LIMK1

Summary Top Help

Gene Description:

LIM-domain containing, protein kinase; LIM domain kinase 1

Synonyms:

LIMK, Limk1, LIMK-1, LIMK1

Orthologs:

Human LIMK1 (protein-coding), Mouse Limk1 (protein-coding), Rat Limk1 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 1

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm30	Rat	chr12:8901318..29369703	20.47	318

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr7:73497263..73536855 (39.59 kb) View in Genome Browser

(Mouse) NCBIM37 - chr5:135131909..135164460 (32.55 kb) View in Genome Browser

(Rat) RGSC3.4 - chr12:23091784..23125718 (33.93 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for LIMK1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for LIMK1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 3

Biocarta: 4

Reactome: 5

NCI-Nature Pathway Interaction Database: 5

Gene Ontology: 22

Publications from PubMed Top Help

Publications: 152

LIM kinase has a dual role in regulating lamellipodium extension by decelerating the rate of actin retrograde flow and the rate of actin polymerization.
Ohashi K, Fujiwara S, Watanabe T, Kondo H, Kiuchi T, Sato M, Mizuno K
J Biol Chem. 2011
PubMed ID: 21868383
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
J Biol Chem. 2011
PubMed ID: 21321123
LIM kinase mediates estrogen action on the actin depolymerization factor Cofilin.
Yuen GS, McEwen BS, Akama KT
Brain Res. 2011
PubMed ID: 20696146
Impact of LIMK1, MMP2 and TNF-α variations for intracranial aneurysm in Japanese population.
Low SK, Zembutsu H, Takahashi A, Kamatani N, Cha PC, Hosono N, Kubo M, Matsuda K, Nakamura Y
J Hum Genet. 2011
PubMed ID: 21228795
Tissue specific characterisation of Lim-kinase 1 expression during mouse embryogenesis.
Lindström NO, Neves C, McIntosh R, Miedzybrodzka Z, Vargesson N, Collinson JM
Gene Expr Patterns. 2011
PubMed ID: 21167960
GluA2 (GluR2) regulates metabotropic glutamate receptor-dependent long-term depression through N-cadherin-dependent and cofilin-mediated actin reorganization.
Zhou Z, Hu J, Passafaro M, Xie W, Jia Z
J Neurosci. 2011
PubMed ID: 21248105
LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators.
Manetti F
Med Res Rev. 2011
PubMed ID: 21241000
LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes.
Ishaq M, Lin BR, Bosche M, Zheng X, Yang J, Huang D, Lempicki RA, Natarajan V
BMC Mol Biol. 2011
PubMed ID: 21923909
Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression.
McConnell BV, Koto K, Gutierrez-Hartmann A
Mol Cancer. 2011
PubMed ID: 21682918
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells.
Tapia T, Ottman R, Chakrabarti R
Mol Cancer. 2011
PubMed ID: 21219645
Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.
Li D, Hallett MA, Zhu W, Rubart M, Liu Y, Yang Z, Chen H, Haneline LS, Chan RJ, Schwartz RJ, Field LJ, Atkinson SJ, Shou W
Development. 2011
PubMed ID: 21177343
The bone morphogenetic protein roof plate chemorepellent regulates the rate of commissural axonal growth.
Phan KD, Hazen VM, Frendo M, Jia Z, Butler SJ
J Neurosci. 2010
PubMed ID: 21084599
A study of the expression and interaction of Destrin, cofilin, and LIMK in Debakey I type thoracic aortic dissection tissue.
Tian L, Liao MF, Zhang L, Lu QS, Jing ZP
Scand J Clin Lab Invest. 2010
PubMed ID: 20873970
Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability.
Firulli BA, McConville DP, Byers JS, Vincentz JW, Barnes RM, Firulli AB
Dev Dyn. 2010
PubMed ID: 20737509
