ID: 12167719
Beta-arrestin binding to CC chemokine receptor 5 requires multiple C-terminal receptor phosphorylation sites and involves a conserved Asp-Arg-Tyr sequence motif.
Huttenrauch F, Nitzki A, Lin FT, Höning S, Oppermann M
J Biol Chem. 2002
PubMed ID: 12065593
Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization.
Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SS
Nat Cell Biol. 2002
PubMed ID: 12105416
Interferon beta-1a counteracts effects of activation on the expression of G-protein-coupled receptor kinases 2 and 3, beta-arrestin-1, and regulators of G-protein signalling 2 and 16 in human mononuclear leukocytes.
Giorelli M, Livrea P, Defazio G, Iacovelli L, Capobianco L, Picascia A, Sallese M, Martino D, Aniello MS, Trojano M, De Blasi A
Cell Signal. 2002
PubMed ID: 12020767
alpha-Thrombin induces rapid and sustained Akt phosphorylation by beta-arrestin1-dependent and -independent mechanisms, and only the sustained Akt phosphorylation is essential for G1 phase progression.
Goel R, Phillips-Mason PJ, Raben DM, Baldassare JJ
J Biol Chem. 2002
PubMed ID: 11901145
Aspartic acid 564 in the third cytoplasmic loop of the luteinizing hormone/choriogonadotropin receptor is crucial for phosphorylation-independent interaction with arrestin2.
Mukherjee S, Gurevich VV, Preninger A, Hamm HE, Bader MF, Fazleabas AT, Birnbaumer L, Hunzicker-Dunn M
J Biol Chem. 2002
PubMed ID: 11867621
beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptin.
Laporte SA, Miller WE, Kim KM, Caron MG
J Biol Chem. 2002
PubMed ID: 11777907
beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation.
Tohgo A, Pierce KL, Choy EW, Lefkowitz RJ, Luttrell LM
J Biol Chem. 2002
PubMed ID: 11777902
Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association.
Vilardaga JP, Krasel C, Chauvin S, Bambino T, Lohse MJ, Nissenson RA
J Biol Chem. 2002
PubMed ID: 11726668
Functionally rodless mice: transgenic models for the investigation of cone function in retinal disease and therapy.
Lyubarsky AL, Lem J, Chen J, Falsini B, Iannaccone A, Pugh EN
Vision Res. 2002
PubMed ID: 11853756
beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.
Chen W, Hu LA, Semenov MV, Yanagawa S, Kikuchi A, Lefkowitz RJ, Miller WE
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11742073
Myocardial distribution and regulation of GRK and beta-arrestin isoforms in congestive heart failure in rats.
Vinge LE, Øie E, Andersson Y, Grøgaard HK, Andersen G, Attramadal H
Am J Physiol Heart Circ Physiol. 2001
PubMed ID: 11709416
beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport.
Imamura T, Huang J, Dalle S, Ugi S, Usui I, Luttrell LM, Miller WE, Lefkowitz RJ, Olefsky JM
J Biol Chem. 2001
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Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.
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Science. 2001
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beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis.
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J Biol Chem. 2001
PubMed ID: 11533043
Gene expression profiles of light-induced apoptosis in arrestin/rhodopsin kinase-deficient mouse retinas.
Choi S, Hao W, Chen CK, Simon MI
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11687607
GGAs: roles of the different domains and comparison with AP-1 and clathrin.
Hirst J, Lindsay MR, Robinson MS
Mol Biol Cell. 2001
PubMed ID: 11694590
Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization.
Qian H, Pipolo L, Thomas WG
Mol Endocrinol. 2001
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Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3.
Miller WE, McDonald PH, Cai SF, Field ME, Davis RJ, Lefkowitz RJ
J Biol Chem. 2001
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Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development.
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Hum Mol Genet. 2001
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Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer.
Kroeger KM, Hanyaloglu AC, Seeber RM, Miles LE, Eidne KA
J Biol Chem. 2001
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Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor.