Common genetic polymorphisms in Moyamoya and atherosclerotic disease in Europeans.
Roder C, Peters V, Kasuya H, Nishizawa T, Takehara Y, Berg D, Schulte C, Khan N, Tatagiba M, Krischek B
Childs Nerv Syst. 2010
PubMed ID: 20694560
Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development.
Mokalled MH, Johnson A, Kim Y, Oh J, Olson EN
Development. 2010
PubMed ID: 20534669
Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation.
Borensztajn K, Peppelenbosch MP, Spek CA
Thromb Res. 2010
PubMed ID: 20347121
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Dev Cell. 2010
PubMed ID: 20412781
Expression profiling of G2/M phase regulatory proteins in normal, premalignant and malignant uterine cervix and their correlation with survival of patients.
Chhavi, Saxena M, Singh S, Negi MP, Srivastava AK, Trivedi R, Singh U, Pant MC, Bhatt ML
J Cancer Res Ther. 2010
PubMed ID: 20622363
Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications.
Jiang XS, Wassif CA, Backlund PS, Song L, Holtzclaw LA, Li Z, Yergey AL, Porter FD
Hum Mol Genet. 2010
PubMed ID: 20067919
Regulation of vascular endothelial growth factor-induced endothelial cell migration by LIM kinase 1-mediated phosphorylation of annexin 1.
Côté MC, Lavoie JR, Houle F, Poirier A, Rousseau S, Huot J
J Biol Chem. 2010
PubMed ID: 20061392
LIM-kinase is critical for the mesenchymal-to-amoeboid cell morphological transition in 3D matrices.
Mishima T, Naotsuka M, Horita Y, Sato M, Ohashi K, Mizuno K
Biochem Biophys Res Commun. 2010
PubMed ID: 20100465
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC
PLoS One. 2010
PubMed ID: 20634891
DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1.
Li X, Ke Q, Li Y, Liu F, Zhu G, Li F
Int J Biochem Cell Biol. 2010
PubMed ID: 19778628
LIMK1 and LIMK2 are important for metastatic behavior and tumor cell-induced angiogenesis of pancreatic cancer cells.
Vlecken DH, Bagowski CP
Zebrafish. 2009
PubMed ID: 20047470
Autotaxin/lysophospholipase D-mediated lysophosphatidic acid signaling is required to form distinctive large lysosomes in the visceral endoderm cells of the mouse yolk sac.
Koike S, Keino-Masu K, Ohto T, Sugiyama F, Takahashi S, Masu M
J Biol Chem. 2009
PubMed ID: 19808661
The Cdk inhibitor p57(Kip2) controls LIM-kinase 1 activity and regulates actin cytoskeleton dynamics.
Vlachos P, Joseph B
Oncogene. 2009
PubMed ID: 19734939
Ca2+/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite outgrowth.
Takemura M, Mishima T, Wang Y, Kasahara J, Fukunaga K, Ohashi K, Mizuno K
J Biol Chem. 2009
PubMed ID: 19696021
LIM kinase 1 promotes endothelial barrier disruption and neutrophil infiltration in mouse lungs.
Gorovoy M, Han J, Pan H, Welch E, Neamu R, Jia Z, Predescu D, Vogel S, Minshall RD, Ye RD, Malik AB, Voyno-Yasenetskaya T
Circ Res. 2009
PubMed ID: 19679840
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF).
Yoshimura K, Kitagawa H, Fujiki R, Tanabe M, Takezawa S, Takada I, Yamaoka I, Yonezawa M, Kondo T, Furutani Y, Yagi H, Yoshinaga S, Masuda T, Fukuda T, Yamamoto Y, Ebihara K, Li DY, Matsuoka R, Takeuchi JK, Matsumoto T, Kato S
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19470456
Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1.
Nadella KS, Saji M, Jacob NK, Pavel E, Ringel MD, Kirschner LS
EMBO Rep. 2009
PubMed ID: 19424295
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome.
Yoshida T, Kato K, Fujimaki T, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Tanaka M, Nozawa Y, Yamada Y
Genomics. 2009
PubMed ID: 19056482
Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3.
Chai X, Förster E, Zhao S, Bock HH, Frotscher M
J Neurosci. 2009
PubMed ID: 19129405
Inefficient search of large-scale space in Williams syndrome: further insights on the role of LIMK1 deletion in deficits of spatial cognition.
Smith AD, Gilchrist ID, Hood B, Tassabehji M, Karmiloff-Smith A
Perception. 2009
PubMed ID: 19662944
Estrous cycle regulates activation of hippocampal Akt, LIM kinase, and neurotrophin receptors in C57BL/6 mice.
Spencer JL, Waters EM, Milner TA, McEwen BS
Neuroscience. 2008
PubMed ID: 18601981
Genes, plasticity and mental retardation.
Vaillend C, Poirier R, Laroche S
Behav Brain Res. 2008
PubMed ID: 18329113
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals.
Yamada Y, Metoki N, Yoshida H, Satoh K, Kato K, Hibino T, Yokoi K, Watanabe S, Ichihara S, Aoyagi Y, Yasunaga A, Park H, Tanaka M, Nozawa Y
Stroke. 2008
PubMed ID: 18566305
A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF.
Ahmed T, Shea K, Masters JR, Jones GE, Wells CM
Cell Signal. 2008
PubMed ID: 18424072
Nischarin inhibits LIM kinase to regulate cofilin phosphorylation and cell invasion.
Ding Y, Milosavljevic T, Alahari SK
Mol Cell Biol. 2008
PubMed ID: 18332102
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Suppression of the invasive capacity of rat ascites hepatoma cells by knockdown of Slingshot or LIM kinase.
Horita Y, Ohashi K, Mukai M, Inoue M, Mizuno K
J Biol Chem. 2008
PubMed ID: 18171679
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Dual regulation of cofilin activity by LIM kinase and Slingshot-1L phosphatase controls platelet-derived growth factor-induced migration of human aortic smooth muscle cells.
San Martín A, Lee MY, Williams HC, Mizuno K, Lassègue B, Griendling KK
Circ Res. 2008
PubMed ID: 18096821
LIM kinase-mediated cofilin phosphorylation during mitosis is required for precise spindle positioning.
Kaji N, Muramoto A, Mizuno K
J Biol Chem. 2008
PubMed ID: 18079118
Downregulation of LIM kinase 1 suppresses ocular inflammation and fibrosis.
Gorovoy M, Koga T, Shen X, Jia Z, Yue BY, Voyno-Yasenetskaya T
Mol Vis. 2008
PubMed ID: 18978953
The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules.
Acevedo K, Li R, Soo P, Suryadinata R, Sarcevic B, Valova VA, Graham ME, Robinson PJ, Bernard O
Exp Cell Res. 2007
PubMed ID: 18028908
Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.
Wang X, Nadarajah B, Robinson AC, McColl BW, Jin JW, Dajas-Bailador F, Boot-Handford RP, Tournier C
Mol Cell Biol. 2007
PubMed ID: 17875933
Phosphorylated LIM kinases colocalize with gamma-tubulin in centrosomes during early stages of mitosis.
Chakrabarti R, Jones JL, Oelschlager DK, Tapia T, Tousson A, Grizzle WE
Cell Cycle. 2007
PubMed ID: 18000399
Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination.
Lim MK, Kawamura T, Ohsawa Y, Ohtsubo M, Asakawa S, Takayanagi A, Shimizu N
Exp Cell Res. 2007
PubMed ID: 17512523
LIM kinases: function, regulation and association with human disease.
Scott RW, Olson MF
J Mol Med. 2007
PubMed ID: 17294230
Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms.
Akagawa H, Narita A, Yamada H, Tajima A, Krischek B, Kasuya H, Hori T, Kubota M, Saeki N, Hata A, Mizutani T, Inoue I
Hum Genet. 2007
PubMed ID: 17287949
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H
Mol Cell Proteomics. 2007
PubMed ID: 17192257
Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure.