Cen B, Yu Q, Guo J, Wu Y, Ling K, Cheng Z, Ma L, Pei G
J Neurochem. 2001
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beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking.
Kohout TA, Lin FS, Perry SJ, Conner DA, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11171997
Functional annotation of a full-length mouse cDNA collection.
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Nature. 2001
PubMed ID: 11217851
Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor internalization.
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Biochemistry. 2001
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Three ways to make a vesicle.
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Nat Rev Mol Cell Biol. 2000
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
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Genome Res. 2000
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
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The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex.
DeFea KA, Vaughn ZD, O'Bryan EM, Nishijima D, Déry O, Bunnett NW
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10995467
Interaction with beta-arrestin determines the difference in internalization behavor between beta1- and beta2-adrenergic receptors.
Shiina T, Kawasaki A, Nagao T, Kurose H
J Biol Chem. 2000
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Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI.
Barlic J, Andrews JD, Kelvin AA, Bosinger SE, DeVries ME, Xu L, Dobransky T, Feldman RD, Ferguson SS, Kelvin DJ
Nat Immunol. 2000
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Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence.
Bennett TA, Maestas DC, Prossnitz ER
J Biol Chem. 2000
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The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits.
Laporte SA, Oakley RH, Holt JA, Barak LS, Caron MG
J Biol Chem. 2000
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Regulation and intracellular trafficking pathways of the endothelin receptors.
Bremnes T, Paasche JD, Mehlum A, Sandberg C, Bremnes B, Attramadal H
J Biol Chem. 2000
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Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors.
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J Biol Chem. 2000
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beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis.
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J Biol Chem. 2000
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beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2.
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J Cell Biol. 2000
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Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses.
Lyubarsky AL, Chen C, Simon MI, Pugh EN
J Neurosci. 2000
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beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4.
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J Biol Chem. 2000
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Secretory protein trafficking and organelle dynamics in living cells.
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Annu Rev Cell Dev Biol. 2000
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Increased susceptibility to light damage in an arrestin knockout mouse model of Oguchi disease (stationary night blindness)
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Invest Ophthalmol Vis Sci. 1999
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Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization.
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J Biol Chem. 1999
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Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin.
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Biochemistry. 1999
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beta-arrestins regulate interleukin-8-induced CXCR1 internalization.
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J Biol Chem. 1999
PubMed ID: 10347185
Substance P-induced trafficking of beta-arrestins. The role of beta-arrestins in endocytosis of the neurokinin-1 receptor.
McConalogue K, Déry O, Lovett M, Wong H, Walsh JH, Grady EF, Bunnett NW
J Biol Chem. 1999
PubMed ID: 10347182
Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases.
Lin FT, Miller WE, Luttrell LM, Lefkowitz RJ
J Biol Chem. 1999
PubMed ID: 10347142
Regulation of muscarinic acetylcholine receptor sequestration and function by beta-arrestin.
Vögler O, Nolte B, Voss M, Schmidt M, Jakobs KH, van Koppen CJ
J Biol Chem. 1999
PubMed ID: 10212203
Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation.
McDonald PH, Cote NL, Lin FT, Premont RT, Pitcher JA, Lefkowitz RJ
J Biol Chem. 1999
PubMed ID: 10196135
The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.
Laporte SA, Oakley RH, Zhang J, Holt JA, Ferguson SS, Caron MG, Barak LS
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10097102
Targeted construction of phosphorylation-independent beta-arrestin mutants with constitutive activity in cells.
Kovoor A, Celver J, Abdryashitov RI, Chavkin C, Gurevich VV
J Biol Chem. 1999
PubMed ID: 10066734
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ
Science. 1999
PubMed ID: 9924018
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor.
Lin FT, Daaka Y, Lefkowitz RJ
J Biol Chem. 1998
PubMed ID: 9822622
Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker.
ter Haar E, Musacchio A, Harrison SC, Kirchhausen T
Cell. 1998
PubMed ID: 9827808
G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization.
Lefkowitz RJ
J Biol Chem. 1998
PubMed ID: 9668034
Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2.