Ybot-Gonzalez P, Savery D, Gerrelli D, Signore M, Mitchell CE, Faux CH, Greene ND, Copp AJ
Development. 2007
PubMed ID: 17229766
Lim kinases, regulators of actin dynamics.
Bernard O
Int J Biochem Cell Biol. 2007
PubMed ID: 17188549
Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein.
Boateng SY, Belin RJ, Geenen DL, Margulies KB, Martin JL, Hoshijima M, de Tombe PP, Russell B
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 16963613
A role of LIM kinase 1/cofilin pathway in regulating endocytic trafficking of EGF receptor in human breast cancer cells.
Nishimura Y, Yoshioka K, Bernard O, Bereczky B, Itoh K
Histochem Cell Biol. 2006
PubMed ID: 16763828
A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases.
Pirruccello M, Sondermann H, Pelton JG, Pellicena P, Hoelz A, Chernoff J, Wemmer DE, Kuriyan J
J Mol Biol. 2006
PubMed ID: 16837009
Hsp90 increases LIM kinase activity by promoting its homo-dimerization.
Li R, Soosairajah J, Harari D, Citri A, Price J, Ng HL, Morton CJ, Parker MW, Yarden Y, Bernard O
FASEB J. 2006
PubMed ID: 16641196
LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase-type plasminogen activator system.
Bagheri-Yarmand R, Mazumdar A, Sahin AA, Kumar R
Int J Cancer. 2006
PubMed ID: 16381000
A haplotype spanning two genes, ELN and LIMK1, decreases their transcripts and confers susceptibility to intracranial aneurysms.
Akagawa H, Tajima A, Sakamoto Y, Krischek B, Yoneyama T, Kasuya H, Onda H, Hori T, Kubota M, Machida T, Saeki N, Hata A, Hashiguchi K, Kimura E, Kim CJ, Yang TK, Lee JY, Kimm K, Inoue I
Hum Mol Genet. 2006
PubMed ID: 16611674
The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors.
Wang W, Mouneimne G, Sidani M, Wyckoff J, Chen X, Makris A, Goswami S, Bresnick AR, Condeelis JS
J Cell Biol. 2006
PubMed ID: 16651380
LIM kinase 2 is widely expressed in all tissues.
Acevedo K, Moussi N, Li R, Soo P, Bernard O
J Histochem Cytochem. 2006
PubMed ID: 16399995
Different activity regulation and subcellular localization of LIMK1 and LIMK2 during cell cycle transition.
Sumi T, Hashigasako A, Matsumoto K, Nakamura T
Exp Cell Res. 2006
PubMed ID: 16455074
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration.
Kobayashi M, Nishita M, Mishima T, Ohashi K, Mizuno K
EMBO J. 2006
PubMed ID: 16456544
Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration.
Nishita M, Tomizawa C, Yamamoto M, Horita Y, Ohashi K, Mizuno K
J Cell Biol. 2005
PubMed ID: 16230460
The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones.
Tursun B, Schlüter A, Peters MA, Viehweger B, Ostendorff HP, Soosairajah J, Drung A, Bossenz M, Johnsen SA, Schweizer M, Bernard O, Bach I
Genes Dev. 2005
PubMed ID: 16204183
Single molecule recognition between cytochrome C 551 and gold-immobilized azurin by force spectroscopy.
Bonanni B, Kamruzzahan AS, Bizzarri AR, Rankl C, Gruber HJ, Hinterdorfer P, Cannistraro S
Biophys J. 2005
PubMed ID: 16192283
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
LIM kinase 1 coordinates microtubule stability and actin polymerization in human endothelial cells.
Gorovoy M, Niu J, Bernard O, Profirovic J, Minshall R, Neamu R, Voyno-Yasenetskaya T
J Biol Chem. 2005
PubMed ID: 15897190
Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.
Soosairajah J, Maiti S, Wiggan O, Sarmiere P, Moussi N, Sarcevic B, Sampath R, Bamburg JR, Bernard O
EMBO J. 2005
PubMed ID: 15660133
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Identification of markers of the midface.
Gong SG, Gong TW, Shum L
J Dent Res. 2005
PubMed ID: 15615879
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis.
Lee-Hoeflich ST, Causing CG, Podkowa M, Zhao X, Wrana JL, Attisano L
EMBO J. 2004
PubMed ID: 15538389
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase.
Meng Y, Takahashi H, Meng J, Zhang Y, Lu G, Asrar S, Nakamura T, Jia Z
Neuropharmacology. 2004
PubMed ID: 15458846
LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1.
Yang X, Yu K, Hao Y, Li DM, Stewart R, Insogna KL, Xu T
Nat Cell Biol. 2004
PubMed ID: 15220930
LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles, and process extension in primary cultured neurons.
Rosso S, Bollati F, Bisbal M, Peretti D, Sumi T, Nakamura T, Quiroga S, Ferreira A, Cáceres A
Mol Biol Cell. 2004
PubMed ID: 15090620
Caspase-mediated cleavage and activation of LIM-kinase 1 and its role in apoptotic membrane blebbing.
Tomiyoshi G, Horita Y, Nishita M, Ohashi K, Mizuno K
Genes Cells. 2004
PubMed ID: 15189451
Efficient Salmonella entry requires activity cycles of host ADF and cofilin.
Dai S, Sarmiere PD, Wiggan O, Bamburg JR, Zhou D
Cell Microbiol. 2004
PubMed ID: 15056216
Overexpression of LIM kinase 1 renders resistance to apoptosis in PC12 cells by inhibition of caspase activation.
Yang E, Kim H, Lee J, Shin JS, Yoon H, Kim SJ, Choi IH
Cell Mol Neurobiol. 2004
PubMed ID: 15176434
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
LIM kinase 1, a key regulator of actin dynamics, is widely expressed in embryonic and adult tissues.
Foletta VC, Moussi N, Sarmiere PD, Bamburg JR, Bernard O
Exp Cell Res. 2004
PubMed ID: 15023529
An unappreciated role for RNA surveillance.
Hillman RT, Green RE, Brenner SE
Genome Biol. 2004
PubMed ID: 14759258
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus.
Yokoo T, Toyoshima H, Miura M, Wang Y, Iida KT, Suzuki H, Sone H, Shimano H, Gotoda T, Nishimori S, Tanaka K, Yamada N
J Biol Chem. 2003
PubMed ID: 14530263
Williams-Beuren syndrome: a challenge for genotype-phenotype correlations.
Tassabehji M
Hum Mol Genet. 2003
PubMed ID: 12952863
LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: implications in prostate cancer.
Davila M, Frost AR, Grizzle WE, Chakrabarti R
J Biol Chem. 2003
PubMed ID: 12821664
Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1.
Foletta VC, Lim MA, Soosairajah J, Kelly AP, Stanley EG, Shannon M, He W, Das S, Massague J, Bernard O, Soosairaiah J
J Cell Biol. 2003
PubMed ID: 12963706
Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells.
Kaji N, Ohashi K, Shuin M, Niwa R, Uemura T, Mizuno K
J Biol Chem. 2003
PubMed ID: 12807904
The DNA sequence of human chromosome 7.
Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK
Nature. 2003
PubMed ID: 12853948
A role for LIM kinase in cancer invasion.
Yoshioka K, Foletta V, Bernard O, Itoh K
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12777619
Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin.
Endo M, Ohashi K, Sasaki Y, Goshima Y, Niwa R, Uemura T, Mizuno K
J Neurosci. 2003
PubMed ID: 12684437
Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta.
Birkenfeld J, Betz H, Roth D
Biochem J. 2003
PubMed ID: 12323073
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin.
Gohla A, Bokoch GM
Curr Biol. 2002
PubMed ID: 12361576
Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice.
Meng Y, Zhang Y, Tregoubov V, Janus C, Cruz L, Jackson M, Lu WY, MacDonald JF, Wang JY, Falls DL, Jia Z
Neuron. 2002
PubMed ID: 12123613