Aragay AM, Mellado M, Frade JM, Martin AM, Jimenez-Sainz MC, Martinez-A C, Mayor F
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9501202
Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.
Lin FT, Krueger KM, Kendall HE, Daaka Y, Fredericks ZL, Pitcher JA, Lefkowitz RJ
J Biol Chem. 1997
PubMed ID: 9388255
beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation.
Conner DA, Mathier MA, Mortensen RM, Christe M, Vatner SF, Seidman CE, Seidman JG
Circ Res. 1997
PubMed ID: 9400383
Prolonged photoresponses in transgenic mouse rods lacking arrestin.
Xu J, Dodd RL, Makino CL, Simon MI, Baylor DA, Chen J
Nature. 1997
PubMed ID: 9333241
Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain.
Goodman OB, Krupnick JG, Gurevich VV, Benovic JL, Keen JH
J Biol Chem. 1997
PubMed ID: 9169477
Partial structure, chromosome localization, and expression of the mouse Icln gene.
Wickman K, Seldin MF, James MR, Gendler SJ, Clapham DE
Genomics. 1997
PubMed ID: 9073507
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia.
Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH
Nat Genet. 1997
PubMed ID: 9054939
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
GRK2 and beta-arrestin 1 as negative regulators of thyrotropin receptor-stimulated response.
Iacovelli L, Franchetti R, Masini M, De Blasi A
Mol Endocrinol. 1996
PubMed ID: 8885248
Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.
Ferguson SS, Downey WE, Colapietro AM, Barak LS, Ménard L, Caron MG
Science. 1996
PubMed ID: 8553074
Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively.
Kingsmore SF, Peppel K, Suh D, Caron MG, Lefkowitz RJ, Seldin MF
Mamm Genome. 1995
PubMed ID: 7613043
Assignment of the beta-arrestin 1 gene (ARRB1) to human chromosome 11q13.
Calabrese G, Sallese M, Stornaiuolo A, Morizio E, Palka G, De Blasi A
Genomics. 1994
PubMed ID: 7896272
Light-dependent regulation of the transcriptional activity of the mammalian gene for arrestin.
McGinnis JF, Austin BJ, Stepanik PL, Lerious V
J Neurosci Res. 1994
PubMed ID: 7932878
The proximal promoter of the mouse arrestin gene directs gene expression in photoreceptor cells and contains an evolutionarily conserved retinal factor-binding site.
Kikuchi T, Raju K, Breitman ML, Shinohara T
Mol Cell Biol. 1993
PubMed ID: 8321239
Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing.
Parruti G, Peracchia F, Sallese M, Ambrosini G, Masini M, Rotilio D, De Blasi A
J Biol Chem. 1993
PubMed ID: 8486659
A family of retinal S-antigens (arrestins) and their genes: comparative analysis of human, mouse, rat, bovine and Drosophila.
Shinohara T, Kikuchi T, Tsuda M, Yamaki K
Comp Biochem Physiol B. 1992
PubMed ID: 1458825
Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.
Attramadal H, Arriza JL, Aoki C, Dawson TM, Codina J, Kwatra MM, Snyder SH, Caron MG, Lefkowitz RJ
J Biol Chem. 1992
PubMed ID: 1517224
beta-Arrestin: a protein that regulates beta-adrenergic receptor function.
Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ
Science. 1990
PubMed ID: 2163110

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	408	109689	25387
EnsEMBL Gene(s)	ENSG00000137486	ENSMUSG00000018909	ENSRNOG00000030404
Unigene	Hs.503284	Mm.260193	Rn.34876
Homologene	ARRB1	Arrb1	Arrb1
OMIM	107940	N/A	N/A
GeneCards	ARRB1	N/A	N/A
Beta Cell Genomics	DT.85104858 DT.95077272 DT.97839794	DT.94365337 DT.97407462	N/A
Reactome	P49407	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	408	109689	25387

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
ARRB1	RANBP9	IntAct	empirical	17620599
ARRB1	DNAJB6	MINT, IntAct	empirical	15102471
ARRB1	ARPC5	IntAct	empirical	17620599
ARRB1	G3BP1	IntAct	empirical	17620599
ARRB1	ALYREF	IntAct	empirical	17620599
ARRB1	DHRS2	IntAct	empirical	17620599
ARRB1	STUB1	BioGRID	empirical	19306926
ARRB1	RTN3	MINT, IntAct	empirical	15102471
ARRB1	MYL12B	IntAct	empirical	17620599
ARRB1	PRMT5	IntAct	empirical	17620599
ARRB1	HAX1	MINT, IntAct	empirical	15102471
ARRB1	IGF2BP2	IntAct	empirical	17620599
ARRB1	CFL1	IntAct	empirical	17620599 17500066
ARRB1	NEK6	IntAct	empirical	21988832
ARRB1	CD3EAP	IntAct	empirical	17620599
ARRB1	SPIN1	IntAct	empirical	17620599
ARRB1	CKAP4	IntAct	empirical	17620599
ARRB1	YWHAQ	IntAct	empirical	17620599
ARRB1	SF3B2	IntAct	empirical	17620599
ARRB1	KIF2C	IntAct	empirical	17620599
ARRB1	CHD1	BioGRID	empirical	17353931
ARRB1	KIF3A	IntAct	empirical	17620599
ARRB1	STK38	IntAct	empirical	17620599
ARRB1	CLTA	IntAct	empirical	17620599
ARRB1	CLTC	HPRD, IntAct	empirical	9169477 17620599
ARRB1	CCR5	HPRD, BioGRID	empirical	12065593
ARRB1	CNGA3	IntAct	empirical	17620599
ARRB1	ADH6	IntAct	empirical	21988832
ARRB1	CMBL	IntAct, BioGRID	empirical	17353931
ARRB1	STXBP5	IntAct	empirical	17620599
ARRB1	CPA1	IntAct	empirical	17620599
ARRB1	CPNE8	IntAct	empirical	17620599
ARRB1	CSK	HPRD, BioGRID	empirical	10753943
ARRB1	CSN2	IntAct	empirical	17620599
ARRB1	CSNK2A1	IntAct, BioGRID	empirical	17353931
ARRB1	ADRB1	HPRD, BioGRID	empirical	10862778
ARRB1	ADRB2	HPRD	empirical	16407241
ARRB1	ADRBK1	HPRD	empirical	8885248
ARRB1	DGKG	IntAct	empirical	17620599
ARRB1	DGKH	IntAct	empirical	17620599
ARRB1	AP2B1	HPRD	empirical	11777907
ARRB1	DKC1	IntAct	empirical	17620599
ARRB1	DMD	IntAct	empirical	17620599
ARRB1	DNM1	IntAct	empirical	17620599
ARRB1	AGTR1	HPRD, MINT	empirical	11579203 17498700
ARRB1	DVL1	HPRD	empirical	11742073
ARRB1	DVL2	HPRD, BioGRID	empirical	11742073
ARRB1	EEF1A2	IntAct	empirical	17620599
ARRB1	EIF4B	IntAct	empirical	17620599
ARRB1	CTTN	IntAct	empirical	17620599
ARRB1	TUBB	IntAct	empirical	17620599
ARRB1	AKT1	IntAct	empirical	16051150
ARRB1	F2R	Reactome	predicted	16580177
ARRB1	FASN	IntAct	empirical	17620599
ARRB1	HNRNPA3	IntAct	empirical	17620599
ARRB1	FGR	HPRD	empirical	10973280
ARRB1	STK38L	IntAct	empirical	17620599
ARRB1	USP33	BioGRID	empirical	19363159
ARRB1	ZBTB43	HPRD, MINT, IntAct, BioGRID	empirical	16189514
ARRB1	FLNA	HPRD, IntAct	empirical	16611986 17620599
ARRB1	MPRIP	IntAct	empirical	17620599
ARRB1	RTF1	IntAct, BioGRID	empirical	17353931
ARRB1	BOP1	IntAct, BioGRID	empirical	17353931
ARRB1	USP24	IntAct	empirical	17620599
ARRB1	PES1	IntAct, BioGRID	empirical	17353931
ARRB1	SRRM2	IntAct	empirical	17620599
ARRB1	POLR1A	IntAct	empirical	17620599
ARRB1	RAB11FIP5	IntAct	empirical	17620599
ARRB1	KIF26A	IntAct	empirical	17620599
ARRB1	AMPD2	Sanger Interaction Map	predicted	15345047
ARRB1	GNMT	HPRD, MINT, IntAct, BioGRID	empirical	16189514 21988832
ARRB1	RPL7L1	IntAct, BioGRID	empirical	17353931
ARRB1	GSK3B	BioGRID	empirical	10347142
ARRB1	GSN	IntAct	empirical	17620599
ARRB1	TMOD3	IntAct	empirical	17620599
ARRB1	HIST1H1C	IntAct	empirical	17620599
ARRB1	H2AFX	IntAct	empirical	17620599
ARRB1	ANXA2	IntAct	empirical	17620599
ARRB1	HCK	HPRD	empirical	10973280
ARRB1	HDLBP	IntAct	empirical	17620599
ARRB1	ACACA	IntAct	empirical	17620599
ARRB1	HIST2H2AB	IntAct	empirical	17620599
ARRB1	HNRNPA1	MINT, IntAct	empirical	17620599 15102471
ARRB1	HNRNPH1	IntAct	empirical	17620599
ARRB1	HNRNPK	IntAct	empirical	17620599
ARRB1	HNRNPU	IntAct	empirical	17620599
ARRB1	HSPA5	IntAct	empirical	17620599
ARRB1	HSPA7	IntAct	empirical	17620599
ARRB1	HSPA8	IntAct	empirical	17620599
ARRB1	HSPA9	IntAct	empirical	17620599
ARRB1	HSP90AA1	IntAct	empirical	17620599
ARRB1	APLP1	IntAct	empirical	17620599
ARRB1	ACTBL2	IntAct	empirical	17620599
ARRB1	IGF1R	BioGRID	empirical	12167719
ARRB1	CXCR2	HPRD, BioGRID	empirical	11170396
ARRB1	JAK1	BioGRID	empirical	17353931
ARRB1	JUN	IntAct, BioGRID	empirical	20936779
ARRB1	KHK	IntAct, BioGRID	empirical	17353931
ARRB1	ARF6	HPRD, BioGRID	empirical	11533043 11867621
ARRB1	KPNA3	IntAct, BioGRID	empirical	17353931
ARRB1	KTN1	IntAct	empirical	17620599
ARRB1	LIMK1	IntAct	empirical	17500066
ARRB1	LRP4	IntAct	empirical	17620599
ARRB1	ARR3	IntAct, BioGRID	empirical	17353931 17620599
ARRB1	ARRB1	IntAct	empirical	17620599
ARRB1	ARRB2	IntAct, BioGRID	empirical	17353931 17620599
ARRB1	MAP1B	IntAct	empirical	17620599
ARRB1	MATN2	MINT, IntAct	empirical	15102471
ARRB1	MDM2	MINT, IntAct, BioGRID	empirical	19879840 15102471 12538596 18544533 11588219
ARRB1	MAP3K1	IntAct	empirical	17620599
ARRB1	MAP3K5	BioGRID	empirical	19306926
ARRB1	POTEKP	IntAct	empirical	17620599
ARRB1	MT1A	MINT	empirical	16778767