Mitosis-specific activation of LIM motif-containing protein kinase and roles of cofilin phosphorylation and dephosphorylation in mitosis.
Amano T, Kaji N, Ohashi K, Mizuno K
J Biol Chem. 2002
PubMed ID: 11925442
LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics.
Geneste O, Copeland JW, Treisman R
J Cell Biol. 2002
PubMed ID: 12034774
[LIM-kinases in actin cytoskeletal regulation and their physiological role]
Sumi T, Matsumoto K, Nakamura T
Seikagaku. 2002
PubMed ID: 12073613
Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin.
Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T
Cell. 2002
PubMed ID: 11832213
Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.
DeSilva U, Elnitski L, Idol JR, Doyle JL, Gan W, Thomas JW, Schwartz S, Dietrich NL, Beckstrom-Sternberg SM, McDowell JC, Blakesley RW, Bouffard GG, Thomas PJ, Touchman JW, Miller W, Green ED
Genome Res. 2002
PubMed ID: 11779826
Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin.
Dan C, Kelly A, Bernard O, Minden A
J Biol Chem. 2001
PubMed ID: 11413130
Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells.
Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K
J Biol Chem. 2001
PubMed ID: 11418599
Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha.
Sumi T, Matsumoto K, Shibuya A, Nakamura T
J Biol Chem. 2001
PubMed ID: 11340065
Integration of a c-myc transgene results in disruption of the mouse Gtf2ird1 gene, the homologue of the human GTF2IRD1 gene hemizygously deleted in Williams-Beuren syndrome.
Durkin ME, Keck-Waggoner CL, Popescu NC, Thorgeirsson SS
Genomics. 2001
PubMed ID: 11352562
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s).
Valero MC, de Luis O, Cruces J, Pérez Jurado LA
Genomics. 2000
PubMed ID: 11013070
Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23.
Martindale DW, Wilson MD, Wang D, Burke RD, Chen X, Duronio V, Koop BF
Mamm Genome. 2000
PubMed ID: 11003705
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop.
Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K
J Biol Chem. 2000
PubMed ID: 10652353
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.
Edwards DC, Sanders LC, Bokoch GM, Gill GN
Nat Cell Biol. 1999
PubMed ID: 10559936
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S
Science. 1999
PubMed ID: 10436159
RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.
Bach I, Rodriguez-Esteban C, Carrière C, Bhushan A, Krones A, Rose DW, Glass CK, Andersen B, Izpisúa Belmonte JC, Rosenfeld MG
Nat Genet. 1999
PubMed ID: 10431247
Signal-regulated activation of serum response factor is mediated by changes in actin dynamics.
Sotiropoulos A, Gineitis D, Copeland J, Treisman R
Cell. 1999
PubMed ID: 10428028
Comparative mapping of the region of human chromosome 7 deleted in williams syndrome.
DeSilva U, Massa H, Trask BJ, Green ED
Genome Res. 1999
PubMed ID: 10330122
Structural features of LIM kinase that control effects on the actin cytoskeleton.
Edwards DC, Gill GN
J Biol Chem. 1999
PubMed ID: 10196227
TBL2, a novel transducin family member in the WBS deletion: characterization of the complete sequence, genomic structure, transcriptional variants and the mouse ortholog.
Pérez Jurado LA, Wang YK, Francke U, Cruces J
Cytogenet Cell Genet. 1999
PubMed ID: 10575226
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition.
Wang JY, Frenzel KE, Wen D, Falls DL
J Biol Chem. 1998
PubMed ID: 9685409
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization.
Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K
Nature. 1998
PubMed ID: 9655398
A mouse single-copy gene, Gtf2i, the homolog of human GTF2I, that is duplicated in the Williams-Beuren syndrome deletion region.
Wang YK, Pérez-Jurado LA, Francke U
Genomics. 1998
PubMed ID: 9521869
The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis.
Riley P, Anson-Cartwright L, Cross JC
Nat Genet. 1998
PubMed ID: 9500551
IRS-PCR-based genetic mapping of the huntingtin interacting protein gene (HIP1) on mouse chromosome 5.
Himmelbauer H, Wedemeyer N, Haaf T, Wanker EE, Schalkwyk LC, Lehrach H
Mamm Genome. 1998
PubMed ID: 9434941
Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene (ZAN).
Gao Z, Harumi T, Garbers DL
Genomics. 1997
PubMed ID: 9126492
Regional localization of the mouse argininosuccinate lyase gene to chromosome 5.
Sutton VR, Pan Y, Craigen WJ
Mamm Genome. 1997
PubMed ID: 9337408
Self-association of LIM-kinase 1 mediated by the interaction between an N-terminal LIM domain and a C-terminal kinase domain.
Hiraoka J, Okano I, Higuchi O, Yang N, Mizuno K
FEBS Lett. 1996
PubMed ID: 8980133
Dephosphorylation of serine 3 regulates nuclear translocation of cofilin.
Nebl G, Meuer SC, Samstag Y
J Biol Chem. 1996
PubMed ID: 8824278
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients.
Osborne LR, Martindale D, Scherer SW, Shi XM, Huizenga J, Heng HH, Costa T, Pober B, Lew L, Brinkman J, Rommens J, Koop B, Tsui LC
Genomics. 1996
PubMed ID: 8812460
Structure and chromosomal localization of the genomic locus encoding the Kiz1 LIM-kinase gene.
Bernard O, Burkitt V, Webb GC, Bottema CD, Nicholl J, Sutherland GR, Matthew P
Genomics. 1996
PubMed ID: 8812497
LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition.
Frangiskakis JM, Ewart AK, Morris CA, Mervis CB, Bertrand J, Robinson BF, Klein BP, Ensing GJ, Everett LA, Green ED, Pröschel C, Gutowski NJ, Noble M, Atkinson DL, Odelberg SJ, Keating MT
Cell. 1996
PubMed ID: 8689688
LIM-kinase deleted in Williams syndrome.
Tassabehji M, Metcalfe K, Fergusson WD, Carette MJ, Dore JK, Donnai D, Read AP, Pröschel C, Gutowski NJ, Mao X, Sheer D
Nat Genet. 1996
PubMed ID: 8673124
Assignment of the human and mouse LIM-kinase genes (LIMK1; Limk1) to chromosome bands 7q11.23 and 5G1, respectively, by in situ hybridization.
Mao X, Jones TA, Williamson J, Gutowski NJ, Pröschel C, Noble M, Sheer D
Cytogenet Cell Genet. 1996
PubMed ID: 8941371
Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs.
Okano I, Hiraoka J, Otera H, Nunoue K, Ohashi K, Iwashita S, Hirai M, Mizuno K
J Biol Chem. 1995
PubMed ID: 8537403
Limk1 is predominantly expressed in neural tissues and phosphorylates serine, threonine and tyrosine residues in vitro.
Pröschel C, Blouin MJ, Gutowski NJ, Ludwig R, Noble M
Oncogene. 1995
PubMed ID: 7478547
LIMK-1 and LIMK-2, two members of a LIM motif-containing protein kinase family.
Nunoue K, Ohashi K, Okano I, Mizuno K
Oncogene. 1995
PubMed ID: 7651734
The murine LIM-kinase gene (limk) encodes a novel serine threonine kinase expressed predominantly in trophoblast giant cells and the developing nervous system.
Cheng AK, Robertson EJ
Mech Dev. 1995
PubMed ID: 8541208
Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neurons.
Bernard O, Ganiatsas S, Kannourakis G, Dringen R
Cell Growth Differ. 1994
PubMed ID: 7848918
Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif.
Mizuno K, Okano I, Ohashi K, Nunoue K, Kuma K, Miyata T, Nakamura T
Oncogene. 1994
PubMed ID: 8183554