ARRB1	MYH1	IntAct	empirical	17620599
ARRB1	MYH9	IntAct	empirical	17620599
ARRB1	MYL6	IntAct	empirical	17620599
ARRB1	MYO1C	IntAct	empirical	17620599
ARRB1	HNRNPM	IntAct	empirical	17620599
ARRB1	NCL	IntAct	empirical	17620599
ARRB1	NDUFS1	IntAct	empirical	17620599
ARRB1	NFE2L2	MINT, IntAct	empirical	15102471
ARRB1	NFKBIA	HPRD, IntAct	empirical	15125834 15173580 19879840
ARRB1	NPM1	IntAct	empirical	17620599
ARRB1	YBX1	IntAct	empirical	17620599
ARRB1	NSF	HPRD, BioGRID	empirical	10196135
ARRB1	ATP5A1	IntAct	empirical	17620599
ARRB1	OPRD1	HPRD, BioGRID	empirical	11259507
ARRB1	P4HB	IntAct	empirical	17620599
ARRB1	ATP5B	IntAct	empirical	17620599
ARRB1	PARK2	BioGRID	empirical	21466165
ARRB1	KCTD3	IntAct	empirical	17620599
ARRB1	PLA1A	IntAct	empirical	17620599
ARRB1	PDE4D	BioGRID	empirical	19372219
ARRB1	LIMA1	IntAct	empirical	17620599
ARRB1	PFKFB3	IntAct	empirical	17620599
ARRB1	PIK3C2A	IntAct	empirical	17620599
ARRB1	PIK3R2	IntAct	empirical	17620599 21988832
ARRB1	PKM2	IntAct	empirical	17620599
ARRB1	LRP1B	IntAct	empirical	17620599
ARRB1	POLR2E	IntAct	empirical	17620599
ARRB1	ATR	IntAct	empirical	17620599
ARRB1	PPIA	IntAct	empirical	17620599
ARRB1	PPM1A	IntAct	empirical	17620599
ARRB1	PPM1B	IntAct	empirical	17620599
ARRB1	C9orf68	Sanger Interaction Map	predicted	15345047
ARRB1	NOP10	IntAct	empirical	17620599
ARRB1	DNAH3	IntAct	empirical	17620599
ARRB1	DDX27	IntAct, BioGRID	empirical	17353931
ARRB1	SCYL2	IntAct	empirical	17620599
ARRB1	MAPK1	HPRD, BioGRID	empirical	10347142 9388255
ARRB1	MAPK3	HPRD, BioGRID	empirical	10347142 9388255
ARRB1	MAPK9	IntAct	empirical	21988832
ARRB1	MAPK10	IntAct, BioGRID	empirical	19879840 11356842
ARRB1	PDXP	IntAct	empirical	17500066
ARRB1	BAG1	IntAct	empirical	21988832
ARRB1	PTHLH	HPRD, BioGRID	empirical	12220636
ARRB1	PTH1R	HPRD	empirical	12220636
ARRB1	ACTA1	IntAct	empirical	17620599
ARRB1	RAB1A	IntAct	empirical	17620599
ARRB1	RALGDS	HPRD, BioGRID	empirical	12105416
ARRB1	TRPV4	BioGRID	empirical	20650893
ARRB1	RGS3	IntAct	empirical	17620599
ARRB1	ACTB	IntAct	empirical	17620599
ARRB1	BACH2	IntAct	empirical	17620599
ARRB1	ROCK1	IntAct	empirical	17620599
ARRB1	RPL3	IntAct	empirical	17620599
ARRB1	RPL6	IntAct	empirical	17620599
ARRB1	RPL7A	IntAct	empirical	17620599
ARRB1	RPL15	IntAct	empirical	21988832
ARRB1	RPL22	IntAct	empirical	17620599
ARRB1	RPS2	IntAct	empirical	17620599
ARRB1	RPS3A	IntAct	empirical	17620599
ARRB1	RPS8	IntAct	empirical	17620599
ARRB1	RPS17	IntAct	empirical	17620599
ARRB1	RPS27A	IntAct	empirical	17620599
ARRB1	S100A9	IntAct	empirical	17620599
ARRB1	SAG	IntAct	empirical	17620599
ARRB1	CCL14	IntAct	empirical	17353931
ARRB1	POLR1E	IntAct	empirical	17620599
ARRB1	SLC9A1	BioGRID	empirical	20855896
ARRB1	SLC9A5	HPRD	empirical	15699339
ARRB1	BMPR2	MINT, IntAct	empirical	15102471
ARRB1	SNRPD1	IntAct	empirical	17620599
ARRB1	SON	MINT, IntAct	empirical	15102471
ARRB1	SPTAN1	IntAct	empirical	17620599
ARRB1	SREBF2	IntAct, BioGRID	empirical	20936779
ARRB1	TCOF1	IntAct, BioGRID	empirical	17353931 17620599
ARRB1	BTK	IntAct	empirical	21988832
ARRB1	TMPO	IntAct	empirical	17620599
ARRB1	TOP2A	MINT, IntAct	empirical	15102471
ARRB1	TPM4	IntAct	empirical	17620599
ARRB1	TRAF6	IntAct	empirical	19879840
ARRB1	TRHR	HPRD	empirical	12393857 11278883
ARRB1	TTN	IntAct	empirical	17620599
ARRB1	TUBA4A	IntAct	empirical	17620599
ARRB1	C5AR1	HPRD	empirical	12464600
ARRB1	TUBB2A	IntAct	empirical	17620599
ARRB1	UBA52	IntAct	empirical	17620599
ARRB1	UBB	IntAct	empirical	17620599
ARRB1	UBC	IntAct, BioGRID	empirical	17620599 19372219
ARRB1	VIM	MINT, IntAct	empirical	17620599 15102471
ARRB1	XRCC5	IntAct	empirical	17620599
ARRB1	YES1	IntAct	empirical	17620599
ARRB1	YY1	IntAct	empirical	19879840
ARRB1	YWHAB	IntAct	empirical	17620599
ARRB1	YWHAE	IntAct	empirical	17620599
ARRB1	YWHAG	IntAct	empirical	17620599
ARRB1	YWHAH	IntAct	empirical	17620599
ARRB1	YWHAZ	IntAct	empirical	17620599
ARRB1	ZYX	IntAct	empirical	17620599
ARRB1	WDR77	IntAct	empirical	17620599
ARRB1	CALD1	IntAct	empirical	17620599
ARRB1	STAM	BioGRID	empirical	20505072
ARRB1	RBM10	IntAct	empirical	17620599
ARRB1	NAA10	IntAct, BioGRID	empirical	20360068
ARRB1	HIST1H2BO	IntAct	empirical	17620599
ARRB1	ITCH	BioGRID	empirical	18544533
ARRB1	TAGLN2	Sanger Interaction Map	predicted	15345047
ARRB1	GNPAT	MINT, IntAct	empirical	15102471
ARRB1	DPY30	IntAct	empirical	17620599
ARRB1	HDGFRP2	IntAct, BioGRID	empirical	17353931 17620599
ARRB1	TUBA1C	IntAct	empirical	17620599
ARRB1	DGKZ	IntAct	empirical	17620599
ARRB1	DGKE	IntAct	empirical	17620599
ARRB1	AP3B1	IntAct, BioGRID	empirical	17353931
ARRB1	PTCH2	IntAct	empirical	17620599
ARRB1	EIF3I	IntAct	empirical	17620599
ARRB1	CD164	MINT, IntAct	empirical	15102471
ARRB1	PRPF4B	IntAct	empirical	17620599
ARRB1	AP3D1	IntAct	empirical	17620599
ARRB1	H1FX	IntAct	empirical	17620599
ARRB1	INA	IntAct	empirical	17620599
ARRB1	HGS	BioGRID	empirical	20505072
ARRB1	NOLC1	IntAct, BioGRID	empirical	17353931 17620599
ARRB1	CYTH2	HPRD, BioGRID	empirical	11533043
ARRB1	ZRANB2	IntAct, BioGRID	empirical	17353931 17620599
ARRB1	POLR1C	IntAct	empirical	17620599
ARRB1	SDC3	IntAct	empirical	17620599
ARRB1	ARHGAP32	IntAct	empirical	17620599
ARRB1	BCLAF1	IntAct	empirical	17620599
ARRB1	THRAP3	IntAct	empirical	17620599
ARRB1	CDC42	IntAct, BioGRID	empirical	20936779