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	Human	Mouse	Rat
Entrez Gene	3984	16885	65172
EnsEMBL Gene(s)	ENSG00000106683	ENSMUSG00000029674	ENSRNOG00000001470
Unigene	Hs.647035	Mm.15409	Rn.11250
Homologene	LIMK1	Limk1	Limk1
OMIM	601329	N/A	N/A
GeneCards	LIMK1	N/A	N/A
Beta Cell Genomics	DT.100751206 DT.101959346 DT.413487 DT.75135298 DT.97822434	DT.101131721 DT.101242293 DT.101371174 DT.101382625 DT.110673139 DT.486812 DT.91290456	N/A
Reactome	P53667	N/A	N/A
Plasma Peptide Atlas	ENSP00000336740	N/A	N/A
WikiGenes	3984	16885	65172

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Interactor	Interactor	Sources	Classification	Pubmed IDs
LIMK1	CDKN1C	HPRD, BioGRID	empirical	14530263
LIMK1	PAK4	HPRD, BioGRID	empirical	11413130
LIMK1	SEMA3A	Reactome	predicted
LIMK1	CFL1	HPRD, MINT, BioGRID	empirical	9655398 11418599 11340065 11925442 16456544 17853892 12963706 10436159
LIMK1	CFL2	HPRD	empirical	9655398 12684437 8824278
LIMK1	MAPK14	MINT	empirical	16456544
LIMK1	ABCA1	HPRD	empirical	16192283
LIMK1	NRG1	HPRD	empirical	9685409
LIMK1	HSPA4	BioGRID	empirical	17512523
LIMK1	HSP90AA1	Reactome	predicted	16641196 17188549
LIMK1	HSP90AB1	Reactome	predicted	16641196 17188549
LIMK1	LIMK1	HPRD, BioGRID	empirical	8980133 17192257
LIMK1	LIMK2	HPRD, BioGRID	empirical	8980133
LIMK1	ARRB1	IntAct	empirical	17500066
LIMK1	ARRB2	IntAct	empirical	17500066
LIMK1	MMP14	IntAct	empirical	21219645
LIMK1	PAK1	HPRD, BioGRID	empirical	10559936 10652353 11340065
LIMK1	PAK2	HPRD, IntAct	empirical	16837009
LIMK1	PARK2	BioGRID	empirical	17512523
LIMK1	RLIM	HPRD	empirical	10431247
LIMK1	PLXNA1	Reactome	predicted
LIMK1	SSH3	HPRD	empirical	15660133
LIMK1	PRKACA	MINT	empirical	19424295
LIMK1	PXN	HPRD	empirical	15023529
LIMK1	ROCK1	HPRD	empirical	10436159 10652353 11340065 10559936
LIMK1	BMPR2	HPRD, BioGRID	empirical	12963706
LIMK1	BRAF	IntAct	empirical	17979178
LIMK1	UBC	BioGRID	empirical	17512523
LIMK1	YWHAZ	HPRD, MINT, IntAct, BioGRID	empirical	12323073 12361576
LIMK1	CDC42BPA	HPRD	empirical	10652353 11340065 10559936
LIMK1	NRP1	Reactome	predicted
LIMK1	LATS1	HPRD, IntAct	empirical	15220930
LIMK1	MAPKAPK2	MINT	empirical	16456544